keyword
MENU ▼
Read by QxMD icon Read
search

Asthma exacerbation

keyword
https://www.readbyqxmd.com/read/29228279/in-vitro-model-of-fully-differentiated-human-nasal-epithelial-cells-infected-with-rhinovirus-reveals-epithelium-initiated-immune-responses
#1
Kai Sen Tan, Hsiao Hui Ong, Yan Yan, Jing Liu, Chunwei Li, Yew Kwang Ong, Kim Thye Thong, Hyung Won Choi, De-Yun Wang, Vincent T Chow
Human rhinoviruses (HRVs) are the commonest cause of the common cold. While less pathogenic compared to other respiratory viruses, it is frequently associated with exacerbation of chronic respiratory diseases such as rhinosinusitis and asthma exacerbation. Currently, there are limited studies on HRV infection of nasal epithelial cells despite being the first site of viral contact, immune initiation, and airway inter-connectivity. Hence, we established a model of HRV infection of in vitro differentiated human nasal epithelial cells (hNECs) derived from multiple individuals...
December 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29227587/corticosteroid-faceoff-which-is-best-for-treating-asthma-and-copd-exacerbations
#2
William Heuser, Richard Menaik, Sanjey Gupta, Robert Rucco
No abstract text is available yet for this article.
May 2017: JEMS: a Journal of Emergency Medical Services
https://www.readbyqxmd.com/read/29221581/biomarkers-for-severe-eosinophilic-asthma
#3
REVIEW
Steven W Yancey, Oliver N Keene, Frank C Albers, Hector Ortega, Stewart Bates, Eugene R Bleecker, Ian Pavord
The last decade has seen the approval of several new biologics for the treatment of severe asthma-targeting specific endotypes and phenotypes. This review will examine how evidence generated from the mepolizumab clinical development program showed that blood eosinophil counts, rather than sputum or tissue eosinophil counts, evolved as a pharmacodynamic and predictive biomarker for the efficacy of treatment with mepolizumab in patients with severe eosinophilic asthma. Based on the available evidence and combined with clinical judgement, a baseline blood eosinophil threshold of 150 cells/μL or greater or a historical blood eosinophil threshold of 300 cells/μL or greater will allow selection of patients with severe eosinophilic asthma who are most likely to achieve clinically significant reductions in the rate of exacerbations with mepolizumab treatment...
December 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29221328/uncontrolled-and-under-diagnosed-asthma-in-a-damascus-shelter-during-the-syrian-crisis
#4
Yousser Mohammad, Shaaban Rafea, Youssef Latifeh, Ali Khaddam, Bisher Sawaf, Mhd Ismael Zakaria, Mohammad Sadek Al Masalmeh, Yaser Fawaz, Abdoulraouf Allaham, Imad Almani, Hiba El-Tarcheh, Ayham Ghazal, Ali Zaher, Hala Rifai, Hamed Joumah, S Dresden Glockler-Lauf, Teresa To
Background: Studies have shown that poor shelter or dwelling conditions may lead to deteriorations in health. Those with asthma may be more susceptible to compromised living conditions and stress leading to a higher risk of asthma exacerbations. To describe the asthma control and quality of life of individuals with diagnosed asthma living in a shelter in Damascus, Syria and estimate the prevalence of respiratory symptoms in shelter dwellers without diagnosed asthma. Methods: In this cross-sectional study, all individuals 5 years and older living in Al-Herjalleh shelter with diagnosed asthma were recruited to complete a questionnaire, which included items related to their respiratory symptoms, asthma exacerbations, exposure to asthma triggers, medication use, and health-related quality of life before and since entering the shelter...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29217600/asthma-phenotypes-do-cough-and-wheeze-predict-exacerbations-in-persistent-asthma
#5
Jaymin B Morjaria, Alan S Rigby, Alyn H Morice
Little is known of the long-term symptom profile in uncontrolled asthma and whether symptoms can predict distinct phenotypes. The primary objective of these analyses was to assess diurnal profile of cough and wheeze in an uncontrolled asthma population. Secondary outcomes were to examine how these symptom profiles influence response to treatment.Twice-daily electronically recorded data from 1701 patients were examined in relation to the population demographics. Reliever treatment with salbutamol was then compared with extra-fine beclometasone/formoterol maintenance and reliever therapy (MART)...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29215378/developing-resident-sensitive-quality-measures-a-model-from-pediatric-emergency-medicine
#6
Daniel J Schumacher, Eric S Holmboe, Cees van der Vleuten, Jamiu O Busari, Carol Carraccio
PURPOSE: To begin closing the gap with respect to quality measures available for use among residents, the authors sought to identify and develop resident-sensitive quality measures (RSQMs) for use in the pediatric emergency department (PED) setting. METHOD: In May 2016, the authors reviewed National Quality Measures Clearinghouse (NQMC) measures to identify resident-sensitive measures. To create additional measures focused on common, acute illnesses (acute asthma exacerbation, bronchiolitis, closed head injury [CHI]) in the PED, the authors used a nominal group technique (NGT) and Delphi process from September to December 2016...
December 5, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29213221/omalizumab-in-children-with-severe-allergic-asthma-the-italian-real-life-experience
#7
Amelia Licari, Riccardo Castagnoli, Chiara Denicolò, Linda Rossini, Manuela Seminara, Lucia Sacchi, Giorgia Testa, Mara De Amici, Gian Luigi Marseglia
Background: Anti-IgE treatment represents a major breakthrough in the therapeutic management of severe allergic asthma. To date, omalizumab is the only biological drug currently licensed as add-on therapy in children aged > 6 years with moderate-to-severe and severe allergic asthma uncontrolled after treatment with high dose of inhaled corticosteroids plus long-acting inhaled beta2-agonist. The clinical efficacy and safety of omalizumab treatment in the pediatric population has been extensively documented in specific trials and consistently expanded from real-life studies...
March 2017: Current Respiratory Medicine Reviews
https://www.readbyqxmd.com/read/29211599/quantitation-of-salbutamol-using-micro-volume-blood-sampling-applications-to-exacerbations-of-pediatric-asthma
#8
Rebecca L Cordell, Thalassa S E Valkenburg, Hitesh C Pandya, Daniel B Hawcutt, Malcolm G Semple, Paul S Monks
OBJECTIVES: A novel gas chromatography-mass spectrometry (GC-MS) method has been developed to quantify salbutamol in micro-volumes (10 µL) of blood. A potential application is paediatric therapeutic dose monitoring (TDM) in acute severe asthma. METHODS: At presentation, the children receive multiple doses of salbutamol (inhaled, nebulised and occasionally intravenous) but it is difficult to distinguish children who do not respond to treatment because of inadequate concentrations from those with toxicity, as symptoms are similar...
December 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29211545/efficacy-and-safety-of-benralizumab-for-eosinophilic-asthma-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Bao-Ping Tian, Gen-Sheng Zhang, Jian Lou, Hong-Bin Zhou, Wei Cui
CONTEXT: Benralizumab is a humanized monoclonal antibody that targets the α chain of the IL-5 receptor (IL-5Rα) and is currently being assessed in clinical trials for asthma control. OBJECTIVE: Our systematic review and meta-analysis intends to evaluate the therapeutic efficacy and safety of benralizumab in patients with eosinophilic asthma. DATA SOURCES AND EXTRACTION: Literature searches of PubMed, Embase, and the Cochrane Library were performed to identify randomized controlled trials of benralizumab and clinic outcomes in asthmatics...
December 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29207999/corticosteroid-plus-%C3%AE-2-agonist-in-a-single-inhaler-as-reliever-therapy-in-intermittent-and-mild-asthma-a-proof-of-concept-systematic-review-and-meta-analysis
#10
REVIEW
Gang Wang, Xin Zhang, Hong Ping Zhang, Lei Wang, De Ying Kang, Peter J Barnes, Gang Wang
BACKGROUND: Current guidelines recommend a single inhaler maintenance and reliever therapy (SMART) regimen for moderate to severe asthma. However, evidence for the inhaled corticosteroid plus fast-onset-acting β2-agonist (ICS/FABA) as reliever therapy in management of intermittent and mild asthma patients is lacking. OBJECTIVE: To systematically explore efficacy and safety of the proof-of-concept of the ICS plus FABA regimen in a single inhaler as reliever therapy across children and adults with intermittent and mild persistent asthma...
December 6, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29206638/work-related-asthma-in-a-sample-of-subjects-with-established-asthma
#11
Donatella Talini, Alessandro Ciberti, Dusca Bartoli, Paolo Del Guerra, Tonina Enza Iaia, Maria Lemmi, Andrea Innocenti, Francesco Di Pede, Manuela Latorre, Laura Carrozzi, Pierluigi Paggiaro
OBJECTIVE: To assess the impact of occupational exposure to irritants or sensitizers on the occurrence, recrudescence and worsening of asthma and to identify unrecognized cases of work related asthma (WRA) including Work-Exacerbated Asthma (WEA) and Occupational Asthma (OA), in a general asthma clinic population sample. SETTING, DESIGN AND PARTICIPANTS: The study was a population-based cross sectional survey. 1289 asthmatic subjects (from 15 to 46 yrs old) living in a vast district of Tuscany (Italy) were identified from the Medical Reimbursement Register of the National Health System...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29206100/exploring-the-use-of-ingenol-mebutate-to-prevent-non-melanoma-skin-cancer
#12
Zarqa Ali
Asthma is a serious global health issue and the most prevalent chronic disorder among Danish pregnant women. Exacerbations of asthma during pregnancy have been associated with increased risk of adverse pregnancy and perinatal outcomes, and by that making asthma a potential serious medical condition during pregnancy. Monitoring of asthma every four to six weeks is recommended during pregnancy, although evidence is lacking that following this recommendation will improve pregnancy outcome and, not least, be beneficial for all pregnant women with asthma...
December 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29204851/fixed-versus-variable-practice-for-teaching-medical-students-the-management-of-pediatric-asthma-exacerbations-using-simulation
#13
David Drummond, Jennifer Truchot, Eleonora Fabbro, Pierre-François Ceccaldi, Patrick Plaisance, Antoine Tesnière, Alice Hadchouel
Simulation-based trainings represent an interesting approach to teach medical students the management of pediatric asthma exacerbations (PAEs). In this study, we compared two pedagogical approaches, training students once on three different scenarios of PAEs versus training students three times on the same scenario of PAE. Eighty-five third-year medical students, novice learners for the management of PAEs, were randomized and trained. Students were assessed twice, 1 week and 4 months after the training, on a scenario of PAE new to both groups and on scenarios used during the training...
December 4, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29204432/caspase-1-deficiency-reduces-eosinophilia-and-interleukin-33-in-an-asthma-exacerbation-model
#14
Mandy Menzel, Hamid Akbarshahi, Irma Mahmutovic Persson, Manoj Puthia, Leif Bjermer, Lena Uller
Rhinovirus infections are common triggers of asthma exacerbations. Viruses can activate the inflammasome, resulting in processing and activation of caspase-1. This recruitment triggers production of interleukin (IL)-1β and IL-18, which have been implicated in asthma. Elucidating the involvement of the inflammasome and its compartments, such as caspase-1, in asthma exacerbations is warranted. Gene expression of caspase-1 was measured in rhinovirus-infected primary bronchial epithelial cells of asthmatic and healthy donors 24 h post-infection...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29202118/emergency-department-asthma-medication-delivery-program-an-initiative-to-provide-discharge-prescriptions-and-education
#15
Kayla Durkin, Tricia Montgomery, Kristen Lamberjack, Cindy C Hafer, James Naprawa, Shannon Yarosz
Background: Prescription fill rates for children being discharged from the emergency department (ED) after asthma exacerbations are low, placing the child at risk for additional ED visits or admissions for asthma. This article describes the implementation of an ED asthma prescription delivery service designed to improve pharmacy prescription capture and decrease ED revisit rates. Methods: A core group developed a service to provide asthma prescriptions and education to patients in their ED room before discharge...
July 2017: Pediatric Quality & Safety
https://www.readbyqxmd.com/read/29199961/airway-epithelium-plays-a-leading-role-in-the-complex-framework-underlying-respiratory-allergy
#16
REVIEW
J C López-Rodríguez, S Benedé, R Barderas, M Villalba, E Batanero
Airway epithelium is the cellular structure with the greatest surface exposed to a plethora of environmental airborne substances, including microorganisms, respiratory viruses, air pollutants, and allergens. In addition to being a protective physical barrier at the air-liquid interface, the airway epithelium acts as an effective chemical and immunological barrier that plays a crucial role in orchestrating the immune response in the lungs, by supporting the activation, recruitment, and mobilization of immune cells...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29198875/gancao-gansui-combination-impacts-gut-microbiota-diversity-and-related-metabolic-functions
#17
Jingao Yu, Jianming Guo, Weiwei Tao, Pei Liu, Erxin Shang, Zhenhua Zhu, Xiuhe Fan, Juan Shen, Yongqing Hua, Kevin Yue Zhu, Yuping Tang, Jin-Ao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: The theory of "eighteen incompatible medicaments" (EIM) in traditional Chinese medicine (TCM) is the most representative case of herbal-herbal interactions. Gancao and Gansui are one of the incompatible herbal pairs in EIM. Gancao, also known as "licorice", is the most frequently used Chinese herb or food additive. Gansui, the root of Euphorbia kansui T.P. Wang, is another famous Chinese herb usually used to treat edema, ascites and asthma but could induce gastrointestinal (GI) tract irritation...
November 30, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29197099/identification-of-patterns-of-factors-preceding-severe-or-life-threating-asthma-exacerbations-in-a-nationwide-study
#18
H Tanaka, E Nakatani, Y Fukutom, K Sekiya, H Kaneda, M Iikura, M Yoshida, K Takahashi, K Tomii, M Nishikawa, N Kaneko, Y Sugino, M Shinkai, T Ueda, Y Tanikawa, T Shirai, M Hirabayashi, T Aoki, T Kato, K Iizuka, M Fujii, M Taniguchi
BACKGROUND: Reducing near-fatal asthma exacerbations is a critical problem in asthma management. OBJECTIVES: To determine patterns of factors preceding asthma exacerbations in a real-world setting. METHODS: In a nationwide prospective study of 190 patients who had experienced near-fatal asthma exacerbation, cluster analysis was performed using asthma symptoms over the two-week period before admission. RESULTS: Three distinct clusters of symptoms were defined employing the self-reporting of a visual analogue scale...
December 1, 2017: Allergy
https://www.readbyqxmd.com/read/29196148/circulating-il-17-producing-mucosal-associated-invariant-t-cells-mait-are-associated-with-symptoms-in-children-with-asthma
#19
Guillaume Lezmi, Rola Abou Taam, Céline Dietrich, Lucienne Chatenoud, Jacques de Blic, Maria Leite-de-Moraes
IL-17 and mucosal-associated invariant T (MAIT) cells have been involved in asthma pathogenesis. However, IL-17-producing MAIT cells (MAIT-17) were not evidenced. We aimed to determine whether circulating MAIT-17 were detectable in children with asthma, and whether they correlated with asthma symptoms or lung function. Children from the SPASM cohort of preschoolers with severe wheeze were reassessed for asthma at school age, and categorized as exacerbators (1 or more severe exacerbations in the previous 12months) or non-exacerbators...
November 28, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29196085/technology-interventions-for-nonadherence-new-approaches-to-an-old-problem
#20
Bruce G Bender
Nonadherence to asthma medications is well recognized. Interventions to improve adherence, however, have been only moderately successful and are not often adopted because of limited provider time, training, or institutional support. The potential for mobile communication technology to improve adherence has gathered sharply growing interest. Technology-based adherence tracking devices have been in existence for almost 3 decades, but have only recently reached a level of reliability and utility to be considered in allergy practice...
November 29, 2017: Journal of Allergy and Clinical Immunology in Practice
keyword
keyword
23347
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"