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voluven orthopedic surgery

Sweeta D Gandhi, Richard B Weiskopf, Cornelius Jungheinrich, Robert Koorn, Diane Miller, Robert E Shangraw, Donald S Prough, Daniela Baus, Frank Bepperling, David C Warltier
BACKGROUND: The purpose of this study was to test the equivalence of efficacy and compare the safety of the 6% hydroxyethyl starches (HES) Voluven (HES 130/0.4; Fresenius Kabi, Bad Homburg, Germany) and hetastarch (HES 670/0.75 in saline) for intravascular volume replacement therapy during major orthopedic surgery. METHODS: In a prospective, controlled, randomized, double-blind, multicenter trial of patients undergoing major orthopedic surgery, 49 patients were treated with HES 130/0...
June 2007: Anesthesiology
O Langeron, M Doelberg, E T Ang, F Bonnet, X Capdevila, P Coriat
UNLABELLED: Hydroxyethyl starch (HES) solutions are effective plasma volume expanders. Impairment of coagulation occurs with large HES volumes infused perioperatively. Therefore, a lower substituted novel HES (Voluven; Fresenius Kabi, Bad Homburg, Germany) was developed to minimize hemostatic interactions, and was compared with HAES-steril (Fresenius Kabi) (pentastarch) regarding safety and efficacy. We performed a prospective, randomized, double-blinded study in 100 major orthopedic surgery patients...
April 2001: Anesthesia and Analgesia
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