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Receptor for advanced glycation end products

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https://www.readbyqxmd.com/read/29778537/a-new-indanedione-derivative-alleviates-symptoms-of-diabetes-by-modulating-rage-nf-kappab-pathway-in-db-db-mice
#1
Gulnaz Khan, Meha Fatima Aftab, Bilquees Bano, Khalid Mohammed Khan, Munazza Murtaza, Sonia Siddiqui, M Hafizur Rehman, Rizwana Sanaullah Waraich
Accumulating evidence indicates that a number of tissues are damaged due to build-up of abnormal amount of Advanced Glycation End products (AGEs) in several diseases including diabetes. Currently AGE inhibitors are scarce in clinical use indicating a need for development of new anti-AGE agents. The aim of the current study is to identify the new AGE inhibitors and to decipher their mechanism of action for alleviating symptoms of diabetes in mice. Among several derivatives, one of the derivatives of indanedione, IDD-24 demonstrated highest inhibition of AGE formation and AGE mediated reactive oxygen species production in HepG-2 and mature 3T3-L1 adipocytes...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29774570/high-mobility-group-box-1-drives-fibrosis-progression-signaling-via-the-receptor-for-advanced-glycation-end-products-in-mice
#2
Xiaodong Ge, Elena Arriazu, Fernando Magdaleno, Daniel J Antoine, Rouchelle Dela Cruz, Neil Theise, Natalia Nieto
BACKGROUND & RATIONALE: High-mobility group box-1 (HMGB1) is a damage-associated molecular pattern (DAMP) increased in response to liver injury. Since HMGB1 is a ligand for the receptor for advanced glycation end-products (RAGE), we hypothesized that induction of HMGB1 could participate in the pathogenesis of liver fibrosis via RAGE cell-specific signaling mechanisms. RESULTS: liver HMGB1 protein expression correlated with fibrosis stage in patients with chronic Hepatitis C virus (HCV) infection, primary biliary cirrhosis (PBC) and alcoholic steatohepatitis (ASH)...
May 18, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29753380/chronic-alcohol-ingestion-impairs-rat-alveolar-macrophage-phagocytosis-via-disruption-of-rage-signaling
#3
Bashar S Staitieh, Eduardo E Egea, Xian Fan, Adaugo Amah, David M Guidot
BACKGROUND: Alcohol significantly impairs antioxidant defenses and innate immune function in the lung and increases matrix metalloproteinase 9 (MMP-9) activity. The receptor for advanced glycation end products (RAGE) is a well-characterized marker of lung injury that is cleaved by MMP-9 into soluble RAGE and has not yet been examined in the alcoholic lung. We hypothesized that chronic alcohol ingestion would impair RAGE signaling via MMP-9 in the alveolar macrophage and thereby impair innate immune function...
May 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29752466/mir-5591-5p-regulates-the-effect-of-adscs-in-repairing-diabetic-wound-via-targeting-ages-ager-jnk-signaling-axis
#4
Qiang Li, Sizhan Xia, Yating Yin, Yanping Guo, Feifei Chen, Peisheng Jin
Advanced glycation end products/advanced glycation end products receptor (AGEs/AGER) interaction triggers reactive oxygen species (ROS) generation and activates downstream signal pathways and induces apoptosis in endothelial progenitor cells. A number of studies have revealed the involvement of microRNAs (miRNAs) in regulating intracellular ROS production and apoptosis. However, few studies explore the role of miRNAs in regulating the effect of adipose tissue-derived stem cells (ADSCs) in repairing diabetic wound and the associated cellular mechanisms remain unclear...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29750887/the-effects-of-acute-hypoxia-on-tissue-oxygenation-and-circulating-alarmins-in-healthy-adults
#5
C J Boos, C M Lamb, M Midwinter, A Mellor, D R Woods, M Howley, T Stansfield, M Foster, J P O'hara
The binding of high-mobility group box-1 (HMGB-1) to the membrane receptor for advanced glycation end-products (mRAGE) is a key early mediator of non-infectious inflammation and its triggers include ischaemia/hypoxia. The effects of acute hypoxia on soluble RAGE (sRAGE) are unknown. Fourteen healthy adults (50% women; 26.6+/-3.8 years) were assessed at baseline normoxia (T0), followed by four time-points (T90, 95, 100 and 180 minutes) over three hours of continuous normobaric hypoxia (NH, 4450m equivalent) and again 60 minutes after return to normoxia (T240)...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29747745/the-potential-effect-of-garlic-extract-and-curcumin-nanoparticles-against-complication-accompanied-with-experimentally-induced-diabetes-in-rats
#6
Afaf D Abdel-Mageid, Mohamed E S Abou-Salem, Nancy M H A Salaam, Hoda A S El-Garhy
BACKGROUND: Modified herbal medicines implicate the combination of several therapeutic practices of native systems of medicine that may extend many earlier generations, which frequently afford valuable therapeutic benefits. PURPOSE: In this study, the role of nano-curcumin and aged garlic extract (AGE) as two modified phytomedicines on alleviating both of advanced glycation end products (AGEPs) and oxidative stress (OS) in streptozotocin (STZ) induced diabetic rats were investigated during this study...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29744367/age-rage-induced-emp-release-via-the-nox-derived-ros-pathway
#7
Ying-Hua Chen, Zhang-Wei Chen, Hong-Mei Li, Xin-Feng Yan, Bo Feng
Objective: Diabetes is associated with accelerated formation of advanced glycation end products (AGEs) that are extensively found in circulating endothelial microparticles (EMPs). This study aimed to investigate whether AGEs have a direct effect on EMP formation and the possible underlying mechanism. Methods: In vitro, cultured human umbilical vein endothelial cells (HUVECs) were incubated with AGEs (200 and 400  μ g/ml) for 24 hours with or without pretreatment with anti-RAGE antibody, NOX inhibitor, or ROS scavenger...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29737911/immunolocalization-of-advanced-glycation-end-products-mitogen-activated-protein-kinases-and-transforming-growth-factor-%C3%AE-smads-in-pelvic-organ-prolapse
#8
Antonella Vetuschi, Simona Pompili, Anna Gallone, Angela D'Alfonso, Maria Gabriella Carbone, Gaspare Carta, Claudio Festuccia, Eugenio Gaudio, Alessandro Colapietro, Roberta Sferra
Collagen and matrix metalloproteinases (MMP) play a pivotal role in the pathophysiology of Pelvic Organ Prolapse (POP) as a switch between type I and III collagen together with a simultaneous activation of MMPs have been observed in the vaginal wall. The aim of this study was to evaluate the Advanced Glycation End (AGE) products, ERK1/2 and transforming growth factor (TGF)-β/Smad pathway expression in muscularis propria in women with POP compared with control patients. We examined 20 patients with POP and 10 control patients treated for uterine fibromatosis...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29737246/role-of-ox-ldl-and-lox-1-in-atherogenesis
#9
Ajoe John Kattoor, Sri Harsha Kanuri, Jawahar L Mehta
Oxidized LDL (ox-LDL) plays a central role in atherosclerosis by acting on multiple cells such as endothelial cells, macrophages, platelets, fibroblasts and smooth muscle cells through LOX-1. LOX-1 is a 50 kDa transmembrane glycoprotein that serves as receptor for ox-LDL, modified lipoproteins, activated platelets and advance glycation end-products. Ox-LDL through LOX-1, in endothelial cells, cause increase in leukocyte adhesion molecules, activates pathways of apoptosis, increase reactive oxygen species and cause endothelial dysfunction...
May 7, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29723156/circulating-soluble-rage-and-cell-surface-rage-on-peripheral-blood-mononuclear-cells-in-healthy-children
#10
Alberto García-Salido, Gustavo Melen, Vanesa Gómez-Piña, Gonzalo Oñoro-Otero, Ana Serrano-González, Juan Casado-Flores, Manuel Ramírez
BACKGROUND: The receptor for advanced glycation end products (RAGE) has a critical role in the pathogenesis of inflammation. In healthy children, its basal expression on the peripheral blood mononuclear cell (PBMC) and the basal circulating soluble RAGE (sRAGE) levels are unknown. The aim of this study was to describe both. METHODS: This is a monocentric, observational and descriptive study of samples obtained from healthy children. The RAGE expression on PBMC was analyzed using flow cytometry...
May 3, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29702284/glycyrrhizin-ameliorates-atopic-dermatitis-like-symptoms-through-inhibition-of-hmgb1
#11
Ying Wang, Yue Zhang, Ge Peng, Xiuping Han
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease prevalent worldwide. This study investigated the effects of glycyrrhizin, an extract of licorice root, on the well-established model of 2,4-dinitrochlorobenzene-induced AD-like symptoms in mice. The severity of dermatitis, histopathological changes, serum IgE levels, changes in expression of high-mobility group box 1 (HMGB1), the receptor for advanced glycation end products (RAGE), nuclear factor (NF)-κB and inflammatory cytokines were evaluated...
April 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29693146/high-glucose-promotes-tumor-cell-proliferation-and-migration-in-lung-adenocarcinoma-via-the-rage%C3%A2-noxs-pathway
#12
Yuan-Fan Liao, Sui Yin, Zi-Qi Chen, Fan Li, Bo Zhao
Over the past few decades, it has been demonstrated that hyperglycemia can promote lung carcinoma growth, potentially through significantly increased glucose metabolism; however, the underlying mechanism remains to be fully elucidated. In the present study, treatment with a high concentration of glucose (HG) significantly promoted the proliferation and migration of A549 cells. Receptor for advanced glycation end‑products (RAGE) has previously been demonstrated to be associated with diabetes mellitus and oxidative stress, and nicotinamide adenine dinucleotide phosphate oxidases (NOXs) are considered to be initiating factors of oxidative stress...
April 23, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29681765/metabolic-derangements-contribute-to-reduced-srage-isoforms-in-subjects-with-alzheimer-s-disease
#13
Kelly N Z Fuller, Edwin R Miranda, John P Thyfault, Jill K Morris, Jacob M Haus
Although there is evidence for metabolic dysfunction and chronic inflammation in Alzheimer's disease (AD), circulating levels of soluble receptor for advanced glycation end products (sRAGE) and the receptor for advanced glycation end products (RAGE) ligand S100B have not been characterized. sRAGE is an important mediator in disease as it can act as a ligand decoy for RAGE and attenuate downstream inflammatory signaling. Cognitively healthy elderly and AD participants with and without type 2 diabetes ( n = 135) were stratified according to the clinical dementia rating (CDR; 0 = normal cognition (NC); ≥0...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29676511/role-of-the-high-mobility-group-box-1-signalling-axes-via-the-receptor-for-advanced-glycation-end-products-and-toll-like-receptor-4-in-the-immunopathology-of-oral-lichen-planus-a-potential-drug-target
#14
Abdelhakim Salem, Rabeia Almahmoudi, Mari Vehviläinen, Tuula Salo
High mobility group box 1 (HMGB1) is an extremely conserved DNA-binding protein that stabilizes nucleosomes and facilitates gene transcription in mammalian cells. When released extracellularly, HMGB1 becomes an alarmin that can mediate systemic diseases. High mobility group box 1 signals via two main receptors: receptor for advanced glycation end-products (RAGE) and toll-like receptor-4 (TLR4). We hypothesized that HMGB1 expression is increased in patients with oral lichen planus (OLP) relative to healthy controls...
April 20, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29670673/pm2-5-induced-the-expression-of-fibrogenic-mediators-via-hmgb1-rage-signaling-in-human-airway-epithelial-cells
#15
Weifeng Zou, Fang He, Sha Liu, Jinding Pu, Jinxing Hu, Qing Sheng, Tao Zhu, Tianhua Zhu, Bing Li, Pixin Ran
Background: The aim of the present study was to test whether fine particulate matter (PM2.5) induces the expression of platelet-derived growth factor-AB (PDGF-AB), PDGF-BB, and transforming growth factor- β 1 (TGF- β 1) in human bronchial epithelial cells (HBECs) in vitro via high-mobility group box 1 (HMGB1) receptor for advanced glycation end products (RAGE) signaling. Methods: Sprague-Dawley rats were exposed to motor vehicle exhaust (MVE) or clean air. HBECs were either transfected with a small interfering RNA (siRNA) targeting HMGB1 or incubated with anti-RAGE antibodies and subsequently stimulated with PM2...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29667227/effects-of-knockout-of-the-receptor-for-advanced-glycation-end-products-on-bone-mineral-density-and-synovitis-in-mice-with-intra-articular-fractures
#16
Dongrim Seol, Yuki Tochigi, Ashley M Bogner, Ino Song, Douglas C Fredericks, Gail L Kurriger, Sonja M Smith, Jessica E Goetz, Joseph A Buckwalter, James A Martin
Our group employed the mouse closed intra-articular fracture (IAF) model to test the hypothesis that the innate immune system plays a role in initiating synovitis and post-traumatic osteoarthritis (PTOA) in fractured joints. A transgenic strategy featuring knockout of the receptor for advanced glycation end-products (RAGE -/- ) was pursued. The 42 and 84 mJ impacts used to create fractures were in the range previously reported to cause PTOA at 60 days post-fracture. MicroCT (µCT) was used to assess fracture patterns and epiphyseal and metaphyseal bone loss at 30 and 60 days post-fracture...
April 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29660374/a-ternary-complex-of-a-suicide-gene-a-rage-binding-peptide-and-polyethylenimine-as-a-gene-delivery-system-with-anti-tumor-and-anti-angiogenic-dual-effects-in-glioblastoma
#17
Eunji Choi, Jungju Oh, Dahee Lee, Jaewon Lee, Xiaonan Tan, Minkyung Kim, Gyeungyun Kim, Chunxian Piao, Minhyung Lee
The receptor for advanced glycation end-products (RAGE) is involved in tumor angiogenesis. Inhibition of RAGE might be an effective anti-angiogenic therapy for cancer. In this study, a cationic RAGE-binding peptide (RBP) was produced as an antagonist of RAGE, and a ternary-complex consisting of RBP, polyethylenimine (2 kDa, PEI2k), and a suicide gene (pHSVtk) was developed as a gene delivery system with dual functions: the anti-tumor effect of pHSVtk and anti-angiogenic effect of RBP. As an antagonist of RAGE, RBP decreased the secretion of vascular-endothelial growth factor (VEGF) in activated macrophages and reduced the tube-formation of endothelial cells in vitro...
April 13, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29656209/phosphorylation-of-low-density-lipoprotein-receptor-related-protein-6-is-involved-in-receptor-for-advanced-glycation-end-product-mediated-%C3%AE-catenin-stabilization-in-a-toluene-diisocyanate-induced-asthma-model
#18
Jing Xiong, Wenqu Zhao, Yun Lin, Lihong Yao, Guohua Huang, Changhui Yu, Hangming Dong, Guanhua Xiao, Haijin Zhao, Shaoxi Cai
BACKGROUND: We have previously demonstrated that the receptor for advanced glycation end products (RAGE)/β-catenin axis plays a vital role in regulating airway inflammation and airway remodeling in a toluene diisocyanate (TDI)-induced murine asthma model. However, the exact mechanism of β-catenin activation remains unclear. Given that phosphorylation of the low-density lipoprotein receptor-related protein 6 (Lrp6) is a key step in mediating β-catenin stabilization in canonical wnt/β-catenin signaling, we explored the possible relationship between RAGE and Lrp6 in regulating β-catenin stabilization in TDI-induced asthma...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29651042/effects-of-scavenger-receptors-1-class-a-stimulation-on-macrophage-morphology-and-highly-modified-advanced-glycation-end-product-protein-phagocytosis
#19
Shinichi Hamasaki, Takuro Kobori, Yui Yamazaki, Atsuhiro Kitaura, Atsuko Niwa, Takashi Nishinaka, Masahiro Nishibori, Shuji Mori, Shinichi Nakao, Hideo Takahashi
Advanced glycation end-products (AGEs), which comprise non-enzymatically glycosylated proteins, lipids, and nucleic acid amino groups, play an important role in several diseases and aging processes including angiopathy, renal failure, diabetic complications, and neurodegenerative diseases. Among AGE-associated phenotypes, toxic AGEs, glyceraldehyde-derived AGE-2, and glycolaldehyde-derived AGE-3 are involved in the pathogenesis of diabetic complications. In addition, macrophages are reported to remove extracellular AGEs from tissues via scavenger receptors, leading to the progression of atherosclerosis...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29644926/role-of-ligands-of-receptor-for-advanced-glycation-end-products-rage-in-peripheral-artery-disease
#20
Sho-Ichi Yamagishi, Takanori Matsui
Atherosclerotic cardiovascular disease, including peripheral artery disease (PAD) is more common and severe in diabetic patients compared with non-diabetic individuals. Indeed, diabetes is associated with the increased risk of limb amputation and all-cause mortality in patients with symptomatic PAD. Proteins and lipids are non-enzymatically modified by sugars, resulting in the formation and accumulation of advanced glycation end products (AGEs), whose process is accelerated under diabetic conditions, especially patients with a long duration of diabetes...
April 12, 2018: Rejuvenation Research
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