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https://www.readbyqxmd.com/read/29419331/-icorg-05-03-prospective-randomized-non-inferiority-phase-iii-trial-comparing-two-radiation-schedules-in-malignant-spinal-cord-compression-not-proceeding-with-surgical-decompression-the-quality-of-life-analysis
#1
K A Lee, M Dunne, C Small, P J Kelly, O McArdle, J O'Sullivan, D Hacking, M Pomeroy, J Armstrong, M Moriarty, A Clayton-Lea, I Parker, C D Collins, P Thirion
BACKGROUND: The optimal primary external beam radiation therapy (EBRT) radiation schedule for malignant epidural spinal cord compression (MSCC) remains to be determined. The ICORG 05-03 trial assessed if a 10 Gy single fraction radiation schedule was not inferior to one with 20 Gray (Gy) in five daily fractions, in terms of functional motor outcome, for the treatment of MSCC in patients not proceeding with surgical decompression. This article reports on two of the secondary endpoints, Quality of life (QoL), assessed according to the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) version 3...
February 8, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29394319/the-polycomb-proteins-ring1b-and-ezh2-repress-the-tumoral-proinflammatory-function-in-metastasizing-primary-cutaneous-squamous-cell-carcinoma
#2
Eugenia Hernández-Ruiz, Agustí Toll, Irene García-Diez, Evelyn Andrades, Carla Ferrandiz-Pulido, Emili Masferrer, Mireia Yébenes, Ane Jaka, Javier Gimeno, Ramón Gimeno, Vicenç García-Patos, Ramón M Pujol, Inmaculada Hernández-Muñoz
Cutaneous squamous cell carcinoma (cSCC) is the second most common malignancy in humans and approximately 5% metastasize, usually to regional lymph nodes. Epigenetic regulation of gene expression may allow tumoral cells to acquire new functions in order to escape from the primary tumor. The aim of this study was to investigate the expression and function of proteins of the Polycomb family of epigenetic regulators in the metastatic process of cSCC. A higher expression of RING1B and EZH2 was detected by immunohistochemistry in a series of primary cSCC tumors that metastasized (MSCC) when compared to non-metastasizing cSCC (non-MSCC)...
January 31, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29364350/bone-marrow-derived-mesenchymal-stromal-cells-msc-from-diabetic-and-nondiabetic-rats-have-similar-therapeutic-potentials
#3
Vitória Santório de São José, Gustavo Monnerat, Barbara Guerra, Bruno Dias Paredes, Tais Hanae Kasai-Brunswick, Antonio Carlos Campos de Carvalho, Emiliano Medei
BACKGROUND: Diabetes mellitus is a severe chronic disease leading to systemic complications, including cardiovascular dysfunction. Previous cell therapy studies have obtained promising results with the use bone marrow mesenchymal stromal cells derived from healthy animals (MSCc) in diabetes animal models. However, the ability of MSC derived from diabetic rats to improve functional cardiac parameters is still unknown. OBJECTIVES: To investigate whether bone-marrow-derived MSC from diabetic rats (MSCd) would contribute to recover metabolic and cardiac electrical properties in other diabetic rats...
December 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29361876/impact-of-admission-imaging-findings-on-neurological-outcomes-in-acute-cervical-traumatic-spinal-cord-injury
#4
H Francis Farhadi, Sunil Kukreja, Amy Janelle Minnema, Lohith Vatti, Meera Gopinath, Luciano Prevedello, Cheng Chen, Huiyun Xiang, Jan Schwab
Variable and unpredictable spontaneous recovery can occur following acute cervical traumatic spinal cord injury (tSCI). Despite the critical clinical and interventional trial planning implications of this tSCI feature, baseline measures to accurately predict neurologic recovery are not well defined. In this study, we used data derived from 99 consecutive patients (78 male, 21 female) with acute cervical tSCIs to assess the sensitivity and specificity of various clinical and radiologic factors in predicting recovery at one year after injury...
January 23, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29287117/metastatic-spinal-cord-compression-mscc-treated-with-palliative-decompression-surgical-timing-and-survival-rate
#5
Wan-Yu Lo, Shu-Hua Yang
BACKGROUND: Metastatic spinal cord compression (MSCC) treatment depends on life expectancies. Data regarding palliative decompression outcomes is scarce. We demonstrate that surgical timing has a significant impact on survival in MSCC patients treated with palliative decompression. METHODS: Eighty-nine consecutive MSCC patients at a tertiary referral medical center were enrolled between January 2012 and February 2016. Wide laminectomy was performed for tumors invading the vertebral body...
2017: PloS One
https://www.readbyqxmd.com/read/29230336/metastatic-spinal-cord-compression-secondary-to-liver-cancer
#6
Daniel Gams Massi, Japhari Nyassinde, Ngor Side Diagne, Ramy Abdennaji, Kamadore Toure, Moustapha Ndiaye, Amadou Gallo Diop, Mouhamadou Mansour Ndiaye
Metastatic spinal cord compression (MSCC) is a medical emergency that requires rapid diagnosis and treatment to reduce pain, to preserve neurological functioning, and to prolong survival. The diagnosis of liver cancer is often neglected in the differential diagnosis of MSCC. Treatment is usually palliative and evolution is often fatal. This is a case report of a 28-year-old patient living in Mauritania hospitalized in November 2014 at the neurology department of Fann national teaching hospital in Dakar, for the management of a chronic dorsal spinal cord compression...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29202720/high-precision-radiotherapy-of-motor-deficits-due-to-metastatic-spinal-cord-compression-pre-mode-a-multicenter-phase-2-study
#7
Dirk Rades, Jon Cacicedo, Antonio J Conde-Moreno, Claudia Doemer, Jürgen Dunst, Darejan Lomidze, Barbara Segedin, Denise Olbrich, Niels Henrik Holländer
BACKGROUND: For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are often significantly impaired, an overall treatment time of 1 week would be preferable if resulting in similar outcomes as longer programs. This may be achieved with 5 × 5 Gy in 1 week, since the biologically effective dose is similar to 10 × 3 Gy...
December 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29187488/predictive-factors-and-a-survival-score-for-patients-irradiated-for-metastatic-spinal-cord-compression-from-carcinoma-of-the-salivary-glands
#8
Dirk Rades, Amira Bajrovic, Tobias Bartscht
AIM: To our knowledge, this is the first study focusing on metastatic spinal cord compression (MSCC) from carcinoma of the salivary glands. PATIENTS AND METHODS: Nine patients receiving radiation alone were evaluated for improvement of motor deficits, post-radiation gait function and survival. RESULTS: Of nine characteristics (radiation program, age, sex, additional metastases to bone or to other organs, dynamic of motor deficits, pre-radiation gait function, number of vertebrae affected by MSCC, general condition), strong trends were found for associations between improved motor deficits and their dynamic (p=0...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29156895/survival-analysis-of-malignant-epidural-spinal-cord-compression-after-palliative-radiotherapy-using-tokuhashi-scoring-system-and-the-impact-of-systemic-therapy
#9
Wing Ho Mui, Tai Chung Lam, Frank Chi Sing Wong, Wing King Sze
BACKGROUND: Previous studies have shown similar clinical outcomes of both single and multi-fraction (Fr) radiation therapy among malignant epidural spinal cord compression (MSCC) patients with poor prognosis; whereas, patients expected to have longer survival may require long-course radiotherapy to prevent local failure. However, such a poor prognosis risk group has not yet been clearly identified for use in daily clinical practice. We examined if the known predictive Tokuhashi scoring system could be adapted in MSCC patients treated with palliative radiation therapy...
August 29, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29140834/prognostic-factors-in-patients-with-metastatic-spinal-cord-compression-secondary-to-melanoma-a-systematic-review
#10
Nicholas J Hadden, Jerome R D McIntosh, Samuel Jay, Paula J Whittaker
Melanoma is one of the most common primary tumours associated with metastatic spinal cord compression (MSCC). The aim of this review is to identify prognostic factors specifically for MSCC secondary to melanoma. A systematic search of literature was performed in MEDLINE, Embase and the Cochrane Library to identify studies reporting prognostic factors for patients with MSCC secondary to melanoma. Two studies, involving a total of 39 patients, fulfilled the inclusion criteria. The variables associated with increased survival were receiving postoperative radiotherapy, receiving chemotherapy, perioperative lactate dehydrogenase level less than or equal to 8...
November 14, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29057987/magnetic-resonance-imaging-features-of-dogs-with-incomplete-recovery-after-acute-severe-spinal-cord-injury
#11
Melissa J Lewis, Eli B Cohen, Natasha J Olby
STUDY DESIGN: Retrospective case series. OBJECTIVES: Describe the magnetic resonance imaging (MRI) features of dogs chronically impaired after severe spinal cord injury (SCI) and investigate associations between imaging variables and residual motor function. SETTING: United States of America. METHODS: Thoracolumbar MRI from dogs with incomplete recovery months to years after clinically complete (paralysis with loss of pain perception) thoracolumbar SCI were reviewed...
October 23, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29021669/is-there-a-correlation-between-the-spinal-instability-neoplastic-score-and-mechanical-pain-in-patients-with-metastatic-spinal-cord-compression-a-prospective-cohort-study
#12
Rodrigo Ac Cavalcante, Yvens B Fernandes, Romulo Al Marques, Vinícius G Santos, Edésio Martins, Vladimir A Zaccariotti, João B Arruda, Claúdio E Tatsui, Andrei F Joaquim
INTRODUCTION: The decision for selecting patients for surgical treatment of metastatic spinal cord compression (MSCC) is challenging even for experienced surgeons. Recently, the spinal instability neoplastic score (SINS) has been proposed to help surgeons in the evaluation of spinal stability in the setting of spinal metastases. This study aimed to evaluate the correlation between SINS and preoperative visual analog scale (VAS), as well as the pre- and post-operative association of the VAS and neurological function...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/28986702/a-revision-of-the-tokuhashi-revised-score-improves-the-prognostic-ability-in-patients-with-metastatic-spinal-cord-compression
#13
Søren Schmidt Morgen, Sidsel Fruergaard, Martin Gehrchen, Sebastian Bjørck, Svend Aage Engelholm, Benny Dahl
PURPOSE: The Tokuhashi revised score from 2005 (TR2005) is the most recommended prognostic scoring system in patients with metastatic spinal cord compression (MSCC). However, recent studies have questioned its prognostic ability and the need for a new revision has been proposed. We aimed to assess whether a revision of the TR2005 can improve the prognostic ability of the scoring system. METHODS: In 2011 and 2012, a total of 1143 consecutive patients admitted with MSCC were prospectively included in a 2011 and a 2012 cohort...
October 6, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28951180/impact-of-symptomatic-metastatic-spinal-cord-compression-on-survival-of-patients-with-non-small-cell-lung-cancer
#14
Gustavo Telles da Silva, Anke Bergmann, Luiz Claudio Santos Thuler
OBJECTIVES: Non-small cell lung cancer (NSCLC) is one of the most common primary tumor site among patients with metastatic spinal cord compression (MSCC). This disorder is related to neurological dysfunction and can reduce the quality of life, but the association between MSCC and death is unclear. The aim of this study was to analyse the impact of the occurrence of symptomatic MSCC on overall survival (OS) of patients with NSCLC. MATERIAL AND METHODS: A cohort study was carried out involving 1112 patients with NSCLC who were enrolled between 2006 and 2014 in a single cancer center...
September 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28711277/use-of-a-midstream-clean-catch-mobile-application-did-not-lower-urine-contamination-rates-in-an-emergency-department
#15
Mary S Jacob, Paige Kulie, Cameron Benedict, Alexander J Ordoobadi, Neal Sikka, Erika Steinmetz, Melissa L McCarthy
OBJECTIVES: Urine microscopy is a common test performed in emergency departments (EDs). Urine specimens can easily become contaminated by different factors, including the collection method. The midstream clean-catch (MSCC) collection technique is commonly used to reduce urine contamination. The urine culture contamination rate from specimens collected in our ED is 30%. We developed an instructional application (app) to show ED patients how to provide a MSCC urine sample. We hypothesized that ED patients who viewed our instructional app would have significantly lower urine contamination rates compared to patients who did not...
July 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28701500/assessing-structure-and-function-of-myelin-in-cervical-spondylotic-myelopathy-evidence-of-demyelination
#16
Hanwen Liu, Erin L MacMillian, Catherine R Jutzeler, Emil Ljungberg, Alex L MacKay, Shannon H Kolind, Burkhard Mädler, David K B Li, Marcel F Dvorak, Armin Curt, Cornelia Laule, John L K Kramer
PURPOSE: To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques. METHODS: Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole body magnetic resonance scanner. Myelin water fraction (MWF) was extracted for the dorsal columns and whole cord. SSEPs and MWF were also compared with conventional MRI outcomes, including T2 signal intensity, compression ratio, maximum spinal cord compression (MSCC), and maximum canal compromise (MCC)...
August 8, 2017: Neurology
https://www.readbyqxmd.com/read/28660111/corticosteroid-treatment-for-metastatic-spinal-cord-compression-a-review
#17
REVIEW
Gordon D Skeoch, Matthew K Tobin, Sajeel Khan, Andreas A Linninger, Ankit I Mehta
STUDY DESIGN: Narrative review. OBJECTIVE: Metastatic spinal cord compression (MSCC) is a very frequent complication among cancer patients. Presenting commonly as nocturnal back pain, MSCC typically progresses to lower extremity paresis, loss of ambulatory capabilities, and paraplegia. In addition to standard treatment modalities, corticosteroid administration has been utilized in preclinical and clinical settings as adjunctive therapy to reduce local spinal cord edema and improve clinical symptoms...
May 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28492105/metastatic-spinal-cord-compression-as-the-first-sign-of-malignancy
#18
Johan Wänman, Pawel Grabowski, Helena Nyström, Patrik Gustafsson, Anders Bergh, Anders Widmark, Sead Crnalic
Background and purpose - Metastatic spinal cord compression (MSCC) as the initial manifestation of malignancy (IMM) limits the time for diagnostic workup; most often, treatment is required before the final primary tumor diagnosis. We evaluated neurological outcome, complications, survival, and the manner of diagnosing the primary tumor in patients who were operated for MSCC as the IMM. Patients and methods - Records of 69 consecutive patients (51 men) who underwent surgery for MSCC as the IMM were reviewed...
August 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28490462/genome-wide-dna-methylation-analysis-reveals-gabbr2-as-a-novel-epigenetic-target-for-egfr-19-deletion-lung-adenocarcinoma-with-induction-erlotinib-treatment
#19
Xiaomin Niu, Fatao Liu, Yi Zhou, Zhen Zhou, Daizhan Zhou, Ting Wang, Ziming Li, Xiangyun Ye, Yongfeng Yu, Xiaoling Weng, Hong Zhang, Junyi Ye, Meilin Liao, Yun Liu, Zhiwei Chen, Shun Lu
Purpose: The past decade has witnessed the rapid development of personalized targeted therapies in lung cancer. It is still unclear whether epigenetic changes are involved in the response to tyrosine kinase inhibitor (TKI) treatment in epidermal growth factor receptor (EGFR)-mutated lung cancer.Experimental Design: Methyl-sensitive cut counting sequencing (MSCC) was applied to investigate the methylation changes in paired tissues before and after erlotinib treatment for 42 days with partial response (PR) from stage IIIa (N2) lung adenocarcinoma patients (N = 2) with EGFR 19 deletion...
September 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28437329/metastatic-spinal-cord-compression-and-steroid-treatment-a-systematic-review
#20
Abhishek Kumar, Michael H Weber, Ziya Gokaslan, Jean-Paul Wolinsky, Meic Schmidt, Laurence Rhines, Michael G Fehlings, Ilya Laufer, Daniel M Sciubba, Michelle J Clarke, Narayan Sundaresan, Jorrit-Jan Verlaan, Arjun Sahgal, Dean Chou, Charles G Fisher
STUDY DESIGN: Systematic review. OBJECTIVES: We conducted a systematic review of the literature to answer the following questions regarding the use of steroid therapy in metastatic spinal cord compression (MSCC): 1. In cases of MSCC, what is the effect of steroid administration before definitive radiotherapy or surgery on ambulatory status, bowel and bladder function and survival? 2. What steroid dosing regimens are associated with the best outcomes concerning neurological symptoms and complication prevention in cases of MSCC? SUMMARY OF BACKGROUND DATA: Currently, there is significant variation in the initial bolus dose, daily maintenance dose and duration of treatment when steroids are used as a bridge to definitive therapy for MSCC...
May 2017: Clinical Spine Surgery
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