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https://www.readbyqxmd.com/read/29684340/myeloid-sarcoma-with-megakaryoblastic-differentiation-presenting-as-a-breast-mass
#1
Ifeyinwa E Obiorah, Metin Ozdemirli
Myeloid sarcoma is an extramedullary tumor that consists of myeloblasts or immature myeloid cells. The neoplasm can occur in any part of the body, including the bone, periosteum, lymph nodes, skin, and soft tissue and they may occur de novo or in association with acute myeloid leukemia, myeloproliferative neoplasms and myelodysplastic syndromes. Most cases display a myelomonocytic or pure monoblastic morphology. Tumors with megakaryoblastic differentiation are extremely uncommon and may occur in association with transformation of a myeloproliferative disorder...
April 17, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29681814/non-gestational-choriocarcinoma-with-widespread-metastases-presenting-with-type-1-respiratory-failure-in-a-39-year-old-female-case-report-and-review-of-the-literature
#2
Louisa Stockton, Elizabeth Green, Baljeet Kaur, Emma De Winton
Introduction: Non-gestational choriocarcinoma (NGCC) is an extremely rare cancer. We report a case presenting in extremis. Case Report: A 39-year-old woman presented with type 1 respiratory failure with a 1-month history of breathlessness. Computed tomography (CT) revealed widespread metastatic disease involving the lungs, liver, pancreas, and breast. Serum β-human chorionic gonadotropin was markedly raised. Over 72 h, she deteriorated and was started on high-flow nasal cannula to facilitate discussions and for comfort...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29680487/spectrum-of-chronic-complications-related-to-silicone-leakage-and-migration
#3
Alexander J Ryu, Katrina N Glazebrook, Naziya Samreen, Philippe R Bauer, Eunhee S Yi, Jay H Ryu
BACKGROUND: Medical silicone is widely used as implants and free injections but the spectrum of complications related to migration or embolization of silicone remains unclear. METHODS: We retrospectively reviewed 79 patients with silicone migration as confirmed on pathology between January 1, 2001 and December 31, 2016. The presenting clinical and imaging features, diagnostic testing, treatment, and outcome were assessed. RESULTS: Nearly all were women and 43% had a history of breast cancer...
April 19, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29680194/the-challenge-of-evaluating-adnexal-masses-in-patients-with-breast-cancer
#4
REVIEW
Tomás Reinert, Angélica Nogueira-Rodrigues, Fabiola Procacci Kestelman, Patricia Ashton-Prolla, Márcia Silveira Graudenz, José Bines
This narrative literature review addresses the problem of an adnexal mass discovered during the course of breast cancer (BC) care, which may represent a benign condition, a metastatic process, or a primary ovarian cancer (OC), clinical scenarios associated with distinct physiopathology and prognosis. Furthermore, the coexistence of BC and OC in the same patient may be owing to a hereditary disorder, deserving specific management strategies and counseling. The initial detection and evaluation of an adnexal mass in a patient with BC requires a high index of suspicion, and the initial workup should include a thorough medical history and physical examination, measurement of tumor markers, complete blood count, and imaging tests...
March 12, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29679754/serum-25-hydroxyvitamin-d-and-breast-cancer-risk-by-pathological-subtype-mcc-spain
#5
Virginia Lope, Adela Castelló, Antonio Mena-Bravo, Pilar Amiano, Nuria Aragonés, Tania Fernández-Villa, Marcela Guevara, Trinidad Dierssen-Sotos, Guillermo Fernandez-Tardón, Gemma Castaño-Vinyals, Rafael Marcos-Gragera, Víctor Moreno, Dolores Salas-Trejo, Marian Diaz-Santos, Madalen Oribe, Isabel Romieu, Manolis Kogevinas, Feliciano Priego-Capote, Beatriz Pérez-Gómez, Marina Pollán
Epidemiologic evidence on the association between vitamin D and breast cancer is still inconclusive. This study analyzes the association between serum 25-hydroxyvitamin D (25(OH)D) and breast cancer risk by pathologic subtype, stage at diagnosis and specific breast cancer risk factors. We conducted a population-based multicase-control study where 546 histologically-confirmed breast cancer cases and 558 population controls, frequently matched by geographic area, age and body mass index, were recruited in 12 Spanish provinces (MCC-Spain)...
April 18, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29679666/glutathione-sensitive-hollow-mesoporous-silica-nanoparticles-for-controlled-drug-delivery
#6
Seyyed Pouya Hadipour Moghaddam, Mostafa Yazdimamaghani, Hamidreza Ghandehari
Tunable glutathione (GSH)-sensitive hollow mesoporous silica nanoparticles (HMSiO2 NPs) were developed using a structural difference-based selective etching strategy. These organosilica hollow nanoparticles contained disulfide linkages (S-S) in the outer shell which were degraded by GSH. The particles were compared with their nonGSH-sensitive tetraethyl orthosilicate (TEOS) HMSiO2 counterparts in terms of their synthesis method, characterization, DOX release profile, and in vitro cytotoxicity in MCF-7 breast cancer cells...
April 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29679549/chm-1-a-novel-microtubule-destabilizing-agent-exhibits-antitumor-activity-via-inducing-the-expression-of-sirt2-in-human-breast-cancer-cells
#7
Chin-Wei Liu, Ying-Chao Lin, Chao-Ming Hung, Bing-Lan Liu, Sheng-Chu Kuo, Chi-Tang Ho, Tzong-Der Way, Chih-Hsin Hung
Breast cancer is a major public health problem throughout the world. In this report, we investigated whether CHM-1, a novel synthetic antimitotic agent could be developed into a potent antitumor agent for treating human breast cancer. CHM-1 induced growth inhibition in MDA-MB-231, MDA-MB-453 and MCF-7 cells in a concentration-dependent manner. Importantly, CHM-1 is less toxic to normal breast (HBL-100) cells. CHM-1 interacted with tubulin, markedly inhibited tubulin polymerization, and disrupted microtubule organization...
April 18, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29678902/development-of-a-breast-cancer-risk-prediction-model-for-women-in-nigeria
#8
Shengfeng Wang, Temidayo O Ogundiran, Adeyinka Ademola, Olayiwola A Oluwasola, Adewunmi O Adeoye, Adenike Sofoluwe, Imran Morhason-Bello, Stella O Odedina, Imaria Agwai, Clement Adebamowo, Millicent Obajimi, Oladosu Ojengbede, Olufunmilayo I Olopade, Dezheng Huo
BACKGROUND: Risk prediction models have been widely used to identify women at higher risk of breast cancer. We aim to develop a model for absolute breast cancer risk prediction for Nigerian women. METHODS: A total of 1,811 breast cancer cases and 2,225 controls from the Nigerian Breast Cancer Study (NBCS, 1998~2015) were included. Subjects were randomly divided into the training and validation sets. Incorporating local incidence rates, multivariable logistic regressions were used to develop the model...
April 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29678617/uncertain-times-a-survey-of-canadian-women-s-perspectives-toward-mammography-screening
#9
Julia Abelson, Laura Tripp, Melissa C Brouwers, Gregory Pond, Jonathan Sussman
Evolving scientific evidence about mammography has raised new questions about the net benefits of organized screening, yet gaps remain about women's current screening practices, knowledge, attitudes and values toward screening to support informed decision making in this area. We addressed this gap through an online survey of 2000 screen-eligible women from Ontario, Canada in January 2016. Likert-scaled and categorical questions were used to collect information about screening practices, knowledge of benefits and risks of screening and underlying attitudes and values toward screening...
April 17, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29678274/preoperative-mri-evaluation-of-lesion-nipple-distance-in-breast-cancer-patients-thresholds-for-predicting-occult-nipple-areola-complex-involvement
#10
G Mariscotti, M Durando, N Houssami, C M Berzovini, F Esposito, M Fasciano, P P Campanino, D Bosco, R Bussone, A Ala, I Castellano, A Sapino, L Bergamasco, P Fonio, G Gandini
AIM: To identify clinically occult nipple-areola complex (NAC) involvement using preoperative magnetic resonance imaging (MRI), to inform selection of patients eligible for nipple-sparing mastectomy (NSM) or skin-sparing mastectomy (SSM). MATERIAL AND METHODS: This was a retrospective study of 195 patients, who had preoperative breast MRI (February 2011 to January 2017) before undergoing surgical treatments (NSM or SSM) for newly diagnosed breast cancer. Tumour features at MRI (mass or non-mass lesion, diameter, lesion-NAC distance [LND]) and pathology (lesion diameter, histopathological type, receptor status) were recorded, as well as the type of surgery (NSM/SSM) and presence (NAC+) or absence (NAC-) of tumour at intraoperative evaluation of retroareolar tissue...
April 17, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29674138/development-and-validation-of-a-liquid-chromatography-tandem-mass-spectrometry-assay-for-azd3965-in-mouse-plasma-and-tumor-tissue-application-to-pharmacokinetic-and-breast-tumor-xenograft-studies
#11
Xiaowen Guan, Donna Ruszaj, Marilyn E Morris
AZD3965, a pyrole pyrimidine derivative, is a potent and orally bioavailable inhibitor of monocarboxylate transporter 1 (MCT1), currently in a Phase I clinical trial in UK for lymphomas and solid tumors. There is currently no published assay for AZD3965. The objectives of this study were to develop and validate a LC/MS/MS assay for quantifying AZD3965 in mouse plasma and tumor tissue. Protein precipitation with 0.1% formic acid in acetonitrile was used for sample preparation. Chromatographic separation was achieved on a C18 column followed by tandem mass spectrometry detection in multiple reaction monitoring mode with utilizing Atmospheric Pressure Chemical Ionization...
March 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29673997/breast-lesion-shape-and-margin-evaluation-bi-rads-based-metrics-understate-radiologists-actual-levels-of-agreement
#12
Mohammad Rawashdeh, Sarah Lewis, Maha Zaitoun, Patrick Brennan
BACKGROUND: While there is much literature describing the radiologic detection of breast cancer, there are limited data available on the agreement between experts when delineating and classifying breast lesions. The aim of this work is to measure the level of agreement between expert radiologists when delineating and classifying breast lesions as demonstrated through Breast Imaging Reporting and Data System (BI-RADS) and quantitative shape metrics. METHODS: Forty mammographic images, each containing a single lesion, were presented to nine expert breast radiologists using a high specification interactive digital drawing tablet with stylus...
April 13, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29672776/postoperative-monitoring-of-free-diep-flap-in-breast-reconstruction-with-near-infrared-spectroscopy-variables-affecting-the-regional-oxygen-saturation
#13
Marzia Salgarello, Domenico Pagliara, Marco Rossi, Giuseppe Visconti, Liliana Barone-Adesi
BACKGROUND:  The timing of surgical reexploration in microanastomotic thrombosis is directly related to the salvage rate of free flap. Near-infrared spectroscopy (NIRS) is a noninvasive technique, which allows a continuous bedside monitoring of flap oxygenation. The current literature is lacking in the assessment of variables able to modify the NIRS monitoring. The aim of this study is to identify patient and flap-related variables that can affect regional oxygen saturation (rSO2 )...
April 19, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29670125/comparison-of-strain-and-shear-wave-elastography-for-qualitative-and-quantitative-assessment-of-breast-masses-in-the-same-population
#14
Hyo Jin Kim, Sun Mi Kim, Bohyoung Kim, Bo La Yun, Mijung Jang, Yousun Ko, Soo Hyun Lee, Heeyeong Jeong, Jung Min Chang, Nariya Cho
We investigated addition of strain and shear wave elastography to conventional ultrasonography for the qualitative and quantitative assessment of breast masses; cut-off points were determined for strain ratio, elasticity ratio, and visual score for differentiating between benign and malignant masses. In all, 108 masses from 94 patients were evaluated with strain and shear wave elastography and scored for suspicion of malignancy, visual score, strain ratio, and elasticity ratio. The diagnostic performance between ultrasonography alone and ultrasonography combined with either type of elastography was compared; cut-off points were determined for strain ratio, elasticity ratio, and visual score...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669579/long-term-prognostic-implications-of-risk-factors-associated-with-tumor-size-a-case-study-of-women-regularly-attending-screening
#15
Fredrik Strand, Keith Humphreys, Johanna Holm, Mikael Eriksson, Sven Törnberg, Per Hall, Edward Azavedo, Kamila Czene
BACKGROUND: Breast cancer prognosis is strongly associated with tumor size at diagnosis. We aimed to identify factors associated with diagnosis of large (> 2 cm) compared to small tumors, and to examine implications for long-term prognosis. METHODS: We examined 2012 women with invasive breast cancer, of whom 1466 had screen-detected and 546 interval cancers that were incident between 2001 and 2008 in a population-based screening cohort, and followed them to 31 December 2015...
April 18, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29668675/correlated-metabolomic-genomic-and-histologic-phenotypes-in-histologically-normal-breast-tissue
#16
Xuezheng Sun, Delisha A Stewart, Rupninder Sandhu, Erin L Kirk, Wimal W Pathmasiri, Susan L McRitchie, Robert F Clark, Melissa A Troester, Susan J Sumner
Breast carcinogenesis is a multistep process accompanied by widespread molecular and genomic alterations, both in tumor and in surrounding microenvironment. It is known that tumors have altered metabolism, but the metabolic changes in normal or cancer-adjacent, nonmalignant normal tissues and how these changes relate to alterations in gene expression and histological composition are not well understood. Normal or cancer-adjacent normal breast tissues from 99 women of the Normal Breast Study (NBS) were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29667882/new-doppler-imaging-technique-for-assessing-angiogenesis-in-breast-tumors-correlation-with-immunohistochemically-analyzed-microvessels-density
#17
Sewha Kim, Hye Jin Lee, Kyung Hee Ko, Ah Young Park, Jieun Koh, Hae Kyoung Jung
Background Microvessel density (MVD) is associated with grade and prognosis in breast tumors. However, conventional color Doppler flow (CDF) imaging has been limited to represent MVD of breast tumors. Purpose To evaluate whether a new Doppler imaging technique (AngioPLUS) can represent MVD of breast tumors. Material and Methods The institutional review board approved this retrospective study, and patients' informed consent was waived. CDF and AngioPLUS were available in pathologically confirmed 55 breast tumors of 53 women...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29667880/motion-artifacts-lesion-type-and-parenchymal-enhancement-in-breast-mri-what-does-really-influence-diagnostic-accuracy
#18
Paola Clauser, Matthias Dietzel, Michael Weber, Clemens G Kaiser, Pascal At Baltzer
Background Motion artifacts can reduce image quality of breast magnetic resonance imaging (MRI). There is a lack of data regarding their effect on diagnostic estimates. Purpose To evaluate factors that potentially influence readers' diagnostic estimates in breast MRI: motion artifacts; amount of fibroglandular tissue; background parenchymal enhancement; lesion size; and lesion type. Material and Methods This Institutional Review Board-approved, retrospective, cross-sectional, single-center study included 320 patients (mean age = 55...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29667342/middle-down-characterization-of-the-cell-cycle-dependence-of-histone-h4-post-translational-modifications-and-proteoforms
#19
Tingting Jiang, Michael E Hoover, Matthew V Holt, Michael A Freitas, Alan G Marshall, Nicolas L Young
Post-translational modifications (PTMs) of histones are important epigenetic regulatory mechanisms that are often dysregulated in cancer. We employ middle-down proteomics to investigate the PTMs and proteoforms of histone H4 during cell cycle progression. We use pH gradient weak cation exchange-hydrophilic interaction liquid chromatography (WCX-HILIC) for on-line liquid chromatography-mass spectrometry analysis to separate and analyze the proteoforms of histone H4. This provides enhanced separation of proteoforms, including positional isomers, and simplifies downstream data analysis...
April 17, 2018: Proteomics
https://www.readbyqxmd.com/read/29667115/biopsy-feasibility-trial-for-breast-cancer-pathologic-complete-response-detection-after-neoadjuvant-chemotherapy-imaging-assessment-and-correlation-endpoints
#20
Gaiane M Rauch, Henry M Kuerer, Beatriz Adrada, Lumarie Santiago, Tanya Moseley, Rosalind P Candelaria, Elsa Arribas, Jia Sun, Jessica W T Leung, Savitri Krishnamurthy, Wei T Yang
PURPOSE: This study was designed to present the secondary imaging endpoints of the trial for evaluating mammogram (MMG), ultrasound (US) and image guided biopsy (IGBx) assessment of pathologic complete response (pCR) in breast cancer (BC) patients undergoing neoadjuvant chemotherapy (NAC). METHODS: Patients with T1-3, N0-3, M0 triple-negative or HER2-positive BC who received NAC were enrolled in an Institutional Review Board-approved prospective, clinical trial...
April 17, 2018: Annals of Surgical Oncology
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