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https://www.readbyqxmd.com/read/27908830/protective-efficacy-of-fc-targeting-conserved-influenza-virus-m2e-antigen-expressed-by-lactobacillus-plantarum
#1
Wen-Tao Yang, Gui-Lian Yang, Qian Wang, Hai-Bin Huang, Yan-Long Jiang, Chun-Wei Shi, Jian-Zhong Wang, Ke-Yan Huang, Yu-Bei Jin, Chun-Feng Wang
The influenza A (H1N1) virus is a highly contagious acute respiratory disease affecting pigs and humans. This disease causes severe economic loss in many countries, and developing mucosal vaccines is an efficient strategy to control the influenza virus. The neonatal Fc receptor (FcRn) plays an important role in transferring IgG across polarized epithelial cells. In the present study, an oral vaccine was developed using Lactobacillus plantarum to deliver the internal influenza viral protein M2e fused to an IgG Fc fragment...
November 28, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27907216/correction-deciphering-transcriptome-and-complex-alternative-splicing-transcripts-in-mammary-gland-tissues-from-cows-naturally-infected-with-staphylococcus-aureus-mastitis
#2
Xiu Ge Wang, Zhi Hua Ju, Ming Hai Hou, Qiang Jiang, Chun Hong Yang, Yan Zhang, Yan Sun, Rong Ling Li, Chang Fa Wang, Ji Feng Zhong, Jin Ming Huang
[This corrects the article DOI: 10.1371/journal.pone.0159719.].
2016: PloS One
https://www.readbyqxmd.com/read/27904045/puerarin-prevents-lps-induced-osteoclast-formation-and-bone-loss-via-inhibition-of-akt-activation
#3
Yun Zhang, Ming Yan, Qing-Feng Yu, Pei-Fan Yang, Hai-Dong Zhang, Yong-Hong Sun, Zhi-Fen Zhang, Yun-Feng Gao
Osteolysis induced by chronic Gram-negative bacterial infection underlies many bone diseases such as osteomyelitis, septic arthritis, and periodontitis. Drugs that inhibit lipopolysaccharide (LPS)-induced osteolysis are critically needed for the prevention of bone destruction in infective bone diseases. In this study, we assessed the effect of puerarin, a natural isoflavone isolated from Pueraria lobata OHWI root, on LPS-induced osteoclastogenesis and bone loss. Our in vitro study showed that puerarin significantly inhibited LPS-induced osteoclast differentiation from osteoclast precursor RAW264...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27903067/predicting-the-spatial-distribution-of-biomphalaria-straminea-a-potential-intermediate-host-for-schistosoma-mansoni-in-china
#4
Mohamed R Habib, Yun-Hai Guo, Shan Lv, Wen-Biao Gu, Xiao-Heng Li, Xiao-Nong Zhou
Schistosomiasis is one of the most prevalent parasitic diseases impacting human health in the tropics and sub-tropics. The geographic distribution of Schistosoma mansoni, the most widespread species, includes areas in Africa, the Middle East, South America and the Caribbean. Snails of the genus Biomphalaria act as intermediate host for S. mansoni. Biomphalaria straminea is not indigenous in China but was accidentally introduced to Hong Kong from South America and has spread to other habitats in the southern parts of the country...
November 29, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27902398/clonal-spread-and-accumulation-of-beta-lactams-resistance-determinants-in-enterobacter-aerogenes-and-enterobacter-cloacae-complex-isolates-from-infection-and-colonization-in-patients-at-a-public-hospital-in-recife-pernambuco-brazil
#5
Adriane Borges Cabral, Maria Amélia Vieira Maciel, Josineide Ferreira Barros, Marcelo Maranhão Antunes, Célia Maria Machado Barbosa de Castro, Ana Catarina Souza Lopes
Enterobacter aerogenes and Enterobacter cloacae complex are the species of this genus most involved in healthcare-associated infections (HAIs), that are ESBL and carbapenemase producers. This study has characterized phenotypically and genotypically 51 isolates of E. aerogenes and E. cloacae complex as originated from infection or colonization in patients admitted to public hospital in Recife, Pernambuco, Brazil, by antimicrobial susceptibility profile, analysis of β-lactamase genes (blaTEM, blaSHV, blaCTX-M, blaKPC, blaVIM, blaIMP and blaSPM), PCR and DNA sequencing, plasmid profile and ERIC-PCR...
November 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902392/microbiological-sentinel-events-at-neurological-hospital-a-retrospective-cohort-study
#6
Annalia Asti, Elio Marmondi, Carmine Tinelli, Marta Corbella, Annalisa de Silvestri, Gaetano Bernardi, Franco Andreini, Anna Preti, Monica Bricchi
AbstractThe purpose of this study is to describe the epidemiological surveillance of microbiological sentinel events (SE) carried out between 2012-2014 at the Neurological Hospital Carlo Besta, Milano, Italy. The Setting is inpatient care with Multi- Drug-Resistance infections. The aim of the procedure is to formalize the management mode, the reporting and transmission of SE. Categorical variables were described by counts and percentages, those quantitatives as mean and standard deviation or median and interquartile range...
October 20, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27895356/the-power-peripherally-inserted-central-catheter-is-superior-to-a-central-venous-catheter-in-management-of-patients-with-esophageal-variceal-bleeding-undergoing-devascularization
#7
Wen Jing, He Rong, Jiang Li, Zhang Hai Xia, Zhang Hong Yu, Zhang Ke
Peripherally-inserted central catheters (PICC) have a greater retention time and less complications compared to central venous catheters (CVC). The study was conducted from From January of 2014 to December 2015 at Beijing DiTan Hospital, Beijing, China, and comprised 70 patients undergoing devascularisation. Of the total, 36(51.4%) patients underwent placement of PICC (Group A), while 34(48.6%) underwent had CVC (Group B). Venous catheterisation was successful in all patients. The median duration of venous catheterization in Group A was greater than that in Group B (p=0...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27894256/burkholderia-pseudomallei-derived-mir-3473-enhances-nf-%C3%AE%C2%BAb-via-targeting-traf3-and-is-associated-with-different-inflammatory-responses-compared-to-burkholderia-thailandensis-in-murine-macrophages
#8
Yao Fang, Hai Chen, Yi Hu, Qian Li, Zhiqiang Hu, Tengfei Ma, Xuhu Mao
BACKGROUND: Burkholderia pseudomallei (Bp) is the causative agent of melioidosis, a kind of tropical disease. Burkholderia thailandensis (Bt), with a high sequence similarity to Bp, is thought to be an avirulent organism. Since there are numerous similarities between Bp and Bt, their differences in pathogenesis of host response and related mechanism are still undermined. In recent years, microRNAs have been researched in many diseases, but seldom involved in bacterial infection, bacteria-host interaction or explaining the differences between virulent and avirulent species...
November 28, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27890916/polydatin-ameliorates-staphylococcus-aureus-induced-mastitis-in-mice-via-inhibiting-tlr2-mediated-activation-of-the-p38-mapk-nf-%C3%AE%C2%BAb-pathway
#9
Kang-Feng Jiang, Gan Zhao, Gan-Zhen Deng, Hai-Chong Wu, Nan-Nan Yin, Xiu-Ying Chen, Chang-Wei Qiu, Xiu-Li Peng
Recent studies show that Polydatin (PD) extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. In this study, we investigated the anti-inflammatory effects of PD on Staphylococcus aureus-induced mastitis in mice and elucidated the potential mechanisms. In mice with S aureus-induced mastitis, administration of PD (15, 30, 45 mg/kg, ip) or dexamethasone (Dex, 5 mg/kg, ip) significantly suppressed the infiltration of inflammatory cells, ameliorated the mammary structural damage, and inhibited the activity of myeloperoxidase, a biomarker of neutrophils accumulation...
November 28, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27887623/generation-of-protective-immunity-against-orientia-tsutsugamushi-infection-by-immunization-with-a-zinc-oxide-nanoparticle-combined-with-scaa-antigen
#10
Na-Young Ha, Hyun Mu Shin, Prashant Sharma, Hyun Ah Cho, Chan-Ki Min, Hong-Il Kim, Nguyen Thi Hai Yen, Jae-Seung Kang, Ik-Sang Kim, Myung-Sik Choi, Young Keun Kim, Nam-Hyuk Cho
BACKGROUND: Zinc oxide nanoparticle (ZNP) has been applied in various biomedical fields. Here, we investigated the usage of ZNP as an antigen carrier for vaccine development by combining a high affinity peptide to ZNP. RESULTS: A novel zinc oxide-binding peptide (ZBP), FPYPGGDA, with high affinity to ZNP (K a  = 2.26 × 10(6) M(-1)) was isolated from a random peptide library and fused with a bacterial antigen, ScaA of Orientia tsutsugamushi, the causative agent of scrub typhus...
November 26, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27886039/use-of-personal-digital-assistants-to-detect-healthcare-associated-infections-in-a-neonatal-intensive-care-unit-in-egypt
#11
Elham Am El-Feky, Doa'a A Saleh, Jehan El-Kholy, Ahmed Mahmoud Sayed, Yasmeen Mansi, Mohamed Hashem
INTRODUCTION: Personal digital assistants (PDAs) used in electronic laboratory-based surveillance are a promising alternative to conventional surveillance to detect healthcare-associated infections (HAIs). The aim of the study was to monitor, detect, and analyze HAIs using PDAs in a neonatal intensive care unit (NICU). METHODOLOGY: In this descriptive study, 1,053 neonates admitted to the NICU in the obstetrics and gynecology ward at the Cairo University hospital were included and evaluated for HAIs by collecting data using PDAs programmed by Naval Medical Research Unit 3, Cairo, with the definitions for HAIs provided by the National Healthcare Safety Network of the Centers for Disease Control and Prevention...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27886037/hospital-acquired-infection-in-public-hospital-buildings-in-the-philippines-is-the-type-of-ventilation-increasing-the-risk
#12
Godofreda Ruiz Vergeire-Dalmacion, Jill Rafols Itable, Emmanuel Saporna Baja
INTRODUCTION: Hospital-acquired infections (HAIs) are associated with increased morbidity and mortality, especially in developing countries. However, limited information is available about the risk of HAIs in naturally ventilated wards (NVWs) and mechanically ventilated intensive care units (MVICUs) of public hospitals in the Philippines. We aimed to assess the association between HAIs and type of ventilation in an urban tertiary care hospital in the Philippines. METHODOLOGY: A cross-sectional point-prevalence survey of infections was done in NVWs and MVICUs of a tertiary care hospital in December 2013...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27885561/outbreak-of-severe-pseudorabies-virus-infection-in-pig-offal-fed-farmed-mink-in-liaoning-province-china
#13
Hao Liu, Xin-Tong Li, Bo Hu, Xiao-Yu Deng, Lei Zhang, Shi-Zhen Lian, Hai-Ling Zhang, Shuang Lv, Xiang-Hong Xue, Rong-Guang Lu, Ning Shi, Ming-Hao Yan, Peng-Peng Xiao, Xi-Jun Yan
An outbreak of severe pseudorabies virus (PRV) infection in farmed mink occurred in northern China in late 2014, causing significant economic losses in the local fur industry. Here, we report the first case of a PRV outbreak in mink in northeastern China, caused by feeding farmed mink with raw pork or organs contaminated by PRV. Mink infected with virulent PRV exhibited diarrhea, neurologic signs, and higher mortality, which can be misdiagnosed as highly pathogenic mink enteritis virus (MEV), canine distemper virus (CDV), and food poisoning...
November 24, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27884772/ovol2-gene-inhibits-the-epithelial-to-mesenchymal-transition-in-lung-adenocarcinoma-by-transcriptionally-repressing-twist1
#14
Zhi-Hai Wang, Zhong Li, Meng Hu, Qing-Jie Yang, Shen Yan, Rong-Si Wu, Bo-An Li, Ming Guo
BACKGROUND: Associated with recent achievements in therapy for advanced lung adenocarcinoma, there will still be an unmet medical need for effective treatment of stage IIIb/IV, and the prognosis of lung cancer is not optimistic till now. OBJECTIVE: In order to obtain some essential evidences for a potential targeted therapy in lung adenocarcinoma, the effects of Ovol2 gene on Epithelial-to-Mesenchymal Transition (EMT) was observed and the probable mechanisms were analyzed...
November 21, 2016: Gene
https://www.readbyqxmd.com/read/27884325/violet-405-nm-light-a-novel-therapeutic-agent-against-common-pathogenic-bacteria
#15
Mitchell D Barneck, Nathaniel L R Rhodes, Martin de la Presa, James P Allen, Ahrash E Poursaid, Maziar M Nourian, Matthew A Firpo, John T Langell
BACKGROUND: The increasing incidence of healthcare-associated infections (HAIs) and multidrug-resistant organisms demonstrate the need for innovative technological solutions. Staphylococcus aureus, Streptococcus pneumonia, Escherichia coli, and Pseudomonas aeruginosa in particular are common pathogens responsible for a large percentage of indwelling medical device-associated clinical infections. The bactericidal effects of visible light sterilization (VLS) using 405-nm is one potential therapeutic under investigation...
December 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27883412/prolonged-hospitalization-of-patients-with-hospital-acquired-pneumoniae-in-the-intensive-care-unit-%C3%A2-morbidity-mortality-and-costs-of
#16
Anna Różańska, Marta Wałaszek, Zdzisław Wolak, Małgorzata Bulanda
BACKGROUND: The objective of this study was to determine epidemiological rates of hospital-acquired pneumonia (HAP) in the Polish ICU and direct costs associated with excess length of stay incurred by the hospital. MATERIAL AND METHODS: The studied data concern patients hospitalized in the years 2010–2012 in a 9-bed ICU of a multi-profile hospital in the Małopolskie Province. Centers for Disease Control and Prevention diagnostic criteria were the basis for the development of definitions of infections...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27881987/microscopic-and-molecular-characterization-of-the-prehaustorial-resistance-against-wheat-leaf-rust-puccinia-triticina-in-einkorn-triticum-monococcum
#17
Albrecht Serfling, Sven E Templer, Peter Winter, Frank Ordon
Puccinia triticina f. sp. tritici (Eriks.), the causal agent of leaf rust, causes substantial yield losses in wheat production. In wheat many major leaf rust resistance genes have been overcome by virulent races. In contrast, the prehaustorial resistance (phr) against wheat leaf rust detected in the diploid wheat Einkorn (Triticum monoccocum var. monococcum) accession PI272560 confers race-independent resistance against isolates virulent on accessions harboring resistance genes located on the A-genome of Triticum aestivum...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27876075/chlorhexidine-bathing-and-health-care-associated-infections-among-adult-intensive-care-patients-a-systematic-review-and-meta-analysis
#18
Steven A Frost, Mari-Cris Alogso, Lauren Metcalfe, Joan M Lynch, Leanne Hunt, Ritesh Sanghavi, Evan Alexandrou, Kenneth M Hillman
BACKGROUND: Health care-associated infections (HAI) have been shown to increase length of stay, the cost of care, and rates of hospital deaths (Kaye and Marchaim, J Am Geriatr Soc 62(2):306-11, 2014; Roberts and Scott, Med Care 48(11):1026-35, 2010; Warren and Quadir, Crit Care Med 34(8):2084-9, 2006; Zimlichman and Henderson, JAMA Intern Med 173(22):2039-46, 2013). Importantly, infections acquired during a hospital stay have been shown to be preventable (Loveday and Wilson, J Hosp Infect 86:S1-70, 2014)...
November 23, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27875320/association-of-chronic-hepatitis-b-virus-infection-with-preterm-birth-our-experience-and-meta-analysis
#19
Ai-Min Cui, Jian-Guo Shao, Hai-Bo Li, Yi Shen, Zhi-Xian Chen, Sheng Zhang, Zhao-Lian Bian, Gang Qin, Xiao-Yan Cheng
OBJECTIVES: To assess the association of chronic hepatitis B virus (HBV) infection with preterm birth (PTB). METHODS: A cohort of 20,498 pregnant women (497 HBV carriers with 20,001 non-HBV controls) with normal alanine aminotransferase (ALT) levels was selected from the Obstetrics & Gynecology Hospital of Nantong University. The clinical parameters and PTB incidence were compared between HBV carriers and non-HBV subjects. For the meta-analysis, we searched the PubMed, Ovid and Cochrane Library databases for studies comparing PTB incidence between individuals with chronic HBV infection and non-HBV subjects...
November 22, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27871873/itraq-based-proteomic-analysis-of-defence-responses-triggered-by-the-necrotrophic-pathogen-rhizoctonia-solani-in-cotton
#20
Min Zhang, Shou-Ting Cheng, Hai-Yun Wang, Jia-He Wu, Yuan-Ming Luo, Qian Wang, Fu-Xin Wang, Gui-Xian Xia
: The soil-borne necrotrophic pathogen fungus Rhizoctonia solani is destructive, causing disease in various important crops. To date, little is known about the host defence mechanism in response to invasion of R. solani. Here, an iTRAQ-based proteomic analysis was employed to investigate pathogen-responsive proteins in the disease tolerant/resistant cotton cultivar CRI35. A total of 174 differentially accumulated proteins (DAPs) were identified after inoculation of cotton plants with R...
November 15, 2016: Journal of Proteomics
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