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Fibrocystic disease

Harald Rösner, Wolfgang Möller, Sabine Groebner, Pompilio Torremante
Clinical trials have revealed that molecular iodine (I2) has beneficial effects in fibrocystic breast disease and in cyclic mastalgia. Likewise, povidone-iodine (PVP-I), which is widely used in clinical practice as an antiseptic agent following tumour surgery, has been demonstrated to have cytotoxic effects on colon cancer and ascites tumour cells. Our previous study indicated that the growth of breast cancer and seven other human malignant cell lines was variably diminished by I2 and iodolactones. With the intention of developing an iodine-based anticancer therapy, the present investigations extended these studies by comparing the cytotoxic capacities of I2, potassium iodide (KJ), PVP-I and Lugol's solution on various human carcinoma cell lines...
September 2016: Oncology Letters
Qicai Chen, Juan Xiao, Pengpeng Zhang, Lili Chen, Xiaoxiao Chen, Shumei Wang
BACKGROUND: Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aimed to explore SUA among patients suffering from these diseases to enhance the hypothesis. METHODS: Overall, 1349 female participants were selected into three cases: Case I having uterine fibroids (n=568), Case II having fibrocycstic breast disease (n=608) and Case III having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls...
May 2016: Iranian Journal of Public Health
Anuradha Sehrawat, Claudette St Croix, Catherine J Baty, Simon Watkins, Dhanir Tailor, Rana P Singh, Shivendra V Singh
Benzyl isothiocyanate (BITC) is a highly promising phytochemical abundant in cruciferous vegetables with preclinical evidence of in vivo efficacy against breast cancer in xenograft and transgenic mouse models. Mammary cancer chemoprevention by BITC is associated with apoptotic cell death but the underlying mechanism is not fully understood. Herein, we demonstrate for the first time that altered mitochondrial dynamics is an early and critical event in BITC-induced apoptosis in breast cancer cells. Exposure of MCF-7 and MDA-MB-231 cells to plasma achievable doses of BITC resulted in rapid collapse of mitochondrial filamentous network...
September 2016: Mitochondrion
Mai Shibusawa, Ryohei Nakayama, Yuko Okanami, Yumi Kashikura, Nao Imai, Takashi Nakamura, Hiroko Kimura, Masako Yamashita, Noriko Hanamura, Tomoko Ogawa
PURPOSE: The purpose of this study was to evaluate the usefulness of a computer-aided diagnosis (CAD) scheme for improving the performance of clinicians to diagnose non-mass lesions appearing as hypoechoic areas on breast ultrasonographic images. METHODS: The database included 97 ultrasonographic images with hypoechoic areas: 48 benign cases [benign lesion with benign mammary tissue or fibrocystic disease (n = 20), fibroadenoma (n = 11), and intraductal papilloma (n = 17)] and 49 malignant cases [ductal carcinoma in situ (n = 17) and invasive ductal carcinoma (n = 32)]...
July 2016: Journal of Medical Ultrasonics
Anuradha Sehrawat, Su-Hyeong Kim, Eun-Ryeong Hahm, Julie A Arlotti, Julie Eiseman, Sruti S Shiva, Lora H Rigatti, Shivendra V Singh
The present study is the first to report inhibition of breast cancer cell growth in vitro and in vivo and suppression of self-renewal of breast cancer stem cells (bCSC) by a pine bark component (leelamine). Except for a few recent publications in melanoma, anticancer pharmacology of this interesting phytochemical is largely elusive. Leelamine (LLM) dose-dependently inhibited viability of MDA-MB-231 (triple-negative), MCF-7 (estrogen receptor-positive), and SUM159 (triple-negative) human breast cancer cells in association with apoptotic cell death induction...
May 5, 2016: Molecular Carcinogenesis
Fausto Famá, Marco Cicciú, Alessandro Sindoni, Paola Scarfó, Andrea Pollicino, Giuseppa Giacobbe, Giancarlo Buccheri, Filippo Taranto, Jessica Palella, Maria Gioffré-Florio
BACKGROUND: Ectopic breast tissue, which includes both supernumerary breast and aberrant breast tissue, is the most common congenital breast abnormality. Ectopic breast cancers are rare neoplasms that occur in 0.3% to 0.6% of all cases of breast cancer. PATIENTS AND METHODS: We retrospectively report, using a large series of breast abnormalities diagnosed and treated, our clinical experience on the management of the ectopic breast cancer. In 2 decades, we observed 327 (2...
August 2016: Clinical Breast Cancer
O A Egwuonwu, Snc Anyanwu, G U Chianakwana, E C Ihekwoaba
BACKGROUND: Accurate clinical diagnosis of fibroadenoma in young females is desirable because of the possibility of nonoperative treatment for those desiring it. OBJECTIVES: To determine the accuracy of the clinical diagnosis of fibroadenoma in patients aged ≤ 25 years. PATIENTS AND METHODS: A prospective study of all patients with breast disease presenting to the breast clinic was conducted from January 2004 to December 2008. RESULTS: During the study period, 145 patients aged ≤25 years presented with breast lumps...
May 2016: Nigerian Journal of Clinical Practice
Ochonma A Egwuonwu, Stanley Nc Anyanwu, Gabriel U Chianakwana, Eric C Ihekwoaba
BACKGROUND: Patients with breast pain are likely to be very worried because some consider pain in the breast as an indication of malignancy. OBJECTIVE: To highlight the causes of pain in the patients are presenting to our breast clinic. MATERIALS AND METHODS: A prospective study of all consenting patients with breast disease presenting to the breast clinic was conducted from January 2004 to December 2008. RESULTS: A total of 664 patients presented to the breast clinic during the study period...
January 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
A A Tykhomyrov, I L Vovchuk, T V Grinenko
It is known that benign breast tissue exhibit relatively low angiogenic capacity. Activation of angiogenesis in mammary pre-malignant lesions could be associated with disease progression and high risk of transformation into the breast cancer. However, insight into the underlying molecular mechanisms involved in angiogenesis regulation in non-cancerous breast pathologies is still poorly defined. The purpose of the present study was to determine levels of plasminogen and its proteolytic fragments (angiostatins) in mammary dysplasia (mastopathy and breast cyst) and benign neoplasms (fibroadenomas)...
September 2015: Ukrainian Biochemical Journal
Zhiheng Chen, Hong Guan, Hong Yuan, Xia Cao, Yingxin Liu, J I Zhou, Ellen He, Sven Skog
With regard to different types of malignancies, thymidine kinase 1 (TK1) is a useful prognostic marker in clinical oncology, both as a serum proliferation marker and in immunohistochemistry. The present study investigated the use of serum TK1 protein (STK1p) for the identification of multiple proliferating diseases linked to the risk of developing cancer, by following one patient during the period of 2003-2014. The patient presented with adenomatous polyps in the stomach in 2003, follicular cervicitis in 2007 and hyperplasia of the breast/fibrocystic breasts in 2010...
September 2015: Oncology Letters
Hongmei Zheng, Jian Chen, Xinhong Wu, Liting Jin, Chubo Qi
Fibroadenomas are a type of benign tumor that occur in young women below the age of 35 years old. The tumors are the second most common type of tumor after fibrocystic disease. The chance of carcinoma arising in a fibroadenoma is extremely low. To date, <130 such cases have been reported. Previous studies have reported that fibroadenomas can evolve into a number of different types of malignancy. The present study is the first to describe a case of bilateral primary breast cancer with a unilateral invasive ductal carcinoma within a fibroadenoma...
September 2015: Oncology Letters
Rhonda R Voskuhl, HeJing Wang, T C Jackson Wu, Nancy L Sicotte, Kunio Nakamura, Florian Kurth, Noriko Itoh, Jenny Bardens, Jacqueline T Bernard, John R Corboy, Anne H Cross, Suhayl Dhib-Jalbut, Corey C Ford, Elliot M Frohman, Barbara Giesser, Dina Jacobs, Lloyd H Kasper, Sharon Lynch, Gareth Parry, Michael K Racke, Anthony T Reder, John Rose, Dean M Wingerchuk, Allan J MacKenzie-Graham, Douglas L Arnold, Chi Hong Tseng, Robert Elashoff
BACKGROUND: Relapses of multiple sclerosis decrease during pregnancy, when the hormone estriol is increased. Estriol treatment is anti-inflammatory and neuroprotective in preclinical studies. In a small single-arm study of people with multiple sclerosis estriol reduced gadolinium-enhancing lesions and was favourably immunomodulatory. We assessed whether estriol treatment reduces multiple sclerosis relapses in women. METHODS: We did a randomised, double-blind, placebo-controlled phase 2 trial at 16 academic neurology centres in the USA, between June 28, 2007, and Jan 9, 2014...
January 2016: Lancet Neurology
Do Youn Kim, Seok Jeong Lee, Yon Ju Ryu, Jin Hwa Lee, Jung Hyun Chang, Yookyung Kim
Ankylosing spondylitis is a chronic inflammatory multisystem disease that primarily affects the axial joints. Pleuropulmonary involvement is an uncommon extra-articular manifestation of ankylosing spondylitis. There is a wide spectrum of pulmonary parenchymal changes in ankylosing spondylitis, beginning in the early stages of the disease and increasing over time. The lesions are usually asymptomatic, and not visible on chest radiographs in early stages. We reported a case of advanced ankylosing spondylitis in a 56-year-old man with progressive pulmonary bullous fibrocystic changes on both upper lobes that were misdiagnosed as tuberculosis in the early stages of the disease...
October 2015: Tuberculosis and Respiratory Diseases
Priya Subashchandrabose, Muthuvel Esakkai, Palani Venugopal, Ilavarasan Kannaiyan, Chitra Srinivasan, Punuru Tejashwini Reddy, Evelyn Elizabeth Ebenezer
Previously ectopic breast tissue was thought to be derived from the caudal remnants of the primitive embryonic milk ridges; anogenital mammary-like glands are presently considered as normal constituents of the anogenital region. We report a case of young female, who presented with an anal papilloma. Histopathological examination revealed extensive fibrocystic changes in anogenital mammary-like glands. To date, a lot of benign changes and a wide range of benign and malignant neoplasms have been reported in these glands...
2015: Case Reports in Pathology
C Sofianos, R J Zinn, D A Geoffreys, D Kruger
BACKGROUND: Preoperative, intraoperative and follow-up guidelines for managing occult carcinoma in reduction mammoplasty specimens are scant METHODS: We retrospectively analysed the records and pathology reports of 200 patients who had undergone reduction mammoplasty at two major public hospitals in Johannesburg, South Africa, during 2009-2014. Demographic data, their history of breast cancer and preoperative screening, the surgical techniques used and pathological reports were included...
April 2015: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Eujin Park, Jiwon M Lee, Yo Han Ahn, Hee Gyung Kang, I I Soo Ha, Joo Hoon Lee, Young Seo Park, Nayoung K D Kim, Woong-Yang Park, Hae Ii Cheong
BACKGROUND: Hepatorenal fibrocystic diseases (HRFCDs) are a group of monogenic disorders characterized by developmental abnormalities involving the liver and kidney. In this study, we performed genotype and phenotype analyses of children with HRFCDs to determine the distribution of underlying diseases. METHODS: A total of 36 children with HRFCDs were recruited, with genetic tests being performed in 22 patients and 14 patients diagnosed clinically as having autosomal recessive polycystic kidney disease (ARPKD)...
January 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Smita Sushil Kachewar, Suryakant Dattatraya Dongre
INTRODUCTION: Fine-needle aspiration cytology (FNAC) method is safe, reliable and time saving outdoor procedure with little discomfort to the patient for detecting Carcinoma breast. The efficacy can further be enhanced when physical breast examination, mammography and FNAC (the triple test [TT]) are jointly taken into consideration. AIMS AND OBJECTIVES: The aim was to evaluate the role of TT score (TTS) in palpable breast masses. MATERIALS AND METHODS: This prospective study was carried out from May 2010 to April 2012...
April 2015: Indian Journal of Medical and Paediatric Oncology
Adil Aljarrah, Kamran Ahmad Malik, Husam Jamil, Zoheb Jaffer, Sukhpal Sawhney, Ritu Lakhtakia
OBJECTIVES: The aim of this retrospective study was to correlate the significance and accuracy of the colour of nipple discharge and breast ultrasound imaging in the diagnosis of intraductal papilloma. METHODS: This is a retrospective study of 34 patients who underwent 36 microdochectomies in Sultan Qaboos University Hospital (SQUH) in the Sultanate of Oman, over a 4 year period of January 2009 till December 2012. The confounders considered were patient age, physical examination findings, nipple discharge cytology result, ultrasound results and biopsy report following microdochectomy...
March 2015: Pakistan Journal of Medical Sciences Quarterly
Yaqin Chen, Anthony Bekhash, Albert J Kovatich, Jeffrey A Hooke, Jianfang Liu, Leonid Kvecher, J Leigh Fantacone-Campbell, Edith P Mitchell, Hallgeir Rui, Richard J Mural, Craig D Shriver, Hai Hu
BACKGROUND: Risk assessment of a benign breast disease/lesion (BBD) for invasive breast cancer (IBC) is typically done through a longitudinal study. For an infrequently-reported BBD, the shortage of occurrence data alone is a limiting factor to conducting such a study. Here we present an approach based on co-occurrence analysis, to help address this issue. We focus on fibroadenomatoid change (FAC), an under-studied BBD, as our preliminary analysis has suggested its previously unknown significant co-occurrence with IBC...
2015: PloS One
Demetra Socolov, Ivona Anghelache, C Ilea, R Socolov, A Carauleanu
AIM: Fibrocystic mastosis (FCM) is defined by the totality of dystrophic changes of the mammary tissue, the grouping in the form of fibrosis of epithelial, cystic, metaplastic and hyperplastic alterations. A very good estimation of the cancer risk is related specifically to the microscopic aspect. Other factors, the family history as well as the presence of an inherited gene determining the increase in the risk of breast cancer are also considered. But, if a woman known with fibrocystic mastosis has not undergone any biopsy, then it is impossible to calculate the specific individual risk of developing cancer...
January 2015: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
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