keyword
MENU ▼
Read by QxMD icon Read
search

CA 15-3

keyword
https://www.readbyqxmd.com/read/28644407/cotton-ascorbate-oxidase-promotes-cell-growth-in-cultured-tobacco-bright-yellow-2-cells-through-generation-of-apoplast-oxidation
#1
Rong Li, Shan Xin, Chengcheng Tao, Xiang Jin, Hongbin Li
Ascorbate oxidase (AO) plays an important role in cell growth through the modulation of reduction/oxidation (redox) control of the apoplast. Here, a cotton (Gossypium hirsutum) apoplastic ascorbate oxidase gene (GhAO1) was obtained from fast elongating fiber tissues. GhAO1 belongs to the multicopper oxidase (MCO) family and includes a signal peptide and several transmembrane regions. Analyses of quantitative real-time polymerase chain reaction (QRT-PCR) and enzyme activity showed that GhAO1 was expressed abundantly in 15-day post-anthesis (dpa) wild-type (WT) fibers in comparison with fuzzless-lintless (fl) mutant ovules...
June 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28639659/hydrothermal-and-biomineralization-synthesis-of-a-dual-modal-nanoprobe-for-targeted-near-infrared-persistent-luminescence-and-magnetic-resonance-imaging
#2
Yu Wang, Cheng-Xiong Yang, Xiu-Ping Yan
The development of the multimodal probes is of great importance for bioimaging application. Herein, we report the fabrication of a functional nanocomposite from near-infrared (NIR) persistent luminescent nanoparticles (PLNPs) and Gd2O3 as a multimodal probe for in vivo NIR persistent luminescence and magnetic resonance (MR) imaging. Small-sized monodispersed NIR ZnGa2O4:Cr(3+) PLNPs (ca. 15 nm) were prepared as the NIR persistent luminescence source by a hydrothermal method while hyaluronic acid (HA) functionalized Gd2O3 (HA-Gd2O3) was synthesized as the MR contrast agent via a biomineralization approach...
June 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28622320/a-novel-graft-option-after-pterygium-excision-platelet-rich-fibrin-for-conjunctivoplasty
#3
H B Cakmak, G Dereli Can, M E Can, N Cagil
PurposeTo compare the surgical results, complications, and recurrence rates of primary pterygium excision with conjunctival autografts (CA) vs platelet-rich fibrin (PRF) grafts.Patients and methodsA total of 35 eyes of 35 patients with primary pterygium were included in the study. The patients underwent excision of pterygium followed by closure of the bare sclera by CA (group 1, n=20) vs PRF grafts (group 2, n=15). The PRF was generated from the patients' own whole-blood sample by centrifugation and pressing...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28621371/does-z-equal-1-or-2-enhanced-powder-nmr-crystallography-verification-of-a-disordered-room-temperature-crystal-structure-of-a-p38-inhibitor-for-chronic-obstructive-pulmonary-disease
#4
Cory M Widdifield, Sten O Nilsson Lill, Anders Broo, Maria Lindkvist, Anna Pettersen, Anna Svensk Ankarberg, Peter Aldred, Staffan Schantz, Lyndon Emsley
The crystal structure of the Form A polymorph of N-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-pyrazin-1-yl]benzamide (i.e., AZD7624), determined using single-crystal X-ray diffraction (scXRD) at 100 K, contains two molecules in the asymmetric unit (Z' = 2) and has regions of local static disorder. This substance has been in phase IIa drug development trials for the treatment of chronic obstructive pulmonary disease, a disease which affects over 300 million people and contributes to nearly 3 million deaths annually...
June 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28607047/numbers-of-presynaptic-ca-2-channel-clusters-match-those-of-functionally-defined-vesicular-docking-sites-in-single-central-synapses
#5
Takafumi Miki, Walter A Kaufmann, Gerardo Malagon, Laura Gomez, Katsuhiko Tabuchi, Masahiko Watanabe, Ryuichi Shigemoto, Alain Marty
Many central synapses contain a single presynaptic active zone and a single postsynaptic density. Vesicular release statistics at such "simple synapses" indicate that they contain a small complement of docking sites where vesicles repetitively dock and fuse. In this work, we investigate functional and morphological aspects of docking sites at simple synapses made between cerebellar parallel fibers and molecular layer interneurons. Using immunogold labeling of SDS-treated freeze-fracture replicas, we find that Cav2...
June 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28603044/relaxation-of-isolated-guinea-pig-trachea-by-apigenin-a-constituent-of-celery-via-inhibition-of-phosphodiesterase
#6
Junn-Lain Chen, Wun-Chang Ko
Apigenin, was reported to have vasodilatory effects by inhibiting Ca(2+) influx through both voltage- and receptor-operated calcium channels, but not by inhibiting cAMP- or cGMP-phosphodiesterases (PDEs) in rat thoracic aorta. However, apigenin was reported to inhibit PDE1, 2 and 3 in guinea-pig lung and heart. The aim of this study was to clarify that guinea-pig tracheal relaxation by apigenin whether via PDE inhibition. We isometrically recorded the tension of isolated guinea-pig tracheal segments on a polygraph...
June 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28602653/infrasonic-and-ultrasonic-hearing-evolved-after-the-emergence-of-modern-whales
#7
Mickaël J Mourlam, Maeva J Orliac
Mysticeti (baleen whales) and Odontoceti (toothed whales) today greatly differ in their hearing abilities: Mysticeti are presumed to be sensitive to infrasonic noises [1-3], whereas Odontoceti are sensitive to ultrasonic sounds [4-6]. Two competing hypotheses exist regarding the attainment of hearing abilities in modern whales: ancestral low-frequency sensitivity [7-13] or ancestral high-frequency sensitivity [14, 15]. The significance of these evolutionary scenarios is limited by the undersampling of both early-diverging cetaceans (archaeocetes) and terrestrial hoofed relatives of cetaceans (non-cetacean artiodactyls)...
June 19, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28602184/nucleobase-chemosensor-based-on-carbon-nanodots
#8
Yu Hou, Xue Liu, Xiuping Tang, Tianze Li, Qiuhua Wu, Yuchun Jiang, Jie Yi, Guolin Zhang
A facile and sensitive fluorescence protocol for nucleobase detection was developed based on carbon nanodot (CD) chemosensors. The novel fluorescent CDs were prepared using four kinds of nucleobases (including adenine, guanine, thymine and cytosine) as separate carbon sources via simple hydrothermal strategy. The quantum yield of adenine CDs (A-CDs), guanine CDs (G-CDs), thymine CDs (T-CDs) and cytosine CDs (C-CDs) was checked as 15.1%, 28.3%, 10.6% and 11.7%, respectively. Four CDs can recognize their complementary nucleobases based on the principle of complementary base pairing...
October 1, 2017: Talanta
https://www.readbyqxmd.com/read/28600108/comparative-incidence-of-patellofemoral-complications-between-2-total-knee-arthroplasty-systems-in-a-multicenter-prospective-clinical%C3%A2-study
#9
Sean D Toomey, Juan A Daccach, Jinesh C Shah, Sam E Himden, James P Lesko, William G Hamilton
BACKGROUND: Cumulative incidence rates (CIRs) of patellofemoral complications (PCCs) and patellofemoral symptomatic crepitus (SC) using a new knee system-total knee arthroplasty (NEW-TKA) were compared with those of a currently available product-total knee arthroplasty (CA-TKA). METHODS: Twenty-two investigators prospectively enrolled 704 patients into a study using CA-TKA; 364 received a posterior-stabilized configuration. Twenty-three investigators (19 from the CA-TKA study) enrolled 1138 patients with NEW-TKA; 584 received a posterior-stabilized configuration...
April 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28581334/heat-tolerances-of-salmonella-cronobacter-sakazakii-and-pediococcus-acidilactici-inoculated-into-galactooligosaccharide
#10
Jihyun Bang, Moonkak Choi, Haeseok Jeong, Sangseob Lee, Yoonbin Kim, Jee-Hoon Ryu, Hoikyung Kim
Food-grade galactooligosaccharide (GOS) with low water activity (aw of ca. 0.7) is used as an ingredient in various foods. We evaluated heat tolerances of Salmonella, Cronobacter sakazakii, and Pediococcus acidilactici at temperatures (70 to 85°C) used during the saturation process of GOS by comparing decimal reduction time (D-values) and thermal resistance constants (z-values). To determine the D- and z-values, GOS containing Salmonella (5.1 to 5.8 log CFU/g) or C. sakazakii (5.3 to 5.9 log CFU/g) was heat treated at 70, 77...
June 3, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28577969/lipid-alginate-nanoparticle-loaded-in-situ-gelling-system-tailored-for-dexamethasone-nasal-delivery
#11
Bisera Jurišić Dukovski, Ivana Plantić, Ivan Čunčić, Iva Krtalić, Marina Juretić, Ivan Pepić, Jasmina Lovrić, Anita Hafner
In this study, we suggest the development of nanoparticle loaded in situ gelling system suitable for corticosteroid nasal delivery. We propose lipid/alginate nanoparticles (size 252.3±2.4nm, polydispersity index 0.241, zeta-potential -31.7±1.0mV, dexamethasone (Dex) content 255±7μgml(-1)) dispersed in pectin solution (5mgml(-1)) that undergoes a sol-gel phase transition triggered by Ca(2+) present in nasal mucosa. The viscoelasticity of gel obtained by mixing nanoparticle suspension in pectin continuous phase with simulated nasal fluid (1:1V/V) is characterized by a log-linear shear thinning viscosity behaviour...
May 31, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28574851/crgd-installed-docetaxel-loaded-mertansine-prodrug-micelles-redox-triggered-ratiometric-dual-drug-release-and-targeted-synergistic-treatment-of-b16f10-melanoma
#12
Ping Zhong, Min Qiu, Jian Zhang, Huanli Sun, Ru Cheng, Chao Deng, Fenghua Meng, Zhiyuan Zhong
The combinatorial chemotherapy that has emerged as a promising treatment modality for intractable cancers is challenged by lack of tumor-targeting, robust and ratiometric dual drug release systems. Here, docetaxel-loaded cRGD peptide-decorated redox-activable micellar mertansine prodrug (DTX-cRGD-MMP) was developed for targeted and synergistic treatment of B16F10 melanoma-bearing C57BL/6 mice. DTX-cRGD-MMP exhibited a small size of ca. 49 nm, high DTX and DM1 loading, low drug leakage under physiological conditions, while rapid release of both DTX and DM1 under a cytoplasmic reductive environment...
June 2, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28573794/possible-involvement-of-the-cacna1e-gene-in-migraine-a-search-for-single-nucleotide-polymorphism-in-different-clinical-phenotypes
#13
Anna Ambrosini, Mara D'Onofrio, Maria Gabriella Buzzi, Ivan Arisi, Gaetano S Grieco, Francesco Pierelli, Filippo M Santorelli, Jean Schoenen
OBJECTIVE: To search for differences in prevalence of a CACNA1E variant between migraine without aura, various phenotypes of migraine with aura, and healthy controls. BACKGROUND: Familial hemiplegic migraine type 1 (FHM1) is associated with mutations in the CACNA1A gene coding for the alpha 1A (Cav 2.1) pore-forming subunit of P/Q voltage-dependent Ca(2+) channels. These mutations are not found in the common forms of migraine with or without aura. The alpha 1E subunit (Cav 2...
June 1, 2017: Headache
https://www.readbyqxmd.com/read/28573447/identifying-long-term-survivors-among-metastatic-breast-cancer-patients-undergoing-primary-tumor-surgery
#14
Tae-Kyung Yoo, Byung Joo Chae, Sei Joong Kim, JungSun Lee, Tae In Yoon, Soo Jung Lee, Ho Yong Park, Heung Kyu Park, Yong Hwa Eom, Hyung Suk Kim, Chang Jong Kim, Man Sik Shin, Sun Hyong You, Byung Joo Song
PURPOSE: The prognostic role of primary tumor surgery in women with metastatic breast cancer at diagnosis is contentious. A subset of patients who will benefit from aggressive local treatment is needed to be identified. Using a nationwide database, we developed and validated a predictive model to identify long-term survivors among patients who had undergone primary tumor surgery. METHODS: A total of 150,043 patients were enrolled in the Korean Breast Cancer Registry between January 1990 and December 2014...
June 1, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28567421/effects-of-diode-laser-gaseous-ozone-and-medical-dressings-on-enterococcus-faecalis-biofilms-in-the-root-canal-ex-vivo
#15
Kerstin Bitter, Alexander Vlassakidis, Mediha Niepel, Daniela Hoedke, Julia Schulze, Konrad Neumann, Annette Moter, Jörn Noetzel
The objective was to compare the antibacterial effects of adjunctive disinfection using diode laser and gaseous ozone compared to the medical dressings calcium hydroxide (Ca(OH)2) and chlorhexidine gel (CHX-Gel) on Enterococcus faecalis biofilms in human root canals ex vivo. Root canals of 180 human extracted teeth were infected by E. faecalis and divided into 3 main groups (G): G1, control; G2, instrumentation and irrigation using 0.9% NaCl; G3, instrumentation and irrigation using 1% NaOCl. In each main group, the following treatments were applied: gaseous ozone, diode laser, and medical dressings of Ca(OH)2 or CHX-Gel for 7 days (n = 15)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28562475/duration-of-untreated-cardiac-arrest-and-clinical-relevance-of-animal-experiments-the-relationship-between-the-no-flow-duration-and-the-severity-of-post-cardiac-arrest-syndrome-in-a-porcine-model
#16
Gioanni Babini, Luigi Grassi, Ilaria Russo, Deborah Novelli, Antonio Boccardo, Anita Luciani, Francesca Fumagalli, Lidia Staszewsky, Fabio Fiordaliso, Marcella De Maglie, Monica Salio, Davide Danilo Zani, Teresa Letizia, Serge Masson, Mario Vittorio Luini, Davide Pravettoni, Eugenio Scanziani, Roberto Latini, Giuseppe Ristagno
INTRODUCTION: The study investigated the effect of untreated cardiac arrest (CA), i.e. "no-flow" time, on post-resuscitation myocardial and neurological injury, and survival in a pig model to identify an optimal duration that adequately reflects the most frequent clinical scenario. METHODS: An established model of myocardial infarction followed by CA and cardiopulmonary resuscitation was used. Twenty-two pigs were subjected to 3 no-flow durations: short (8-10 min); intermediate (12-13 min); and long (14-15 min)...
May 30, 2017: Shock
https://www.readbyqxmd.com/read/28559974/melatonin-prevents-sleep-deprivation-associated-anxiety-like-behavior-in-rats-role-of-oxidative-stress-and-balance-between-gabaergic-and-glutamatergic-transmission
#17
Lei Zhang, Hong-Liang Guo, Hu-Qin Zhang, Tian-Qi Xu, Bing He, Zhen-Hai Wang, Yi-Peng Yang, Xiao-Dan Tang, Peng Zhang, Fang-E Liu
Sleep deprivation (SD) has been shown to induce anxiety-like behavior. Melatonin, an endogenous potent antioxidant, protects neurons from oxidative stress in many disease models. Here we investigated the effect of melatonin against SD-induced anxiety-like behavior and attempted to define the possible mechanisms involved. SD was induced in rats using modified multiple platform model. Melatonin (15 mg/kg) was administered to the rats via intraperitoneal injection. The elevated plus maze test, open field test and light-dark exploration were used to evaluate anxiety-like behavior...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28558826/critical-care-at-the-end-of-life-a-population-level-cohort-study-of-cost-and-outcomes
#18
Dipayan Chaudhuri, Peter Tanuseputro, Brent Herritt, Gianni D'Egidio, Mathieu Chalifoux, Kwadwo Kyeremanteng
BACKGROUND: Despite the high cost associated with ICU use at the end of life, very little is known at a population level about the characteristics of users and their end of life experience. In this study, our goal was to characterize decedents who received intensive care near the end of life and examine their overall health care use prior to death. METHODS: This was a retrospective cohort study that examined all deaths in a 3-year period from April 2010 to March 2013 in Ontario, Canada...
May 31, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28556812/ultrafine-particle-distribution-and-chemical-composition-assessment-during-military-operative-trainings
#19
Marcello Campagna, Ilaria Pilia, Gabriele Marcias, Andrea Frattolillo, Sergio Pili, Manuele Bernabei, Ernesto d'Aloja, Pierluigi Cocco, Giorgio Buonanno
(1) Background: The assessment of airborne particulate matter (PM) and ultrafine particles (UFPs) in battlefield scenarios is a topic of particular concern; (2) Methods: Size distribution, concentration, and chemical composition of UFPs during operative military training activities (target drone launches, ammunition blasting, and inert bomb impact) were investigated using an electric low-pressure impactor (ELPI+) and a scanning electron microscope (SEM), equipped with energy-dispersive spectroscopy (EDS); (3) Results: The median of UFPs, measured for all sampling periods and at variable distance from sources, was between 1...
May 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28551359/previous-radiotherapy-and-the-clinical-activity-and-toxicity-of-pembrolizumab-in-the-treatment-of-non-small-cell-lung-cancer-a-secondary-analysis-of-the-keynote-001-phase-1-trial
#20
Narek Shaverdian, Aaron E Lisberg, Krikor Bornazyan, Darlene Veruttipong, Jonathan W Goldman, Silvia C Formenti, Edward B Garon, Percy Lee
BACKGROUND: Preclinical studies have found radiotherapy enhances antitumour immune responses. We aimed to assess disease control and pulmonary toxicity in patients who previously received radiotherapy for non-small-cell lung cancer (NSCLC) before receiving pembrolizumab. METHODS: We assessed patients with advanced NSCLC treated on the phase 1 KEYNOTE-001 trial at a single institution (University of California, Los Angeles, CA, USA). Patients were aged 18 years or older, had an Eastern Cooperative Oncology Group performance status of 1 or less, had adequate organ function, and no history of pneumonitis...
May 24, 2017: Lancet Oncology
keyword
keyword
23369
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"