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Informant discrepancies

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https://www.readbyqxmd.com/read/27914898/conflict-of-evidence-resolving-discrepancies-when-findings-from-randomized-controlled-trials-and-meta-analyses-disagree
#1
REVIEW
Richard J Sylvester, Steven E Canfield, Thomas B L Lam, Lorenzo Marconi, Steven MacLennan, Yuhong Yuan, Graeme MacLennan, John Norrie, Muhammad Imran Omar, Harman M Bruins, Virginia Hernández, Karin Plass, Hendrik Van Poppel, James N'Dow
CONTEXT: Clinicians and treatment guideline developers are faced with a dilemma when the results of a new, large, well-conducted randomized controlled trial (RCT) are in direct conflict with the results of a previous systematic review (SR) and meta-analysis (MA). OBJECTIVE: To explore and discuss possible reasons for disagreement in results from SRs/MAs and RCTs and to provide guidance to clinicians and guideline developers for making well-informed treatment decisions and recommendations in the face of conflicting data...
November 30, 2016: European Urology
https://www.readbyqxmd.com/read/27914225/cortical-stimulation-parameters-for-functional-mapping
#2
Jacquelyn A Corley, Pouya Nazari, Vincent J Rossi, Nora C Kim, Louis F Fogg, Thomas J Hoeppner, Travis R Stoub, Richard W Byrne
PURPOSE: There is significant variation in how patients respond to cortical electrical stimulation. It has been hypothesized that individual demographic and pathologic factors, such as age, sex, disease duration, and MRI findings, may explain this discrepancy. The purpose of our study is to identify specific patient characteristics and their effect on cortical stimulation, and discover the extent of variation in behavioral responses that exists among patients with epilepsy. METHOD: We retrospectively analyzed data from 92 patients with medically intractable epilepsy who had extra-operative cortical electrical stimulation...
November 23, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27913314/audiologic-characteristics-in-a-sample-of-recently-separated-military-veterans-the-noise-outcomes-in-servicemembers-epidemiology-study-noise-study
#3
J S Gordon, S E Griest, E J Thielman, K C Carlson, W J Helt, M S Lewis, C Blankenship, D Austin, S M Theodoroff, J A Henry
Military Service Members are often exposed to high levels of occupational noise, solvents, and other exposures that can be damaging to the auditory system. Little is known about hearing loss and how it progresses in Veterans following military service. This epidemiology study is designed to evaluate and monitor a cohort of Veterans for 20 years or more to determine how hearing loss changes over time and how those changes are related to noise exposure and other ototoxic exposures encountered during military service...
November 29, 2016: Hearing Research
https://www.readbyqxmd.com/read/27912920/the-relationship-between-therapist-rated-function-and-patient-reported-outcome-measures
#4
Yvonne Braun, Jos J Mellema, Rinne M Peters, Suzanne Curley, Gae Burchill, David Ring
STUDY DESIGN: Prospective cohort study. INTRODUCTION: Some third-party payers require hand therapists to rate patient's functional disability based on patient self-rating using patient-reported outcome measures (PROMs), objective measurements of impairment, and observation of functional tasks-hand therapist-rated function (HTRF). PURPOSE OF THE STUDY: To test the correlation between HTRF and PROMs (upper limb functional index [ULFI] and Patient-Reported Outcomes Measurement Information System upper extremity [PROMIS UE]) and its association with psychological factors...
November 29, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27908833/pilot-evaluation-of-a-method-to-assess-prescribers-information-processing-of-medication-alerts
#5
Alissa L Russ, Brittany L Melton, Joanne K Daggy, Jason J Saleem
BACKGROUND: Prescribers commonly receive alerts during medication ordering. Prescribers work in a complex, time-pressured environment; to enhance the effectiveness of safety alerts, the effort needed to cognitively process these alerts should be minimized. Methods to evaluate the extent to which computerized alerts support prescribers' information processing are lacking. OBJECTIVE: To develop a methodological protocol to assess the extent to which alerts support prescribers' information processing at-a-glance; specifically, the incorporation of information into working memory...
November 28, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27908187/dosimetric-characterization-of-mri-only-treatment-planning-for-brain-tumors-in-atlas-based-pseudo-ct-images-generated-from-standard-t1-weighted-mr-images
#6
Benjamin Demol, Christine Boydev, Juha Korhonen, Nick Reynaert
PURPOSE: Magnetic resonance imaging (MRI)-only radiotherapy treatment planning requires accurate pseudo-CT (pCT) images for precise dose calculation. The current work introduced an atlas-based method combined with MR intensity information. pCT analyses and Monte Carlo dose calculations for intracranial stereotactic treatments were performed. METHODS: Twenty-two patients, representing 35 tumor targets, were scanned using a 3D T1-weighted MRI sequence according to the clinical protocol...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27907836/implications-of-adopting-a-biodiversity-based-vulnerability-index-versus-a-shoreline-environmental-sensitivity-index-on-management-and-policy-planning-along-coastal-areas
#7
G Harik, I Alameddine, R Maroun, G Rachid, D Bruschi, D Astiaso Garcia, M El-Fadel
In this study, a multi-criteria index was developed to assess anthropogenic stressors along the Mediterranean coastline. The index aimed at geo-locating pollution hotspots for informed decision making related to coastal zone management. The index was integrated in a Geographical Information System based geodatabase implemented at several pilot areas along the Northern (Italy and France), Eastern (Lebanon), and Southern (Tunisia) Mediterranean coastlines. The generated stressor maps were coupled with a biodiversity richness index and an environmental sensitivity index to produce vulnerability maps that can form the basis for prioritizing management and mitigation interventions towards the identification of pollution hotspots and the promotion of sustainable coastal zone management...
November 28, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27905962/identifying-potential-differences-in-cause-of-death-coding-practices-across-russian-regions
#8
Inna Danilova, Vladimir M Shkolnikov, Dmitri A Jdanov, France Meslé, Jacques Vallin
BACKGROUND: Reliable and comparable data on causes of death are crucial for public health analysis, but the usefulness of these data can be markedly diminished when the approach to coding is not standardized across territories and/or over time. Because the Russian system of producing information on causes of death is highly decentralized, there may be discrepancies in the coding practices employed across the country. In this study, we evaluate the uniformity of cause-of-death coding practices across Russian regions using an indirect method...
March 22, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27902745/utility-of-the-health-of-the-nation-outcome-scales-honos-in-predicting-mental-health-service-costs-for-patients-with-common-mental-health-problems-historical-cohort-study
#9
Conal Twomey, A Matthew Prina, David S Baldwin, Jayati Das-Munshi, David Kingdon, Leonardo Koeser, Martin J Prince, Robert Stewart, Alex D Tulloch, Alarcos Cieza
BACKGROUND: Few countries have made much progress in implementing transparent and efficient systems for the allocation of mental health care resources. In England there are ongoing efforts by the National Health Service (NHS) to develop mental health 'payment by results' (PbR). The system depends on the ability of patient 'clusters' derived from the Health of the Nation Outcome Scales (HoNOS) to predict costs. We therefore investigated the associations of individual HoNOS items and the Total HoNOS score at baseline with mental health service costs at one year follow-up...
2016: PloS One
https://www.readbyqxmd.com/read/27900953/feedback-control-policies-employed-by-people-using-intracortical-brain-computer-interfaces
#10
Francis R Willett, Chethan Pandarinath, Beata Jarosiewicz, Brian A Murphy, William D Memberg, Christine H Blabe, Jad Saab, Benjamin L Walter, Jennifer A Sweet, Jonathan P Miller, Jaimie M Henderson, Krishna V Shenoy, John D Simeral, Leigh R Hochberg, Robert F Kirsch, A Bolu Ajiboye
OBJECTIVE: When using an intracortical BCI (iBCI), users modulate their neural population activity to move an effector towards a target, stop accurately, and correct for movement errors. We call the rules that govern this modulation a 'feedback control policy'. A better understanding of these policies may inform the design of higher-performing neural decoders. APPROACH: We studied how three participants in the BrainGate2 pilot clinical trial used an iBCI to control a cursor in a 2D target acquisition task...
November 30, 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27894349/-when-i-saw-walking-i-just-kind-of-took-it-as-wheeling-interpretations-of-mobility-related-items-in-generic-preference-based-health-state-instruments-in-the-context-of-spinal-cord-injury
#11
Yvonne Anne Michel, Lidia Engel, Kim Rand-Hendriksen, Liv Ariane Augestad, David Gt Whitehurst
BACKGROUND: In health economic analyses, health states are typically valued using instruments with few items per dimension. Due to the generic (and often reductionist) nature of such instruments, certain groups of respondents may experience challenges in describing their health state. This study is concerned with generic, preference-based health state instruments that provide information for decisions about the allocation of resources in health care. Unlike physical measurement instruments, preference-based health state instruments provide health state values that are dependent on how respondents interpret the items...
November 28, 2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27894331/a-systematic-review-of-patient-safety-in-mental-health-a-protocol-based-on-the-inpatient-setting
#12
Danielle D'Lima, Stephanie Archer, Bethan Ines Thibaut, Sonny Christian Ramtale, Lindsay H Dewa, Ara Darzi
BACKGROUND: Despite the growing international interest in patient safety as a discipline, there has been a lack of exploration of its application to mental health. It cannot be assumed that findings based upon physical health in acute care hospitals can be applied to mental health patients, disorders and settings. To the authors' knowledge, there has only been one review of the literature that focuses on patient safety research in mental health settings, conducted in Canada in 2008. We have identified a need to update this review and develop the methodology in order to strengthen the findings and disseminate internationally for advancement in the field...
November 29, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27890805/predicting-brain-age-from-multimodal-imaging-data-captures-cognitive-impairment
#13
Franziskus Liem, Gaël Varoquaux, Jana Kynast, Frauke Beyer, Shahrzad Kharabian Masouleh, Julia M Huntenburg, Leonie Lampe, Mehdi Rahim, Alexandre Abraham, R Cameron Craddock, Steffi Riedel-Heller, Tobias Luck, Markus Loeffler, Matthias L Schroeter, Anja Veronica Witte, Daniel S Margulies
The disparity between the chronological age of an individual and their brain-age measured based on biological information has the potential to offer clinically-relevant biomarkers of neurological syndromes that emerge late in the lifespan. While prior brain-age prediction studies have relied exclusively on either structural or functional brain data, here we investigate how multimodal brain-imaging data improves age prediction. Using cortical anatomy and whole-brain functional connectivity on a large adult lifespan sample (N=2354, age 19-82), we found that multimodal data improves brain-based age prediction, resulting in a mean absolute prediction error of 4...
November 23, 2016: NeuroImage
https://www.readbyqxmd.com/read/27889153/metagenomics-reveals-flavour-metabolic-network-of-cereal-vinegar-microbiota
#14
Lin-Huan Wu, Zhen-Ming Lu, Xiao-Juan Zhang, Zong-Min Wang, Yong-Jian Yu, Jin-Song Shi, Zheng-Hong Xu
Multispecies microbial community formed through centuries of repeated batch acetic acid fermentation (AAF) is crucial for the flavour quality of traditional vinegar produced from cereals. However, the metabolism to generate and/or formulate the essential flavours by the multispecies microbial community is hardly understood. Here we used metagenomic approach to clarify in situ metabolic network of key microbes responsible for flavour synthesis of a typical cereal vinegar, Zhenjiang aromatic vinegar, produced by solid-state fermentation...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27887666/contributions-of-national-and-global-health-estimates-to-monitoring-health-related-sustainable-development-goals
#15
Kanitta Bundhamcharoen, Supon Limwattananon, Khanitta Kusreesakul, Viroj Tangcharoensathien
The millennium development goals triggered an increased demand for data on child and maternal mortalities for monitoring progress. With the advent of the sustainable development goals and growing evidence of an epidemiological transition toward non-communicable diseases, policymakers need data on mortality and disease trends and distribution to inform effective policies and support monitoring progress. Where there are limited capacities to produce national health estimates (NHEs), global health estimates (GHEs) can fill gaps for global monitoring and comparisons...
2016: Global Health Action
https://www.readbyqxmd.com/read/27885641/apophyseal-ossification-of-the-iliac-crest-in-forensic-age-estimation-computed-tomography-standards-for-modern-australian-subadults
#16
Nicolene Lottering, Clair L Alston-Knox, Donna M MacGregor, Maree T Izatt, Caroline A Grant, Clayton J Adam, Laura S Gregory
This study contrasts the ontogeny of the iliac crest apophysis using conventional radiography and multislice computed tomography (MSCT), providing probabilistic information for age estimation of modern Australian subadults. Retrospective abdominopelvic MSCT data acquired from 524 Australian individuals aged 7-25 and surveillance radiographs of adolescent idiopathic scoliosis patients included in the Paediatric Spine Research Group Progression Study (n = 531) were assessed. Ossification scoring of pseudo-radiographs and three-dimensional (3D) volume-rendered reconstructions using Risser (1958) quantitative descriptors indicate discrepancies in age estimates, stage allocation, and conflicting morphological progression...
November 25, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27885553/biosimilars-for-the-treatment-of-chronic-inflammatory-diseases-a-systematic-review-of-published-evidence
#17
REVIEW
Ira Jacobs, Danielle Petersel, Leah Isakov, Sadiq Lula, K Lea Sewell
BACKGROUND: Clinicians are required to assimilate, critically evaluate, and extrapolate information to support appropriate use of biosimilars across indications. OBJECTIVES: The objective of this study was to systematically collate all published data in order to assess the weight (quantity and quality) of available evidence for each molecule and inform and support healthcare decision-making in chronic inflammatory diseases. METHODS: MEDLINE(®), EMBASE(®), and ISI Web of Science(®) were searched to September 2015...
December 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/27884180/the-impact-of-mhealth-interventions-on-health-systems-a-systematic-review-protocol
#18
Jill Fortuin, Faatiema Salie, Leila H Abdullahi, Tania S Douglas
BACKGROUND: Mobile health (mHealth) has been described as a health enabling tool that impacts positively on the health system in terms of improved access, quality and cost of health care. The proposed systematic review will examine the impact of mHealth on health systems by assessing access, quality and cost of health care as indicators. METHODS: The systematic review will include literature from various sources including published and unpublished/grey literature...
November 25, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27879541/ethical-barriers-in-adolescent-oncofertility-counseling
#19
Daniel V Runco, Julia F Taylor, Paul R Helft
Adult survivors of pediatric cancers are at substantial risk for infertility. Oncofertility is an emerging field in medicine that has focused on the fertility preservation of these patients. As the field continues to develop, there are several areas in which our practice has improved. However, several ethical concerns still exist involving beneficence, nonmaleficence, informed consent, adolescent assent, and posthumous use of reproductive tissues. Because the field is still developing, great disparities exist in available options depending on age, ability to pay, and geographic location...
November 22, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27875561/the-perception-of-physician-empathy-by-patients-with-inflammatory-bowel-disease
#20
Costanza Chiapponi, Maxie Witt, Gabriele E Dlugosch, Veit Gülberg, Matthias Siebeck
BACKGROUND AND AIMS: This study focused on the difference between perceived and desired physician empathy (pPE and dPE) in the eye of patients with inflammatory bowel disease (IBD). It was investigated if a discrepancy (ΔPE) correlates with trust and satisfaction of patients. At the same time the aim was to gain detailed information about the subjective burden of disease and the resources of IBD patients, in order to better understand them. METHODS: A modified version of the German Version of the Consultation and Relational Empathy (CARE) measure was completed as a paper-and-pencil questionnaire by IBD patients attending our facility (n = 32) and as an online survey by IBD patients at other locations throughout Germany (n = 89)...
2016: PloS One
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