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Salpingectomy ovarian cancer

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https://www.readbyqxmd.com/read/29757870/changing-clinical-practice-evaluation-of-implementing-recommendations-for-opportunistic-salpingectomy-in-british-columbia-and-ontario
#1
Bryn Lander, Elizabeth Wilcox, Jessica N McAlpine, Sarah J Finlayson, David G Huntsman, Dianne Miller, Gillian E Hanley
OBJECTIVE: The aim of the study was to explore the factors that contributed to the adoption of opportunistic salpingectomies (removal of fallopian at the time of hysterectomy or in lieu of tubal ligation) by gynecologic surgeons in British Columbia (where a knowledge translation initiative took place) and in Ontario (a comparator where no knowledge translation initiative took place). We aimed to understand why the knowledge translation initiative undertaken by OVCARE in British Columbia resulted in such a dramatic uptake in opportunistic salpingectomy...
May 11, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29735278/bilateral-salpingectomy-with-delayed-oophorectomy-for-ovarian-cancer-risk-reduction-a-pilot-study-in-women-with-brca1-2-mutations
#2
Denise R Nebgen, Jean Hurteau, Laura L Holman, Andrea Bradford, Mark F Munsell, Beth R Soletsky, Charlotte C Sun, Gary B Chisholm, Karen H Lu
OBJECTIVE: Risk-reducing salpingo-oophorectomy (RRSO) reduces ovarian cancer risk in BRCA1/2 mutation carriers, but the adverse effects of the associated early-onset surgical menopause are problematic. Despite suggestive evidence, no data demonstrate whether bilateral salpingectomy alone lowers the risk of developing ovarian cancer in BRCA mutation carriers. We conducted a pilot study of bilateral salpingectomy with delayed oophorectomy (BS/DO) in BRCA mutation carriers to determine the safety and acceptability of the procedure...
May 4, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29704813/opportunistic-prophylactic-salpingectomy-for-prevention-of-ovarian-cancer-what-do-national-societies-advise
#3
Angelika Ntoumanoglou-Schuiki, Gordana Tomasch, Rene Laky, Nadja Taumberger, Vesna Bjelic-Radisic, Karl Tamussino
OBJECTIVE: To determine how many FIGO (International Federation of Obstetrics and Gynecology) member societies have statements regarding opportunistic (incidental, prophylactic, risk-reducing) salpingectomy at the time of benign gynecologic surgery and to categorize statements as positive, negative or ambivalent. STUDY DESIGN: The websites of the 130 FIGO member societies were searched for statements on opportunistic salpingectomy. We looked for separate statements and statements embedded in other documents such as clinical guidelines as well as statements by national societies of gynecologic oncology...
March 30, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29676714/-does-ovarian-cancer-start-in-the-fallopian-tubes-possible-implications-for-preventive-adnexal-removal
#4
M P Steenbeek, J Bulten, N Hoogerbrugge, L F A G Massuger, J M A Pijnenborg, J A de Hullu
BACKGROUND: Recent insights in high-grade serous ovarian cancer development are pointing to the fallopian tubes as likely place of origin and not the ovaries themselves. This may have consequences for patients with increased risk of ovarian cancer. Adnexal removal is currently recommended for this patient group at an age of 35-45, which leads to premature menopause. CASE DESCRIPTION: In a 55-year-old woman with a BRCA1 germ line mutation, a high-grade serous carcinoma was unexpectedly diagnosed in both fallopian tubes during preventive adnexal removal...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29656331/survey-of-pelvic-reconstructive-surgeons-on-performance-of-opportunistic-salpingectomy-at-the-time-of-pelvic-organ-prolapse-repair
#5
Daisy B Hassani, Jeffrey M Mangel, Sangeeta T Mahajan, Adonis K Hijaz, Sherif El-Nashar, David Sheyn
INTRODUCTION AND HYPOTHESIS: Opportunistic salpingectomy (OS) at the time of benign hysterectomy has recently emerged as a potential primary preventive modality for ovarian cancer. Our objective was to determine whether the reported rate of OS at the time of prolapse surgery is similar to the rate of OS at the time of gynecologic surgery for non-prolapse indications. METHODS: An anonymous online survey was sent to the Society of Gynecologic Surgery members. Responses were divided into surgeons who did and did not perform OS at the time of prolapse repair...
April 14, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29630008/ovarian-cancer-prevention-and-screening
#6
Usha Menon, Chloe Karpinskyj, Aleksandra Gentry-Maharaj
There has been much progress in ovarian cancer screening and prevention in recent years. Improved tools that combine genetic and epidemiologic factors to predict an individual's ovarian cancer risk are set to become available for tailoring preventive and screening approaches. The increasing evidence on tubal origins of a proportion of ovarian cancer has paved the way to use of opportunistic bilateral salpingectomy at tubal ligation and hysterectomy in the general population. Clinical trials are in progress to estimate the long-term effects on endocrine function...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29600234/prophylactic-salpingectomy-and-ovarian-cancer-an-evidence-based-analysis
#7
Tricia Dewi Anggraeni, Adly Nanda Al Fattah, Raymond Surya
Introduction: One of the ovarian carcinogenesis theories was the presence of premalignant cells in the epithelium of the fallopian tube. Therefore, the prophylactic salpingectomy during benign gynecological surgery is now expected as the attempt to reduce the ovarian cancer incidence. We studied the effect of prophylactic bilateral salpingectomy (PBS) in reducing the ovarian cancer incidence. Methods: This evidence-based report resulted from critical appraisal of 5 articles...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29505655/risk-reducing-salpingectomy-versus-standard-tubal-sterilization-lessons-from-offering-women-options-for-interval-sterilization
#8
Matthew L Zerden, Tara Castellano, Kemi M Doll, Gretchen S Stuart, M Cris Munoz, Kim A Boggess
OBJECTIVES: In women receiving sterilization, the removal of the entire fallopian tube, a procedure referred to as a risk-reducing salpingectomy (RRS), reduces subsequent ovarian cancer risk compared with standard tubal sterilization procedures. There are limited data on which surgical procedure women will choose when educated about the benefits of an RRS. Our objective was to study the proportion of women desiring sterilization that would choose an RRS. METHODS: This cohort study included women 30 years of age and older with a living biological child who requested laparoscopic sterilization at a tertiary academic hospital...
March 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29425721/using-a-mobile-smartphone-to-perform-laparoscopy
#9
Ioannis Chatzipapas, Nikolaos Kathopoulis, Athanasios Protopapas, Dimitrios Loutradis
Laparoscopy has gradually expanded its use in gynecologic surgery over the last 3 decades. In this report, a new laparoscopic setup is presented using a mobile smartphone that allows for a low-cost, portable laparoscopic viewing system. The setup was created with the coupling of a rigid 0-degree, 10-mm-diameter laparoscope via a commercially available adapter with a smartphone. The light source used was also a portable and rechargeable light-emitting diode cold light source. We completed 17 diagnostic laparoscopies for different pathologies such as ectopic pregnancy, ovarian torsion, a luteal hemorrhagic cyst, and disseminated ovarian cancer...
February 6, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29317075/the-origin-of-endometriosis-associated-ovarian-cancer-from-uterine-neoplastic-lesions
#10
Elisabetta Garavaglia, Cristina Sigismondi, Stefano Ferrari, Massimo Candiani
Endometriosis is a risk factor for type I epithelial ovarian cancer but an issue to be clarified is the site of origin of endometriosis associated ovarian cancer. Here we proposed that the uterus may be the organ of origin of ovarian endometrioid cancer associated with endometriosis. Thus, the first neoplastic transformation would characterize the uterine cells migrating in the pelvis via retrograde menstruation and they would implant secondarily on the ovary. Supporting this hypothesis, an higher incidence of synchronous precancerous and cancerous endometrial pathology in patients affected by ovarian endometrioid cancer associated with endometriosis was showed...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29315498/peritoneal-carcinomatosis-after-risk-reducing-surgery-in-brca1-2-mutation-carriers
#11
Marline G Harmsen, Jurgen M J Piek, Johan Bulten, Murray J Casey, Timothy R Rebbeck, Marian J Mourits, Mark H Greene, Brigitte F M Slangen, Marc van Beurden, Leon F A G Massuger, Nicoline Hoogerbrugge, Joanne A de Hullu
BACKGROUND: Risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA1/2 mutation carriers because of their increased risk of ovarian carcinoma. Despite RRSO, metachronous peritoneal carcinomatosis occasionally is diagnosed. METHODS: The literature was searched for BRCA1/2 mutation carriers with peritoneal carcinomatosis after risk-reducing surgery. The authors were asked for additional data. Clinical and histopathological data were descriptively analyzed...
March 1, 2018: Cancer
https://www.readbyqxmd.com/read/29298171/expression-of-%C3%AE-v-tubulin-in-secretory-cells-of-the-fallopian-tube-epithelium-marks-cellular-atypia
#12
Deepti Mathew, Yanhua Wang, Anne Van Arsdale, Susan Band Horwitz, Hayley McDaid
OBJECTIVES: Class V Beta tubulin isotype (βV-tubulin) was recently found to have tissue-specific expression patterns in epithelial tissues with secretory function and aberrant expression in tumors. The aims of this pilot study were (a) to examine expression of βV-tubulin in the fallopian tube epithelium (FTE) of patients who underwent salpingectomy, (b) to characterize FTE atypia in high-risk patients with BRCA mutations, and (c) to determine expression of βV-tubulin in serous ovarian neoplasms...
February 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29290779/opportunistic-salpingectomy-at-benign-gynecological-surgery-for-reducing-ovarian-cancer-risk-a-10-year-single-centre-experience-from-china-and-a-literature-review
#13
Ying Chen, Hui Du, Lewen Bao, Wenxin Liu
Current evidences indicate that the fallopian tube plays a major role in the pathogenesis of epithelial ovarian cancer (EOC). Salpingectomy represents a novel and potentially effective risk-reducing option. In this study, there were 1822 patients diagnosed and treated for EOC or primary peritoneal cancer (PPC) at Department of Gynecologic Oncology, Tianjin Medical University Cancer Institute and Hospital from January 1, 2007 to April 30, 2017. Among them, 198 patients with a history of gynecological surgery because of benign diseases were enrolled to analyze further...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29278600/ovarian-cancer-prevention-screening-and-early-detection-report-from-the-11th-biennial-ovarian-cancer-research-symposium
#14
Jeremy Chien, Elizabeth M Poole
OBJECTIVE: The aim of this study is to provide a summary report on recent research advances in ovarian cancer prevention, screening, and early detection that were presented at the 11th Biennial Ovarian Cancer Research Symposium in Seattle, Wash. METHODS: At the symposium, researchers from around the world participated in the poster, invited oral presentation and keynote presentation, and discussed the latest advances in the areas of cancer prevention, screening, and early detection...
November 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29273351/to-oophorectomy-or-not-to-oophorectomy-practice-patterns-among-urologists-treating-bladder-cancer
#15
Rachael D Sussman, Chihun J Han, Daniel Marchalik, Filipe L Carvahlo, Meghan F Davis, Lee A Richter, Stephanie L Wethington, Lambros Stamatakis
OBJECTIVES: Classically, radical cystectomy (RC) involves hysterectomy and bilateral salpingo-oophorectomy (BSO). Current understanding of ovarian cancer pathogenesis and effect of premature oophorectomy has lead to a shift within gynecology toward risk-reducing salpingectomy without oophorectomy in the absence of gynecologic malignancy. The purpose of this study was to assess knowledge base and practice patterns of urologic oncologists with regard to management of the gynecological organs at the time of RC...
March 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29164264/risks-and-benefits-of-salpingectomy-at-the-time-of-sterilization
#16
Tara Castellano, Matthew Zerden, Laura Marsh, Kim Boggess
Importance: Bilateral salpingectomy reduces the risk ovarian cancer. The Society of Gynecologic Oncology has recommended surgeons discuss salpingectomy with patients desiring sterilization. Objective: This review summarizes current literature on the benefits and risks of bilateral salpingectomy to reduce ovarian cancer risk. Areas of insufficient evidence and directions for further research are discussed. Evidence Acquisition: We examined the benefits and risks of bilateral salpingectomy for female surgical sterilization, using a PubMed and EMBASE literature review...
November 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29133151/laparoscopic-management-of-a-rudimentary-uterine-horn
#17
Emilie Faller, Jean Jacques Baldauf, François Becmeur, Anne Lehn, Cherif Youssef Akladios, Lise Lecointre
STUDY OBJECTIVE: To demonstrate a technique of laparoscopic management of a rudimentary horn in a 12-year-old girl. DESIGN: A step-by-step explanation of the surgery using a video (instructive video) approved by the local institutional review board. SETTING: A university hospital (University Hospital of Strasbourg, Strasbourg, France). PATIENT: A 12-year-old girl with a uterine rudimentary horn. INTERVENTION: We describe a case of a 12-year-old girl who had no medical history...
November 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29097232/cancer-risk-reducing-opportunities-in-gynecologic-surgery
#18
REVIEW
Carolyn Piszczek, Jun Ma, Claire H Gould, Paul Tseng
This review article discusses cancer risk-reducing opportunities in gynecologic surgery. We cover strategies to reduce ovarian and uterine cancer risk by presenting general practice guidelines and expanding on the literature behind clinical decision points. We address populations of women at increased hereditary risk and those at population risk. We specifically discuss risk-reducing salpingo-oophorectomy, prophylactic salpingectomy with delayed oophorectomy, concomitant hysterectomy, opportunistic salpingectomy, bilateral tubal ligation, and hysterectomy...
October 31, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29054509/the-cost-effectiveness-of-salpingectomies-for-family-planning-in-the-prevention-of-ovarian-cancer
#19
R W Melissa Tai, Stephanie K Y Choi, Peter C Coyte
OBJECTIVE: Ovarian cancer is the most lethal gynaecologic cancer. Disease prevention may be the only method to reduce the incidence of ovarian cancer. The Society of Gynecologic Oncology advised that salpingectomies may be an appropriate and feasible strategy for ovarian cancer risk reduction. This study conducted an economic evaluation from a societal perspective of bilateral salpingectomies versus conventional sterilization techniques in the prevention of ovarian cancer. STUDY DESIGN: We performed a micro-cost analysis comparing laparoscopic tubal coagulation, tubal clips and bilateral salpingectomies at the Michael Garron Hospital, formerly the Toronto East General Hospital, from 2015 to 2016...
March 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28957952/risk-reducing-surgery-in-women-at-low-lifetime-risk-of-developing-ovarian-carcinoma-opportunistic-salpingectomy
#20
Gillian E Hanley, Nirit M K Rozenberg, Jessica N McAlpine
Lack of success in ovarian cancer control through screening or advances in treatment in the general population has prompted exploration in new avenues of prevention. "Opportunistic" salpingectomy describes a surgical procedure or risk-reducing intent in women at low-risk/general population risk for developing ovarian cancer who are undergoing pelvic/abdominal surgery for other indications. This chapter reviews the uptake, safety, and anticipated impact of this prevention initiative.
December 2017: Clinical Obstetrics and Gynecology
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