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https://www.readbyqxmd.com/read/28818326/dual-wavelength-led-based-uv-absorption-detector-for-nano-flow-capillary-liquid-chromatography
#1
Xiaofeng Xie, Luke T Tolley, Thy X Truong, H Dennis Tolley, Paul B Farnsworth, Milton L Lee
The design of a miniaturized LED-based UV-absorption detector was significantly improved for on-column nanoflow LC. The detector measures approximately 27mm×24mm×10mm and weighs only 30g. Detection limits down to the nanomolar range and linearity across 3 orders of magnitude were obtained using sodium anthraquinone-2-sulfonate as a test analyte. Using two miniaturized detectors, a dual-detector system was assembled containing 255nm and 275nm LEDs with only 216nL volume between the detectors A 100μm slit was used for on-column detection with a 150μm i...
August 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28812052/the-superior-labial-frenulum-in-newborns-what-is-normal
#2
Chloe Santa Maria, Janelle Aby, Mai Thy Trong, Yogita Thakur, Sharon Rea, Anna Messner
Introduction and Objectives: There has been an emergence of procedures to release the superior labial frenula in infants, yet little is known about the normal appearance or incidence of severe attachment, or "lip-tie." The objective of this article was to develop a classification system for superior labial frenula and to estimate the incidence of different degrees of attachment. Methods: A prospective cross-sectional study. Newborns were examined and had photographs taken of their upper frenula. Relevant medical professionals rated the appearance of the labial frenula using a previously described Kotlow classification system...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28745444/comparison-of-the-proteomes-of-mouse-skin-derived-precursors-skps-and-skp-derived-fibroblasts-sfbs-by-itraq
#3
Yujie Mao, Lidan Xiong, Li Li
Skin-derived precursors (SKPs) can differentiate into fibroblasts. However, little is known about the molecular mechanism of the differentiation process. Our previous study has compared the transcriptomes of mouse SKPs and SKP- derived fibroblasts (SFBs) by RNA-Seq analysis and found some genes and signal pathways that might play important roles in the transition from SKPs to SFBs. Here, to further investigate the process by which SKPs differentiate into fibroblasts, we compared the proteomes between SKPs and SFBs using iTRAQ...
July 26, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28744021/thy-1-cancer-associated-fibroblasts-adversely-impact-lung-cancer-prognosis
#4
Mark J Schliekelman, Chad J Creighton, Brandi N Baird, Yulong Chen, Priyam Banerjee, Neus Bota-Rabassedas, Young-Ho Ahn, Jonathon D Roybal, Fengju Chen, Yiqun Zhang, Dhruva K Mishra, Min P Kim, Xin Liu, Barbara Mino, Pamela Villalobos, Jaime Rodriguez-Canales, Carmen Behrens, Ignacio I Wistuba, Samir M Hanash, Jonathan M Kurie
Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the clinical outcome of lung cancer patients have not been fully elucidated. Because Thy-1 (CD90) marks CAFs that promote tumor cell invasion in a murine model of Kras(G12D)-driven lung adenocarcinoma (Kras(LA1)), here we postulated that human lung adenocarcinomas containing Thy-1(+) CAFs have a worse prognosis. We first examined the location of Thy-1(+) CAFs within human lung adenocarcinomas...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28734306/theoretical-study-of-resonance-formation-in-microhydrated-molecules-ii-thymine-h2o-n-n-1-2-3-5
#5
Agnieszka Sieradzka, Jimena D Gorfinkiel
We have investigated the effect of microsolvation on the low-lying pure shape π(*) resonances of thymine. Static-exchange R-matrix calculations for elastic electron scattering from microhydated thymine, i.e., Thy-(H2O)n with n = 1,2,3,5 are discussed. We look at the additive effect of water molecules hydrogen-bonding to thymine. The results for Thy-(H2O)5 show that both π(*) resonances appear at lower energy in the cluster than in isolated thymine, but that the energy shift is different for each resonance...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28724609/thy-1-fibroblast-subsets-in-the-human-peritoneum
#6
Edyta Kawka, Janusz Witowski, Maria Bartosova, Rusan Catar, Andras Rudolf, Aurelie Philippe, Rafal Rutkowski, Betti Schaefer, Claus Peter Schmitt, Duska Dragun, Achim Joerres
Fibrotic thickening of the peritoneum develops in patients receiving peritoneal dialysis (PD) for renal failure. For unknown reasons, however, in some patients it progresses to extensive fibrosis that compromises dialysis capacity of the peritoneum. It is increasingly clear that fibroblasts display large heterogeneity not only between but also within tissues. Differential surface expression of glycoprotein Thy-1 (CD90) has been shown to identify functionally distinct fibroblast subsets in several organs. Here, we isolated Thy-1+/- subsets of human peritoneal fibroblasts (HPFB) and analyzed them in terms of pro-fibrotic myofibroblast features...
July 19, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28722074/supramolecular-semifluorinated-dendrons-glued-by-weak-hydrogen-bonds
#7
Senbin Chen, Annette Meister, Wolfgang H Binder
H-Bonded semifluorinated dendritic polymer networks are generated by association of macromolecules, driven by the weak diaminopyridine (DAP) and thymine (THY) couple. Solvent-dependent morphologies are observed: a continuous film structure when drop-cast from tetrahydrofuran (THF) solution or uniform nanoparticles with a diameter of ∼50 nm in toluene.
July 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28718205/bcl-2-maturation-pattern-in-t-cells-distinguishes-thymic-neoplasm-hyperplasia-t-lymphoblastic-lymphoma-and-reactive-lymph-nodes
#8
Nicholas Ward, Junaid Baqai, Alexandra Zehnpfennig, Nancy Fine, James Huang, Marc D Smith
Anterior mediastinal biopsies consisting predominantly of small lymphocytes can be a diagnostic challenge, especially in small core biopsies. In these cases, immunophenotyping is often employed using flow cytometry, and/or immunohistochemistry. However, due the overlap in T-cell phenotype between thymic neoplasm/hyperplasia (THY), T lymphoblastic lymphoma (T-LBL) and reactive lymph nodes (RLN), biopsies consisting predominantly of T-cells may still be difficult to differentiate. Previous studies have shown a specific CD3/bcl-2 staining pattern in thymic T cells of humans and mice using flow cytometry...
July 17, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28717059/pharmacological-effects-of-a-vitamin-k1-2-3-epoxide-reductase-vkor-inhibitor-3-acetyl-5-methyltetronic-acid-on-cisplatin-induced-fibrosis-in-rats
#9
Masashi Uchida, Tomoya Miyoshi, Yohei Miyamoto
Cisplatin (CDDP) is a chemotherapeutic agent that is widely used in the treatment of lymphomas and solid malignancies. However, its clinical usage is limited by its severe side effects in the kidneys. Glomerular and tubular injuries in the kidneys commonly progress to interstitial fibrosis and, ultimately, the end stage of renal failure. We previously reported that 3-acetyl-5-methyltetronic acid (AMT) had inhibitory effects on rat renal vitamin K1 2,3-epoxide reductase (VKOR) in vitro and also suppressed mesangial cell proliferation and, consequently, the formation of fibrosis via the vitamin K-dependent activation of the growth arrest-specific 6 (Gas6)/Axl pathway in anti-Thy-1 glomerulonephritis (Thy-1 GN) in rats...
July 16, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28695756/double-carbapenem-therapy-dct-for-bacteremia-due-to-carbapenem-resistant-klebsiella-pneumoniae-crkp-from-test-tube-to-clinical-practice
#10
Veena Venugopalan, Boris Nogid, Thy N Le, Shafiqur M Rahman, Tiffany E Bias
No abstract text is available yet for this article.
July 11, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28681580/retrospective-cytological-evaluation-of-indeterminate-thyroid-nodules-according-to-the-british-thyroid-association-2014-classification-and-comparison-of-clinical-evaluation-and-outcomes
#11
Massimo Giusti, Barbara Massa, Margherita Balestra, Paola Calamaro, Stefano Gay, Simone Schiaffino, Giovanni Turtulici, Simonetta Zupo, Eleonora Monti, Gianluca Ansaldo
The cytology of 130 indeterminate nodules (Thy 3) was retrospectively reviewed according to the British Thyroid Association 2014 classification. Nodules were divided into Thy 3a (atypical features) and Thy 3f (follicular lesion) categories. Histology was available as a reference for 97 nodules. Pre-surgical evaluations comprised biochemical tests, color-Doppler ultrasonography (US), semi-quantitative elastography-US (USE), contrast-enhanced US (CEUS), and mutation analysis from cytological slides. Thyroid malignancy was the final diagnosis for 19% of surgically-treated nodules...
July 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28670516/generation-of-mouse-spermatogonial-stem-cell-colonies-in-a-non-adherent-culture
#12
Hossein Azizi, Thomas Skutella, Abdolhossein Shahverdi
OBJECTIVE: The properties of self-renewal and division in spermatogonial stem cells (SSCs) support spermatogenesis. There is a number of reported methods for in vitro SSC culture systems. The development of a culture system that effectively supports isolation and selfrenewal of germline stem cells (GSCs) is of tremendous benefit for clinical trials, experimental research, and as potential treatment for male infertility. The current study aims to consider the cultivation and behavior of GSCs in a non-adherent culture system...
July 2017: Cell Journal
https://www.readbyqxmd.com/read/28659894/thyme-oil-reduces-biofilm-formation-and-impairs-virulence-of-xanthomonas-oryzae
#13
Akanksha Singh, Rupali Gupta, Sudeep Tandon, Rakesh Pandey
Xanthomonas oryzae pv. oryzae (Xoo), a common bacterial plant pathogen regulates its virulence and biofilm formation attribute via a chemical method of communication. Disabling this mechanism offers a promising alternative to reduce the virulence and pathogencity of the microorganism. In this study, the effect of thyme (THY) oil on Quorum Sensing mediated synthesis of various virulence factors and biofilm formation was analyzed. Treatment of Xoo with 500 ppm THY oil displayed a significant diminution in swimming, swarming, exopolysaccharide and xanthomonadin secretion...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28659720/the-genetics-of-papillary-microcarcinomas-of-the-thyroid-diagnostic-and-prognostic-implications
#14
REVIEW
Ana Cunha Rodrigues, Gustavo Penna, Elisabete Rodrigues, Patrícia Castro, Manuel Sobrinho-Simões, Paula Soares
Papillary microcarcinoma of the thyroid (mPTC) is defined by the WHO as a papillary thy-roid cancer measuring 10mm or less in diameter and it is nowadays a topic of intense debate among the members of the medical community due to its apparent "epidemic" rise. Although these tumors follow almost always an indolent clinical course and carry an excellent prognosis, it is known that a small sub-set may display a potentially aggressive behavior. Nevertheless, we still lack an accurate way of predict-ing those which will cause significant disease...
June 2017: Current Genomics
https://www.readbyqxmd.com/read/28659445/body-make-thy-own-bispecific-antibody
#15
(no author information available yet)
Synthetic mRNA that's been optimized, modified, and formulated to spur the production of bispecific antibodies in the liver can eradicate large tumors in mice. The strategy circumvents some of the manufacturing challenges associated with conventional antibody production and creates a therapeutic that's easier and more convenient to administer.
June 28, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28654080/studying-cell-cycle-regulated-gene-expression-by-two-complementary-cell-synchronization-protocols
#16
Aintzane Apraiz, Jone Mitxelena, Ana Zubiaga
The gene expression program of the cell cycle represents a critical step for understanding cell cycle-dependent processes and their role in diseases such as cancer. Cell cycle-regulated gene expression analysis depends on cell synchronization into specific phases. Here we describe a method utilizing two complementary synchronization protocols that is commonly used for studying periodic variation of gene expression during the cell cycle. Both procedures are based on transiently blocking the cell cycle in one defined point...
June 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28633498/thymol-as-natural-antioxidant-additive-for-poultry-feed-oxidative-stability-improvement
#17
A Luna, R C Lema-Alba, J S Dambolena, J A Zygadlo, M C Labaque, R H Marin
Antioxidant are regularly included in poultry feed as protection from deterioration during storage. Recently the interest for the use of natural phytochemicals in animal diets has been increased. Thymol (THY) has been proven to be an effective antioxidant for extending broiler meat quality during storage with similar action to the widely used butylated hydroxytoluene (BHT). This study evaluates whether THY can also have a protective effect on the feed mash by assessing its antioxidant potential and related changes in fatty acid (FA) balance...
June 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28585223/a-molecular-tweezer-ameliorates-motor-deficits-in-mice-overexpressing-%C3%AE-synuclein
#18
Franziska Richter, Sudhakar R Subramaniam, Iddo Magen, Patrick Lee, Jane Hayes, Aida Attar, Chunni Zhu, Nicholas R Franich, Nicholas Bove, Krystal De La Rosa, Jacky Kwong, Frank-Gerrit Klärner, Thomas Schrader, Marie-Françoise Chesselet, Gal Bitan
Aberrant accumulation and self-assembly of α-synuclein are tightly linked to several neurodegenerative diseases called synucleinopathies, including idiopathic Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Deposition of fibrillar α-synuclein as insoluble inclusions in affected brain cells is a pathological hallmark of synucleinopathies. However, water-soluble α-synuclein oligomers may be the actual culprits causing neuronal dysfunction and degeneration in synucleinopathies. Accordingly, therapeutic approaches targeting the toxic α-synuclein assemblies are attractive for these incurable disorders...
June 5, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28551987/terbium-iii-luminescent-complexes-as-millisecond-scale-viscosity-probes-for-lifetime-imaging
#19
Anh Thy Bui, Alexei Grichine, Alain Duperray, Pierre Lidon, François Riobé, Chantal Andraud, Olivier Maury
Fluorescent probes that are able to directly measure viscosity are attractive candidates for the study of intracellular environments. We report a new class of luminescent rotors, based on the sensitized emission of a terbium(III) complex. A 4-fold increase in both quantum yield and luminescence lifetime was observed in viscous media for the studied complexes, with a lifetime ranging from 0.23 to 0.89 ms over a broad range of viscosities (0.6-1200 cP). The presented approach, relying on the millisecond-scale luminescence lifetime of the lanthanide ions, was applied to fixed T24 cancer cells using temporal sampling lifetime imaging microscopy...
May 31, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28550098/contralesional-brain-computer-interface-control-of-a-powered-exoskeleton-for-motor-recovery-in-chronic-stroke-survivors
#20
David T Bundy, Lauren Souders, Kelly Baranyai, Laura Leonard, Gerwin Schalk, Robert Coker, Daniel W Moran, Thy Huskey, Eric C Leuthardt
BACKGROUND AND PURPOSE: There are few effective therapies to achieve functional recovery from motor-related disabilities affecting the upper limb after stroke. This feasibility study tested whether a powered exoskeleton driven by a brain-computer interface (BCI), using neural activity from the unaffected cortical hemisphere, could affect motor recovery in chronic hemiparetic stroke survivors. This novel system was designed and configured for a home-based setting to test the feasibility of BCI-driven neurorehabilitation in outpatient environments...
July 2017: Stroke; a Journal of Cerebral Circulation
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