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Steroid dependant asthma

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https://www.readbyqxmd.com/read/27852250/impaired-anti-inflammatory-action-of-glucocorticoid-in-neutrophil-from-patients-with-steroid-resistant-asthma
#1
Meijia Wang, Pengfei Gao, Xiaojie Wu, Yuetao Chen, Yikuan Feng, Qun Yang, Yongjian Xu, Jianping Zhao, Jungang Xie
BACKGROUND: Steroid resistant (SR) asthma is characterized by persistent airway inflammation that fails to resolve despite treatment with high doses of corticosteroids. Furthermore, SR patient airways show increased numbers neutrophils, which are less responsive to glucocorticoid. The present study seeks to determine whether dexamethasone (DEX) has different effect on neutrophils from steroid sensitive (SS) asthmatics compared to SR asthmatics. METHODS: Adults with asthma (n = 38) were classified as SR or SS based on changes in lung FEV1% following a one-month inhaled corticosteroid (ICS) treatment...
November 16, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27815425/stat6-regulates-the-development-of-eosinophilic-versus-neutrophilic-asthma-in-response-to-alternaria-alternata
#2
Andrea C Valladao, Charles W Frevert, Lisa K Koch, Daniel J Campbell, Steven F Ziegler
Human asthma is a heterogeneous disease characterized by the expression of both Th2 and Th17 cytokines. In vitro and in vivo studies have shown a reciprocal regulation between Th2 and Th17 pathways, suggesting a potential induction of neutrophil-promoting Th17 inflammation in the absence of a Th2 response. Alternaria alternata is a clinically relevant allergen that is associated with severe and fatal asthma exacerbations. Exposure to A. alternata is characterized by a predominant Th2 response, but can also induce the production of factors associated with Th17 responses (e...
November 4, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27742828/cytokine-induced-glucocorticoid-resistance-from-eosinophil-activation-protein-phosphatase-5-modulation-of-glucocorticoid-receptor-phosphorylation-and-signaling
#3
Konrad Pazdrak, Christof Straub, Rosario Maroto, Susan Stafford, Wendy I White, William J Calhoun, Alexander Kurosky
The mechanisms contributing to persistent eosinophil activation and poor eosinopenic response to glucocorticoids in severe asthma are poorly defined. We examined the effect of cytokines typically overexpressed in the asthmatic airways on glucocorticoid signaling in in vitro activated eosinophils. An annexin V assay used to measure eosinophil apoptosis showed that cytokine combinations of IL-2 plus IL-4 as well as TNF-α plus IFN-γ, or IL-3, GM-CSF, and IL-5 alone significantly diminished the proapoptotic response to dexamethasone...
November 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27719658/aspirin-intolerance-experimental-models-for-bed-to-bench
#4
Masamichi Yamashita
Aspirin is the oldest non-steroidal anti-inflammatory drug (NSAID), and it sometimes causes asthma-like symptoms known as aspirin-exacerbated respiratory disease (AERD), which can be serious. Unwanted effects of aspirin (aspirin intolerance) are also observed in patients with food-dependent exercise-induced anaphylaxis, a type I allergy disease, and aspirin-induced urticaria (AIU). However the target and the mechanism of the aspirin intolerance are still unknown. There is no animal or cellular model of AERD, because its pathophysiological mechanism is still unknown, but it is thought that inhibition of cyclooxygenase by causative agents lead to an increase of free arachidonic acid, which is metabolized into cysteinyl leukotrienes (cysLTs) that provoke airway smooth muscle constriction and asthma symptoms...
October 5, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27649894/cognitive-behavioural-therapy-cbt-for-adults-and-adolescents-with-asthma
#5
Kayleigh M Kew, Marina Nashed, Valdeep Dulay, Janelle Yorke
BACKGROUND: People with asthma have a higher prevalence of anxiety and depression than the general population. This is associated with poorer asthma control, medication adherence, and health outcomes. Cognitive behavioural therapy (CBT) may be a way to improve the quality of life of people with asthma by addressing associated psychological issues, which may lead to a lower risk of exacerbations and better asthma control. OBJECTIVES: To assess the efficacy of CBT for asthma compared with usual care...
September 21, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27582398/eicosanoid-mediators-in-the-airway-inflammation-of-asthmatic-patients-what-is-new
#6
REVIEW
Marek Sanak
Lipid mediators contribute to inflammation providing both pro-inflammatory signals and terminating the inflammatory process by activation of macrophages. Among the most significant biologically lipid mediators, these are produced by free-radical or enzymatic oxygenation of arachidonic acid named "eicosanoids". There were some novel eicosanoids identified within the last decade, and many of them are measurable in clinical samples by affordable chromatography-mass spectrometry equipment or sensitive immunoassays...
November 2016: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27385593/the-relationship-between-glutathione-s-transferase-p1-and-beta-2-adrenoreceptor-genotypes-with-asthmatic-patients-in-the-turkish-population
#7
Cetin Kaymak, Neslihan Aygun Kocabas, Nesrin Aydın, Derya Oztuna, Ali Esat Karakaya
BACKGROUND: Individual differences in the activity of enzymes that metabolize xenobiotics can impact health and disease. Beta-2 adrenoreceptor (ADRB2) is a functional G-coupled protein expressed in the vascular endothelium of lungs, alveolar walls, and the ganglions of cholinergic nerves which induces bronchodilation in response to catecholamines. Glutathione S-Transferase-P1 (GSTP1) is a candidate pi class GST gene, which controls pi class glutathione S-transferase activity. AIMS: In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma...
September 2016: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/27238165/the-clinical-differences-of-asthma-in-patients-with-molds-allergy
#8
Krzysztof Kołodziejczyk, Andrzej Bożek, Jerzy Jarząb, Radosław Gawlik
INTRODUCTION: Bronchial asthma is an increasing problem worldwide. The course of bronchial asthma is dependent on the type of inducing allergens. The differences between the clinical features of asthma in patients with monovalent allergies to molds and with other allergies were explored. MATERIAL AND METHODS: Randomly selected 1910 patients (924 women and 986 men) between 18-86 years in age were analyzed according to type of allergy and asthma. The diagnosis of asthma was confirmed on the basis of GINA criteria, physical examination and spirometry...
2016: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/27221135/%C3%AE-glucan-exacerbates-allergic-asthma-independent-of-fungal-sensitization-and-promotes-steroid-resistant-th2-th17-responses
#9
Zhonghua Zhang, Jocelyn M Biagini Myers, Eric B Brandt, Patrick H Ryan, Mark Lindsey, Rachael A Mintz-Cole, Tiina Reponen, Stephen J Vesper, Frank Forde, Brandy Ruff, Stacey A Bass, Grace K LeMasters, David I Bernstein, James Lockey, Alison L Budelsky, Gurjit K Khurana Hershey
BACKGROUND: Allergic sensitization to fungi has been associated with asthma severity. As a result, it has been largely assumed that the contribution of fungi to allergic disease is mediated through their potent antigenicity. OBJECTIVE: We sought to determine the mechanism by which fungi affect asthma development and severity. METHODS: We integrated epidemiologic and experimental asthma models to explore the effect of fungal exposure on asthma development and severity...
April 20, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27178888/a-perspective-on-systemic-corticosteroid-therapy-in-severe-bronchial-asthma-in-adults
#10
William B Klaustermeyer, Soo H Choi
BACKGROUND: Systemic corticosteroids have been used in the treatment of asthma since 1950 and are still required for the treatment of acute severe asthma and corticosteroid dependent asthma. OBJECTIVE: To provide an updated overview of clinical considerations of systemic corticosteroids use in severe adult bronchial asthma. METHODS: PubMed searches were undertaken of studies published between 1950 and 2015. RESULTS: In this review the following concepts are discussed...
May 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27000314/omalizumab-therapy-in-a-13-year-old-boy-with-severe-persistent-asthma-and-concomitant-eosinophilic-esophagitis
#11
Stefania Arasi, Stefano Costa, Giuseppe Magazzù, Antonio Ieni, Giuseppe Crisafulli, Lucia Caminiti, Fernanda Chiera, Mario Vaccaro, Michele Miraglia Del Giudice, Giovanni Battista Pajno
BACKGROUND: Eosinophilic esophagitis (EoE) has been defined as "asthma of the esophagus" for the large number of similarities between the two diseases. Omalizumab is an anti-Immunoglobulin E (IgE) antibody currently approved only in allergic IgE-mediated severe persistent uncontrolled asthma and in chronic spontaneous urticaria unresponsive to antihistamines, but it has been tried in other diseases, too. CASE PRESENTATION: We present herein the case of a 13-year-old boy, affected from preschool age by severe chronic allergic asthma poorly controlled despite a generous long-term therapy, and, since he was 8 years old, by eosinophilic esophagitis, responsive to courses of strict elimination diet and semi-elemental diet, even if very burdensome for his quality of life...
2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/26977295/anti-inflammatory-effects-of-the-novel-inhaled-phosphodiesterase-type-4-inhibitor-chf6001-on-virus-inducible-cytokines
#12
Michael R Edwards, Fabrizio Facchinetti, Maurizio Civelli, Gino Villetti, Sebastian L Johnston
Respiratory virus infections precipitate asthma and chronic obstructive pulmonary disease (COPD) exacerbations, with most exacerbations due to rhinovirus infection. Both asthma and COPD exacerbations are not well controlled by steroid therapies, and there is a much research interest in finding improved therapies or combinations of therapies for controlling exacerbations. CHF6001 is a new, inhaled highly potent and selective phosphodiesterase type 4 (PDE4) inhibitor. Using in vitro human bronchial epithelial cells (BEAS-2B), we investigated the potential anti-inflammatory effects of CHF6001 on rhinovirus (RV1B)-induced cytokines...
February 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/26973701/asthma-in-the-elderly-the-effect-of-choline-supplementation
#13
Michele Columbo, Albert S Rohr
BACKGROUND: Asthma in the elderly is poorly understood as very few studies have included these patients. DNA methylation can affect the expression of asthma susceptibility genes. Methyl groups can be produced through a choline dependent pathway. Asthmatics have decreased serum choline. We studied the effect of choline supplementation in elderly asthmatics and associations between different parameters at baseline. METHODS: This is a double-blind, placebo-controlled, cross-over study...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/26958020/guidance-on-the-diagnosis-and-management-of-asthma-among-adults-in-resource-limited-settings
#14
Bruce J Kirenga, Jeremy I Schwartz, Corina de Jong, Thys van der Molen, Martin Okot-Nwang
BACKGROUND: Optimal management of asthma in resource limited settings is hindered by lack of resources, making it difficult for health providers to adhere to international guidelines. The purpose of this review is to identify steps for asthma diagnosis and management in resource limited settings. METHODS: Review of international asthma guidelines and other published studies on diagnosis and management of asthma. RESULTS: We establish that clinical diagnosis of asthma can be made if recurrent respiratory symptoms especially current wheeze or wheeze in the last 12 months are present...
December 2015: African Health Sciences
https://www.readbyqxmd.com/read/26946346/anti-ige-monoclonal-antibody-omalizumab-in-refractory-and-relapsing-eosinophilic-granulomatosis-with-polyangiitis-churg-strauss-data-on-seventeen-patients
#15
Marie Jachiet, Maxime Samson, Vincent Cottin, Jean-Emmanuel Kahn, Guillaume Le Guenno, Philippe Bonniaud, Hervé Devilliers, Laurence Bouillet, Anne Gondouin, Fatma Makhlouf, Nadine Meaux-Ruault, Helder Gil, Boris Bienvenu, André Coste, Matthieu Groh, Violaine Giraud, Stéphane Dominique, Bertrand Godeau, Xavier Puéchal, Chahera Khouatra, Marc Ruivard, Claire Le Jeunne, Luc Mouthon, Loïc Guillevin, Benjamin Terrier
OBJECTIVE: To describe the efficacy and safety of omalizumab, an anti-IgE monoclonal antibody, in patients with refractory and/or relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA). METHODS: We conducted a nationwide retrospective study including EGPA patients who received omalizumab. Response was defined as the absence of asthma and/or sinonasal exacerbations with a prednisone dosage of ≤7.5 mg/day (complete response) or >7.5 mg/day (partial response)...
September 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26889090/wheat-allergy-diagnosis-and-management
#16
REVIEW
Antonella Cianferoni
Triticum aestivum (bread wheat) is the most widely grown crop worldwide. In genetically predisposed individuals, wheat can cause specific immune responses. A food allergy to wheat is characterized by T helper type 2 activation which can result in immunoglobulin E (IgE) and non-IgE mediated reactions. IgE mediated reactions are immediate, are characterized by the presence of wheat-specific IgE antibodies, and can be life-threatening. Non-IgE mediated reactions are characterized by chronic eosinophilic and lymphocytic infiltration of the gastrointestinal tract...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/26855813/eosinophilic-esophagitis-new-insights-in-pathogenesis-and-therapy
#17
REVIEW
Michele Pier Luca Guarino, Michele Cicala, Jose Behar
Eosinophilic esophagitis (EoE) is a clinico-pathological entity with esophageal symptoms and dense esophageal eosinophilic infiltration throughout the esophagus that may persist despite treatment with proton pump inhibitors. This eosinophilic infiltration is usually absent in the stomach, small intestine and colon, although there are a number of reports of patients with a multi-organ involvement. EoE is associated with abnormalities involving TH2-dependent immunity, with multiple environmental factors strongly contributing to disease expression...
February 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26831841/adrenal-suppression-by-inhaled-corticosteroids-in-patients-with-asthma-a-systematic-review-and-quantitative-analysis
#18
Marek L Kowalski, Piotr Wojciechowski, Marta Dziewonska, Przemyslaw Rys
BACKGROUND: Inhaled corticosteroids used for treating persistent asthma can suppress adrenal cortisol secretion. This inhibition of endogenous cortisol secretion is an important marker of systemic steroid activity. Although meta-analyses have demonstrated a dose-dependent suppression of cortisol by inhaled corticosteroids, regardless of inhaler type, the impact of novel freon-free inhaled corticosteroid preparations has not been reviewed. OBJECTIVE: The aim of this study was to synthesize all currently available studies on novel inhaled corticosteroid preparations, including ciclesonide, beclomethasone dipropionate, budesonide, and fluticasone propionate...
January 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/26747278/efficacy-of-omalizumab-xolair%C3%A2-in-patients-with-moderate-to-severe-predominately-chronic-oral-steroid-dependent-asthma-in-taiwan-a-retrospective-population-based-database-cohort-study
#19
Hao-Cheng Chen, Chien-Da Huang, Erin Chang, Han-Pin Kuo
BACKGROUND: Omalizumab (Xolair®), a recombinant monoclonal anti-IgE antibody, has demonstrated efficacy in clinical trials conducted in patients with moderate to severe persistent allergic asthma. We aimed to investigate the efficacy, discontinuation and medical resource utilization of omalizumab in the real-life setting in Taiwan. METHODS: This study was a retrospective, population-based database cohort study using the Taiwan NHIRD from 2007 to 2011 assessing the efficacy of omalizumab therapy over 4 months on changes in asthma medication, asthma control, frequency of exacerbations and hospitalization rates at baseline and after omalizumab discontinuation...
January 8, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/26729801/molecular-mechanisms-of-airway-hyperresponsiveness-in-a-murine-model-of-steroid-resistant-airway-inflammation
#20
Michelle L Manni, Sivanarayana Mandalapu, Kevin J McHugh, M Merle Elloso, Paul L Dudas, John F Alcorn
IL-13 and IL-17A, produced mainly by Th2 and Th17 cells, respectively, have an influential role in asthma pathogenesis. We examined the role of IL-13 and IL-17A in mediating airway hyperresponsiveness (AHR), lung inflammation, and mucus metaplasia in a dual Th2/Th17 model of asthma. IL-13 and/or IL-17A were neutralized using mAbs. Th2/Th17 adoptive transfer induced a mixed asthma phenotype characterized by elevated eosinophilia and neutrophilia, tissue inflammation, mucus metaplasia, and AHR that were partially reversible with steroid treatment...
February 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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