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https://www.readbyqxmd.com/read/28800472/phthalate-and-bisphenol-a-exposure-during-in-utero-windows-of-susceptibility-in-relation-to-reproductive-hormones-and-pubertal-development-in-girls
#1
Deborah J Watkins, Brisa N Sánchez, Martha Maria Téllez-Rojo, Joyce M Lee, Adriana Mercado-García, Clara Blank-Goldenberg, Karen E Peterson, John D Meeker
BACKGROUND: Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort...
August 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28797697/changes-in-inflammatory-endometrial-cancer-risk-biomarkers-in-individuals-undergoing-surgical-weight-loss
#2
Faina Linkov, Sharon L Goughnour, Tianzhou Ma, Zhongying Xu, Robert P Edwards, Anna E Lokshin, Ramesh C Ramanathan, Giselle G Hamad, Carol McCloskey, Dana H Bovbjerg
OBJECTIVE: Obesity has been strongly linked to endometrial cancer (EC) risk. A number of potential EC risk biomarkers have been proposed, including heightened pro-inflammatory cytokines and adipokines. To evaluate if bariatric surgery can serve as a means for altering levels of such EC risk biomarkers, we investigated changes in these biomarkers after weight loss. METHODS: Blood samples were collected pre-operatively and 6months post-operatively in 107 female bariatric surgery patients aged 18-72years...
August 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28796064/correlation-between-shbg-gene-polymorphism-and-male-infertility-in-han-population-of-henan-province-of-china-a-strobe-compliant-article
#3
Yuan-Rong Cui, Yi-Hong Guo, Su-Dong Qiao, Li-Fa Leng, Zhen-Hua Xie, Hui Chen, Xing-Ling Wang
Human sex hormone binding globulin (SHBG) level alteration and SHBG gene mutations, especially in rs6259 and rs727428 loci, are associated with male infertility. In this study, the rs6259 and rs727428 loci in SHBG gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to explore the direct relation between these 2 loci and male infertility in Han population of Henan province and to provide information for the pathogenesis, diagnosis, and treatment of male infertility...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28796060/candidate-genes-investigation-for-severe-nonalcoholic-fatty-liver-disease-based-on-bioinformatics-analysis
#4
Shan Qi, Changhong Wang, Chunfu Li, Pu Wang, Minghui Liu
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver condition worldwide. However, its etiology and fundamental pathophysiology for the disease process are poorly understood. In this study, we thus used bioinformatics to identify candidate genes potentially causative of severe NAFLD. METHODS: Gene expression profile data GSE49541 were downloaded from the Gene Expression Omnibus database. Tissues samples from 32 severe and 40 mild NAFLD patients were evaluated to identify differentially expressed genes (DEGs) between the 2 groups, followed by analyses of Gene Ontology (GO) functions and Kyoto Encyclopedia of Genes and Genomes pathways...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28780904/the-impact-of-age-bmi-and-sex-hormone-on-aging-males-symptoms-and-the-international-index-of-erectile-function-scores
#5
Xiao-Hua Yu, Jing Zhao, Shu-Cheng Zhang, Jian-Hui Li, Jun-Biao Zheng, Zheng Li, Guo-Qing Liang, Hui-Juan Shi, Wei-Jin Zhou, Qian-Xi Zhu
OBJECTIVE: To analyze the impact of age, BMI and sex hormone on aging males' symptoms (AMS) and the 5-item version of the international index of erectile function (IIEF-5) scores in middle-aged and elderly Chinese men. METHODS: A population-based cross-sectional study was conducted in Jiashan County. A total of 969 men, aged between 40 and 80 years old, were admitted. Physical examination and the sex hormones were measured, and AMS and IIEF-5 scores were assessed...
August 5, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28775186/are-thyroid-nodules-associated-with-sex-related-hormones-a-cross-sectional-spect-china-study
#6
Yi Chen, Yingchao Chen, Ningjian Wang, Chi Chen, Xiaomin Nie, Qin Li, Bing Han, Fangzhen Xia, Hualing Zhai, Boren Jiang, Zhoujun Shen, Yingli Lu
OBJECTIVE: Little is known about the association between thyroid nodules (TNs) and endogenous sex hormones. We aimed to investigate the relationship between TNs and sex-related hormones among men in China. SETTING: The data were obtained from a cross-sectional study Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China study, 2014-2015) based on the population. PARTICIPANTS: In total, 4024 men over 18 years of age who were not using hormone replacement therapy and who underwent complete assays of the serum total testosterone (T), oestradiol (E2), follicle-stimulating hormone (FSH), luteinising hormone (LH) and sex hormone-binding globulin (SHBG) levels as well as thyroid ultrasonography (US) enrolled in this study...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28753796/serum-concentrations-of-sex-hormone-binding-globulin-vary-widely-in-younger-and-older-men-clinical-data-from-a-men-s-health-practice
#7
Yonah Krakowsky, William Conners, Abraham Morgentaler
BACKGROUND: The testosterone (T) status of a man is influenced by serum concentrations of sex hormone-binding globulin (SHBG). Specifically, tight binding of T to SHBG is believed to render the SHBG-bound T fraction biologically unavailable, meaning that interpretation of T levels in the clinical setting depends in part on knowledge of SHBG concentrations. Although SHBG levels have been reported in population studies, there is scant information for men presenting with clinical symptoms...
June 3, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28723965/the-prevalence-and-metabolic-characteristics-of-polycystic-ovary-syndrome-in-the-qatari-population
#8
Soha R Dargham, Lina Ahmed, Eric S Kilpatrick, Stephen L Atkin
OBJECTIVE: The prevalence of polycystic ovary syndrome (PCOS) in the Qatari population is unknown and hence the estimated impact on the local population cannot be determined. The purpose of this study was to estimate the prevalence and metabolic features of PCOS among Qatari women. DESIGN: Cross sectional analysis. PATIENTS: 3,017 Qatari subjects volunteered to be phenotyped and genotyped for the Qatar Biobank from which all women between the ages of 18-40 years were identified (750)...
2017: PloS One
https://www.readbyqxmd.com/read/28704597/are-incident-gallstones-associated-to-sex-dependent-changes-with-age-a-cohort-study
#9
D M Shabanzadeh, S A Holmboe, L T Sørensen, A Linneberg, A-M Andersson, T Jørgensen
Age and female sex have repeatedly been identified as gallstone determinants but the underlying mechanisms are not clarified. The objectives of this study were to determine if changes with age in physiology, lifestyle, or reproductive hormones were associated with incident gallstones. A cohort study of a general population random sample (N = 2366) aged 30-60 years was performed. Participants were ultrasound screened for gallstones in 1982-84 and again in 1993-94. Lifestyle data and blood samples were obtained and re-analyzed in 2004...
July 13, 2017: Andrology
https://www.readbyqxmd.com/read/28698075/comparison-of-metformin-and-n-acetyl-cysteine-as-an-adjuvant-to-clomiphene-citrate-in-clomiphene-resistant-women-with-polycystic-ovary-syndrome
#10
M Nemati, S Nemati, A-M Taheri, B Heidari
OBJECTIVE: To evaluate the effects of short- and long-term treatment with metformin and NAC, in an adjuvant to clomiphene citrate (CC), on the improvement of hormonal profile (SHBG, total testosterone, FBS, and fasting insulin) and fertility status in CC-resistant women with PCOS. MATERIALS AND METHODS: One hundred and eight CC-resistant PCOS patients participated in the study and received either metformin (1500mg/day) or NAC (1800mg/day) with 100mg/day of CC for 8 and 12 weeks...
July 8, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28684272/androgen-profile-in-chinese-women-with-polycystic-ovary-syndrome-in-their-reproductive-years
#11
Zehong Zhou, Rong Li, Jie Qiao
Large comparative studies of androgen profiles in women with polycystic ovary syndrome (PCOS) and healthy women are scarce, and the application of the free androgen index (FAI) in diagnosing PCOS has lagged behind in China. Androgen profiles of women aged between 19 and 45 years with PCOS (n = 833) were compared with controls (n = 2732). The women with PCOS had an elevated androgen level (total testosterone, androstenedione and free androgen index) through their reproductive years. In the 'healthy' reference population (consisting of 821 controls without PCOS and without disorders affecting androgen concentrations), FAI, total testosterone and androstenedione were weakly but negatively correlated with age...
September 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28681988/effect-of-liraglutide-on-ectopic-fat-in-polycystic-ovary-syndrome-a-randomized-clinical-trial
#12
Signe Frøssing, Malin Nylander, Elizaveta Chabanova, Jan Frystyk, Jens Juul Holst, Caroline Kistorp, Sven O Skouby, Jens Faber
Women with polycystic ovary syndrome (PCOS) were treated with the GLP-1 receptor agonist liraglutide to investigate the effect on liver fat content, visceral adipose tissue (VAT), and the prevalence of nonalcoholic fatty liver disease (NAFLD). In a double-blind, placebo-controlled, randomized clinical trial 72 women with PCOS and BMI >25 kg/m(2) and/or insulin resistance were treated with liraglutide or placebo 1.8 mg/day (2:1) for 26 weeks. Liver fat content was assessed by (1) HMR spectroscopy, VAT by MRI, body composition by DXA, and glucose metabolism by oral glucose tolerance test...
July 6, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28678568/testosterone-is-associated-with-insulin-resistance-index-independently-of-adiposity-in-women-with-polycystic-ovary-syndrome
#13
Kari Luotola, Terhi T Piltonen, Johanna Puurunen, Laure C Morin-Papunen, Juha S Tapanainen
OBJECTIVE: To study the associations between androgens, glucose homeostasis, inflammation and statin treatment in women with polycystic ovary syndrome (PCOS). DESIGN AND METHODS: Oral glucose tolerance tests, androgens, hs-CRP and interleukin-1 receptor antagonist (IL-1Ra) were analyzed at baseline and after 6 months of atorvastatin (20 mg/d) or placebo treatment in 27 women with PCOS. RESULTS: Testosterone associated with insulin resistance measured with ISIMatsuda independently of BMI, age and SHBG concentrations and the full model, including IL-1Ra, hs-CRP and HDL-C, also showed independency of BMI and waist circumference (p ≤ ...
July 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28673039/a-reappraisal-of-testosterone-s-binding-in-circulation-physiological-and-clinical-implications
#14
Anna L Goldman, Shalender Bhasin, Frederick C W Wu, Meenakshi Krishna, Alvin M Matsumoto, Ravi Jasuja
In circulation, testosterone and other sex hormones are bound to binding proteins which play an important role in regulating their transport, distribution, metabolism, and biologic activity. According to the free hormone hypothesis, which has been debated extensively, only the unbound or free fraction is biologically active in target tissues. Consequently, accurate determination of the partitioning of testosterone between bound and free fractions is central to our understanding of how its delivery to the target tissues and biological activity are regulated, and, consequently, to the diagnosis and treatment of androgen disorders in men and women...
June 29, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28664912/a-combined-biomarker-panel-shows-improved-sensitivity-for-the-early-detection-of-ovarian-cancer-allowing-the-identification-of-the-most-aggressive-type-ii-tumours
#15
Matthew R Russell, Ciaren Graham, Alfonsina D'Amato, Aleksandra Gentry-Maharaj, Andy Ryan, Jatinderpal K Kalsi, Carol Ainley, Anthony D Whetton, Usha Menon, Ian Jacobs, Robert L J Graham
BACKGROUND: There is an urgent need for biomarkers for the early detection of ovarian cancer (OC). The purpose of this study was to assess whether changes in serum levels of lecithin-cholesterol acyltransferase (LCAT), sex hormone-binding globulin (SHBG), glucose-regulated protein, 78 kDa (GRP78), calprotectin and insulin-like growth factor-binding protein 2 (IGFBP2) are observed before clinical presentation and to assess the performance of these markers alone and in combination with CA125 for early detection...
June 29, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28664630/cross-sectional-association-of-coffee-and-caffeine-consumption-with-sex-hormone-binding-globulin-in-healthy-non-diabetic-women
#16
Florence Pihan-Le Bars, Gaëlle Gusto, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Fabrice Bonnet
OBJECTIVE: Low sex hormone-binding globulin (SHBG) is a consistent risk factor for type 2 diabetes, particularly in women. Coffee consumption has been associated with a lower risk of type 2 diabetes but its effects on SHBG are less known. DESIGN AND METHODS: This was a cross-sectional study of 2,377 non-diabetic pre- and post-menopausal women from the E3N cohort study whose baseline SHBG was measured. Information on diet (including coffee and caffeine consumption), lifestyle, and medical conditions was collected through questionnaires...
June 29, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28659579/sex-hormones-gonadotropins-and-sex-hormone-binding-globulin-in-infants-fed-breast-milk-cow-milk-formula-or-soy-formula
#17
Xin Fang, Lei Wang, Chunhua Wu, Huijing Shi, Zhijun Zhou, Scott Montgomery, Yang Cao
Measurement of endogenous hormones in early life is important to investigate the effects of hormonally active environmental compounds. To assess the possible hormonal effects of different feeding regimens in different sample matrices of infants, 166 infants were enrolled from two U.S hospitals between 2006 and 2009. The children were classified into exclusive soy formula, cow milk formula or breast milk regimens. Urine, saliva and blood samples were collected over the first 12 months of life. Estradiol, estrone, testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) levels were measured in the three matrices...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28657375/metabolic-effect-of-obesity-on-polycystic-ovary-syndrome-in-adolescents-a-meta-analysis
#18
Li Li, Qiong Feng, Ming Ye, Yaojuan He, Aling Yao, Kun Shi
This meta-analysis provides an updated and comprehensive estimate of the effects of obesity on metabolic disorders in adolescent polycystic ovary syndrome (PCOS). Relevant articles consistent with the search terms published up to 31 January 2014 were retrieved from PubMed, EMBASE, PsycINFO and CENTRAL. Thirteen articles (16 independent studies) conformed to the inclusion criteria. The evaluated outcomes were the metabolic parameters of obese adolescents with PCOS (case group) relative to normal-weight adolescents with PCOS, or obese adolescents without PCOS...
June 28, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28651370/changes-in-visceral-adiposity-subcutaneous-adiposity-and-sex-hormones-in-the-diabetes-prevention-program
#19
Catherine Kim, Dana Dabelea, Rita R Kalyani, Costas A Christophi, George A Bray, Xavier Pi-Sunyer, Christine H Darwin, Swaytha Yalamanchi, Elizabeth Barrett-Connor, Sherita Hill Golden, Edward J Boyko
Context: The degree to which changes in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) relate to corresponding changes in plasma sex steroids is not known. Objective: We examined whether changes in VAT and SAT areas assessed by computed tomography were associated with changes in sex hormones (dehydroepiandrosterone [DHEAS], testosterone, estradiol, estrone, and sex hormone binding globulin [SHBG]) among Diabetes Prevention Program participants...
June 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28640164/associations-between-postmenopausal-endogenous-sex-hormones-and-c-reactive-protein-a-clearer-picture-with-regional-adiposity-adjustment
#20
Shannon M Conroy, Heather K Neilson, Rachel O'Reilly, Christy G Woolcott, Frank Z Stanczyk, Kerry S Courneya, Christine M Friedenreich
OBJECTIVE: To better understand the pathogenesis of inflammatory-related diseases after menopause, we studied the adiposity-independent association between endogenous sex hormones and C-reactive protein (CRP), a biomarker of inflammation. METHODS: We conducted a secondary, cross-sectional analysis of baseline data from the Alberta Physical Activity and Breast Cancer Prevention Trial (2003-2007), including 319 healthy, postmenopausal women not using hormone therapy...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
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