keyword
https://read.qxmd.com/read/38523582/post-diagnosis-serum-25-hydroxyvitamin-d-concentrations-in-women-treated-for-breast-cancer-participating-in-a-lifestyle-trial-in-italy
#21
JOURNAL ARTICLE
A Fassio, G Porciello, G Carioli, E Palumbo, S Vitale, A Luongo, C Montagnese, M Prete, M Grimaldi, R Pica, E Rotondo, L Falzone, I Calabrese, A Minopoli, B Grilli, M Cuomo, P C Fiorillo, C Evangelista, E Cavalcanti, M De Laurentiis, D Cianniello, C Pacilio, M Pinto, G Thomas, M Rinaldo, M D'Aiuto, D Serraino, S Massarut, A Steffan, F Ferraù, R Rossello, F Messina, F Catalano, G Adami, F Bertoldo, M Libra, A Crispo, E Celentano, C La Vecchia, L S A Augustin, D Gatti
OBJECTIVE: To report cross-sectionally serum levels of 25-hydroxyvitamin D [25(OH)D] in women living in Italy within 12 months from breast cancer (BC) diagnosis. METHODS: Baseline data were obtained from 394 women diagnosed with primary BC, enrolled from 2016 to 2019 in a lifestyle trial conducted in Italy. Subjects' characteristics were compared between two 25(OH)D concentrations (hypovitaminosis D<20 and ≥20 ng/mL) with the Chi-squared test or Fisher's exact test for small-expected counts...
March 22, 2024: Reumatismo
https://read.qxmd.com/read/38523351/breasts-as-a-perceived-barrier-to-physical-activity-in-mexican-women-a-cross-sectional-study
#22
JOURNAL ARTICLE
Gabriela Valles-Verdugo, Ivan Renteria, Julio Gómez-Figueroa, Mario Villarreal-Ángeles, Paulina Ochoa-Martínez, Javier Hall-López, Juan Gallegos-Ramírez, Yamileth Chacón-Araya, José Moncada-Jiménez
BACKGROUND: Scarce evidence exists on barriers to physical activity in Mexican women. Despite evidence from other countries, no research has investigated the influence of the breast on PA in this population. OBJECTIVE: To determine the association between the breast and physical activity in Mexican women. DESIGN: Cross-sectional observational study. METHODS: Volunteers were 279 Mexican women from Veracruz, Durango, and Baja California states, who completed a paper survey of their demographics, brassiere characteristics, breast pain, and frequency and amounts of weekly physical activity...
2024: Women's Health
https://read.qxmd.com/read/38522915/characteristics-of-suspicious-breast-lesions-visible-only-on-mr-imaging-is-it-possible-to-classify-into-immediate-biopsy-and-careful-observation-groups
#23
JOURNAL ARTICLE
Ryozo Kai, Mitsuhiro Tozaki, Yuya Koike, Aya Nagata, Kanae Taruno, Yoshimitsu Ohgiya
PURPOSE: To investigate the characteristics of suspicious MRI-only visible lesions and to explore the validity of subcategorizing these lesions into the following two groups: lesions that would require immediate biopsy (4Bi) and lesions for which careful clinical follow-up could be recommended (4Fo). METHODS: A retrospective review of 108 MRI-only visible lesions in 106 patients who were diagnosed as Breast Imaging Reporting and Data System (BI-RADS) category 4 between June 2018 and June 2022 at our institution was performed by two radiologists...
March 22, 2024: Magnetic Resonance in Medical Sciences: MRMS
https://read.qxmd.com/read/38521539/breast-masses-with-rim-enhancement-on-contrast-enhanced-mammography-morphological-and-enhancement-features-for-diagnosis-and-differentiation-of-benign-and-malignant
#24
JOURNAL ARTICLE
Chanjuan Wen, Sina Wang, Mengwei Ma, Zeyuan Xu, Fengxia Zeng, Hui Zeng, Xin Liao, Zilong He, Weimin Xu, Weiguo Chen
OBJECTIVE: To investigate the imaging characteristics and clinicopathological features of rim enhancement of breast masses demonstrated on contrast-enhanced mammography(CEM). METHODS: 67 cases of breast lesions confirmed by pathology and showing rim enhancement on CEM examinations were analyzed. The lesions were divided into benign and malignant groups, and the morphological and enhanced features were described. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated separately for each morphology descriptor to evaluate the diagnostic ability of each indicator...
March 23, 2024: British Journal of Radiology
https://read.qxmd.com/read/38521300/construction-of-a-soybean-protein-isolate-polysaccharide-based-whole-muscle-meat-analog-physical-properties-and-freeze-thawing-stability-study
#25
JOURNAL ARTICLE
Bing Cui, Xinyue Zeng, Hongshan Liang, Jing Li, Bin Zhou, Di Wu, Xuezhu Du, Bin Li
A growing interest has arisen in recreating real meat by mimicking its texture characteristics and muscle fiber structure. Our previous work successfully created meat analog fiber based on soybean protein isolate (SPI) and sodium alginate (SA) with the wet-spinning method. In this work, we analyzed the microstructure, texture profile, and water retainability of the assembled plant-based whole muscle meat analog (PMA) made of SPI/SA-based meat analog fiber and systematically studied the effect of different combinations and contents of transglutaminase (TG), salt, and soybean oil on the rheological behavior of the formulated adhesive...
March 21, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38520804/women-s-attitudes-and-perspectives-on-the-use-of-artificial-intelligence-in-the-assessment-of-screening-mammograms
#26
JOURNAL ARTICLE
Åsne Sørlien Holen, Marit Almenning Martiniussen, Marie Burns Bergan, Nataliia Moshina, Tone Hovda, Solveig Hofvind
PURPOSE: To investigate attitudes and perspectives on the use of artificial intelligence (AI) in the assessment of screening mammograms among women invited to BreastScreen Norway. METHOD: An anonymous survey was sent to all women invited to BreastScreen Norway during the study period, October 10, 2022, to December 25, 2022 (n = 84,543). Questions were answered on a 10-point Likert scale and as multiple-choice, addressing knowledge of AI, willingness to participate in AI studies, information needs, confidence in AI results and AI assisted reading strategies, and thoughts on concerns and benefits of AI in mammography screening...
March 16, 2024: European Journal of Radiology
https://read.qxmd.com/read/38520019/linc00115-promotes-chemoresistant-breast-cancer-stem-like-cell-stemness-and-metastasis-through-setdb1-plk3-hif1%C3%AE-signaling
#27
JOURNAL ARTICLE
Fei Luo, Mingda Zhang, Bowen Sun, Chenxin Xu, Yi Yang, Yingwen Zhang, Shanshan Li, Guoyu Chen, Ceshi Chen, Yanxin Li, Haizhong Feng
BACKGROUND: Cancer stem-like cell is a key barrier for therapeutic resistance and metastasis in various cancers, including breast cancer, yet the underlying mechanisms are still elusive. Through a genome-wide lncRNA expression profiling, we identified that LINC00115 is robustly upregulated in chemoresistant breast cancer stem-like cells (BCSCs). METHODS: LncRNA microarray assay was performed to document abundance changes of lncRNAs in paclitaxel (PTX)-resistant MDA-MB-231 BCSC (ALDH+ ) and non-BCSC (ALDH- )...
March 22, 2024: Molecular Cancer
https://read.qxmd.com/read/38519482/proteomic-profiling-reveals-that-esr1-mutations-enhance-cyclin-dependent-kinase-signaling
#28
JOURNAL ARTICLE
Tommaso De Marchi, Chun-Fui Lai, Georgia M Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H Saal, Johan Malmström, Simak Ali, Emma Niméus
Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibitors. ESR1 mutations promote constitutive ER activity and affect other signaling pathways, allowing cancer cells to proliferate by employing mechanisms within and without direct regulation by the ER. Although subjected to extensive genetic and transcriptomic analyses, understanding of protein alterations remains poorly investigated...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38518977/non-sclerosing-t-cell-and-sclerosing-b-cell-lymphocytic-lobulitis-in-diagnostic-breast-biopsies-clinical-imaging-and-pathologic-features
#29
JOURNAL ARTICLE
Marie-Helene Ngo, Geraldine S Pinkus, Eren D Yeh, Jane E Brock, Stephanie Schulte, Susan C Lester
Lymphocytic lobulitis (LL) is characterized by prominent lymphocytic infiltrates centered on lobules. Sclerosing lymphocytic lobulitis (SCLL) associated with diabetes mellitus (DM) or autoimmune disease (AI) was the first type to be described. Subsequently, non-sclerosing LL (NSCLL) was reported as an incidental finding in prophylactic mastectomies due to high risk germline mutations or a family history of breast cancer. The two types of LL were distinguished by stromal features and a predominant population of B-cells in the former and T-cells in the latter...
March 20, 2024: Human Pathology
https://read.qxmd.com/read/38518464/primary-cutaneous-apocrine-carcinoma-a-challenging-case-report
#30
Nayssem Khessairi, Yasmine Fertani, Saida Sakhri, Imen Abbess, Ines Zemni, Tarek Ben Dhiab
INTRODUCTION: Primary cutaneous apocrine carcinomas of the axilla represents an extremely rare entity, with <200 cases reported in the literature. It can be challenging, even almost impossible, to distinguish histologically from metastases of breast origin. We herein present the first case of an axillary cutaneous apocrine adenocarcinoma followed and treated in our institute. CASE PRESENTATION: A 58-year-old man with a history of myopathy, presented for a right axillary swelling...
March 14, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38518130/probabilistic-analysis-of-color-doppler-ultrasonography-for-breast-cancer-detection-in-asymptomatic-individuals
#31
JOURNAL ARTICLE
Jing Liu, Yang Zhao, Heling Zhang, Yupin Song
OBJECTIVE: This study aims to investigate and analyze the detection rate of breast cancer utilizing color Doppler ultrasonography in asymptomatic individuals. METHODS: A cohort of 500 female patients who underwent physical examinations at our hospital from January 2018 to August 2020 was selected for this research. The diagnosis involved conventional surgical palpation and color Doppler ultrasound in all cases. The control group underwent conventional surgical palpation, while the study group utilized the color Doppler ultrasound diagnosis method...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38517765/cancer-associated-fibroblasts-modulate-the-cytotoxicity-of-anti-cancer-drugs-in-breast-cancer-an-in-vitro-study
#32
JOURNAL ARTICLE
Dharambir Kashyap, Shalmoli Bhattacharya, Santosh Irinike, Siddhant Khare, Ashim Das, Gurpreet Singh, Amanjit Bal
BACKGROUND: Tumour microenvironment (TME) contributes to resistance to anti-cancer drugs through multiple mechanisms including secretion of pro-survival factors by cancer associated fibroblasts (CAFs). In this study, we determined the chemotherapy resistance producing potential of CAFs in molecular subtypes of breast cancer. METHODS: The CAFs were isolated from fresh lumpectomy/mastectomy specimens of different molecular subtypes of breast cancer. The CAFs were cultured and secretome was collected from each breast cancer subtype...
2024: Breast Disease
https://read.qxmd.com/read/38517441/intraoperative-evaluation-of-breast-tissues-during-breast-cancer-operations-using-the-masspec-pen
#33
JOURNAL ARTICLE
Kyana Y Garza, Mary E King, Chandandeep Nagi, Rachel J DeHoog, Jialing Zhang, Marta Sans, Anna Krieger, Clara L Feider, Alena V Bensussan, Michael F Keating, John Q Lin, Min Woo Sun, Robert Tibshirani, Christopher Pirko, Kirtan A Brahmbhatt, Ahmed R Al-Fartosi, Alastair M Thompson, Elizabeth Bonefas, James Suliburk, Stacey A Carter, Livia S Eberlin
IMPORTANCE: Surgery with complete tumor resection remains the main treatment option for patients with breast cancer. Yet, current technologies are limited in providing accurate assessment of breast tissue in vivo, warranting development of new technologies for surgical guidance. OBJECTIVE: To evaluate the performance of the MasSpec Pen for accurate intraoperative assessment of breast tissues and surgical margins based on metabolic and lipid information. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study conducted between February 23, 2017, and August 19, 2021, the mass spectrometry-based device was used to analyze healthy breast and invasive ductal carcinoma (IDC) banked tissue samples from adult patients undergoing breast surgery for ductal carcinomas or nonmalignant conditions...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38515579/risk-factors-of-paclitaxel-induced-peripheral-neuropathy-in-patients-with-breast-cancer-a-prospective-cohort-study
#34
JOURNAL ARTICLE
Sun Lixian, Yu Xiaoqian, Guo Luyan, Zhou Lizhi, Du Rui, Yao Hongyue, Zhao Caijie, Yuan Fenghui
OBJECTIVE: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe adverse reaction in taxane-based chemotherapy. This study aimed to analyze the risk factors of peripheral neuropathy in patients with breast cancer receiving paclitaxel chemotherapy to provide a reference for the early prevention of CIPN. METHODS: We included 350 patients with breast cancer who received chemotherapy for the first time at the Tangshan People's Hospital between August 2022 and June 2023 and were followed for at least 3 months after the end of chemotherapy...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38515559/an-effective-protocol-for-perioperative-venous-thromboembolism-prophylaxis-in-diep-flap-breast-reconstruction-a-single-institution-retrospective-review
#35
JOURNAL ARTICLE
Mathew L Moreno, Hunter Essex, Meredith Collins
BACKGROUND: Deep inferior epigastric artery perforator (DIEP) free flap breast reconstruction is one of the most highly used procedures for autologous breast reconstruction. Many venous thromboembolism (VTE) risk assessment models have been proposed in breast reconstructive surgery, including the widely used Caprini score. However, a paucity of data suggests an effective standardized VTE protocol. The purpose of this study was to determine the rate of VTE in our DIEP flap patients who were treated with this protocol...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38515093/clinical-outcomes-of-screening-and-diagnostic-mammography-in-a-limited-resource-healthcare-system
#36
JOURNAL ARTICLE
Mahmoud Al-Balas, Hamzeh Al-Balas, Zain AlAmer, Ghadeer Al-Taweel, Aseel Ghabboun, Farh Al Bzoor, Sumaia Abumkarab, Tala Abu Bakr, Batool Eleiwat
INTRODUCTION: Breast cancer is a significant public health concern in Jordan. It is the most common cancer among Jordanian women. Despite its high incidence and advanced stage at time of diagnosis, the uptake of breast cancer screening in Jordan is low. This study aims to compare clinical outcomes of both screening and diagnostic mammogram among women in Jordan. METHODS: A retrospective cohort of 1005 women who underwent mammography in breast imaging unit in a tertiary hospital in Jordan...
March 21, 2024: BMC Women's Health
https://read.qxmd.com/read/38513779/a-metabolomics-approach-reveals-metabolic-disturbance-of-human-cholangiocarcinoma-cells-after-parthenolide-treatment
#37
JOURNAL ARTICLE
Yongping He, Qianxue Yu, Xiaoyu Ma, Diya Lv, Hui Wang, Weian Qiu, Xiao Fei Chen, Yang Jiao, Yue Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Tanacetum parthenium (L.) Schultz-Bip, commonly known as feverfew, has been traditionally used to treat fever, migraines, rheumatoid arthritis, and cancer. Parthenolide (PTL), the main bioactive ingredient isolated from the shoots of feverfew, is a sesquiterpene lactone with anti-inflammatory and antitumor properties. Previous studies showed that PTL exerts anticancer activity in various cancers, including hepatoma, cholangiocarcinoma, acute myeloid leukemia, breast, prostate, and colorectal cancer...
March 19, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38513413/vaginal-bleeding-imitated-rape-in-a-6-year-old-girl-a-case-report-about-granulosa-cell-tumor-as-a-reason-of-peripheral-precocious-puberty
#38
Davoud Amirkashani, Seyyed Javad Nasiri, Samayeh Dadakhani, Nafiseh Mortazavi, Mina Khoshkbarforoushan
INTRODUCTION: Although female victims of sexual child abuse present with symptoms such as local pain and vaginal bleeding, however, before any definitive diagnosis a comprehensive physical examination along with a detailed history related to vaginal bleeding should be taken from the patient. Undoubtedly, we must not forget that only one of the causes of vaginal bleeding is rape. Therefore, before making a final diagnosis, other causes of this symptom must be carefully examined. CASE PRESENTATION: The patient was a 6-years-old female who was hospitalized for notable generalized abdominal distention, acute lower abdomen pain associated with nausea and mild fever lasting 5 days progressively worsening, thelarche and vaginal bleeding...
March 19, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38513380/uncovering-the-effect-and-mechanism-of-jiawei-xiaoyao-wan-in-treating-breast-cancer-complicated-with-depression-based-on-network-pharmacology-and-experimental-analysis
#39
JOURNAL ARTICLE
Yongtao Bai, Lianjie Niu, Lihua Song, Guoliang Dai, Wenzhou Zhang, Baoxia He, Wenqing San, Shuolei Li
BACKGROUND: Depression is a clinically common co-morbidity in breast cancer cases that brings negative outcomes on quality of life and potentially survival. Jiawei Xiaoyao Wan (JXW) is widely used in treating breast cancer and depressive disorder, but its potential pharmacological mechanisms remain elusive. PURPOSE: We aimed to explore the dual therapeutic effects and mechanisms of JXW acting on breast cancer complicated with depression (BCCD) by network pharmacology and in vivo experimental verification...
February 7, 2024: Phytomedicine
https://read.qxmd.com/read/38512534/endoscopic-mastectomy-followed-by-immediate-breast-reconstruction-with-fat-grafting-for-breast-cancer
#40
JOURNAL ARTICLE
Kazutaka Narui, Toshihiko Satake, Takashi Ishikawa, Mayu Muto, Yui Tsunoda, Akimitsu Yamada, Kei Kawashima, Natsuki Uenaka, Yoshie Fujiwara, Masanori Oshi, Shoko Adachi, Chiho Suzuki, Tomoko Wada, Shinya Yamamoto, Mikiko Tanabe, Jiro Maegawa, Itaru Endo
BACKGROUND: Although endoscopic mastectomy has been associated with good tolerance and enhanced patient satisfaction, limitations such as the implant or flap size for reconstruction with small incisions remain unresolved. Fat grafting (FG) can expand tissue volume with pinhole skin incisions. Herein, we evaluated the safety and efficacy of endoscopic mastectomy followed by immediate FG. METHODS: Patients who underwent endoscopic mastectomy with immediate FG reconstruction from 2015 to 2021 were retrospectively evaluated to establish surgical outcomes and prognosis...
March 21, 2024: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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