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https://www.readbyqxmd.com/read/27869167/cystine-addiction-of-triple-negative-breast-cancer-associated-with-emt-augmented-death-signaling
#1
X Tang, C-K Ding, J Wu, J Sjol, S Wardell, I Spasojevic, D George, D P McDonnell, D S Hsu, J T Chang, J-T Chi
Despite the advances in the diagnosis and treatment of breast cancer, breast cancers still cause significant mortality. For some patients, especially those with triple-negative breast cancer, current treatments continue to be limited and ineffective. Therefore, there remains an unmet need for a novel therapeutic approach. One potential strategy is to target the altered metabolic state that is rewired by oncogenic transformation. Specifically, this rewiring may render certain outside nutrients indispensable...
November 21, 2016: Oncogene
https://www.readbyqxmd.com/read/27771938/uv-associated-decline-in-systemic-folate-implications-for-human-nutrigenetics-health-and-evolutionary-processes
#2
Mark Lucock, Emma Beckett, Charlotte Martin, Patrice Jones, John Furst, Zoe Yates, Nina G Jablonski, George Chaplin, Martin Veysey
OBJECTIVES: The purpose of this study was to examine whether UV exposure alters folate status according to C677T-MTHFR genotype, and to consider the relevance of this to human health and the evolutionary model of skin pigmentation. METHODS: Total Ozone Mapping Spectrometer (TOMS) satellite data were used to examine surface UV-irradiance, as a marker of UV exposure, in a large (n = 649) Australian cross-sectional study population. PCR/RFLP analysis was used to genotype C677T-MTHFR...
October 22, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27721309/10th-congress-of-the-international-society-of-nutrigenetics-nutrigenomics-isnn-may-22-26-2016-tel-aviv-israel-abstracts
#3
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27629052/lunch-eating-predicts-weight-loss-effectiveness-in-carriers-of-the-common-allele-at-perilipin1-the-ontime-obesity-nutrigenetics-timing-mediterranean-study
#4
Marta Garaulet, Beatriz Vera, Gemma Bonnet-Rubio, Purificación Gómez-Abellán, Yu-Chi Lee, José M Ordovás
BACKGROUND: We propose that eating lunch late impairs the mobilization of fat from adipose tissue, particularly in carriers of PERILIPIN1 (PLIN1) variants. OBJECTIVE: The aim was to test the hypothesis that PLIN1, a circadian lipid-stabilizing protein in the adipocyte, interacts with the timing of food intake to affect weight loss. DESIGN: A total of 1287 overweight and obese subjects [229 men and 1058 women; mean ± SD body mass index (in kg/m(2)): 31 ± 5] who attended outpatient obesity clinics were enrolled in the ONTIME (Obesity, Nutrigenetics, Timing, Mediterranean) study...
October 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27467525/moving-towards-specific-nutrigenetic-recommendation-algorithms-caffeine-genetic-variation-and-cardiovascular-risk
#5
Raffaele De Caterina, Ahmed El-Sohemy
Recent research has indicated that part of the interindividual variability in cardiovascular responses to caffeine has a genetic basis. Therefore, knowledge of the individual's genetic constitution may allow an individual tailoring of dietary advice for the use of caffeine-containing beverages, yielding an example of the potential of practical translation of nutrigenetic information. This paper reviews the basis for possible nutrigenetic recommendations on the consumption of caffeine, discussing the current gaps in knowledge but also proposing a mode of action in this research area, which may be transposed to other types of similar recommendations...
July 29, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27435880/next-generation-semiconductor-based-sequencing-of-bitter-taste-receptor-genes-in-different-pig-populations-and-association-analysis-using-a-selective-dna-pool-seq-approach
#6
A Ribani, F Bertolini, G Schiavo, E Scotti, V J Utzeri, S Dall'Olio, P Trevisi, P Bosi, L Fontanesi
Taste perception in animals affects feed intake and may influence production traits. In particular, bitter is sensed by receptors encoded by the family of TAS2R genes. In this research, using a DNA pool-seq approach coupled with next generation semiconductor based target resequencing, we analysed nine porcine TAS2R genes (TAS2R1, TAS2R3, TAS2R4, TAS2R7, TAS2R9, TAS2R10, TAS2R16, TAS2R38 and TAS2R39) to identify variability and, at the same time, estimate single nucleotide polymorphism (SNP) allele frequencies in several populations and testing differences in an association analysis...
July 20, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27424010/effects-of-dha-supplementation-on-vascular-function-telomerase-activity-in-pbmc-expression-of-inflammatory-cytokines-and-ppar%C3%AE-lxr%C3%AE-abca1-pathway-in-patients-with-type-2-diabetes-mellitus-study-protocol-for-randomized-controlled-clinical-trial
#7
Omid Toupchian, Gity Sotoudeh, Anahita Mansoori, Mahmoud Djalali, Seyyed Ali Keshavarz, Ensieh Nasli-Esfahani, Ehsan Alvandi, Fariba Koohdani
Docosahexaenoic acid (DHA), as an omega-3 fatty acid, in a natural ligand of peroxisome proliferator-activated receptors (PPARs). Regarding the combinative effects of Nutrigenomics and Nutrigenetics and due to the lack of in vivo studies conducted using natural ligands of PPARs, we aimed to evaluate the effects of DHA supplementation on vascular function, telomerase activity, and PPARγ-LXRα-ABCA1 pathway, in patients with type 2 diabetes mellitus (T2DM), based on the Pro12Ala polymorphism in PPARγ encoding gene...
July 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27339810/circadian-rhythms-food-timing-and-obesity
#8
J Lopez-Minguez, P Gómez-Abellán, M Garaulet
It is known that our physiology changes throughout the day and that several physiological hormones display circadian rhythmicity. The alteration of this normal pattern is called chronodisruption (CD). In recent years, it has been demonstrated that CD is related to obesity. Although several factors may be causing CD, one important aspect to consider is the failure in our internal clock. Indeed, studies performed in mutant animals have demonstrated that mutations in clock genes are related to obesity. In human subjects, mutations are rare (<1 % of the population)...
June 24, 2016: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/27338244/interaction-between-polyphenols-intake-and-pon1-gene-variants-on-markers-of-cardiovascular-disease-a-nutrigenetic-observational-study
#9
Federica Rizzi, Costanza Conti, Elena Dogliotti, Annalisa Terranegra, Erika Salvi, Daniele Braga, Flavia Ricca, Sara Lupoli, Alessandra Mingione, Francesca Pivari, Caterina Brasacchio, Matteo Barcella, Martina Chittani, Francesca D'Avila, Maurizio Turiel, Monica Lazzaroni, Laura Soldati, Daniele Cusi, Cristina Barlassina
BACKGROUND: Paraoxonase 1 (PON1) gene polymorphisms and polyphenols intake have been reported independently associated to lipid profile and susceptibility to atherosclerosis and cardiovascular disease. However, the interaction between these factors remains to be investigated. We performed an observational nutrigenetic study to examine whether the interaction between polyphenols and anthocyanins intake and PON1 genetic variants can modulate biomarkers of cardiovascular health in an Italian healthy population...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27269202/veterinary-clinical-nutrition-success-stories-an-overview
#10
Mike Davies
In this overview of success stories in veterinary clinical nutrition topics in cats and dogs reviewed include the dietary management of chronic kidney disease, dissolution of urinary tract uroliths by dietary modification, the recognition that taurine and L-carnitine deficiencies can cause dilated cardiomyopathy; that clinical signs associated with feline hyperthyroidism (caused by a benign adenoma) can be controlled by a low-iodine diet alone; that dietary management of canine osteoarthritis can also reduce non-steroidal anti-inflammatory drug doses; and that disease-free intervals and survival times can be statistically longer in dogs with Stage III lymphoma managed with diet...
August 2016: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/27236593/precision-obesity-treatments-including-pharmacogenetic-and-nutrigenetic-approaches
#11
REVIEW
Maite Solas, Fermin I Milagro, Diego Martínez-Urbistondo, Maria J Ramirez, J Alfredo Martínez
Five pharmaceutical strategies are currently approved by the US FDA for the treatment of obesity: orlistat, lorcaserin, liraglutide, phentermine/topiramate, and bupropion/naltrexone. The most effective treatment seems to be the combined administration of phentermine/topiramate followed by lorcaserin and bupropion/naltrexone. In relation to the management of excessive weight, other aspects also need to be considered, including comorbidities accompanying obesity, drug interactions, and the risk of negative collateral effects, as well as individualized treatments based on the genetic make-up...
July 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27215437/a-novel-approach-to-the-nutrigenetics-and-nutrigenomics-of-obesity-and-weight-management
#12
REVIEW
Yael T Joffe, Christine A Houghton
Nutrigenetics and nutrigenomics, as well as diet and exercise, play an important role in the development and treatment of obesity and its comorbidities. If an individual's susceptibility to becoming obese and their responsiveness to weight loss interventions are to be understood, then it needs to be addressed at a molecular and metabolic level, including genetic interaction. This review proposes a three-pillar approach to more fully comprehend the complexity of diet-gene interactions in obesity. Peroxisomal proliferating-activated receptor gamma (PPARG) and mitochondrial uncoupling protein-1 (UCP-1) are explored in detail...
July 2016: Current Oncology Reports
https://www.readbyqxmd.com/read/27182816/factors-associated-with-the-intention-of-registered-dietitians-to-discuss-nutrigenetics-with-their-patients-clients
#13
Annie Bouchard-Mercier, Sophie Desroches, Julie Robitaille, Marie-Claude Vohl
PURPOSE: The objective of this study was to investigate factors affecting the intention of Registered Dietitians (RDs) to discuss nutrigenetics with their patients/clients. METHODS: A survey based on the theory of planned behaviour (TPB; attitude, subjective norm, and perceived behavioural control) was developed and sent by email to RD members of the Ordre professionnel des diététistes du Québec. Multiple regression analyses were performed to examine the determinants of intention and behaviour...
May 16, 2016: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/27169401/guide-and-position-of-the-international-society-of-nutrigenetics-nutrigenomics-on-personalised-nutrition-part-1-fields-of-precision-nutrition
#14
Lynnette R Ferguson, Raffaele De Caterina, Ulf Görman, Hooman Allayee, Martin Kohlmeier, Chandan Prasad, Myung Sook Choi, Rui Curi, Daniel Antonio de Luis, Ángel Gil, Jing X Kang, Ron L Martin, Fermin I Milagro, Carolina Ferreira Nicoletti, Carla Barbosa Nonino, Jose Maria Ordovas, Virginia R Parslow, María P Portillo, José Luis Santos, Charles N Serhan, Artemis P Simopoulos, Antonio Velázquez-Arellano, Maria Angeles Zulet, J Alfredo Martinez
Diversity in the genetic profile between individuals and specific ethnic groups affects nutrient requirements, metabolism and response to nutritional and dietary interventions. Indeed, individuals respond differently to lifestyle interventions (diet, physical activity, smoking, etc.). The sequencing of the human genome and subsequent increased knowledge regarding human genetic variation is contributing to the emergence of personalized nutrition. These advances in genetic science are raising numerous questions regarding the mode that precision nutrition can contribute solutions to emerging problems in public health, by reducing the risk and prevalence of nutrition-related diseases...
2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27095829/nutrigenomics-the-microbiome-and-gene-environment-interactions-new-directions-in-cardiovascular-disease-research-prevention-and-treatment-a-scientific-statement-from-the-american-heart-association
#15
Jane F Ferguson, Hooman Allayee, Robert E Gerszten, Folami Ideraabdullah, Penny M Kris-Etherton, José M Ordovás, Eric B Rimm, Thomas J Wang, Brian J Bennett
Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome...
June 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/26962191/future-perspectives-of-personalized-weight-loss-interventions-based-on-nutrigenetic-epigenetic-and-metagenomic-data
#16
Leticia Goni, Marta Cuervo, Fermín I Milagro, J Alfredo Martínez
As obesity has become a major global public health challenge, a large number of studies have analyzed different strategies aimed at inducing a negative energy balance and, consequently, body weight loss. However, most existing weight loss programs are generally unsuccessful, so several interventions have been carried out to identify physiologic and behavioral factors concerning this variability in order to implement more personalized treatment. Nowadays, an individualized approach is being proposed through so-called personalized nutrition, whereby not only the phenotype but also the genotype is used for customized nutrition treatment...
March 9, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/26927084/nutrigenetics-and-nutrimiromics-of-the-circadian-system-the-time-for-human-health
#17
REVIEW
Víctor Micó, Laura Díez-Ricote, Lidia Daimiel
Even though the rhythmic oscillations of life have long been known, the precise molecular mechanisms of the biological clock are only recently being explored. Circadian rhythms are found in virtually all organisms and affect our lives. Thus, it is not surprising that the correct running of this clock is essential for cellular functions and health. The circadian system is composed of an intricate network of genes interwined in an intrincated transcriptional/translational feedback loop. The precise oscillation of this clock is controlled by the circadian genes that, in turn, regulate the circadian oscillations of many cellular pathways...
February 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26881038/sulforaphane-and-other-nutrigenomic-nrf2-activators-can-the-clinician-s-expectation-be-matched-by-the-reality
#18
REVIEW
Christine A Houghton, Robert G Fassett, Jeff S Coombes
The recognition that food-derived nonnutrient molecules can modulate gene expression to influence intracellular molecular mechanisms has seen the emergence of the fields of nutrigenomics and nutrigenetics. The aim of this review is to describe the properties of nutrigenomic activators of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), comparing the potential for sulforaphane and other phytochemicals to demonstrate clinical efficacy as complementary medicines. Broccoli-derived sulforaphane emerges as a phytochemical with this capability, with oral doses capable of favourably modifying genes associated with chemoprevention...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26833124/cystine-deprivation-triggers-programmed-necrosis-in-vhl-deficient-renal-cell-carcinomas
#19
Xiaohu Tang, Jianli Wu, Chien-Kuang Ding, Min Lu, Melissa M Keenan, Chao-Chieh Lin, Chih-An Lin, Charles C Wang, Daniel George, David S Hsu, Jen-Tsan Chi
Oncogenic transformation may reprogram tumor metabolism and render cancer cells addicted to extracellular nutrients. Deprivation of these nutrients may therefore represent a therapeutic opportunity, but predicting which nutrients cancer cells become addicted remains difficult. Here, we performed a nutrigenetic screen to determine the phenotypes of isogenic pairs of clear cell renal cancer cells (ccRCC), with or without VHL, upon the deprivation of individual amino acids. We found that cystine deprivation triggered rapid programmed necrosis in VHL-deficient cell lines and primary ccRCC tumor cells, but not in VHL-restored counterparts...
April 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/26759364/dietary-rescue-of-altered-metabolism-gene-reveals-unexpected-drosophila-mating-cues
#20
François Bousquet, Isabelle Chauvel, Justin Flaven-Pouchon, Jean-Pierre Farine, Jean-François Ferveur
To develop and reproduce, animals need long-chain MUFAs and PUFAs. Although some unsaturated FAs (UFAs) can be synthesized by the organism, others must be provided by the diet. The gene, desat1, involved in Drosophila melanogaster UFA metabolism, is necessary for both larval development and for adult sex pheromone communication. We first characterized desat1 expression in larval tissues. Then, we found that larvae in which desat1 expression was knocked down throughout development died during the larval stages when raised on standard food...
March 2016: Journal of Lipid Research
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