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Asthma exacerbation

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https://www.readbyqxmd.com/read/29454163/exacerbations-in-adults-with-asthma-a-systematic-review-and-external-validation-of-prediction-models
#1
Rik Jb Loymans, Thomas Pa Debray, Persijn J Honkoop, Evelien H Termeer, Jiska B Snoeck-Stroband, Tjard Rj Schermer, Willem Jj Assendelft, Merel Timp, Kian Fan Chung, Ana R Sousa, Jaap K Sont, Peter J Sterk, Helen K Reddel, Gerben Ter Riet
BACKGROUND: Several prediction models assessing future risk of exacerbations in adult patients with asthma have been published. Applicability of these models is uncertain because their predictive performance has often not been assessed beyond the population in which they were derived. OBJECTIVE: This study aimed to identify and critically appraise prediction models for asthma exacerbations and validate them in two clinically distinct populations. METHODS: PubMed and EMBASE were searched to April 2017 for reports describing adult asthma populations in which multivariable models were constructed to predict exacerbations during any time frame...
February 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29454162/anxiety-depression-and-asthma-control-changes-after-standardized-treatment
#2
Joaquin Sastre, Astrid Crespo, Toni Fernandez-Sanchez, Manuel Rial, Vicente Plaza
BACKGROUND: It has been documented that anxiety and depression are prevalent in patients with asthma and are associated with greater frequency of exacerbations, increased use of health-care resources, and poor asthma control. OBJECTIVES: Our study examined not only the association of asthma diagnosis with symptoms of depression/anxiety and asthma control at baseline, but also over a 6-month period of specialist supervision. METHODS: We enrolled 3,182 patients with moderate-severe asthma...
February 14, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29452277/association-between-obesity-and-acute-severity-among-patients-hospitalized-for-asthma-exacerbation
#3
Sarah Kyuragi Luthe, Atsushi Hirayama, Tadahiro Goto, Mohammad Kamal Faridi, Carlos A Camargo, Kohei Hasegawa
BACKGROUND: Although studies have demonstrated relations between obesity and incident asthma, little is known about the association of obesity with acute severity in adults hospitalized for asthma exacerbation. OBJECTIVES: To investigate the association of obesity with acute severity of asthma exacerbation. METHODS: This is a retrospective cohort study using population-based data of 8 geographically diverse US states from 2010 through 2013...
February 13, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29452202/effectiveness-of-indoor-allergen-reduction-in-the-management-of-asthma-a-systematic-review
#4
Brian F Leas, Kristen E D'Anci, Andrea J Apter, Tyra Bryant-Stephens, Marcus P Lynch, Janice L Kaczmarek, Craig A Umscheid
BACKGROUND: This review will inform updated National Asthma Education and Prevention Program clinical practice guidelines. OBJECTIVE: To evaluate the effectiveness of allergen reduction interventions on asthma outcomes. METHODS: We systematically searched the gray literature and five bibliographic databases. Eligible studies included systematic reviews, randomized controlled trials, and nonrandomized interventional studies. Risk of bias was assessed using the Cochrane Risk of Bias instrument and the Newcastle-Ottawa scale...
February 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29451705/modeling-asthma-pitfalls-promises-and-the-road-ahead
#5
REVIEW
Helene F Rosenberg, Kirk M Druey
Asthma is a chronic, heterogeneous, and recurring inflammatory disease of the lower airways, with exacerbations that feature airway inflammation and bronchial hyperresponsiveness. Asthma has been modeled extensively via disease induction in both wild-type and genetically manipulated laboratory mice (Mus musculus). Antigen sensitization and challenge strategies have reproduced numerous important features of airway inflammation characteristic of human asthma, notably the critical roles of type 2 T helper cell cytokines...
February 16, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29450204/ppars-key-regulators-of-airway-inflammation-and-potential-therapeutic-targets-in-asthma
#6
Asoka Banno, Aravind T Reddy, Sowmya P Lakshmi, Raju C Reddy
Asthma affects approximately 300 million people worldwide, significantly impacting quality of life and healthcare costs. While current therapies are effective in controlling many patients' symptoms, a large number continue to experience exacerbations or treatment-related adverse effects. Alternative therapies are thus urgently needed. Accumulating evidence has shown that the peroxisome proliferator-activated receptor (PPAR) family of nuclear hormone receptors, comprising PPARα, PPARβ/δ, and PPARγ, is involved in asthma pathogenesis and that ligand-induced activation of these receptors suppresses asthma pathology...
2018: Nuclear Receptor Research
https://www.readbyqxmd.com/read/29448086/exposure-to-diisodecyl-phthalate-exacerbated-th2-and-th17-mediated-asthma-through-aggravating-oxidative-stress-and-the-activation-of-p38-mapk
#7
Wei Qin, Ting Deng, Haiyan Cui, Qian Zhang, Xudong Liu, Xu Yang, Mingqing Chen
Diisodecyl phthalate (DIDP) is considered to be one of the less toxic phthalates. However epidemiological studies suggest that DIDP is associated with the occurrence of asthma. The effect of DIDP exposure on allergic asthma and the underlying mechanism have not been fully elucidated. Here, mice were exposed to DIDP and sensitization with OVA. The results demonstrated that DIDP exposure aggravated allergic asthma. Exposure to 15 mg/kg/day DIDP markedly exacerbated airway remodeling and promoted airway hyperresponsiveness (AhR)...
February 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29447223/virome-and-bacteriome-characterization-of-children-with-pneumonia-and-asthma-in-mexico-city-during-winter-seasons-2014-and-2015
#8
Jose A Romero-Espinoza, Yazmin Moreno-Valencia, Rodrigo H Coronel-Tellez, Manuel Castillejos-Lopez, Andres Hernandez, Aaron Dominguez, Angel Miliar-Garcia, Arturo Barbachano-Guerrero, Rogelio Perez-Padilla, Alejandro Alejandre-Garcia, Joel A Vazquez-Perez
BACKGROUND: Acute asthma exacerbations and pneumonia are important causes of morbidity and mortality in children and may coexist in the same children, although symptom overlap may lead to difficulties in diagnosis. Microbial and viral diversity and differential abundance of either may play an important role in infection susceptibility and the development of acute and chronic respiratory diseases. OBJECTIVES: To describe the virome and bacteriome present in the upper respiratory tract of hospitalized children with a clinical diagnosis of asthma and pneumonia during an acute exacerbation and an acute respiratory illness ARI episode respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29445779/wireless-sensor-dependent-ecological-momentary-assessment-for-pediatric-asthma-mhealth-applications
#9
Chris M Buonocore, Rosemary A Rocchio, Alfonso Roman, Christine E King, Majid Sarrafzadeh
Pediatric asthma is a prevalent chronic disease condition that can benefit from wireless health systems through constant symptom management. In this paper, we propose a smart watch based wireless health system that incorporates wireless sensing and ecological momentary assessment (EMA) to determine an individual's asthma symptoms. Since asthma is a multifaceted disease, this approach provides individualized symptom assessments through various physiological and environmental wireless sensor based EMA triggers specific to common asthma exacerbations...
July 2017: ...IEEE...International Conference on Connected Health: Applications, Systems and Engineering Technologies
https://www.readbyqxmd.com/read/29445292/late-onset-asthma-current-perspectives
#10
REVIEW
Tsunahiko Hirano, Kazuto Matsunaga
Because the pathophysiology of asthma has diverse characteristics, to manage the disease effectively, it is important for clinicians to distinguish among the clinical phenotypes. Among them, adult-onset asthma, that is, late-onset asthma (LOA), is increasing because of the aging of the population. The phenotype of LOA is largely divided into two types according to the presence or absence of eosinophilic inflammation, T-helper (Th)2- and non-Th2-associated LOA. Especially in Th2 LOA related to rhinosinusitis, as pulmonary function at onset is poor and asthma exacerbations occur frequently, it is important to detect this phenotype in the early phase by using a biomarker of Th2-type inflammation such as fractional exhaled nitric oxide (FE NO )...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29441464/the-toxicology-of-engineered-nanomaterials-in-asthma
#11
REVIEW
Mark D Ihrie, James C Bonner
PURPOSE OF REVIEW: The explosive growth of the nanotechnology industry has necessitated the examination of engineered nanomaterials (ENMs) for their toxicity. The unique properties that make ENMs useful also make them a health risk, and individuals with pre-existing diseases such as asthma are likely more susceptible. This review summarizes the current literature on the ability of ENMs to both exacerbate and directly cause asthma. RECENT FINDINGS: Recent studies highlight the ability of metal nanoparticles (NPs) and carbon nanotubes (CNTs) to not only exacerbate pre-existing asthma in animal models but also initiate allergic airway disease directly...
February 13, 2018: Current Environmental Health Reports
https://www.readbyqxmd.com/read/29438772/lumen-area-change-delta-lumen-between-inspiratory-and-expiratory-ct-as-a-measure-of-severe-outcomes-in-asthma
#12
Sung Shine Shim, Mark L Schiebler, Michael D Evans, Nizar Jarjour, Ron L Sorkness, Loren Denlinger, Alfonso Rodriguez, Sally Wenzel, Eric A Hoffman, Ching-Long Lin, David S Gierada, Mario Castro, Sean B Fain
BACKGROUND: Quantitative computed tomography (QCT) biomarkers of airway morphology hold potential for understanding and monitoring regional airway remodeling in asthma. OBJECTIVE: We sought to determine if the change of airway lumen area between TLC and FRC lung volumes measured from CT imaging data was correlated with severe outcomes in asthma patients. METHODS: We studied 152 asthma patients (90 female and 62 male) and 33 normal subjects (12 female and 21 male) with QCT...
February 10, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29437489/controller-adherence-following-hospital-discharge-in-high-risk-children-a-pilot-randomized-trial-of-text-message-reminders
#13
Chén C Kenyon, Siobhan M Gruschow, William O Quarshie, Heather Griffis, Michelle C Leach, Joseph J Zorc, Tyra C Bryant-Stephens, Victoria A Miller, Chris Feudtner
OBJECTIVE: To assess the feasibility of a mobile health, inhaled corticosteroid (ICS) adherence reminder intervention and to characterize adherence trajectories immediately following severe asthma exacerbation in high-risk urban children with persistent asthma. METHODS: Children aged 2-13 with persistent asthma were enrolled in this pilot randomized controlled trial during an asthma emergency department (ED) visit or hospitalization. Intervention arm participants received daily text message reminders for 30 days, and both arms received electronic sensors to measure ICS use...
February 13, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29437221/the-complexity-of-determining-whether-a-nursing-home-transfer-is-avoidable-at-time-of-transfer
#14
Kathleen T Unroe, Jennifer L Carnahan, Susan E Hickman, Greg A Sachs, Zachary Hass, Greg Arling
OBJECTIVES: To describe the relationship between nursing facility resident risk conditions and signs and symptoms at time of acute transfer and diagnosis of conditions associated with potentially avoidable acute transfers (pneumonia, urinary tract infection, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) or asthma, dehydration, pressure sores). DESIGN: As part of a demonstration project to reduce potentially avoidable hospital transfers, Optimizing Patient Transfers, Impacting Medical Quality, Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) project clinical staff collected data on residents who transferred to the emergency department (ED) or hospital...
February 13, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29437007/blood-eosinophils-as-biomarkers-to-drive-treatment-choices-in-asthma-and-copd
#15
Francesco Patalano, Konstantinos Kostikas, Caterina Brindicci
Both asthma and COPD are complex, heterogeneous conditions comprising a wide range of phenotypes, some of which are refractory to currently available treatments. Elucidation of these phenotypes and identification of biomarkers with which to recognize them and guide appropriate treatment remains a priority. This review describes the utility of blood eosinophils as a surrogate biomarker of eosinophilic airway inflammation, a common feature of specific asthma and COPD phenotypes. The role of blood eosinophils in airway disease is described, as is their relevance in reflecting airway eosinophilia...
February 12, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29432960/use-of-ics-laba-combinations-or-lama-is-associated-with-a-lower-risk-of-acute-exacerbation-in-patients-with-coexistent-copd-and-asthma
#16
Vincent Yi-Fong Su, Kuang-Yao Yang, Yao-Hsu Yang, Ying-Huang Tsai, Diahn-Warng Perng, Wei-Juin Su, Kun-Ta Chou, Kang-Cheng Su, Yung-Feng Yen, Pau-Chung Chen
BACKGROUND: Based on current guidelines, more research is urgently needed to guide appropriate treatment for patients with asthma-chronic obstructive pulmonary disease overlap. OBJECTIVE: The objective of this study was to investigate medication effects on acute exacerbation in patients with coexistent COPD and asthma. METHODS: Using Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study to evaluate medication effects in patients with COPD and asthma...
February 9, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29432042/relationship-between-upper-airway-diseases-exhaled-nitric-oxide-and-bronchial-hyperresponsiveness-to-methacholine
#17
Marina Lluncor, Pilar Barranco, Emerson-Daniel Amaya, Javier Domínguez-Ortega, Valentín López-Carrasco, Isabel Coman, Santiago Quirce
OBJECTIVE: The "united airway disease" concept is based on the bidirectional interaction between asthma and rhinitis. The aim of this study was to determine the relationship between upper airway diseases and bronchial hyperresponsiveness (BHR), as well as their association with the fractional concentration of exhaled nitric oxide (FeNO) and atopy in patients with persistent symptoms suggestive of asthma requiring methacholine challenge testing (MCT) to confirm asthma diagnosis. METHODS: A cross-sectional prospective study was carried out in adult patients with persistent asthma-like symptoms and negative bronchodilator testing...
February 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29431885/important-and-specific-role-for-basophils-in-acute-allergic-reactions
#18
Peter Korošec, Bernhard F Gibbs, Matija Rijavec PhD, Adnan Custovic, Paul J Turner
IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FcεRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response...
February 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29431176/phd-forum-multimodal-iot-and-emr-based-smart-health-application-for-asthma-management-in-children
#19
Utkarshani Jaimini
According to a study done in 2014 by National Health Interview Survey around 6.3 million children in United States suffer from asthma [1]. Asthma remains one of the leading reasons for pediatric admissions to children's hospitals, and has a prevalence rate of approximately 10% in children and it leads to missed days from school and other societal costs. This occurs despite improved medications to control asthma symptoms. Asthma management is challenging as it involves understanding asthma causes and avoiding asthma triggers that are both multi-factorial and individualistic in nature...
May 2017: Proc Int Conf Smart Comput SMARTCOMP
https://www.readbyqxmd.com/read/29428092/detection-of-specific-bacterial-agents-by-quantitative-pcr-assays-in-the-bronchoalveolar-lavage-fluid-of-dogs-with-eosinophilic-bronchopneumopathy-vs-dogs-with-chronic-bronchitis-and-healthy-dogs
#20
A M Canonne, I Peters, E Roels, L Desquilbet, C Clercx
In humans, Mycoplasma pneumoniae and Bordetella pertussis infections are suggested to trigger or exacerbate asthma. Whether Mycoplasma or Bordetella are associated with chronic inflammatory bronchial diseases in dogs has not been investigated. The aim of this study was to assess detection rates of Mycoplasma canis (M. canis), M. cynos and Bordetella bronchiseptica (Bb), in dogs with eosinophilic bronchopneumopathy (EBP) and chronic bronchitis (CB), compared with healthy dogs. Specific quantitative PCR (qPCR) analysis for M...
February 2018: Veterinary Journal
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