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https://www.readbyqxmd.com/read/28091804/baseline-results-from-the-uk-signify-study-a-whole-body-mri-screening-study-in-tp53-mutation-carriers-and-matched-controls
#1
Sibel Saya, Emma Killick, Sarah Thomas, Natalie Taylor, Elizabeth K Bancroft, Jeanette Rothwell, Sarah Benafif, Alexander Dias, Christos Mikropoulos, Jenny Pope, Anthony Chamberlain, Ranga Gunapala, Louise Izatt, Lucy Side, Lisa Walker, Susan Tomkins, Jackie Cook, Julian Barwell, Vicki Wiles, Lauren Limb, Diana Eccles, Martin O Leach, Susan Shanley, Fiona J Gilbert, Helen Hanson, David Gallagher, Bala Rajashanker, Richard W Whitehouse, Dow-Mu Koh, S Aslam Sohaib, D Gareth Evans, Rosalind A Eeles
In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. This study sought to investigate the role of one-off non-contrast whole-body MRI (WB MRI) in the screening of asymptomatic TP53 mutation carriers. 44 TP53 mutation carriers and 44 population controls were recruited. Scans were read by radiologists blinded to participant carrier status. The incidence of malignancies diagnosed in TP53 mutation carriers against general population controls was calculated...
January 16, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28078498/perinatal-exposure-to-bisphenol-a-or-diethylstilbestrol-increases-the-susceptibility-to-develop-mammary-gland-lesions-after-estrogen-replacement-therapy-in-middle-aged-rats
#2
Ayelen L Gomez, Melisa B Delconte, Gabriela A Altamirano, Lucia Vigezzi, Veronica L Bosquiazzo, Luís F Barbisan, Jorge G Ramos, Enrique H Luque, Mónica Muñoz-de-Toro, Laura Kass
The development of the mammary gland is a hormone-regulated event. Several factors can dysregulate its growth and make the gland more susceptible to cellular transformation. Among these factors, perinatal exposure to xenoestrogens and hormone replacement therapy has been associated with increased risk of developing breast cancer. Here, we assessed the effects induced by estrogen replacement therapy (ERT) in ovariectomized (OVX) middle-aged rats and whether perinatal exposure to diethylstilbestrol (DES) or bisphenol A (BPA) modified these effects in the mammary gland...
January 11, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28031085/percutaneous-removal-of-benign-breast-lesions-with-an-ultrasound-guided-vacuum-assisted-system-influence-factors-in-the-hematoma-formation
#3
Hui-Ping Huo, Wen-Bo Wan, Zhi-Li Wang, Hong-Fei Li, Jun-Lai Li
Objective To explore the influence factors in hematoma formation after removing benign breast lesions with an ultrasound-guided vacuum-assisted system.Methods A total of 232 females with 312 benign breast masses received excisional biopsy with ultrasound- guided vacuum-assisted system. The pathology of patients, Results of hematoma development and outcome, influence factors for hematoma occurrence (nodule size, nodule location, number of nodule, breast shape, menstrual period, efficacy time of bandage, and application of hemostatic agents during the procedure) were recorded...
March 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28027762/pressure-standardised-mammography-does-not-affect-visibility-contrast-and-sharpness-of-stable-lesions
#4
J E de Groot, I G M Hopman, M G J T B van Lier, W Branderhorst, C A Grimbergen, G J den Heeten
INTRODUCTION: A recent technological development allows pressure-standardised mammography by personalizing the compression force to the breast size and firmness. The technique has been shown to reduce pain and compression variability between consecutive exams, but also results in a slightly thicker compressed breast during exposure. This raises the question whether visibility, contrast and sharpness of lesions are affected? METHODS: Four experienced radiologists compared 188 stable lesions and structures including (clusters of) calcifications, (oil) cysts and lymph nodes that were visible in mammograms obtained in 2009 with a pain-tolerance limited 18 daN target force compression protocol, and in 2014/2015 obtained with a 10kPa (75mmHg) pressure-standardised compression protocol...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/27925039/metaplastic-squamous-cell-carcinoma-of-the-breast-a-case-report-and-literature-review
#5
Luciana Graziano, Paschoal Graziano, Almir Galvão Vieira Bitencourt, Daniel Bernal Soto, Alexandre Hiro, Cíntia Camillo Nunes
Metaplastic tumors are rare and represent a heterogeneous group of neoplasms showing dominant areas of non-glandular differentiation. Etiology and pathogenesis of this type of lesion in the breast is uncertain. The most common sources of metastatic squamous cell carcinoma of the breast are lung, esophagus, cervix, and urinary bladder. Squamous cell carcinomas may present clinically with inflammation and average size greater than breast adenocarcinoma. As for imaging studies, mammography shows no typical findings and ultrasound can show a complicated cyst or an inflammatory process, among the differential diagnoses...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27922487/breast-augmentation-combining-fat-injection-and-breast-implants-in-patients-with-atrophied-breasts
#6
Burhan Özalp, Mustafa Aydinol
Breast augmentation is a challenging issue in atrophied breasts related to breastfeeding. Here, we describe a modification combining breast implants and fat grafting to obtain a successful outcome without implant edge visibility and palpability.Thirty-four women with atrophied breasts underwent breast augmentation over a 6-year period. The breast implants were placed in the subglandular plane to obtain optimal filling and expansion of atrophied breast tissue. Autologous fat grafting was performed above the inframammary sulcus to prevent implant visibility and palpability due to insufficient soft tissue coverage...
December 2, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27922452/simple-breast-cysts-should-we-treat-or-not
#7
Nuray Voyvoda
No abstract text is available yet for this article.
December 6, 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27897024/-peripheral-precocious-puberty
#8
J Zvonařová Skalická, R Pilka
OBJECTIVE: To summarize literature data on peripheral precocious puberty. DESIGN: A literature review. SETTING: Středomoravská nemocniční a.s., hospital Šternberk, Department of Obstetrics and Gynaecology, University Hospital, Medical Faculty, Palacky University, Olomouc. METHODS AND RESULTS: We searched in PubMed using the key words stated below according to date and published since 1980.Peripheral precocious puberty occurs in girls with the frequency 1:400-1000...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27869804/systemic-depletion-of-l-cyst-e-ine-with-cyst-e-inase-increases-reactive-oxygen-species-and-suppresses-tumor-growth
#9
Shira L Cramer, Achinto Saha, Jinyun Liu, Surendar Tadi, Stefano Tiziani, Wupeng Yan, Kendra Triplett, Candice Lamb, Susan E Alters, Scott Rowlinson, Yan Jessie Zhang, Michael J Keating, Peng Huang, John DiGiovanni, George Georgiou, Everett Stone
Cancer cells experience higher oxidative stress from reactive oxygen species (ROS) than do non-malignant cells because of genetic alterations and abnormal growth; as a result, maintenance of the antioxidant glutathione (GSH) is essential for their survival and proliferation. Under conditions of elevated ROS, endogenous L-cysteine (L-Cys) production is insufficient for GSH synthesis. This necessitates uptake of L-Cys that is predominantly in its disulfide form, L-cystine (CSSC), via the xCT(-) transporter. We show that administration of an engineered and pharmacologically optimized human cyst(e)inase enzyme mediates sustained depletion of the extracellular L-Cys and CSSC pool in mice and non-human primates...
January 2017: Nature Medicine
https://www.readbyqxmd.com/read/27858896/application-of-the-downgrade-criteria-to-supplemental-screening-ultrasound-for-women-with-negative-mammography-but-dense-breasts
#10
Soo-Yeon Kim, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon, Eun-Kyung Kim
We investigated whether the application of the downgrade criteria to supplemental screening ultrasound (US) for women with negative mammography but dense breasts can reduce the rate of Breast Imaging Reporting and Data System (BI-RADS) categories 3 to 4a without a loss of cancer detection.This retrospective study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. A total of 3171 consecutive women (978 women, 1173 women, and 1020 women in the first, second, and third year, respectively) with negative mammography but dense breast who underwent radiologist-performed, hand-held supplemental screening US from March 2010 to February 2013 were included...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27844217/assessing-inaccuracies-in-automated-information-extraction-of-breast-imaging-findings
#11
Ronilda Lacson, Martha E Goodrich, Kimberly Harris, Phyllis Brawarsky, Jennifer S Haas
We previously identified breast imaging findings from radiology reports using an expert-based information extraction algorithm as part of the National Cancer Institute's Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) initiative. We validate this algorithm and assess inaccuracies in a different institutional setting. Mammography, ultrasound (US), and breast magnetic resonance imaging (MRI) reports of patients at an academic health system between 4/2013 and 6/2013 were included for analysis...
November 14, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27835828/breast-cancer-and-fat-grafting-efficacy-safety-and-complications-a-systematic-review
#12
REVIEW
M De Decker, L De Schrijver, F Thiessen, T Tondu, M Van Goethem, W A Tjalma
Autologous fat grafting (AFG) or lipofilling is nowadays a popular technique for breast reconstruction after breast cancer surgery. There is debate regarding the oncological safety and risks of this procedure in breast cancer patients. A systematic review of the literature published between January first 1995 and October first 2016 was conducted regarding the efficacy, safety and complications of this technique in breast cancer patients after their cancer treatment. The databases PubMed, Science Direct and Thomson Reuters Web of Science were used to search for qualified articles...
December 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27798047/common-diseases-as-determinants-of-menopausal-age
#13
Jingmei Li, Mikael Eriksson, Kamila Czene, Per Hall, Kenny A Rodriguez-Wallberg
STUDY QUESTION: Can the diagnosis of common diseases before menopause influence age at natural menopause (ANM) onset? SUMMARY ANSWER: Polycystic ovary syndrome (PCOS) and depression were observed to delay menopause. WHAT IS KNOWN ALREADY: It has been observed that women who undergo early menopause experience a higher burden of health problems related to metabolic syndromes, heart disease and depression, but whether ANM can be influenced by common adult diseases has not been studied extensively...
December 2016: Human Reproduction
https://www.readbyqxmd.com/read/27793162/a-cost-effective-handheld-breast-scanner-for-use-in-low-resource-environments-a-validation-study
#14
Robyn B Broach, Rula Geha, Brian S Englander, Lucy DeLaCruz, Holly Thrash, Ari D Brooks
BACKGROUND: With the incidence of breast cancer rising worldwide, we are evaluating the iBreastExam (iBE) (UE LifeSciences Inc.), a handheld breast scanning device that can be utilized by community health workers to screen for breast abnormalities. The purpose of this study is to determine the sensitivity of the iBE in a population undergoing diagnostic breast imaging. METHODS: Adult patients presenting to a breast imaging center for a diagnostic workup were eligible...
October 28, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27780751/medicinal-plants-used-in-lesotho-for-treatment-of-reproductive-and-post-reproductive-problems
#15
A Moteetee, L Seleteng Kose
ETHNOPHARMACOLOGICAL RELEVANCE: Reproductive healthcare has been highlighted as a major challenge in Lesotho mainly due to the high prevalence of HIV/AIDS and sexually transmitted infections. As a result other reproductive ailments have not received much attention, particularly because healthcare facilities are already limited and many of them are inaccessible. For these reasons, medicinal plants play a major role in primary healthcare system in the country, in addition the plants are easily accessible, more affordable, and their use forms part of the cultural heritage...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27765548/metastasis-of-mammary-gland-malignant-phyllodes-tumor-to-the-mandibular-region-a-case-report-and-review-of-the-literature
#16
Sayaka Yoshiba, Takashi Saotome, Tetsuya Mikogami, Tatsuo Shirota
Phyllodes tumor is a rare breast tumor described by Müller (1938) as a lesion comprising leaflike stromal fibrous components and narrow cysts. The frequency of distant metastasis from this entity is reportedly approximately 20%, and no effective therapy has been established, so the prognosis is poor. This report describes the case of a 60-year-old woman with a history of left lung resection who showed metastasis of a mammary gland malignant phyllodes tumor to the oral cavity. Intraoral examination showed an elastic, hard mass measuring 28 × 27 mm in the gingiva around the left mandibular second molar...
September 23, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27747114/intracystic-primary-squamous-cell-carcinoma-of-the-breast-a-challenging-diagnosis
#17
Vera Ramos, João Fraga, Teresa Simões, Margarida Figueiredo Dias
We report a case of a 36-year-old woman that presented with a painful mass in the outer quadrants of the left breast that had grown rapidly. Physical examination revealed a well circumscribed elastic mass and breast ultrasound showed a cyst measuring 26 mm with vegetation growing on the inner wall. Microscopic evaluation, after fine needle aspiration cytology (FNAC), suggested benign lesion. Tumorectomy was performed and the final diagnosis was a pure squamous cell carcinoma (SCC) of the breast. A simple mastectomy with sentinel node biopsy was performed...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27733351/a-comparison-of-two-fat-grafting-methods-on-operating-room-efficiency-and-costs
#18
Allen Gabriel, G Patrick Maxwell, Leah Griffin, Manish C Champaneria, Mousam Parekh, David Macarios
BACKGROUND: Centrifugation (Cf) is a common method of fat processing but may be time consuming, especially when processing large volumes. OBJECTIVES: To determine the effects on fat grafting time, volume efficiency, reoperations, and complication rates of Cf vs an autologous fat processing system (Rv) that incorporates fat harvesting and processing in a single unit. METHODS: We performed a retrospective cohort study of consecutive patients who underwent autologous fat grafting during reconstructive breast surgery with Rv or Cf...
October 11, 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27723407/rapidly-recurring-cysts-of-the-breast-caution-needed
#19
Russell Mullen, Anne Marie Pollock, Mark Ashton, Eileen Anderson
No abstract text is available yet for this article.
October 2016: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/27723398/pilonidal-cyst-of-the-male-breast-barber-s-disease
#20
Rebecca Hughes, Fahad M Iqbal, Fathi Salem, Raghavan Vidya
No abstract text is available yet for this article.
October 2016: British Journal of Hospital Medicine
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