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Malaria surveillance

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https://www.readbyqxmd.com/read/28426116/portuguese-expatriates-health-in-angola-and-mozambique-a-cross-sectional-study-increasing-awareness-and-need-for-more-surveillance
#1
Ana Glória Fonseca, Sara S Dias, João Luis Baptista, Jorge Torgal
Background: Increasing numbers of expatriates are working in sub-Saharan Africa. There is little published data on the complex population and this survey aimed at understanding expatriate morbidity by accessing self-reported health problems and malaria preventive practices. Methods: A cross-sectional web-based survey was conducted targeting Portuguese expatriates in Angola and Mozambique. Logistic regression analysis explored factors associated with self-reported health problems and psychological symptoms in the previous 3 months...
July 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28426114/infectious-diseases-and-migrant-worker-health-in-singapore-a-receiving-country-s-perspective
#2
Sapna P Sadarangani, Poh Lian Lim, Shawn Vasoo
Background.: Approximately 1.4 million migrant workers reside in Singapore, presenting unique infectious disease challenges to both migrants and Singapore. Methods.: A Pubmed, MEDLINE (Ovid), EBSCO Host (Global Health) and Google Scholar search was performed for both peer, non-peer reviewed articles and reports relevant to migrant health in Singapore, published between 1 January 1989 and 1 September 2016. Additional studies were identified from citations within searched articles...
July 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28420422/high-resolution-melting-a-useful-field-deployable-method-to-measure-dhfr-and-dhps-drug-resistance-in-both-highly-and-lowly-endemic-plasmodium-populations
#3
Yaye Dié Ndiaye, Cyrille K Diédhiou, Amy K Bei, Baba Dieye, Aminata Mbaye, Nasserdine Papa Mze, Rachel F Daniels, Ibrahima M Ndiaye, Awa B Déme, Amy Gaye, Mouhamad Sy, Tolla Ndiaye, Aida S Badiane, Mouhamadou Ndiaye, Zul Premji, Dyann F Wirth, Souleymane Mboup, Donald Krogstad, Sarah K Volkman, Ambroise D Ahouidi, Daouda Ndiaye
BACKGROUND: Emergence and spread of drug resistance to every anti-malarial used to date, creates an urgent need for development of sensitive, specific and field-deployable molecular tools for detection and surveillance of validated drug resistance markers. Such tools would allow early detection of mutations in resistance loci. The aim of this study was to compare common population signatures and drug resistance marker frequencies between two populations with different levels of malaria endemicity and history of anti-malarial drug use: Tanzania and Sénégal...
April 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28420403/molecular-surveillance-of-plasmodium-falciparum-drug-resistance-in-the-republic-of-congo-four-and-nine-years-after-the-introduction-of-artemisinin-based-combination-therapy
#4
Felix Koukouikila-Koussounda, Sankarganesh Jeyaraj, Christian N Nguetse, Charles Nchotebah Nkonganyi, Kossiwa Clarisse Kokou, Mandingha K Etoka-Beka, Francine Ntoumi, Thirumalaisamy P Velavan
BACKGROUND: Resistance to anti-malarial drugs hinders efforts on malaria elimination and eradication. Following the global spread of chloroquine-resistant parasites, the Republic of Congo adopted artemisinin-based combination therapy (ACT) in 2006 as a first-line treatment for uncomplicated malaria. To assess the impacts after implementation of ACT, a molecular surveillance for anti-malarial drug resistance was conducted in Congo 4 and 9 years after the introduction of ACT. METHODS: Blood samples of 431 febrile children aged 1-10 years were utilized from two previous studies conducted in 2010 (N = 311) and 2015 (N = 120)...
April 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28420399/distinct-parasite-populations-infect-individuals-identified-through-passive-and-active-case-detection-in-a-region-of-declining-malaria-transmission-in-southern-zambia
#5
Kelly M Searle, Ben Katowa, Tamaki Kobayashi, Mwiche N S Siame, Sungano Mharakurwa, Giovanna Carpi, Douglas E Norris, Jennifer C Stevenson, Philip E Thuma, William J Moss
BACKGROUND: Substantial reductions in the burden of malaria have been documented in parts of sub-Saharan Africa, with elimination strategies and goals being formulated in some regions. Within this context, understanding the epidemiology of low-level malaria transmission is crucial to achieving and sustaining elimination. A 24 single-nucleotide-polymorphism Plasmodium falciparum molecular barcode was used to characterize parasite populations from infected individuals identified through passive and active case detection in an area approaching malaria elimination in southern Zambia...
April 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28420389/assessment-of-copy-number-variation-in-genes-related-to-drug-resistance-in-plasmodium-vivax-and-plasmodium-falciparum-isolates-from-the-brazilian-amazon-and-a-systematic-review-of-the-literature
#6
Gabriel Luíz Costa, Lara Cotta Amaral, Cor Jesus Fernandes Fontes, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito, Taís Nóbrega de Sousa
BACKGROUND: Parasite resistance to anti-malarials represents a great obstacle for malaria elimination. The majority of studies have investigated the association between single-nucleotide polymorphisms (SNPs) and drug resistance; however, it is becoming clear that the copy number variation (CNV) is also associated with this parasite phenotype. To provide a baseline for molecular surveillance of anti-malarial drug resistance in the Brazilian Amazon, the present study characterized the genetic profile of both markers in the most common genes associated with drug resistance in Plasmodium falciparum and Plasmodium vivax isolates...
April 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28376349/genetic-diversity-of-next-generation-antimalarial-targets-a-baseline-for-drug-resistance-surveillance-programmes
#7
Ana Rita Gomes, Matt Ravenhall, Ernest Diez Benavente, Arthur Talman, Colin Sutherland, Cally Roper, Taane G Clark, Susana Campino
Drug resistance is a recurrent problem in the fight against malaria. Genetic and epidemiological surveillance of antimalarial resistant parasite alleles is crucial to guide drug therapies and clinical management. New antimalarial compounds are currently at various stages of clinical trials and regulatory evaluation. Using ∼2000 Plasmodium falciparum genome sequences, we investigated the genetic diversity of eleven gene-targets of promising antimalarial compounds and assessed their potential efficiency across malaria endemic regions...
March 9, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28369387/resurgence-of-malaria-following-discontinuation-of-indoor-residual-spraying-of-insecticide-in-a-previously-high-transmission-intensity-area-of-uganda
#8
Saned Raouf, Arthur Mpimbaza, Ruth Kigozi, Asadu Sserwanga, Denis Rubahika, Henry Katamba, Steve W Lindsay, Bryan K Kapella, Kassahun A Belay, Moses R Kamya, Sarah G Staedke, Grant Dorsey
Background: Indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) are the primary tools for malaria prevention in Africa. It is not known whether reductions in malaria can be sustained after IRS is discontinued. The aim of this study was to assess changes in malaria morbidity in a historically high transmission area of Uganda where IRS was discontinued after a four-year period of effective control followed by a universal LLIN distribution campaign. Methods: Individual-level malaria surveillance data were collected from one outpatient department and one inpatient setting in Apac District, Uganda from July 2009 through November 2015...
March 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28369085/defining-the-next-generation-of-plasmodium-vivax-diagnostic-tests-for-control-and-elimination-target-product-profiles
#9
Xavier C Ding, Maria Paz Ade, J Kevin Baird, Qin Cheng, Jane Cunningham, Mehul Dhorda, Chris Drakeley, Ingrid Felger, Dionicia Gamboa, Matthias Harbers, Socrates Herrera, Naomi Lucchi, Alfredo Mayor, Ivo Mueller, Jetsumon Sattabongkot, Arsène Ratsimbason, Jack Richards, Marcel Tanner, Iveth J González
The global prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical attacks without involving another mosquito bite. The diagnosis of acute patent P. vivax malaria relies primarily on light microscopy...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28359340/world-malaria-report-time-to-acknowledge-plasmodium-knowlesi-malaria
#10
Bridget E Barber, Giri S Rajahram, Matthew J Grigg, Timothy William, Nicholas M Anstey
BACKGROUND: The 2016 World Health Organization (WHO) World Malaria Report documents substantial progress towards control and elimination of malaria. However, major challenges remain. In some regions of Southeast Asia, the simian parasite Plasmodium knowlesi has emerged as an important cause of human malaria, and the authors believe this species warrants regular inclusion in the World Malaria Report. MAIN TEXT: Plasmodium knowlesi is the most common cause of malaria in Malaysia, and cases have also been reported in nearly all countries of Southeast Asia...
March 31, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28358796/yellow-fever-outbreak-kongo-central-province-democratic-republic-of-the-congo-august-2016
#11
John O Otshudiema, Nestor G Ndakala, Elande-Taty K Mawanda, Gaston P Tshapenda, Jacques M Kimfuta, Loupy-Régence N Nsibu, Abdou S Gueye, Jacob Dee, Rossanne M Philen, Coralie Giese, Christopher S Murrill, Ray R Arthur, Benoit I Kebela
On April 23, 2016, the Democratic Republic of the Congo's (DRC's) Ministry of Health declared a yellow fever outbreak. As of May 24, 2016, approximately 90% of suspected yellow fever cases (n = 459) and deaths (45) were reported in a single province, Kongo Central Province, that borders Angola, where a large yellow fever outbreak had begun in December 2015. Two yellow fever mass vaccination campaigns were conducted in Kongo Central Province during May 25-June 7, 2016 and August 17-28, 2016. In June 2016, the DRC Ministry of Health requested assistance from CDC to control the outbreak...
March 31, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28355493/pfmdr1-plasmodium-falciparum-multidrug-drug-resistance-gene-1-a-pivotal-factor-in-malaria-resistance-to-artemisinin-combination-therapies
#12
J Pedro Gil, S Krishna
Plasmodium falciparum, the deadly agent of malaria, is notorious for its capacity to develop drug resistance. Treatment failures of artemisinin therapy regimens (ACTc), the present mainstay, is emerging. The transporter coding pfmdr1 gene is a central node in this process, having been associated with in vitro and in vivo parasite response to a broad range of ACT antimalarials. Areas covered: The review covers the historical origins of the pfmdr1 discovery, followed by a detailed description of its sequence and expression characteristics, as well as the structural and functional characteristics of its coded transmembrane protein...
April 10, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28327180/an-assessment-of-national-surveillance-systems-for-malaria-elimination-in-the-asia-pacific
#13
Chris Erwin G Mercado, Nattwut Ekapirat, Arjen M Dondorp, Richard J Maude
BACKGROUND: Heads of Government from Asia and the Pacific have committed to a malaria-free region by 2030. In 2015, the total number of confirmed cases reported to the World Health Organization by 22 Asia Pacific countries was 2,461,025. However, this was likely a gross underestimate due in part to incidence data not being available from the wide variety of known sources. There is a recognized need for an accurate picture of malaria over time and space to support the goal of elimination...
March 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28327145/diagnostic-challenges-and-case-management-of-the-first-imported-case-of-plasmodium-knowlesi-in-sri-lanka
#14
A Dewanee Ranaweera, Manjula N Danansuriya, Kusumawathie Pahalagedera, W M Kumudunayana T de A W Gunasekera, Priyani Dharmawardena, Keng Wai Mak, Pei-Sze Jeslyn Wong, Mei-Zhi Irene Li, Cheong Huat Tan, Hapuarachchige C Hapuarachchi, Hema D B Herath, Deepika Fernando
BACKGROUND: Sri Lanka has achieved 'malaria-free' status and is now in the phase of prevention of re-introduction of malaria. Imported malaria remains a challenge to resurgence of the disease. The diagnostic challenges encountered and the rapid response initiated to manage a Plasmodium infection, which was later confirmed as Plasmodium knowlesi, the first reported case from Sri Lanka, is discussed. CASE PRESENTATION: An army officer who returned from Malaysia in October 2016 was found to be positive for Plasmodium both by microscopy and rapid diagnostic test (RDT) by the Anti Malaria Campaign Sri Lanka (AMC) during his third visit to a health care provider...
March 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28302168/comparison-of-the-diagnostic-performance-of-microscopic-examination-with-nested-polymerase-chain-reaction-for-optimum-malaria-diagnosis-in-upper-myanmar
#15
Jung-Mi Kang, Pyo-Yun Cho, Mya Moe, Jinyoung Lee, Hojong Jun, Hyeong-Woo Lee, Seong Kyu Ahn, Tae Im Kim, Jhang Ho Pak, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim, Byoung-Kuk Na
BACKGROUND: Accurate diagnosis of Plasmodium infection is crucial for prompt malaria treatment and surveillance. Microscopic examination has been widely applied as the gold standard for malaria diagnosis in most part of malaria endemic areas, but its diagnostic value has been questioned, particularly in submicroscopic malaria. In this study, the diagnostic performance of microscopic examination and nested polymerase chain reaction (PCR) was evaluated to establish optimal malaria diagnosis method in Myanmar...
March 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28302108/confirmation-of-plasmodium-falciparum-in-vitro-resistance-to-monodesethylamodiaquine-and-chloroquine-in-dakar-senegal-in-2015
#16
Silman Diawara, Marylin Madamet, Mame Bou Kounta, Gora Lo, Khalifa Ababacar Wade, Aminata Nakoulima, Raymond Bercion, Rémy Amalvict, Mamadou Wague Gueye, Bécaye Fall, Bakary Diatta, Bruno Pradines
BACKGROUND: In response to increasing resistance to anti-malarial drugs, Senegal adopted artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria in 2006. However, resistance of Plasmodium falciparum parasites to artemisinin derivatives, characterized by delayed parasite clearance after treatment with ACT or artesunate monotherapy, has recently emerged and rapidly spread in Southeast Asia. After 10 years of stability with rates ranging from 5.6 to 11...
March 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28301474/histidine-rich-protein-2-pfhrp2-and-pfhrp3-gene-deletions-in-plasmodium-falciparum-isolates-from-select-sites-in-brazil-and-bolivia
#17
Giselle Maria Rachid Viana, Sheila Akinyi Okoth, Luciana Silva-Flannery, Danielle Regina Lima Barbosa, Alexandre Macedo de Oliveira, Ira F Goldman, Lindsay C Morton, Curtis Huber, Arletta Anez, Ricardo Luiz Dantas Machado, Luís Marcelo Aranha Camargo, Suiane Costa Negreiros do Valle, Marinete Marins Póvoa, Venkatachalam Udhayakumar, John W Barnwell
More than 80% of available malaria rapid diagnostic tests (RDTs) are based on the detection of histidine-rich protein-2 (PfHRP2) for diagnosis of Plasmodium falciparum malaria. Recent studies have shown the genes that code for this protein and its paralog, histidine-rich protein-3 (PfHRP3), are absent in parasites from the Peruvian Amazon Basin. Lack of PfHRP2 protein through deletion of the pfhrp2 gene leads to false-negative RDT results for P. falciparum. We have evaluated the extent of pfhrp2 and pfhrp3 gene deletions in a convenience sample of 198 isolates from six sites in three states across the Brazilian Amazon Basin (Acre, Rondonia and Para) and 25 isolates from two sites in Bolivia collected at different times between 2010 and 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28299154/assessment-of-malaria-reporting-and-epidemic-preparedness-systems-in-health-facilities-in-eldoret-west-district-uasin-gishu-county-kenya
#18
Ruth C Kirinyet, Arthur S Ng'etich, Ahmad Juma
The most important factor in reducing the impact of an epidemic is a timely response with implementation of effective control measures at the point of detection. This study sought to assess the malaria reporting and epidemic preparedness systems of health facilities in Eldoret West District, Kenya. A cross-sectional study design was adapted. A census technique was used to select all the forty five health facilities in the district comprising of government, mission and non-governmental facilities. An interviewer administered questionnaire was used for data collection and analysis done using Stata...
August 17, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28298235/clinical-and-molecular-surveillance-of-drug-resistant-vivax-malaria-in-myanmar-2009-2016
#19
Myat Htut Nyunt, Jin-Hee Han, Bo Wang, Khin Myo Aye, Kyin Hla Aye, Seong-Kyun Lee, Ye Htut, Myat Phone Kyaw, Kay Thwe Han, Eun-Taek Han
BACKGROUND: One of the major challenges for control and elimination of malaria is ongoing spread and emergence of drug resistance. While epidemiology and surveillance of the drug resistance in falciparum malaria is being explored globally, there are few studies on drug resistance vivax malaria. METHODS: To assess the spread of drug-resistant vivax malaria in Myanmar, a multisite, prospective, longitudinal study with retrospective analysis of previous therapeutic efficacy studies, was conducted...
March 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28290948/mortality-surveillance-for-infectious-diseases-in-the-u-s-department-of-defense-1998-2013
#20
Robert N Potter, Ladd A Tremaine, Joel C Gaydos
INTRODUCTION: The Mortality Surveillance Division (MSD) of the U.S. Armed Forces Medical Examiner System was established in 1998 to improve surveillance for all military deaths although emphasizing deaths from infectious diseases. Establishment of the MSD was part of the 1997 Department of Defense initiative to improve surveillance and response for emerging infectious diseases. Before 1998, mortality surveillance was limited to compiling information from death certificates, a system that provided limited useful information and lacked the timeliness needed to take meaningful action to address emerging infectious disease threats...
March 2017: Military Medicine
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