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https://www.readbyqxmd.com/read/28336173/effects-of-artesunate-on-some-biochemical-parameters-in-pregnant-albino-wistar-rats-challenged-with-lethal-strain-plasmodium-berghei-nk65-appreciating-the-activities-of-artemisinin-drugs-on-key-pregnancy-hormone-balance
#1
Chinaka O Nwaehujor, Onyeka V Asuzu, Daniel D Nwibo, Obichukwu C Nwobi, Ihechiluru I Ezeigbo
In humans, malaria in pregnancy can cause serious maternal and foetal morbidity and in extreme untreated cases, foetal mortality occurs. The therapeutic approach to curbing this malaise is the administration of an effective and/or combinations of anti-malaria medicaments. Acute or chronic administration of some of these drugs, however, gives rise to some adverse medical conditions including reproductive dysfunction, especially in pregnancy. Studies aimed at the hormonal interplays following administration of these drugs in pregnancy have been limited due to too few appropriate animal models...
March 20, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28303431/gender-inequalities-in-remote-settings-analysis-of-105-025-medical-records-of-a-rural-hospital-in-ethiopia-2005-2015
#2
Sandro Accorsi, Edgardo Somigliana, Pasquale Farese, Tsegaye Ademe, Yonas Desta, Giovanni Putoto, Fabio Manenti
Gender inequalities in Sub-Saharan Africa are deemed relevant but data to support this view are scanty. Retrospective analysis of a large dataset of 105,025 patients admitted to an Ethiopian rural private, non-for-profit hospital over a 11 years period (2005-2015). Since 2001, the hospital and the local community are involved in a long-term, comprehensive and externally-supported health care intervention. The total number of admissions was higher for females (61.9% of the total) mainly because of the high frequency of admissions for obstetrics conditions...
March 16, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28274003/comparative-study-on-antenatal-and-perinatal-outcome-of-vivax-and-falciparum-malaria-in-a-tertiary-care-hospital-of-kolkata-india
#3
Mousumi Datta, Jhuma Biswas, Shyamal Dasgupta, Kaushik Banerjee, Subhendu Choudhury, Sandip Kumar Sengupta, Prakash Das
INTRODUCTION: Malaria occurring in pregnancy is associated with considerable maternal and perinatal morbidity. In India, the problem is compounded by dual parasitological aetiology of Plasmodiumvivax (P.vivax) and Plasmodium falciparum (P.falciparum). AIM: To compare the outcome of infections by P. vivax and P.falciparum species among pregnant women in a hospital setting. MATERIALS AND METHODS: Pregnant women who tested positive for malaria either by microscopy of peripheral blood smear or ELISA test for double antigen were enrolled in the study...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28272734/safety-and-benefits-of-antenatal-oral-iron-supplementation-in-low-income-countries-a-review
#4
REVIEW
Martin N Mwangi, Andrew M Prentice, Hans Verhoef
The World Health Organization recommends universal iron supplementation of 30-60 mg/day in pregnancy but coverage is low in most countries. Its efficacy is uncertain, however, and there has been a vigorous debate in the last decade about its safety, particularly in areas with a high burden of malaria and other infectious diseases. We reviewed the evidence on the safety and efficacy of antenatal iron supplementation in low-income countries. We found no evidence that daily supplementation at a dose of 60 mg leads to increased maternal Plasmodium infection risk...
March 8, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28261219/naturally-acquired-binding-inhibitory-antibodies-to-plasmodium-vivax-duffy-binding-protein-in-pregnant-women-are-associated-with-higher-birth-weight-in-a-multicenter-study
#5
Pilar Requena, Myriam Arévalo-Herrera, Michela Menegon, Flor E Martínez-Espinosa, Norma Padilla, Camila Bôtto-Menezes, Adriana Malheiro, Dhiraj Hans, Maria Eugenia Castellanos, Leanne Robinson, Paula Samol, Swati Kochar, Sanjay K Kochar, Dhanpat K Kochar, Meghna Desai, Sergi Sanz, Llorenç Quintó, Alfredo Mayor, Stephen Rogerson, Ivo Mueller, Carlo Severini, Hernando A Del Portillo, Azucena Bardají, Chetan C Chitnis, Clara Menéndez, Carlota Dobaño
A vaccine to eliminate malaria would need a multi-stage and multi-species composition to achieve robust protection, but the lack of knowledge about antigen targets and mechanisms of protection precludes the development of fully efficacious malaria vaccines, especially for Plasmodium vivax (Pv). Pregnant women constitute a risk population who would greatly benefit from a vaccine preventing the adverse events of Plasmodium infection during gestation. We hypothesized that functional immune responses against putative targets of naturally acquired immunity to malaria and vaccine candidates will be associated with protection against malaria infection and/or poor outcomes during pregnancy...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28256926/-when-i-am-with-my-husband-i-do-not-feel-mosquito-bite
#6
Mary Anita Quist, Augustine Adomah-Afari
Purpose The purpose of this paper is to explore how socio-cultural beliefs and practices could influence the knowledge, attitude and perception of insecticide-treated net (ITN) use in the control of malaria amongst pregnant women attending antenatal clinic. Design/methodology/approach Data were gathered using interviews and documentary review. Framework analysis was applied to classify emerging themes and the findings interpreted using the health belief model. Findings The findings showed that the pregnant women had appreciable knowledge, both the positive and negative attitudes and the perceptions of insecticide treated nets...
March 13, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28251544/-malaria-and-intestinal-parasitosis-in-pregnant-woman-at-abobo-district-abidjan-c%C3%A3-te-d-ivoire
#7
G Coulibaly, K P Yao, M Koffi, B A Ahouty, L K Louhourignon, M N'Cho, E K N'Goran
A prospective study was carried out from 2010 to 2012 at the Hôpital Général d'Abobo (HGA) in Abidjan, in order to determine the impact of infectious and parasitic diseases on child cognitive development. Blood samples were examined by means of thick drop and blood smear; as for stool by direct examination and concentration by formalin-ether method. We evaluated the prevalence, the parasite load of malaria and gastrointestinal parasites; then we investigated the risk factors for these disorders. Overall, 331 pregnant women in the last trimester of their pregnancy were enrolled...
March 1, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28245259/estimated-impact-on-birth-weight-of-scaling-up-intermittent-preventive-treatment-of-malaria-in-pregnancy-given-sulphadoxine-pyrimethamine-resistance-in-africa-a-mathematical-model
#8
Patrick G T Walker, Jessica Floyd, Feiko Ter Kuile, Matt Cairns
BACKGROUND: Malaria transmission has declined substantially in the 21st century, but pregnant women in areas of sustained transmission still require protection to prevent the adverse pregnancy and birth outcomes associated with malaria in pregnancy (MiP). A recent call to action has been issued to address the continuing low coverage of intermittent preventive treatment of malaria in pregnancy (IPTp). This call has, however, been questioned by some, in part due to concerns about resistance to sulphadoxine-pyrimethamine (SP), the only drug currently recommended for IPTp...
February 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28241832/the-malaria-testing-and-treatment-market-in-kinshasa-democratic-republic-of-the-congo-2013
#9
Godéfroid Mpanya, Antoinette Tshefu, Joris Losimba Likwela
BACKGROUND: The Democratic Republic of Congo (DRC) is one of the two most leading contributors to the global burden of disease due to malaria. This paper describes the malaria testing and treatment market in the nation's capital province of Kinshasa, including availability of malaria testing and treatment and relative anti-malarial market share for the public and private sector. METHODS: A malaria medicine outlet survey was conducted in Kinshasa province in 2013...
February 28, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28238206/synergistic-effect-of-ddt-and-its-metabolites-in-lipopolysaccharide-mediated-tnf-%C3%AE-production-is-inhibited-by-progesterone-in-peripheral-blood-mononuclear-cells
#10
Pablo Dominguez-Lopez, Laura Diaz-Cueto, Arturo Aguilar-Rojas, Fabian Arechavaleta-Velasco
Increased TNF-α levels have been associated with adverse pregnancy outcomes. Lipopolysaccharide (LPS), 1,1,1-trichloro-2,2-bis-(chlorophenyl)ethane (DDT), 1,1-bis-(chlorophenyl)-2,2-dichloroethene (DDE), and 1,1-dichloro-2,2-bis(chlorophenyl)ethane (DDD) induce TNF-α release in peripheral blood mononuclear cells (PBMC). Conversely, progesterone (P4) inhibits TNF-α secretion. Pregnant women in malaria endemic areas may be co-exposure to these compounds. Thus, this study was to investigate the synergistic effect of LPS and these pesticides in PBMC and to assess P4 influence on this synergy...
February 26, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28237831/different-origin-and-dispersal-of-sulphadoxine-resistant-plasmodium-falciparum-haplotypes-between-eastern-africa-and-democratic-republic-of-congo
#11
Vito Baraka, Christopher Delgado-Ratto, Sidsel Nag, Deus S Ishengoma, Rashid A Madebe, Hypolite Muhindo Mavoko, Carolyn Nabasumba, Pascal Lutumba, Michael Alifrangis, Jean-Pierre Van Geertruyden
Sulphadoxine/pyrimethamine (SP) is still used for malaria control in sub-Saharan Africa; however, widespread resistance is a major concern. This study aimed to determine the dispersal and origin of sulphadoxine resistance lineages in the Democratic Republic of the Congo compared with East African Plasmodium falciparum dihydropteroate synthetase (Pfdhps) haplotypes. The analysis involved 264 isolates collected from patients with uncomplicated malaria from Tanzania, Uganda and DR Congo. Isolates were genotyped for Pfdhps mutations at codons 436, 437, 540, 581 and 613...
February 22, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28236734/midwives-provision-of-antimalaria-services-to-pregnant-women-in-uganda
#12
Richard Serunkuma Bbosa, Valerie Janet Ehlers
OBJECTIVES: malaria causes complications during 80% of all pregnancies in Uganda. However, only 48% of Ugandan pregnant women took one dose of intermittent preventive therapy while merely 27% took the second dose during 2011. This study investigated midwives' provision of anti-malaria services in the Buikwe District of Uganda. DESIGN: a quantitative exploratory descriptive design was used. SETTING: prenatal clinics (n=16) in the Buikwe District of Uganda RESPONDENTS: questionnaires were completed by 40 (out of a population of 45) midwives...
February 20, 2017: Midwifery
https://www.readbyqxmd.com/read/28219435/changing-the-policy-for-intermittent-preventive-treatment-with-sulfadoxine-pyrimethamine-during-pregnancy-in-malawi
#13
Chikondi A Mwendera, Christiaan de Jager, Herbert Longwe, Kamija Phiri, Charles Hongoro, Clifford M Mutero
BACKGROUND: The growing resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) treatment for uncomplicated malaria led to a recommendation by the World Health Organization for the use of artemisinin-based combination therapy. Inevitably, concerns were also raised surrounding the use of SP for intermittent prevention treatment of malaria during pregnancy (IPTp) amidst the lack of alternative drugs. Malawi was the first country to adopt intermittent prevention treatment with SP in 1993, and updated in 2013...
February 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28213434/malaria-during-pregnancy
#14
Michal Fried, Patrick E Duffy
One hundred and twenty-five million women in malaria-endemic areas become pregnant each year (see Dellicour et al. PLoS Med7: e1000221 [2010]) and require protection from infection to avoid disease and death for themselves and their offspring. Chloroquine prophylaxis was once a safe approach to prevention but has been abandoned because of drug-resistant parasites, and intermittent presumptive treatment with sulfadoxine-pyrimethamine, which is currently used to protect pregnant women throughout Africa, is rapidly losing its benefits for the same reason...
February 17, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28187497/antiretroviral-therapy-with-efavirenz-accentuates-pregnancy-associated-reduction-of-dihydroartemisinin-piperaquine-exposure-during-malaria-chemoprevention
#15
Richard Kajubi, Liusheng Huang, Prasanna Jagannathan, Nona Chamankhah, Moses Were, Theodore Ruel, Catherine A Koss, Abel Kakuru, Norah Mwebaza, Moses Kamya, Diane Havlir, Grant Dorsey, Philip J Rosenthal, Francesca T Aweeka
Dihydroartemisinin (DHA)-piperaquine is promising for malaria chemoprevention in pregnancy. We assessed impacts of pregnancy and efavirenz-based antiretroviral therapy on exposure to DHA and piperaquine in pregnant Ugandan women. Intensive sampling was performed at 28 weeks gestation in 31 HIV-uninfected pregnant women, in 27 HIV-infected pregnant women receiving efavirenz, and in 30 HIV-uninfected non-pregnant women. DHA peak concentration and area under the concentration time curve (AUC0-8hr ) were 50% and 47% lower, respectively, and piperaquine AUC0-21d was 40% lower in pregnant women compared to non-pregnant women...
February 10, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28178298/the-impact-of-prenatal-exposure-to-parasitic-infections-and-to-anthelminthic-treatment-on-antibody-responses-to-routine-immunisations-given-in-infancy-secondary-analysis-of-a-randomised-controlled-trial
#16
Stephen Nash, Alexander J Mentzer, Swaib A Lule, Dennison Kizito, Gaby Smits, Fiona R M van der Klis, Alison M Elliott
BACKGROUND: Chronic parasitic infections are associated with active immunomodulation which may include by-stander effects on unrelated antigens. It has been suggested that pre-natal exposure to parasitic infections in the mother impacts immunological development in the fetus and hence the offspring's response to vaccines, and that control of parasitic infection among pregnant women will therefore be beneficial. METHODOLOGY/PRINCIPAL FINDINGS: We used new data from the Entebbe Mother and Baby Study, a trial of anthelminthic treatment during pregnancy conducted in Uganda, to further investigate this hypothesis...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28168042/coinfection-with-schistosoma-haematobium-and-plasmodium-falciparum-and-anaemia-severity-among-pregnant-women-in-munyenge-mount-cameroon-area-a-cross-sectional-study
#17
Judith K Anchang-Kimbi, Dillys Mansoh Elad, Gemain Taiwe Sotoing, Eric Akum Achidi
Background. Malaria and urogenital schistosomiasis are coendemic in Mount Cameroon Area. This study investigated the prevalence of S. haematobium, P. falciparum, and coinfections and their effect on anaemia in pregnancy. Methods. Pregnant women reporting for antenatal care (ANC) clinic visit in Munyenge were enrolled. S. haematobium and P. falciparum infections were determined by urine filtration and microscopy, respectively. Haemoglobin (Hb) levels were measured using haemoglobinometer. Of 250 women, 46.8%, 39...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/28166246/soluble-human-leukocyte-antigen-g-during-pregnancy-and-infancy-in-benin-mother-child-resemblance-and-association-with-the-risk-of-malaria-infection-and-low-birth-weight
#18
Tania C d'Almeida, Ibrahim Sadissou, Jacqueline Milet, Gilles Cottrell, Amandine Mondière, Euripide Avokpaho, Laure Gineau, Audrey Sabbagh, Achille Massougbodji, Kabirou Moutairou, Eduardo A Donadi, Benoit Favier, Edgardo Carosella, Philippe Moreau, Nathalie Rouas-Freiss, David Courtin, André Garcia
Human leukocyte antigen (HLA) G is a tolerogenic molecule involved in the maternal-fetal immune tolerance phenomenon. Its expression during some infectious diseases leading to immune evasion has been established. A first study conducted in Benin has shown that the production of soluble HLA-G (sHLA-G) during the first months of life is strongly correlated with the maternal level at delivery and associated with low birth weight and malaria. However sHLA-G measurements during pregnancy were not available for mothers and furthermore, to date the evolution of sHLA-G in pregnancy is not documented in African populations...
2017: PloS One
https://www.readbyqxmd.com/read/28148260/individuals-living-in-a-malaria-endemic-area-of-cameroon-do-not-have-an-acquired-antibody-response-to-plasmodium-falciparum-histidine-rich-protein-2
#19
Diane Wallace Taylor, Naveen Bobbili, Vedbar S Khadka, Isabella A Quakyi, Rose G F Leke
BACKGROUND: Diagnosis of Plasmodium falciparum is often based on detection of histidine-rich protein 2 (HRP2) in blood. Most HRP2-based assays have high sensitivity and specificity; however, authors have suggested that antibodies (Ab) to HRP2 could reduce assay sensitivity. This study sought to characterize the antibody response to HRP2 with respect to prevalence, class, subclass, affinity, and age distribution in Cameroonian children and adults residing in an area with high P. falciparum transmission...
February 1, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28115667/vitamin-a-and-zinc-supplementation-among-pregnant-women-to-prevent-placental-malaria-a-randomized-double-blind-placebo-controlled-trial-in-tanzania
#20
Anne Marie Darling, Ferdinand M Mugusi, Analee J Etheredge, Nilupa S Gunaratna, Ajibola Ibraheem Abioye, Said Aboud, Christopher Duggan, Robert Mongi, Donna Spiegelman, Drucilla Roberts, Davidson H Hamer, Kevin C Kain, Wafaie W Fawzi
Vitamin A and zinc are important for immune function and may improve host defense against malaria and reduce the risk of adverse pregnancy outcomes. Our objective was to determine whether daily oral supplementation with either or both nutrients starting in the first trimester reduces the risk of placental malaria and adverse pregnancy outcomes. We undertook a randomized, double-blind placebo-controlled trial with a factorial design among 2,500 human immunodeficiency virus-negative primigravid or secundigravid pregnant women in their first trimester of pregnancy in Dar es Salaam, Tanzania...
January 23, 2017: American Journal of Tropical Medicine and Hygiene
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