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https://www.readbyqxmd.com/read/29906794/development-of-a-hybrid-course-on-wheelchair-service-provision-for-clinicians-in-international-contexts
#1
Yohali Burrola-Mendez, Mary Goldberg, Rachel Gartz, Jon Pearlman
INTRODUCTION: Wheelchair users worldwide are at high risk of developing secondary health conditions and premature death due to inappropriate wheelchair provision by untrained providers. The International Society of Wheelchair Professionals (ISWP) has developed a Hybrid Course based on the World Health Organization's Wheelchair Service Training Package-Basic Level. The Hybrid Course leverages online modules designed for low-bandwidth internet access that reduces the in-person training exposure from five to three and a half days, making it less expensive and more convenient for both trainees and trainers...
2018: PloS One
https://www.readbyqxmd.com/read/29906718/review-adjunctive-pharmacologic-approaches-for-benzodiazepine-tapers
#2
REVIEW
Justine W Welsh, Valeria Tretyak, R Kathryn McHugh, Roger D Weiss, Olivera Bogunovic
BACKGROUND: Many patients require discontinuation of benzodiazepines due to a reduction in drug efficacy over time, the development of a sedative use disorder, or unwanted side effects. Benzodiazepine discontinuation can pose a significant challenge for prescribing clinicians due to potential withdrawal symptoms and a recurrence of psychiatric complaints. METHODS: A PubMed literature search was conducted using the medical subject heading of benzodiazepines in combination with the following key words: discontinuation, withdrawal, detoxification, cessation, dependence, addiction, substance use disorders, or long term...
May 31, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29906700/patient-characteristics-and-treatment-patterns-in-patients-with-newly-diagnosed-epilepsy-a-us-database-analysis
#3
Edward Faught, Sandra Helmers, David Thurman, Hyunmi Kim, Linda Kalilani
OBJECTIVE: The objective of this study was to determine patient characteristics and antiepileptic drug (AED) treatment patterns in patients with newly diagnosed epilepsy in a United States (US) population followed for ≥180 days. METHODS: In this retrospective cohort study, Commercial, Supplemental Medicare, and Medicaid insurance claims from US-based Truven Health MarketScan® claims database were analyzed for incident epilepsy cases (index date: January 2010-June 2013; prior baseline of 2 years [1 year for ages 1 to <2 years; none for those <1 year])...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29906699/causes-of-mortality-in-early-infantile-epileptic-encephalopathy-a-systematic-review
#4
REVIEW
Graciane Radaelli, Francisco de Souza Santos, Wyllians Vendramini Borelli, Leonardo Pisani, Magda Lahorgue Nunes, Fulvio Alexandre Scorza, Jaderson Costa da Costa
INTRODUCTION: Early infantile epileptic encephalopathy syndrome (EIEE), also known as Ohtahara syndrome, is an age-dependent epileptic encephalopathy syndrome defined by clinical features and electroencephalographic findings. Epileptic disorders with refractory seizures beginning in the neonatal period and/or early infancy have a potential risk of premature mortality, including sudden death. We aimed to identify the causes of death in EIEE and conducted a literature survey of fatal outcomes...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29906580/posterior-lumbar-interbody-fusion-vs-dynamic-hybrid-instrumentation-a-prospective-randomised-clinical-trial
#5
C Herren, M Simons, J Bredow, S Oikonomidis, L Westermann, R Sobottke, M J Scheyerer, M Pishnamaz, P Eysel, K Zarghooni, J Franklin, J Siewe
PURPOSE: The purpose of this study was to assess the radiological and clinical outcomes following lumbar fusion intervention and to compare both, the established posterior lumbar interbody fusion (PLIF)-technique and the dynamic hybrid instrumentation ('topping off'). METHODS: In this prospective randomised trial all patients presented with degenerative changes to the lumbar spine (L2-S1) were included and randomised in two groups: patients who underwent the 360°-fusion procedure in PLIF-technique (1, control group) and those patients who underwent fusion surgery with additional hybrid instrumentation (DTO, Zimmer, Inc...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29906567/assessment-of-posaconazole-salvage-therapy-in-chronic-pulmonary-aspergillosis-by-using-predefined-response-criteria
#6
Isabel Rodriguez-Goncer, Chris Harris, Chris Kosmidis, Eavan G Muldoon, Pippa J Newton, David W Denning
OBJECTIVE: Chronic pulmonary aspergillosis (CPA) is a progressive infection that destroys lung tissue in non-immunocompromised patients. First line therapies for CPA (itraconazole and/or voriconazole) are often curtailed due to toxicity or the development of drug resistance. Posaconazole is a potential alternative for these patients. METHODS: Use of posaconazole was funded by the NHS Highly Specialised National Commissioners on an individual basis for patients who failed or did not tolerate first line therapy; those who met predefined criteria for improvement at 4 and 6 months (weight gain and/or improvement in St George's Respiratory Questionnaire) continued posaconazole long-term...
June 12, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29906433/complex-robotic-lower-urinary-tract-surgeries-in-patients-with-previous-open-surgery
#7
Patricio C Gargollo, Candace Granberg, Edward Gong, Duong Tu, Benjamin Whittam, Daniel Dajusta
PURPOSE: We describe our experience with robot assisted complex lower urinary tract reconstruction (CUTR) in patients with previous open abdominal surgery (PAS). MATERIALS AND METHODS: Patients with any PAS undergoing robot assisted CUTR were included. CUTR was defined as bladder neck reconstruction (BNR) or continent catheterizable conduits (CCC) or both, redo surgery at the bladder neck for persistent incontinence, or any of the above with an antegrade enema channel creation (MACE)...
June 12, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29906133/element-selectivity-in-second-harmonic-generation-of-gafeo_-3-by-a-soft-x-ray-free-electron-laser
#8
Sh Yamamoto, T Omi, H Akai, Y Kubota, Y Takahashi, Y Suzuki, Y Hirata, K Yamamoto, R Yukawa, K Horiba, H Yumoto, T Koyama, H Ohashi, S Owada, K Tono, M Yabashi, E Shigemasa, S Yamamoto, M Kotsugi, H Wadati, H Kumigashira, T Arima, S Shin, I Matsuda
Nonlinear optical frequency conversion has been challenged to move down to the extreme ultraviolet and x-ray region. However, the extremely low signals have allowed researchers to only perform transmission experiments of the gas phase or ultrathin films. Here, we report second harmonic generation (SHG) of the reflected beam of a soft x-ray free-electron laser from a solid, which is enhanced by the resonant effect. The observation revealed that the double resonance condition can be met by absorption edges for transition metal oxides in the soft x-ray range, and this suggests that the resonant SHG technique can be applicable to a wide range of materials...
June 1, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29905785/healthcare-services-for-syrian-refugees-in-jordan-a-systematic-review
#9
R El Arab, M Sagbakken
Background: This review aims to explore the healthcare needs and access to healthcare services among Syrian refugees in Jordan. Furthermore, it identifies possible ways of responding to such needs within the framework of the structural challenges faced in this particular context. Methods: Through qualitative techniques, this study systematically reviewed nine articles identified in academic and international organizations' databases. Six articles are from scholarly sources, while three are published reports or commentary articles; thus, there are variations in methodological rigour...
June 13, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29905618/repeated-measures-designs-and-analysis-of-longitudinal-data-if-at-first-you-do-not-succeed-try-try-again
#10
Patrick Schober, Thomas R Vetter
Anesthesia, critical care, perioperative, and pain research often involves study designs in which the same outcome variable is repeatedly measured or observed over time on the same patients. Such repeatedly measured data are referred to as longitudinal data, and longitudinal study designs are commonly used to investigate changes in an outcome over time and to compare these changes among treatment groups. From a statistical perspective, longitudinal studies usually increase the precision of estimated treatment effects, thus increasing the power to detect such effects...
June 12, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29905617/impact-of-clinical-guidelines-on-revisits-after-ambulatory-pediatric-adenotonsillectomy
#11
Helen H Lee, Nicholas M Dalesio, Anthony T Lo Sasso, William C Van Cleve
BACKGROUND: Pediatric adenotonsillectomies are common and carry known risks of potentially severe complications. Complications that require a revisit, to either the emergency department or hospital readmission, increase costs and may be tied to lower reimbursements by federal programs. In 2011 and 2012, recommendations by pediatric and surgical organizations regarding selection of candidates for ambulatory procedures were issued. We hypothesized that guideline-associated changes in practice patterns would lower the odds of revisits...
June 12, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29905592/sex-education-and-hiv-testing-among-young-men-who-have-sex-with-men-findings-from-the-2006-2010-and-2011-2015-national-survey-of-family-growth
#12
Jace D Pierce, Kelly R Ylitalo, Beth A Lanning, Christine C Limbers
BACKGROUND: Young men who have sex with men (YMSM) are disproportionally affected by HIV and exhibit low levels of HIV testing. The purpose of this study was to examine the relationship between sex education and subsequent HIV testing among YMSM. METHODS: Data from sexually active men aged 15-24 years at interview in the 2006-2010 or 2011-2015 National Survey of Family Growth. Sex education included three contexts (formal institutions [e.g., schools], parents, and healthcare providers) and specific topics...
June 12, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29905556/association-between-components-of-metabolic-syndrome-and-cognitive-dysfunction-cross-sectional-study-among-the-population-of-the-turkestan-region
#13
K Madenbay, Zh Shalkharova, Zh Shalkharova, G Nuskabayeva, K Sadykova
Metabolic syndrome (MetS) being a risk factor for many vascular pathologic processes is associated with cognitive dysfunction with vascular genesis. Objective - to study the relationship between clinical and metabolic indicators and the presence of cognitive dysfunction in persons with MetS. A transverse study was conducted in the Turkestan region of Southern Kazakhstan during which a general clinical, laboratory examination and evaluation of cognitive function was performed in 639 patients. To assess the relationship between the MetS, its individual components and cognitive function with Mini Mental State Examination test (MMSE) multinominal logistic regression analysis was used...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905044/-correlation-analysis-between-interleukin-6-polymorphism-and-adolescent-idiopathic-scoliosis-susceptibility-and-bracing-effectiveness
#14
Junsheng Gao, Lu Zhang, Zhiang Liu, Shuaihui Yao, Songming Gao
Objective: To analyze the correlation between the polymorphism on interleukin 6 (IL-6) gene promoter region-174 locus and adolescent idiopathic scoliosis (AIS), including the susceptibility, the bracing effectiveness, and the possible mechanism. Methods: The 182 AIS patients and 210 healthy controls who met the inclusion criteria between January 2013 and January 2016 were collected as research objects. The genotype of IL-6 gene promoter region-174 locus, the serum IL-6, the bone mineral density (BMD) of femoral neck and vertebrae (L 1-4 ), and the bone metabolism parameters, including bone alkaline phosphatase (BALP), bone gla protein (BGP), tartrate resistant acid phosphatase 5b (TRACP-5b), urine Ca, and urine Ca/Cr, were detected...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29905036/feasibility-of-using-negative-ultrasonography-results-of-axillary-lymph-nodes-to-predict-sentinel-lymph-node-metastasis-in-breast-cancer-patients
#15
Xue Chen, Yingjian He, Jiwei Wang, Ling Huo, Zhaoqing Fan, Jinfeng Li, Yuntao Xie, Tianfeng Wang, Tao Ouyang
Knowledge of the pathology of axillary lymph nodes (ALN) in breast cancer patients is critical for determining their treatment. Ultrasound is the best noninvasive evaluation for the ALN status. However, the correlation between negative ultrasound results and the sentinel lymph nodes (SLN) pathology remains unknown. To test the hypothesis that negative ultrasound results of ALN predict the negative pathology results of SLN in breast cancer patients, we assessed the association between ALN ultrasonography-negative results and the SLN pathology in 3115 patients with breast cancer recruited between October 2010 and April 2016 from a single cancer center, prospective database...
June 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29905009/history-of-gestational-diabetes-and-future-cardiovascular-disease-what-have-we-learned
#16
Cherng-Lan Hsu, Wayne H-H Sheu
It is well established that history of gestational diabetes mellitus (GDM) will increase risks of developing metabolic syndrome (MetS) and type 2 diabetes mellitus (DM) and often subsequently link to future risk of cardiovascular disease (CVD). Recommendations from The American Diabetes Association (ADA) indicates that GDM is one of risk factors for future CVD in women based on previous evidence showing strong associations between GDM and CVD, such as myocardial infarction and stroke1 . However, most of those relationships were obtained from analysis of retrospective data...
June 15, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29905001/healing-criteria-how-should-be-defined-an-episode-of-benign-paroxistic-positional-vertigo-of-posterior-semicircular-canal-s-resolution-prospective-observational-study
#17
G Guerra-Jiménez, E Domènech-Vadillo, M G Álvarez-Morujo de Sande, R González-Aguado, H Galera-Ruiz, C Morales Angulo, A J Martín-Mateos, E Figuerola-Massana, Á Ramos-Macías, E Domínguez-Durán
OBJECTIVES: To compare the outcome of the Epley maneuver (EM) in benign paroxysmal positional vertigo of the posterior canal (CSP-BPPV) depending on the definition used for recovery. DESIGN: Multicenter observational prospective study. SETTING: Otoneurology Units of five tertiary reference hospitals. PARTICIPANTS: All patients presenting with unilateral CSP-BPPV assisted for one-year period. EXCLUSION CRITERIA: Spontaneous nystagmus, positive McClure-Pagnini maneuver, positive bilateral Dix-Hallpike maneuver (DHM), positive DHM for vertigo but negative for nystagmus and atypical nystagmus...
June 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29904935/physical-activity-and-the-risk-of-colorectal-cancer-in-lynch-syndrome
#18
S Ghazaleh Dashti, Aung Ko Win, Sheetal S Hardikar, Stephen E Glombicki, Sheila Mallenahalli, Selvi Thirumurthi, Susan K Peterson, Y Nancy You, Daniel D Buchanan, Jane C Figueiredo, Peter T Campbell, Steven Gallinger, Polly A Newcomb, John D Potter, Noralane M Lindor, Loic Le Marchand, Robert W Haile, John L Hopper, Mark A Jenkins, Karen M Basen-Engquist, Patrick M Lynch, Mala Pande
Greater physical activity is associated with a decrease in risk of colorectal cancer for the general population; however, little is known about its relationship with colorectal cancer risk for people with Lynch syndrome, carriers of inherited pathogenic mutations in genes affecting DNA mismatch repair (MMR). We studied a cohort of 2,042 MMR gene mutations carriers (n=807, diagnosed with colorectal cancer), from the Colon Cancer Family Registry. Self-reported physical activity in three age-periods (20-29, 30-49, and ≥50 years) was summarized as average metabolic equivalent of task hours per week (MET-h/week) during the age-period of cancer diagnosis or censoring (near-term exposure), and across all age-periods preceding cancer diagnosis or censoring (long-term exposure)...
June 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29904805/economic-evaluation-of-patient-navigation-programs-in-colorectal-cancer-care-a-systematic-review
#19
REVIEW
Chloé Gervès-Pinquié, Anne Girault, Serena Phillips, Sarah Raskin, Mandi Pratt-Chapman
Patient navigation has expanded as a promising approach to improve cancer care coordination and patient adherence. This paper addresses the need to identify the evidence on the economic impact of patient navigation in colorectal cancer, following the Health Economic Evaluation Publication Guidelines. Articles indexed in Medline, Cochrane, CINAHL, and Web of Science between January 2000 and March 2017 were analyzed. We conducted a systematic review of the literature using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
June 14, 2018: Health Economics Review
https://www.readbyqxmd.com/read/29904797/hyaluronic-acid-hydrogels-incorporating-platelet-lysate-enhance-human-pulp-cell-proliferation-and-differentiation
#20
Leopoldina D F Almeida, Pedro S Babo, Cristiana R Silva, Márcia T Rodrigues, Josimeri Hebling, Rui L Reis, Manuela E Gomes
The restoration of dentine-pulp complex remains a challenge for dentists; nonetheless, it has been poorly addressed. An ideal system should modulate the host response, as well as enable the recruitment, proliferation and differentiation of relevant progenitor cells. Herein was proposed a photocrosslinkable hydrogel system based on hyaluronic acid (HA) and platelet lysate (PL). PL is a cocktail of growth factors (GFs) and cytokines involved in wound healing orchestration, obtained by the cryogenic processing of platelet concentrates, and was expected to provide the HA hydrogels specific biochemical cues to enhance pulp cells' recruitment, proliferation and differentiation...
June 14, 2018: Journal of Materials Science. Materials in Medicine
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