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https://www.readbyqxmd.com/read/28229170/molecular-insight-of-arsenic-induced-carcinogenesis-and-its-prevention
#1
REVIEW
Paramita Mandal
Population of India and Bangladesh and many other parts of the world are badly exposed to arsenic through drinking water. Due to non-availability of safe drinking water, they are dependent on arsenic-contaminated water. Generally, poverty level is high in those areas with lack of proper nutrition. Arsenic is considered to be an environmental contaminant and widely distributed in the environment due to its natural existence and anthropogenic applications. Contamination of arsenic in both human and animal could occur through air, soil, and other sources...
February 22, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28228764/de-novo-transcriptome-assembly-of-chinese-kale-and-global-expression-analysis-of-genes-involved-in-glucosinolate-metabolism-in-multiple-tissues
#2
Shuanghua Wu, Jianjun Lei, Guoju Chen, Hancai Chen, Bihao Cao, Changming Chen
Chinese kale, a vegetable of the cruciferous family, is a popular crop in southern China and Southeast Asia due to its high glucosinolate content and nutritional qualities. However, there is little research on the molecular genetics and genes involved in glucosinolate metabolism and its regulation in Chinese kale. In this study, we sequenced and characterized the transcriptomes and expression profiles of genes expressed in 11 tissues of Chinese kale. A total of 216 million 150-bp clean reads were generated using RNA-sequencing technology...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28218981/the-genetic-architecture-of-amino-acids-dissection-by-association-and-linkage-analysis-in-maize
#3
Min Deng, Dongqin Li, Jingyun Luo, Yingjie Xiao, Haijun Liu, Qingchun Pan, Xuehai Zhang, Minliang Jin, Mingchao Zhao, Jianbing Yan
Amino acids are both constituents of proteins, providing the essential nutrition for humans and animals, and signaling molecules regulating the growth and development of plants. Most cultivars of maize are deficient in essential amino acids such as lysine and tryptophan. Here, we measured the levels of 17 different total amino acids, and created 48 derived traits in mature kernels from a maize diversity inbred collection and three recombinant inbred line (RIL) populations. By GWAS, 247 and 281 significant loci were identified in two different environments, 5...
February 20, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28217004/rna-silencing-in-plants-mechanisms-technologies-and-applications-in-horticultural-crops
#4
Qigao Guo, Qing Liu, Neil A Smith, Guolu Liang, Ming-Bo Wang
Understanding the fundamental nature of a molecular process or a biological pathway is often a catalyst for the development of new technologies in biology. Indeed, studies from late 1990s to early 2000s have uncovered multiple overlapping but functionally distinct RNA silencing pathways in plants, including the posttranscriptional microRNA and small interfering RNA pathways and the transcriptional RNA-directed DNA methylation pathway. These findings have in turn been exploited for developing artificial RNA silencing technologies such as hairpin RNA, artificial microRNA, intrinsic direct repeat, 3' UTR inverted repeat, artificial trans-acting siRNA, and virus-induced gene silencing technologies...
December 2016: Current Genomics
https://www.readbyqxmd.com/read/28216165/isolation-and-identification-of-new-chemical-constituents-from-chinese-chive-allium-tuberosum-and-toxicological-evaluation-of-raw-and-cooked-chinese-chive
#5
Quan Gao, Xia-Bing Li, Jia Sun, Er-Dong Xia, Feng Tang, Hai-Qun Cao, Hang Xun
Chinese chive (jiu cai) is a popular vegetable in China and has a unique flavour and aroma. The molecular basis of the characteristic fragrance and nutritional properties of Chinese chive has not been previously identified. Sequential extractions in a series of solvents and high-performance liquid chromatography were used to isolate 40 compounds from Chinese chive. The compounds were identified based on high-resolution electrospray ionization mass spectra, 1D and 2D nuclear magnetic resonance techniques, and circular dichroism spectra...
February 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28214879/thiamine-deprivation-produces-a-liver-atp-deficit-and-metabolic-and-genomic-effects-in-mice-findings-are-parallel-to-those-of-biotin-deficiency-and-have-implications-for-energy-disorders
#6
Alain de J Hernandez-Vazquez, Josue Andres Garcia-Sanchez, Elizabeth Moreno-Arriola, Ana Salvador-Adriano, Daniel Ortega-Cuellar, Antonio Velazquez-Arellano
Thiamine is one of several essential cofactors for ATP generation. Its deficiency, like in beriberi and in the Wernicke-Korsakoff syndrome, has been studied for many decades. However, its mechanism of action is still not completely understood at the cellular and molecular levels. Since it acts as a coenzyme for dehydrogenases of pyruvate, branched-chain keto acids, and ketoglutarate, its nutritional privation is partly a phenocopy of inborn errors of metabolism, among them maple syrup urine disease. In the present paper, we report metabolic and genomic findings in mice deprived of thiamine...
February 18, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28213537/ketoacylsynthase-domains-of-a-pufa-synthase-in-thraustochytrium-can-effectively-function-as-stand-alone-enzymes-in-escherichia-coli
#7
Xi Xie, Dauenpen Meesapyodsuk, Xiao Qiu
Thraustochytrium sp. 26185 accumulates a high level of docosahexaenoic acid (DHA), a nutritionally important ω-3 very long chain unsaturated fatty acid (VLCPUFA) synthesized primarily by polyunsaturated fatty acid (PUFA) synthase, a Type I polyketide synthase-like mega-enzyme. The PUFA synthase in this species comprises three large subunits each with multiple catalytic domains. It was hypothesized that among these domains, ketoacylsynthase (KS) domains might be critical for catalyzing the condensation of specific unsaturated acyl-ACPs with malonyl-ACP, whereby retaining double bonds in an extended acyl chain...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28212544/protective-effect-of-dhea-on-hydrogen-peroxide-induced-oxidative-damage-and-apoptosis-in-primary-rat-leydig-cells
#8
Xiao Ding, Lei Yu, Chongyang Ge, Haitian Ma
Dehydroepiandrosterone (DHEA) is widely used as a nutritional supplement due to its putative anti-aging properties. However, the effect of DHEA in Leydig cells, a major target cell of DHEA biotransformation in male, are not clear. The present study aimed to investigate the preventative effect of DHEA on oxidative damage and apoptosis after H2O2 treatment in Leydig cells. The results showed that DHEA treatment attenuated the reduction of cell viability induced by H2O2. No differences were observed on the superoxide anion (O2-) content, while DHEA treatment decreased reactive oxygen species (ROS) and hydroxyl radical (•OH) content in H2O2-treated Leydig cells...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28208072/identification-of-triosephosphate-isomerase-as-a-novel-allergen-in-octopus-fangsiao
#9
Yang Yang, Zhong-Wei Chen, Barry K Hurlburt, Gui-Ling Li, Yong-Xia Zhang, Dan-Xia Fei, Hai-Wang Shen, Min-Jie Cao, Guang-Ming Liu
Octopus is an important mollusk in human dietary for its nutritional value, however it also causes allergic reactions in humans. Major allergens from octopus have been identified, while the knowledge of novel allergens remains poor. In the present study, a novel allergen with molecular weight of 28kDa protein was purified from octopus (Octopus fangsiao) and identified as triosephosphate isomerase (TIM) by mass spectrometry. TIM aggregated beyond 45°C, and its IgE-binding activity was affected under extreme pH conditions due to the altered secondary structure...
February 13, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28207756/structural-changes-on-a-molecular-basis-of-canola-meal-by-conditioning-temperature-and-time-during-pelleting-process-in-relation-to-physiochemical-energy-and-protein-properties-relevant-to-ruminants
#10
Xuewei Huang, Huihua Zhang, Peiqiang Yu
The objectives of this study were: (1) To investigate the effects of conditioning temperature (70, 80, 90°C), time (30, 60 sec), and interaction (temperature × time) during the pelleting process on internal protein molecular structure changes of the co-products; (2) To identify differences in protein molecular structures among pellets that were processed under different conditions, and between unprocessed mash and pellets; 3) To quantify protein molecular structure changes in relation to predicted energy and protein utilization in dairy cows...
2017: PloS One
https://www.readbyqxmd.com/read/28198810/reference-genes-for-quantitative-real-time-pcr-analysis-in-symbiont-entomomyces-delphacidicola-of-nilaparvata-lugens-st%C3%A3-l
#11
Pin-Jun Wan, Yao-Hua Tang, San-Yue Yuan, Jia-Chun He, Wei-Xia Wang, Feng-Xiang Lai, Qiang Fu
Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) is a major rice pest that harbors an endosymbiont ascomycete fungus, Entomomyces delphacidicola str. NLU (also known as yeast-like symbiont, YLS). Driving by demand of novel population management tactics (e.g. RNAi), the importance of YLS has been studied and revealed, which greatly boosts the interest of molecular level studies related to YLS. The current study focuses on reference genes for RT-qPCR studies related to YLS. Eight previously unreported YLS genes were cloned, and their expressions were evaluated for N...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194114/emerging-molecular-pathways-governing-dietary-regulation-of-neural-stem-cells-during-aging
#12
REVIEW
Chiara de Lucia, Tytus Murphy, Sandrine Thuret
Aging alters cellular and molecular processes, including those of stem cells biology. In particular, changes in neural stem cells (NSCs) are linked to cognitive decline associated with aging. Recently, the systemic environment has been shown to alter both NSCs regulation and age-related cognitive decline. Interestingly, a well-documented and naturally occurring way of altering the composition of the systemic environment is through diet and nutrition. Furthermore, it is well established that the presence of specific nutrients as well as the overall increase or reduction of calorie intake can modulate conserved molecular pathways and respectively reduce or increase lifespan...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28193581/genome-wide-characterization-and-expression-profiling-of-the-nac-genes-under-abiotic-stresses-in-cucumis-sativus
#13
Xiao Meng Zhang, Hong Jun Yu, Chao Sun, Jie Deng, Xue Zhang, Peng Liu, Yun Yun Li, Qiang Li, Wei Jie Jiang
The NAC (standing for no apical meristem [NAM], Arabidopsis transcription activation factor [ATAF] and cup-shaped cotyledon [CUC]) proteins pertain to one of the plant-specific transcription factor families that play important roles in plant development, abiotic stress resistance and signalling transduction. In the present study, the genomic features of the NAC genes in cucumber were analysed in depth using in silico tools. To reveal a tissue-specific, abiotic stress and hormone-responsive expression profile of CsNAC genes, RT-qPCR was performed under different treatments...
January 31, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28193158/transcriptional-and-physiological-analyses-of-fe-deficiency-response-in-maize-reveal-the-presence-of-strategy-i-components-and-fe-p-interactions
#14
Laura Zanin, Silvia Venuti, Anita Zamboni, Zeno Varanini, Nicola Tomasi, Roberto Pinton
BACKGROUND: Under limited iron (Fe) availability maize, a Strategy II plant, improves Fe acquisition through the release of phytosiderophores (PS) into the rhizosphere and the subsequent uptake of Fe-PS complexes into root cells. Occurrence of Strategy-I-like components and interactions with phosphorous (P) nutrition has been hypothesized based on molecular and physiological studies in grasses. RESULTS: In this report transcriptomic analysis (NimbleGen microarray) of Fe deficiency response revealed that maize roots modulated the expression levels of 724 genes (508 up- and 216 down-regulated, respectively)...
February 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28192471/the-abundance-and-diversity-of-arbuscular-mycorrhizal-fungi-are-linked-to-the-soil-chemistry-of-screes-and-to-slope-in-the-alpic-paleo-endemic-berardia-subacaulis
#15
Gabriele Casazza, Erica Lumini, Enrico Ercole, Francesco Dovana, Maria Guerrina, Annamaria Arnulfo, Luigi Minuto, Anna Fusconi, Marco Mucciarelli
Berardia subacaulis Vill. is a monospecific genus that is endemic to the South-western Alps, where it grows on alpine screes, which are extreme habitats characterized by soil disturbance and limiting growth conditions. Root colonization by arbuscular mycorrhizal fungi (AMF) is presumably of great importance in these environments, because of its positive effect on plant nutrition and stress tolerance, as well as on structuring the soil. However, there is currently a lack of information on this topic. In this paper, we tested which soil characteristics and biotic factors could contribute to determining the abundance and community composition of AMF in the roots of B...
2017: PloS One
https://www.readbyqxmd.com/read/28191562/fbpa-iron-storage-and-release-are-governed-by-periplasmic-microenvironments
#16
Ozge Sensoy, Ali Rana Atilgan, Canan Atilgan
Ferric binding protein (FbpA) is part of an elaborate iron piracy mechanism evolved in Gram-negative bacteria, shuttling iron in the periplasmic space, from the outer to the cytoplasmic membrane side. We address how the dissociation process of iron is facilitated, since the binding constant of iron is on the order of 10(18) M(-1) at 6.5 pH and 200 mM ionic strength (IS). We monitor the conformational preferences of FbpA by extensive molecular dynamics (MD) simulations under conditions where IS, charge states of iron coordinating tyrosines and pH are varied, as well as when a mutation is introduced at an allosteric site...
February 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28188053/exposure-of-portuguese-children-to-the-novel-non-phthalate-plasticizer-di-iso-nonyl-cyclohexane-1-2-dicarboxylate-dinch
#17
Luísa Correia-Sá, André Schütze, Sónia Norberto, Conceição Calhau, Valentina F Domingues, Holger M Koch
Di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH) is used as substitute for high molecular weight phthalate plasticizers such as di-(2-ethylhexyl) phthalate (DEHP) and di-(iso-nonyl) phthalate (DINP). Due to a rapid substitution process, we must assume omnipresent and increasing DINCH exposures. The aim of this study was to evaluate DINCH exposure in 112 children (4-18years old) from Portugal, divided in two groups: 1) normal-/underweight following the usual diet; and 2) obese/overweight but under strict nutritional guidance...
February 7, 2017: Environment International
https://www.readbyqxmd.com/read/28187245/molecular-phylogeny-and-ultrastructure-of-aphelidium-desmodesmi-a-new-species-in-aphelida-opisthosporidia
#18
Peter M Letcher, Martha J Powell, Philip A Lee, Salvador Lopez, Micheal Burnett
Aphelids are a diverse group of intracellular parasitoids of algae and diatoms, and are sister to true fungi. Included in four genera, the 14 described species utilize phagocytosis as their mode of nutrition, and the life cycles of these taxa are remarkably similar. However, their putative specificity of host, morphological and ultrastructural features, and genetic divergence have been considered in taxon delineation. Here we examine the host specificity, morphology, ultrastructure, and molecular 18S gene sequence of a new species in Aphelida, Aphelidium desmodesmi sp...
February 10, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28184944/exploration-of-bladder-cancer-molecular-mechanisms-based-on-mirna-mrna-regulatory-network
#19
Wenfeng Li, Jia Liu, Di Zou, Xiaye Cai, Jingying Wang, Jinmeng Wang, Li Zhu, Liang Zhao, Rongying Ou, Yunsheng Xu
To explore the complex molecular mechanisms of bladder cancer, mRNA and miRNA expression profiles were combined for systematic analyses. A total of 18 common differentially expressed genes (DEGs) were identified from two mRNA expression datasets which consisted of 206 tumor and 74 normal tissues. Then, survival analysis based on the SurvExpress database showed that the common DEGs were able to significantly differentiate low- and high-risk groups in 4 public bladder cancer datasets (p<0.01). Notably, the tumor and normal samples were able to be almost clearly classified into 4 groups based on these identified common DEGs...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28182297/cowpea-a-legume-crop-for-a-challenging-environment
#20
REVIEW
Márcia Carvalho, Teresa Lino-Neto, Eduardo Rosa, Valdemar Carnide
Cowpea is a grain legume native from Africa and is a primary source of protein for millions of people in sub-Saharan Africa and other parts of the developing world. The main important characteristics of this crop include the good protein quality with a high nutritional value, the nitrogen-fixing ability, and be more drought- and heat-tolerant than most of its legume relatives. In a research perspective, the studies with cowpea are relatively scarce, despite its relevance to agriculture in the developing world and its resilience to stress...
February 9, 2017: Journal of the Science of Food and Agriculture
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