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https://www.readbyqxmd.com/read/29474646/serum-levels-of-testosterone-and-shbg-in-association-with-body-mass-index-improve-the-predictive-capability-of-consolidate-tumor-biomarkers-in-pre-and-postmenopausal-breast-cancer-patients
#1
Danila Coradini, Annalisa Orenti, Elisabetta Venturelli, Adalberto Cavalleri, Elia Biganzoli, Saro Oriana
Objective: To investigate the contribution of serum levels of testosterone (TS) and sex hormone binding globulin (SHBG) in association with body mass index (BMI) as a surrogate marker of obesity, to the predictive capability of tumor size (T), lymph node (N) and estrogen receptor (ER) status and proliferative activity (TLI). Methods: We investigated 120 women with primary breast cancer and median follow-up of 138 months. Serum levels of TS and SHBG and patient's BMI were evaluated before surgery...
February 21, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29460646/sex-hormone-binding-globulin-levels-during-the-first-trimester-may-predict-gestational-diabetes-mellitus-development
#2
Tong Zhang, Tao Du, Wangen Li, Shaojuan Yang, Weiqiang Liang
AIM: To investigate the association of sex hormone-binding globulin (SHBG) levels of early pregnancy with gestational diabetes mellitus (GDM) development. METHODS: A total of 443 pregnant women during the first trimester (<12 weeks) were enrolled. SHBG levels were measured. RESULTS: SHBG level was lower in women with GDM than in women without GDM (93.9 ± 34.4 nmol/l vs 128.1 ± 60.3 nmol/l; p = 0.001). Among the four quartiles (Q1-Q4) according to SHBG levels, GDM incidences were 17...
February 20, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29457756/effects-of-combined-oral-contraceptives-on-the-clinical-and-biochemical-parameters-of-hyperandrogenism-in-patients-with-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#3
Mina Amiri, Ali Kabir, Fatemeh Nahidi, Maryam Shekofteh, Fahimeh Ramezani Tehrani
INTRODUCTION: Nowadays, selection of COCs with maximum antiandrogenic effects is one the main issues in treatment of women with polycystic ovary syndrome (PCOS). OBJECTIVE: This systematic review and meta-analysis aimed to compare the effects of COCs on the clinical and biochemical parameters of hyperandrogenism (HA) in patients with PCOS. METHODS: Electronic databases (PubMed, Scopus, ScienceDirect and web of science) were searched from 1987 to November 2015 to identify clinical trials investigating effect of the various COCs on the clinical and biochemical parameters of HA in patients...
February 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29453202/management-of-endocrine-disease-hyperandrogenic-states-in-women-pitfalls-in-laboratory-diagnosis
#4
Michel Pugeat, Ingrid Plotton, Aude Brac de la Perrière, Gerald Raverot, Henri Déchaud, Véronique Raverot
Measuring total testosterone level is the first-line approach in assessing androgen excess in women. The main pitfalls in measuring testosterone relate to its low concentration and to the structural similarity between circulating androgens and testosterone, requiring accurate techniques with high specificity and sensitivity. These goals can be achieved by immunoassay using a specific anti-testosterone monoclonal antibody, ideally after an extraction step. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) will be commonly used for measuring testosterone, providing optimal accuracy with a low limit of detection...
February 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29445518/why-do-endocrine-profiles-in-elite-athletes-differ-between-sports
#5
Peter H Sönksen, Richard I G Holt, Walailuck Böhning, Nishan Guha, David A Cowan, Christiaan Bartlett, Dankmar Böhning
Background: Endocrine profiles have been measured on blood samples obtained immediately post-competition from 693 elite athletes from 15 Olympic Sports competing at National or International level; four were subsequently excluded leaving 689 for the current analysis. Methods: Body composition was measured by bioimpedance in a sub-set of 234 (146 men and 88 women) and from these data a regression model was constructed that enabled 'estimated' lean body mass and fat mass to be calculated on all athletes...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29428305/high-molecular-weight-adiponectin-is-inversely-associated-with-sympathetic-activity-in-polycystic-ovary-syndrome
#6
Soulmaz Shorakae, Sally K Abell, Danielle S Hiam, Elisabeth A Lambert, Nina Eikelis, Eveline Jona, Carolina Ika Sari, Nigel K Stepto, Gavin W Lambert, Barbora de Courten, Helena J Teede
OBJECTIVE: To examine the role of high-molecular-weight (HMW) adiponectin and its relationship to sympathetic activity in women with polycystic ovary syndrome (PCOS). DESIGN: Cross sectional study using biobanked samples. SETTING: Not applicable. PATIENT(S): Premenopausal women with PCOS (n = 46, Rotterdam diagnostic criteria) and without PCOS (n = 22). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): High-molecular-weight adiponectin levels with secondary outcomes of sympathetic activity and leptin levels...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29421409/prenatal-exposure-to-glycol-ethers-and-sex-steroid-hormones-at-birth
#7
Charline Warembourg, Anne-Claire Binter, Frank Giton, Jean Fiet, Laurence Labat, Christine Monfort, Cécile Chevrier, Luc Multigner, Sylvaine Cordier, Ronan Garlantézec
BACKGROUND: Glycol ethers (GEs) are oxygenated solvents widely found in occupational and consumer water-based products. Some of them are well-known reproductive and developmental toxicants. OBJECTIVES: To study the variations in circulating sex steroid hormones, measured in cord blood, according to biomarkers of prenatal GE exposure. METHODS: The study population comes from the PELAGIE mother-child cohort, which enrolled pregnant women from Brittany (France, 2002-2006)...
January 31, 2018: Environment International
https://www.readbyqxmd.com/read/29408955/high-androgens-in-postmenopausal-women-and-the-risk-for-atherosclerosis-and-cardiovascular-disease-the-rotterdam-study
#8
Cindy Meun, Oscar H Franco, Klodian Dhana, Loes Jaspers, Taulant Muka, Yvonne Louwers, M Arfan Ikram, Bart C J M Fauser, Maryam Kavousi, Joop S E Laven
Context: Polycystic ovary syndrome (PCOS) is closely linked to hyperandrogenism. In PCOS, hyperandrogenism has been associated with metabolic disturbances which increase the risk for cardiovascular disease (CVD). Objective: To assess the association of high serum androgen levels, as a postmenopausal remnant of PCOS, with the prevalence of atherosclerosis and incidence of CVD in postmenopausal women. Design: The Rotterdam Study, a prospective population-based cohort study...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29405348/the-free-androgen-index-is-inaccurate-in-women-when-the-shbg-concentration-is-low
#9
Brian G Keevil, Jo Adaway, Tom Fiers, Paolo Moghetti, Jean-Marc Kaufman
OBJECTIVE/CONTEXT: The free androgen index (FAI) is known to give erroneous results in men but it is still a commonly used test for the investigation of hyperandrogenism in women. This study aimed to compare the results of the FAI with the gold standard equilibrium dialysis method for free testosterone in women. DESIGN/PATIENTS: Free serum testosterone T (ED-T) and total serum T (T) were measured by equilibrium dialysis and LC-MS/MS in patients with polycystic ovarian syndrome (n=130), normal female controls (n=53) and normal males (n=120)...
February 5, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29396841/metabolic-phenotype-of-male-obesity-related-secondary-hypogonadism-pre-replacement-and-post-replacement-therapy-with-intra-muscular-testosterone-undecanoate-therapy
#10
Georgios K Dimitriadis, Harpal S Randeva, Saboor Aftab, Asad Ali, John G Hattersley, Sarojini Pandey, Dimitris K Grammatopoulos, Georgios Valsamakis, Georgios Mastorakos, T Hugh Jones, Thomas M Barber
AIM: To explore the metabolic phenotype of obesity-related secondary hypogonadism (SH) in men pre-replacement and post-replacement therapy with long-acting intramuscular (IM) testosterone undecanoate (TU). METHODS: A prospective observational pilot study on metabolic effects of TU IM in male obesity-related SH (hypogonadal [HG] group, n = 13), including baseline comparisons with controls (eugonadal [EG] group, n = 15). Half the subjects (n = 7 in each group) had type 2 diabetes mellitus (T2D)...
February 2, 2018: Endocrine
https://www.readbyqxmd.com/read/29393043/new-determinants-for-gallstone-disease
#11
Daniel Mønsted Shabanzadeh
Gallstone disease is highly prevalent in Denmark and other countries of northern Europe, and cholecystectomy for the treatment of clinical gallstone disease is one the most frequently performed surgical procedures. Research efforts for the identification of mechanisms involved in gallstone formation have a long history and the most established include bile cholesterol saturation, gallbladder motor function, and the enterohepatic circulation of secondary bile salts produced by fecal microbiota. A small number of determinants that are believed to affect these mechanisms have been identified until now...
February 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29386084/association-analysis-of-rare-and-common-variants-with-multiple-traits-based-on-variable-reduction-method
#12
Lili Chen, Yong Wang, Yajing Zhou
Pleiotropy, the effect of one variant on multiple traits, is widespread in complex diseases. Joint analysis of multiple traits can improve statistical power to detect genetic variants and uncover the underlying genetic mechanism. Currently, a large number of existing methods target one common variant or only rare variants. Increasing evidence shows that complex diseases are caused by common and rare variants. Here we propose a region-based method to test both rare and common variant associated multiple traits based on variable reduction method (abbreviated as MULVR)...
February 1, 2018: Genetics Research
https://www.readbyqxmd.com/read/29383334/effects-of-toremifene-a-selective-estrogen-receptor-modulator-on-spontaneous-and-stimulated-gh-secretion-igf-i-and-igf-binding-proteins-in-healthy-elderly-subjects
#13
Ferdinand Roelfsema, Rebecca J Yang, Paul Y Takahashi, Dana Erickson, Cyril Y Bowers, Johannes D Veldhuis
Context: Estrogens amplify spontaneous and stimulated growth hormone (GH) secretion, whereas they diminish GH-dependent insulin-like growth factor (IGF)-I in a dose-dependent manner. Selective estrogen receptor modulators (SERMs), including tamoxifen and toremifene, are widely adjunctively used in breast and prostate cancer. Although some endocrine effects of tamoxifen are known, few data are available for toremifene. Objective: To explore sex-dependent effects of toremifene on spontaneous 10-hour overnight GH secretion, followed by GH-releasing hormone-ghrelin stimulation...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29378227/the-effect-of-acute-and-chronic-exercise-on-steroid-hormone-fluctuations-in-young-and-middle-aged-men
#14
Maha Sellami, Wissem Dhahbi, Lawrence D Hayes, Goran Kuvacic, Mirjana Milic, Johnny Padulo
The current study examine the effects of combined sprint and resistance training on serum total testosterone (TT), sex-hormone-binding globulin (SHBG) and cortisol (C), at rest, and in response to the Wingate Anaerobic-Test (WAnT) in 21 and 41years old men. Forty moderately-trained men were randomly assigned to a young trained (YT), young control (YC), middle-aged trained (MAT), and middle-aged control (MAC) group. Before (P1), and after (P2) training, blood samples were collected at rest and after exercise...
January 25, 2018: Steroids
https://www.readbyqxmd.com/read/29365335/screening-for-hypogonadism-in-primary-healthcare-how-to-do-this-effectively
#15
Mark Livingston, Richard Jones, Geoff Hackett, Gemma Donnahey, Gabriela Yc Moreno, Christopher J Duff, Adrian H Heald
BACKGROUND: Testosterone, the most important androgen produced by the testes, plays an integral role in male health. Testosterone levels are increasingly being checked in primary healthcare as awareness of the risks of male hypogonadism grows. AIM: To investigate what tests are performed to screen for hypogonadism and to exclude secondary hypogonadism. DESIGN AND SETTING: All participants attended general practices in the UK. METHODS: Data search was performed using the EMIS®: clinical database (provider of the majority of GP operating systems in Cheshire)...
January 24, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29343749/testosterone-boosts-physical-activity-in-male-mice-via-dopaminergic-pathways
#16
Ferran Jardí, Michaël R Laurent, Nari Kim, Rougin Khalil, Dimitri De Bundel, Ann Van Eeckhaut, Lawrence Van Helleputte, Ludo Deboel, Vanessa Dubois, Dieter Schollaert, Brigitte Decallonne, Geert Carmeliet, Ludo Van den Bosch, Rudi D'Hooge, Frank Claessens, Dirk Vanderschueren
Low testosterone (T) in men, especially its free fraction, has been associated with loss of energy. In accordance, orchidectomy (ORX) in rodents results in decreased physical activity. Still, the mechanisms through which T stimulates activity remain mostly obscure. Here, we studied voluntary wheel running behavior in three different mouse models of androgen deficiency: ORX, androgen receptor (AR) knock-out (ARKO) and sex hormone binding globulin (SHBG)-transgenic mice, a novel mouse model of "low free T". Our results clearly show a fast and dramatic action of T stimulating wheel running, which is not explained by its action on muscle, as evidenced by neuromuscular studies and in a muscle-specific conditional ARKO mouse model...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29336002/body-composition-and-circulating-estradiol-are-the-main-bone-density-predictors-in-healthy-young-and-middle-aged-men
#17
S C Bilha, D Branisteanu, C Buzduga, D Constantinescu, P Cianga, E Anisie, A Covic, M C Ungureanu
PURPOSE: Current fracture risk assessment options in men call for improved evaluation strategies. Recent research directed towards non-classic bone mass determinants have often yielded scarce and conflicting results. We aimed at investigating the impact of novel potential bone mass regulators together with classic determinants of bone status in healthy young and middle-aged men. METHODS: Anthropometric measurements, all-site bone mineral density (BMD) and body composition parameters assessed by dual-energy X-ray absorptiometry and also serum concentrations of (1) the adipokines leptin and resistin, (2) vitamin D and parathormone (PTH), (3) sex hormone binding globulin (SHBG), total testosterone and estradiol (free testosterone was also calculated) and (4) C-terminal telopeptide of type I collagen (CTx) were obtained from 30 apparently healthy male volunteers aged 20-65 years enrolled in this cross-sectional study...
January 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29335782/association-of-endogenous-circulating-sex-steroids-and-condition-specific-quality-of-life-domains-in-postmenopausal-women-with-pelvic-floor-disorders
#18
Barbara Bodner-Adler, Klaus Bodner, Oliver Kimberger, Ksenia Halpern, Heinz Koelbl, Wolfgang Umek
OBJECTIVE: To examine the relationship between endogenous sex steroids and various condition-specific quality of life domains in postmenopausal women with pelvic floor disorders. We hypothesized that woman with lowest androgen and estradiol concentrations would report worse scores of quality of life domains. METHODS: Forty-six women with pelvic organ prolapse (POP) and 47 cases with stress urinary incontinence (SUI) answered the validated pelvic floor questionnaire and underwent serum sex steroid measurement...
January 15, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29333510/factors-associated-with-testosterone-recovery-after-androgen-deprivation-therapy-in-patients-with-prostate-cancer
#19
Wook Nam, Se Young Choi, Sang Jun Yoo, Jeman Ryu, Jaehoon Lee, Yoon Soo Kyung, Jae Hyeon Han, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
Purpose: We investigated factors affecting testosterone recovery after androgen deprivation therapy (ADT) withdrawal in patients with prostate cancer. Materials and Methods: The medical records of patients who underwent radical prostatectomy with ADT were retrospectively reviewed. In all, 221 patients were included in the analysis. Testosterone recovery was defined as supra-castration (SC) (testosterone levels in serum >50 ng/dL) or out of hypogonadism (OH) (>300 ng/dL) after ADT withdrawal...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29330698/circulating-hormones-and-mammographic-density-in-premenopausal-women
#20
Kimberly A Bertrand, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Rulla M Tamimi
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses' Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples...
January 12, 2018: Hormones & Cancer
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