keyword
MENU ▼
Read by QxMD icon Read
search

Artemisinin

keyword
https://www.readbyqxmd.com/read/29141762/efficacy-of-artemether-lumefantrine-for-uncomplicated-plasmodium-falciparum-malaria-in-cruzeiro-do-sul-brazil-2016
#1
Megumi Itoh, Suiane Negreiros do Valle, Sâmela Farias, Thayna Maria Holanda de Souza, Giselle Maria Rachid Viana, Naomi Lucchi, Stella Chenet, Paola Marchesini, Marinete Póvoa, Ana Carolina Faria E Silva Santelli, Alexandre Macedo de Oliveira
We evaluated the therapeutic efficacy of artemether-lumefantrine (AL) fixed-dose combination to treat uncomplicated Plasmodium falciparum malaria in Cruzeiro do Sul, Acre State, in the Amazon region of Brazil. Between December 2015 and May 2016, we enrolled 79 patients, 5-79 years old with fever or history of fever in the previous 48 hours and P. falciparum monoinfection confirmed by microscopy. Attempts were made to provide direct observation or phone reminders for all six doses of AL, and patients were followed-up for 28 days...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141758/in-vitro-sensitivity-of-pyronaridine-in-thai-isolates-of-plasmodium-falciparum
#2
Kittiya Mahotorn, Peerapan Tan-Ariya, Thunyapit Thita, Toon Ruang-Areerate, Naruemon Sittichot, Nantana Suwandittakul, Mathirut Mungthin
Pyronaridine, a Mannich base antimalarial agent with a high activity against chloroquine-resistant Plasmodium falciparum, has been combined with artesunate as a new artemisinin derivative-based combination therapy (ACT). Pyronaridine-artesunate combination could be one of the choices for the treatment of uncomplicated falciparum malaria in multidrug-resistant areas including Thailand. The aim of this study was to determine in vitro sensitivity and cross-resistance pattern of pyronaridine in Thai isolates of P...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29132373/understanding-malaria-treatment-seeking-preferences-within-the-public-sector-amongst-mobile-migrant-workers-in-a-malaria-elimination-scenario-a-mixed-methods-study
#3
Aung Ye Naung Win, Thae Maung Maung, Khin Thet Wai, Tin Oo, Aung Thi, Rungrawee Tipmontree, Ngamphol Soonthornworasiri, Mondha Kengganpanich, Jaranit Kaewkungwal
BACKGROUND: Migration flows and the emerging resistance to artemisinin-based combination therapy in the Greater Mekong Sub-region (GMS) create programmatic challenges to meeting the AD 2030 malaria elimination target in Myanmar. The National Malaria Control Programme (NMCP) targeted migrant workers based mainly on the stability of their worksites (categories 1: permanent work-setting; categories 2 and 3: less stable work-settings). This study aims to assess the migration patterns, malaria treatment-seeking preferences, and challenges encountered by mobile/migrant workers at remote sites in a malaria-elimination setting...
November 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29132370/expanding-malaria-diagnosis-and-treatment-in-lao-pdr-lessons-learned-from-a-public-private-mix-initiative
#4
Nouannipha Simmalavong, Sengkham Phommixay, Phoudaliphone Kongmanivong, Odai Sichanthongthip, Bouasy Hongvangthong, Deyer Gopinath, David M Sintasath
BACKGROUND: As in other countries of the Greater Mekong Sub-region (GMS), the private health sector constitutes a significant avenue where malaria services are provided and presents a unique opportunity for public-private collaboration. In September 2008, a public-private mix (PPM) strategy was launched initially in four northern and southern provinces in Lao PDR to increase access to rapid diagnostic tests (RDTs) and artemisinin-based combination therapy (ACT), improve quality of care, and collect routine malaria data from the private sector...
November 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29128848/antimalarial-activity-of-malaria-box-compounds-against-plasmodium-falciparum-clinical-isolates
#5
Jersley D Chirawurah, Felix Ansah, Prince B Nyarko, Samuel Duodu, Yaw Aniweh, Gordon A Awandare
Malaria remains a major cause of childhood deaths in resource-limited settings. In the absence of an effective vaccine, drugs and other interventions have played very significant roles in combating the scourge of malaria. The recent reports of resistance to artemisinin necessitate the need for new antimalarial drugs with novel mechanisms of action. Towards the development of new, affordable and easily accessible antimalarial drugs for endemic regions, the Medicines for Malaria Venture (MMV) assembled a total of 400 active antimalarial compounds called the Malaria Box...
October 16, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29128513/dihydroartemisinin-induced-caspase-dependent-apoptosis-through-inhibiting-the-specificity-protein-1-pathway-in-hepatocellular-carcinoma-sk-hep-1-cells
#6
Eunji Im, Changhwan Yeo, Hyo-Jeong Lee, Eun-Ok Lee
AIMS: Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin, well known for a safe and effective first-line antimalarial agent. This study investigated whether and how DHA induces apoptosis focusing on the specificity protein 1 (Sp1) pathway in hepatocellular carcinoma (HCC) SK-Hep-1 cells. MAIN METHODS: The cell viability was evaluated by MTT assay. Cell cycle analysis was performed after PI staining by flow cytometry system. Apoptosis was confirmed by DAPI staining and by detecting cytoplasmic histone-associated-DNA-fragments using a cell death detection ELISA(PLUS) kit...
November 8, 2017: Life Sciences
https://www.readbyqxmd.com/read/29127525/cellular-mechanisms-of-action-and-resistance-of-plasmodium-falciparum-to-artemisinin
#7
Papichaya Phompradit, Wanna Chaijaroenkul, Kesara Na-Bangchang
The recent reports of high failure rates and decline in in vitro sensitivity of Plasmodium falciparum to artemisinin-based combination therapies (ACTs) suggest the possibility of clinical artemisinin resistance along the Thai-Cambodian and Thai-Myanmar borders. The study investigated cellular mechanisms of action and resistance of P. falciparum to artesunate (stage specific activity, interaction with hemozoin, and anti-oxidant levels) in the two paired P. falciparum isolates (MSF046 and MSF060) collected before treatment with a 3-day artesunate-mefloquine and at the time of recrudescence...
November 10, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29127021/severe-delayed-haemolytic-anaemia-associated-with-artemether-lumefantrine-treatment-of-malaria-in-a-japanese-traveller
#8
Chihiro Hasegawa, Masaharu Kudo, Haruhiko Maruyama, Mikio Kimura
Delayed haemolytic anaemia has been reported in association with intravenous artesunate treatment in patients with severe Plasmodium falciparum malaria, and furthermore, oral artemisinin-based combination therapies including artemether-lumefantrine (AL) have also been incriminated. However, definite cases of delayed haemolytic anaemia associated with AL appear to be scarce, as reported cases were often treated concomitantly with other anti-malarials. In this study, we report a severe case of delayed haemolytic anaemia following AL alone in a Japanese traveller with severe parasitaemia caused by numerous P...
November 7, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29122736/enhanced-antimalalarial-activity-of-a-prolonged-release-in-situ-gel-of-arteether-lumefantrine-in-a-murine-model
#9
Shilpa Dawre, Sulabha Pathak, Shobhona Sharma, Padma V Devarajan
The World Health Organization (WHO) recommends artemisinin-based combination therapy (ACT) for treatment of falciparum malaria. Arteether (ART), an artemisinin derivative, is effective against Plasmodium falciparum, but it is available only as painful oily intramuscular (i.m.) injections. We formulated lyotropic liquid crystalline preconcentrates of ART and Lumefantrine (LUM) ACT with and without biodegradable polymer for antimalarial therapy. Following i.m. injection, both formed intact gels in situ due to rapid transition into liquid crystalline phase (LCP) which was confirmed by small angle neutron scattering (SANS), x-ray diffraction (XRD), polarization optical microscopy (POM) and rheological changes...
November 6, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29121061/a-randomized-double-blind-active-control-trial-to-evaluate-the-efficacy-and-safety-of-a-three-day-course-of-tafenoquine-monotherapy-for-the-treatment-of-plasmodium-vivax-malaria
#10
Mark M Fukuda, Srivicha Krudsood, Khadeeja Mohamed, Justin A Green, Sukhuma Warrasak, Harald Noedl, Ataya Euswas, Mali Ittiverakul, Nillawan Buathong, Sabaithip Sriwichai, R Scott Miller, Colin Ohrt
BACKGROUND: Tafenoquine is an investigational 8-aminoquinoline for the prevention of Plasmodium vivax relapse. Tafenoquine has a long half-life and the potential for more convenient dosing, compared with the currently recommended 14-day primaquine regimen. METHODS: This randomized, active-control, double-blind trial was conducted in Bangkok, Thailand. Seventy patients with microscopically confirmed P. vivax were randomized (2:1) to tafenoquine 400 mg once daily for 3 days or 2500 mg total dose chloroquine phosphate (1500 mg chloroquine base) given over 3 days plus primaquine 15 mg daily for 14 days...
2017: PloS One
https://www.readbyqxmd.com/read/29114376/dihydroartemisinin-induces-apoptosis-in-human-bladder-cancer-cell-lines-through-reactive-oxygen-species-mitochondrial-membrane-potential-and-cytochrome-c-pathway
#11
Farhad Poupel, Mahmoud Aghaei, Ahmad Movahedian, Seyyed Mehdi Jafari, Mohammad Keyvanloo Shahrestanaki
Background: Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin and has antiproliferative effect. However, such effects of DHA have not yet been revealed for bladder cancer cells. Methods: We used as bladder cancer cell lines to examine the effect of DHA on the cell viability, cell apoptosis, and monitoring of mitochondrial membrane potential (ΔΨm) changes. Furthermore, the effect of DHA on the reactive oxygen species (ROS) production and cytochrome c release were also detected...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29111368/discovery-of-new-antimalarial-agents-second-generation-dual-inhibitors-against-fp-2-and-pfdhfr-via-fragments-assembely
#12
Wenhua Chen, Zhenghui Huang, Wanyan Wang, Fei Mao, Longfei Guan, Yun Tang, Hualiang Jiang, Jian Li, Jin Huang, Lubin Jiang, Jin Zhu
Malaria parasites are a leading cause of worldwide mortality from infectious disease. Cysteine protease falcipain-2 (FP-2) and Plasmodium falciparum dihydrofolate reductase (PfDHFR) play vital roles, which are absolutely essential, in the parasite life cycle. In this study, based on the structures of uniform fragments of reported PfDHFR inhibitors and the first-generation dual inhibitors against FP-2 and PfDHFR, we identified a novel series of dual inhibitors through fragments assembly. Lead optimization led to the discovery of 24, which showed high potency against FP-2 (IC50 = 10...
October 16, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29110722/molecular-markers-for-artemisinin-and-partner-drug-resistance-in-natural-plasmodium-falciparum-populations-following-increased-insecticide-treated-net-coverage-along-the-slope-of-mount-cameroon-cross-sectional-study
#13
Tobias O Apinjoh, Regina N Mugri, Olivo Miotto, Hanesh F Chi, Rolland B Tata, Judith K Anchang-Kimbi, Eleanor M Fon, Delphine A Tangoh, Robert V Nyingchu, Christopher Jacob, Roberto Amato, Abdoulaye Djimde, Dominic Kwiatkowski, Eric A Achidi, Alfred Amambua-Ngwa
BACKGROUND: Drug resistance is one of the greatest challenges of malaria control programmes, with the monitoring of parasite resistance to artemisinins or to Artemisinin Combination Therapy (ACT) partner drugs critical to elimination efforts. Markers of resistance to a wide panel of antimalarials were assessed in natural parasite populations from southwestern Cameroon. METHODS: Individuals with asymptomatic parasitaemia or uncomplicated malaria were enrolled through cross-sectional surveys from May 2013 to March 2014 along the slope of mount Cameroon...
November 6, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29110709/the-prevalence-incidence-and-prevention-of-plasmodium-falciparum-infections-in-forest-rangers-in-bu-gia-map-national-park-binh-phuoc-province-vietnam-a-pilot-study
#14
Do Hung Son, Nguyen Thuy-Nhien, Lorenz von Seidlein, Truong Le Phuc-Nhi, Ngo Thi Phu, Nguyen Thi Kim Tuyen, Nguyen Huyen Tran, Nguyen Van Dung, Bui Van Quan, Nicholas P J Day, Arjen M Dondorp, Nicholas J White, Guy E Thwaites, Tran Tinh Hien
BACKGROUND: Prophylaxis for high-risk populations, such as forest workers, could be one component for malaria elimination in the Greater Mekong Sub-region. A study was conducted to assess the malaria incidence in forest rangers and the feasibility of malaria prophylaxis for rangers sleeping in forest camps. METHODS: Forest rangers deployed in the Bu Gia Map National Park, Vietnam were invited to participate in the study. Plasmodium infections were cleared using presumptive treatment, irrespective of malaria status, with a 3-day course dihydroartemisinin/piperaquine (DP) and a 14-day course of primaquine...
November 6, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29104626/artemether-suppresses-cell-proliferation-and-induces-apoptosis-in-diffuse-large-b-cell-lymphoma-cells
#15
Xinying Zhao, Xudong Guo, Wenqin Yue, Jianmin Wang, Jianmin Yang, Jie Chen
Artemether (ART), a derivative of the well-known anti-malaria drug artemisinin, demonstrates potent anti-cancer activity in various cancer cells, however its effects on lymphoma remain unknown. The present study demonstrated that ART significantly inhibited proliferation of diffuse large B cell lymphoma (DLBCL) in vivo and in vitro, and led to G0/G1 phase arrest. Mechanistic studies demonstrated that ART suppressed the expression of the cell cycle proteins cyclin dependent kinase (CDK) 2, 4, and Cyclin D1, and specifically repressed the proto-oncogene c-Myc, rather than regulating the extracellular signal-regulated kinase or protein kinase B signaling pathways (two key pathways involved in regulating cell proliferation)...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103923/artemether-does-not-turn-%C3%AE-cells-into-%C3%AE-cells
#16
Talitha van der Meulen, Sharon Lee, Els Noordeloos, Cynthia J Donaldson, Michael W Adams, Glyn M Noguchi, Alex M Mawla, Mark O Huising
Pancreatic α cells retain considerable plasticity and can, under the right circumstances, transdifferentiate into functionally mature β cells. In search of a targetable mechanistic basis, a recent paper suggested that the widely used anti-malaria drug artemether suppresses the α cell transcription factor Arx to promote transdifferentiation into β cells. However, key initial experiments in this paper were carried out in islet cell lines, and most subsequent validation experiments implied transdifferentiation without direct demonstration of α to β cell conversion...
November 1, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29099089/peroxides-with-anthelmintic-antiprotozoal-fungicidal-and-antiviral-bioactivity-properties-synthesis-and-reactions
#17
REVIEW
Vera A Vil', Ivan A Yaremenko, Alexey I Ilovaisky, Alexander O Terent'ev
The biological activity of organic peroxides is usually associated with the antimalarial properties of artemisinin and its derivatives. However, the analysis of published data indicates that organic peroxides exhibit a variety of biological activity, which is still being given insufficient attention. In the present review, we deal with natural, semi-synthetic and synthetic peroxides exhibiting anthelmintic, antiprotozoal, fungicidal, antiviral and other activities that have not been described in detail earlier...
November 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29094266/computational-analysis-of-artimisinin-derivatives-on-the-antitumor-activities
#18
Hui Liu, Xingyong Liu, Li Zhang
The study on antitumor activities of artemisinin and its derivatives has been closely focused on in recent years. Herein, 2D and 3D QSAR analysis was performed on the basis of a series of artemisinin derivatives with known bioactivities against the non-small-cell lung adenocarcinoma A549 cells. Four QSAR models were successfully established by CoMSIA, CoMFA, topomer CoMFA and HQSAR approaches with respective characteristic values q(2) = 0.567, R(2) = 0.968, ONC = 5; q(2) = 0.547, R(2) = 0.980, ONC = 7; q(2) = 0...
November 1, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29089893/artemisinin-a-panacea-eligible-for-unrestrictive-use
#19
Dong-Sheng Yuan, Yan-Ping Chen, Li-Li Tan, Shui-Qing Huang, Chang-Qing Li, Qi Wang, Qing-Ping Zeng
Although artemisinin has been used as anti-malarial drug, accumulating evidence on the extended therapeutic potential of artemisinin emerges. Apart from anti-malaria and anti-tumor, artemisinin can also exert beneficial effects on some metabolic disorders, such as obesity, diabetes, and aging-related diseases. However, whether artemisinin should be applied to treatment of the wide-spectrum diseases is debating. Here, we discuss the predisposition of a raised risk of malarial resistance to artemisinin from consideration of the multi-target and non-specific features of artemisinin...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29082025/prevalence-of-substandard-and-falsified-artemisinin-based-combination-antimalarial-medicines-on-bioko-island-equatorial-guinea
#20
Harparkash Kaur, Elizabeth Louise Allan, Ibrahim Mamadu, Zoe Hall, Michael D Green, Isabel Swamidos, Prabha Dwivedi, Maria Julia Culzoni, Facundo M Fernandez, Guillermo Garcia, Dianna Hergott, Feliciano Monti
INTRODUCTION: Poor-quality artemisinin-containing antimalarials (ACAs), including falsified and substandard formulations, pose serious health concerns in malaria endemic countries. They can harm patients, contribute to the rise in drug resistance and increase the public's mistrust of health systems. Systematic assessment of drug quality is needed to gain knowledge on the prevalence of the problem, to provide Ministries of Health with evidence on which local regulators can take action...
2017: BMJ Global Health
keyword
keyword
2337
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"