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https://www.readbyqxmd.com/read/29764185/management-of-metastatic-spinal-cord-compression-among-veterans-health-administration-radiation-oncologists
#1
Ruchika Gutt, Sheeta Malhotra, Shruti Jolly, Drew Moghanaki, Alice V Cheuk, Helen Fosmire, Maria Kelly, Lori Hoffman-Hogg, Stephen Lutz, Mitchell Anscher, George Dawson
BACKGROUND: Optimal management of metastatic spinal cord compression (MSCC) improves functional outcomes in patients with metastatic disease. This survey study evaluated management of MSCC by Veterans Health Administration (VHA) radiation oncologists (ROs), to determine whether management of MSCC correlates with American College of Radiology (ACR) guidelines, and to compare times to initiation of treatment between surgery and radiotherapy (RT). METHODS: Surveys emailed to 79 VHA ROs included questions on steroid use, surgical care, palliative care, fractionation of irradiation, re-irradiation, and management of common MSCC case scenarios...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29742559/pd-l1-expression-is-increased-in-metastasizing-squamous-cell-carcinomas-and-their-metastases
#2
Irene García-Díez, Eugenia Hernández-Ruiz, Evelyn Andrades, Javier Gimeno, Carla Ferrándiz-Pulido, Mireia Yébenes, Vicenç García-Patos, Ramón M Pujol, Inmaculada Hernández-Muñoz, Agustí Toll
Programmed cell death ligand 1 (PD-L1) expression by tumor cells plays an important role in the inhibition of T cell-mediated immune response in cancer. PD-L1 expression by tumor cells has been linked to poor prognosis in a wide variety of cancers. However, PD-L1 expression in cutaneous squamous cell carcinoma (cSCC) has been scarcely studied, and its role as a prognosis biomarker remains controversial. The association of PD-L1 expression and the metastatic risk in a series of cSCC was assessed. PD-L1 and CD8 immunostainings of full excision sections of 99 primary tumors and 24 lymphatic metastases were semiquantitatively evaluated...
May 3, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29733989/prognostic-factors-of-ambulatory-status-for-patients-with-metastatic-spinal-cord-compression-a-systematic-review-and-meta-analysis
#3
Yongheng Liu, Yongcheng Hu, Xionggang Yang, Dengxing Lun, Feng Wang, Li Yang, Hao Zhang, Jiangtao Feng, Kunchi Hua
BACKGROUND: This study aimed to identify prognostic factors for functional outcome of metastatic spinal cord compression (MSCC). METHODS: All full texts in English regarding the prognostic factors for functional outcome of MSCC, published between January 2007 and October 2017, were identified using the electronic databases PubMed, Embase, and the Cochrane Library. An exploratory meta-analysis was also conducted when appropriate data were available. RESULT: A total of 25 studies, involving 4897 patients, met the inclusion criteria...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29671593/moving-beyond-the-van-krevelen-diagram-a-new-stoichiometric-approach-for-compound-classification-in-organisms
#4
Albert Rivas-Ubach, Yina Liu, Thomas S Bianchi, Nikola Tolić, Christer Jansson, Ljiljana Paša-Tolić
van Krevelen diagrams (O/C vs H/C ratios of elemental formulas) have been widely used in studies to obtain an estimation of the main compound categories present in environmental samples. However, the limits defining a specific compound category based solely on O/C and H/C ratios of elemental formulas have never been accurately listed or proposed to classify metabolites in biological samples. Furthermore, while O/C vs H/C ratios of elemental formulas can provide an overview of the compound categories, such classification is inefficient because of the large overlap among different compound categories along both axes...
May 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29665511/advanced-cutaneous-squamous-cell-carcinoma-a-retrospective-analysis-of-patient-profiles-and-treatment-patterns-results-of-a-non-interventional-study-of-the-decog
#5
Uwe Hillen, Ulrike Leiter, Sylvie Haase, Roland Kaufmann, Jürgen Becker, Ralf Gutzmer, Patrick Terheyden, Albrecht Krause-Bergmann, Hans-Joachim Schulze, Jessica Hassel, Nina Lahner, Uwe Wollina, Fabian Ziller, Jochen Utikal, Christine Hafner, Jens Ulrich, Hans-Günther Machens, Carsten Weishaupt, Axel Hauschild, Peter Mohr, Claudia Pföhler, Jan Maurer, Patrick Wolff, Christine Windemuth-Kieselbach, Dirk Schadendorf, Elisabeth Livingstone
BACKGROUND: Advanced cutaneous squamous cell carcinoma (aSCC) is an area of unmet medical need and no treatment standards are established. Recently, an anti-PD-1 inhibitor received FDA breakthrough therapy designation. The aim of the study was to describe the clinical course, therapeutic management and prognosis of aSCC under real-life conditions. PATIENTS AND METHODS: In a retrospective study performed in 24 German and Austrian hospitals and doctor's offices, patient and tumour characteristics of patients diagnosed with aSCC between January 1, 2010 and December 31, 2011 and their disease course was documented...
June 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29650272/treatment-of-spinal-metastases-in-renal-cell-carcinoma-a-critical-review
#6
REVIEW
Diego Teyssonneau, Marine Gross-Goupil, Charlotte Domblides, Thibaud Haaser, Vincent Pointillart, Amaury Daste, Olivier Hauger, Alain Ravaud
Kidney cancer is the 9th most common cancer in men and the 14th most common in women worldwide. Renal cell carcinoma (RCC) constitutes 90% of all malignancies of the kidney. RCC, is known to be highly vascular and relatively radioresistant. Bone metastases are one of the most common metastatic sites and occur in around 30% of RCCs. They significantly impact the quality of life of patients causing pain and pathological fractures. Spinal metastases represent a particular case with regard to symptoms and treatment...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29419331/-icorg-05-03-prospective-randomized-non-inferiority-phase-iii-trial-comparing-two-radiation-schedules-in-malignant-spinal-cord-compression-not-proceeding-with-surgical-decompression-the-quality-of-life-analysis
#7
K A Lee, M Dunne, C Small, P J Kelly, O McArdle, J O'Sullivan, D Hacking, M Pomeroy, J Armstrong, M Moriarty, A Clayton-Lea, I Parker, C D Collins, P Thirion
BACKGROUND: The optimal primary external beam radiation therapy (EBRT) radiation schedule for malignant epidural spinal cord compression (MSCC) remains to be determined. The ICORG 05-03 trial assessed if a 10 Gy single fraction radiation schedule was not inferior to one with 20 Gray (Gy) in five daily fractions, in terms of functional motor outcome, for the treatment of MSCC in patients not proceeding with surgical decompression. This article reports on two of the secondary endpoints, Quality of life (QoL), assessed according to the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) version 3...
February 8, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29394319/the-polycomb-proteins-ring1b-and-ezh2-repress-the-tumoral-pro-inflammatory-function-in-metastasizing-primary-cutaneous-squamous-cell-carcinoma
#8
Eugenia Hernández-Ruiz, Agustí Toll, Irene García-Diez, Evelyn Andrades, Carla Ferrandiz-Pulido, Emili Masferrer, Mireia Yébenes, Ane Jaka, Javier Gimeno, Ramón Gimeno, Vicenç García-Patos, Ramón M Pujol, Inmaculada Hernández-Muñoz
Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy in humans and approximately 5% metastasize, usually to regional lymph nodes. Epigenetic regulation of gene expression may allow tumoral cells to acquire new functions in order to escape from the primary tumor. The aim of this study was to investigate the expression and function of proteins of the Polycomb family of epigenetic regulators in the metastatic process of cSCC. A higher expression of RING1B and EZH2 was detected by immunohistochemistry in a series of primary cSCC tumors that metastasized (MSCCs) when compared with non-metastasizing cSCCs (non-MSCCs)...
March 8, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29364350/bone-marrow-derived-mesenchymal-stromal-cells-msc-from-diabetic-and-nondiabetic-rats-have-similar-therapeutic-potentials
#9
Vitória Santório de São José, Gustavo Monnerat, Barbara Guerra, Bruno Dias Paredes, Tais Hanae Kasai-Brunswick, Antonio Carlos Campos de Carvalho, Emiliano Medei
BACKGROUND: Diabetes mellitus is a severe chronic disease leading to systemic complications, including cardiovascular dysfunction. Previous cell therapy studies have obtained promising results with the use bone marrow mesenchymal stromal cells derived from healthy animals (MSCc) in diabetes animal models. However, the ability of MSC derived from diabetic rats to improve functional cardiac parameters is still unknown. OBJECTIVES: To investigate whether bone-marrow-derived MSC from diabetic rats (MSCd) would contribute to recover metabolic and cardiac electrical properties in other diabetic rats...
December 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29361876/impact-of-admission-imaging-findings-on-neurological-outcomes-in-acute-cervical-traumatic-spinal-cord-injury
#10
H Francis Farhadi, Sunil Kukreja, Amy Minnema, Lohith Vatti, Meera Gopinath, Luciano Prevedello, Cheng Chen, Huiyun Xiang, Jan M Schwab
Variable and unpredictable spontaneous recovery can occur after acute cervical traumatic spinal cord injury (tSCI). Despite the critical clinical and interventional trial planning implications of this tSCI feature, baseline measures to predict neurologic recovery accurately are not well defined. In this study, we used data derived from 99 consecutive patients (78 male, 21 female) with acute cervical tSCIs to assess the sensitivity and specificity of various clinical and radiological factors in predicting recovery at one year after injury...
March 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29287117/metastatic-spinal-cord-compression-mscc-treated-with-palliative-decompression-surgical-timing-and-survival-rate
#11
Wan-Yu Lo, Shu-Hua Yang
BACKGROUND: Metastatic spinal cord compression (MSCC) treatment depends on life expectancies. Data regarding palliative decompression outcomes is scarce. We demonstrate that surgical timing has a significant impact on survival in MSCC patients treated with palliative decompression. METHODS: Eighty-nine consecutive MSCC patients at a tertiary referral medical center were enrolled between January 2012 and February 2016. Wide laminectomy was performed for tumors invading the vertebral body...
2017: PloS One
https://www.readbyqxmd.com/read/29230336/metastatic-spinal-cord-compression-secondary-to-liver-cancer
#12
Daniel Gams Massi, Japhari Nyassinde, Ngor Side Diagne, Ramy Abdennaji, Kamadore Toure, Moustapha Ndiaye, Amadou Gallo Diop, Mouhamadou Mansour Ndiaye
Metastatic spinal cord compression (MSCC) is a medical emergency that requires rapid diagnosis and treatment to reduce pain, to preserve neurological functioning, and to prolong survival. The diagnosis of liver cancer is often neglected in the differential diagnosis of MSCC. Treatment is usually palliative and evolution is often fatal. This is a case report of a 28-year-old patient living in Mauritania hospitalized in November 2014 at the neurology department of Fann national teaching hospital in Dakar, for the management of a chronic dorsal spinal cord compression...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29202720/high-precision-radiotherapy-of-motor-deficits-due-to-metastatic-spinal-cord-compression-pre-mode-a-multicenter-phase-2-study
#13
Dirk Rades, Jon Cacicedo, Antonio J Conde-Moreno, Claudia Doemer, Jürgen Dunst, Darejan Lomidze, Barbara Segedin, Denise Olbrich, Niels Henrik Holländer
BACKGROUND: For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are often significantly impaired, an overall treatment time of 1 week would be preferable if resulting in similar outcomes as longer programs. This may be achieved with 5 × 5 Gy in 1 week, since the biologically effective dose is similar to 10 × 3 Gy...
December 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29187488/predictive-factors-and-a-survival-score-for-patients-irradiated-for-metastatic-spinal-cord-compression-from-carcinoma-of-the-salivary-glands
#14
Dirk Rades, Amira Bajrovic, Tobias Bartscht
AIM: To our knowledge, this is the first study focusing on metastatic spinal cord compression (MSCC) from carcinoma of the salivary glands. PATIENTS AND METHODS: Nine patients receiving radiation alone were evaluated for improvement of motor deficits, post-radiation gait function and survival. RESULTS: Of nine characteristics (radiation program, age, sex, additional metastases to bone or to other organs, dynamic of motor deficits, pre-radiation gait function, number of vertebrae affected by MSCC, general condition), strong trends were found for associations between improved motor deficits and their dynamic (p=0...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29156895/survival-analysis-of-malignant-epidural-spinal-cord-compression-after-palliative-radiotherapy-using-tokuhashi-scoring-system-and-the-impact-of-systemic-therapy
#15
Wing Ho Mui, Tai Chung Lam, Frank Chi Sing Wong, Wing King Sze
BACKGROUND: Previous studies have shown similar clinical outcomes of both single and multi-fraction (Fr) radiation therapy among malignant epidural spinal cord compression (MSCC) patients with poor prognosis; whereas, patients expected to have longer survival may require long-course radiotherapy to prevent local failure. However, such a poor prognosis risk group has not yet been clearly identified for use in daily clinical practice. We examined if the known predictive Tokuhashi scoring system could be adapted in MSCC patients treated with palliative radiation therapy...
December 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29140834/prognostic-factors-in-patients-with-metastatic-spinal-cord-compression-secondary-to-melanoma-a-systematic-review
#16
Nicholas J Hadden, Jerome R D McIntosh, Samuel Jay, Paula J Whittaker
Melanoma is one of the most common primary tumours associated with metastatic spinal cord compression (MSCC). The aim of this review is to identify prognostic factors specifically for MSCC secondary to melanoma. A systematic search of literature was performed in MEDLINE, Embase and the Cochrane Library to identify studies reporting prognostic factors for patients with MSCC secondary to melanoma. Two studies, involving a total of 39 patients, fulfilled the inclusion criteria. The variables associated with increased survival were receiving postoperative radiotherapy, receiving chemotherapy, perioperative lactate dehydrogenase level less than or equal to 8...
February 2018: Melanoma Research
https://www.readbyqxmd.com/read/29057987/magnetic-resonance-imaging-features-of-dogs-with-incomplete-recovery-after-acute-severe-spinal-cord-injury
#17
Melissa J Lewis, Eli B Cohen, Natasha J Olby
STUDY DESIGN: Retrospective case series. OBJECTIVES: Describe the magnetic resonance imaging (MRI) features of dogs chronically impaired after severe spinal cord injury (SCI) and investigate associations between imaging variables and residual motor function. SETTING: United States of America. METHODS: Thoracolumbar MRI from dogs with incomplete recovery months to years after clinically complete (paralysis with loss of pain perception) thoracolumbar SCI were reviewed...
February 2018: Spinal Cord
https://www.readbyqxmd.com/read/29021669/is-there-a-correlation-between-the-spinal-instability-neoplastic-score-and-mechanical-pain-in-patients-with-metastatic-spinal-cord-compression-a-prospective-cohort-study
#18
Rodrigo Ac Cavalcante, Yvens B Fernandes, Romulo Al Marques, Vinícius G Santos, Edésio Martins, Vladimir A Zaccariotti, João B Arruda, Claúdio E Tatsui, Andrei F Joaquim
INTRODUCTION: The decision for selecting patients for surgical treatment of metastatic spinal cord compression (MSCC) is challenging even for experienced surgeons. Recently, the spinal instability neoplastic score (SINS) has been proposed to help surgeons in the evaluation of spinal stability in the setting of spinal metastases. This study aimed to evaluate the correlation between SINS and preoperative visual analog scale (VAS), as well as the pre- and post-operative association of the VAS and neurological function...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/28986702/a-revision-of-the-tokuhashi-revised-score-improves-the-prognostic-ability-in-patients-with-metastatic-spinal-cord-compression
#19
Søren Schmidt Morgen, Sidsel Fruergaard, Martin Gehrchen, Sebastian Bjørck, Svend Aage Engelholm, Benny Dahl
PURPOSE: The Tokuhashi revised score from 2005 (TR2005) is the most recommended prognostic scoring system in patients with metastatic spinal cord compression (MSCC). However, recent studies have questioned its prognostic ability and the need for a new revision has been proposed. We aimed to assess whether a revision of the TR2005 can improve the prognostic ability of the scoring system. METHODS: In 2011 and 2012, a total of 1143 consecutive patients admitted with MSCC were prospectively included in a 2011 and a 2012 cohort...
January 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28951180/impact-of-symptomatic-metastatic-spinal-cord-compression-on-survival-of-patients-with-non-small-cell-lung-cancer
#20
Gustavo Telles da Silva, Anke Bergmann, Luiz Claudio Santos Thuler
OBJECTIVES: Non-small-cell lung cancer (NSCLC) is one of the most common primary tumor sites among patients with metastatic spinal cord compression (MSCC). This disorder is related to neurologic dysfunction and can reduce the quality of life, but the association between MSCC and death is unclear. The aim of this study was to analyze the impact of the occurrence of symptomatic MSCC on overall survival of patients with NSCLC. METHODS: A cohort study was carried out involving 1112 patients with NSCLC who were enrolled between 2006 and 2014 in a single cancer center...
December 2017: World Neurosurgery
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