keyword
MENU ▼
Read by QxMD icon Read
search

Collecting duct

keyword
https://www.readbyqxmd.com/read/29162437/mouse-model-of-alagille-syndrome-and-mechanisms-of-jagged1-missense-mutations
#1
Emma R Andersson, Indira V Chivukula, Simona Hankeova, Marika Sjöqvist, Yat Long Tsoi, Daniel Ramsköld, Jan Masek, Aiman Elmansuri, Anita Hoogendoorn, Elenae Vazquez, Helena Storvall, Julie Netušilová, Meritxell Huch, Björn Fischler, Ewa Ellis, Adriana Contreras, Antal Nemeth, Kenneth C Chien, Hans Clevers, Rickard Sandberg, Vitezslav Bryja, Urban Lendahl
BACKGROUND & AIMS: Alagille syndrome is a genetic disorder characterized by cholestasis, ocular abnormalities, characteristic facial features, heart defects, and vertebral malformations. Most cases are associated with mutations in JAGGED1 (JAG1), which encodes a Notch ligand, although it is not clear how these contribute to disease development. We aimed to develop a mouse model of Alagille syndrome to elucidate these mechanisms. METHODS: Mice with a missense mutation (H268Q) in Jag1 (Jag1(+)/(Ndr) mice) were outbred to a C3H/C57bl6 background to generate a mouse model for Alagille syndrome (Jag1(Ndr/Ndr) mice)...
November 18, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29162218/renal-histology-and-mri-in-a-25-year-old-japanese-man-with-nephronophthisis-4%C3%A2
#2
Daisuke Takada, Akinari Sekine, Junko Yabuuchi, Yuta Kogure, Toshiharu Ueno, Masayuki Yamanouchi, Keiichi Sumida, Tatsuya Suwabe, Noriko Hayami, Junichi Hoshino, Kenmei Takaichi, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Yoshifumi Ubara
We investigated a 25-year-old Japanese man who had polycystic kidneys and end-stage renal failure without a positive family history. Ultrasonography revealed enlarged kidneys with increased echogenicity and multiple cystic lesions. MRI showed replacement of both kidneys by cystic lesions without definite walls. Renal biopsy demonstrated interstitial fibrosis, especially at the corticomedullary junction. The residual tubular system showed starfish-like disruption. Tubules with cystic dilation were mainly the distal loop of Henle and the distal tubules since immunohistochemical staining was positive for cytokeratin 7 (the distal loop of Henle and the distal tubule) and Tamm-Horsfall protein (the distal loop of Henle), while being negative for aquaporin 3 (the collecting duct) and CD10 (proximal tubule)...
November 22, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29158444/hnf1b-controls-epithelial-organization-and-cell-polarity-during-ureteric-bud-branching-and-collecting-duct-morphogenesis
#3
Audrey Desgrange, Claire Heliot, Ilya Skovorodkin, Saad U Akram, Janne Heikkilä, Veli-Pekka Ronkainen, Ilkka Miinalainen, Seppo J Vainio, Silvia Cereghini
Kidney development depends critically on proper ureteric bud branching giving rise to the entire collecting duct system. The transcription factor HNF1B is required for the early steps of ureteric bud branching. Yet, the molecular and cellular events regulated by HNF1B are poorly understood. We report that specific removal of Hnf1b from the ureteric bud leads to defective cell-cell contacts and apico-basal polarity during the early branching events. High resolution ex vivo imaging combined with a membranous fluorescent reporter strategy show decreased mutant cell-rearrangements during mitosis-associated cell dispersal and severe epithelial disorganisation...
November 20, 2017: Development
https://www.readbyqxmd.com/read/29155857/impaired-aqp2-trafficking-in-fxyd1-knockout-mice-a-role-for-fxyd1-in-regulated-vesicular-transport
#4
Elena Arystarkhova, Richard Bouley, Yi Bessie Liu, Kathleen J Sweadner
The final adjustment of urine volume occurs in the inner medullary collecting duct (IMCD), chiefly mediated by the water channel aquaporin 2 (AQP2). With vasopressin stimulation, AQP2 accumulation in the apical plasma membrane of principal cells allows water reabsorption from the lumen. We report that FXYD1 (phospholemman), better known as a regulator of Na,K-ATPase, has a role in AQP2 trafficking. Daytime urine of Fxyd1 knockout mice was more dilute than WT despite similar serum vasopressin, but both genotypes could concentrate urine during water deprivation...
2017: PloS One
https://www.readbyqxmd.com/read/29152785/ultrastructure-of-plasma-cells-in-harderian-gland-of-laying-hens
#5
P Bejdić, R Avdić, Lj Amidžić, V Ćutahija, F Tandir, N Hadžiomerović, A Katica, N Mlaćo
Ultrastructure of plasma cells in Harderian gland was investigated using the transmission electron microscopy. For this research, we examined the glands of 32 laying hens collected at 1, 7, 20 and 40 days and 4, 6, 8 and 12 months of the birds' ages. The research showed that the stroma of the gland contains a large number of lymphocytes and plasma cells. Most of the plasma cells are mature, but morphologically do not show productive activity. Only some individual plasma cells, situated under the secretory epithelium of primary and secondary ducts, have extremely dilated cisternae of rough endoplasmic reticulum which contain moderately dense, granular material...
November 19, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29151598/gene-expression-single-cell-rna-sequencing-of-collecting-duct-cells
#6
Susan J Allison
No abstract text is available yet for this article.
November 20, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29150368/the-utility-of-ercp-in-pediatric-pancreatic-trauma
#7
Eric H Rosenfeld, Adam M Vogel, Denise B Klinkner, Mauricio Escobar, Barbara Gaines, Robert Russell, Brendan Campbell, Hale Wills, Anthony Stallion, David Juang, Rajan K Thakkar, Jeffrey Upperman, Mubeen Jafri, Randall Burd, Bindi J Naik-Mathuria
BACKGROUND/PURPOSE: Endoscopic retrograde cholangiopancreatography (ERCP) is an adjunct for pediatric pancreatic injury management, but its use and utility in pediatric patients are unclear. We set out to evaluate the use of ERCP and its effects on outcomes. METHODS: A retrospective review was performed for children who had pancreatic injuries at 22 pediatric trauma centers between 2010 and 2015. ERCP details and outcomes were collected. Analysis was performed using descriptive statistics and Wilcoxon rank-sum tests...
October 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29145864/intraductal-tubulopapillary-neoplasm-itpn-of-the-pancreas-associated-with-an-invasive-component-a-case-report-with-review-of-the-literature
#8
Stefanie Kuscher, Hartmut Steinle, Afschin Soleiman, Dietmar Öfner, Stefan Schneeberger, Georg Oberhuber
BACKGROUND: Intraductal tubulopapillary neoplasm (ITPN) depicts a distinct entity in the subgroup of premalignant epithelial tumors of the pancreas. Although the histomorphological and immunophenotypical characterization of ITPN has been described by several authors in terms of report of case series in the past, the rarity of that tumor subtype and similarity to other entities still makes identification of ITPN a challenge for radiologists and pathologists. To date, little is known about tubulopapillary carcinoma that can evolve from ITPN...
November 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29138817/reduced-triglyceride-accumulation-due-to-overactivation-of-farnesoid-x-receptor-signaling-contributes-to-impaired-liver-regeneration-following-50-hepatectomy-in-extra%C3%A2-cholestatic-liver-tissue
#9
Wen-Jun Jia, Shi-Quan Sun, Luo-Shun Huang, Qiao-Li Tang, Yu-Dong Qiu, Liang Mao
The aim of the present study was to investigate the role of triglyceride metabolism in the effect of obstructive cholestasis on liver regeneration following 50% partial hepatectomy (PH). Obstructive cholestatic rat models were achieved via ligation of the common bile duct (BDL). Following comparisons between hepatic pathological alterations with patients with perihilar cholangiocarcinoma, rats in the 7 day post‑BDL group were selected as the BDL model for subsequent experiments. Liver weight restoration, proliferating cell nuclear antigen labeling index, cytokine and growth factor expression levels, and hepatic triglyceride content were evaluated to analyze liver regeneration post‑PH within BDL and control group rats...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29136945/mitochondria-protection-as-a-mechanism-underlying-the-hepatoprotective-effects-of-glycine-in-cholestatic-mice
#10
Reza Heidari, Vahid Ghanbarinejad, Hamidreza Mohammadi, Asrin Ahmadi, Mohammad Mehdi Ommati, Narges Abdoli, Fatemeh Aghaei, Athena Esfandiari, Negar Azarpira, Hossein Niknahad
Cholestasis is the stoppage of bile flow which could lead to serious clinical complications if not managed. Cytotoxic bile acids are involved in the pathogenesis of liver injury during cholestasis. There are no promising pharmacological interventions against cholestasis and its associated complications. This study examined the impact of glycine supplementation on liver mitochondria as a major target of bile acids-induced toxicity during cholestasis. Mice underwent BDL operation and received glycine (0.25% and 1% w:v in drinking water)...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29135497/pancreatic-chymotrypsin-activity-rather-than-amylase-level-better-predicts-postoperative-pancreatic-fistula
#11
Suguru Yamashita, Takeaki Ishizawa, Kazuhiro Mori, Kazuteru Monden, Yugo Kuriki, Mako Kamiya, Junichi Kaneko, Nobuhisa Akamatsu, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Yasuteru Urano, Norihiro Kokudo
OBJECTIVE: To assess the predictive value of chymotrypsin activity in pancreatic juice on clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatic resection, since pancreatic peptidases rather than glycolytic enzymes play a pivotal role in causing tissue damage due to pancreatic leakage. BACKGROUND: The risk of CR-POPF has been estimated based on amylase level in abdominal drainage fluid. METHODS: Eighty-one consecutive patients underwent pancreatoduodenectomy, and postoperative pancreatic juice and drainage fluids were collected for 14 days...
November 13, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29134279/dietary-k-and-cl-independently-regulate-basolateral-conductance-in-principal-and-intercalated-cells-of-the-collecting-duct
#12
Viktor N Tomilin, Oleg Zaika, Arohan R Subramanya, Oleh Pochynyuk
The renal collecting duct contains two distinct cell types, principal and intercalated cells, expressing potassium Kir4.1/5.1 (KCNJ10/16) and chloride ClC-K2 (ClC-Kb in humans) channels on their basolateral membrane, respectively. Both channels are thought to play important roles in controlling systemic water-electrolyte balance and blood pressure. However, little is known about mechanisms regulating activity of Kir4.1/5.1 and ClC-K2/b. Here, we employed patch clamp analysis at the single channel and whole cell levels in freshly isolated mouse collecting ducts to investigate regulation of Kir4...
November 13, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29131404/efficacy-of-radiation-therapy-for-the-treatment-of-sialocele-in-dogs
#13
V J Poirier, S Mayer-Stankeová, J Buchholz, D M Vail, B Kaser Hotz
BACKGROUND: Sialocele is a collection of saliva that has leaked from a damaged salivary gland or duct and is surrounded by granulation tissue. Surgery is the recognized first-line treatment. Recurrence rate after surgery is 5-14%. Salivary gland tissue is very sensitive to radiation therapy (RT). HYPOTHESIS/OBJECTIVES: Radiation therapy will be useful for the treatment of sialocele. The aims were to characterize response rate and clinical course of dogs with sialocele treated with RT and to determine a starting dose for clinical use...
November 13, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29129525/multicenter-evaluation-of-the-clinical-utility-of-laparoscopy-assisted-ercp-in-patients-with-roux-en-y-gastric-bypass
#14
Ali M Abbas, Andrew T Strong, David L Diehl, Brian C Brauer, Iris H Lee, Rebecca Burbridge, Jaroslav Zivny, Jennifer T Higa, Marcelo Falcão, Ihab I El Hajj, Paul Tarnasky, Brintha K Enestvedt, Alexander R Ende, Adarsh M Thaker, Rishi Pawa, Priya Jamidar, Kartik Sampath, Eduardo Guimarães Hourneaux de Moura, Richard S Kwon, Alejandro L Suarez, Murad Aburajab, Andrew Y Wang, Mohammad H Shakhatreh, Vivek Kaul, Lorna Kang, Thomas E Kowalski, Rahul Pannala, Jeffrey Tokar, A Aziz Aadam, Demetrios Tzimas, Mihir S Wagh, Peter V Draganov, M D The LA-Ercp Research Group Jeffrey Ponsky, Bruce D Greenwald, Lance T Uradomo, Alyson A McGhan, Shahrad Hakimian, Andrew Ross, Stuart Sherman, Benjamin L Bick, Christopher E Forsmark, Dennis Yang, Anand Gupte, Shailendra Chauhan, Steven J Hughes, Karen Saks, Gennadiy Bakis, Adam W Templeton, Michael Saunders, Alireza Sedarat, John A Evans, Thiruvengadam Muniraj, Timothy B Gardner, Almino C Ramos, Marco Aurelio Santo, Andrew Nett, Gregory A Coté, B Joseph Elmunzer, Kulwinder S Dua, Michael J Nosler, Daniel S Strand, Paul Yeaton, Shivangi Kothari, Asad Ullah, Pushpak Taunk, Patrick Brady, Haim Pinkas, Ashley L Faulx, Haroon Shahid, Jordan Holmes, Davinderbir Pannu, Srinadh Komanduri, Juan Carlos Bucobo, Harry Dhaliwal, Alaa Rostom, Brent W Acker
BACKGROUND AND AIMS: The obesity epidemic has led to increased use of Roux-en-Y gastric bypass (RYGB). These patients have an increased incidence of pancreaticobiliary diseases yet standard ERCP is not possible due to surgically altered gastroduodenal anatomy. Laparoscopic-ERCP (LA-ERCP) has been proposed as an option but supporting data are derived from single center small case-series. Therefore, we conducted a large multicenter study to evaluate the feasibility, safety, and outcomes of LA-ERCP...
November 9, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29128370/the-inhibition-of-sphingomyelin-synthase-1-activity-induces-collecting-duct-cells-to-lose-their-epithelial-phenotype
#15
Yamila Romina Brandán, Edith Del Valle Guaytima, Nicolás Octavio Favale, Lucila Gisele Pescio, Norma B Sterin-Speziale, María Gabriela Márquez
Epithelial tissue requires that cells attach to each other and to the extracellular matrix by the assembly of adherens junctions (AJ) and focal adhesions (FA) respectively. We have previously shown that, in renal papillary collecting duct (CD) cells, both AJ and FA are located in sphingomyelin (SM)-enriched plasma membrane microdomains. In the present work, we investigated the involvement of SM metabolism in the preservation of the epithelial cell phenotype and tissue organization. To this end, primary cultures of renal papillary CD cells were performed...
November 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29125546/hereditary-nephrogenic-diabetes-insipidus-pathophysiology-and-possible-treatment-an-update
#16
REVIEW
Serena Milano, Monica Carmosino, Andrea Gerbino, Maria Svelto, Giuseppe Procino
Under physiological conditions, excessive loss of water through the urine is prevented by the release of the antidiuretic hormone arginine-vasopressin (AVP) from the posterior pituitary. In the kidney, AVP elicits a number of cellular responses, which converge on increasing the osmotic reabsorption of water in the collecting duct. One of the key events triggered by the binding of AVP to its type-2 receptor (AVPR2) is the exocytosis of the water channel aquaporin 2 (AQP2) at the apical membrane the principal cells of the collecting duct...
November 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29118690/pneumoperitoneum-after-endoscopic-retrograde-cholangiopancreatography-due-to-rupture-of-intrahepatic-bile-ducts-and-glisson-s-capsule-in-hepatic-metastasis-a-case-report-and-review-of-literature
#17
Zubair Khan, Umar Darr, Mohamad Nawras, Muhammad Bawany, Jacob Bieszczad, Osama Alaradi, Ali Nawras
Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) has been proven to be a safe and effective method for diagnosis and treatment of biliary and pancreatic disorders. Major complications of ERCP include pancreatitis, hemorrhage, cholangitis, and duodenal perforation. We report a third case in literature of pneumoperitoneum after ERCP due to rupture of intrahepatic bile ducts and Glisson's capsule in a peripheral hepatic lesion. Case Report: A 50-year-old male with a history of metastatic pancreatic neuroendocrine tumor and who had a partially covered metallic stent placed in the biliary tree 1 year ago presented to the oncology clinic with fatigue, abdominal pain, and hypotension...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29118564/sex-related-differences-in-predicting-choledocholithiasis-using-current-american-society-of-gastrointestinal-endoscopy-risk-criteria
#18
Ankit Chhoda, Deepanshu Jain, Shashideep Singhal
Background: American Society of Gastrointestinal Endoscopy (ASGE) criteria is widely used to predict probability of choledocholithiasis among patients with symptomatic gallstone disease but does not take sex into consideration. Methods: The cohort study included patients who underwent either endoscopic retrograde cholangiopancreatography or intraoperative cholangiography for suspected choledocholithiasis at our medical center. Clinical, laboratory and radiological data were collected for each patient and used to stratify them based on the ASGE risk criteria for choledocholithiasis...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29117938/functional-characterization-of-avpr2-mutants-found-in-turkish-patients-with-nephrogenic-diabetes-insipidus
#19
Beril Erdem, Angela Schulz, Emel Saglar, Ferhat Deniz, Torsten Schoneberg, Hatice Mergen
Diabetes insipidus is a rare disorder characterized by an impairment in water balance because of the inability to concentrate urine. While central Diabetes insipidus is caused by mutations in the AVP, the reason for genetically determined nephrogenic Diabetes insipidus can be mutations in AQP2 or AVPR2. After release of AVP from posterior pituitary into blood stream it binds to AVPR2 which is one of the receptors for AVP and is mainly expressed in principal cells of collecting ducts of kidney. Receptor activation increases cAMP levels in principal cells, resulting in the incorporation of AQP2 into the membrane, finally increasing water reabsorption...
November 8, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29117728/different-pattern-of-risk-factors-for-post-ercp-pancreatitis-in-patients-with-biliary-stricture
#20
Liang Zheng, Xiangping Wang, Qin Tao, Shuhui Liang, Biaoluo Wang, Hui Luo, Rongchun Zhang, Liyue Zheng, Shengye Yang, Jie Chen, Yanglin Pan, Xuegang Guo
OBJECTIVE: To identify possible risk factors associated with post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in biliary stricture (BS), common bile duct stone (CBDS) and unselected patients. MATERIALS AND METHODS: Consecutive ERCP patients with native papilla from January 2010 to December 2014 in Xijing Hospital were eligible. Patient-related and procedure-related parameters were collected retrospectively. The primary outcome was PEP...
November 9, 2017: Scandinavian Journal of Gastroenterology
keyword
keyword
23372
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"