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https://www.readbyqxmd.com/read/28435397/leptin-receptor-q223r-polymorphism-in-egyptian-female-patients-with-breast-cancer
#1
Mona Abo-Bakr El-Hussiny, Mohmed Ali Atwa, Waleed Elnahas Rashad, Dalia A Shaheen, Nora Marzouk Elkady
AIM OF THE STUDY: Breast cancer is the most common cause of death in women. Obesity has been associated with increased risk of breast cancer in post-menopausal women. It induces chronic inflammation, which increases local and systemic levels of cytokines and adipokines such as leptin. Leptin (LEP) and leptin receptor (LEPR) genes have several polymorphisms in humans. This study aims to assess the association between blood levels of leptin and LEPR Q223R gene polymorphism in patients of cancer breast...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435258/quantum-dots-modulate-intracellular-ca-2-level-in-lung-epithelial-cells
#2
Huijuan Yin, Jacopo M Fontana, Johan Solandt, Johnny Israelsson Jussi, Hao Xu, Hjalmar Brismar, Ying Fu
While adverse effects of nanoparticles on lung health have previously been proposed, few studies have addressed the direct effects of nanoparticle exposure on the airway epithelium. In this work, we examine the response of the pulmonary airway to nanoparticles by measuring intracellular Ca(2+) concentration ([Ca(2+)]i) in the Calu-3 epithelial layer stimulated by 3-mercaptopropionic-acid (3MPA) coated CdSe-CdS/ZnS core-multishell quantum dots (QDs). Simultaneous transient transepithelial electrical resistance (TEER) decrease and global [Ca(2+)]i increase in Calu-3 epithelial layer, accompanied by cell displacements, contraction, and expansion, were observed under QD deposition...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28434066/toxicity-and-genotoxicity-of-three-antimicrobials-commonly-used-in-veterinary-medicine
#3
Anahí Magdaleno, Sofía Carusso, Juan Moretton
The toxicity of chlortetracycline (CTC), oxytetracycline (OTC) and enrofloxacin (ENF) was tested on two green algal species: the international standard Pseudokirchneriella subcapitata and the native Argentine species Ankistrodesmus fusiformis. All three antibiotics inhibited the algal growth. The most sensitive species was P. subcapitata, for which the EC50 for CTC, OTC and ENF were 1.19 ± 0.53, 0.92 ± 0.30 and 5.18 ± 3.80 mg L(-1), respectively. The EC50 for A. fusiformis, were 3.23 ± 0...
April 22, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28431863/the-myometrial-contractility-during-late-pregnancy-in-dairy-cows-in-vitro
#4
L Górriz-Martín, S E Ulbrich, M Schmicke, G Hirsbrunner, C Keller, N Yücesoy, C Pfarrer, H Bollwein, M Heppelmann
This study aimed to investigate the in vitro contractility of the myometrium and its relationship to the blood concentrations of estradiol-17β (E2β), progesterone (P4), 15-keto-13,14-dihydro-PGF2α (PGFM) and ionised calcium (Ca(2+)) prior to tissue harvest in 12 healthy Holstein-Friesian cows in late pregnancy. Three circular (CM) and 3 longitudinal myometrial (LM) strips were dissected during a caesarean section and mounted in an organ bath containing modified Krebs solution (KS). The spontaneous contractility was recorded during five 30-min time periods (T1 to T5), after which the strips were exposed to increasing concentrations of oxytocin (OT; 10(-10)-10(-7)M), a natural PGF2α-analogue (PGF; 10(-7)-10(-4)M) and KS (Cont) for four 30-min time periods (T6 to T9)...
April 7, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28429925/robot-assisted-laparoendoscopic-single-site-versus-mini-laparoscopic-pyeloplasty-a-comparison-of-perioperative-functional-and-cosmetic-results
#5
Cristian Fiori, Riccardo Bertolo, Matteo Manfredi, Fabrizio Mele, Daniele Amparore, Giovanni Cattaneo, Ivano Morra, Roberto M Scarpa, Francesco Porpiglia
BACKGROUND: New approaches have been developed to further reduce the invasiveness of laparoscopic pyeloplasty (P) as treatment for uretero-pelvic junction obstruction (UPJO). Aim of the study was to compare perioperative, functional and cosmetic results of mini-laparoscopic (mL-P) versus robot-assisted laparoendoscopic single-site P (rLESS-P). METHODS: Since April 2009 to June 2010, 12 adult patients with primary UPJO, BMI<25 and no previous abdominal surgeries were enrolled undergoing mLP (3-mm instruments only)...
April 20, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28427079/diagnostic-accuracy-of-combinations-of-tumor-markers-for-malignant-pleural-effusion-an-updated-meta-analysis
#6
Yuan Yang, Ya-Lan Liu, Huan-Zhong Shi
BACKGROUND: The role of combinations of tumor markers such as carcinoembryonic antigen (CEA), carbohydrate antigens (CA) 125, 15-3, and 19-9, and CYFRA 21-1 (a fragment of cytokeratin 19) in diagnosing malignant pleural effusion (MPE) has not been clearly established. OBJECTIVES: This meta-analysis was performed to establish the overall diagnostic accuracies of combinations of these pleural fluid tumor markers for MPE. METHODS: The PubMed, Ovid, Embase, Web of Science, and Cochrane bibliographic databases were searched...
April 21, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28424290/skin-derived-precursors-from-human-subjects-with-type-2-diabetes-yield-dysfunctional-vascular-smooth-muscle-cells
#7
Sarah Katherina Steinbach, Terrence M Yau, Maral Ouzounian, Husam Abdel-Qadir, Mark Chandy, Thomas Waddell, Mansoor Husain
Objective: Few methods enable molecular and cellular studies of vascular aging or type-2 diabetes (T2D). Here we report a new approach to studying human vascular smooth muscle cell (VSMC) pathophysiology by examining VSMCs differentiated from progenitors found in skin. Approach and Results: Skin-derived precursors (SKPs) were cultured from biopsies (N=164, ~1 cm(2)) taken from the edges of surgical incisions of older adults (N=158; males 72%; mean age 62.7±13 years) undergoing cardiothoracic surgery, and differentiated into VSMCs at high efficiency (>80% yield)...
April 19, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28423470/quantification-of-near-attomole-gibberellins-in-floral-organs-dissected-from-single-arabidopsis-thaliana-flower
#8
Dongmei Li, Zhenpeng Guo, Cuimei Liu, Jincheng Li, Wenzhong Xu, Yi Chen
There remains a methodological bottleneck in the quantification of ultra-trace plant hormones in very tiny plant organs at a fresh weights below milligram. The challenge becomes even more serious in the determination of endogenous gibberellins (GAs), which are a class of compounds that are difficult to separate and detect. Herein, a quantitation method by ultra-high-performance liquid chromatography-tandem mass spectrometry was developed, combined with a derivatization technique in which GAs react with N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide in ethanol...
April 19, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28422421/results-of-a-10-year-survey-of-workload-for-10-treatment-vaults-at-a-high-throughput-comprehensive-cancer-center
#9
Ziad H Saleh, Jeho Jeong, Brian Quinn, James Mechalakos, Jean St Germain, Lawrence T Dauer
The workload for shielding purposes of modern linear accelerators (linacs) consists of primary and scatter radiation which depends on the dose delivered to isocenter (cGy) and leakage radiation which depends on the monitor units (MUs). In this study, we report on the workload for 10 treatment vaults in terms of dose to isocenter (cGy), monitor units delivered (MUs), number of treatment sessions (Txs), as well as, use factors (U) and modulation factors (CI) for different treatment techniques. The survey was performed for the years between 2006 and 2015 and included 16 treatment machines which represent different generations of Varian linear accelerators (6EX, 600C, 2100C, 2100EX, and TrueBeam) operating at different electron and x-ray energies (6, 9, 12, 16 and 20 MeV electrons and, 6 and 15 MV x-rays)...
April 19, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28422200/enhancing-mri-of-liver-metastases-with-a-zwitterionized-biodegradable-dendritic-contrast-agent
#10
Xiaoxuan Zhou, Mingzhou Ye, Yuxin Han, Jianbin Tang, Yue Qian, Hongjie Hu, Youqing Shen
Metastasis is the main reason for cancer-associated mortality, and accurate diagnostic imaging of metastases is critical for the clinical administration and tailoring personalized treatments for metastatic tumors. However, magnetic resonance imaging of metastases in the liver is impeded by its low sensitivity because the currently used contrast agents accumulate in hepatocytes and Kupffer cells instead of cancer cells. Herein, a 4(th) generation zwitterionized biodegradable dendritic contrast agent (DCA) with a size of ca...
April 19, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28414565/new-regenerative-vascular-grafts-for-hemodialysis-access-evaluation-of-a-preclinical-animal-model
#11
Karen Tatiana Valencia Rivero, Juliana Jaramillo Escobar, Sergio David Galvis Forero, Maria Clara Miranda Saldaña, Rocío Del Pilar López Panqueva, Néstor Fernando Sandoval Reyes, Juan Carlos Briceño Triana
The purpose of this study was to evaluate a suitable animal model for the in vivo evaluation of patency and vascular tissue regeneration in small intestinal submucosa (SIS) vascular grafts for hemodialysis access. First, a 4-mm U-shaped SIS vascular graft was implanted between the internal carotid artery (CA) and the external jugular vein (JV) in five sheep and six swine. The U-shape grafts remained functional for 53 ± 4 days in sheep and 32 ± 2 days in swine. The sheep model presented exaggerated inflammation, so the swine model was selected for the in vivo study...
April 17, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28413751/step-by-step-design-and-synthesis-of-au-sio2-phenyl-azathiacrown-for-sers-based-specific-quantification-of-inorganic-mercury
#12
Yuchao Wu, Limin Yang, Qiuquan Wang
Direct SERS-based quantification of inorganic metal species has been a problem, because they have a small Raman cross-section or even no vibrational mode. Here, we report a new strategy for SERS-based quantification of such metal species, as exemplified by inorganic mercury (Hg(II)) in waters. Step-by-step design and synthesis from azathioethers [3, 9-dithia-6-monoazaundecane (DMA) and 3,6,12,15-tetrathia-9-monoazaheptadecane (TTM)] to an azathiacrown [7-aza-1,4,10,13-tetrathiacyclohexadecane (NS4)] demonstrate an improved S-pulling effect and size-fit specificity towards Hg(II) to form Hg-S bonds...
April 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28408008/eliciting-preferences-for-information-provision-in-newborn-bloodspot-screening-programs
#13
Stuart J Wright, Fiona Ulph, Nimarta Dharni, Katherine Payne
BACKGROUND: The national newborn bloodspot screening programs (NBSPs) are continually expanding to screen for more conditions. OBJECTIVES: To quantify parents' preferences for information and the way in which this is provided in example NBSPs. METHODS: A hybrid choice experiment, combining a conjoint analysis and a discrete choice experiment, was designed. A sample of current and future parents between the ages of 18 and 45 years was identified via an Internet panel...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28407311/biological-variability-in-serum-cortisol-concentration-post-adrenocorticotropic-hormone-stimulation-in-healthy-dogs
#14
A Gal, K Weidgraaf, J P Bowden, N Lopez-Villalobos, N J Cave, J P Chambers, F Castillo-Alcala
BACKGROUND: The ACTH stimulation has low sensitivity for the diagnosis of hypercortisolism possibly as a result of biological and analytical variability. HYPOTHESIS/OBJECTIVES: To report the components of biological and analytical variability in serum cortisol concentration post-ACTH stimulation ([cortisol]) in healthy dogs. ANIMALS: Fourteen healthy harrier hound dogs. METHODS: The data were extracted from a separate, prospective, randomized, double-blinded, controlled discovery study in which dogs treated with vehicle control and 4 different doses of cortisone acetate (CA) for 7 days had an ACTH stimulation test performed to confirm the dose-dependent effect of CA...
April 13, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28403651/phytochemical-components-total-phenol-and-mineral-contents-and-antioxidant-activity-of-six-major-medicinal-plants-from-rayen-iran
#15
Naser Boroomand, Mohammad Sadat-Hosseini, Mojtaba Moghbeli, Mostafa Farajpour
The aim of this work was to evaluate the phytochemical components, minerals, the antioxidant activity and total phenol contents of the essential oil from aerial parts of six major medicinal plants in Rayen, Iran. The plants included Ranunculus arvensis, Teucrium polium, Dracocephalum polychaetum, Kelussia odoratissima, Artemisia sieberi and Thymus kotschyanus. Total phenol content ranged from 0.03 to 0.158 mg/mL. A. sieberi showed the highest radical scavenging ability (IC50 = 94 μg/mL). The amount of minerals ranged as follows: P (0...
April 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28401436/cypress-pollinosis-from-tree-to-clinic
#16
REVIEW
Denis Charpin, Christian Pichot, Jordina Belmonte, Jean-Pierre Sutra, Jarmila Zidkova, Pascal Chanez, Youcef Shahali, Hélène Sénéchal, Pascal Poncet
Cypress (Cupressus sp.pl) is a genus within the Cupressaceae family. This family covers all of the Earth's continents except for Antarctica, and it includes about 160 species. The most important taxa for allergic diseases belong to five different genera: Cupressus, Hesperocyparis, Juniperus, Cryptomeria, and Chamaecyparis. Cupressaceae species share a common pollen type that can even include the genus Taxus (Taxaceae) when this plant is also present. As Juniperus oxycedrus pollinates in October, Cupressus sempervirens in January and February, Hesperocyparis arizonica (prev...
April 11, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28399415/nitrogen-removal-performance-and-loading-capacity-of-a-novel-single-stage-nitritation-anammox-system-with-syntrophic-micro-granules
#17
Shaopo Wang, Yuan Liu, Qigui Niu, Jiayuan Ji, Toshimasa Hojo, Yu-You Li
The operation performance of a novel micro-granule based syntrophic system of nitritation and anammox was studied by controlling the oxygen concentration and maintaining a constant temperature of 25°C. With the oxygen concentration of around 0.11 (<0.15)mg/L, the single-stage nitritation-anammox system was startup successfully at a nitrogen loading rate (NLR) of 1.5kgN/m(3)/d. The reactor was successfully operated at volumetric N loadings ranging from 0.5 to 2.5kgN/m(3)/d with a high nitrogen removal of 82%...
March 29, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28392421/phenylalanine-ammonia-lyase-from-arabidopsis-thaliana-atpal2-a-potent-enzyme-for-the-synthesis-of-non-canonical-aromatic-alpha-amino-acids-part-i-comparative-characterization-to-the-enzymes-from-petroselinum-crispum-pcpal1-and-rhodosporidium-toruloides-rtpal
#18
Alana Dreßen, Thomas Hilberath, Ursula Mackfeld, Arne Billmeier, Jens Rudat, Martina Pohl
Phenylalanine ammonia lyase (PAL) from Arabidopsis thaliana (AtPAL2) was comparatively characterized to the well-studied enzyme from parsley (PcPAL1) and Rhodosporidium toruloides (RtPAL) with respect to kinetic parameters for the deamination and the amination reaction, pH- and temperature optima and the substrate range of the amination reaction. Whereas both plant enzymes are specific for phenylalanine, the bifunctional enzyme from Rhodosporidium toruloides shows KM-values for L-Phe and L-Tyr in the same order of magnitude and, compared to both plant enzymes, a 10-15-fold higher activity...
April 6, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28383512/screening-and-analysis-of-the-marker-components-in-ganoderma-lucidum-by-hplc-and-hplc-ms-n-with-the-aid-of-chemometrics
#19
Lingfang Wu, Wenyi Liang, Wenjing Chen, Shi Li, Yaping Cui, Qi Qi, Lanzhen Zhang
Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, which is a popularly used traditional Chinese medicine for complementary cancer therapy. The present study was to establish a fingerprint evaluation system based on Similarity Analysis (SA), Cluster Analysis (CA) and Principal Component Analysis (PCA) for the identification and quality control of G. lucidum. Fifteen samples from the Chinese provinces of Hainan, Neimeng, Shangdong, Jilin, Anhui, Henan, Yunnan, Guangxi and Fujian were analyzed by HPLC-PAD and HPLC-MS(n)...
April 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28383029/genetic-mutation-and-exosome-signature-of-human-papilloma-virus-associated-oropharyngeal-cancer
#20
Anbarasu Kannan, Kate L Hertweck, Julie V Philley, Robert B Wells, Santanu Dasgupta
Human papilloma virus-16 (HPV-16) associated oropharyngeal cancer (HPVOPC) is increasing alarmingly in the United States. We performed whole genome sequencing of a 44 year old, male HPVOPC subject diagnosed with moderately differentiated tonsillar carcinoma. We identified new somatic mutation in MUC16 (A.k.a. CA-125), MUC12, MUC4, MUC6, MUC2, SIRPA, HLA-DRB1, HLA-A and HLA-B molecules. Increased protein expression of MUC16, SIRPA and decreased expression of HLA-DRB1 was further demonstrated in this HPVOPC subject and an additional set of 15 HPVOPC cases...
April 6, 2017: Scientific Reports
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