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https://www.readbyqxmd.com/read/28230569/procedure-oriented-torsional-anatomy-of-the-hand-for-spasticity-injection
#1
Joslyn John, John Cianca, Faye Chiou-Tan, Sindhu Pandit, Erin Furr-Stimming, Katherine H Taber
OBJECTIVES: To provide musculoskeletal ultrasound (MSKUS) images of hand anatomy in the position of hemiparetic flexion as a reference for spasticity injections. After a stroke, spasticity can result in anatomic distortion of the hand. Spasticity may require treatment with botulinum toxin or phenol injections. Anatomic distortion may decrease the accuracy of injections. Standard anatomic references are of limited utility because they are not in this spastic hemiparetic position. There presently is no anatomic reference in the literature for these spastic postures...
February 23, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28229127/the-application-of-retinal-fundus-camera-imaging-in-dementia-a-systematic-review
#2
REVIEW
Sarah McGrory, James R Cameron, Enrico Pellegrini, Claire Warren, Fergus N Doubal, Ian J Deary, Baljean Dhillon, Joanna M Wardlaw, Emanuele Trucco, Thomas J MacGillivray
INTRODUCTION: The ease of imaging the retinal vasculature, and the evolving evidence suggesting this microvascular bed might reflect the cerebral microvasculature, presents an opportunity to investigate cerebrovascular disease and the contribution of microvascular disease to dementia with fundus camera imaging. METHODS: A systematic review and meta-analysis was carried out to assess the measurement of retinal properties in dementia using fundus imaging. RESULTS: Ten studies assessing retinal properties in dementia were included...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28228411/retinal-vascular-calibre-changes-after-intravitreal-bevacizumab-or-dexamethasone-implant-treatment-for-diabetic-macular-oedema
#3
Sanjeewa S Wickremasinghe, Samantha Fraser-Bell, Elizabeth Alessandrello, Hemal Mehta, Mark C Gillies, Lyndell L Lim
PURPOSE: To compare changes in retinal vascular calibre after 2 years of treatment with intravitreal bevacizumab (BVZ) or dexamethasone implant (DEX) in patients with centre-involving diabetic macular oedema (DMO). METHODS: At baseline, 88 eyes of 61 patients with DMO were recruited in a prospective, multicentre, randomised, single-masked clinical trial. Of these subjects, 22 BVZ-treated (52%) and 22 DEX-treated (48%) eyes of 34 patients (56%) had gradable retinal photographs at both the baseline and 24-month visits...
February 22, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28228404/endothelial-colony-forming-cells-ameliorate-endothelial-dysfunction-via-secreted-factors-following-ischemia-reperfusion-injury
#4
Jason A Collett, Purvi Mehrotra, Allison Crone, W Christopher Shelley, Mervin C Yoder, David P Basile
Damage to endothelial cells contributes to acute kidney injury (AKI) by leading to impaired perfusion. Endothelial colony-forming cells (ECFCs) are endothelial precursor cells with high proliferative capacity, pro-angiogenic activity, and in vivo vessel forming potential. We hypothesized that ECFCs may ameliorate the degree of AKI and/or promote repair of the renal vasculature following ischemia/reperfusion (I/R). Rat pulmonary microvascular ECs (PMVEC) with high proliferative potential were compared with pulmonary artery ECs (PAEC) with low proliferative potential in rats subjected to renal I/R...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28228278/immunopathogenesis-of-rheumatoid-arthritis
#5
REVIEW
Gary S Firestein, Iain B McInnes
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that together propogate chronic inflammation and articular destruction. A pre-RA phase lasting months to years may be characterized by the presence of circulating autoantibodies, increasing concentration and range of inflammatory cytokines and chemokines, and altered metabolism...
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28227912/a-hybrid-discrete-continuous-model-of-in-vitro-spheroid-tumor-growth-and-drug-response
#6
Giorgos Tzedakis, Evangelos Liapis, Eleftheria Tzamali, Giannis Zacharakis, Vangelis Sakkalis, Giorgos Tzedakis, Evangelos Liapis, Eleftheria Tzamali, Giannis Zacharakis, Vangelis Sakkalis, Giannis Zacharakis, Vangelis Sakkalis, Evangelos Liapis, Giorgos Tzedakis, Eleftheria Tzamali
Anti-cancer therapy efficacy in solid tumors mainly depends on drug transportation through the vasculature system and the extracellular matrix, on diffusion gradients and clonal heterogeneity within the tumor mass, as well as on the responses of the individual tumor cells to drugs and their interactions with each other and their local microenvironment. In this work, we develop a mathematical predictive model for tumor growth and drug response based on 3D spheroids experiments that possess several in vivo features of tumors and are considered better for drug screening...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227660/robot-assisted-retinal-vein-cannulation-with-force-based-puncture-detection-micron-vs-the-steady-hand-eye-robot
#7
Berk Gonenc, Nhat Tran, Peter Gehlbach, Russell H Taylor, Iulian Iordachita, Berk Gonenc, Nhat Tran, Peter Gehlbach, Russell H Taylor, Iulian Iordachita, Nhat Tran, Russell H Taylor, Iulian Iordachita, Berk Gonenc, Peter Gehlbach
Retinal vein cannulation is a demanding procedure where therapeutic agents are injected into occluded retina veins. The feasibility of this treatment is limited due to challenges in identifying the moment of venous puncture, achieving cannulation and maintaining it throughout the drug delivery period. In this study, we integrate a force-sensing microneedle with two distinct robotic systems: the handheld micromanipulator Micron, and the cooperatively controlled Steady-Hand Eye Robot (SHER). The sensed tool-to-tissue interaction forces are used to detect venous puncture and extend the robots' standard control schemes with a new position holding mode (PHM) that assists the operator hold the needle position fixed and maintain cannulation for a longer time with less trauma on the vasculature...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227567/a-method-to-assess-the-location-and-positional-stability-of-supra-choroidal-retinal-neuroprostheses
#8
Barry S Gow, Gregg J Suaning, Barry S Gow, Gregg J Suaning, Barry S Gow, Gregg J Suaning
Electrical stimulation of the retina is now firmly established as a means of restoration of rudimentary vision for blindness particularly that caused by retinitis pigmentosa. Of the various approaches, the novel positioning of an ultra-thin stimulating electrode array (SEA) posterior to the choroid has shown promising results. Following their implantation, reliable imaging methods are essential to establish the SEA's location relative to the optic disk and retinal vasculature. Because the opacity of the choroid precludes the use of conventional light-based fundus imaging, we developed an instrument (Wangiscope) that relies on infra-red illumination from LEDs...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227459/leg-fluid-accumulation-during-prolonged-sitting
#9
Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Azadeh Yadollahi, Jonathan Rubianto, Milos Popovic
The accumulation of fluid in the legs due to sedentariness can be a health risk in extreme cases. Negative health impacts associated with leg fluid accumulation include leg edema and risk of blood clots. Furthermore, fluid accumulating in the legs is accompanied by fluid shift into the upper body which is also associated with health risks such as: increased blood pressure when lying down, respiratory problems in people with heart failure, and increased sleep apnea. Understanding the pattern by which fluid accumulates in the legs can aid in the development of devices for reducing leg fluid accumulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227388/learning-to-distinguish-cerebral-vasculature-data-from-mechanical-chatter-in-india-ink-images-acquired-using-knife-edge-scanning-microscopy
#10
Michael R Nowak, Yoonsuck Choe, Michael R Nowak, Yoonsuck Choe, Michael R Nowak, Yoonsuck Choe
We introduce a simple, yet effective, procedure for accurate classification of connected components embedded in biological images. In our method, a training set is generated from user-delineated features of manually-labeled examples; we subsequently train a classifier using the resultant training set. The overall process is described using imaging data acquired from an India-ink perfused C57BL/6J mouse brain using Knife Edge Scanning Microscopy. We illustrate the procedure through segmentation of cerebral vasculature structures from mechanical noise using trained classifiers...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227363/3d-gabor-wavelet-based-vessel-filtering-of-photoacoustic-images
#11
Israr Ul Haq, Ryo Nagoaka, Takahiro Makino, Takuya Tabata, Yoshifumi Saijo, Israr Ul Haq, Ryo Nagoaka, Takahiro Makino, Takuya Tabata, Yoshifumi Saijo, Ryo Nagoaka, Yoshifumi Saijo, Takahiro Makino, Takuya Tabata
Filtering and segmentation of vasculature is an important issue in medical imaging. The visualization of vasculature is crucial for the early diagnosis and therapy in numerous medical applications. This paper investigates the use of Gabor wavelet to enhance the effect of vasculature while eliminating the noise due to size, sensitivity and aperture of the detector in 3D Optical Resolution Photoacoustic Microscopy (OR-PAM). A detailed multi-scale analysis of wavelet filtering and Hessian based method is analyzed for extracting vessels of different sizes since the blood vessels usually vary with in a range of radii...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227209/high-speed-in-vivo-imaging-of-retinal-hemodynamics-in-a-rodent-model-of-hypertension
#12
Mahdieh Rezaeian, Dana Georgevsky, S Mojtaba Golzan, Stuart L Graham, Mahdieh Rezaeian, Dana Georgevsky, S Mojtaba Golzan, Stuart L Graham, Dana Georgevsky, Mahdieh Rezaeian, S Mojtaba Golzan, Stuart L Graham
The eye is the only organ through which microcirculation can be visualized non-invasively. This unique feature makes the eye and specifically retinal vasculature an excellent target area to monitor and study micro-vascular damage in systemic diseases. Dynamic (real-time) changes of retinal vessels have been shown to be more specific to the disease in comparison with static measurements. In this study we utilize high speed imaging (i.e. 125 fps) to study and derive dynamic changes of retinal vessels in a rat model of hypertension...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227085/an-object-oriented-model-of-the-cardiopulmonary-system-with-emphasis-on-the-gravity-effect
#13
Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Berno Misgeld
We introduce a novel comprehensive model of the cardiopulmonary system with emphasis on perfusion and ventilation distribution along the vertical thorax axis under the gravity effect. By using an object-oriented environment, the complex physiological system can be represented by a network of electrical, lumped-element compartments. The lungs are divided into three zones: upper, middle, and lower zone. Blood flow increases with the distance from the apex to the base of the lungs. The upper zone is characterized by a complete collapse of the pulmonary capillary vasculature; thus, there is no flow in this zone...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227067/computational-estimation-of-the-severity-of-coronary-lesions-with-intravascular-ultrasound-images-a-pilot-study
#14
Panagiotis K Siogkas, Michail I Papafaklis, Bill D Gogas, Habib Samady, Lampros K Michalis, Dimitrios I Fotiadis, Panagiotis K Siogkas, Michail I Papafaklis, Bill D Gogas, Habib Samady, Lampros K Michalis, Dimitrios I Fotiadis, Bill D Gogas, Habib Samady, Michail I Papafaklis, Dimitrios I Fotiadis, Panagiotis K Siogkas, Lampros K Michalis
The fast and accurate hemodynamic functional assessment of the coronary vasculature is of utmost importance in clinical practice due to the fact that Cardiovascular Diseases have become the leading cause of death globally. In this work we propose a novel method that combines two of the most efficient methods of hemodynamic status assessment of coronary arteries, Intravascular UtraSound and virtual Functional Assessment Index, an index that correlates well to the measured Fractional Flow Reserve. One Left Anterior Descending segment was reconstructed both in a straight manner (using only IVUS images) as well as using the actual 3D geometry of the vessel (using IvUS images combined with the respective coronary angiographic images [2])...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225721/superficial-foveal-avascular-zone-determined-by-optical-coherence-tomography-angiography-before-and-after-macular-hole-surgery
#15
Takayuki Baba, Masato Kakisu, Tomohiro Nizawa, Toshiyuki Oshitari, Shuichi Yamamoto
PURPOSE: To determine the size of the superficial foveal avascular zone (FAZ) by optical coherence tomography angiography before and after surgery for an idiopathic macular hole. METHODS: A retrospective, observational case series, in which 16 eyes of 16 patients with an idiopathic macular hole were studied. Pars plana vitrectomy was performed with internal limiting membrane peeling. The foveal retinal vasculature was examined by optical coherence tomography angiography, and the area of the superficial FAZ was determined before, and at 1 and 3 months after the surgery...
March 2017: Retina
https://www.readbyqxmd.com/read/28224304/visualization-of-draining-vein-in-focal-nodular-hyperplasia-by-superb-microvascular-imaging-report-of-two-cases
#16
Hiroko Naganuma, Hideaki Ishida, Masahiro Ogawa, Katsunori Suzuki
Focal nodular hyperplasia (FNH) is the second most common benign tumor of the liver, and diagnosis and follow-up without invasive procedures are now highly recommended. FNH shows a characteristic vascular structure called "spoke-wheel appearance". However, this appearance relies on the mode of the feeding artery, and the mode of the draining vein has not been sufficiently studied until recently. Superb microvascular imaging (SMI) is a new Doppler technology designed to improve visualization of the blood flow, especially slow flow signals from fine vessels, using a new algorithm...
February 21, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28223275/vascular-cxcr4-expression-promotes-vessel-sprouting-and-sensitivity-to-sorafenib-treatment-in-hepatocellular-carcinoma
#17
Jing Xu, Jing Liang, Ya-Ming Meng, Jing Yan, Xin-Juan Yu, Chao-Qun Liu, Li Xu, Shi-Mei Zhuang, Limin Zheng
PURPOSE: Chemokine receptor CXCR4 is known to be involved in both developmental and adult angiogenesis; however, its role in tumor angiogenesis remains largely unknown. Here the role of vascular CXCR4 in regulating vascular structure in HCC was assessed and the clinical value of CXCR4 was explored. EXPERIMENTAL DESIGN: The expression of CXCR4 in hepatocellular carcinoma (HCC) was determined by immunohistochemistry and immunofluorescence. Characteristics of CXCR4+ cells were determined by in vitro and mice experiments...
February 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28223171/how-tumour-induced-vascular-changes-alter-angiogenesis-insights-from-a-computational-model
#18
A Stéphanou, A C Lesart, J Deverchère, A Juhem, A Popov, F Estève
A computational model was developed to describe experimentally observed vascular changes induced by the introduction of a tumour on a mouse equipped with a dorsal skinfold chamber. The vascular structure of the host tissue was segmented from in vivo images and transposed into the computational framework. Simulations of tumour-induced vascular changes were performed and include the destabilizing effects of the growth factor VEGF on the integrity of the vessels walls. The integration of those effects, that include alteration of the vessel wall elasticity and wall breaching, were required to realistically reproduce the experimental observations...
February 20, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28223053/diabetes-upregulation-of-cyclooxygenase-2%C3%A2-contributes-to-altered-coronary-reactivity-after-cardiac-surgery
#19
Jun Feng, Kelsey Anderson, Arun K Singh, Afshin Ehsan, Hunter Mitchell, Yuhong Liu, Frank W Sellke
BACKGROUND: We hypothesized that upregulation of inducible cyclooxygenase 2 (COX-2) contributes to altered coronary arteriolar reactivity early after cardioplegic arrest and cardiopulmonary bypass (CP/CPB) in patients with diabetes mellitus who are undergoing cardiac surgery. METHODS: The right atrial tissue samples of nondiabetes (ND), controlled diabetes (CDM), and uncontrolled diabetes (UDM) patients undergoing cardiac surgery were harvested before and after CP/CPB...
February 18, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28222326/crossing-kingdoms-using-decellularized-plants-as-perfusable-tissue-engineering-scaffolds
#20
Joshua R Gershlak, Sarah Hernandez, Gianluca Fontana, Luke R Perreault, Katrina J Hansen, Sara A Larson, Bernard Y K Binder, David M Dolivo, Tianhong Yang, Tanja Dominko, Marsha W Rolle, Pamela J Weathers, Fabricio Medina-Bolivar, Carole L Cramer, William L Murphy, Glenn R Gaudette
Despite significant advances in the fabrication of bioengineered scaffolds for tissue engineering, delivery of nutrients in complex engineered human tissues remains a challenge. By taking advantage of the similarities in the vascular structure of plant and animal tissues, we developed decellularized plant tissue as a prevascularized scaffold for tissue engineering applications. Perfusion-based decellularization was modified for different plant species, providing different geometries of scaffolding. After decellularization, plant scaffolds remained patent and able to transport microparticles...
February 10, 2017: Biomaterials
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