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nutrient-gene interaction

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https://www.readbyqxmd.com/read/29339647/proceedings-of-the-11th-congress-of-the-international-society-of-nutrigenetics-and-nutrigenomics-isnn-2017
#1
William T Barrington, Anna C Salvador, Jaana A Hartiala, Raffaele De Caterina, Martin Kohlmeier, J Alfredo Martinez, Carin B Kreutzer, David Heber, Aldons J Lusis, Zhaoping Li, Hooman Allayee
The International Society of Nutrigenetics and Nutrigenomics (ISNN) held its 11th annual Congress in Los Angeles, California, between September 16 and 19, 2017. In addition to 2 keynote lectures, 4 plenary sessions included presentations by internationally renowned speakers on cutting-edge areas of research and new discoveries in genetics/genomics, the microbiome, and nutrition. Scientific topics included multi-omics approaches; diet and the microbiome; cancer, longevity, and metabolism; moving the field forward; and translational/educational aspects and the future of medicine...
January 17, 2018: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29335641/benefit-from-decline-the-primary-transcriptome-of-alteromonas-macleodii-str-te101-during-trichodesmium-demise
#2
Shengwei Hou, Mario López-Pérez, Ulrike Pfreundt, Natalia Belkin, Kurt Stüber, Bruno Huettel, Richard Reinhardt, Ilana Berman-Frank, Francisco Rodriguez-Valera, Wolfgang R Hess
Interactions between co-existing microorganisms deeply affect the physiology of the involved organisms and, ultimately, the function of the ecosystem as a whole. Copiotrophic Alteromonas are marine gammaproteobacteria that thrive during the late stages of phytoplankton blooms in the marine environment and in laboratory co-cultures with cyanobacteria such as Trichodesmium. The response of this heterotroph to the sometimes rapid and transient changes in nutrient supply when the phototroph crashes is not well understood...
January 15, 2018: ISME Journal
https://www.readbyqxmd.com/read/29335637/expression-profiling-of-host-and-virus-during-a-coccolithophore-bloom-provides-insights-into-the-role-of-viral-infection-in-promoting-carbon-export
#3
Uri Sheyn, Shilo Rosenwasser, Yoav Lehahn, Noa Barak-Gavish, Ron Rotkopf, Kay D Bidle, Ilan Koren, Daniella Schatz, Assaf Vardi
The cosmopolitan coccolithophore Emiliania huxleyi is a unicellular eukaryotic alga that forms vast blooms in the oceans impacting large biogeochemical cycles. These blooms are often terminated due to infection by the large dsDNA virus, E. huxleyi virus (EhV). It was recently established that EhV-induced modulation of E. huxleyi metabolism is a key factor for optimal viral infection cycle. Despite the huge ecological importance of this host-virus interaction, the ability to assess its spatial and temporal dynamics and its possible impact on nutrient fluxes is limited by current approaches that focus on quantification of viral abundance and biodiversity...
January 15, 2018: ISME Journal
https://www.readbyqxmd.com/read/29331071/hepatic-ppar%C3%AE-function-is-controlled-by-polyubiquitination-and-proteasome-mediated-degradation-via-the-coordinated-actions-of-paqr3-and-huwe1
#4
Zilong Zhao, Daqian Xu, Zheng Wang, Lin Wang, Ruomei Han, Zhenzhen Wang, Lujian Liao, Yan Chen
Peroxisome proliferator-activated receptor α (PPARα) is a key transcriptional factor that regulates hepatic lipid catabolism by stimulating fatty acid oxidation and ketogenesis in an adaptive response to nutrient starvation. However, how PPARα is regulated by post-translational modification is poorly understood. Here, we identified that PAQR3 promotes PPARα ubiquitination through the E3 ubiquitin ligase HUWE1, thereby negatively modulating PPARα functions both in vitro and in vivo. Adenovirus-mediated Paqr3 knockdown and liver-specific deletion of the Paqr3 gene reduced hepatic triglyceride levels while increasing fatty acid oxidation and ketogenesis upon fasting...
January 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29321537/computational-investigation-of-environment-noise-interaction-in-single-cell-organisms-the-merit-of-expression-stochasticity-depends-on-the-quality-of-environmental-fluctuations
#5
Anja Lück, Lukas Klimmasch, Peter Großmann, Sebastian Germerodt, Christoph Kaleta
Organisms need to adapt to changing environments and they do so by using a broad spectrum of strategies. These strategies include finding the right balance between expressing genes before or when they are needed, and adjusting the degree of noise inherent in gene expression. We investigated the interplay between different nutritional environments and the inhabiting organisms' metabolic and genetic adaptations by applying an evolutionary algorithm to an agent-based model of a concise bacterial metabolism. Our results show that constant environments and rapidly fluctuating environments produce similar adaptations in the organisms, making the predictability of the environment a major factor in determining optimal adaptation...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29315021/the-global-regulatory-protein-vela-is-required-for-symbiosis-between-the-endophytic-fungus-epichlo%C3%A3-festucae-and-lolium-perenne
#6
Mostafa Rahnama, Richard Johnson, Christine Rosalie Voisey, Wayne R Simpson, Damien J Fleetwood
Epichloë species fungi form bioprotective endophytic symbioses with many cool-season grasses, including agriculturally important forage grasses. Despite its importance, relatively little is known about the molecular details of the interaction and the regulatory genes involved. One of the key global regulators in fungal secondary metabolism and development is the VelA protein. In this study, velA was functionally characterised in vitro and in fungal interaction with its host perennial ryegrass. The velA gene is required for E...
January 9, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29311282/a-multimodal-strategy-used-by-a-large-c-di-gmp-network
#7
Kurt M Dahlstrom, Alan J Collins, Georgia Doing, Jaclyn N Taroni, Timothy J Gauvin, Casey S Greene, Deborah A Hogan, George A O'Toole
The Pseudomonas fluorescens genome encodes for 50+ proteins predicted to be involved in c-di-GMP signaling. Here, we demonstrate that when tested across 188 nutrients, these enzymes and effectors appear capable of impacting biofilm formation. Transcriptional analysis of network members across ∼50 nutrient conditions indicates that altered gene expression can explain a subset, but not all, of biofilm-formation responses to the nutrients. Additional organization of the network is likely achieved through physical interaction, as determined via probing ∼2000 interactions by bacterial two-hybrid assays...
January 8, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29309434/mucin-acts-as-a-nutrient-source-and-a-signal-for-the-differential-expression-of-genes-coding-for-cellular-processes-and-virulence-factors-in-acinetobacter-baumannii
#8
Emily J Ohneck, Brock A Arivett, Steven E Fiester, Cecily R Wood, Maeva L Metz, Gabriella M Simeone, Luis A Actis
The capacity of Acinetobacter baumannii to persist and cause infections depends on its interaction with abiotic and biotic surfaces, including those found on medical devices and host mucosal surfaces. However, the extracellular stimuli affecting these interactions are poorly understood. Based on our previous observations, we hypothesized that mucin, a glycoprotein secreted by lung epithelial cells, particularly during respiratory infections, significantly alters A. baumannii's physiology and its interaction with the surrounding environment...
2018: PloS One
https://www.readbyqxmd.com/read/29280555/rhizosphere-associated-alcaligenes-and-bacillus-strains-that-induce-resistance-against-blast-and-sheath-blight-diseases-enhance-plant-growth-and-improve-mineral-content-in-rice
#9
Kaleem U Kakar, Zarqa Nawaz, Zhouqi Cui, Abdulwareth A Almoneafy, Raqeeb Ullah, Qing-Yao Shu
AIMS: To examine the biocontrol activities of five rhizobacterial strains (i.e., Alcaligenes faecalis strains Bk1 and P1, Bacillus amyloliquefaciens strain Bk7, and Brevibacillus laterosporus stains B4 and S5), control the rice blast and sheath blight diseases in greenhouse, and to study their possible modes of action. METHODS AND RESULTS: Five potential plant growth promoting rhizobacterial (PGPR) strains isolated from rice rhizospheres, were tested for in vitro antifungal activities against Magnaporthe oryzae, Rhizoctonia solanii, Botrytis cinerea and Fusarium graminearum...
December 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29274982/interaction-of-starter-cultures-and-nonstarter-lactic-acid-bacteria-in-the-cheese-environment
#10
J Blaya, Z Barzideh, G LaPointe
The microbiota of ripening cheese is dominated by lactic acid bacteria, which are either added as starters and adjunct cultures or originate from the production and processing environments (nonstarter or NSLAB). After curd formation and pressing, starters reach high numbers, but their viability then decreases due to lactose depletion, salt addition, and low pH and temperature. Starter autolysis releases cellular contents, including nutrients and enzymes, into the cheese matrix. During ripening, NSLAB may attain cell densities up to 8 log cfu per g after 3 to 9 mo...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29274776/nrf2-p62-autophagy-pathway-and-its-response-to-oxidative-stress-in-hepatocellular-carcinoma
#11
REVIEW
Bartolini Desirée, Dallaglio Katiuscia, Torquato Pierangelo, Piroddi Marta, Francesco Galli
Deregulation of autophagy is proposed to play a key pathogenic role in hepatocellular carcinoma (HCC), the most common primary malignancy of the liver and the third leading cause of cancer death. Autophagy is an evolutionarily conserved catabolic process activated to degrade and recycle cell's components. Under stress conditions, such as oxidative stress and nutrient deprivation, autophagy is an essential survival pathway that operates in harmony with other stress response pathways. These include the redox-sensitive transcription complex Nrf2-Keap1 that controls groups of genes with roles in detoxification and antioxidant processes, intermediary metabolism, and cell cycle regulation...
November 29, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29261755/interaction-between-environment-nutrient-derived-metabolites-and-immunity-a-possible-role-in-malaria-susceptibility-resistance-in-fulani-and-dogon-of-mali
#12
Karim Traore, Mahamadou A Thera, Anne-Lise Bienvenu, Charles Arama, Guillaume Bonnot, Adeline Lavoignat, Ogobara K Doumbo, Stephane Picot
The role of some nutrient-derived metabolites on the innate and adaptive immune responses is now established. Global research approach investigating the interplay between environment, lifestyle and the host's immune responses is crucial in the understanding of malaria susceptibility. Advanced Glycation end products (AGE), which are food-derived metabolites result from the link between reducing sugar and amino group of proteins, lipids or nucleic acids. The level of exposure to AGEs varies depending on the type of diet...
2017: PloS One
https://www.readbyqxmd.com/read/29241564/chrysanthemum-mads-box-transcription-factor-cmanr1-modulates-lateral-root-development-via-homo-heterodimerization-to-influence-auxin-accumulation-in-arabidopsis
#13
Cui-Hui Sun, Jian-Qiang Yu, Li-Zhu Wen, Yun-Hui Guo, Xia Sun, Yu-Jin Hao, Da-Gang Hu, Cheng-Shu Zheng
Root system architecture is an important agronomic trait by which plants both acquire water and nutrients from the soil and adapt to survive in a complex environment. The adaptation of plant root systems to environmental constraints largely depends on the growth and development of lateral roots (LRs). MADS-box transcription factors (TFs) are important known regulators of plant growth, development, and response to environmental stimuli. However, the potential mechanisms by which they regulate LRs development remain poorly understood...
January 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29233944/ethylene-promotes-root-hair-growth-through-coordinated-ein3-eil1-and-rhd6-rsl1-activity-in-arabidopsis
#14
Ying Feng, Ping Xu, Bosheng Li, Pengpeng Li, Xing Wen, Fengying An, Yan Gong, Yi Xin, Ziqiang Zhu, Yichuan Wang, Hongwei Guo
Root hairs are an extensive structure of root epidermal cells and are critical for nutrient acquisition, soil anchorage, and environmental interactions in sessile plants. The phytohormone ethylene (ET) promotes root hair growth and also mediates the effects of different signals that stimulate hair cell development. However, the molecular basis of ET-induced root hair growth remains poorly understood. Here, we show that ET-activated transcription factor ETHYLENE-INSENSITIVE 3 (EIN3) physically interacts with ROOT HAIR DEFECTIVE 6 (RHD6), a well-documented positive regulator of hair cells, and that the two factors directly coactivate the hair length-determining gene RHD6-LIKE 4 (RSL4) to promote root hair elongation...
December 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29230200/from-genes-to-ecosystems-in-microbiology-modeling-approaches-and-the-importance-of-individuality
#15
REVIEW
Jan-Ulrich Kreft, Caroline M Plugge, Clara Prats, Johan H J Leveau, Weiwen Zhang, Ferdi L Hellweger
Models are important tools in microbial ecology. They can be used to advance understanding by helping to interpret observations and test hypotheses, and to predict the effects of ecosystem management actions or a different climate. Over the past decades, biological knowledge and ecosystem observations have advanced to the molecular and in particular gene level. However, microbial ecology models have changed less and a current challenge is to make them utilize the knowledge and observations at the genetic level...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29225734/pdrg1-at-the-interface-between-intermediary-metabolism-and-oncogenesis
#16
REVIEW
María Ángeles Pajares
PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damage-regulated gene 1 (PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expression has been detected in several tumor cells and in response to genotoxic stress. High-throughput studies identified the PDRG1 protein in a variety of macromolecular complexes involved in processes that are altered in cancer cells. For example, this oncogene has been found as part of the RNA polymerase II complex, the splicing machinery and nutrient sensing machinery, although its role in these complexes remains unclear...
November 26, 2017: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29215024/identification-of-srna-mediated-responses-to-nutrient-depletion-in-burkholderia-pseudomallei
#17
Hirzahida Mohd-Padil, Nadzirah Damiri, Suhaila Sulaiman, Shiao-Fei Chai, Sheila Nathan, Mohd Firdaus-Raih
The Burkholderia genus includes many species that are known to survive in diverse environmental conditions including low nutrient environments. One species, Burkholderia pseudomallei is a versatile pathogen that can survive in a wide range of hosts and environmental conditions. In this study, we investigated how a nutrient depleted growth environment evokes sRNA mediated responses by B. pseudomallei. Computationally predicted B. pseudomallei D286 sRNAs were mapped to RNA-sequencing data for cultures grown under two conditions: (1) BHIB as a nutrient rich media reference environment and (2) M9 media as a nutrient depleted stress environment...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203701/regulation-of-carbohydrate-energy-metabolism-in-drosophila-melanogaster
#18
Jaakko Mattila, Ville Hietakangas
Carbohydrate metabolism is essential for cellular energy balance as well as for the biosynthesis of new cellular building blocks. As animal nutrient intake displays temporal fluctuations and each cell type within the animal possesses specific metabolic needs, elaborate regulatory systems are needed to coordinate carbohydrate metabolism in time and space. Carbohydrate metabolism is regulated locally through gene regulatory networks and signaling pathways, which receive inputs from nutrient sensors as well as other pathways, such as developmental signals...
December 2017: Genetics
https://www.readbyqxmd.com/read/29198825/coupling-between-myogenesis-and-angiogenesis-during-skeletal-muscle-regeneration-is-stimulated-by-restorative-macrophages
#19
Claire Latroche, Michèle Weiss-Gayet, Laurent Muller, Cyril Gitiaux, Pascal Leblanc, Sophie Liot, Sabrina Ben-Larbi, Rana Abou-Khalil, Nicolas Verger, Paul Bardot, Mélanie Magnan, Fabrice Chrétien, Rémi Mounier, Stéphane Germain, Bénédicte Chazaud
In skeletal muscle, new functions for vessels have recently emerged beyond oxygen and nutrient supply, through the interactions that vascular cells establish with muscle stem cells. Here, we demonstrate in human and mouse that endothelial cells (ECs) and myogenic progenitor cells (MPCs) interacted together to couple myogenesis and angiogenesis in vitro and in vivo during skeletal muscle regeneration. Kinetics of gene expression of ECs and MPCs sorted at different time points of regeneration identified three effectors secreted by both ECs and MPCs...
December 12, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29197817/binary-culture-of-microalgae-as-an-integrated-approach-for-enhanced-biomass-and-metabolites-productivity-wastewater-treatment-and-bioflocculation
#20
REVIEW
Naim Rashid, Won-Kun Park, Thinesh Selvaratnam
Ecological studies of microalgae have revealed their potential to co-exist in the natural environment. It provides an evidence of the symbiotic relationship of microalgae with other microorganisms. The symbiosis potential of microalgae is inherited with distinct advantages, providing a venue for their scale-up applications. The deployment of large-scale microalgae applications is limited due to the technical challenges such as slow growth rate, low metabolites yield, and high risk of biomass contamination by unwanted bacteria...
November 20, 2017: Chemosphere
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