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Rodrigo Mardones, Alessio Giai Via, Claudio Jofré, José Minguell, Claudio Rodriguez, Alexander Tomic, Matias Salineros
BACKGROUND: Chondral injuries are commonly related to poor clinical outcome, but recent data showed some improvements in function and pain after hip arthroscopy. Cell-based therapies represent an appealing alternative strategy for cartilage regeneration, and interesting results have been recently reported after intra-articular injections of mesenchymal stem cells (MSCs). The results of hip arthroscopy for femoroacetabular impingement (FAI) and intra-articular injections of autologous expanded bone marrow - MSCs (BM-MSCs) are reported in this retrospective study...
July 2016: Muscles, Ligaments and Tendons Journal
Alexandra Giraldo, Sergi Benavente, Mónica Ramos, Ramona Vergés, Odimar Coronil, Lina Arbeláez, Xavier Maldonado, Manuel Altabas, Meritxell Mollà, Victoria Reyes, Begoña Navalpotro, Jordi Giralt
AIM: To analyze the effect of radiotherapy (RT) in patients with metastatic spinal cord compression (MSCC) and poor prognosis in our center. BACKGROUND: RT is an effective treatment for MSCC. MATERIALS AND METHODS: Prospective evaluation on patients with MSCC and limited survival (according to Rades' scale), and treated with single-dose 8 Gy RT (February 2013-August 2014). Pain, ambulatory status and sphincter control were recorded. Pain relief was evaluated following the International Bone Metastases Consensus Working Party Guidelines...
January 2017: Reports of Practical Oncology and Radiotherapy
Patrick Joseph Maher, Alisha Emily Cutler Brown, Medley O'Keefe Gatewood
BACKGROUND: Urinalysis testing is frequently ordered in the emergency department (ED), but contamination of urine specimens limits the interpretation of results. The mid-stream, clean-catch (MSCC) procedure for urine specimen collection is recommended to decrease contamination rates, but without instructions this procedure has poor compliance. OBJECTIVE: To evaluate the effectiveness of written instructions alone, we analyzed the rate of specimen contamination, defined by presence of squamous epithelial cells (SECs) and culture results, in the ED after posting information on the MSCC procedure...
November 1, 2016: Journal of Emergency Medicine
Dirk Rades, Stefan Janssen, Antonio Jose Conde-Moreno, Jon Cacicedo, Michaela Metz, Theo Veninga, Barbara Segedin, Volker Rudat, Steven E Schild
INTRODUCTION: Radiotherapy alone still is the most commonly delivered treatment modality for metastatic spinal cord compression (MSCC). MSCC is an emergency situation, which requires treatment as soon as possible. When radiotherapy is performed with the most commonly used approach 10 × 3 Gy (30 Gy in 10 fractions) over 2 weeks, the question has been asked whether an overall treatment time (OTT) of 14-15 days including two weekends without irradiation leads to worse outcomes than OTT of 12 days (beginning of radiotherapy on a Monday resulting in only one weekend break)? METHODS: A total of 412 patients with MSCC were included in this retrospective study...
November 2, 2016: Journal of Medical Imaging and Radiation Oncology
M Ohashi, T Hirano, K Watanabe, K Katsumi, H Shoji, A Sano, H Tashi, I Takahashi, M Wakasugi, Y Shibuya, N Endo
STUDY DESIGN: Retrospective multicenter study. OBJECTIVES: To analyze the predictive factors for postoperative ambulatory recovery in paretic non-ambulatory patients with metastatic spinal cord compression (MSCC). SETTING: Japan. METHODS: Eighty-two consecutive patients (74.4% men; mean age, 66.2 years) who could not walk before surgery due to cervical or thoracic MSCC and underwent posterior decompressive surgery between 2003 and 2014 were included...
October 18, 2016: Spinal Cord
M M Gestaut, N Thawani, S Kim, V R Gutti, A Morrow, R A Ward, J H Huang, M K Patel
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Søren S Morgen, Svend A Engelholm, Claus F Larsen, Rikke Søgaard, Benny Dahl
OBJECTIVE: Improvements in cancer treatment have resulted in an increased number of patients with metastatic spinal cord compression (MSCC). Because patients with MSCC often have a limited expected survival time, maintenance of a high functional level and quality of life are important. However, there is limited information about health-related quality of life (HRQoL) in patients with MSCC. The aim of this study was to examine the feasibility of routine assessment of HRQoL based on the Euroqol-5 dimensions (EQ-5D) questionnaire in a cohort of patients consecutively admitted for evaluation of acute symptoms of MSCC...
August 2016: Orthopaedic Surgery
Cameron Trodello, Jon-Paul Pepper, Michael Wong, Ashley Wysong
BACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and metastasizes in 2% to 5% of cases. OBJECTIVE: Systematic evaluation of published cases of metastatic cSCC (mSCC) treated with cisplatin or cetuximab from 1989 to 2014. MATERIALS AND METHODS: A literature search was performed to identify cases of mSCC treated with cisplatin or cetuximab. Patient demographics, tumor characteristics, response rates, and disease-free survivals were extracted...
January 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Aria Nouri, Lindsay Tetreault, Kristian Dalzell, Juan J Zamorano, Michael G Fehlings
BACKGROUND: Degenerative cervical myelopathy encompasses a group of conditions resulting in progressive spinal cord injury through static and dynamic compression. Although a constellation of changes can present on magnetic resonance imaging (MRI), the clinical significance of these findings remains a subject of controversy and discussion. OBJECTIVE: To investigate the relationship between clinical presentation and quantitative MRI features in patients with degenerative cervical myelopathy...
September 5, 2016: Neurosurgery
Stefan Janssen, Tobias Bartscht, Dirk Rades
BACKGROUND/AIM: Adrenocortical cancer is a rare aggressive type of cancer. The prognosis is poor, particularly for metastatic disease. This study focused on metastatic spinal cord compression (MSCC) from adrenocortical carcinoma. PATIENTS AND METHODS: Data of three patients who received palliative irradiation of MSCC from adrenocortical carcinoma were retrospectively analyzed for motor function, ambulatory status and survival. RESULTS: One patient died before completion of radiotherapy...
September 2016: In Vivo
Sunil Kukreja, Jan Schwab, Francis Farhadi
INTRODUCTION: The influence of initial clinical and imaging parameters on long-term outcomes following spinal cord injury (SCI) has been examined in previous studies, often with inconsistent or contradictory findings. In this study, we evaluated a comprehensive set of admission parameters and analyzed their relationships with long-term neurological recovery. METHODS: Institutional databases were used to retrospectively identify consecutive patients with cervical SCI admitted between 2008 and 2015...
August 2016: Neurosurgery
Bowen Deng, Zhigang Chen, Muxing Gao, Yuqiao Song, Kaiyuan Zheng, Juanjuan Tang, Wei Xiao, Xuhui Mao, Dihua Wang
Electrochemical transformation of CO2 into functional materials or fuels (i.e., carbon, CO) in high temperature molten salts has been demonstrated as a promising way of carbon capture, utilisation and storage (CCUS) in recent years. In a view of continuous operation, the electrolysis process should match very well with the CO2 absorption kinetics. At the same time, in consideration of the energy efficiency, a molten salt electrochemical cell running at lower temperature is more beneficial to a process powered by the fluctuating renewable electricity from solar/wind farms...
August 15, 2016: Faraday Discussions
Louisa Bolm, Stefan Janssen, Tobias Bartscht, Dirk Rades
AIM: Seminomas are very radiosensitive tumors. Therefore, patients with malignant spinal cord compression (MSCC) from seminoma may not require for neurosurgery in addition to radiotherapy. In this study, radiotherapy alone was evaluated in young men with MSCC from seminoma. PATIENTS AND METHODS: Four young men with MSCC due to vertebral lesions from metastatic seminoma received radiotherapy alone. The impact of radiotherapy on motor function and gait function, local control of MSCC and survival were retrospectively evaluated...
April 2016: Anticancer Research
Mingxing Lei, Jianjie Li, Yaosheng Liu, Weigang Jiang, Shubin Liu, Shiguo Zhou
STUDY DESIGN: A retrospective study. OBJECTIVE: This study aims to develop a new scoring system that can guild surgeons to select the best candidates for decompressive surgery in patients with metastatic spinal cord compression (MSCC). SUMMARY OF BACKGROUND DATA: Predicting survival and functional outcome is essential when selecting the individual treatment for patients with MSCC. The criteria for identifying MSCC patients who are most likely to benefit from decompressive surgery remain unclear...
September 15, 2016: Spine
M Lei, Y Liu, S Liu, L Wang, S Zhou, J Zhou
PURPOSE: The criteria for identifying lung cancer patients with metastatic spinal cord compression (MSCC) who may benefit from decompressive surgery remains unclear. This study aims to create a new therapeutic strategy which can guild surgeons to select the individual treatment for MSCC patients from lung cancer. METHODS: We retrospectively assessed 73 consecutive lung cancer patients who were treated with decompressive surgery for MSCC. Twelve preoperative characteristics were analyzed for postoperative survival...
May 2016: European Journal of Surgical Oncology
Shuai Han, Xinghai Yang, Dongjie Jiang, Wang Zhou, Tielong Liu, Wangjun Yan, Ting Wang, Li Cheng, Jianru Xiao
STUDY DESIGN: A retrospective study. OBJECTIVE: The aim of this study was to discuss the factors that may affect surgical outcomes of patient with diffuse large B-cell lymphoma (DLBCL)-associated metastatic spinal cord compression (MSCC). SUMMARY OF BACKGROUND DATA: DLBCL in the spine is rare and minimal information has been published in the literature regarding this subject. Although DLBCL is highly sensitive to both chemotherapy and radiotherapy, surgical decompression is recommended in the treatment of DLBCL-associated MSCC...
August 1, 2016: Spine
Jinwei Ying, Xiaojun Zhou, Minyu Zhu, Yang Zhou, Kelun Huang, Beibei Zhou, Honglin Teng
BACKGROUND/AIMS: This study aimed at assessing the feasibility of diffusion tensor imaging (DTI) in multilevel cervical spondylotic myelopathy (MCSM) and quantifying the association between DTI parameters and neuronal status as a whole. METHODS: Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were obtained from 32 patients with MCSM and 21 healthy volunteers at each level. The extent of cervical cord compression was evaluated by maximum spinal cord compression (MSCC)...
2016: European Neurology
Mary Harris
Malignant spinal cord compression (MSCC) is a devastating complication of metastatic cancer. The majority of existing studies focus on treatment guidelines for MSCC, with little emphasis on the impact that MSCC has on quality of life (QoL) for this patient group. This literature review aims to critically appraise available literature focusing on QoL for patients with MSCC. Relevant literature was identified from key electronic databases. A dearth of credible studies representative of the patient population with MSCC was found...
January 2016: International Journal of Palliative Nursing
Dirk Rades, Antonio J Conde-Moreno, Jon Cacicedo, Barbara Szegedin, Steven E Schild
AIM: To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma. PATIENTS AND METHODS: In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates. RESULTS: Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0...
January 2016: Anticancer Research
Kazuya Oshima, Nobuyuki Hashimoto, Tsukasa Sotobori, Susumu Joyama, Hironobu Tanigami, Katsuyuki Nakanishi, Nobuhito Araki
STUDY DESIGN: This is a retrospective, single-institute, radiographical study. OBJECTIVE: The study aimed to determine the correlation of magnetic resonance imaging (MRI) findings observed in metastatic spinal cord compression (MSCC) with post-treatment ambulatory status. SUMMARY OF BACKGROUND DATA: Previous studies have reported various predictors of ambulatory outcome in patients with MSCC, but the relationship between the MRI features and post-treatment ambulatory function remains to be elucidated...
April 2016: Spine
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