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https://www.readbyqxmd.com/read/29775157/blood-based-biomarkers-in-breast-cancer-from-proteins-to-circulating-tumor-cells-to-circulating-tumor-dna
#1
Michael J Duffy, Enda W McDermott, John Crown
Biomarkers are the key to personalized treatment in patients with breast cancer. While tissue biomarkers are most useful in determining prognosis and upfront predicting response to therapy, circulating protein biomarkers such as CA 15-3 and carcinoembryonic antigen are mainly used in monitoring response to endocrine or chemotherapy in patients with advanced disease. Although several centers measure biomarkers in asymptomatic patients following curative surgery for primary breast cancer, the clinical utility of this practice is unclear...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29774558/clinical-outcome-and-comparison-of-three-different-left-ventricular-assist-devices-in-a-high-risk-cohort
#2
Konstantin Zhigalov, Ahmed Mashhour, Marcin Szczechowicz, Sabreen Mkalaluh, Sergei Karagezian, Irakli Gogia, Maxim Isaev, Bakitbek K Kadyraliev, Jerry Easo, Juergen Ennker, Harald C Eichstaedt, Alexander Weymann
We present a comparison between three left ventricular assist devices (LVADs): HeartWare (HVAD) (HeartWare International Inc., Framingham, MA, USA), HeartMate II (HMII) and HeartMate III (HMIII) (Thoratec Corp., Pleasanton, CA, USA). To our knowledge, no study to date has aimed at placing these three devices in juxtaposition. Between June 2007 and June 2017, 108 consecutive patients received HMII, n = 77 (71.3%), HVAD, n = 14 (13%), or HM III, n = 17 (15.7%), for end-stage heart failure. Mean age was 63...
May 17, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29770407/-two-in-one-organic-inorganic-hybrid-mn-ii-complexes-exhibiting-dual-emissive-phosphorescence
#3
Alexey S Berezin, Denis G Samsonenko, Valery K Brel, Alexander V Artem'ev
Unprecedented organic-inorganic hybrid complexes, [Mn(L)3]MnHal4, containing both four- and hexacoordinated Mn2+ ions were synthesized by reacting MnCl2 or MnBr2 with bis(phosphine oxide) ligands (L) such as dppmO2, dppeO2, and 2,3-bis(diphenylphosphinyl)-1,3-butadiene (dppbO2). In the [Mn(L)3]2+ cation of the complexes, the Mn2+ ion features a [MnO6] octahedral coordination environment (Oh), and the [MnHal4]2- anion adopts a tetrahedral geometry (Td). These "two-in-one" complexes exhibit strong long-lived luminescence (τav = 12-15 ms at 300 K) having interesting thermochromic behavior attributed to the thermal equilibrium between two emission bands...
May 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29763980/arterial-stiffness-in-people-with-type-2-diabetes-and-obstructive-sleep-apnoea
#4
M Hvelplund Kristiansen, A M Banghøj, E Laugesen, L Tarnow
AIMS: To examine whether people with Type 2 diabetes with concurrent obstructive sleep apnoea have increased arterial stiffness as compared with people with Type 2 diabetes without obstructive sleep apnoea. METHODS: In a study with a case-control design, 40 people with Type 2 diabetes and treatment-naïve moderate to severe obstructive sleep apnoea (Apnoea-Hypopnoea Index ≥15) and a control group of 31 people with Type 2 diabetes without obstructive sleep apnoea (Apnoea-Hypopnoea Index <5) were examined...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29762674/available-energy-and-amino-acid-digestibility-of-defatted-rice-bran-fed-to-growing-pigs
#5
B B Huang, C F Huang, Z Q Lyu, Y F Chen, P L Li, L Liu, C H Lai
This study was conducted to determine and compare available energy and apparent ileal digestibility (AID) and standardized ileal digestibility (SID) of CP and AA in 9 samples of defatted rice bran (DFRB) fed to growing pigs and to generate prediction equations for DE and ME based on chemical analysis. In Exp. 1, sixty crossbred growing pigs (Duroc × Landrace × Yorkshire; 40.7 ± 3.5 kg BW) were fed 1 of 10 diets in a completely randomized design to determine the available energy of DFRB. The diets included a corn-soybean meal basal diet and 9 experimental diets formulated by replacing the corn and soybean meal with 29...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29761912/proteinase-pattern-of-honeybee-prepupae-from-healthy-and-american-foulbrood-infected-bees-investigated-by-zymography-the-numbered-spots-figure-4-were-excised-from-the-gels-and-they-were-individually-transferred-to-a-1-5-ml-microcentrifuge-tube-spots-were-destained
#6
Proteinase pattern of honeybee prepupae from healthy and American Foulbrood infected bees investigated by zymography: The numbered spots (figure 4) were excised from the gels and they were individually transferred to a 1.5 mL microcentrifuge tube. Spots were destained and proteins digested as reported by Dani et al. 40. Each peptide mixture was submitted to capillary-LC-μESI-MS/MS analysis on an Ultimate 3000 HPLC (Dionex, San Donato Milanese, Milano, Italy) coupled to a LTQ Orbitrap mass spectrometer (Thermo Fisher, Bremen, Germany). Peptides were concentrated on a precolumn cartridge PepMap100 C18 (300 μm i.d. × 5 mm, 5 μm, 100 Å, LC Packings Dionex) and then eluted on a homemade capillary column packed with Aeris Peptide XB-C18 phase (180 μm i.d. × 15 cm, 3.6 μm, 100 Å, Phenomenex, Torrance, CA, USA) at 1 μl/min. The loading mobile phases were: 0.1% TFA in H 2 O (phase A) and 0.1% TFA in CH 3 CN (phase B). The elution mobile phases composition was: H 2 O 0.1% formic acid/CH 3 CN 97/3 (phase A) and CH 3 CN 0.1% formic acid/ H 2 O 97/3 (phase B). The elution program was: 0 min, 4% B; 10 min, 40% B; 30 min, 65% B; 35 min, 65% B; 36 min, 90% B; 40 min, 90% B; 41 min, 4%B; 60 min, 4% B. Mass spectra were acquired in positive ion mode, setting the spray voltage at 1.8 kV, the capillary voltage and temperature respectively at 45 V and 200°C, and the tube lens at 130 V. Data were acquired in data-dependent mode with dynamic exclusion enabled (repeat count 2, repeat duration 15 s, exclusion duration 30 s); survey MS scans were recorded in the Orbitrap analyzer in the mass range 300-2000 m/z at a 15,000 nominal resolution at m/z = 400; then up to three most intense ions in each full MS scan were fragmented (isolation width 3 m/z, normalized collision energy 30) and analyzed in the IT analyzer. Monocharged ions did not trigger MS/MS experiments.
Antonio Felicioli, Barbara Turchi, Filippo Fratini, Matteo Giusti, Roberta Nuvoloni, Francesca Romana Dani, Simona Sagona
American foulbrood disease (AFB) is the main devastating disease that affects honeybees' brood, caused by Paenibacillus larvae. The trend of the research on AFB has addressed the mechanisms by which P. larvae bacteria kill honeybee larvae. Since prepupae could react to the infection of AFB by increasing protease synthesis, the aim of this work was to compare protease activity in worker prepupae belonging to healthy colonies and to colonies affected by AFB. This investigation was performed by zymography. In gel, proteolytic activity was observed in prepupae extracts belonging to the healthy colonies...
May 15, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29760546/thiopurines-are-negatively-associated-with-anthropometric-parameters-in-pediatric-crohn-s-disease
#7
Neera Gupta, Robert H Lustig, Cewin Chao, Eric Vittinghoff, Howard Andrews, Cheng-Shiun Leu
AIM: To determine the distribution of anthropometric parameter (AP)- z -scores and characterize associations between medications/serum biomarkers and AP- z -scores in pediatric Crohn's disease (CD). METHODS: CD patients [< chronological age (CA) 21 years] were enrolled in a cross-sectional study. Descriptive statistics were generated for participants' demographic characteristics and key variables of interest. Paired t -tests were used to compare AP- z -scores calculated based on CA (CA z -scores) and bone age (BA) (BA z -scores) for interpretation of AP's...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29759249/in-line-carbon-nanofiber-reinforced-hollow-fiber-mediated-liquid-phase-microextraction-using-a-3d-printed-extraction-platform-as-a-front-end-to-liquid-chromatography-for-automatic-sample-preparation-and-analysis-a-proof-of-concept-study
#8
Chanatda Worawit, David J Cocovi-Solberg, Pakorn Varanusupakul, Manuel Miró
A novel concept for automation of nanostructured hollow-fiber supported microextraction, combining the principles of liquid-phase microextraction (LPME) and sorbent microextraction synergically, using mesofluidic platforms is proposed herein for the first time, and demonstrated with the determination of acidic drugs (namely, ketoprofen, ibuprofen, diclofenac and naproxen) in urine as a proof-of-concept applicability. Dispersed carbon nanofibers (CNF) are immobilized in the pores of a single-stranded polypropylene hollow fiber (CNF@HF) membrane, which is thereafter accommodated in a stereolithographic 3D-printed extraction chamber without glued components for ease of assembly...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29756775/heterogeneous-interaction-of-various-natural-dust-samples-with-isopropanol-as-a-probe-voc
#9
Mohamad Nour Zeineddine, Manolis N Romanias, Véronique Riffault, Frederic Thevenet
The adsorption properties of mineral dust toward organic molecules are poorly characterized so far. Heterogeneous processes between trace gases and mineral particles can affect the oxidative capacity of the atmosphere as well as constitute additional sources or sinks for these species. The current study investigates the adsorption efficiencies of natural dust samples collected from North and West Africa, Saudi Arabia, and Arizona desert regions toward isopropanol (IPA), a common organic pollutant released in significant amounts in the atmosphere, and used here as a probe molecule...
May 14, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29754284/determination-of-seasonal-vitamin-and-mineral-contents-of-sea-bream-sparus-aurata-l-1758-cultured-in-net-cages-in-central-black-sea-region
#10
Dilara Kaya Öztürk, Birol Baki, İsmihan Karayücel, Recep Öztürk, Gülşen Uzun Gören, Sedat Karayücel
This study aimed to determine the seasonal vitamin and mineral contents of sea bream (Sparus aurata) cultured in net cages in Central Black Sea region. The average seasonal A, D3 , and E vitamins values in fish meat were between 0.27 ± 0.02-0.60 ± 0.00, 0.98 ± 0.01-1.70 ± 0.00, and 3.10 ± 0.14-6.00 ± 0.21 mg/kg, respectively (p < 0.05). The average seasonal Ca, Fe, K, Mg, Na, P, Zn, and Se values in fish meat were between 276.90 ± 0.99-1788.50 ± 51.27 (p < 0...
May 12, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29746985/theoretical-personalized-optimum-chest-compression-point-can-be-determined-using-posteroanterior-chest-radiography
#11
Sunho Cho, Won Sup Oh, Sung-Bin Chon, Shinwoo Kim, Keunha Hwang
AIM: Cardiopulmonary resuscitation guidelines suggest the lower sternal half be compressed. However, stroke volume has been assumed to be maximized by compressing the 'point' (P_max.LV) beneath which the left ventricle (LV) is at its maximum diameter. Identifying 'personalized' P_max.LV on computed tomography (CT), we derived and validated rules to estimate P_max.LV using posteroanterior chest radiography (chest_PA). METHODS: A retrospective, cross-sectional study was performed with non-cardiac arrest (CA) adults who underwent chest_PA and CT within 1h (derivation:validation = 3:2)...
May 7, 2018: Resuscitation
https://www.readbyqxmd.com/read/29745746/ca-15-3-predicting-breast-cancer-relapse-beware-of-vitamin-b12-deficiency
#12
Elie El Rassy, Maya Al Ghor, Joseph Kattan
A sustained increase of cancer antigen 15-3 serum levels was found in a 54-year-old woman treated 2 years ago for early stage breast cancer, without any evidence of cancer recurrence. The patient thereafter developed severe megaloblastic anemia secondary to vitamin B12 deficiency. Supplementation with B12 to reverse the anemia led to the normalization of the cancer antigen 15-3 serum levels. As such, with the limited understanding of molecular biology, the integrative approach of clinical history, physical examination, and diagnostic imaging remain pivotal in the management of cancer patients...
May 10, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29744622/lethal-and-sublethal-responses-in-the-fish-odontesthes-bonariensis-exposed-to-chlorpyrifos-alone-or-under-mixtures-with-endosulf%C3%A3-n-and-lambda-cyhalothrin
#13
Viviana López Aca, Patricia Verónica Gonzalez, Pedro Carriquiriborde
Need for ecotoxicological information on local species has been recently highlighted as a priority issue in Latin America. In addition, little information has been found on concentration distances between lethal and sublethal effects, and the effect of mixtures at these two levels of analysis. Chlorpyrifos (CPF) is an organophosphate insecticide broadly used in soybean crops which has dramatically expanded in Latin America and other regions of the world. The aim of the present study was to evaluate lethal and sublethal effects of CPF, singly or in mixtures, on the inland "Pejerrey" (Odontesthes bonariensis) under laboratory conditions...
May 9, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29744212/cleaning-effect-of-osteoconductive-powder-abrasive-treatment-on-explanted-human-implants-and-biofilm-coated-titanium-discs
#14
Ceylin S Tastepe, Xingnan Lin, Arie Werner, Marcel Donnet, Daniel Wismeijer, Yuelian Liu
The aim of this study is to test the cleaning effect and surface modification of a new implant surface treatment on explanted dental implants and titanium discs. It is a modified air powder abrasive (APA) treatment applied using osteoconductive powders. Twenty-eight in vitro Ca-precipitated organic film-coated titanium discs and 13 explanted dental implants were treated. In a 2-step approach, 3 powders were used: hydroxylapatite (HA) and biomimetic calcium phosphate (BioCaP), which are osteoconductive, and erythritol, which is not...
February 2018: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29740190/does-duration-of-caffeine-therapy-in-preterm-infants-born-%C3%A2-1250-g-at-birth-influence-neurodevelopmental-nd-outcomes-at-3-years-of-age
#15
A Lodha, Y Rabi, A Soraisham, J Dobry, Arijit Lodha, H Amin, E Al Awad, S Tang, A Sahai, V Bhandari
OBJECTIVE: To evaluate the effect of duration of caffeine use on long-term neurodevelopmental (ND) outcomes at 3 years corrected age (CA) in preterm infants with birthweights (BW) ≤ 1250 g. DESIGN/METHODS: All surviving infants with BW ≤ 1250 g admitted to the Foothills Medical Center neonatal intensive care unit (NICU) from January 2002 to December 2009 who received the first dose of caffeine in the first week of life and were followed up at three years CA were included in the study...
May 8, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29728867/check-point-inhibitors-a-new-era-in-renal-cell-carcinoma-treatment
#16
REVIEW
Mohamed Alsharedi, Heather Katz
In the United States, the estimated number of new cases of renal cell carcinoma (RCC) is approximately 65,000 case with about 15,000 deaths in the year of 2018 (Siegel et al. in CA Cancer J Clin 68(1):7, 2018). RCC as an immunogenic malignancy is supported by many theories and facts which include tumor richness of lymphocytes infiltrate, the occurrence of spontaneous tumor regression, and the proved effect of traditional immunotherapy (Finke et al. in J Immunother 11(1):1-11, 1992), all these factors support the potential therapeutic effect of the novel immunotherapeutic agents in RCC...
May 4, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29720987/surface-properties-and-permeability-to-calcium-chloride-of-fagus-sylvatica-and-quercus-petraea-leaves-of-different-canopy-heights
#17
Héctor A Bahamonde, Luis Gil, Victoria Fernández
Plant surfaces have a considerable degree of chemical and physical variability also in relation to different environmental conditions, organs and state of development. The potential changes on plant surface properties in association with environmental variations have been little explored so far. Using two model tree species (i.e., Quercus petraea , sessile oak and Fagus sylvatica , beech) growing in 'Montejo de la Sierra Forest,' we examined various traits of the abaxial and adaxial surface of leaves of both species collected at a height of approximately 15 m (top canopy), versus 3...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29720881/a-novel-nomogram-for-the-prediction-of-intrahepatic-cholangiocarcinoma-in-patients-with-intrahepatic-lithiasis-complicated-by-imagiologically-diagnosed-mass
#18
Gang Chen, Huajun Yu, Yi Wang, Chenhao Li, Mengtao Zhou, Zhengping Yu, Xiangwu Zheng, Xiuling Wu, Yunfeng Shan, Qiyu Zhang, Qiqiang Zeng
Background: Accurate preoperative diagnosis of intrahepatic cholangiocarcinoma (ICC) among patients with imagiologically intrahepatic lithiasis (IHL) complicated by mass is crucial for timely and effective surgical intervention. The aim of the present study was to develop a nomogram to identify ICC associated with IHL (IHL-ICC). Patients and methods: Data were obtained from a total of 252 consecutive patients with IHL complicated by mass. Multivariate logistic regression analysis was conducted to identify the clinicopathologic and imagiological characteristics that were potentially associated with ICC...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29719756/magnetic-characterization-of-cobalt-nanowires-and-square-nanorings-fabricated-by-focused-electron-beam-induced-deposition
#19
Federico Venturi, Gian Carlo Gazzadi, Amir H Tavabi, Alberto Rota, Rafal E Dunin-Borkowski, Stefano Frabboni
The magnetic properties of nanowires (NWs) and square nanorings, which were deposited by focused electron beam induced deposition (FEBID) of a Co carbonyl precursor, are studied using off-axis electron holography (EH), Lorentz transmission electron microscopy (L-TEM) and magnetic force microscopy (MFM). EH shows that NWs deposited using beam energies of 5 and 15 keV have the characteristics of magnetic dipoles, with larger magnetic moments observed for NWs deposited at lower energy. L-TEM is used to image magnetic domain walls in NWs and nanorings and their motion as a function of applied magnetic field...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29719194/mineral-constituents-in-leccinum-scabrum-from-lowland-locations-in-the-central-europe-and-their-relation-to-concentration-in-forest-topsoil
#20
Jerzy Falandysz
Leccinum scabrum is an edible mushroom common in European regions in the northern hemisphere. Macro and trace mineral constituents such as Ag, Al, Ba, Ca, Cd, Co, Cu, Fe, K, Mg, Mn, Na, Ni, Pb, P, Rb, Sr and Zn were studied in L. scabrum and in the top soil collected from the same location underneath soil substratum. The "pseudo-total" and labile (extractable fraction of minerals) were measured to get insight into the levels, distribution between the morphological parts of fruiting bodies, potential for their bioconcentration by mushroom and evaluated for human exposure via consumption of the mushroom...
May 2, 2018: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
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