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Malaria pregnancy

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https://www.readbyqxmd.com/read/29346002/intermittent-preventive-therapy-in-pregnancy-and-incidence-of-low-birth-weight-in-malaria-endemic-countries
#1
Jordan E Cates, Daniel Westreich, Holger W Unger, Melissa Bauserman, Linda Adair, Stephen R Cole, Steven Meshnick, Stephen J Rogerson
OBJECTIVES: To estimate the impact of hypothetical antimalarial and nutritional interventions (which reduce the prevalence of low midupper arm circumference [MUAC]) on the incidence of low birth weight (LBW). METHODS: We analyzed data from 14 633 pregnancies from 13 studies conducted across Africa and the Western Pacific from 1996 to 2015. We calculated population intervention effects for increasing intermittent preventive therapy in pregnancy (IPTp), full coverage with bed nets, reduction in malaria infection at delivery, and reductions in the prevalence of low MUAC...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29342401/matched-placental-and-circulating-plasmodium-falciparum-parasites-are-genetically-homologous-at-the-var2csa-id1-dbl2x-locus-by-deep-sequencing
#2
Andreea Waltmann, Jaymin C Patel, Kyaw L Thwai, Nicholas J Hathaway, Christian M Parobek, Achille Massougbodji, Nadine Fievet, Jeffery A Bailey, Philippe Deloron, Jonathan J Juliano, Nicaise Tuikue Ndam, Steven R Meshnick
In pregnancy-associated malaria, infected erythrocytes accumulate in the placenta. It is unclear if in polyclonal infections this results in distinct peripheral and placental parasite populations. We used long amplicon deep sequencing of Plasmodium falciparum var2csa ID1-DBL2X from 15 matched peripheral and placental samples collected at delivery from a high transmission area to determine genetic homology. Despite substantial sequence variation and detecting 23 haplotypes, the matched pairs mostly contained the same genetic variants, with 11 pairs sharing 100% of their variants, whereas others showed some heterogeneity...
January 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29332155/prevalence-of-the-pfdhfr-and-pfdhps-mutations-among-asymptomatic-pregnant-women-in-southeast-nigeria
#3
Ekpereonne Esu, Costanza Tacoli, Prabhanjan Gai, Nicole Berens-Riha, Michael Pritsch, Thomas Loescher, Martin Meremikwu
Sulfadoxine-pyrimethamine (SP) is the recommended drug for intermittent preventive treatment of malaria in pregnancy in most of sub-Saharan Africa. Resistance to SP is related to mutations in the dhfr and dhps gene of Plasmodium falciparum. This study determined the prevalence of Pfdhfr and Pfdhps polymorphisms found in asymptomatic pregnant women attending antenatal care in Calabar, Nigeria. From October 2013 to November 2014, asymptomatic pregnant women attending antenatal care clinics were enrolled after obtaining informed consent...
January 13, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29325055/prevalence-and-associated-risk-factors-of-malaria-in-the-first-trimester-of-pregnancy-a-pre-conceptional-cohort-study-in-benin
#4
Manfred Accrombessi, Nadine Fievet, Emmanuel Yovo, Gilles Cottrell, Gino Agbota, Achille Massougbodji, Michel Cot, Valérie Briand
Background: There is a lack of data on the burden of malaria in first trimester of pregnancy in Africa mainly because pregnant women generally attend the maternity clinic late. Therefore, bed nets are rarely provided to women before the 2nd trimester of pregnancy. Besides, intermittent preventive treatment with sulfadoxine-pyrimethamine is not recommended before the 2nd trimester, leaving women insufficiently or not protected in early pregnancy. Methods: To assess the burden of malaria in the first trimester, 387 women were followed-up monthly from pre-conception to delivery...
January 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29317740/increased-susceptibility-to-plasmodium-falciparum-in-infants-is-associated-with-low-not-high-placental-malaria-parasitemia
#5
Samuel Tassi Yunga, Genevieve G Fouda, Grace Sama, Julia B Ngu, Rose G F Leke, Diane W Taylor
Risk of malaria in infants can be influenced by prenatal factors. In this study, the potential for placental parasitemia at delivery in predicting susceptibility of infants to Plasmodium falciparum (Pf) infections was evaluated. Seventy-two newborns of mothers who were placental malaria negative (PM-) and of mothers who were PM+ with below (PM+ Lo) and above (PM + Hi) median placental parasitemia, were actively monitored during their first year of life. Median time to first PCR-detected Pf infection was shorter in PM + Lo infants (2...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317419/cohort-profile-effect-of-malaria-in-early-pregnancy-on-fetal-growth-in-benin-recipal-preconceptional-cohort
#6
Manfred Accrombessi, Emmanuel Yovo, Gilles Cottrell, Gino Agbota, Agnès Gartner, Yves Martin-Prevel, Nadia Fanou-Fogny, Diane Djossinou, Jennifer Zeitlin, Nicaise Tuikue-Ndam, Florence Bodeau-Livinec, Sandrine Houzé, Nicola Jackson, Paul Ayemonna, Achille Massougbodji, Michel Cot, Nadine Fievet, Valérie Briand
PURPOSE: REtard de Croissance Intra-uterin et PALudisme (RECIPAL) is an original preconceptional cohort designed to assess the consequences of malaria during the first trimester of pregnancy, which is a poorly investigated period in Africa and during which malaria may be detrimental to the fetus. PARTICIPANTS: For this purpose, a total of 1214 women of reproductive age living in Sô-Ava and Akassato districts (south Benin) were followed up monthly from June 2014 to December 2016 until 411 of them became pregnant...
January 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29317240/toxicity-and-cardiac-effects-of-acute-exposure-to-tryptophan-metabolites-on-the-kynurenine-pathway-in-early-developing-zebrafish-danio-rerio-embryos
#7
Michal Majewski, Natalia Kasica, Anna Jakimiuk, Piotr Podlasz
Defects in tryptophan metabolism on the l-kynurenine pathway (KP) are implicated in a number of human diseases, including chronic kidney disease, brain edema or injury, tuberculosis and malaria - as well as cancer, neurodegenerative and autoimmune disorders. However, it is unclear to what extent detrimental effects of exposure to tryptophan metabolites might impact the early development of organism. Thus, this study examined the effects of KP exposure in zebrafish embryos starting at the blastula period (4hpf) and the segmentation stage (24hpf)...
January 6, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29316929/molecular-identification-of-sulfadoxine-pyrimethamine-resistance-in-malaria-infected-women-who-received-intermittent-preventive-treatment-in-the-democratic-republic-of-congo
#8
Emrah Ruh, Jean Paul Bateko, Turgut Imir, Aysegul Taylan-Ozkan
BACKGROUND: Point mutations in Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes which confer resistance to sulfadoxine-pyrimethamine (SP) occur at increasing rates. The present study aimed to identify Pfdhfr and Pfdhps mutations in P. falciparum isolates recovered from women who received two doses of SP during pregnancy in Bandundu, the Democratic Republic of Congo (DRC). METHODS: A total of 48 women with confirmed P...
January 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29313480/malaria-and-iron-load-at-the-first-antenatal-visit-in-the-rural-south-kivu-democratic-republic-of-the-congo-is-iron-supplementation-safe-or-could-it-be-harmful
#9
Esto Bahizire, Umberto D'Alessandro, Michèle Dramaix, Nicolas Dauby, Fabrice Bahizire, Kanigula Mubagwa, Philippe Donnen
We investigated the relationship between malaria infection and iron status in 531 pregnant women in South Kivu, Democratic Republic of the Congo. Sociodemographic data, information on morbidity, and clinical data were collected. A blood sample was collected at the first antenatal visit to diagnose malaria and measure serum ferritin (SF), soluble transferrin receptor, C-reactive protein, and α1-acid-glycoprotein. Malaria prevalence was 7.5%. Median (interquartile range) SF (adjusted for inflammation) was significantly higher in malaria-infected (82...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29298303/-every-day-they-keep-adding-new-tools-but-they-don-t-take-any-away-producing-indicators-for-intermittent-preventive-treatment-for-malaria-in-pregnancy-iptp-from-routine-data-in-kenya
#10
George Okello, Rene Gerrets, Scholastica Zakayo, Sassy Molyneux, Caroline Jones
BACKGROUND: Intermittent preventive treatment for malaria in pregnancy (IPTp) is part of a multi-pronged strategy aimed at preventing malaria in pregnancy in areas of moderate to high transmission in sub-Saharan Africa. Despite being formally adopted as a malaria prevention policy over a decade ago, IPTp coverage has remained low. Recent demands for action have incorporated calls to strengthen IPTp monitoring and evaluation systems, including the use of routine data, to measure coverage, track implementation and identify roadblocks to improving uptake...
2018: PloS One
https://www.readbyqxmd.com/read/29297407/pregnancy-and-the-global-disease-burden
#11
Barbara J Sina
Pregnant women experience unique physiological changes pertinent to the effective prevention and treatment of common diseases that affect their health and the health of their developing fetuses. In this paper, the impact of major communicable (HIV/AIDS, tuberculosis, malaria, helminth infections, emerging epidemic viral infections) as well as non-communicable conditions (mental illness, substance abuse, gestational diabetes, eclampsia) on pregnancy is discussed. The current state of research involving pregnant women in these areas is also described, highlighting important knowledge gaps for the management of key illnesses that impact pregnancy globally...
December 14, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29287179/exposure-to-ddt-and-hypertensive-disorders-of-pregnancy-among-south-african-women-from-an-indoor-residual-spraying-region-the-vhembe-study
#12
Jennifer Murray, Brenda Eskenazi, Riana Bornman, Fraser W Gaspar, Madelein Crause, Muvhulawa Obida, Jonathan Chevrier
Indoor Residual Spraying (IRS), the use of insecticides inside residences for malaria control, may cause elevated exposure to insecticides such as dichlorodiphenyl trichloroethane (DDT). Evidence suggests that DDT exposure may increase blood pressure but no study has investigated associations with hypertensive disorders of pregnancy (HDP) in an IRS area. We measured the serum concentration of DDT and its breakdown product dichlorodiphenyl trichloroethylene (DDE) at the time of delivery among 733 rural South African women participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE)...
December 26, 2017: Environmental Research
https://www.readbyqxmd.com/read/29247172/host-iron-status-and-erythropoietic-response-to-iron-supplementation-determines-susceptibility-to-the-rbc-stage-of-falciparum-malaria-during-pregnancy
#13
Morgan M Goheen, Amat Bah, Rita Wegmüller, Hans Verhoef, Bakary Darboe, Ebrima Danso, Andrew M Prentice, Carla Cerami
Anaemia and malaria are both common in pregnant women in Sub-Saharan Africa. Previous evidence has shown that iron supplementation may increase malaria risk. In this observational cohort study, we evaluated P. falciparum pathogenesis in vitro in RBCs from pregnant women during their 2nd and 3rd trimesters. RBCs were collected and assayed before (n = 327), 14 days (n = 82), 49 days (n = 112) and 84 days (n = 115) after iron supplementation (60 mg iron as ferrous fumarate daily). P. falciparum erythrocytic stage growth in vitro is reduced in anaemic pregnant women at baseline, but increased during supplementation...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242251/equal-opportunity-equal-work-increasing-women-s-participation-in-the-u-s-president-s-malaria-initiative-africa-indoor-residual-spraying-project
#14
Abigail Donner, Allison Belemvire, Ben Johns, Keith Mangam, Elana Fiekowsky, Jayleen Gunn, Mary Hayden, Kacey Ernst
BACKGROUND: One of the primary control measures for malaria transmission is indoor residual spraying (IRS). Historically, few women have worked in IRS programs, despite the income-generating potential. Increasing women's roles in IRS requires understanding the barriers to women's participation and implementing measures to address them. The U.S. President's Malaria Initiative (PMI) Africa Indoor Residual Spraying (AIRS) Project is the largest implementer of IRS globally. To address gender inequity in IRS operations, PMI AIRS assessed the barriers to the participation of women and developed and implemented policies to address these barriers...
December 14, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29237461/systematic-literature-review-and-meta-analysis-of-the-efficacy-of-artemisinin-based-and-quinine-based-treatments-for-uncomplicated-falciparum-malaria-in-pregnancy-methodological-challenges
#15
Makoto Saito, Mary Ellen Gilder, François Nosten, Rose McGready, Philippe J Guérin
BACKGROUND: There is no agreed standard method to assess the efficacy of anti-malarials for uncomplicated falciparum in pregnancy despite an increased risk of adverse outcomes for the mother and the fetus. The aim of this review is to present the currently available evidence from both observational and interventional cohort studies on anti-malarial efficacy in pregnancy and summarize the variability of assessment and reporting found in the review process. METHODS: Efficacy methodology and assessment of artemisinin-based treatments (ABT) and quinine-based treatments (QBT) were reviewed systematically using seven databases and two clinical trial registries (protocol registration-PROSPERO: CRD42017054808)...
December 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29229635/plasmodium-falciparum-recrudescence-two-years-after-a-first-treated-uncomplicated-infection-without-return-in-a-malaria-endemic-area
#16
Denis Malvy, Marylin Torrentino-Madamet, Coralie L'Ollivier, Marie-Catherine Receveur, Fakhri Jeddi, Laurence Delhaes, Renaud Piarroux, Pascal Millet, Bruno Pradines
We report here evidence, confirmed by the lack of travel activity outside of France and genetic diversity analysis using polymorphic microsatellite markers, that Plasmodium falciparum malaria infection effectively treated with an artemisinin-based combination can remain dormant and relapse during pregnancy at least 2 years after treatment.
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29221497/low-serum-ferritin-and-g6pd-deficiency-as-potential-predictors-of-anaemia-in-pregnant-women-visiting-prime-care-hospital-enugu-nigeria
#17
Godwill Azeh Engwa, Marcellus Unaegbu, Marian N Unachukwu, Mary-Gloria C Njoku, Kingsley N Agbafor, Wilfred Fon Mbacham, Anthony Okoh
OBJECTIVES: Though iron deficiency is known to be a major risk factor of anaemia, the association of G6PD deficiency and malaria with anaemia still remains unclear. Hence, a cross-sectional study involving 95 pregnant women visiting Prime Care Hospital in Trans-Ekulu region of Enugu Nigeria was conducted to determine possible predictors of anaemia in pregnancy. RESULTS: The prevalence of anaemia, malaria and G6PD deficiency were 53.7, 12.6 and 60% respectively. Low serum ferritin (OR 5...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29213169/clinical-profile-of-neural-tube-defects-in-sudanese-children-is-malaria-a-risk-factor
#18
Basma Sadik, Haydar E Babikir, Mohammed A R Arbab
Neural tube defects (NTDs) are one of the most common structural malformations in human kind. It is a public health problem with great impact on the child, parents and the community at large. The aim is to study the epidemiological profile and patterns of NTDs in under five-year of age Sudanese children who attended the neurosurgical clinic at the National Centre of Neurological Sciences (NCNS), Khartoum during the period from March 2014 to December 2014. This was a prospective cross-sectional study conducted at the neurosurgery clinic in NCNS, Khartoum...
2017: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/29210351/seasonal-dynamics-of-malaria-in-pregnancy-in-west-africa-evidence-for-carriage-of-infections-acquired-before-pregnancy-until-first-contact-with-antenatal-care
#19
Isha Berry, Patrick Walker, Harry Tagbor, Kalifa Bojang, Sheick Oumar Coulibaly, Kassoum Kayentao, John Williams, Abraham Oduro, Paul Milligan, Daniel Chandramohan, Brian Greenwood, Matthew Cairns
In malaria-endemic areas, Plasmodium falciparum prevalence is often high in young women because of 1) low use of insecticide-treated nets before their first pregnancy and 2) acquired immunity, meaning infections are asymptomatic and thus untreated. Consequently, a common source of malaria in pregnancy (MiP) may be infected women becoming pregnant, rather than pregnant women becoming infected. In this study, prevalence of infection was determined by microscopy at first antenatal care (ANC) visit in primigravidae and secundigravidae in Ghana, Burkina Faso, Mali, and The Gambia, four countries with strong seasonal variations in transmission...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29192419/the-course-of-pregnancy-and-delivery-in-a-patient-with-malaria
#20
Michał Krekora, Katarzyna Zych-Krekora, Maciej Słodki, Mariusz Grzesiak, Maria Respondek-Liberska
Malaria is one of the most common lethal parasitic diseases. Infection is transmitted when an infected female mosquito bites a human introducing the sporozoites into human blood. The article presents the course of pregnancy and delivery in a patient complicated by Plasmodium infection. The patient had repetitive several trips to Tanzania over a short time period before she developed the condition. She had been taking antimalarial medication (proguanil-atovaquone) in a prophylactic dose during and after her first travel to Tanzania...
2017: Ginekologia Polska
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