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https://www.readbyqxmd.com/read/28535551/angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-modulate-the-function-of-myelinated-fibers-after-chemotherapy-a-quantitative-sensory-testing-study
#1
Carlos J Roldan, Juhee Song, Mitchell P Engle, Patrick M Dougherty
BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) have sufficient scientific support for their use as tissue protectors. Preliminary studies suggest that their angiotensin-II type 2 receptor (AT2R)-blocking properties have a beneficial profile in the treatment of neuropathic pain. OBJECTIVES: The purpose of the current study was to quantify the extent of the somatosensory effects of ACEI and ARB in cancer patients with chemotherapy-induced peripheral neuropathy...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535130/home-manufacture-of-drugs-an-online-investigation-and-a-toxicological-reality-check-of-online-discussions-on-drug-chemistry
#2
Evelyn Hearne, Emanuele Amorim Alves, Marie Claire Van Hout, Jean-Paul C Grund
Emerging trends in market dynamics and the use of new psychoactive substances are both a public health concern and a complex regulatory issue. One novel area of investigation is the availability of homemade opioids, amphetamines and dissociatives, and the potential fueling of interest in clandestine home manufacture of drugs via the Internet. We illustrate here how online communal folk pharmacology of homemade drugs on drug website forums may actually inform home manufacture practices or contribute to the reduction of harms associated with this practice...
May 23, 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/28532308/contributions-of-national-and-global-health-estimates-to-monitoring-health-related-sustainable-development-goals-in-thailand
#3
Kanitta Bundhamcharoen, Supon Limwattananon, Khanitta Kusreesakul, Viroj Tangcharoensathien
The Millennium Development Goals (MDGs) triggered increased demand for data on child and maternal mortality for monitoring progress. With the advent of the Sustainable Development Goals (SDGs) and growing evidence of an epidemiological transition towards non-communicable diseases, policy makers need data on mortality and disease trends and distribution to inform effective policies and support monitoring progress. Where there are limited capacities to produce national health estimates (NHEs), global health estimates (GHEs) can fill gaps for global monitoring and comparisons...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28532305/production-and-use-of-estimates-for-monitoring-progress-in-the-health-sector-the-case-of-bangladesh
#4
Karar Zunaid Ahsan, Tazeen Tahsina, Afrin Iqbal, Nazia Binte Ali, Suman Kanti Chowdhury, Tanvir M Huda, Shams El Arifeen
BACKGROUND:  In order to support the progress towards the post-2015 development agenda for the health sector, the importance of high-quality and timely estimates has become evident both globally and at the country level. OBJECTIVE AND METHODS: Based on desk review, key informant interviews and expert panel discussions, the paper critically reviews health estimates from both the local (i.e. nationally generated information by the government and other agencies) and the global sources (which are mostly modeled or interpolated estimates developed by international organizations based on different sources of information), and assesses the country capacity and monitoring strategies to meet the increasing data demand in the coming years...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28531659/risk-assessment-of-the-endocrine-disrupting-effects-of-nine-chiral-pesticides
#5
Qin Song, Yi Zhang, Lu Yan, Jinghua Wang, Chensheng Lu, Quan Zhang, Meirong Zhao
The increased release of chiral pesticides into the environment has generated interest in the role of enantioselectivity in the environmental fate and ecotoxicological effects of these compounds. However, the information on the endocrine disrupting effects (EDEs) of chiral pesticides is still limited and discrepancies are also usually observed among different assays. In this study, we investigated the enantioselectivity of EDEs via estrogen and thyroid hormone receptors for nine chiral pesticides using in vitro and in silico approaches...
May 11, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28528268/optimistic-honesty-understanding-surgeon-and-patient-perspectives-on-hopeful-communication-in-pancreatic-cancer-care
#6
Kim Blakely, Paul J Karanicolas, Frances C Wright, Lesley Gotlib Conn
BACKGROUND: Prognosis conversations between surgical oncologists and patients with pancreatic cancer are critically important and challenging. Surgeons and their patients often have discrepant understandings of prognosis despite extensive conversations. Little is known about how surgeons approach prognosis conversations with these patients; patients' experiences with these conversations are also not well understood. This qualitative study sought to better understand surgeon and patient perspectives on communication in pancreatic cancer care with a view toward improvement...
May 17, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28526068/heat-pretreatment-of-canine-samples-to-evaluate-efficacy-of-imidacloprid%C3%A2-%C3%A2-moxidectin-and-doxycycline-in-heartworm-treatment
#7
Alexandre José Rodrigues Bendas, Flavya Mendes-de-Almeida, Cristiano Von Simson, Norma Labarthe
BACKGROUND: Considering the recent information on the increase of Dirofilaria immitis antigen detection by rapid assays in canine blood samples after heat treatment, the proposal that immune complexes block D. immitis antigen detection and that macrocyclic lactone + doxycycline (alternative protocol) might lead to increased production of those immune complexes, resulting in the erroneous diagnosis of adult worm elimination, and that there is no recommended adulticide marketed in Brazil, a study was performed to evaluate the interference of moxidectin + doxycycline (moxi-doxy) on diagnostic procedures when heartworm positive dogs are treated with this alternative protocol...
May 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28523218/valence-and-magnitude-ambiguity-in-feedback-processing
#8
Ruolei Gu, Xue Feng, Lucas S Broster, Lu Yuan, Pengfei Xu, Yue-Jia Luo
BACKGROUND: Outcome feedback which indicates behavioral consequences are crucial for reinforcement learning and environmental adaptation. Nevertheless, outcome information in daily life is often totally or partially ambiguous. Studying how people interpret this kind of information would provide important knowledge about the human evaluative system. METHODS: This study concentrates on the neural processing of partially ambiguous feedback, that is, either its valence or magnitude is unknown to participants...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28521155/is-laughter-a-better-vocal-change-detector-than-a-growl
#9
Ana P Pinheiro, Carla Barros, Margarida Vasconcelos, Christian Obermeier, Sonja A Kotz
The capacity to predict what should happen next and to minimize any discrepancy between an expected and an actual sensory input (prediction error) is a central aspect of perception. Particularly in vocal communication, the effective prediction of an auditory input that informs the listener about the emotionality of a speaker is critical. What is currently unknown is how the perceived valence of an emotional vocalization affects the capacity to predict and detect a change in the auditory input. This question was probed in a combined event-related potential (ERP) and time-frequency analysis approach...
April 11, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28521129/integrating-results-across-methodologies-is-essential-for-producing-robust-neuronal-taxonomies
#10
Mark S Cembrowski, Nelson Spruston
Elucidating the diversity and spatial organization of cell types in the brain is an essential goal of neuroscience, with many emerging technologies helping to advance this endeavor. Using a new in situ hybridization method that can measure the expression of hundreds of genes in a given mouse brain section (amplified seqFISH), Shah et al. (2016) describe a spatial organization of hippocampal cell types that differs from previous reports. In seeking to understand this discrepancy, we find that many of the barcoded genes used by seqFISH to characterize this spatial organization, when cross-validated by other sensitive methodologies, exhibit negligible expression in the hippocampus...
May 17, 2017: Neuron
https://www.readbyqxmd.com/read/28516854/mother-father-and-teacher-agreement-on-victimization-and-bullying-in-children-with-psychiatric-disorders
#11
Susan Dickerson Mayes, Susan L Calhoun, Farhat Siddiqui, Raman Baweja, Daniel A Waschbusch, Richard E Mattison, Dara E Babinski
Bullying is a significant international problem, and parent-teacher agreement on identifying perpetrators and victims is poor in general population studies. The goal of our study is to assess informant discrepancies in children with mental health disorders. Parents and teachers completed the Pediatric Behavior Scale as part of a diagnostic evaluation for 1,723 children (ages 2-16 years) referred to a psychiatry clinic over the past 10 years. Mother and father bullying and victimization ratings on the Pediatric Behavior Scale were similar, but parent-teacher agreement was poor...
May 17, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28515201/pre-versus-post-mass-extinction-divergence-of-mesozoic-marine-reptiles-dictated-by-time-scale-dependence-of-evolutionary-rates
#12
Ryosuke Motani, Da-Yong Jiang, Andrea Tintori, Cheng Ji, Jian-Dong Huang
The fossil record of a major clade often starts after a mass extinction even though evolutionary rates, molecular or morphological, suggest its pre-extinction emergence (e.g. squamates, placentals and teleosts). The discrepancy is larger for older clades, and the presence of a time-scale-dependent methodological bias has been suggested, yet it has been difficult to avoid the bias using Bayesian phylogenetic methods. This paradox raises the question of whether ecological vacancies, such as those after mass extinctions, prompt the radiations...
May 17, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28512308/quantum-key-distribution-with-hacking-countermeasures-and-long-term-field-trial
#13
A R Dixon, J F Dynes, M Lucamarini, B Fröhlich, A W Sharpe, A Plews, W Tam, Z L Yuan, Y Tanizawa, H Sato, S Kawamura, M Fujiwara, M Sasaki, A J Shields
Quantum key distribution's (QKD's) central and unique claim is information theoretic security. However there is an increasing understanding that the security of a QKD system relies not only on theoretical security proofs, but also on how closely the physical system matches the theoretical models and prevents attacks due to discrepancies. These side channel or hacking attacks exploit physical devices which do not necessarily behave precisely as the theory expects. As such there is a need for QKD systems to be demonstrated to provide security both in the theoretical and physical implementation...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28512128/refined-topology-model-of-the-stt3-sttp3-protein-subunit-of-the-oligosaccharyl-transferase-complex
#14
Patricia Lara, Karin Öjemalm, Johannes Reithinger, Aurora Holgado, You Maojun, Abdessalem Hammed, Daniel Mattle, Hyun Kim, IngMarie Nilsson
The oligosaccharyl transferase (OST) complex, localized in the endoplasmic reticulum (ER) of eukaryotic cells, is responsible for the N-linked glycosylation of numerous protein substrates. The membrane protein STT3 is a highly conserved part of the OST, and likely contains the active site of the complex. However, understanding the catalytic determinants of this system has been challenging, in part because of a discrepancy in the structural topology of the bacterial vs eukaryotic proteins and incomplete information about the mechanism of membrane integration...
May 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28511357/establishing-and-testing-a-catchment-water-footprint-framework-to-inform-sustainable-irrigation-water-use-for-an-aquifer-under-stress
#15
Betsie le Roux, Michael van der Laan, Teunis Vahrmeijer, Keith L Bristow, John G Annandale
Future water scarcities in the face of an increasing population, climate change and the unsustainable use of aquifers will present major challenges to global food production. The ability of water footprints (WFs) to inform water resource management at catchment-scale was investigated on the Steenkoppies Aquifer, South Africa. Yields based on cropping areas were multiplied with season-specific WFs for each crop to determine blue and green water consumption by agriculture. Precipitation and evapotranspiration of natural vegetation and other uses of blue water were included with the agricultural WFs to compare water availability and consumption in a catchment sustainability assessment...
May 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28508614/methods-for-rating-sexual-development-in-girls
#16
Vincenzo De Sanctis, Ihab Zaki Elhakim, Ashraf T Soliman, Heba Elsedfy, Rania Elalaily, Giuseppe Millimaggi
Sexual maturity rating (SMR) is important in population studies and in clinical care. Pubertal staging allows doctors to assess the maturation of adolescents to correlate several pubertal phenomena such as age at menarche, growth spurt and final height, to advise and manage patients appropriately and to have sensitive "sensors" of the effects of environmental exposure on human populations. The commonly used markers of the timing of female puberty are thelarche and menarche. Appearance of the breast bud is the first indicator of puberty onset in 90% of girls...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28506976/implementation-of-postdischarge-follow-up-telephone-calls-at-a-comprehensive-cancer-center
#17
Shrina D Patel, Phuoc Anh Anne Nguyen, Melissa Bachler, Bradley Atkinson
PURPOSE: The development and implementation of a pharmacy-driven, postdischarge follow-up telephone call program to assess medication adherence, provide education, and address medication-related concerns are discussed. SUMMARY: Many readmissions are avoidable through effective discharge planning and patient follow-up after hospitalization. However, there is limited information on how to effectuate this process. To address this barrier, a team consisting of a clinical pharmacy specialist, a clinical pharmacy manager, a postgraduate year 1 pharmacy resident, and an education specialist at The University of Texas MD Anderson Cancer Center collaborated to create a postdischarge telephone call program within a transitions-of-care (TOC) pilot program...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28506836/a-comprehensive-review-of-metal-induced-cellular-transformation-studies
#18
Qiao Yi Chen, Max Costa
In vitro transformation assays not only serve practical purposes in screening for potential carcinogenic substances in food, drug, and cosmetic industries, but more importantly, they provide a means of understanding the critical biological processes behind in vivo cancer development. In resemblance to cancer cells in vivo, successfully transformed cells display loss of contact inhibition, gain of anchorage independent growth, resistant to proper cell cycle regulation such as apoptosis, faster proliferation rate, potential for cellular invasion, and ability to form tumors in experimental animals...
May 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28505367/effect-of-health-information-exchange-on-recognition-of-medication-discrepancies-is-interrupted-when-data-charges-are-introduced-results-of-a-cluster-randomized-controlled-trial
#19
Kenneth S Boockvar, William Ho, Jennifer Pruskowski, Katherine E DiPalo, Jane J Wong, Jessica Patel, Jonathan R Nebeker, Rainu Kaushal, William Hung
Objectives: : To determine the effect of health information exchange (HIE) on medication prescribing for hospital inpatients in a cluster-randomized controlled trial, and to examine the prescribing effect of availability of information from a large pharmacy insurance plan in a natural experiment. Methods: : Patients admitted to an urban hospital received structured medication reconciliation by an intervention pharmacist with (intervention) or without (control) access to a regional HIE...
May 13, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28503140/gravity-as-a-strong-prior-implications-for-perception-and-action
#20
Björn Jörges, Joan López-Moliner
In the future, humans are likely to be exposed to environments with altered gravity conditions, be it only visually (Virtual and Augmented Reality), or visually and bodily (space travel). As visually and bodily perceived gravity as well as an interiorized representation of earth gravity are involved in a series of tasks, such as catching, grasping, body orientation estimation and spatial inferences, humans will need to adapt to these new gravity conditions. Performance under earth gravity discrepant conditions has been shown to be relatively poor, and few studies conducted in gravity adaptation are rather discouraging...
2017: Frontiers in Human Neuroscience
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