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nutrient-gene interaction

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https://www.readbyqxmd.com/read/28318006/inhibiting-the-bfrb-bfd-interaction-in-pseudomonas-aeruginosa-causes-irreversible-iron-accumulation-in-bacterioferritin-and-iron-deficiency-in-the-bacterial-cytosol
#1
Kate Eshelman, Huili Yao, Achala N D Punchi Hewage, Jacqueline J Deay, Josephine R Chandler, Mario Rivera
Iron is an essential nutrient for bacteria but the reactivity of Fe(2+) and the insolubility of Fe(3+) present significant challenges to bacterial cells. Iron storage proteins contribute to ameliorating these challenges by oxidizing Fe(2+) using O2 and H2O2 as electron acceptors, and by compartmentalizing Fe(3+). Two types of iron-storage proteins coexist in bacteria, the ferritins (Ftn) and the heme-containing bacterioferritins (Bfr), but the reasons for their coexistence are largely unknown. P. aeruginosa cells harbor two iron storage proteins (FtnA and BfrB), but nothing is known about their relative contributions to iron homeostasis...
March 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28294997/marine-prasinoviruses-and-their-tiny-plankton-hosts-a-review
#2
REVIEW
Karen D Weynberg, Michael J Allen, William H Wilson
Viruses play a crucial role in the marine environment, promoting nutrient recycling and biogeochemical cycling and driving evolutionary processes. Tiny marine phytoplankton called prasinophytes are ubiquitous and significant contributors to global primary production and biomass. A number of viruses (known as prasinoviruses) that infect these important primary producers have been isolated and characterised over the past decade. Here we review the current body of knowledge about prasinoviruses and their interactions with their algal hosts...
March 15, 2017: Viruses
https://www.readbyqxmd.com/read/28294082/genetics-of-fat-intake-in-the-determination-of-body-mass
#3
Agata Chmurzynska, Monika A Mlodzik
Body mass and fat intake are multifactorial traits that have genetic and environmental components. The gene with the greatest effect on body mass is FTO (fat mass and obesity-associated), but several studies have shown that the effect of FTO (and of other genes) on body mass can be modified by the intake of nutrients. The so-called gene-environment interactions may also be important for the effectiveness of weight-loss strategies. Food choices, and thus fat intake, depend to some extent on individual preferences...
March 15, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28293247/increase-of-fungal-pathogenicity-and-role-of-plant-glutamine-in-nitrogen-induced-susceptibility-nis-to-rice-blast
#4
Huichuan Huang, Thuy Nguyen Thi Thu, Xiahong He, Antoine Gravot, Stéphane Bernillon, Elsa Ballini, Jean-Benoit Morel
Highlight  Modifications in glutamine synthetase OsGS1-2 expression and fungal pathogenicity underlie nitrogen-induced susceptibility to rice blast. Understanding why nitrogen fertilization increase the impact of many plant diseases is of major importance. The interaction between Magnaporthe oryzae and rice was used as a model for analyzing the molecular mechanisms underlying Nitrogen-Induced Susceptibility (NIS). We show that our experimental system in which nitrogen supply strongly affects rice blast susceptibility only slightly affects plant growth...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28283524/pirated-siderophores-promote-sporulation-in-bacillus-subtilis
#5
Gabrielle M Grandchamp, Lews Caro, Elizabeth A Shank
In microbial communities bacteria chemically and physically interact with one another. Some of these interactions are mediated by secreted specialized metabolites that act as either intra- or inter-species signals to alter gene expression and change cell physiology. Bacillus subtilis is a well-characterized soil microbe that can differentiate into multiple cell types including metabolically dormant endospores. We were interested in identifying microbial interactions that affected sporulation in B. subtilis...
March 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28283521/an-amoebal-grazer-of-cyanobacteria-requires-cobalamin-produced-by-heterotrophic-bacteria
#6
Amy T Ma, Joris Beld, Bianca Brahamsha
Amoebae are unicellular eukaryotes that consume microbial prey through phagocytosis, playing a role in shaping microbial foodwebs. Many amoebal species can be cultivated axenically in rich media or monoxenically with single bacterial prey species. Here we characterize heterolobosean amoeba LPG3, a recent natural isolate, which is unable to grow on unicellular cyanobacteria, its primary food source, in the absence of a heterotrophic bacterium, a Pseudomonas species coisolate. To investigate the molecular basis of this requirement for heterotrophic bacteria, we performed a screen using a defined non-redundant transposon library of Vibrio cholerae which implicated genes in corrinoid uptake and biosynthesis...
March 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28282394/transcriptomal-profiling-of-bovine-ovarian-granulosa-and-theca-interna-cells-in-primary-culture-in-comparison-with-their-in-vivo-counterparts
#7
Nicholas Hatzirodos, Claire Glister, Katja Hummitzsch, Helen F Irving-Rodgers, Philip G Knight, Raymond J Rodgers
In vitro culture of ovarian granulosa cells and theca cells has been very important for our understanding of their function and regulation. One of the most eagerly sought attributes of cell culture is the use of chemically-defined conditions. However, even under such in vitro conditions cell behaviour could differ from the in vivo situation because of differences in oxygen tension, nutrients, adhesion matrix and other factors. To examine this further we compared the transcriptomes of both granulosa cells and cells from the theca interna that were cultured in what are arguably the best in vitro conditions for maintaining the 'follicular' phenotypes of both tissue types, as displayed by their respective freshly-isolated counterparts...
2017: PloS One
https://www.readbyqxmd.com/read/28277887/rnai-high-throughput-screening-of-single-and-multi-cell-type-tumor-spheroids-a-comprehensive-analysis-in-two-and-three-dimensions
#8
Jiaqi Fu, Daniel Fernandez, Marc Ferrer, Steven A Titus, Eugen Buehler, Madhu A Lal-Nag
The widespread use of two-dimensional (2D) monolayer cultures for high-throughput screening (HTS) to identify targets in drug discovery has led to attrition in the number of drug targets being validated. Solid tumors are complex, aberrantly growing microenvironments that harness structural components from stroma, nutrients fed through vasculature, and immunosuppressive factors. Increasing evidence of stromally-derived signaling broadens the complexity of our understanding of the tumor microenvironment while stressing the importance of developing better models that reflect these interactions...
March 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28261667/protein-malnutrition-modifies-innate-immunity-and-gene-expression-by-intestinal-epithelial-cells-and-human-rotavirus-infection-in-neonatal-gnotobiotic-pigs
#9
Anastasia N Vlasova, Francine C Paim, Sukumar Kandasamy, Moyasar A Alhamo, David D Fischer, Stephanie N Langel, Loic Deblais, Anand Kumar, Juliet Chepngeno, Lulu Shao, Huang-Chi Huang, Rosario A Candelero-Rueda, Gireesh Rajashekara, Linda J Saif
Malnutrition affects millions of children in developing countries, compromising immunity and contributing to increased rates of death from infectious diseases. Rotavirus is a major etiological agent of childhood diarrhea in developing countries, where malnutrition is prevalent. However, the interactions between the two and their combined effects on immune and intestinal functions are poorly understood. In this study, we used neonatal gnotobiotic (Gn) pigs transplanted with the fecal microbiota of a healthy 2-month-old infant (HIFM) and fed protein-deficient or -sufficient bovine milk diets...
March 2017: MSphere
https://www.readbyqxmd.com/read/28254371/the-important-functionality-of-14-3-3-isoforms-in-rice-roots-revealed-by-affinity-chromatography
#10
Zhixing Zhang, Yiping Zhang, Hong Zhao, Fenglian Huang, Zefeng Zhang, Wenxiong Lin
Plant 14-3-3 proteins belong to a large family of proteins involved in numerous physiological processes, and function by binding to phosphorylated client proteins to regulate their function. However, little is known about their regulatory mechanisms in rice root growth. In this study, four 14-3-3 isoforms (GF14b, GF14c, GF14e, GF14f) exhibiting prominent expression profiles in rice roots, were selected for further investigation. Through a pull-down assay using four 14-3-3 isoforms in rice roots, 87 client proteins were identified that are involved in metabolism, protein synthesis and trafficking, energy metabolism, cell structure and growth, and other cellular processes...
February 22, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28223530/differential-tor-activation-and-cell-proliferation-in-arabidopsis-root-and-shoot-apexes
#11
Xiaojuan Li, Wenguo Cai, Yanlin Liu, Hui Li, Liwen Fu, Zengyu Liu, Lin Xu, Hongtao Liu, Tongda Xu, Yan Xiong
The developmental plasticity of plants relies on the remarkable ability of the meristems to integrate nutrient and energy availability with environmental signals. Meristems in root and shoot apexes share highly similar molecular players but are spatially separated by soil. Whether and how these two meristematic tissues have differential activation requirements for local nutrient, hormone, and environmental cues (e.g., light) remain enigmatic in photosynthetic plants. Here, we report that the activation of root and shoot apexes relies on distinct glucose and light signals...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28221136/an-essential-dual-function-complex-mediates-erythrocyte-invasion-and-channel-mediated-nutrient-uptake-in-malaria-parasites
#12
Daisuke Ito, Marc A Schureck, Sanjay A Desai
Malaria parasites evade immune detection by growth and replication within erythrocytes. After erythrocyte invasion, the intracellular pathogen must increase host cell uptake of nutrients from plasma. Here, we report that the parasite-encoded RhopH complex contributes to both invasion and channel-mediated nutrient uptake. As rhoph2 and rhoph3 gene knockouts were not viable in the human P. falciparum pathogen, we used conditional knockdowns to determine that the encoded proteins are essential and to identify their stage-specific functions...
February 21, 2017: ELife
https://www.readbyqxmd.com/read/28220138/de-novo-transcriptome-assembly-of-phomopsis-liquidambari-provides-insights-into-genes-associated-with-different-lifestyles-in-rice-oryza-sativa-l
#13
Jun Zhou, Xin Li, Yan Chen, Chuan-Chao Dai
The mechanisms that trigger the switch from endophytic fungi to saprophytic fungi are largely unexplored. Broad host range Phomopsis liquidambari is established in endophytic and saprophytic systems with rice (Oryza sativa L.). Endophytic P. liquidambari promotes rice growth, increasing rice yield and improving the efficiency of nitrogen fertilizer. This species's saprophytic counterpart can decompose rice litterfall, promoting litter organic matter cycling and the release of nutrients and improving the soil microbial environment...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28219464/effect-of-egg-storage-duration-and-brooding-temperatures-on-chick-growth-intestine-morphology-and-nutrient-transporters
#14
S Yalcin, I Gursel, G Bilgen, B H Horuluoglu, G Gucluer, G T Izzetoglu
The effects of egg storage duration (ESD) and brooding temperature (BT) on BW, intestine development and nutrient transporters of broiler chicks were investigated. A total of 396 chicks obtained from eggs stored at 18°C for 3 days (ESD3-18°C) or at 14°C for 14 days (ESD14-14°C) before incubation were exposed to three BTs. Temperatures were initially set at 32°C, 34°C and 30°C for control (BT-Cont), high (BT-High) and low (BT-Low) BTs, respectively. Brooding temperatures were decreased by 2°C each at days 2, 7, 14 and 21...
February 21, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28215351/a-genomic-comparison-of-putative-pathogenicity-related-gene-families-in-five-members-of-the-ophiostomatales-with-different-lifestyles
#15
Ljerka Lah, Ulrike Löber, Tom Hsiang, Stefanie Hartmann
Ophiostomatoid fungi are vectored by their bark-beetle associates and colonize different host tree species. To survive and proliferate in the host, they have evolved mechanisms for detoxification and elimination of host defence compounds, efficient nutrient sequestration, and, in pathogenic species, virulence towards plants. Here, we assembled a draft genome of the spruce pathogen Ophiostoma bicolor. For our comparative and phylogenetic analyses, we mined the genomes of closely related species (Ophiostoma piceae, Ophiostoma ulmi, Ophiostoma novo-ulmi, and Grosmannia clavigera)...
March 2017: Fungal Biology
https://www.readbyqxmd.com/read/28212609/exogenous-glutamate-rapidly-induces-the-expression-of-genes-involved-in-metabolism-and-defense-responses-in-rice-roots
#16
Chia-Cheng Kan, Tsui-Yun Chung, Hsin-Yu Wu, Yan-An Juo, Ming-Hsiun Hsieh
BACKGROUND: Glutamate is an active amino acid. In addition to protein synthesis and metabolism, increasing evidence indicates that glutamate may also function as a signaling molecule in plants. Still, little is known about the nutritional role of glutamate and genes that are directly regulated by glutamate in rice. RESULTS: Exogenous glutamate could serve as a nitrogen nutrient to support the growth of rice seedlings, but it was not as effective as ammonium nitrate or glutamine...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28212431/mediterranean-dietary-pattern-and-vegf-405-g-c-gene-polymorphisms-in-patients-with-metabolic-syndrome-an-aspect-of-gene-nutrient-interaction
#17
Ghazaleh Hajiluian, Mahdieh Abbasalizad Farhangi, Leila Jahangiry
AIMS: To evaluate the relationship between Mediterranean dietary pattern, anthropometric and metabolic biomarkers and vascular endothelial growth factor (VEGF) +405 G/C gene polymorphism in patient with metabolic syndrome (Mets). MATERIALS AND METHODS: In this study 150 patients with Mets and 50 healthy subjects were enrolled. Dietary intakes were evaluated with a semi-quantitative food-frequency questionnaire (FFQ) and Mediterranean dietary quality index (Med-DQI) was assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28209137/transcriptional-analysis-of-defense-mechanisms-in-upland-tetraploid-switchgrass-to-greenbugs
#18
Teresa Donze-Reiner, Nathan A Palmer, Erin D Scully, Travis J Prochaska, Kyle G Koch, Tiffany Heng-Moss, Jeffrey D Bradshaw, Paul Twigg, Keenan Amundsen, Scott E Sattler, Gautam Sarath
BACKGROUND: Aphid infestation of switchgrass (Panicum virgatum) has the potential to reduce yields and biomass quality. Although switchgrass-greenbug (Schizaphis graminum; GB) interactions have been studied at the whole plant level, little information is available on plant defense responses at the molecular level. RESULTS: The global transcriptomic response of switchgrass cv Summer to GB was monitored by RNA-Seq in infested and control (uninfested) plants harvested at 5, 10, and 15 days after infestation (DAI)...
February 16, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28202720/interacting-tcp-and-nlp-transcription-factors-control-plant-responses-to-nitrate-availability
#19
Peizhu Guan, Juan-José Ripoll, Renhou Wang, Lam Vuong, Lindsay J Bailey-Steinitz, Dening Ye, Nigel M Crawford
Plants have evolved adaptive strategies that involve transcriptional networks to cope with and survive environmental challenges. Key transcriptional regulators that mediate responses to environmental fluctuations in nitrate have been identified; however, little is known about how these regulators interact to orchestrate nitrogen (N) responses and cell-cycle regulation. Here we report that teosinte branched1/cycloidea/proliferating cell factor1-20 (TCP20) and NIN-like protein (NLP) transcription factors NLP6 and NLP7, which act as activators of nitrate assimilatory genes, bind to adjacent sites in the upstream promoter region of the nitrate reductase gene, NIA1, and physically interact under continuous nitrate and N-starvation conditions...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28193158/transcriptional-and-physiological-analyses-of-fe-deficiency-response-in-maize-reveal-the-presence-of-strategy-i-components-and-fe-p-interactions
#20
Laura Zanin, Silvia Venuti, Anita Zamboni, Zeno Varanini, Nicola Tomasi, Roberto Pinton
BACKGROUND: Under limited iron (Fe) availability maize, a Strategy II plant, improves Fe acquisition through the release of phytosiderophores (PS) into the rhizosphere and the subsequent uptake of Fe-PS complexes into root cells. Occurrence of Strategy-I-like components and interactions with phosphorous (P) nutrition has been hypothesized based on molecular and physiological studies in grasses. RESULTS: In this report transcriptomic analysis (NimbleGen microarray) of Fe deficiency response revealed that maize roots modulated the expression levels of 724 genes (508 up- and 216 down-regulated, respectively)...
February 13, 2017: BMC Genomics
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