keyword
https://read.qxmd.com/read/38524099/tezepelumab-for-severe-asthma-one-drug-targeting-multiple-disease-pathways-and-patient-types
#21
REVIEW
Reynold Panettieri, Njira Lugogo, Jonathan Corren, Christopher S Ambrose
Asthma is a heterogeneous inflammatory disease of the airways, affecting many children, adolescents, and adults worldwide. Up to 10% of people with asthma have severe disease, associated with a higher risk of hospitalizations, greater healthcare costs, and poorer outcomes. Patients with severe asthma generally require high-dose inhaled corticosteroids and additional controller medications to achieve disease control; however, many patients remain uncontrolled despite this intensive treatment. The treatment of severe uncontrolled asthma has improved with greater understanding of asthma pathways and phenotypes as well as the advent of targeted biologic therapies...
2024: Journal of Asthma and Allergy
https://read.qxmd.com/read/38524073/unremitting-asthma-as-a-presentation-of-pulmonary-nocardiosis-a-case-report
#22
Sandus Khan, Aleksandra Ignatowicz, Nivedha Balaji, Christopher R Chew, Aleksandros Mihilli, Urvesh Patel
Severe, refractory asthma requires a combination of multiple maintenance inhalers and medications including high-dose inhaled corticosteroids and immunomodulators to achieve control of symptoms. The use of inhaled corticosteroids, however, increases the susceptibility of opportunistic bacterial infections, such as Nocardia , resulting in pulmonary nocardiosis. This case describes a 46-year-old patient with a history of severe, refractory asthma who presented with progressively worsening asthma exacerbation symptoms...
February 2024: Curēus
https://read.qxmd.com/read/38522936/-is-inhaled-corticosteroid-step-down-recommended-for-adult-asthma-patients-have-been-well-controlled-over-the-long-term-with-moderate-or-high-dose-inhaled-corticosteroids
#23
JOURNAL ARTICLE
Naoki Okada, Hiroki Kabata, Yoshihito Tanaka, Tetsuya Homma, Sunao Mikura
We conducted a systematic review to examine whether step-down of inhaled corticosteroid (ICS) is recommended for adult patients with asthma have been well controlled with moderate or high-dose inhaled corticosteroids for more than 12 weeks. Seven randomized controlled trials were included. ICS step-down did not increase asthma exacerbations requiring systemic steroid therapy and hospitalization. There was no effect on respiratory function, asthma control, or QOL. No significant differences were observed in serious adverse events or steroid-related adverse events, but the observation period was insufficient to assess long-term effects...
2024: Arerugī, [Allergy]
https://read.qxmd.com/read/38522592/prevalence-and-disparities-in-influenza-vaccination-among-patients-with-copd-a-french-nationwide-population-study
#24
JOURNAL ARTICLE
Maéva Zysman, Anaëlle Coquelin, Nelly Le Guen, Agnès Solomiac, Marina Guecamburu, Marie Erbault, Elodie Blanchard, Nicolas Roche, Sandrine Morin
INTRODUCTION: Despite concordant international recommendations, many surveys found disappointing rates of influenza vaccination in at-risk populations, ranging from 23% in overall COPD population to more than 70% in more severe COPD subjects. Therefore, we assessed the proportion of French COPD patients non-vaccinated for influenza and their clinical and socio-demographic factors. MATERIEL AND METHODS: This was a national retrospective study based on the French health insurance database...
March 22, 2024: Respiratory Medicine
https://read.qxmd.com/read/38520265/real-world-clinical-remission-of-severe-asthma-with-benralizumab-in-spanish-adults-with-severe-asthma
#25
JOURNAL ARTICLE
Eva Martinez-Moragon, Eusebi Chiner, Alexandra Suliana Mogrovejo, Marta Palop Cervera, Inmaculada Lluch Tortajada, Ignacio Boira Enrique, Andrés Fernando Sánchez Vera
Patients with severe eosinophilic asthma experience high risk of exacerbations and reduced quality of life. Benralizumab, a monoclonal antibody binding to IL-5 receptor α subunit, is an approved drug for its treatment. The objective was to describe clinical remission after benralizumab prescription in routine clinical practice. Retrospective multicenter study with data from four hospitals in Valencian Community (Spain) with asthma units between 2019 and 2020. Data was gathered at baseline and after 12 months...
March 23, 2024: Journal of Asthma
https://read.qxmd.com/read/38517856/endoplasmic-reticulum-stress-drives-macrophages-to-produce-il-33-to-favor-th2-polarization-in-the-airways
#26
JOURNAL ARTICLE
Yuan Xiao, Huangping Zhang, Yu Liu, Lihua Mo, Yun Liao, Qinmiao Huang, Liteng Yang, Caijie Zhou, Jiangqi Liu, Xizhuo Sun, Haiqiong Yu, Pingchang Yang
Interleukin (IL)-33 is a key driver of T helper 2 (Th2) cell polarization. Endoplasmic reticulum (ER) stress plays a role in the skewed T cell activation. The objective of this project is to elucidate the role of IL-33 derived from macrophages in inducing Th2 polarization in the airways. In this study, bronchoalveolar lavage fluids (BALF) were collected from patients with asthma and healthy control subjects. Macrophages were isolated from the BALF by flow cytometry cell sorting. An asthmatic mouse model was established using the ovalbumin/alum protocol...
March 22, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38516875/evaluation-of-patients-satisfaction-with-domiciliary-biological-treatment-in-severe-asthma-a-portuguese-survey
#27
JOURNAL ARTICLE
Joana Lourenço, Ana Paula Vaz, Rosa Anita Fernandes, Cristina Lopes, Ana Luísa Fernandes
Dear Editor, According to GINA, severe asthma is defined as uncontrolled asthma, despite therapy adherence with an optimized high dose of inhaled corticosteroid plus long-acting ß2-agonist coupled with management of modifiable factors/comorbidities, that worsens when this treatment is decreased. It affects a significant portion of asthmatic patients and imposes a high risk of exacerbations and mortality, which are associated with significant healthcare costs and psychosocial impact...
March 20, 2024: Monaldi Archives for Chest Disease
https://read.qxmd.com/read/38515071/long-term-multicenter-comparison-shows-equivalent-efficacy-of-monoclonal-antibodies-in-severe-asthma-therapy
#28
JOURNAL ARTICLE
Moritz Z Kayser, Hendrik Suhling, Jan Fuge, Christopher A Hinze, Nora Drick, Nikolaus Kneidinger, Jürgen Behr, Christian Taube, Tobias Welte, Ina Haasler, Katrin Milger
BACKGROUND: Monoclonal antibodies (biologics) drastically changed severe asthma therapy. Mepolizumab (anti-interleukin (IL) 5), benralizumab (anti-IL5 receptor alpha), and dupilumab (anti-IL4/13) are the most used biologics in this context. While all biologics are efficient individually, the choice of biologic is complicated by insufficient data on their comparative long-term treatment efficacy. Here, we compare the real-life efficacy of these biologics in asthma therapy over 12 months...
March 21, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38514095/th2-skewed-peripheral-t-helper-cells-drives-b-cells-in-allergic-bronchopulmonary-aspergillosis
#29
JOURNAL ARTICLE
Rong-Guang Luo, Yi-Fan Wu, Hai-Wen Lu, Dong Weng, Jia-Yan Xu, Le-Le Wang, Li-Sha Zhang, Cai-Qi Zhao, Jian-Xiong Li, Yong Yu, Xin-Ming Jia, Jin-Fu Xu
INTRODUCTION: Patients with allergic bronchopulmonary aspergillosis (ABPA) suffer from repeated exacerbations. However, the involvement of T cell subsets remains unclear. METHODS: We enrolled ABPA patients, asthma patients and healthy controls. Th1, Th2, Th17, Treg and IL-21+ CD4+ T cells in total or sorted subsets of peripheral blood mononuclear cells (PBMCs) and ABPA Bronchoalveolar Lavage fluid (BALF) were analyzed by flow cytometry. RNA sequencing of subsets of CD4+ T cells were done in exacerbated ABPA patients and healthy controls...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38514093/gasdermin-b-an-asthma-susceptibility-gene-promotes-mavs-tbk1-signaling-and-airway-inflammation
#30
JOURNAL ARTICLE
Tao Liu, Siqi Liu, Xianliang Rui, Ye Cao, Julian Hecker, Feng Guo, Yihan Zhang, Lu Gong, Yihan Zhou, Yuzhen Yu, Nandini Krishnamoorthyni, Samuel Bates, Sung Chun, Nathan Boyer, Shuang Xu, Jin-Ah Park, Mark A Perrella, Bruce D Levy, Scott T Weiss, Hongmei Mou, Benjamin A Raby, Xiaobo Zhou
RATIONALE: Respiratory virus-induced inflammation is the leading cause of asthma exacerbation, frequently accompanied by induction of IFN-stimulated genes (ISGs). How asthma genetic susceptible genes modulate cellular response upon viral infection through fine-tuning ISGs induction and subsequent airway inflammation in genetically susceptible asthmatics remains largely unknown. OBJECTIVES: To decipher the functions of GSDMB in respiratory virus-induced lung inflammation...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38510797/dysfunctional-neutrophil-type-1-interferon-responses-in-preschool-children-with-recurrent-wheezing-and-il-4-mediated-aeroallergen-sensitization
#31
JOURNAL ARTICLE
Anne M Fitzpatrick, Min Huang, Ahmad F Mohammad, Susan T Stephenson, Rishikesan Kamaleswaran, Jocelyn R Grunwell
BACKGROUND: The innate mechanisms associated with viral exacerbations in preschool children with recurrent wheezing are not understood. OBJECTIVE: We sought to assess differential gene expression in blood neutrophils from preschool children with recurrent wheezing, stratified by aeroallergen sensitization, at baseline and after exposure to polyinosinic:polycytidylic acid (poly(I:C)) and also to examine whether poly(I:C)-stimulated blood neutrophils influenced airway epithelial gene expression...
May 2024: J Allergy Clin Immunol Glob
https://read.qxmd.com/read/38508336/gaps-in-care-among-uncontrolled-severe-asthma-patients-in-the-united-states
#32
JOURNAL ARTICLE
Tara Carr, Joseph Tkacz, Yen Chung, Christopher S Ambrose, Joseph Spahn, Pallavi Rane, Yan Wang, Andrew W Lindsley, Benjamin Lewing, Autumn Burnette
BACKGROUND: Understanding the implementation of key guideline recommendations is critical for management of severe asthma (SA) in the treatment of uncontrolled disease. OBJECTIVE: To assess specialist visits and medication escalation in US patients with SA following events indicating-uncontrolled-disease (EUD) and associations with health outcomes and social disparity indicators. METHODS: SA patients appearing in administrative claims data spanning 2015-2020 were indexed hierarchically on asthma-related EUD, including hospitalizations, emergency department visits with systemic corticosteroid treatment (SCS), or outpatient visits with SCS...
March 18, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38507442/a-case-of-bullous-pemphigoid-following-administration-of-anti-il-31-receptor-a-antibody
#33
JOURNAL ARTICLE
Ryosuke Masuyuki, Emi Sato, Shinichi Imafuku
Bullous pemphigoid (BP), an autoimmune bullous dermatosis, occurs predominantly in older individuals. Nemolizumab, a humanized monoclonal antibody against the interleukin (IL)-31 receptor A, is used to treat severe atopic dermatitis (AD) in Japan. However, it can cause several adverse events, such as exacerbation of AD, erythema, and eosinophilia. Herein, we describe a case of prurigo-type AD developing BP after nemolizumab administration. A 62-year-old man with prurigo-type AD and asthma presented with serious, refractory itching...
March 20, 2024: Journal of Dermatology
https://read.qxmd.com/read/38505397/primary-care-asthma-attack-prediction-models-for-adults-a-systematic-review-of-reported-methodologies-and-outcomes
#34
REVIEW
Lijun Ma, Holly Tibble
Prognostic models hold great potential for predicting asthma exacerbations, providing opportunities for early intervention, and are a popular area of current research. However, it is unclear how models should be compared and contrasted, given their differences in both design and performance, particularly with a view to potential implementation in routine practice. This systematic review aimed to identify novel predictive models of asthma attacks in adults and compare differences in construction related to populations, outcome definitions, prediction time horizons, algorithms, validation, and performance estimation...
2024: Journal of Asthma and Allergy
https://read.qxmd.com/read/38503436/investigating-the-air-quality-surrounding-new-schools-in-england-polluted-playgrounds-and-school-buildings-are-a-source-of-avoidable-harm
#35
JOURNAL ARTICLE
Yasmin Mahfouz, Florence Tydeman, Meredith Robertson
OBJECTIVE: To assess levels of pollutants at the sites of new schools and whether pupils are likely to be protected from associated risks. SETTING: Air pollution causes damage to children's health by increasing respiratory tract infection rates, asthma exacerbations, allergies and childhood cancers. Further effects include poorer neurocognitive outcomes and multisystemic illness in adulthood. DESIGN: We obtained a list of all 187 proposed new schools in England from 2017 to 2025 and found locations for 147 of them...
March 19, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38503107/medium-term-exposure-to-size-fractioned-particulate-matter-and-asthma-exacerbations-in-china-a-longitudinal-study-of-asthmatics-with-poor-medication-adherence
#36
JOURNAL ARTICLE
Yufan Feng, Wenyi Zhang, Jing Wei, Dingyuan Jiang, Shilu Tong, Cunrui Huang, Zhiwei Xu, Xiling Wang, Junwen Tao, Zhiwei Li, Jihong Hu, Yongming Zhang, Jian Cheng
BACKGROUND: Studies have shown that short- and long-term exposure to particulate matter (PM) can increase the risk of asthma morbidity and mortality. However, the effect of medium-term exposure remains unknown. We aim to examine the effect of medium-term exposure to size-fractioned PM on asthma exacerbations among asthmatics with poor medication adherence. METHODS: We conducted a longitudinal study in China based on the National Mobile Asthma Management System Project that specifically and routinely followed asthma exacerbations in asthmatics with poor medication adherence from April 2017 to May 2019...
March 18, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38500798/use-of-compex-in-eosinophilic-patients-with-severe-uncontrolled-asthma-on-benralizumab
#37
JOURNAL ARTICLE
Clare Bolton, Tim Harrison, Njira Lugogo, Anne Fuhlbrigge, Ian Hirsch, Thomas Bengtsson, Stefan Peterson, Martin Sidaway, Esther Garcia Gil, Malin Fagerås, Carla A Da Silva
BACKGROUND: CompEx Asthma, a composite end-point for asthma exacerbations, captures clinically relevant, diary-based acute worsening events (AWEs) (defined as deterioration in daily peak expiratory flow concurrent with deterioration in asthma symptoms and/or rescue therapy use) and severe exacerbations (SevEx) (defined by American Thoracic Society/European Respiratory Society guidelines). We hypothesised that CompEx and SevEx would show similar benralizumab treatment effects and correlations to blood eosinophil counts in patients with severe asthma...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38499294/general-practitioners-perspectives-on-diagnostic-tests-for-children-a-qualitative-interview-study
#38
JOURNAL ARTICLE
Elizabeth T Thomas, Margaret Glogowska, Gail Hayward, Peter Gill, Rafael Perera, Carl Heneghan
Background Most healthcare contacts for children in the UK occur in general practice. Diagnostic tests can be beneficial in narrowing differential diagnoses, however, there is substantial variation in the use of tests for children in general practice. Unwarranted variation in testing can lead to variation in quality of care and exacerbate health inequities. No prior study has tried to understand why variation in testing exists for children in general practice. Aim To explore GP perspectives on using diagnostic tests for children in primary care and the underlying drivers of variation...
March 18, 2024: British Journal of General Practice
https://read.qxmd.com/read/38499061/activated-non-neuronal-cholinergic-system-correlates-with-non-type-2-inflammation-and-exacerbations-in-severe-asthma
#39
JOURNAL ARTICLE
Dan Huang, Li Zhang, Ying Liu, Ji Wang, Jie Zhang, Katherine J Baines, Gang Liu, Alan Chen-Yu Hsu, Fang Wang, Zhihong Chen, Brian G Oliver, Min Xie, Ling Qin, Dan Liu, Huajing Wan, Fengming Luo, Weimin Li, Gang Wang, Peter G Gibson
BACKGROUND: Non-neuronal cholinergic system (NNCS) contributes to various inflammatory airway diseases. However, the role of NNCS in severe asthma (SA) remains largely unexplored. OBJECTIVE: To explore airway NNCS in SA. METHODS: In this prospective cohort study based on the Australasian Severe Asthma Network in a real-world setting, patients with SA (n=52) and non-SA (n=104) underwent clinical assessment and sputum induction. The mRNA levels of NNCS components and proinflammatory cytokines in sputum were detected using RT-qPCR, and the concentrations of acetylcholine (Ach)-related metabolites were examined using LC-MS/MS...
March 16, 2024: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/38497844/a-survey-study-on-antibiotic-prescription-practices-for-acute-asthma-exacerbations-an-european-academy-of-allergy-and-clinical-immunology-task-force-report
#40
JOURNAL ARTICLE
Anne-Lotte Redel, Wojciech Feleszko, Alessandra Arcolaci, Francesca Cefaloni, Marina Atanaskovic-Markovic, Gert-Jan Braunstahl, Cristina Boccabella, Matteo Bonini, Aspasia Karavelia, Eefje Louwers, Norbert Mülleneisen, Liam O'Mahony, Laura Pini, Anna Rapiejko, Esmeralda Shehu, Milena Sokolowska, Eva Untersmayr, Gerdien Tramper-Stranders
INTRODUCTION: Guidelines recommend treating asthma exacerbations (AAEs) with bronchodilators combined with inhaled and/or systemic corticosteroids. Indications for antibiotic prescriptions for AAEs are usually not incorporated although the literature shows antibiotics are frequently prescribed. AIM: To investigate the antibiotic prescription rates in AAEs and explore the possible determining factors of those practices. METHODS: A digital survey was created to determine the antibiotic prescription rates in AAEs and the influencing factors for the prescription practices...
March 2024: Clinical and Translational Allergy
keyword
keyword
23347
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.