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https://www.readbyqxmd.com/read/28726073/investigation-of-heavy-metal-level-and-mineral-nutrient-status-in-widely-used-medicinal-plants-leaves-in-turkey-insights-into-health-implications
#1
Ibrahim Ilker Ozyigit, Bahattin Yalcin, Senay Turan, Ibrahim Adnan Saracoglu, Sedat Karadeniz, Ibrahim Ertugrul Yalcin, Goksel Demir
The use of plants in treatments has been as old as humanity and it has preserved its popularity for centuries til now because of their availability, affordability and safeness. However, despite their widespread use, safety and quality issues have been major concerns in the world due to industrial- and anthropogenic-based heavy metal contamination risks. Thus, this study was attempted to analyze the heavy metal levels and mineral nutrient status of widely used medicinal plants in Turkey to have insights about their health implications on humans...
July 19, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28724904/hypertonic-saline-infusion-suppresses-apoptosis-of-hippocampal-cells-in-a-rat-model-of-cardiopulmonary-resuscitation
#2
Xiang Zhou, Yong Liu, Yang Huang, ShuiBo Zhu, Jian Zhu, RongPing Wang
Hypertonic saline (HS) attenuates cerebral edema, improves microcirculation perfusion and alleviates inflammation. However, whether the beneficial effect of HS on neurological function after cardiopulmonary resuscitation (CPR) in rat model of asphyxial cardiac arrest (CA) is mediated via attenuating apoptosis of neurons is not known. We studied the neuroprotective effect of HS in rats after CA and CPR, and explored the likely underlying mechanisms. Animals were randomly assigned to 4 equal groups (n = 15 each) according to the different infusions administered during resuscitation: control (C), normal saline (NS), hypertonic saline (HS), and hydroxyethyl starch (HES) groups...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723663/a-network-meta-analysis-on-the-efficacy-of-targeted-agents-in-combination-with-chemotherapy-for-treatment-of-advanced-metastatic-triple-negative-breast-cancer
#3
Long Ge, Yan Tang, Qiu-Ning Zhang, Jin-Hui Tian, Xiao-Hu Wang, Dawid Pieper, Bei Pan, Lun Li, Juan Ling, Zhi-Tong Bing, Ke-Hu Yang
OBJECTIVE: Our network meta-analysis aimed to determine the assistant efficacy of targeted therapy in combined with chemotherapy for advanced/metastatic triple-negative breast cancer (TNBC). RESULTS: A total of 15 randomized controlled trials (RCTs), involving 2,410 patients, met our inclusion criteria. Eight targeted agents involving 11 treatment arms were included. The methodological quality of included RCTs was acceptable. The results of direct comparisons showed that progression-free survival (PFS) was significantly longer with bevacizumab+chemotherapy when compared to chemotherapy alone (hazard ratio [HR] = 0...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721612/interface-effect-of-natural-precipitated-dust-on-the-normal-flora-of-escherichia-coli-and-staphylococcus-epidermidis
#4
Jianjun Deng, Faqin Dong, Qunwei Dai, Tingting Huo, Ji Ma, Xu Zhang, Jie Yang
This study aimed to evaluate the interface effect between five types of natural precipitated dust and two normal floras. Five kinds of natural dust (FC-1(#), FC-2(#), FC-15(#), FC-18(#), and FC-21(#)) were collected, and particle size and chemical components were detected by laser particle size analyzer and X-ray fluorescence (XRF). The elements, bacterial count, glucose (GLU) consumption, pH, and three biochemical indicators were measured after being co-cultured with Escherichia coli and Staphylococcus epidermidis in vitro...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28721330/truebeam-radiosurgery-for-the-treatment-of-trigeminal-neuralgia-preliminary-results-at-a-single-institution
#5
Mena G Kerolus, Neilayan Sen, Sonal Mayekar, Alistar Templeton, Julius Turian, Aidnag Diaz, Lorenzo Munoz, Richard W Byrne, Sepehr Sani
INTRODUCTION: Radiosurgery is now an established method of satisfactory pain control in patients with trigeminal neuralgia (TN). The Varian Truebeam STx (Varian Medical Systems, Palo Alto, CA) linear accelerator (LINAC) system is an arc-based, frameless stereotactic radiosurgery system used for the treatment of TN. To our knowledge, there has been only one published series of patient histories that documents the use of a frameless LINAC system for the treatment of TN. We describe the treatment parameters, patient outcomes, and complications associated with the treatment of TN...
June 16, 2017: Curēus
https://www.readbyqxmd.com/read/28718288/iminocyclohexadienylidenes-carbenes-or-diradicals-the-hetero-wolff-rearrangement-of-benzotriazoles-to-cyanocyclopentadienes-and-1h-benzo-b-azirines
#6
Begue Didier, Hugo Santos-Silva, Alain Dargelos, Curt Wentrup
The thermal rearrangements of benzotriazole 1 to fulvenimine 4 and 1H-benzazirine 6 are investigated at DFT and CASPT2 levels of theory. Ring opening of benzotriazole 1 to 2-diazo-cyclohexadienimine 2 followed by N2 elimination affords Z- and E-2-iminocyclohexadienylidenes 3, which have triplet ground states (3A"). The open-shell singlet (OSS) (1A") and closed-shell singlet (CSS) (1A') of 3 lie ca. 15 and 40 kcal/mol higher in free energy, respectively. The OSS 3 (1A") is best described as a 1,3-diradical, whereas the CSS (1A') has the character of a carbene...
July 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28712068/qualitative-angiographic-and-quantitative-myocardial-perfusion-assessment-using-fluorescent-cardiac-imaging-during-graded-coronary-artery-bypass-stenosis
#7
Christian Detter, Detlef Russ, Jan Felix Kersten, Hermann Reichenspurner, Sabine Wipper
Intraoperative graft assessment in coronary artery bypass (CAB) grafting is important to avoid early graft failure. This study aimed to evaluate the accuracy of fluorescent cardiac imaging (FCI) for intraoperative qualitative angiographic and quantitative myocardial perfusion assessment during graded CAB stenosis compared to coronary angiography (CA). After CAB grafting to the left anterior descending coronary artery, graded distal bypass stenoses were created in ten pigs by 25, 50, 75, and 100% flow reduction assessed by transit-time flow measurement (TTFM)...
July 15, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28711430/implementation-of-a-national-bundle-care-program-to-reduce-catheter-associated-urinary-tract-infection-in-high-risk-units-of-hospitals-in-taiwan
#8
Chih-Cheng Lai, Chun-Ming Lee, Hsiu-Tzy Chiang, Ching-Tzu Hung, Ying-Chun Chen, Li-Hsiang Su, Zhi-Yuan Shi, Jein-Wei Liu, Chang-Pan Liu, Min-Chi Lu, Yin-Ching Chuang, Wen-Chien Ko, Shu-Hui Tseng, Yen-Hsu Chen, Po-Ren Hsueh
BACKGROUND/PURPOSE: This study was intended to investigate the impact of implementation of catheter-associated urinary tract infection (CA-UTI) bundle care on the incidence of CA-UTI in high-risk units. METHODS: Thirteen high-risk units, including medical (n = 5), surgical (n = 3), cardiac intensive care units (n = 2), respiratory care centers (n = 2), and respiratory care ward (n = 1) were included in this quality-improvement project. This study was divided into pre-intervention phase (from January 1 to July 31) and post-intervention phase (from August 1 to October 31) in 2013...
June 26, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28711248/the-effect-of-source-of-supplemental-dietary-calcium-and-magnesium-in-the-peripartum-period-and-level-of-dietary-magnesium-postpartum-on-mineral-status-performance-and-energy-metabolites-in-multiparous-holstein-cows
#9
B M Leno, S E LaCount, C M Ryan, D Briggs, M Crombie, T R Overton
The objective of this study was to determine the effects of feeding different supplemental sources of Ca and Mg in the peripartum period, and different dietary levels of Mg postpartum, on plasma mineral status, performance, and aspects of energy metabolism in transition dairy cows. Multiparous Holstein cows (n = 41) were used in a completely randomized design with a 2 × 2 factorial arrangement of treatments starting at 28 d before expected parturition. Main effects were source assignments (CS = common sources of supplemental Ca and Mg, or MA = a blend of common and commercial mineral sources with supplemental minerals primarily from a commercial Ca-Mg dolomite source; MIN-AD, Papillon Agricultural Company Inc...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28708677/repeated-critical-illness-and-unplanned-readmissions-within-1-year-to-picus
#10
Jeffrey D Edwards, Adam R Lucas, W John Boscardin, R Adams Dudley
OBJECTIVES: To determine the occurrence rate of unplanned readmissions to PICUs within 1 year and examine risk factors associated with repeated readmission. DESIGN: Retrospective cohort analysis. SETTING: Seventy-six North American PICUs that participated in the Virtual Pediatric Systems, LLC (VPS, LLC, Los Angeles, CA). PATIENTS: Ninety-three thousand three hundred seventy-nine PICU patients discharged between 2009 and 2010...
August 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28708225/clinical-outcomes-of-salvage-chemoradiotherapy-for-locally-recurrent-biliary-tract-cancer
#11
Jeong Il Yu, Hee Chul Park, Do Hoon Lim, Joon Oh Park, Young Suk Park, Seung Tae Kim, Seong Ho Choi, Dong Wook Choi, In Woong Han, Jin Seok Heo
PURPOSE: The purpose of this study was to investigate the clinical outcomes and prognostic factors of concurrent chemoradiotherapy (CCRT) for locally recurrent biliary tract cancer (BTC) after curative surgical resection. METHODS: We performed a retrospective cohort study of patients with locally recurrent BTC treated with CCRT between October 2004 and December 2013. The study included and analyzed 42 patients with a history of curative-intent surgical resection of confirmed adenocarcinoma originating from the biliary tract...
July 11, 2017: Tumori
https://www.readbyqxmd.com/read/28700827/compatible-rhizosphere-competent-microbial-consortium-add-value-to-nutritional-quality-in-edible-parts-of-chickpea
#12
Sudheer KUmar Yadav, Surendra Singh, Harikesh Bahadur Singh, Birinchi Kumar Sarma
Chickpea is used as a high energy and protein source in human and livestock's diets. Moreover, chickpea straw can be used as alternative of forage in ruminant diets. The present study evaluates the effect of beneficial microbial inoculation on enhancing the nutritional values in edible parts of chickpea. Two rhizosphere competent compatible microbes (Pseudomonas fluorescens OKC and Trichoderma asperellum T42) were selected and applied to seeds either individually or in consortium before sowing. Chickpea seeds treated with the microbes showed enhanced plant growth (88...
July 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28698009/a-randomised-open-label-phase-2-study-of-the-ido1-inhibitor-epacadostat-incb024360-versus-tamoxifen-as-therapy-for-biochemically-recurrent-ca-125-relapse-only-epithelial-ovarian-cancer-primary-peritoneal-carcinoma-or-fallopian-tube-cancer
#13
Rebecca Kristeleit, Irina Davidenko, Vadim Shirinkin, Fatima El-Khouly, Igor Bondarenko, Michael J Goodheart, Vera Gorbunova, Carol A Penning, Jack G Shi, Xiangdong Liu, Robert C Newton, Yufan Zhao, Janet Maleski, Lance Leopold, Russell J Schilder
OBJECTIVE: Indoleamine 2,3-dioxygenase-1 (IDO1) is a key regulator of immune tolerance in ovarian cancer. This study investigated efficacy and safety of the IDO1 enzyme inhibitor epacadostat versus tamoxifen in patients with biochemical-only recurrence (CA-125 elevation) following complete remission after first-line chemotherapy for advanced epithelial ovarian, primary peritoneal, or fallopian tube cancer. METHODS: In this open-label, phase 2 study (NCT01685255), patients were randomised 1:1 to epacadostat 600mg or tamoxifen 20mg twice daily for successive 28-day cycles and stratified by time since completion of first-line chemotherapy to first CA-125 elevation (3 to <12 or ≥12months)...
July 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28690989/the-association-between-skeletal-maturation-and-adrenal-androgen-levels-in-obese-children-and-adolescents
#14
Sung Eun Kim, Joon Weon Jang, Moon Bae Ahn, Shin-Hee Kim, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Min Ho Jung, Byoung Kyu Suh
PURPOSE: This study aimed to investigate the association between skeletal maturation and adrenal androgen levels in obese children and adolescents. METHODS: Fifty-three children and adolescents (aged 7-15 years) diagnosed as obese or overweight were investigated. Anthropometric measurements, bone age (BA) determination, serum biochemical analyses, and hormonal measurements were performed. The difference between BA and chronological age (BA-CA, dBACA) was calculated and used to represent the degree of advanced skeletal maturation...
June 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28686983/chronophysiological-features-of-the-normal-mineral-composition-of-human-saliva
#15
Lyudmila V Bel'skaya, Victor K Kosenok, Elena A Sarf
BACKGROUND: The high rate of changes in the composition of saliva can be used for the monitoring of various biorhythms in order to study the physiological characteristics of the human body. RESEARCH OBJECTIVE: The study of the dynamics of the near-24-h mineral composition of saliva in men and women. METHODS: The study involved 20 men and 20 women, age 23.1±0.9years. Saliva samples were collected every 3h during the day within 10min. The mineral composition of saliva was defined by the capillary electrophoresis technique...
June 24, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28681121/indexes-of-cerebral-autoregulation-do-not-reflect-impairment-in-syncope-insights-from-head-up-tilt-test-of-vasovagal-and-autonomic-failure-subjects
#16
Pedro Castro, João Freitas, Rosa Santos, Ronney Panerai, Elsa Azevedo
PURPOSE: The study of dynamic cerebral autoregulation (CA), which adapts cerebral blood flow to arterial blood pressure (ABP) fluctuations, has been limited in orthostatic intolerance syndromes, mainly due to its stationary prerequisites hardly to meet during maneuvers to provoke syncope itself. New techniques of continuous estimates of CA could overcome this pitfall. We aimed to evaluate CA during head-up tilt test in common conditions causing syncope. METHODS: We compared three groups: eight controls; eight patients with autonomic failure due to familial amyloidotic polyneuropathy; eight patients with vasovagal syncope (VVS)...
July 5, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28681102/four-myxobolus-spp-myxosporea-bivalvulida-from-the-gill-lamellae-of-common-carp-cyprinus-carpio-and-japanese-silver-crucian-carp-carassius-langsdorfii-in-the-western-part-of-japan-with-the-description-of-three-new-species-m-tanakai-n-sp-m-paratoyamai-n-sp-and
#17
Eigo Kato, Akihiro Kasai, Hisayuki Tomochi, Ying-Chun Li, Hiroshi Sato
Approximately three dozen Myxobolus spp. (Myxozoa: Myxosporea: Bivalvulida) have been described to parasitize the gills of carp of the genera Cyprinus and Carassius. Hitherto, these fish were often introduced to temperate waters worldwide as food and ornamental fish from Asia, their place of origin. The present study examined the myxosporean infection of seven common carp (Cyprinus carpio) and seven Japanese silver crucian carp (Carassius langsdorfii) collected from the Fushinogawa River around the university in Yamaguchi City, Japan, during the period April 2015 to October 2016...
July 5, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28678965/calcium-hydroxide-associated-with-a-new-vehicle-psidium-cattleianum-leaf-extracts-tissue-response-evaluation
#18
Diego Valentim, Carlos Roberto Emerenciano Bueno, Vanessa Abreu Sanches Marques, Ana Maria Veiga Vasques, Marina Tolomei Sandoval Cury, Luciano Tavares Angelo Cintra, Eloi Dezan
The aim of this study was to evaluate edemogenic activity and subcutaneous inflammatory reaction induced by Psidium cattleianum leaf extracts associated with Ca(OH)2. Thirty male Wistar rats, split equally into three groups [aqueous extract + Ca(OH)2; ethanolic extract + Ca(OH)2; and propylene glycol + Ca(OH)2], were assessed every 3 h or 6 h (five animals in each period). Under general anesthesia, 0.2 mL of 1% Evans blue per 100 g of body weight was injected into the penile vein and each combination to be evaluated was subcutaneously injected into the dorsal region 30 min thereafter...
July 3, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28674624/left-atrial-strain-predicts-recurrence-of-atrial-arrhythmias-after-catheter-ablation-of-persistent-atrial-fibrillation
#19
Abdul Shokor Parwani, Daniel-Armando Morris, Florian Blaschke, Martin Huemer, Burkert Pieske, Wilhelm Haverkamp, Leif-Hendrik Boldt
INTRODUCTION: Success rates of catheter ablation (CA) of persistent atrial fibrillation (AF) are very variable. Identifying patients in whom sinus rhythm maintenance cannot be achieved after CA is a critical issue. METHODS: 2D speckle-tracking echocardiography was performed before the first CA procedure in consecutive patients with persistent AF. Left atrial (LA) strain was correlated with recurrence of atrial arrhythmias during the follow-up period of 15 months after one CA procedure with or without antiarrhythmic drugs (primary endpoint)...
2017: Open Heart
https://www.readbyqxmd.com/read/28672207/removal-of-disinfection-byproduct-dbp-precursors-in-water-by-two-stage-biofiltration-treatment
#20
Jie Fu, Wan-Ning Lee, Clark Coleman, Kirk Nowack, Jason Carter, Ching-Hua Huang
The removal of precursors of 36 disinfection byproducts (DBPs) in effluents from flocculation/sedimentation process was evaluated across a pilot-scale two-stage biofiltration process, i.e., a sand/anthracite (SA) biofilter (empty bed contact time (EBCT) of 7.5 min) coupled with a biologically-active granular activated carbon (GAC) contactor (EBCT of 15 min). The biofiltration process exhibited a good capacity for removal of the total DBP formation potential (DBPFP) (by 25.90 ± 2.63%), and GAC contactors contributed most to the DBPFP removal (accounting for 60...
June 27, 2017: Water Research
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