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Receptor for advanced glycation end products

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https://www.readbyqxmd.com/read/29332040/synthetic-fragment-of-receptor-for-advanced-glycation-end-products-prevents-memory-loss-and-protects-brain-neurons-in-olfactory-bulbectomized-mice
#1
Olga M Volpina, Alexandr N Samokhin, Dmitriy O Koroev, Inna V Nesterova, Tatyana D Volkova, Natalia I Medvinskaya, Pavel V Nekrasov, Olga G Tatarnikova, Anna V Kamynina, Samson M Balasanyants, Tamara A Voronina, Alexey M Kulikov, Natalia V Bobkova
Activation of receptor for advanced glycation end products (RAGE) plays an essential role in the development of Alzheimer's disease (AD). It is known that the soluble isoform of the receptor binds to ligands and prevents negative effects of the receptor activation. We proposed that peptide fragments from RAGE prevent negative effects of the receptor activation during AD neurodegeneration. We have synthesized peptide fragments from surface-exposed regions of RAGE. Peptides were intranasally administrated into olfactory bulbectomized (OBX) mice, which developed some characteristics similar to AD neurodegeneration...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29329449/lack-of-receptor-for-advanced-glycation-end-products-leads-to-less-severe-staphylococcal-skin-infection-but-more-skin-abscesses-and-prolonged-wound-healing
#2
Manli Na, Majd Mohammad, Ying Fei, Wanzhong Wang, André Holdfeldt, Huamei Forsman, Abukar Ali, Rille Pullerits, Tao Jin
Background: Lack of Receptor for Advanced Glycation End products (RAGE) ameliorates several infections including Staphylococcus aureus (S. aureus) pneumonia. We sought to investigate the role of RAGE in staphylococcal skin infection in mice. Methods: Wild-type (WT) and RAGE deficient (RAGE-/-) mice were subcutaneously inoculated with S. aureus SH1000 strain in abscess forming dose or necrotic dose. Clinical signs of dermatitis, along with histopathological changes, were compared between the groups...
January 10, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29329433/rage-mediates-a%C3%AE-accumulation-in-a-mouse-model-of-alzheimer-s-disease-via-modulation-of-%C3%AE-and-%C3%AE-secretase-activity
#3
Fang Fang, Qing Yu, Ottavio Arancio, Doris Chen, Smruti S Gore, Shi Fang Yan, Shirley ShiDu Yan
Receptor for Advanced Glycation End products (RAGE) has been implicated in amyloid β-peptide (Aβ)-induced perturbation relevant to the pathogenesis of Alzheimer's disease (AD). However, whether and how RAGE regulates Aβ metabolism remains largely unknown. Aβ formation arises from aberrant cleavage of amyloid precursor protein (APP) by β- and γ-secretase. To investigate whether RAGE modulates β- and γ-secretase activity potentiating Aβ formation, we generated mAPP mice with genetic deletion of RAGE (mAPP/RO)...
January 10, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29318368/increased-levels-of-advanced-glycation-end-products-positively-correlate-with-iron-overload-and-oxidative-stress-markers-in-patients-with-%C3%AE-thalassemia-major
#4
Maryam Sadat Mirlohi, Hamid Yaghooti, Saeed Shirali, Ali Aminasnafi, Samaneh Olapour
The impaired biosynthesis of the β-globin chain in β-thalassemia leads to the accumulation of unpaired alpha globin chains, failure in hemoglobin formation, and iron overload due to frequent blood transfusion. Iron excess causes oxidative stress and massive tissue injuries. Advanced glycation end products (AGEs) are harmful agents, and their production accelerates in oxidative conditions. This study was conducted on 45 patients with major β-thalassemia who received frequent blood transfusions and chelation therapy and were compared to 40 healthy subjects...
January 9, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29317590/the-association-between-variants-of-receptor-for-advanced-glycation-end-products-rage-gene-polymorphisms-and-age-related-macular-degeneration
#5
Mantas Banevicius, Alvita Vilkeviciute, Loresa Kriauciuniene, Rasa Liutkeviciene, Vytenis Pranas Deltuva
BACKGROUND Age-related macular degeneration (AMD) is the leading cause of blindness in people aged 65 years and older in developed countries. The pathogenesis of AMD has been linked to mechanisms involving inflammation, oxidative stress, and basal laminar deposit formation between retinal pigment epithelium (RPE) cells and the basal membrane, caused by advanced glycation end products (AGEs). AGEs are implicated in the pathogenesis of AMD through the AGE-and receptor for AGE (RAGE) interaction, which can be altered by polymorphisms of the RAGE gene...
January 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29316860/receptor-for-advanced-glycation-end-products-rage-mediated-cytotoxicity-of-3-hydroxypyridinium-derivatives
#6
Yoto Murakami, Takayuki Fujino, Toshiki Hasegawa, Ryotaro Kurachi, Aya Miura, Takumi Daikoh, Teruyuki Usui, Fumitaka Hayase, Hirohito Watanabe
Advanced glycation end products (AGEs) formed from glyceraldehyde (Gcer) and glycolaldehyde (Gcol) are involved in the pathogenesis of diabetic complications, via interactions with a receptor for AGEs (RAGE). In this study, we aimed to elucidate the RAGE-binding structure in Gcer and Gcol-derived AGEs and identify the minimal moiety recognized by RAGE. Among Gcer and Gcol-derived AGEs, GLAP (glyceraldehyde-derived pyridinium) and GA-pyridine elicited toxicity in PC12 neuronal cells. The toxic effects of GLAP and GA-pyridine were suppressed in the presence of anti-RAGE antibody or the soluble form of RAGE protein...
January 10, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29309329/extracorporal-shock-wave-therapy-enhances-receptor-for-advanced-glycated-end-product-dependent-flap-survival-and-angiogenesis
#7
Emrullah Birgin, Christoffer Gebhardt, Svetlana Hetjens, Sebastian Fischer, Felix Rückert, Matthias A Reichenberger
BACKGROUND/OBJECTIVES: Loss of skin flaps due to deteriorated wound healing is a crucial clinical issue. Extracorporal shock wave therapy (ESWT) promotes flap healing by inducing angiogenesis and suppressing inflammation. The receptor for advanced glycation end-products (RAGEs) was identified to play a pivotal role in wound healing. However, to date, the role of RAGE in skin flaps and its interference with ESWT are unknown. METHODS: Caudally pedicled musculocutanous skin flaps in RAGE and wt mice were treated with low-dose extracorporal shock waves (s-RAGE, s-wt) and analyzed for flap survival, histomorphologic studies, and immunohistochemistry during a 10-day period...
January 5, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29301761/uremic-advanced-glycation-end-products-and-protein-bound-solutes-induce-endothelial-dysfunction-through-suppression-of-kr%C3%A3-ppel-like-factor-2
#8
Keith Saum, Begoña Campos, Diego Celdran-Bonafonte, Lalitha Nayak, Panjamaporn Sangwung, Charuhas Thakar, Prabir Roy-Chaudhury, A Phillip Owens
BACKGROUND: Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage renal disease. The accumulation of uremic solutes in this patient population is associated with endothelial dysfunction and accelerated cardiovascular disease. In this study, we examined the impact of the uremic milieu on the endothelial transcription factor, Krüppel-like factor 2 (KLF2), a key regulator of endothelial function and activation. METHODS AND RESULTS: Using serum from uremic pigs with chronic renal insufficiency, our results show that KLF2 expression is suppressed by the uremic milieu and individual uremic solutes in vitro...
January 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29298878/ager-promotes-proliferation-and-migration-in-cervical-cancer
#9
Xuejie Zhu, Lulu Zhou, Ruyi Li, Qi Shen, Huihui Cheng, Zongji Shen, Haiyan Zhu
Advanced Glycation End-products Specific receptor for (AGER) is an oncogenic trans-membranous receptor up-regulated in various human cancers. We have previously reported that AGER was over-expressed in squamous cervical cancer. However, mechanisms of AGER involved in progression of cervical cancer are unknown. In this study, we investigated the effects of AGER on biological behavior, including proliferation, apoptosis, and migration using multiple biological approaches. AGER protein primarily localized in the cytoplasm and cytomembrane of cervical squamous cancer cells...
January 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29285052/suppression-of-alzheimer-s-disease-related-phenotypes-by-the-heat-shock-protein-70-inducer-geranylgeranylacetone-in-app-ps1-transgenic-mice-via-the-erk-p38-mapk-signaling-pathway
#10
Yuan Sun, Jiang-Rong Zhang, Shuyan Chen
HSP70 overexpression has a remedying effect in neurodegenerative diseases. In Alzheimer's disease (AD), the suppressive effects of HSP70 overexpression on AD-related phenotypes and the underlying mechanisms are unknown. In the current study, the effect of geranylgeranylacetone (GGA), a non-toxic inducer of heat shock protein (HSP)-70 expression, on cognitive function and other pathological phenotypes were evaluated in APP/PS1 mice. It was observed that all doses of orally administered GGA (200, 400, and 800 mg/kg/day) improved cognitive deficit (P<0...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29283384/high-mobility-group-box-1-mediates-fibroblast-activity-via-rage-mapk-and-nf-%C3%AE%C2%BAb-signaling-in-keloid-scar-formation
#11
Jihee Kim, Jong-Chul Park, Mi Hee Lee, Chae Eun Yang, Ju Hee Lee, Won Jai Lee
Emerging studies have revealed the involvement of high-mobility group box 1 (HMGB1) in systemic fibrotic diseases, yet its role in the cutaneous scarring process has not yet been investigated. We hypothesized that HMGB1 may promote fibroblast activity to cause abnormal cutaneous scarring. In vitro wound healing assay with normal and keloid fibroblasts demonstrated that HMGB1 administration promoted the migration of both fibroblasts with increased speed and a greater traveling distance. Treatment of the HMGB1 inhibitor glycyrrhizic acid (GA) showed an opposing effect on both activities...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29282280/ligand-specific-binding-forces-of-lfa-1-and-mac-1-in-neutrophil-adhesion-and-crawling
#12
Ning Li, Hao Yang, Manliu Wang, Shouqin Lü, Yan Zhang, Mian Long
Lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1), and their counter-receptors such as intercellular cell adhesion molecule (ICAM)-1 and ICAM-2, junctional adhesion molecule (JAM)-A, JAM-C and receptor for advanced glycation end products (RAGE) are crucial to promote polymorphonuclear leukocyte (neutrophil, PMN) recruitment. The underlying mechanisms of ligand-specific bindings in this cascade remain incompletely known. We compared the dynamic force spectrum for various LFA-1/Mac-1-ligand bonds using single molecule atomic force microscopy (AFM) and tested their functions to mediate PMN recruitment under in vitro shear flow...
December 27, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29278639/pioglitazone-attenuates-atherosclerosis-in-diabetic-mice-by-inhibition-of-receptor-for-advanced-glycation-end-product-rage-signaling
#13
Hongli Gao, Hongwei Li, Weiping Li, Xuhua Shen, Beibing Di
BACKGROUND Peroxisome proliferator-activated receptor-g (PPAR-g) exhibits anti-inflammatory and anti-diabetic properties, and is protective against cardiovascular diseases. This study aimed to determine the effects of a PPAR-g agonist pioglitazone on atherogenesis in an ApoE knockout mouse (ApoE-/-) diabetic mouse model and in a cultured vascular smooth muscle cells (VSMCs) model. MATERIAL AND METHODS Male ApoE-/- mice were rendered diabetic by 5 daily intraperitoneal injections of streptozotocin. Pioglitazone (20 mg/kg/d) or PPAR-γ inhibitor GW9662 (1 mg/kg/d) were administered for 12 weeks...
December 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29276218/signal-diversity-of-receptor-for-advanced-glycation-end-products
#14
REVIEW
Masakiyo Sakaguchi, Rie Kinoshita, Endy Widya Putranto, I Made Winarsa Ruma, I Wayan Sumardika, Chen Youyi, Naoko Tomonobu, Ken-Ichi Yamamoto, Hitoshi Murata
The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane...
December 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29262395/salvianolic-acid-a-protects-against-diabetic-nephropathy-through-ameliorating-glomerular-endothelial-dysfunction-via-inhibiting-age-rage-signaling
#15
Biyu Hou, Guifen Qiang, Yuerong Zhao, Xiuying Yang, Xi Chen, Yu Yan, Xiaobo Wang, Chenge Liu, Li Zhang, Guanhua Du
BACKGROUND/AIMS: Glomerular endothelium dysfunction leads to the progression of renal architectonic and functional abnormalities in early-stage diabetic nephropathy (DN). Advanced glycation end products (AGEs) and receptor for AGEs (RAGE) are proved to play important roles in diabetic nephropathy. This study investigated the role of Salvianolic acid A (SalA) on early-stage DN and its possible underlying mechanism. METHODS: In vitro AGEs formation and breaking rate were measured to illustrate the effect of SalA on AGEs...
December 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29261755/interaction-between-environment-nutrient-derived-metabolites-and-immunity-a-possible-role-in-malaria-susceptibility-resistance-in-fulani-and-dogon-of-mali
#16
Karim Traore, Mahamadou A Thera, Anne-Lise Bienvenu, Charles Arama, Guillaume Bonnot, Adeline Lavoignat, Ogobara K Doumbo, Stephane Picot
The role of some nutrient-derived metabolites on the innate and adaptive immune responses is now established. Global research approach investigating the interplay between environment, lifestyle and the host's immune responses is crucial in the understanding of malaria susceptibility. Advanced Glycation end products (AGE), which are food-derived metabolites result from the link between reducing sugar and amino group of proteins, lipids or nucleic acids. The level of exposure to AGEs varies depending on the type of diet...
2017: PloS One
https://www.readbyqxmd.com/read/29258824/hypoxia-increased-rage-expression-regulates-chemotaxis-and-pro-inflammatory-cytokines-release-through-nuclear-translocation-of-nf-%C3%AE%C2%BA-b-and-hif1%C3%AE-in-thp-1%C3%A2-cells
#17
Wei Bai, Jing Zhou, Na Zhou, Qin Liu, Jian Cui, Wei Zou, Wei Zhang
The potential role of hypoxia in mediating the receptor for advanced glycation end products (RAGE) expression deserves to be confirmed. And the role of RAGE in hypoxia-induced chemotaxis and inflammation is still unclear. In present study, THP-1 cells were pretreated with siRNA to block HIF1α, NF-κ B, or RAGE, followed by exposed to hypoxia (combined with H2O2 or SNP), and then RAGE expression, nuclear translocation of HIF1α and NF-κ B, release of TNF-α and IL-1β, as well as expression of MCP-1 and CCR2 were measured...
December 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29258218/in-vitro-investigation-of-the-interaction-of-tolbutamide-and-losartan-with-human-serum-albumin-in-hyperglycemia-states
#18
Agnieszka Szkudlarek, Danuta Pentak, Anna Ploch, Jadwiga Pożycka, Małgorzata Maciążek-Jurczyk
Serum albumin is exposed to numerous structural modifications which affect its stability and activity. Glycation is one of the processes leading to the loss of the original properties of the albumin and physiological function disorder. In terms of long lasting states of the hyperglycemia, Advanced Glycation End-products (AGEs) are formed. AGEs are responsible for cellular and tissue structure damage that cause the appearance of a number of health consequences and premature aging. The aim of the present study was to analyze the conformational changes of serum albumin by glycation-"fructation"-using multiple spectroscopic techniques, such as absorption (UV-Vis), fluorescence (SFM), circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy and evaluate of possible alteration of binding and competition between tolbutamide (TB, a first-generation sulfonylurea oral hypoglycemic drug) and losartan (LOS, an angiotensin II receptor (AT₁) blocker used in hypertension (1st line with a coexisting diabetes)) in binding to non-glycated (HSA) and glycated (gHSAFRC) human serum albumin in high-affinity binding sites...
December 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29248482/targeted-inhibition-of-rage-reduces-amyloid-%C3%AE-influx-across-the-blood-brain-barrier-and-improves-cognitive-deficits-in-db-db-mice
#19
Hao Wang, Fang Chen, Yi-Feng Du, Yan Long, Miranda N Reed, Mei Hu, Vishnu Suppiramaniam, Hao Hong, Su-Su Tang
AIMS: To investigate restorative effects of the receptor for advanced glycation end products (RAGE)-specific inhibitor FPS-ZM1 on abnormal amyloid (Aβ) influx across the blood brain-barrier (BBB) and cognitive deficits in db/db mice. METHODS: Aβ influx across the BBB was determined by intra-arterial infusion of 125I-Aβ1-40. Receptor for advanced glycation end products (RAGE), Aβ, NF-κB p65, caspase-3, Bax, Bcl-2, PSD-95 and synaptophysin were assayed by Western blot, immunohistochemistry or RT-PCR...
December 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29246793/long-term-treadmill-exercise-attenuates-a%C3%AE-burdens-and-astrocyte-activation-in-app-ps1-mouse-model-of-alzheimer-s-disease
#20
Jing Zhang, Yunliang Guo, Yongxiang Wang, Lin Song, Rui Zhang, Yifeng Du
Alzheimer's disease (AD) is a devastating disease characterized with progressive neurodegenerative disorders in the elderly. Epidemiological and clinical studies reported that lifestyle factors could halt the progression of AD, especially physical exercise. In the present work, we investigated the effects of long-term treadmill exercise on the pathological cascades of AD in APP/PS1 mice. After exercise for 5 months, Aβ deposition was significantly ameliorated in terms of Aβ area fraction, plaque number and size...
December 12, 2017: Neuroscience Letters
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