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Informant discrepancies

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https://www.readbyqxmd.com/read/29332038/sex-influences-the-accuracy-of-subjective-memory-complaint-reporting-in-older-adults
#1
Erin E Sundermann, Emily C Edmonds, Lisa Delano-Wood, Douglas R Galasko, David P Salmon, Leah H Rubin, Mark W Bondi
Subjective memory complaints (SMC) are required when diagnosing amnestic mild cognitive impairment (aMCI), although their relationship with objective memory performance and Alzheimer's disease (AD) pathology remains unclear. We investigated whether the sex of the patient/participant moderates these associations. Participants were 940 normal control (NC) and aMCI participants from the Alzheimer's Disease Neuroimaging Initiative. SMC were assessed via the memory scale of the Everyday Cognition questionnaire. Discrepancy scores were calculated between self- and informant-reports and categorized into "overestimates," "comparable estimates", and "underestimates" of SMC...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29331134/coarse-grained-model-of-nanoscale-segregation-water-diffusion-and-proton-transport-in-nafion-membranes
#2
Aleksey Vishnyakov, Runfang Mao, Ming-Tsung Lee, Alexander V Neimark
We present a coarse-grained model of the acid form of Nafion membrane that explicitly includes proton transport. This model is based on a soft-core bead representation of the polymer implemented into the dissipative particle dynamics (DPD) simulation framework. The proton is introduced as a separate charged bead that forms dissociable Morse bonds with water beads. Morse bond formation and breakup artificially mimics the Grotthuss hopping mechanism of proton transport. The proposed DPD model is parameterized to account for the specifics of the conformations and flexibility of the Nafion backbone and sidechains; it treats electrostatic interactions in the smeared charge approximation...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29326188/managing-cognitive-impairment-following-stroke-protocol-for-a-systematic-review-of-non-randomised-controlled-studies-of-psychological-interventions
#3
Niamh A Merriman, Eithne Sexton, Nora-Ann Donnelly, Grainne McCabe, Mary E Walsh, Daniela Rohde, Ashleigh Gorman, Isabelle Jeffares, Niall Pender, David Williams, Frances Horgan, Frank Doyle, Maev-Ann Wren, Kathleen E Bennett, Anne Hickey
INTRODUCTION: Stroke is one of the primary causes of death and disability worldwide, leaving a considerable proportion of survivors with persistent cognitive and functional deficits. Despite the prevalence of poststroke cognitive impairment, there is no established treatment aimed at improving cognitive function following a stroke. Therefore, the aims of this systematic review are to identify psychological interventions intended to improve poststroke cognitive function and establish their efficacy...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29322475/the-scope-of-drug-related-problems-in-the-home-care-setting
#4
REVIEW
Carla Meyer-Massetti, Christoph R Meier, B Joseph Guglielmo
Introduction While drug-related problems (DRPs) in the inpatient setting are well known, the scope of these problems in home care has not been critically evaluated. Aim of the Review Our primary objective was to evaluate the incidence and demographics of DRPs in home care. Our specific aims were to characterize the rate of potentially inappropriate medications (PIMs), medication errors (MEs) and adverse drug events (ADEs) and to identify risk factors which contribute to DRPs in the home care setting. Methods Pubmed, Embase and CiNAHL databases were systematically searched from January 2000 to December 2016 for all publications which quantitatively characterized DRPs in the home care setting...
January 11, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29319797/an-in-silico-comparison-of-protocols-for-dated-phylogenomics
#5
Rupert A Collins, Tomas Hrbek
In the age of genome-scale DNA sequencing, choice of molecular marker arguably remains an important decision in planning a phylogenetic study. Using published genomes from 23 primate species, we make a standardized comparison of four of the most frequently used protocols in phylogenomics, viz., targeted sequence-enrichment using ultraconserved element and exon-capture probes, and restriction-site-associated DNA sequencing (RADseq and ddRADseq). Here, we present a procedure to perform in silico extractions from genomes and create directly comparable data sets for each class of marker...
January 8, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29319155/economic-evaluation-and-cost-of-interventions-for-cerebral-palsy-a-systematic-review
#6
REVIEW
Sophy T F Shih, Utsana Tonmukayakul, Christine Imms, Dinah Reddihough, H Kerr Graham, Liz Cox, Rob Carter
AIM: Economic appraisal can help guide policy-making for purchasing decisions, and treatment and management algorithms for health interventions. We conducted a systematic review of economic studies in cerebral palsy (CP) to inform future research. METHOD: Economic studies published since 1970 were identified from seven databases. Two reviewers independently screened abstracts and extracted data following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
January 10, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29318615/playing-off-the-beat-applying-the-jazz-paradigm-to-psychotherapy
#7
David Read Johnson
A jazz paradigm is applied to traditional psychotherapy practice, illuminating the links between psychotherapy and the Romantic aesthetic tradition, primarily in the centrality of concepts such as attunement. Modernist disruptions of realism during the early 20th century, such as jazz, elaborated dissonant and improvisational artistic impulses that brought new vitality to their art forms. The psychotherapeutic relationship also has potential avenues for multilevel and discrepant communication that open possibilities of freedom...
January 10, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29316282/are-multiple-sinus-cultures-necessary-during-sinus-surgery-for-chronic-rhinosinusitis
#8
Craig Miller, Greg E Davis
BACKGROUND: Multiple cultures are commonly obtained from different sinuses where purulence is encountered during endoscopic sinus surgery (ESS). This brings into question the utility and necessity of obtaining multiple cultures. The purpose of this study was to evaluate if multiple cultures obtained during a single case is informative in finding additional pathogens or if it is a redundant, cost-increasing practice. We hypothesized that multiple sinus cultures are necessary to identify the pathogens responsible for an individual's sinus disease...
January 5, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29311587/phenology-information-contributes-to-reduce-temporal-basis-risk-in-agricultural-weather-index-insurance
#9
Tobias Dalhaus, Oliver Musshoff, Robert Finger
Weather risks are an essential and increasingly important driver of agricultural income volatility. Agricultural insurances contribute to support farmers to cope with these risks. Among these insurances, weather index insurances (WII) are an innovative tool to cope with climatic risks in agriculture. Using WII, farmers receive an indemnification not based on actual yield reductions but are compensated based on a measured weather index, such as rainfall at a nearby weather station. The discrepancy between experienced losses and actual indemnification, basis risk, is a key challenge...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29309534/skeletal-muscle-power-measurement-in-older-people-a-systematic-review-of-testing-protocols-and-adverse-events
#10
Julian Alcazar, Amelia Guadalupe-Grau, Francisco J García-García, Ignacio Ara, Luis M Alegre
Background: Muscle power has been proposed to be the primary therapeutic target for resistance training interventions aimed at enhancing physical function in older adults. However, no recommendations exist on ideal testing protocols to assess muscle power in older adults, and the safety of this procedure has not been adequately evaluated in the literature. Methods: A systematic review was conducted to identify studies evaluating muscle power exerted by older people in resistance exercises through May 2017...
November 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29306929/comparison-between-two-inhibin-b-elisa-assays-in-46-xy-testicular-disorders-of-sex-development-dsd-with-normal-testosterone-secretion
#11
Guilherme Guaragna-Filho, Antônio Ramos Calixto, Georgette Beatriz De Paula, Laurione Cândido De Oliveira, André Moreno Morcillo, Maricilda Palandi De Mello, Andrea Trevas Maciel-Guerra, Gil Guerra-Junior
BACKGROUND: Inhibin B is a hormone produced by the Sertoli cells that can provide important information for the investigation of disorders of sex development (DSD) with 46,XY karyotype. The aim of this study is to compare two enzyme-linked immunosorbent assay (ELISA) assays for dosage of serum inhibin B in patients with 46,XY DSD with normal testosterone secretion. METHODS: Twenty-nine patients with 46,XY DSD and normal testosterone secretion (partial androgen insensitivity syndrome [PAIS] [n=8]; 5α-reductase deficiency [n=7] and idiopathic 46,XY DSD [n=14]) were included...
January 8, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29306048/comparison-of-cumulant-expansion-and-q-space-imaging-estimates-for-diffusional-kurtosis-in-brain
#12
Vaibhav Mohanty, Emilie T McKinnon, Joseph A Helpern, Jens H Jensen
PURPOSE: To compare estimates for the diffusional kurtosis in brain as obtained from a cumulant expansion (CE) of the diffusion MRI (dMRI) signal and from q-space (QS) imaging. THEORY AND METHODS: For the CE estimates of the kurtosis, the CE was truncated to quadratic order in the b-value and fit to the dMRI signal for b-values from 0 up to 2000s/mm2. For the QS estimates, b-values ranging from 0 up to 10,000s/mm2 were used to determine the diffusion displacement probability density function (dPDF) via Stejskal's formula...
January 3, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29300889/evaluating-quality-standards-adherence-in-surgical-care-a-case-study-from-pakistan
#13
Iram Fatima, Ayesha Humayun, Muhammad Imran Anwar, Muhammad Shafiq
Objective: To explore the extent of adherence to surgical quality standards and areas of improvement. Design: Multi-method case study was done. Assessment of observed/actual and self-reported adherence to quality standards in surgical care was done on WHO's safe-surgery checklist. Client satisfaction through exit interviews assessed of all operated during 1 month. Semi-structured interviews of key informants were conducted to identify areas of improvements in surgical care in this hospital...
December 27, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29300387/patient-understanding-of-satisfaction-with-and-perceived-utility-of-whole-genome-sequencing-findings-from-the-medseq-project
#14
J Scott Roberts, Jill O Robinson, Pamela M Diamond, Archana Bharadwaj, Kurt D Christensen, Kaitlyn B Lee, Robert C Green, Amy L McGuire
PurposeTo examine patients' experiences with clinical use of whole-genome sequencing (WGS).MethodsA randomized trial compared primary care and cardiology patients receiving WGS and family health history (FH) information or FH information alone. 202 patients were surveyed before (BL) and up to 6 months after disclosure of results (6M).ResultsPatients (mean age = 55 years; 50% female; 81% college graduates) reported low levels of decisional regret (mean: 7.1/100) and high satisfaction with physicians' disclosure of results (median: 29/30)...
January 4, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29298341/3d-reconstruction-of-coronary-arteries-from-2d-angiographic-projections-using-non-uniform-rational-basis-splines-nurbs-for-accurate-modelling-of-coronary-stenoses
#15
Francesca Galassi, Mohammad Alkhalil, Regent Lee, Philip Martindale, Rajesh K Kharbanda, Keith M Channon, Vicente Grau, Robin P Choudhury
OBJECTIVE: Assessment of coronary stenosis severity is crucial in clinical practice. This study proposes a novel method to generate 3D models of stenotic coronary arteries, directly from 2D coronary images, and suitable for immediate assessment of the stenosis severity. METHODS: From multiple 2D X-ray coronary arteriogram projections, 2D vessels were extracted. A 3D centreline was reconstructed as intersection of surfaces from corresponding branches. Next, 3D luminal contours were generated in a two-step process: first, a Non-Uniform Rational B-Spline (NURBS) circular contour was designed and, second, its control points were adjusted to interpolate computed 3D boundary points...
2018: PloS One
https://www.readbyqxmd.com/read/29290297/evaluation-of-three-serological-tests-for-diagnosis-of-bovine-brucellosis-in-smallholder-farms-in-pakistan-by-estimating-sensitivity-and-specificity-using-bayesian-latent-class-analysis
#16
Shumaila Arif, Jane Heller, Marta Hernandez-Jover, David M McGill, Peter C Thomson
The present study aimed to estimate the herd-level sensitivity (Se) and specificity (Sp) of three commonly used serological tests in naturally-infected cattle and buffalo in smallholder farms in Pakistan. Between February and June 2015, a cross-sectional study was carried out in five districts of Punjab (Kasur, Okara, Pakpattan, Jhelum, and Bhakkar) and two districts of Sindh (Badin and Thatta). Serum samples from mixed farms of cattle (n=441) and buffalo (n=621) were collected and tested using the Rose Bengal test (RBT), indirect ELISA (I-ELISA) and competitive ELISA (C-ELISA)...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29289974/perception-of-lower-urinary-tract-symptoms-by-psychiatrists-in-mentally-affected-patients
#17
Mikolaj Przydacz, Tomasz Golabek, Jerzy A Sobański, Karolina Jaworska, Michal Skalski, Agata Świerkosz, Przemyslaw Dudek, Dariusz Sobieraj, Dominika Dudek, Piotr Chłosta
OBJECTIVES: Lower urinary tract symptoms (LUTS) are highly prevalent and costly condition worldwide. Numerous studies have demonstrated their negative impact on health-related quality of life (HRQL), as well as on physical and mental health. The co-existence of LUTS and psychiatric symptoms is common and has been described by psychiatrists, urologists and gynecologists. However, data are lacking regarding the perception of urological symptoms by psychiatrists in their day-to-day clinical practice...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29289147/brownian-motion-probe-for-water-ethanol-inhomogeneous-mixtures
#18
Kazuki Furukawa, Ken Judai
Brownian motion provides information regarding the microscopic geometry and motion of molecules, insofar as it occurs as a result of molecular collisions with a colloid particle. We found that the mobility of polystyrene beads from the Brownian motion in a water-ethanol mixture is larger than that predicted from the liquid shear viscosity. This indicates that mixing water and ethanol is inhomogeneous in micron-sized probe beads. The discrepancy between the mobility of Brownian motion and liquid mobility can be explained by the way the rotation of the beads in an inhomogeneous viscous solvent converts the translational movement...
December 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29288559/omitting-cytogenetic-assessment-from-routine-treatment-response-monitoring-in-cml-is-safe
#19
Inge G P Geelen, Noortje Thielen, Jeroen J W M Janssen, Mels Hoogendoorn, Tanja J A Roosma, Peter J M Valk, Otto Visser, Jan J Cornelissen, Peter E Westerweel
OBJECTIVES: The monitoring of response in chronic myeloid leukemia (CML) is of great importance to identify patients failing their treatment in order to adjust TKI choice and thereby prevent progression to advanced stage disease. Cytogenetic monitoring has a lower sensitivity, is expensive, and requires invasive bone marrow sampling. Nevertheless, chronic myeloid leukemia guidelines continue to recommend performing routine cytogenetic response assessments, even when adequate molecular diagnostics are available...
December 29, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29287948/readability-of-the-most-commonly-accessed-arthroscopy-related-online-patient-education-materials
#20
Sheriff D Akinleye, Ryan Krochak, Nicholas Richardson, Garret Garofolo, Maya Deza Culbertson, Orry Erez
PURPOSE: To assess the readability and comprehension of written text by the most commonly visited websites containing patient education materials on common conditions that can be treated arthroscopically. METHODS: We examined 50 websites, assessed independently by 2 orthopaedic surgery residents (S.A. and G.G.), with educational materials on 5 common conditions treated by arthroscopic surgeons: anterior cruciate ligament (ACL) tear, meniscus tear, hip labral tear, shoulder labral tear, and rotator cuff tear...
December 26, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
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