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https://www.readbyqxmd.com/read/29786111/high-glucose-suppresses-the-viability-and-proliferation-of-htr%C3%A2-8-svneo-cells-through-regulation-of-the-mir%C3%A2-137-prkaa1-il%C3%A2-6-axis
#1
Hai-Yan Peng, Ming-Qing Li, Hua-Ping Li
The aim of the present study was to investigate the mechanism underlying the high glucose (HG)‑associated regulation of HTR‑8/SVneo cell viability and proliferation during gestational diabetes mellitus (GDM), and to verify the association of microRNA (miR)‑137, protein kinase AMP‑activated catalytic subunit α1 (PRKAA1) and interlukin‑6 (IL‑6). miR‑137‑overexpressing and negative control HTR‑8/SVneo cells were established by lentiviral vector infection. Cell Counting Kit‑8 and colony formation assays were used to analyze the viability and proliferation of HTR‑8/SVneo cells...
May 17, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29785872/effect-evaluation-on-use-of-bedside-fiber-bronchoscope-in-treating-stroke-associated-pneumonia
#2
Qiu Han, Chun Chen, Hai-Qin Hu, Jun Shen, Guang Yang, Bin Chen, Lei Xia
Background The bedside fiber bronchoscope has been widely used in the diagnosis and treatment of respiratory disease. This study aims to assess the effect of using bedside fiber bronchoscope in sputum suction and alveolar lavage for treatment of stroke-associated pneumonia (SAP), compared with the use of conventional suction catheter. Methods One hundred and six patients with SAP were randomly divided into control group (n = 53) and experimental group (n = 53) for a controlled study. Patients in the two groups were conventionally treated with phlegm-resolving and anti-infective therapy...
May 22, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29785015/frequent-transmission-of-the-mycobacterium-tuberculosis-beijing-lineage-and-positive-selection-for-the-esxw-beijing-variant-in-vietnam
#3
Kathryn E Holt, Paul McAdam, Phan Vuong Khac Thai, Nguyen Thuy Thuong Thuong, Dang Thi Minh Ha, Nguyen Ngoc Lan, Nguyen Huu Lan, Nguyen Thi Quynh Nhu, Hoang Thanh Hai, Vu Thi Ngoc Ha, Guy Thwaites, David J Edwards, Artika P Nath, Kym Pham, David B Ascher, Jeremy Farrar, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Maxine Caws, Sarah J Dunstan
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data identify an underlying burden of disease caused by the endemic Mtb lineage 1 associated with the activation of long-term latent infection, and a threefold higher burden associated with the more recently introduced Beijing lineage and lineage 4 Mtb strains. We find that Beijing lineage Mtb is frequently transferred between Vietnam and other countries, and detect higher levels of transmission of Beijing lineage strains within this host population than the endemic lineage 1 Mtb...
May 21, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29784578/quantitative-study-about-the-role-of-environmental-conditions-in-the-survival-capability-of-multidrug-resistant-bacteria
#4
Adrienn Hanczvikkel, Ákos Tóth
BACKGROUND: Healthcare-associated infections (HAIs) caused by multidrug-resistant bacteria (MDRB) are of global concern and hospital textiles can contribute to their transmission. MDRB are able to survive on textiles for more than enough time to spread in the environment. Some studies summarized the effect of environmental factors on the duration of bacterial survival, but it remained an open question how these factors influence the quantity of surviving bacteria in a period of a few days, which is relevant from the perspective of HAIs...
May 18, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29781463/hepatic-arterial-infusion-pump-complications-and-nursing-management-regarding-use-in-patients-with-colorectal-cancer
#5
Deborah Italiano
BACKGROUND: The hepatic arterial infusion (HAI) pump is a treatment-delivery method based on the principle of targeting the tumor site directly and can be used alone or in combination with systemic chemotherapy. OBJECTIVES: The intent of this article is to serve as a resource for oncology nurses to safely identify and manage HAI pump complications. These complications include seroma, flipped HAI pump, infection, changes in pressure and temperature, challenging access, dry pump, high residual volume, chemical hepatitis, risk of ulcer, and radiologic imaging considerations...
June 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29777223/card9-s12n-facilitates-the-production-of-il-5-by-alveolar-macrophages-for-the-induction-of-type-2-immune-responses
#6
Xia Xu, Jin-Fu Xu, Guoxing Zheng, Hai-Wen Lu, Jie-Lin Duan, Wei Rui, Jian-Hong Guan, Li-Qing Cheng, Dan-Dan Yang, Ming-Chao Wang, Quan-Zhen Lv, Jian-Xiong Li, Xueqiang Zhao, Chun-Xia Chen, Peng Shi, Xin-Ming Jia, Xin Lin
The adaptor CARD9 functions downstream of C-type lectin receptors (CLRs) for the sensing of microbial infection, which leads to responses by the TH 1 and TH 17 subsets of helper T cells. The single-nucleotide polymorphism rs4077515 at CARD9 in the human genome, which results in the substitution S12N (CARD9S12N ), is associated with several autoimmune diseases. However, the function of CARD9S12N has remained unknown. Here we generated CARD9S12N knock-in mice and found that CARD9S12N facilitated the induction of type 2 immune responses after engagement of CLRs...
May 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#7
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29773091/inactivated-sendai-virus-induces-ros-dependent-apoptosis-and-autophagy-in-human-prostate-cancer-cells
#8
Miao Qian, Hai Ming Tan, Ning Yu, Tao Wang, Quan Zhang
OBJECTIVE: The current study aims to investigate the effect of Hemagglutinating virus of Japan envelope (HVJ-E) on induction of apoptosis and autophagy in human prostate cancer PC3 cells, and the underlying mechanisms. METHODS: PC3 cells were treated with HVJ-E at various multiplicity of infection (MOI), and the generated reactive oxygen species (ROS), cell viability, apoptosis, and autophagy were detected, respectively. Next, the role of ROS played in the regulation of HVJ-E-induced apoptosis and autuphagy in PC3 cells were analysed...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772328/current-evidence-on-management-of-aortic-stent-graft-infection-a-systematic-review-and-meta-analysis
#9
REVIEW
Hai Lei Li, Yiu Che Chan, Stephen W Cheng
OBJECTIVE: Aortic stent-graft infection is rare, but remains one of the most challenging and threatening complications. This systematic review aimed to identify the clinical features, treatment and outcomes of endograft infection after abdominal endovascular aortic repair (EVAR) and thoracic endovascular aortic repair (TEVAR). METHODS: A systematic literature review of all published literature from January 1991 to September 2016 on stent-graft infection was performed under the instruction of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29768330/risk-factors-for-osteoporosis-in-liver-cirrhosis-patients-measured-by-transient-elastography
#10
Jian-Ping Zheng, Hai-Xiong Miao, Shao-Wei Zheng, Wei-le Liu, Chu-Qun Chen, Hao-Bo Zhong, Sheng-Fa Li, Yong-Ping Fang, Chun-Han Sun
Osteoporosis or osteopenia is a common complication in patients with cirrhosis, but little is known about the risk factors for the occurrence of osteoporosis.Patients with liver cirrhosis due to chronic virus infection and alcoholic abuse were enrolled. Bone mineral density (BMD) was determined using dual-energy x-ray absorptiometry (DXA). Osteoporosis was diagnosed according to WHO criteria. The severity of liver stiffness was measured by Fibroscan. Demographic data, such as age, gender, weight, height, and body mass index (BMI), were collected...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29763725/salmonella-infection-may-alter-the-expression-of-toll-like-receptor-4-and-immune-related-cells-in-chicken-bursa-of-fabricius
#11
Abdur Rahman Ansari, Muhammad Arshad, Saima Masood, Hai-Bo Huang, Xing Zhao, Ningya Li, Zhijian Sun, Lei Cui, Yafang Hu, Hua-Zhen Liu
Toll like receptor 4 (TLR4), eosinophils and mast cells play significant role in host immunity during several pathogenic infections. However in vivo tissue expression of TLR4 and distribution pattern of eosinophils and mast cells in chicken bursa of Fabricius (BF) during Salmonella enterica serovar Typhimurium (STm) infection is poorly studied. Therefore, herein, following immunostaining, we found localization of TLR4 in follicular cortex and medulla and its expression was statistical increased after 36h and 72h of STm stimulation...
May 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29754431/expanding-severe-acute-respiratory-infection-sari-surveillance-beyond-influenza-the-process-and-data-from-1-year-of-implementation-in-vietnam
#12
Karen A Alroy, Trang Thuy Do, Phu Dac Tran, Tan Quang Dang, Long Ngoc Vu, Nga Thi Hang Le, Anh Duc Dang, Nghia Duy Ngu, Tu Huy Ngo, Phuong Mai Vu Hoang, Lan Trong Phan, Thuong Vu Nguyen, Long Thanh Nguyen, Thinh Viet Nguyen, Mai Quang Vien, Huy Xuan Le, Anh The Dao, Trieu Bao Nguyen, Duoc Tho Pham, Van Thi Tuyet Nguyen, Thanh Ngoc Pham, Binh Hai Phan, Brett Whitaker, Thuy Thi Thu Do, Phuong Anh Dao, S Arunmozhi Balajee, Anthony W Mounts
BACKGROUND: In 2016, as a component of the Global Health Security Agenda, the Vietnam Ministry of Health expanded its existing influenza sentinel surveillance for severe acute respiratory infections (SARI) to include testing for 7 additional viral respiratory pathogens. This article describes the steps taken to implement expanded SARI surveillance in Vietnam and reports data from 1 year of expanded surveillance. METHOD: The process of expanding the suite of pathogens for routine testing by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) included laboratory trainings, procurement/distribution of reagents, and strengthening and aligning SARI surveillance epidemiology practices at sentinel sites and regional institutes (RI)...
May 13, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29753621/analysis-of-hospital-infection-register-indicates-that-the-implementation-of-who-surgical-safety-checklist-has-an-impact-on-early-postoperative-neurosurgical-infections
#13
Marjut Westman, Harri Marttila, Melissa Rahi, Esa Rintala, Eliisa Löyttyniemi, Tuija Ikonen
WHO surgical safety checklist has been proven to reduce postoperative infections in several studies. The aim of our study was to focus on surgical site infections (SSIs) after neurosurgical operations, and to determine whether the checklist implementation would have an impact on the reported SSIs. We used hospital-acquired infection (HAI) register to evaluate the effects of WHO surgical safety checklist in neurosurgery. The HAI register was searched for superficial and deep SSIs, deep organ SSIs, infections following orthopaedic implantation, and other surgical infections of 4678 neurosurgical patients operated on between 2007 and 2011...
May 9, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29753498/a-multimodal-intervention-to-improve-hand-hygiene-compliance-in-a-tertiary-care-center
#14
Abdul Mannan Laskar, Deepashree R, Prasanna Bhat, Biju Pottakkat, Sunil Narayan, Apurba Sankar Sastry, R Sneha
BACKGROUND: Healthcare-associated infections (HAIs) are a major threat to patient safety worldwide. HAIs are mainly transmitted via the hands of healthcare workers (HCWs), and HCW compliance with hand hygiene (HH) practices is reportedly low. Therefore, multimodal interventions are needed to develop effective HH improvement strategies. In this study, we assessed the effect of multimodal interventions on improvement of HH compliance. METHODS: This study was conducted in 2 intensive care units from August 2016 to October 2016...
May 9, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29740250/ilizarov-method-in-combination-with-autologous-mesenchymal-stem-cells-from-iliac-crest-shows-improved-outcome-in-tibial-non-union
#15
Hui Zhang, Feng Xue, Hai Jun Xiao
Autologous bone grafting and ilizarov technique are the preferred mode of treatment for bone nonunion, studies suggest that bone marrow derived mesenchymal stem cells can be effective in treatment of tibial non-union where there is length of bone defect. The current study investigates the beneficial clinical outcome of combining the ilizarov procedure with intraosseous injection of autologous mesenchymal stem cells. The open-label study enrolled 25 patients with infected tibial non-union at the Shanghai Fengxian District Central Hospital, Shanghai, China between April 2010 and July 2014...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29735821/changing-panorama-for-surveillance-of-device-associated-healthcare-infections-challenges-faced-in-implementation-of-current-guidelines
#16
REVIEW
Renu Gupta, Sangeeta Sharma, Sonal Saxena
Healthcare-associated infections (HAI) are preventable in up to 30% of patients with evidence-based infection prevention and control (IPC) activities. IPC activities require effective surveillance to generate data for the HAI rates, defining priority areas, identifying processes amenable for improvement and institute interventions to improve patient's safety. However, uniform, accurate and standardised surveillance methodology using objective definitions can only generate meaningful data for effective execution of IPC activities...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29734701/complete-nucleotide-sequence-analysis-of-a-novel-bacillus-subtilis-infecting-bacteriophage-bsp10-and-its-effect-on-poly-gamma-glutamic-acid-degradation
#17
Kuntal Ghosh, Amal Senevirathne, Hai Seong Kang, Woo Bin Hyun, Ji Eun Kim, Kwang-Pyo Kim
While the harmful effects of lactic acid bacterial bacteriophages in the dairy industry are well-established, the importance of Bacillus subtilis -infecting bacteriophages on soybean fermentation is poorly-studied. In this study, we isolated a B. subtilis -infecting bacteriophage BSP10 from Meju (a brick of dried fermented soybean) and further characterized it. This Myoviridae family bacteriophage exhibited a narrow host range against B. subtilis strains (17/52, 32.7%). The genome of bacteriophage BSP10 is 153,767 bp long with 236 open reading frames and 5 tRNAs...
May 4, 2018: Viruses
https://www.readbyqxmd.com/read/29730140/multi-centre-point-prevalence-survey-of-hospital-acquired-infections-in-ghana
#18
Appiah-Korang Labi, Noah Obeng-Nkrumah, Enid Owusu, Stephanie Bjerrum, Antoinette Bediako-Bowan, Gifty Sunkwa-Mills, Christiana Akuffo, Ama Pokua Fenny, Japheth Awuletey Opintan, Christabel Enweronu-Laryea, Samuel Debrah, Nelson Damale, Cynthia Bannerman, Mercy Jemima Newman
BACKGROUND: There is a paucity of data describing hospital acquired infections (HAIs) in Africa. OBJECTIVE: To describe the prevalence and distribution of HAIs in acute care hospitals in Ghana. METHODS: Between September and December 2016, point prevalence surveys were conducted in participating hospitals using protocols of the European Centre for Disease Prevention and Control. We reviewed medical records of eligible inpatients at or before 8am on the day of survey to identify HAIs present at the time of survey...
May 3, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29729832/reducing-environmental-surface-contamination-in-healthcare-settings-a-statewide-collaborative
#19
Shari L Solomon, Joan D Plisko, Sara M Wittig, Lindsay V Edwards, Robert H Imhoff, Bonnie DiPietro, Marc J Plisko
To help reduce healthcare-associated infection (HAI) rates across the state, the Maryland Patient Safety Center's Clean Collaborative (Collaborative) supported 17 acute care hospitals, 3 long-term care facilities, and 4 ambulatory surgical centers in improving environmental surface cleaning, with the goal of reducing rates of Clostridium difficile infection, which the Collaborative team selected as a proxy for HAIs. Eighty-eight percent of participating facilities achieved the program goal of a 10% reduction in relative light units from the baseline month to the final month of the Collaborative...
May 2, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29724508/porcine-reproductive-and-respiratory-syndrome-virus-expressing-e2-of-classical-swine-fever-virus-protects-pigs-from-a-lethal-challenge-of-highly-pathogenic-prrsv-and-csfv
#20
Fei Gao, Yifeng Jiang, Guoxin Li, Yanjun Zhou, Lingxue Yu, Liwei Li, Wu Tong, Hao Zheng, Yujiao Zhang, Hai Yu, Tongling Shan, Shen Yang, Huan Liu, Kuan Zhao, Guangzhi Tong
Porcine reproductive and respiratory syndrome (PRRS) and classical swine fever (CSF) are economically significant diseases that affect the swine industry worldwide. However, the current vaccination strategy, which uses two single live attenuated vaccines, can result in interference for each other. In addition, the universally used CSFV vaccine C-strain does not allow for differentiation of infected and vaccinated animals. In this study, rPRRSV-E2, PRRS virus (PRRSV) expressing CSF virus (CSFV) E2, was constructed by reverse genetics...
April 30, 2018: Vaccine
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