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https://www.readbyqxmd.com/read/27899442/early-generated-b1-b-cells-with-restricted-bcrs-become-chronic-lymphocytic-leukemia-with-continued-c-myc-and-low-bmf-expression
#1
Kyoko Hayakawa, Anthony M Formica, Joni Brill-Dashoff, Susan A Shinton, Daiju Ichikawa, Yan Zhou, Herbert C Morse, Richard R Hardy
In mice, generation of autoreactive CD5(+) B cells occurs as a consequence of BCR signaling induced by (self)-ligand exposure from fetal/neonatal B-1 B cell development. A fraction of these cells self-renew and persist as a minor B1 B cell subset throughout life. Here, we show that transfer of early generated B1 B cells from Eμ-TCL1 transgenic mice resulted in chronic lymphocytic leukemia (CLL) with a biased repertoire, including stereotyped BCRs. Thus, B1 B cells bearing restricted BCRs can become CLL during aging...
November 29, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27896786/construction-of-efficient-streptococcus-zooepidemicus-strains-for-hyaluoronic-acid-production-based-on-identification-of-key-genes-involved-in-sucrose-metabolism
#2
Xuzhen Zhang, Man Wang, Tuanjie Li, Lixia Fu, Wei Cao, Hao Liu
Biosynthesis of polysaccharide hyaluoronic acid (HA) by Streptococcus zooepidemicus is a carbon-intensive process. The carbon flux and factor(s) restricting HA yield were not well understood. Here, we investigated the function of genes involved in sucrose metabolism and identified targets limiting HA yield, which were exploited to construct efficient S. zooepidemicus strains for HA production. The sucrose uptake was addressed by deletion of scrA and scrB, which encodes sucrose-PTS permease and sucrose-6-phosphate hydrolase, respectively...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27836719/effects-of-the-dietary-supplementation-of-mixed-probiotic-spores-of-bacillus-amyloliquefaciens-54a-and-bacillus-pumilus-47b-on-growth-innate-immunity-and-stress-responses-of-striped-catfish-pangasianodon-hypophthalmus
#3
Ho Thi Truong Thy, Nguyen Nhu Tri, Ong Moc Quy, Korntip Kannika, Sasimanas Unajak, Nontawith Areechon
The study used the mixed probiotics of Bacillus amyloliquefaciens 54A and B. pumilus 47B isolated from striped catfish (Pangasianodon hypophthalmus) intestine aiming to stimulate growth performance, innate immunity, stress tolerance of striped catfish. The average weight gain (AWG), specific growth rate (SGR), and feed conversion ratio (FCR) were analyzed after fish were fed the mixture of probiotics (B. amyloliquefaciens 54A and B. pumilus 47B) at concentrations of 1 × 10(8), 3 × 10(8), and 5 × 10(8) CFU g(-1) feed for 90 days...
November 8, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27830546/thy-1-cd90-positive-hepatic-progenitor-cells-hepatoctyes-and-non-parenchymal-liver-cells-isolated-from-human-livers
#4
Thomas S Weiss, Rania Dayoub
In response to liver injury, hepatic cells, especially hepatocytes, can rapidly proliferate to repair liver damage. Additionally, it was shown that under certain circumstances liver resident cells with progenitor capabilities are involved in liver cell proliferation and differentiation. These hepatic progenitor cells (HPCs), known as oval cells in rodents, are derived from the canals of Hering, which are located in the periportal region of the liver. Regarding to different cell niches, which were defined for human HPCs, several markers have been used to identify these cells such as CD34, c-kit, OV-6, and Thy-1 (CD90)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27818384/hippocampal-t-cell-infiltration-promotes-neuroinflammation-and-cognitive-decline-in-a-mouse-model-of-tauopathy
#5
Cyril Laurent, Guillaume Dorothée, Stéphane Hunot, Elodie Martin, Yann Monnet, Marie Duchamp, Yuan Dong, François-Pierre Légeron, Antoine Leboucher, Sylvie Burnouf, Emilie Faivre, Kévin Carvalho, Raphaëlle Caillierez, Nadège Zommer, Dominique Demeyer, Nathalie Jouy, Veronique Sazdovitch, Susanna Schraen-Maschke, Cécile Delarasse, Luc Buée, David Blum
Alzheimer's disease is characterized by the combined presence of amyloid plaques and tau pathology, the latter being correlated with the progression of clinical symptoms. Neuroinflammatory changes are thought to be major contributors to Alzheimer's disease pathophysiology, even if their precise role still remains largely debated. Notably, to what extent immune responses contribute to cognitive impairments promoted by tau pathology remains poorly understood. To address this question, we took advantage of the THY-Tau22 mouse model that progressively develops hippocampal tau pathology paralleling cognitive deficits and reappraised the interrelationship between tau pathology and brain immune responses...
November 5, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27814753/facility-level-ckd-mbd-composite-score-and-risk-of-adverse-clinical-outcomes-among-patients-on-hemodialysis
#6
Geoffrey A Block, Akeem A Yusuf, Mark D Danese, Heidi S Wirtz, Yan Hu, Thy P Do, Kerry Cooper, David T Gilbertson, Brian D Bradbury, Allan J Collins
BACKGROUND: Patients receiving hemodialysis with values outside of target levels for parathyroid hormone (PTH: 150-600 pg/mL), calcium (Ca: 8.4-10.2 mg/dL), and phosphate (P: 3.5-5.5 mg/dL) are at elevated morbidity and mortality risk. We examined whether patients receiving care in dialysis facilities where greater proportions of patients have at least two values out of target have a higher risk of adverse clinical outcomes. METHODS: The study cohort consisted of 39,085 prevalent hemodialysis patients in 1298 DaVita dialysis facilities as of September 1, 2009, followed from January 1, 2010, until an outcome, a censoring event, or December 31, 2010...
November 4, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27809694/low-elasticity-of-thyroid-nodules-at-ultrasound-elastography-is-correlated-with-malignancy-degree-of-fibrosis-and-high-expression-of-galectin-3-and-fibronectin-1
#7
Teresa Rago, Maria Scutari, Valeria Loiacono, Ferruccio Santini, Massimo Tonacchera, Liborio Torregrossa, Riccardo Giannini, Nicla Borrelli, Agnese Proietti, Fulvio Basolo, Paolo Miccoli, Paolo Piaggi, Francesco Latrofa, Paolo Vitti
BACKGROUND: Thyroid ultrasound elastography (US elastography) provides an estimation of tissue stiffness and is helpful to differentiate malignant from benign lesions. Tissue proprieties and molecules causing stiffness are not established. The aim of the study was to correlate US elastography findings with tissue properties in thyroid nodules. METHODS: 115 thyroid nodules from 112 patients who underwent surgery for the presence of of Thy 3 (indeterminate) cytology (n=67), Thy 4-5 (suspicious-indicative of carcinoma) cytology (n= 47) or large goiter in the presence of Thy 2 cytology (n= 1) and suspicious US features were examined by US elastography...
November 3, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27802110/base-release-and-modification-in-solid-phase-dna-exposed-to-low-energy-electrons
#8
Surakarn Choofong, Pierre Cloutier, Léon Sanche, J Richard Wagner
Ionization generates a large number of secondary low-energy electrons (LEEs) with a most probable energy of approximately 10 eV, which can break DNA bonds by dissociative electron attachment (DEA) and lead to DNA damage. In this study, we investigated radiation damage to dry DNA induced by X rays (1.5 keV) alone on a glass substrate or X rays combined with extra LEEs (average energy of 5.8 eV) emitted from a tantalum (Ta) substrate under an atmosphere of N2 and standard ambient conditions of temperature and pressure...
November 1, 2016: Radiation Research
https://www.readbyqxmd.com/read/27799744/%C3%AE-aminoadipic-acid-protects-against-retinal-disruption-through-attenuating-m%C3%A3-ller-cell-gliosis-in-a-rat-model-of-acute-ocular-hypertension
#9
Xiaolei Wang, Jier Su, Jingwen Ding, Song Han, Wei Ma, Hong Luo, Guy Hughes, Zhaoyang Meng, Yi Yin, Yanling Wang, Junfa Li
OBJECTIVE: Ocular hypertension is an important risk factor for glaucoma. The purpose of this study was to investigate the gliotoxic effects of α-aminoadipic acid (AAA) in a rat model of AOH and its underlying mechanisms. MATERIALS AND METHODS: In the rat model of acute ocular hypertension (AOH), intraocular pressure was increased to 110 mmHg for 60 minutes. Animals were divided into four groups: sham operation (Ctrl), AOH, AOH + phosphate-buffered saline (PBS), and AOH + AAA...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27785414/von-recklinghausen-disease-one-patient-various-problems
#10
B Bergler-Czop, B Miziołek, L Brzezińska-Wcisło
von Recklinghausen disease (vRD), more widely known as neurofibromatosis type 1, belongs to a group of genetic disorders and it is considered to be the most common genodermatosis. The disease has an autosomal dominant pattern of inheritance that involves mutations within the NF1 gene located on chromosome 17 in locus q11.2. The product of the NF1 gene is neurofibromin and the protein is well known to be a tumor suppressor factor. This counteracts possible overactivity of RAS (protein)/MAPK (mitogen-activated protein kinase) and RAS/PI3K/AKT/mTOR (phoshatydyloinositol-3-kinase/V-akt murine thy-moma viral oncogene homologue/mammalian target of rapamycin) signaling transduction pathways, preventing from uncontrolled cell proliferation and subsequent tumor formation...
July 1, 2016: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/27768790/thy-1-regulates-vegf-mediated-choroidal-endothelial-cell-activation-and-migration-implications-in-neovascular-age-related-macular-degeneration
#11
Haibo Wang, Xiaokun Han, Eric Kunz, M Elizabeth Hartnett
Purpose: This study addresses the hypothesis that age-related stresses upregulate Thy-1 in choroidal endothelial cells (CECs) and contribute to CEC activation and migration, processes important in choroidal neovascularization (CNV). Methods: Measurements were made of Thy-1 protein (Western blot) in CECs and Thy-1 mRNA (real time quantitative PCR) in CECs treated with VEGF, CCL11, or PBS or in RPE/choroids from young or old donors or lasered or nonlasered mice. Immunolabeled Thy-1 in ocular sections was compared from young versus old human donor eyes or those with or without neovascular AMD or from lasered versus nonlasered mice...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27743026/soluble-phospho-tau-from-alzheimer-s-disease-hippocampus-drives-microglial-degeneration
#12
Elisabeth Sanchez-Mejias, Victoria Navarro, Sebastian Jimenez, Maria Sanchez-Mico, Raquel Sanchez-Varo, Cristina Nuñez-Diaz, Laura Trujillo-Estrada, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica
The role of microglial cells in the development and progression of Alzheimer's disease (AD) has not been elucidated. Here, we demonstrated the existence of a weak microglial response in human AD hippocampus which is in contrast to the massive microglial activation observed in APP-based models. Most importantly, microglial cells displayed a prominent degenerative profile (dentate gyrus > CA3 > CA1 > parahippocampal gyrus), including fragmented and dystrophic processes with spheroids, a reduced numerical density, and a significant decrease in the area of surveillance ("microglial domain")...
December 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27737362/expression-of-cd90-and-p75ntr-stem-cell-markers-in-ameloblastomas-a-possible-role-in-their-biological-behavior
#13
Fernanda Paula Yamamoto Silva, Andrielle Dias, Carolinne Almeida Coelho, Eliete Neves Guerra, Ana Elizia Mascarenhas Marques, Daniel de Almeida Decurcio, Andrea Mantesso, Sérgio Elias Vieira Cury, Brunno Santos de Freitas Silva
Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these cells in tumor growth, angiogenesis, progression, infiltration and invasiveness. This study evaluated the immunohistochemical expression of CD90(Thy-1) and P75NTR stem cell markers in multicystic and unicystic ameloblastomas. Seventeen (17) samples of ameloblastomas (multicystic, n = 10; unicystic, n = 7) were submitted to immunohistochemical reactions and graded semi-quantitatively...
October 10, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27723565/tribenzyltin-carboxylates-as-anticancer-drug-candidates-effect-on-the-cytotoxicity-motility-and-invasiveness-of-breast-cancer-cell-lines
#14
Theebaa Anasamy, Chun Keng Thy, Kong Mun Lo, Chin Fei Chee, Swee Keong Yeap, Behnam Kamalidehghan, Lip Yong Chung
This study seeks to investigate the relationship between the structural modification and bioactivity of a series of tribenzyltin complexes with different ligands and substitutions. Complexation with the N,N-diisopropylcarbamothioylsulfanylacetate or isonicotinate ligands enhanced the anticancer properties of tribenzyltin compounds via delayed cancer cell-cycle progression, caspase-dependent apoptosis induction, and significant reduction in cell motility, migration and invasion. Halogenation of the benzyl ring improved the anticancer effects of the tribenzyltin compounds with the N,N-diisopropylcarbamothioylsulfanylacetate ligand...
September 21, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27723092/in-situ-enhancement-of-surfactin-biosynthesis-in-bacillus-subtilis-using-novel-artificial-inducible-promoters
#15
Song Jiao, Xu Li, Huimin Yu, Huan Yang, Xue Li, Zhongyao Shen
Surfactin-family lipopeptides are green biosurfactants with substantial industrial potential. The major problem prohibiting surfactin use is the low titer of the wild producer, Bacillus subtilis. Using transcriptomic analysis, four strong promoters, PgroE, Pcdd, PrplK, and PsspE, were identified and cloned from the genome of B. subtilis THY-7, a novel surfactin producer that has been identified from soil with a 0.55 g/L surfactin titer. An optimal promoter, PgroE, was selected to replace the native THY-7 surfactin synthase (SrfA) promoter through single-cross homologous recombination; however, the resulting engineered strain containing the PgroE substitution did not synthesize surfactin...
October 10, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27701125/the-use-of-bovine-collagen-glycosaminoglycan-matrix-for-atypical-lower-extremity-ulcers
#16
Caitlin S Garwood, Paul J Kim, Vinay Matai, John S Steinberg, Karen K Evans, Carol Deane B Mitnick, Christopher E Attinger
The primary purpose of this study was to evaluate the use of bovine collagen-glycosaminoglycan matrix on atypical lower extremity ulcers. A retrospective chart review was performed on patients who underwent application of bovine collagen matrix to a lower extremity ulcer with an atypical etiology including autoimmune disease, sickle cell anemia, radiation therapy, connective tissue disease, vasculitis, or coagulopathy from January 2009 to October 2014. The following outcomes were evaluated: rate of ulcer healing and closure, number of ulcers that received a split-thickness skin graft, improvement in pain, and complications related to the ulcer...
September 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27671162/early-onset-pediatric-atopic-dermatitis-is-th2-but-also-th17-polarized-in-skin
#17
Hitokazu Esaki, Patrick M Brunner, Yael Renert-Yuval, Tali Czarnowicki, Thy Huynh, Gary Tran, Sarah Lyon, Giselle Rodriguez, Supriya Immaneni, Donald B Johnson, Bruce Bauer, Judilyn Fuentes-Duculan, Xiuzhong Zheng, Xiangyu Peng, Yeriel D Estrada, Hui Xu, Christina de Guzman Strong, Mayte Suárez-Fariñas, James G Krueger, Amy S Paller, Emma Guttman-Yassky
BACKGROUND: Atopic dermatitis (AD) affects 15% to 25% of children and 4% to 7% of adults. Paradigm-shifting discoveries about AD have been based on adult biomarkers, reflecting decades of disease activity, although 85% of cases begin by 5 years. Blood phenotyping shows only TH2 skewing in patients with early-onset pediatric AD, but alterations in early pediatric skin lesions are unknown, limiting advancement of targeted therapies. OBJECTIVE: We sought to characterize the early pediatric AD skin phenotype and its differences from pediatric control subjects and adults with AD...
September 15, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27651248/spices-potential-therapeutics-for-alzheimer-s-disease
#18
N Satheeshkumar, R S K Vijayan, A Lingesh, S Santhikumar, Ch Vishnuvardhan
India has traditionally been known to all over the world for spices and medicinal plants. Spices exhibit a wide range of pharmacological activities. In contemporary, Indian spices are used to rustle up delicious delicacies. However, the Indian spices are more than just adjuvant which adds aroma and fragrance to foods. A few spices are very widely used and grown commercially in many countries, contain many important chemical constituents in the form of essential oil, oleoresin, oleogum, and resins, which impart flavor, pungency, and color to the prepared dishes, simultaneously exerts diverse therapeutic benefits...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27617027/chi-ju-di-huang-wan-protects-rats-against-retinal-ischemia-by-downregulating-matrix-metalloproteinase-9-and-inhibiting-p38-mitogen-activated-protein-kinase
#19
Hsiao-Ming Chao, Lei Hu, Ji-Min Cheng, Xiao-Qian Liu, Jorn-Hon Liu, Wynn Hwai-Tzong Pan, Xiu-Mei Zhang
BACKGROUND: Retinal ischemia is a retinal disorder related to retinal vascular occlusion, glaucoma, diabetic retinopathy and age-related macular degeneration. The study aimed to evaluate the protective effects and underlying mechanisms of Chi-Ju-Di-Huang-Wan (CJDHW) against retinal ischemia in rats. METHODS: High intraocular pressure (HIOP)-induced retinal ischemia was established in Wistar rats by raising their intraocular pressure to 120 mmHg for 60 min with in an eye whose anterior chamber was cannulated with a 30-guage needle adapted to a normal saline bottle through an intravenous line...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27583546/c5a-induces-the-synthesis-of-il-6-and-tnf-%C3%AE-in-rat-glomerular-mesangial-cells-through-mapk-signaling-pathways
#20
Mingde Ji, Yanlai Lu, Chenhui Zhao, Wenxing Gao, Fengxia He, Jing Zhang, Dan Zhao, Wen Qiu, Yingwei Wang
Inflammatory response has been reported to contribute to the renal lesions in rat Thy-1 nephritis (Thy-1N) as an animal model of human mesangioproliferative glomerulonephritis (MsPGN). Besides C5b-9 complex, C5a is also a potent pro-inflammatory mediator and correlated to severity of various nephritic diseases. However, the role of C5a in mediating pro-inflammatory cytokine production in rats with Thy-1N is poorly defined. In the present studies, the levels of C5a, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were first determined in the renal tissues of rats with Thy-1N...
2016: PloS One
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