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https://www.readbyqxmd.com/read/28633498/thymol-as-natural-antioxidant-additive-for-poultry-feed-oxidative-stability-improvement
#1
A Luna, R C Lema-Alba, J S Dambolena, J A Zygadlo, M C Labaque, R H Marin
Antioxidant are regularly included in poultry feed as protection from deterioration during storage. Recently the interest for the use of natural phytochemicals in animal diets has been increased. Thymol (THY) has been proven to be an effective antioxidant for extending broiler meat quality during storage with similar action to the widely used butylated hydroxytoluene (BHT). This study evaluates whether THY can also have a protective effect on the feed mash by assessing its antioxidant potential and related changes in fatty acid (FA) balance...
June 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28585223/a-molecular-tweezer-ameliorates-motor-deficits-in-mice-overexpressing-%C3%AE-synuclein
#2
Franziska Richter, Sudhakar R Subramaniam, Iddo Magen, Patrick Lee, Jane Hayes, Aida Attar, Chunni Zhu, Nicholas R Franich, Nicholas Bove, Krystal De La Rosa, Jacky Kwong, Frank-Gerrit Klärner, Thomas Schrader, Marie-Françoise Chesselet, Gal Bitan
Aberrant accumulation and self-assembly of α-synuclein are tightly linked to several neurodegenerative diseases called synucleinopathies, including idiopathic Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Deposition of fibrillar α-synuclein as insoluble inclusions in affected brain cells is a pathological hallmark of synucleinopathies. However, water-soluble α-synuclein oligomers may be the actual culprits causing neuronal dysfunction and degeneration in synucleinopathies. Accordingly, therapeutic approaches targeting the toxic α-synuclein assemblies are attractive for these incurable disorders...
June 5, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28551987/terbium-iii-luminescent-complexes-as-millisecond-scale-viscosity-probes-for-lifetime-imaging
#3
Anh Thy Bui, Alexei Grichine, Alain Duperray, Pierre Lidon, François Riobé, Chantal Andraud, Olivier Maury
Fluorescent probes that are able to directly measure viscosity are attractive candidates for the study of intracellular environments. We report a new class of luminescent rotors, based on the sensitized emission of a terbium(III) complex. A 4-fold increase in both quantum yield and luminescence lifetime was observed in viscous media for the studied complexes, with a lifetime ranging from 0.23 to 0.89 ms over a broad range of viscosities (0.6-1200 cP). The presented approach, relying on the millisecond-scale luminescence lifetime of the lanthanide ions, was applied to fixed T24 cancer cells using temporal sampling lifetime imaging microscopy...
May 31, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28550098/contralesional-brain-computer-interface-control-of-a-powered-exoskeleton-for-motor-recovery-in-chronic-stroke-survivors
#4
David T Bundy, Lauren Souders, Kelly Baranyai, Laura Leonard, Gerwin Schalk, Robert Coker, Daniel W Moran, Thy Huskey, Eric C Leuthardt
BACKGROUND AND PURPOSE: There are few effective therapies to achieve functional recovery from motor-related disabilities affecting the upper limb after stroke. This feasibility study tested whether a powered exoskeleton driven by a brain-computer interface (BCI), using neural activity from the unaffected cortical hemisphere, could affect motor recovery in chronic hemiparetic stroke survivors. This novel system was designed and configured for a home-based setting to test the feasibility of BCI-driven neurorehabilitation in outpatient environments...
May 26, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28530556/antibacterial-electrospun-zein-nanofibrous-web-encapsulating-thymol-cyclodextrin-inclusion-complex-for-food-packaging
#5
Zeynep Aytac, Semran Ipek, Engin Durgun, Turgay Tekinay, Tamer Uyar
Thymol (THY)/γ-Cyclodextrin(γ-CD) inclusion complex (IC) encapsulated electrospun zein nanofibrous webs (zein-THY/γ-CD-IC-NF) were fabricated as a food packaging material. The formation of THY/γ-CD-IC (1:1 and 2:1) was proved by experimental (X-ray diffraction (XRD), thermal gravimetric analysis (TGA), (1)H NMR) and computational techniques. THY/γ-CD-IC (2:1) exhibited higher preservation rate and stability than THY/γ-CD-IC (1:1). It is worth mentioning that zein-THY/γ-CD-IC-NF (2:1) preserved much more THY as observed in TGA and stability of THY/γ-CD-IC (2:1) was higher, as shown by a modelling study...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28516180/near-infrared-two-photon-imaging-using-a-bright-cationic-yb-iii-bioprobe-spontaneously-internalized-into-live-cells
#6
Anh Thy Bui, Maryline Beyler, Alexei Grichine, Alain Duperray, Jean-Christophe Mulatier, Yannick Guyot, Chantal Andraud, Raphaël Tripier, Sophie Brasselet, Olivier Maury
An Yb(iii) complex based on a dimethyl cyclen macrocyclic ligand functionalized by charge transfer antennae was prepared. This cationic [YbL3](+) complex is stable and soluble in water and presents interesting photophysical nonlinear properties. It is spontaneously internalized and accumulates in live cells. High quality images have been obtained both in a classical NIR-to-vis configuration and in the more challenging NIR-to-NIR one.
May 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28491462/understanding-microstructure-of-the-brain-by-comparison-of-neurite-orientation-dispersion-and-density-imaging-noddi-with-transparent-mouse-brain
#7
Kanako Sato, Aurelien Kerever, Koji Kamagata, Kohei Tsuruta, Ryusuke Irie, Kazuhiko Tagawa, Hitoshi Okazawa, Eri Arikawa-Hirasawa, Nobuhiro Nitta, Ichio Aoki, Shigeki Aoki
BACKGROUND: Neurite orientation dispersion and density imaging (NODDI) is a diffusion magnetic resonance imaging (MRI) technique with the potential to visualize the microstructure of the brain. Revolutionary histological methods to render the mouse brain transparent have recently been developed, but verification of NODDI by these methods has not been reported. PURPOSE: To confirm the concordance of NODDI with histology in terms of density and orientation dispersion of neurites of the brain...
April 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28482862/higher-levels-of-myelin-phospholipids-in-brains-of-neuronal-%C3%AE-synuclein-transgenic-mice-precede-myelin-loss
#8
Jessica Grigoletto, Katharina Pukaß, Ayelet Gamliel, Dana Davidi, Rachel Katz-Brull, Christiane Richter-Landsberg, Ronit Sharon
α-Synuclein is a protein involved in the pathogenesis of synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). We investigated the role of neuronal α-Syn in myelin composition and abnormalities. The phospholipid content of purified myelin was determined by (31)P NMR in two mouse lines modeling PD, PrP-A53T α-Syn and Thy-1 wt-α-Syn. Significantly higher levels of phospholipids were detected in myelin purified from brains of these α-Syn transgenic mouse models than in control mice...
May 8, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28479933/the-potential-of-enriched-mesenchymal-stem-cells-with-neural-crest-cell-phenotypes-as-a-cell-source-for-regenerative-dentistry
#9
REVIEW
Kunimichi Niibe, Maolin Zhang, Kosuke Nakazawa, Satoru Morikawa, Taneaki Nakagawa, Yumi Matsuzaki, Hiroshi Egusa
Effective regenerative treatments for periodontal tissue defects have recently been demonstrated using mesenchymal stromal/stem cells (MSCs). Furthermore, current bioengineering techniques have enabled de novo fabrication of tooth-perio dental units in mice. These cutting-edge technologies are expected to address unmet needs within regenerative dentistry. However, to achieve efficient and stable treatment outcomes, preparation of an appropriate stem cell source is essential. Many researchers are investigating the use of adult stem cells for regenerative dentistry; bone marrow-derived MSCs (BM-MSCs) are particularly promising and presently used clinically...
May 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28474397/thymol-feed-supplementation-in-quail-alters-the-percentages-of-nutritionally-relevant-egg-yolk-fatty-acids-effects-throughout-incubation
#10
Maria E Fernandez, Raul H Marin, Agustin Luna, Maria P Zunino, Maria C Labaque
BACKGROUND: PUFA are crucial components of the yolk and particularly prone to oxidative damage generating losses of nutrients for embryonic development and influencing the quality of eggs for human consumption. We evaluated whether dietary thymol (a natural antioxidant) is related to changes in quail egg yolk total, triglycerides and phospholipids fatty acid composition (T, TG, PL, respectively) at different stages of embryo development. Thus, female Japanese quail (100d) were assigned to 1 of 2 dietary treatments (12 individuals each): CON (basal diet) or THY (0...
May 5, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28397613/know-thy-self-know-thy-enemy-a-current-survey-and-a-forecast-for-kpc-producing-klebsiella-pneumoniae-resistance-among-inpatients-in-southern-brazil
#11
Leandro Reus Rodrigues Perez
No abstract text is available yet for this article.
April 11, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28390315/glutathione-inhibits-antibody-and-complement-mediated-immunologic-cell-injury-via-multiple-mechanisms
#12
Zhen Zhang, Xiling Zhang, Xin Fang, Manabu Niimi, Yanru Huang, Honglan Piao, Shan Gao, Jianglin Fan, Jian Yao
Antioxidant glutathione (GSH) plays an important role in the regulation of immunity. However, little is known about its effects on humoral immunity, especially its action on effector molecules like antibody and complement. Given that these molecules contain abundant disulfide bonds, we speculated that GSH might influence the action of these proteins via its thiol function. Using a model of a glomerular mesangial cell (MC) lysis induced by antibodies plus complement, we addressed this hypothesis. Exposure of rat MCs to anti-Thy-1 antibody plus complement or anti-MC rabbit serum caused a complement-dependent cell lysis, which was completely blocked by GSH...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28347277/-let-food-be-thy-medicine%C3%A2-lessons-from-low-protein-diets-from-around-the-world
#13
EDITORIAL
Giorgina B Piccoli, Adamasco Cupisti
In this editorial we present the special issue dedicated to low-protein diets (LPDs) in chronic kidney disease, from a global perspective.The experiences gathered from several countries across all continents have created an issue which we hope you will find insightful, and lead to further discussion on this interesting topic.We discover that LPDs are feasible in both developed and low income countries, in patients where literacy is an issue, and are also safe, including during pregnancy and in old age.Patients prescribed a low protein diet are more inclined to follow and adhere to this change in lifestyle, provided the diet has been adapted to meet their own individual needs...
March 27, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28341839/therapeutic-efficacy-of-neural-stem-cells-originating-from-umbilical-cord-derived-mesenchymal-stem-cells-in-diabetic-retinopathy
#14
Wei Zhang, Yuexin Wang, Jiahui Kong, Meng Dong, Hongtao Duan, Song Chen
The aim of this study was to evaluate the effects of intravitreal injection of neural stem cells (NSCs) originating from human umbilical cord-derived mesenchymal stem cells (UC-MSCs) on neurodegeneration of diabetic retinopathy (DR) in rats. UC-MSCs were isolated and passaged, followed by induction to NSCs in neural differentiation medium. Four weeks following NSC transplantation, treatment attenuated retinal vascular dysfunction compared with non-treated rats, and BDNF and Thy-1 expression was significantly higher in the treated group than in the control group...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331445/negligible-oval-cell-proliferation-following-ischemia-reperfusion-injury-with-and-without-partial-hepatectomy
#15
Ek Khoon Tan, Maureen Shuh, Heather Francois-Vaughan, Jennifer A Sanders, Ari J Cohen
BACKGROUND: Hepatic oval cells proliferate to replace hepatocytes and restore liver function when hepatocyte proliferation is compromised or inadequate. Exposure to chemical carcinogens, severe liver steatosis, and partial hepatectomy has been used in animal models to demonstrate the role of oval cells in liver regeneration. Ischemia-reperfusion injury (IRI) causes hepatocellular damage and death in the absence of confounding chemical toxicity; however, oval cell induction by IRI has not been demonstrated in vivo...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28329658/potential-relationship-between-rosacea-and-parkinson-s-disease
#16
Erin Ibler, Beatrice Nardone, Sara Majewski, Nicholas Guido, Thy Huynh, Sarah Lyon, Stephanie M Rangel, Bethanee Schlosser, Dennis P West, Anne E Laumann
Rosacea is a common inflammatory condition characterized by transient or persistent facial erythema, telangiectasias, papules and pustules, for which an association has been reported to exist with Parkinson's disease (PD). We used a large, urban, single center, electronic medical record repository by searching the Northwestern Medicine Enterprise Data Warehouse (NMEDW) (> 4 million patients) for this association. Patients were included if they had an in-person encounter (Jan 2001 to May 2016) and with 1 year documentation of follow-up...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28327348/know-thy-agency-in-predictive-coding-meta-monitoring-over-forward-modeling
#17
Tomohisa Asai
Though the computation of agency is thought to be based on prediction error, it is important for us to grasp our own reliability of that detected error. Here, the current study shows that we have a meta-monitoring ability over our own forward model, where the accuracy of motor prediction and therefore of the felt agency are implicitly evaluated. Healthy participants (N=105) conducted a simple motor control task and SELF or OTHER visual feedback was given. The relationship between the accuracy and confidence in a mismatch detection task and in a self-other attribution task was examined...
April 10, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28327005/to-sleep-perchance-to-dream
#18
Jane Bates
'Ne'er the good counsel of thy nurse despise; forsooth! Instil these drops into thine eyes. Not thrice but four times, as the hours do run, from the day's break to the setting of the sun.'
March 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28325116/stem-cell-markers-describe-a-transition-from-somatic-to-pluripotent-cell-states-in-a-rat-model-of-endometriosis
#19
Essam Rashad Othman, Fatma Yassine Meligy, Ayat Abdel-Rahman Sayed, Mohamed Ahmed El-Mokhtar, Abeer Mohamed Refaiy
OBJECTIVE: To study Thy1 as a fibroblast marker, SSEA1 as a marker of intermediate pluripotency, and Oct4 as a marker of established pluripotency in rat model of endometriosis. DESIGN: In vivo animal study. MATERIALS AND METHODS: Endometriosis was induced in 20 albino female rats through autologous transplantation of one uterine horn to mesentery of intestine. Other 20 rats had their horn removed without transplantation (controls). Rats were sacrificed 4 weeks after induction surgery...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28321780/isolation-culture-and-identification-of-pulmonary-arterial-smooth-muscle-cells-from-rat-distal-pulmonary-arteries
#20
Gongyong Peng, Juan Xu, Rongmin Liu, Zhenli Fu, Shaoxing Li, Wei Hong, Jinglong Chen, Bing Li, Pixin Ran
The culture of pulmonary arterial smooth muscle cells (PASMCs) is one of the most powerful tools for exploring the mechanisms of pulmonary hypertension (PH). Both pulmonary vasoconstriction and remodeling occur predominantly in distal pulmonary arteries (PA). In this study, we provide our detailed and standardized protocol for easy isolation and culture of PASMCs from rat distal PA to supply every investigator with a simple, economical and useful method in studying PH. The protocol can be divided into four stages: isolation of distal PA, isolation of cells, growth in culture and passage of cells...
March 21, 2017: Cytotechnology
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