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https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#1
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777242/malaria-in-2018-looking-to-the-past-and-moving-into-the-future
#2
EDITORIAL
Po Ying Chia, Li Yang Hsu, Tsin Wen Yeo
No abstract text is available yet for this article.
April 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29776448/anti-plasmodial-activities-of-combretum-molle-combretaceae-zwoo-seed-extract-in-swiss-albino-mice
#3
Merkin Anato, Tsige Ketema
OBJECTIVE: Objective of the study was to evaluate in vivo anti-plasmodial activities of Combretum molle seed extract. METHODS: As a standard protocol, initially the acute toxicity of the plant seed extract was checked following single administration of crude seed extract of the plant at doses 500, 1000 and 2000 mg/kg. This was followed by evaluation of anti-plasmodial activity of crude seed extract of the plant following a 4 days suppressive test. RESULTS: In acute toxicity study sign of toxicity was not observed...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29776379/development-of-a-rapid-field-applicable-molecular-diagnostic-for-knockdown-resistance-kdr-markers-in-an-gambiae
#4
Vera T Unwin, Shaun Ainsworth, Emily J Rippon, El Hadji Amadou Niang, Mark J I Paine, David Weetman, Emily R Adams
BACKGROUND: The spread of insecticide resistance (IR) is a major threat to vector control programmes for mosquito-borne diseases. Early detection of IR using diagnostic markers could help inform these programmes, especially in remote locations where gathering reliable bioassay data is challenging. Most current molecular tests for genetic IR markers are only suitable for use in well-equipped laboratory settings. There is an unmet need for field-applicable diagnostics. METHODS: A single-cartridge test was designed to detect key IR mutations in the major African vector of malaria, Anopheles gambiae...
May 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29776369/prevention-and-treatment-of-malaria-in-pregnancy-what-do-pregnant-women-and-health-care-workers-in-east-india-know-and-do-about-it
#5
Lora Sabin, Evan M S Hecht, Mohamad I Brooks, Mrigendra P Singh, Kojo Yeboah-Antwi, Abanish Rizal, Blair J Wylie, Philip A Bondzie, Matthew Banos, Jordan Tuchman, Neeru Singh, Davidson H Hamer
BACKGROUND: Limited qualitative research has been performed in India to investigate views and behaviours of pregnant women regarding malaria despite the threat of malaria-related adverse maternal and neonatal outcomes. To address this gap, a comprehensive study on malaria prevention and treatment attitudes, knowledge and behaviour among pregnant women in India was conducted. METHODS: Pregnant women and healthcare workers (HCWs), encompassing clinic-based providers, traditional birth attendants, and auxiliary nurse-midwives were enrolled for in-depth interviews (IDIs) at 7 hospital sites and nearby communities in Jharkhand and Chhattisgarh States...
May 18, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29776367/malaria-determining-risk-factors-at-the-household-level-in-two-rural-villages-of-mainland-equatorial-guinea
#6
Mónica Guerra, Bruno de Sousa, Nicolas Ndong-Mabale, Pedro Berzosa, Ana Paula Arez
BACKGROUND: After the introduction of an artemisinin-based combination therapy, the reduction of prevalence of malaria infections has shown a remarkable progress during the last decade. However due to the lack of a consistent malaria control programme and socioeconomic inequalities, Plasmodium infection is still one of the major cause of disease in Equatorial Guinea, namely in the rural communities. This study explored the associated risk factors of malaria transmission at the microeconomic level (households) in two rural villages of mainland Equatorial Guinea...
May 18, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29776361/emergence-of-knock-down-resistance-in-the-anopheles-gambiae-complex-in-the-upper-river-region-the-gambia-and-its-relationship-with-malaria-infection-in-children
#7
Anne L Wilson, Margaret Pinder, John Bradley, Martin J Donnelly, Majidah Hamid-Adiamoh, Lamin B S Jarju, Musa Jawara, David Jeffries, Ballah Kandeh, Emily J Rippon, Kolawole Salami, Umberto D'Alessandro, Steven W Lindsay
BACKGROUND: Insecticide resistance threatens malaria control in sub-Saharan Africa. Knockdown resistance to pyrethroids and organochlorines in Anopheles gambiae sensu lato (s.l.) is commonly caused by mutations in the gene encoding a voltage-gated sodium channel which is the target site for the insecticide. The study aimed to examine risk factors for knockdown resistance in An. gambiae s.l. and its relationship with malaria infection in children in rural Gambia. Point mutations at the Vgsc-1014 locus, were measured in An...
May 18, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29776359/evaluation-of-malaria-rapid-diagnostic-test-rdt-use-by-community-health-workers-a-longitudinal-study-in-western-kenya
#8
Matthew R Boyce, Diana Menya, Elizabeth L Turner, Jeremiah Laktabai, Wendy Prudhomme-O'Meara
BACKGROUND: Malaria rapid diagnostic tests (RDTs) are a simple, point-of-care technology that can improve the diagnosis and subsequent treatment of malaria. They are an increasingly common diagnostic tool, but concerns remain about their use by community health workers (CHWs). These concerns regard the long-term trends relating to infection prevention measures, the interpretation of test results and adherence to treatment protocols. This study assessed whether CHWs maintained their competency at conducting RDTs over a 12-month timeframe, and if this competency varied with specific CHW characteristics...
May 18, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29776357/anopheles-arabiensis-in-sudan-a-noticeable-tolerance-to-urban-polluted-larval-habitats-associated-with-resistance-to-temephos
#9
Rasha S Azrag, Babiker H Mohammed
BACKGROUND: It has been documented that unplanned urbanization leads to the exposure of members of the Anopheles vectors to a range of water pollution in urban settings. Many surveys from African and Asian countries reported the presence of Anopheles larvae in polluted urban habitats. The present study documents an obvious tolerance of the melanic and normal forms of Anopheles arabiensis to urban polluted larval habitats accompanied by resistance to Temephos larvicide. METHODS: A cross-sectional survey was carried out to inspect apparently polluted An...
May 18, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29775852/biomimetic-magnetoelectric-nanocrystals-synthesized-by-polymerization-of-heme-as-advanced-nanomaterials-for-biosensing-application
#10
Jeong Eun Hyeon, Da Woon Jeong, Young Jin Ko, Seung Wook Kim, Chulhwan Park, Sung Ok Han
Regardless of the malaria disease risk, the malaria parasite Plasmodium falciparum has an interesting mechanism. During its growth within the red blood cell, toxic free heme is converted into an insoluble crystalline form called the malaria pigment, or hemozoin. In particular, natural hemozoin nanocrystals can provide multiple applications in biosensing fields for health care and diagnosis as similar to artificial metal nanoparticles. In this study, the heme was biologically synthesized and polymerized by Corynebacterium glutamicum and final polymer was applied as a biomimetic conductive biopolymer...
May 10, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29775797/functional-screening-of-selective-mitochondrial-inhibitors-of-plasmodium
#11
Maria G Gomez-Lorenzo, Ane Rodríguez-Alejandre, Sonia Moliner-Cubel, María Martínez-Hoyos, Noemí Bahamontes-Rosa, Rubén Gonzalez Del Rio, Carolina Ródenas, Jesús de la Fuente, Jose Luis Lavandera, Jose F García-Bustos, Alfonso Mendoza-Losana
Phenotypic screening has produced most of the new chemical entities currently in clinical development for malaria, plus many lead compounds active against Plasmodium falciparum asexual stages. However, lack of knowledge about the mode of action of these compounds delays and may even hamper their future development. Identifying the mode of action of the inhibitors greatly helps to prioritise compounds for further development as novel antimalarials. Here we describe a whole-cell method to detect inhibitors of the mitochondrial electron transport chain, using oxygen consumption as high throughput readout in 384-well plate format...
May 9, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29775485/plasmodium-parasite-exploits-host-aquaporin-3-during-liver-stage-malaria-infection
#12
Dora Posfai, Kayla Sylvester, Anupama Reddy, Jack G Ganley, Johannes Wirth, Quinlan E Cullen, Tushar Dave, Nobutaka Kato, Sandeep S Dave, Emily R Derbyshire
Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are upregulated upon Plasmodium berghei infection of hepatocytes with the hypothesis that host pathways are hijacked to benefit parasite development. We found that expression of aquaporin-3 (AQP3), a water and glycerol channel, is significantly induced in Plasmodium-infected hepatocytes compared to uninfected cells. This aquaglyceroporin localizes to the parasitophorous vacuole membrane, the compartmental interface between the host and pathogen, with a temporal pattern that correlates with the parasite's expansion in the liver...
May 18, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29774292/evaluation-of-phytosynthesised-silver-nanoparticles-from-leaf-extracts-of-leucas-aspera-and-hyptis-suaveolens-and-their-larvicidal-activity-against-malaria-dengue-and-filariasis-vectors
#13
Devan Elumalai, Maduraiveeran Hemavathi, Chandrasekar Vijayalakshmi Deepaa, Patheri Kunyil Kaleena
The present study deals with the green synthesis of silver nanoparticle from the aqueous leaf extracts of Leucas aspera and Hyptis suaveolens as reducing agent and to investigate the larvicidal activity of synthesized silver nanoparticles. The synthesized silver nanoparticles were characterized by Ultraviolet and visible absorption spectroscopy (UV), Fourier transform-infrared spectroscopy (FT-IR), X-ray spectroscopy (XRD), Field emission scanning electron microscope (FESEM) and High-resonance transmission electron microscopy (HRTEM) analysis...
November 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774291/significant-decline-in-lymphatic-filariasis-associated-with-nationwide-scale-up-of-insecticide-treated-nets-in-zambia
#14
M Nsakashalo-Senkwe, E Mwase, E Chizema-Kawesha, V Mukonka, P Songolo, F Masaninga, M P Rebollo, B Thomas, M J Bockarie, H Betts, J R Stothard, L A Kelly-Hope
Lymphatic filariasis (LF) is a mosquito-borne disease, broadly endemic in Zambia, and is targeted for elimination by mass drug administration (MDA) of albendazole and diethylcarbamazine citrate (DEC) to at-risk populations. Anopheline mosquitoes are primary vectors of LF in Africa, and it is possible that the significant scale-up of malaria vector control over the past decade may have also impacted LF transmission, and contributed to a decrease in prevalence in Zambia. We therefore aimed to examine the putative association between decreasing LF prevalence and increasing coverage of insecticide-treated mosquito nets (ITNs) for malaria vector control, by comparing LF mapping data collected between 2003-2005 and 2009-2011 to LF sentinel site prevalence data collected between 2012 and 2014, before any anti-LF MDA was started...
November 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774286/biological-control-of-anopheles-darlingi-aedes-aegypti-and-culex-quinquefasciatus-larvae-using-shrimps
#15
Willian Marinho Dourado Coelho, Juliana de Carvalho Apolinário Coêlho, Katia Denise Saraiva Bresciani, Wilma Aparecida Starke Buzetti
Mosquitoes can act as vectors of important diseases such as malaria, dengue, Zika virus, yellow fever, Chikungunya and Mayaro fever, in addition to filariasis. The use of insecticides, larvicides, bed nets and repellents, besides the use of drugs as chemoprevention and the treatment of the sick are currently the pillars of the control of these vectors. We studied the biological control against of Anopheles darlingi , Aedes aegypti and Culex quinquefasciatus larvae using shrimps of the species M. pantanalense , M...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774074/placenta-specific-drug-delivery-by-trophoblast-targeted-nanoparticles-in-mice
#16
Baozhen Zhang, Lunbo Tan, Yan Yu, Baobei Wang, Zhilong Chen, Jinyu Han, Mengxia Li, Jie Chen, Tianxia Xiao, Balamurali K Ambati, Lintao Cai, Qing Yang, Nihar R Nayak, Jian Zhang, Xiujun Fan
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum- infected erythrocytes (IEs) accumulate in the placenta by adhering to chondroitin sulfate A (CSA) on the surfaces of trophoblasts. Based on this principle, we have developed a method for targeted delivery of payloads to the placenta using a synthetic placental CSA-binding peptide (plCSA-BP) derived from VAR2CSA, a CSA-binding protein expressed on IEs...
2018: Theranostics
https://www.readbyqxmd.com/read/29773818/predicting-transmission-blocking-potential-of-anti-malarial-compounds-in-the-mosquito-feeding-assay-using-plasmodium-falciparum-male-gamete-inhibition-assay
#17
Gonzalo Colmenarejo, Sonia Lozano, Carolina González-Cortés, David Calvo, Juliana Sanchez-Garcia, Jesús-Luís Presa Matilla, Didier Leroy, Janneth Rodrigues
Plasmodium falciparum Standard Membrane Feeding Assay (PfSMFA) is the current gold standard mosquito based confirmatory transmission blocking (TrB) assay for human malaria. However, owing to its complexity only selected gametocytocidal molecules are progressed into SMFA. Predictive tools for evaluation of TrB behavior of compounds in SMFA would be extremely beneficial, but lack of substantially large data sets from many mosquito feeds preempts the ability to perform correlations between outcomes from in vitro assays and SMFA...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773132/leishmania-in-wolves-in-northern-spain-a-spreading-zoonosis-evidenced-by-wildlife-sanitary-surveillance
#18
Alvaro Oleaga, Stefania Zanet, Alberto Espí, Marcia Raquel Pegoraro de Macedo, Christian Gortázar, Ezio Ferroglio
Leishmaniosis is, to date, considered the second most important emerging vector-borne protozoal disease in the world after malaria. The form of zoonotic visceral leishmaniosis found in the Mediterranean basin is caused by Leishmania infantum, and its life cycle includes the domestic dog and a phlebotomine sandfly vector. This complex epidemiological cycle and its high prevalence of subclinical infection, hinder the surveillance and control of L. infantum, and allows it to go unnoticed at the geographical endemicity limits of the parasite or in recently colonized areas...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772888/mapping-malaria-risk-using-geographic-information-systems-and-remote-sensing-the-case-of-bahir-dar-city-ethiopia
#19
Amare Sewnet Minale, Kalkidan Alemu
The main objective of this study was to develop a malaria risk map for Bahir Dar City, Amhara, which is situated south of Lake Tana on the Ethiopian plateau. Rainfall, temperature, altitude, slope and land use/land cover (LULC), as well as proximity measures to lake, river and health facilities, were investigated using remote sensing and geographical information systems. The LULC variable was derived from a 2012 SPOT satellite image by supervised classification, while 30-m spatial resolution measurements of altitude and slope came from the Shuttle Radar Topography Mission...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29772759/human-babesiosis-caused-by-babesia-duncani-has-widespread-distribution-across-canada
#20
John D Scott, Catherine M Scott
Human babesiosis caused by Babesia duncani is an emerging infectious disease in Canada. This malaria-like illness is brought about by a protozoan parasite infecting red blood cells. Currently, controversy surrounds which tick species are vectors of B. duncani. Since the availability of a serological or molecular test in Canada for B. duncani has been limited, we conducted a seven-year surveillance study (2011⁻2017) to ascertain the occurrence and geographic distribution of B. duncani infection country-wide...
May 17, 2018: Healthcare (Basel, Switzerland)
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