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https://www.readbyqxmd.com/read/28103612/a-phase-iii-randomised-controlled-trial-of-erlotinib-vs-gefitinib-in-advanced-non-small-cell-lung-cancer-with-egfr-mutations
#1
J J Yang, Q Zhou, H H Yan, X C Zhang, H J Chen, H Y Tu, Z Wang, C R Xu, J Su, B C Wang, B Y Jiang, X Y Bai, W Z Zhong, X N Yang, Y L Wu
BACKGROUND: A phase III trial was conducted to compare the safety and efficacy of erlotinib with that of gefitinib in advanced non-small cell lung cancer harbouring epidermal growth factor receptor mutations in exon 19 or 21. METHODS: Eligible patients were randomised to receive erlotinib (150 mg per day) or gefitinib (250 mg per day) orally until disease progression or unacceptable toxicity. We aimed to determine whether erlotinib is superior to gefitinib in efficacy...
January 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28103611/phase-ii-randomised-discontinuation-trial-of-the-met-vegf-receptor-inhibitor-cabozantinib-in-metastatic-melanoma
#2
Adil Daud, Harriet M Kluger, Razelle Kurzrock, Frauke Schimmoller, Aaron L Weitzman, Thomas A Samuel, Ali H Moussa, Michael S Gordon, Geoffrey I Shapiro
BACKGROUND: A phase II randomised discontinuation trial assessed cabozantinib (XL184), an orally bioavailable inhibitor of tyrosine kinases including VEGF receptors, MET, and AXL, in a cohort of patients with metastatic melanoma. METHODS: Patients received cabozantinib 100 mg daily during a 12-week lead-in. Patients with stable disease (SD) per Response Evaluation Criteria in Solid Tumours (RECIST) at week 12 were randomised to cabozantinib or placebo. Primary endpoints were objective response rate (ORR) at week 12 and postrandomisation progression-free survival (PFS)...
January 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28103590/risk-factors-for-intrapartum-fever-in-term-gestations-and-associated-maternal-and-neonatal-sequelae
#3
Angela P H Burgess, Justin E Katz, Michael Moretti, Nisha Lakhi
AIM: To determine factors associated with intrapartum fever and to examine associated maternal and neonatal outcomes. METHODS: Retrospective study of patients between 360/7 and 420/7 gestational weeks who entered spontaneous or induced active labor and developed temperature ≥38°C; a similar group that did not develop fever were controls. Univariate and multivariate analyses were performed with p < 0.05 as significant. RESULTS: Fifty-four febrile patients and 306 nonfebrile controls met inclusion criteria...
January 20, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28103414/a-meta-analysis-of-the-association-between-appraisals-of-trauma-and-posttraumatic-stress-in-children-and-adolescents
#4
Ryan Mitchell, Kate Brennan, David Curran, Donncha Hanna, Kevin F W Dyer
Cognitive models of posttraumatic stress disorder (PTSD) place an emphasis on the role of negative appraisals of traumatic events. It is suggested that the way in which the event is appraised determines the extent to which posttraumatic stress symptoms will be experienced. Therefore, a strong relationship between trauma appraisals and symptoms of PTSD might be expected. However, this relationship is not as firmly established in the child and adolescent literature. A systematic literature review of this relationship returned 467 publications, of which 11 met full eligibility criteria...
January 19, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28103413/parental-orders-and-the-rights-of-surrogate-mothers
#5
Nathan Hodson, Susan Bewley
Obstetricians need to be aware of potential legal changes which may impact the doctor-patient relationship in surrogacy cases. Presently, English law recognises the surrogate as the mother. After giving birth, she may hand over the baby. The commissioning couple then apply for Parental Orders and become legal parents if the conditions in the Surrogacy Arrangements Act 1985 are met. This article is protected by copyright. All rights reserved.
January 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28103324/use-of-proton-pump-inhibitors-predicts-heart-failure-and-death-in-patients-with-coronary-artery-disease
#6
Ana María Pello Lázaro, Carmen Cristóbal, Juan Antonio Franco-Peláez, Nieves Tarín, Álvaro Aceña, Rocío Carda, Ana Huelmos, María Luisa Martín-Mariscal, Jesús Fuentes-Antras, Juan Martínez-Millá, Joaquín Alonso, Óscar Lorenzo, Jesús Egido, Lorenzo López-Bescós, José Tuñón
OBJECTIVES: Proton-pump inhibitors (PPIs) seem to increase the incidence of cardiovascular events in patients with coronary artery disease (CAD), mainly in those using clopidogrel. We analysed the impact of PPIs on the prognosis of patients with stable CAD. METHODS: We followed 706 patients with CAD. Primary outcome was the combination of secondary outcomes. Secondary outcomes were 1) acute ischaemic events (any acute coronary syndrome, stroke, or transient ischaemic attack) and 2) heart failure (HF) or death...
2017: PloS One
https://www.readbyqxmd.com/read/28103230/conspicuity-of-malignant-lesions-on-pet-ct-and-simultaneous-time-of-flight-pet-mri
#7
Ryogo Minamimoto, Andrei Iagaru, Mehran Jamali, Dawn Holley, Amir Barkhodari, Shreyas Vasanawala, Greg Zaharchuk
PURPOSE: To compare the conspicuity of malignant lesions between FDG PET/CT and a new simultaneous, time-of-flight (TOF) enabled PET/MRI scanner. METHODS: All patients underwent a single-injection of FDG, followed by a dual imaging protocol consisting of PET/CT followed by TOF PET/MRI. PET/CT and PET/MRI images were evaluated by two readers independently for areas of FDG uptake compatible with malignancy, and then categorized into 5 groups (1: PET/MRI and PET/CT positive; 2: PET/MRI positive, PET/CT positive in retrospect; 3: PET/CT positive, PET/MRI positive in retrospect; 4: PET/MRI positive, PET/CT negative; 5: PET/MRI negative, PET/CT positive) by consensus...
2017: PloS One
https://www.readbyqxmd.com/read/28103163/the-prevalence-of-biofilms-in-chronic-wounds-a-systematic-review-and-meta-analysis-of-published-data
#8
M Malone, T Bjarnsholt, A J McBain, G A James, P Stoodley, D Leaper, M Tachi, G Schultz, T Swanson, R D Wolcott
The presence of biofilms in chronic non-healing wounds, has been identified through in vitro model and in vivo animal data. However, human chronic wound studies are under-represented and generally report low sample sizes. For this reason we sought to ascertain the prevalence of biofilms in human chronic wounds by undertaking a systematic review and meta-analysis. Our initial search identified 554 studies from the literature databases (Cochrane Library, Embase, Medline). After removal of duplicates, and those not meeting the requirements of inclusion, nine studies involving 185 chronic wounds met the inclusion criteria...
January 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28103155/using-art-in-an-intergenerational-program-to-improve-students-attitudes-toward-people-with-dementia
#9
Elizabeth Lokon, Yue Li, Jyotsana Parajuli
This study explored the effects of participating in an intergenerational service learning program called Opening Mind through Arts (OMA) on college students' attitudes toward people with dementia. In this program, students were paired one-on-one with elders who have dementia to support the elders' creation of visual art projects. They met weekly for one semester. The Dementia Attitude Scale was administered at the beginning and end of the semester to measure changes in students' attitudes. The study included 156 students participating in OMA and assessed if their participation makes a difference in the degree of change in overall attitudes, knowledge and comfort level toward people with dementia...
January 19, 2017: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/28102641/evidence-of-a-reduction-over-time-in-the-behavioral-severity-of-autistic-disorder-diagnoses
#10
Andrew J O Whitehouse, Matthew N Cooper, Keely Bebbington, Gail Alvares, Ashleigh Lin, John Wray, Emma J Glasson
The increasing prevalence of Autism Spectrum Disorders (ASD) may in part be due to a shift in the diagnostic threshold that has led to individuals with a less severe behavioral phenotype receiving a clinical diagnosis. This study examined whether there were changes over time in the qualitative and quantitative phenotype of individuals who received the diagnosis of Autistic Disorder. Data were from a prospective register of new diagnoses in Western Australia (n = 1252). From 2000 to 2006, we examined differences in both the percentage of newly diagnosed cases that met each criterion as well as severity ratings of the behaviors observed (not met, partially met, mild/moderate and extreme)...
January 19, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28102561/stressful-life-events-and-catechol-o-methyl-transferase-comt-gene-in-bipolar-disorder
#11
Georgina M Hosang, Helen L Fisher, Sarah Cohen-Woods, Peter McGuffin, Anne E Farmer
BACKGROUND: A small body of research suggests that gene-environment interactions play an important role in the development of bipolar disorder. The aim of the present study is to contribute to this work by exploring the relationship between stressful life events and the catechol-O-methyl-transferase (COMT) Val(158) Met polymorphism in bipolar disorder. METHODS: Four hundred eighty-two bipolar cases and 205 psychiatrically healthy controls completed the List of Threatening Experiences Questionnaire...
January 19, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28102532/time-to-epinephrine-in-out-of-hospital-cardiac-arrest-a-retrospective-analysis-of-intraosseous-versus-intravenous-access
#12
Elliot M Ross, Julian Mapp, Chetan Kharod, David A Wampler, Christopher Velasquez, David A Miramontes
INTRODUCTION: The 2015 advanced cardiac life support update continues to advocate administering epinephrine during cardiac arrest. The goal of our study is to determine if prehospital intraosseous (IO) access results in shorter time to epinephrine than prehospital peripheral intravenous (PIV) access. METHODS: The out-of-hospital cardiac arrest (OHCA) database of a large, urban, fire-based emergency medical services system was searched for consecutive cases of OHCA between January 2013 and December 2015...
April 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28102489/genetic-variants-and-anterior-cruciate-ligament-rupture-a-systematic-review
#13
REVIEW
Mustafa Kaynak, Frank Nijman, Joyce van Meurs, Max Reijman, Duncan E Meuffels
BACKGROUND: Studies have shown a familial predisposition for anterior cruciate ligament (ACL) rupture and have been followed by genetic-association studies on polymorphisms in candidate genes in recent years. To date, no systematic review with a best-evidence synthesis has evaluated the influence of genetics on this devastating knee injury. OBJECTIVE: Our objective was to evaluate the association between genetic variants and ACL rupture. METHODS: We performed an extensive search in Embase, MEDLINE, Web of Science, Scopus, PubMed Publisher, Cochrane Register of Clinical Trials, and Google scholar up to 24 August 2015...
January 19, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28102488/performance-and-side-effects-of-supplementation-with-n-acetylcysteine-a-systematic-review-and-meta-analysis
#14
REVIEW
Kate Rhodes, Andrea Braakhuis
BACKGROUND: N-Acetylcysteine (NAC) is a promising antioxidant supplement with potential as an acute strategy to enhance performance in elite sport, but there are concerns about its side effects with high doses. OBJECTIVE: To review the current literature and evaluate the effects of NAC supplementation on sport performance and the risk of adverse effects. METHODS: The literature up to May 2016 was searched on MEDLINE (PubMed), EMBASE, SPORTDiscus, Google Scholar and Scopus databases to identify all studies investigating the effects of NAC supplementation on exercise performance and/or side effects experienced...
January 19, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28102154/effectiveness-of-treatment-of-idiopathic-scoliosis-by-spinecor-dynamic-bracing-with-special-physiotherapy-programme-in-spinecor-system
#15
Karina Rożek, Tomasz Potaczek, Maja Zarzycka, Ewa Lipik, Barbara Jasiewicz
BACKGROUND: The SpineCor dynamic brace for the treatment of idiopathic scoliosis is designed to maintain the correct position of the spine and a new movement strategy for 20 hours per day. The SpineCor exercise system intensifies and complements the brace treatment. This study evaluated the effectiveness of a comprehensive treatment of idiopathic scoliosis involving the SpineCor system. MATERIAL AND METHODS: The study assessed a group of 40 patients (38 girls and 2 boys) with idiopathic scoliosis treated with the SpineCor brace...
October 28, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28102153/manual-therapy-in-the-treatment-of-idiopathic-scoliosis-analysis-of-current-knowledge
#16
Dariusz Czaprowski
BACKGROUND: Apart from the recommended specific physiotherapy, the treatment of idiopathic scoliosis (IS) also incorporates non-specific manual therapy (NMT). The aim of this paper is to assess the efficacy of NMT (manual therapy, chiropractic, osteopathy) used in the treatment of children and adolescents with IS. MATERIAL AND METHODS: The study analysed systematic reviews (Analysis 1) and other recent scientific publications (Analysis 2). Analysis 1 encompassed papers on the use of NMT in patients with IS...
October 28, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28102100/a-systematic-review-the-influence-of-real-time-feedback-on-wheelchair-propulsion-biomechanics
#17
Andrew Symonds, Giulia Barbareschi, Stephen Taylor, Catherine Holloway
BACKGROUND: Clinical guidelines recommend that, in order to minimize upper limb injury risk, wheelchair users adopt a semi-circular pattern with a slow cadence and a large push arc. OBJECTIVES: To examine whether real time feedback can be used to influence manual wheelchair propulsion biomechanics. REVIEW METHODS: Clinical trials and case series comparing the use of real time feedback against no feedback were included. A general review was performed and methodological quality assessed by two independent practitioners using the Downs and Black checklist...
January 19, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28102020/families-experiences-of-involvement-in-care-planning-in-mental-health-services-an-integrative-literature-review
#18
REVIEW
Owen Doody, Mary Pat Butler, Rosemary Lyons, Daniel Newman
INTRODUCTION: Mental health service policy stipulates that family carers be involved in care planning. AIM: To identify families experiences of care planning involvement in adult mental health services. METHOD: An integrative review where electronic databases and grey literature were searched for papers published between 01 Jan 2005 and 10 February 2016. RESULTS: Fifteen papers met the inclusion criteria. Thematic analysis generated three themes: (1)families experience of collaboration, (2)families perceptions of professionals and (3)families impressions of the care planning process...
January 19, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28101972/an-evaluation-of-the-quality-of-evidence-available-to-inform-current-bone-conduction-hearing-device-national-policy
#19
Rishi Mandavia, Alex Carter, Nadine Haram, Elias Mossialos, Anne Gm Schilder
OBJECTIVES: In 2016 NHS England published the commissioning policy on Bone Conducting Hearing Devices (BCHDs). This policy was informed by updated evidence on the clinical and cost effectiveness of BCHDs as well as by the 2013 Bone Anchored Hearing Aid (BAHA) policy. Commissioning policies set the criteria for service delivery and therefore have a major impact on the care received by patients. It is important that stakeholders have a good appreciation of the available evidence informing policy, since this will promote engagement both with the policy as well as with future research leading on from the policy...
January 18, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28101953/associations-between-participation-in-family-activities-and-adolescent-school-problems
#20
S S Goldfarb, J L Locher, J Preskitt, D Becker, S L Davies, B Sen
INTRODUCTION: Adolescent risk outcomes related to school issues are widespread, with about 20% parents reporting poor school engagement amongst their youth. Previous literature suggests that adolescents who report strong bonds with their parents are often identified as being less likely to engage in risky behaviours, such as substance use. The current study sought to examine the association between the frequencies of selected family activities and school problems amongst adolescents after adjustments for family connectedness and other characteristics...
January 18, 2017: Child: Care, Health and Development
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