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https://www.readbyqxmd.com/read/29156422/syndecan-1-in-mechanosensing-of-nanotopological-cues-in-engineered-materials
#1
Victoria Le, Jason Lee, Somali Chaterji, Adrianne Spencer, Yen-Liang Liu, Peter Kim, Hsin-Chih Yeh, Deok-Ho Kim, Aaron B Baker
The cells of the vascular system are highly sensitive to biophysical cues from their local cellular microenvironment. To engineer improved materials for vascular devices and delivery of cell therapies, a key challenge is to understand the mechanisms that cells use to sense biophysical cues from their environment. Syndecans are heparan sulfate proteoglycans (HSPGs) that consist of a protein core modified with heparan sulfate glycosaminoglycan chains. Due to their presence on the cell surface and their interaction with cytoskeletal and focal adhesion associated molecules, cell surface proteoglycans are well poised to serve as mechanosensors of the cellular microenvironment...
November 9, 2017: Biomaterials
https://www.readbyqxmd.com/read/29155311/glenoid-exposure-in-total-shoulder-arthroplasty
#2
REVIEW
L Nové-Josserand, P Clavert
Glenoid exposure is agreed to be a difficult step, but is also a key step in total shoulder arthroplasty, both anatomic and reverse. It conditions unhindered use of the ancillary instrumentation and thus correct glenoid component positioning. The main stages comprise arthrotomy, by opening the rotator cuff, humeral head cut, and inferior glenohumeral release, enabling shifting of the humerus and good exposure of the glenoid cavity. The two main approaches are deltopectoral and anterosuperior transdeltoid. Using the deltopectoral approach, arthrotomy is performed through the subscapularis muscle, by various techniques...
November 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29153707/the-influence-of-muscle-activation-on-impact-dynamics-during-lateral-falls-on-the-hip
#3
Daniel R Martel, Iris C Levine, Steven P Pretty, Andrew C Laing
Muscle activation has been demonstrated to influence impact dynamics during scenarios including running, automotive impacts, and head impacts. This study investigated the effects of targeted muscle activation magnitude on impact dynamics during low energy falls on the hip with human volunteers. Fifteen university-aged participants (eight females, seven males) underwent 12 lateral pelvis release trials. Half of the trials were muscle-'relaxed'; in the remaining 'contracted' trials participants isometrically contracted their gluteus medius to 20-30% of maximal voluntary contraction before the drop was initiated onto a force plate...
November 10, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29152744/hirano-s-cover-body-model-and-its-unique-laryngeal-postures-revisited
#4
Andrew M Vahabzadeh-Hagh, Zhaoyan Zhang, Dinesh K Chhetri
OBJECTIVES/HYPOTHESIS: In 1974, Minoru Hirano proposed his theory of voice production that is now known as the cover-body theory. He described the thyroarytenoid (TA) and cricothyroid (CT) muscles as the major determinants of vocal fold shape and stiffness, and theorized four typical laryngeal configurations resulting from unique TA/CT activations, with implications for the resulting voice quality. In this study, we directly observed the vocal fold medial surface shape under Hirano's unique TA/CT activation conditions to obtain a three-dimensional (3D) understanding of these laryngeal configurations during muscle activation...
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29148138/artificial-walking-technologies-to-improve-gait-in-cerebral-palsy-multichannel-neuromuscular-stimulation
#5
Jessica Rose, Katelyn Cahill-Rowley, Erin E Butler
Cerebral palsy (CP) is the most common childhood motor disability and often results in debilitating walking abnormalities, such as flexed-knee and stiff-knee gait. Current medical and surgical treatments are only partially effective in improving gait abnormalities and may cause significant muscle weakness. However, emerging artificial walking technologies, such as step-initiated, multichannel neuromuscular electrical stimulation (NMES), can substantially improve gait patterns and promote muscle strength in children with spastic CP...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29148051/mechanical-parameters-of-the-molecular-motor-myosin-ii-determined-in-permeabilised-fibres-from-slow-and-fast-skeletal-muscles-of-the-rabbit
#6
Valentina Percario, Simona Boncompagni, Feliciano Protasi, Irene Pertici, Francesca Pinzauti, Marco Caremani
The skeletal muscle exhibits large functional differences depending on the myosin heavy chain (MHC) isoform expressed in its molecular motor myosin II. The differences in the mechanical features of force generation by myosin isoforms are investigated in situ by using fast sarcomere-level mechanical methods in permeabilised fibres (sarcomere length 2.4 μm, temperature 12°C, 4% dextran T-500) from the slow (soleus, containing the MHC-1 isoform) and the fast (psoas, containing the MHC-2X isoform) skeletal muscle of the rabbit...
November 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29146151/a-new-two-component-compression-system-turning-an-elastic-bandage-into-an-inelastic-compression-device-interface-pressure-stiffness-and-haemodynamic-effectiveness
#7
Giovanni Mosti, Hugo Partsch
INTRODUCTION: Bandage application does not exert consistent compression pressure, leading to extremely variable compression when applied to patients. A new elastic bandage can exert a predefined pressure independently of healthcare providers and the size of the wrapped limb. The bandage system includes a series of non-stretchable patches that when applied to the bandage make it stiff. The aim of this work was to assess, in an experimental setting, the venous ejection fraction (EF) from the lower leg and the tolerability of this new bandage in a group of patients affected by superficial venous incompetence...
November 13, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29145245/case-reports-about-an-overlooked-cause-of-neck-pain-calcific-tendinitis-of-the-longus-colli-case-reports
#8
Yeong-Jin Kim, Jae-Young Park, Ki-Young Choi, Bong-Ju Moon, Jung-Kil Lee
STUDY DESIGN: Case description. OBJECTIVE: Acute calcific tendinitis of the longus colli muscle is a rare clinical entity that causes severe neck pain. This entity is not well recognized due to its nonspecific presentation such as acute neck pain, neck stiffness, and odynophagia. The importance of this disease with a review of the literature is presented. SUMMARY OF BACKGROUND DATA: Acute calcific tendinitis of the longus colli muscle is an inflammatory condition caused by deposition of calcium hydroxyapatite in the superior oblique tendon fibers of the longus colli muscle...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143384/enhanced-ventricular-arterial-coupling-during-a-2-year-physical-activity-program-in-patients-with-rheumatoid-arthritis
#9
Philip Sarajlic, Cecilia Fridén, Lars H Lund, Aristomenis Manouras, Ashwin Venkateshvaran, Susanna C Larsson, Birgitta Nordgren, Christina H Opava, Ingrid E Lundberg, Magnus Bäck
OBJECTIVE: To establish how guided physical activity in patients with rheumatoid arthritis (RA) without known cardiovascular disease affected vascular and cardiac function, and how these two entities were prospectively interconnected in this patient group. METHODS: Prospective substudy of 29 participants in the Physical Activity in RA (PARA) 2010 trial. All subjects were examined at baseline, at year 1 and 2 with measures of pulse wave velocity and arterial augmentation index, as well as echocardiographic evaluation of diastolic parameters and ventricular-arterial coupling...
November 15, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29143379/region-dependent-hamstrings-activity-in-nordic-hamstring-exercise-and-stiff-leg-deadlift-defined-with-high-density-emg
#10
András Hegyi, Annamária Péter, Taija Finni, Neil J Cronin
Recent studies suggest region-specific metabolic activity in hamstring muscles during injury prevention exercises, but the neural representation of this phenomenon is unknown. The aim of this study was to examine whether regional differences are evident in the activity of biceps femoris long head (BFlh) and semitendinosus (ST) muscles during two common injury prevention exercises. Twelve male participants without a history of hamstring injury performed the Nordic hamstring exercise (NHE) and stiff-leg deadlift (SDL) while BFlh and ST activity were recorded with high-density electromyography (HD-EMG)...
November 15, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29139316/association-of-gastrocnemius-muscle-stiffness-with-passive-ankle-joint-stiffness-and-sex-related-difference-in-the-joint-stiffness
#11
Kintaro Chino, Hideyuki Takashi
Passive ankle joint stiffness is affected by all structures located within and over the joint, and is greater in men than in women. Localized muscle stiffness can be assessed by ultrasound shear wave elastography, and muscle architecture such as fascicle length and pennation angle can be measured by B-mode ultrasonography. Thus, we assessed localized muscle stiffness of the medial gastrocnemius (MG) with consideration of individual variability in the muscle architecture, and examined the association of the muscle stiffness with passive ankle joint stiffness and the sex-related difference in the joint stiffness...
November 15, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/29136538/the-impact-of-core-muscles-training-on-the-range-of-anterior-pelvic-tilt-in-subjects-with-increased-stiffness-of-the-hamstrings
#12
Michał Tomasz Kuszewski, Rafał Gnat, Anna Gogola
The aim of this study is to verify the hypotheses that muscular coordination training of the core region in subjects showing increased hamstring stiffness results in an increase in anterior pelvic tilt and that there is a correlation between hamstring stiffness and anterior pelvic tilt. The two-group, non-blinded experimental controlled trial with three repeated measurements of the dependent variables. The experimental group received muscular coordination training during a period of two weeks, control group - no training...
November 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29135646/foot-structure-and-function-in-habitually-barefoot-and-shod-adolescents-in-kenya
#13
Herje Aibast, Paul Okutoyi, Timothy Sigei, Walter Adero, Danny Chemjor, Neford Ongaro, Noriyuki Fuku, Kenn Konstabel, Carol Clark, Daniel E Lieberman, Yannis Pitsiladis
Habitually barefoot (HB) children from the Kalenjin tribe of Kenya are known for their high physical activity levels. To date, there has been no comprehensive assessment of foot structure and function in these highly active and HB children/adolescents and link with overuse injuries. PURPOSE: The aim of this research is to assess foot structure, foot function, injury and physical activity levels in Kenyan children and adolescents who are HB compared with those who were habitually shod (HS)...
November 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29131758/titin-gene-and-protein-functions-in-passive-and-active-muscle
#14
Wolfgang A Linke
The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider of passive tension and elasticity in myocytes. This review summarizes recent insight into the mechanisms behind how titin gene mutations cause hereditary cardiomyopathy and how titin protein is mechanically active in skeletal and cardiac myocytes. A main theme is the evolving role of titin as a modulator of contraction. Topics include strain-sensing via titin in the sarcomeric A-band as the basis for length-dependent activation, titin elastic recoil and refolding of titin domains as an energy source, and Ca(2+)-dependent stiffening of titin stretched during eccentric muscle contractions...
November 13, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/29131657/variability-of-the-dynamic-stiffness-of-foot-joints-effect-of-gait-velocity-variation
#15
Enrique Sanchis, Joaquín Luis Sancho-Bru, Alba Roda-Sales, Javier Pascual Huerta
BACKGROUND: Comparison of dynamic stiffness of foot joints was previously proposed to investigate pathological situations with changes in the properties of muscle and passive structures. Samples must be controlled to reduce the variability within groups being compared, which may arise from different sources, such as gait speed or foot posture index (FPI). METHODS: In this work, variability in the measurement of the dynamic stiffness of ankle, midtarsal and metatarsophalangeal joints was studied in a controlled sample of healthy adult male subjects with normal FPI, and the effect of gait speed was analyzed...
November 13, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29118111/differential-cell-matrix-mechanoadaptations-and-inflammation-drive-regional-propensities-to-aortic-fibrosis-aneurysm-or-dissection-in-hypertension
#16
M R Bersi, R Khosravi, A J Wujciak, D G Harrison, J D Humphrey
The embryonic lineage of intramural cells, microstructural organization of the extracellular matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of the aorta. Yet, it remains unclear why certain diseases manifest differentially along the aorta. Toward this end, myriad animal models provide insight into diverse disease conditions-including fibrosis, aneurysm and dissection-but inherent differences across models impede general interpretations. We examined region-specific cellular, matrix, and biomechanical changes in a single experimental model of hypertension and atherosclerosis, which commonly coexist...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29105276/quadriceps-muscle-fat-infiltration-is-associated-with-cardiometabolic-risk-in-copd
#17
Isabelle Vivodtzev, Luc Moncharmont, Renaud Tamisier, Jean-Christian Borel, François Arbib, Bernard Wuyam, Patrick Lévy, François Maltais, Gilbert Ferretti, Jean-Louis Pépin
PURPOSE: Losses of peripheral muscle mass and ectopic fat accumulation have been associated with cardiometabolic morbidity in COPD. We aimed at identifying the relationship between quadriceps muscle fat infiltration and cardiovascular risk. MATERIALS AND METHODS: From 2009 to 2014, 78 COPD patients (64 ± 8 years; 80% male) were prospectively included after having given written consent (ethical committee approval number: 2006-A00491-50). The cohort was divided into three groups (tertiles) according to body mass index (BMI), low [15 < BMI≤23·3], middle [23·3 < BMI≤27·6] and high [27·6 < BMI≤36] kg/m²)...
November 3, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29103836/assessing-the-viscoelastic-properties-of-upper-trapezius-muscle-intra-and-inter-tester-reliability-and-the-effect-of-shoulder-elevation
#18
C L Liu, Y N Feng, H Q Zhang, Y P Li, Y Zhu, Z J Zhang
BACKGROUND: Increasing stiffness in the upper trapezius muscle may contribute to imbalance of scapular motion, and result in shoulder and neck discomfort during shoulder flexion. Therefore, it is essential to quantify upper trapezius stiffness in various shoulder positions in order to aid in the prevention of these disorders and to optimize rehabilitation. OBJECTIVES: The objectives of the present study were to examine the intra and inter-tester reliability of MyotonPRO device in measuring upper trapezius stiffness and its ability to determine changes in stiffness during shoulder flexion...
October 19, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29100187/mechanical-muscle-and-tendon-properties-of-the-plantar-flexors-are-altered-even-in-highly-functional-children-with-spastic-cerebral-palsy
#19
Annika Kruse, Christian Schranz, Martin Svehlik, Markus Tilp
BACKGROUND: Recent ultrasound studies found increased passive muscle stiffness and no difference in tendon stiffness in highly impaired children and young adults with cerebral palsy. However, it is not known if muscle and tendon mechanical properties are already altered in highly functional children with cerebral palsy. Therefore, the purpose of this study was to compare the mechanical and material properties of the plantar flexors in highly functional children with cerebral palsy and typically developing children...
October 28, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29098620/clinical-evidence-of-exercise-benefits-for-stroke
#20
Peipei Han, Wen Zhang, Li Kang, Yixuan Ma, Liyuan Fu, Liye Jia, Hairui Yu, Xiaoyu Chen, Lin Hou, Lu Wang, Xing Yu, Masahiro Kohzuki, Qi Guo
Even though stroke is the third, not the first, most common cause of disability-adjusted life years in developed countries, it is one of the most expensive to treat. Part of the expense is due to secondary problems in the post-stroke period including: cognition, memory, attention span, pain, sensation loss, psychological issues, and problems with mobility and balance. Research has identified that exercise has both positive physical and psychosocial effects for post-stroke patients. Therefore, this scientific statement provides an overview on exercise rehabilitation for post-stroke patients...
2017: Advances in Experimental Medicine and Biology
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