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https://www.readbyqxmd.com/read/28811901/perioperative-safety-analysis-of-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma-patients-with-preprocedural-leukopenia-or-thrombocytopenia
#1
Lin Zhou, Lin-Zhi Zhang, Jing-Yan Wang, Yong-Wu Li, Hai-Dong Hu, Xiao-Ming Peng, Yun Zhao, Xi-Ming Wang, Hui Xie, Chun-Zi Liu, Hua-Ming Wang
Patients with hepatocellular carcinoma (HCC) exhibit a high incidence of concomitant cirrhosis with leukopenia and/or thrombocytopenia. In the present study, perioperative changes in the white blood cell (WBC) and platelet (PLT) counts and associated complications were investigated to assess the safety of transcatheter arterial chemoembolization (TACE) for HCC patients with preprocedural leukopenia or thrombocytopenia. The records of 1,461 HCC patients who received TACE between January 2012 and December 2013 were retrospectively reviewed...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28807835/the-role-of-antimicrobial-stewardship-programmes-in-children-a-systematic-review
#2
REVIEW
André Ricardo Araujo da Silva, Déborah Cardoso Albernaz de Almeida Dias, Amanda Fáris Marques, Clara Biscaia di Biase, Indah K Murni, Angela Dramowski, Mike Sharland, Johanes Huebner, Walter Zingg
The United Nations and the World Health Organization have designated antimicrobial resistance (AMR) as a major health priority and developed action plans to reduce AMR in all healthcare settings. Establishment of institutional antimicrobial stewardship programmes (ASPs) is advocated as a key intervention to reduce antibiotic consumption in hospitals and address high rates of multi-drug resistant (MDR) bacteria. We searched PUBMED and the Cochrane database of systematic reviews (1/2007-3/2017) to identify studies reporting about the effectiveness of ASPs in general paediatric wards and paediatric intensive care units (PICU), on reducing antibiotic consumption, on using broad spectrum/restricted antibiotics, and on antibiotic resistance and healthcare-associated infections (HAIs)...
August 11, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28807607/plasma-cell-and-serum-antibody-responses-to-influenza-vaccine-in-preterm-and-full-term-infants
#3
Carl T D'Angio, Claire P Wyman, Ravi S Misra, Jessica L Halliley, Hongyue Wang, Julianne E Hunn, Caitlin M Fallone, F Eun-Hyung Lee
BACKGROUND: Preterm (PT) infants are at greater risk for severe influenza infection and experience decrements in long-term antibody responses to vaccines. This may related to defects in antibody secreting cell (ASC) generation. OBJECTIVE: To investigate the relationships among the frequencies of influenza-specific antibody secreting cells, ASC numbers and subsets, and antibody responses to influenza vaccines (IV) among PT and full-term (FT) infants. DESIGN/METHODS: We enrolled 11 former PT (≤32weeks' gestation, ≤1500 g' birth weight) and 11FT infants, 6-17months of age, receiving their first influenza immunizations...
August 11, 2017: Vaccine
https://www.readbyqxmd.com/read/28807424/a-national-collaborative-approach-to-reduce-catheter-associated-urinary-tract-infections-in-nursing-homes-a-qualitative-assessment
#4
Sarah L Krein, Molly Harrod, Sue Collier, Kristina K Davis, Andrew J Rolle, Karen E Fowler, Lona Mody
BACKGROUND: Reducing health care-associated infections (HAIs), such as catheter-associated urinary tract infection (CAUTI), is a critical performance improvement target in nursing homes. The Agency for Healthcare Research and Quality Safety Program for Long-term Care: Health Care-Associated Infections/Catheter-Associated Urinary Tract Infection, a national performance improvement program, was designed to promote implementation of a CAUTI prevention program through state-based or regional collaboratives in more than 500 nursing homes across the United States...
August 11, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28807095/simultaneous-detection-of-13-key-bacterial-respiratory-pathogens-by-combination-of-multiplex-pcr-and-capillary-electrophoresis
#5
Lu Xi Jiang, Hong Yu Ren, Hai Jian Zhou, Si Hong Zhao, Bo Yan Hou, Jian Ping Yan, Tian Qin, Yu Chen
OBJECTIVE: Lower respiratory tract infections continue to pose a significant threat to human health. It is important to accurately and rapidly detect respiratory bacteria. To compensate for the limits of current respiratory bacteria detection methods, we developed a combination of multiplex polymerase chain reaction (PCR) and capillary electrophoresis (MPCE) assay to detect thirteen bacterial pathogens responsible for lower respiratory tract infections, including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Mycoplasma pneumoniae, Legionella spp...
August 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28807005/first-records-of-triatoma-rubrofasciata-de-geer-1773-hemiptera-reduviidae-in-foshan-guangdong-province-southern-china
#6
Qin Liu, Yun-Hai Guo, Yi Zhang, Zheng-Bin Zhou, Liang-Liang Zhang, Dan Zhu, Xiao-Nong Zhou
BACKGROUND: Triatomines, also known as kissing bugs, which are found throughout the world and especially in Latin America, are well known natural vectors that transmit American trypanosomiasis, also called Chagas disease. In China, the presence of two species of Triatoma (Triatoma rubrofasciata and T. sinica) was recorded in the past. Due to the growing population and the increasing risk of the global spread of Chagas disease, triatomines became a potential public health nuisance, and in 2016, we started monitoring triatomine activities in southern China...
August 15, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28805287/nongenetically-modified-lactococcus-lactis-adjuvanted-vaccination-enhanced-innate-immunity-against-helicobacter-pylori
#7
Wei Liu, Zhoulin Tan, Hai Liu, Zhiqin Zeng, Shuanghui Luo, Huimin Yang, Lufeng Zheng, Tao Xi, Yingying Xing
BACKGROUND: Gram-positive enhancer matrix particles (GEM) produced by Lactococcus lactis can enhance vaccine-induced immune response. However, the mechanism under which this adjuvant mounts the efficacy of orally administered vaccines remains unexplored. MATERIALS AND METHODS: We used a prophylactic mice model to investigate the mechanism of GEM-adjuvanted vaccination. Helicobacter pylori urease-specific antibody response was monitored and detected in murine serum by ELISA...
August 14, 2017: Helicobacter
https://www.readbyqxmd.com/read/28803443/solasodine-inhibits-human-colorectal-cancer-cells-via-suppression-of-akt-gsk-3%C3%AE-%C3%AE-catenin-pathway
#8
Yu-Wen Zhuang, Cun-En Wu, Jin-Yong Zhou, Xu Chen, Jian Wu, Shan Jiang, Hai-Yan Peng, Xi Zou, Jia-Yun Liu, Da-Peng Wu, Tao Gong, Ming-Hao Qi, Tian Xue, Shen-Lin Liu, Hui Cai
Solasodine is a main active component isolated from Solanum incanum L, who performs a wide range of functions containing anti-oxidant, anti-infection and neurogenesis promotion. In this study, we explored the influence of solasodine on three types of human colorectal cancer (CRC) cell lines. The consequences displayed that solasodine apparently prohibited CRC cell proliferation dose- and time-dependently and impeded CRC cell motility by downregulating Matrix metalloprotease (MMPs). Besides, solasodine was investigated to fuel caspase-cascade reaction and increase the ratio between Bax and Bcl-2 so as to induce CRC cell apoptosis...
August 13, 2017: Cancer Science
https://www.readbyqxmd.com/read/28800609/the-trypomastigote-small-surface-antigen-tssa-regulates-trypanosoma-cruzi-infectivity-and-differentiation
#9
María de Los Milagros Cámara, Gaspar E Cánepa, Andrés B Lantos, Virginia Balouz, Hai Yu, Xi Chen, Oscar Campetella, Juan Mucci, Carlos A Buscaglia
BACKGROUND: TSSA (Trypomastigote Small Surface Antigen) is an antigenic, adhesion molecule displayed on the surface of Trypanosoma cruzi trypomastigotes. TSSA displays substantial sequence identity to members of the TcMUC gene family, which code for the trypomastigote mucins (tGPI-mucins). In addition, TSSA bears sequence polymorphisms among parasite strains; and two TSSA variants expressed as recombinant molecules (termed TSSA-CL and TSSA-Sy) were shown to exhibit contrasting features in their host cell binding and signaling properties...
August 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28792197/transparent-copper-loaded-chitosan-silica-antibacterial-coatings-with-long-term-efficacy
#10
Debirupa Mitra, Min Li, En-Tang Kang, Koon-Gee Neoh
Bacteria-contaminated inanimate surfaces within hospitals and clinics result in transmission of pathogens via direct or indirect contact, leading to increased risk of healthcare-associated infections (HAI). The use of antibacterial coatings is a potential way of reducing the bacterial burden, but many surfaces like instrument panels and monitors necessitate the coatings to be transparent while being highly antibacterial. In this work, silica nanoparticles (SiO2 NPs) were first grown over a layer of acrylated quaternized chitosan (AQCS) covalently immobilized on commercially available transparent polyvinyl fluoride (PVF) films...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28790779/device-associated-healthcare-associated-infections-da-hai-and-the-caveat-of-multiresistance-in-a-multidisciplinary-intensive-care-unit
#11
Inam Danish Khan, Atoshi Basu, Sheshadri Kiran, Shaleen Trivedi, Priyanka Pandit, Anupam Chattoraj
BACKGROUND: Device-Associated Healthcare-Associated Infections (DA-HAI), including Ventilator-Associated Pneumonia (VAP), Central-Line-Associated Blood Stream Infection (CLABSI), and Catheter-Related Urinary Tract Infection (CAUTI), are considered as principal contributors to healthcare hazard and threat to patient safety as they can cause prolonged hospital stay, sepsis, and mortality in the ICU. The study intends to characterize DA-HAI in a tertiary care multidisciplinary ICU of a teaching hospital in eastern India...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28774865/shifts-in-antimicrobial-consumption-and-infection-rates-before-and-during-a-piperacillin-tazobactam-shortage
#12
S Travis King, Katie E Barber, Jason J Parham, Kayla R Stover
BACKGROUND: Anti-infective shortages represent a growing threat to the optimal management of the infected patient and alter the institutional selective pressure against hospital-acquired infections. The objective of this analysis was to assess the impact that a shortage of piperacillin-tazobactam had on the overall antibacterial use and HAI rates at an academic institution. METHODS: Antimicrobial use and infection data were extracted from TheraDoc Clinical Surveillance Software (Premier, Inc...
July 31, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28774756/implementation-in-the-midst-of-complexity-using-ethnography-to-study-health-care-associated-infection-prevention-and-control
#13
Mary Jo Knobloch, Kevin V Thomas, Erin Patterson, Michele L Zimbric, Jackson Musuuza, Nasia Safdar
BACKGROUND: Contextual factors associated with health care settings make reducing health care-associated infections (HAIs) a complex task. The aim of this article is to highlight how ethnography can assist in understanding contextual factors that support or hinder the implementation of evidence-based practices for reducing HAIs. METHODS: We conducted a review of ethnographic studies specifically related to HAI prevention and control in the last 5 years (2012-2017)...
July 31, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28774366/-association-between-s100b-gene-polymorphisms-and-hand-foot-and-mouth-disease-caused-by-enterovirus-71-infection
#14
Jing Li, Ruo-Bing Shan, Rui-Hai Liu, Ying-Jun Xu, Ni-Yan Qu, Gui-Mei Pan, Na Zhang, Na Yang, Zhen-Zhen Chen, Wen-Xiang Zhang, Zi-Pu Li
OBJECTIVE: To investigate the association between rs9722 polymorphisms in the S100B gene and hand, foot and mouth disease (HFMD) caused by enterovirus 71. METHODS: A total of 124 HFMD children with enterovirus 71 infection were enrolled as subjects, and 56 healthy children were enrolled as control group. The rs9722 polymorphisms in the S100B gene were detected for both groups, and the serum level of S100B protein was measured for 74 HFMD children. RESULTS: The rs9722 locus of the S100B gene had three genotypes, CC, CT, and TT, and the genotype frequencies were in accordance with Hardy-Weinberg equilibrium...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28767422/a-meta-analysis-of-transcriptomic-characterization-revealed-extracellular-matrix-pathway-involved-in-the-h5n1-and-h7n9-infections
#15
Feng Wen, Jinyue Guo, Guangzhi Tong, Dingren Bi, Qi Wang, Xiaomin Liu, Shuaiyong Wang, Tonglin Shan, Wu Tong, Yanjun Zhou, Guoxin Li, Hai Yu
Avian-origin H5N1 and H7N9 influenza A viruses are capable of causing lethal infection in humans, with serious lung pathology and leading to acute respiratory distress syndrome. The contribution of host response associated with the poor prognosis of H5N1 and H7N9 infections remains unclear. The aim of this study was to identify the host factors involved in the high pathogenicity of H5N1 and H7N9 by a systematical meta-analysis. The RNA-seq datasets related to H5N1, H7N9, and H1N1 infections with time series were retrieved from GEO...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28763548/effect-of-oral-methylprednisolone-on-clinical-outcomes-in-patients-with-iga-nephropathy-the-testing-randomized-clinical-trial
#16
RANDOMIZED CONTROLLED TRIAL
Jicheng Lv, Hong Zhang, Muh Geot Wong, Meg J Jardine, Michelle Hladunewich, Vivek Jha, Helen Monaghan, Minghui Zhao, Sean Barbour, Heather Reich, Daniel Cattran, Richard Glassock, Adeera Levin, David Wheeler, Mark Woodward, Laurent Billot, Tak Mao Chan, Zhi-Hong Liu, David W Johnson, Alan Cass, John Feehally, Jürgen Floege, Giuseppe Remuzzi, Yangfeng Wu, Rajiv Agarwal, Hai-Yan Wang, Vlado Perkovic
Importance: Guidelines recommend corticosteroids in patients with IgA nephropathy and persistent proteinuria, but the effects remain uncertain. Objective: To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression. Design, Setting, and Participants: The Therapeutic Evaluation of Steroids in IgA Nephropathy Global (TESTING) study was a multicenter, double-blind, randomized clinical trial designed to recruit 750 participants with IgA nephropathy (proteinuria greater than 1 g/d and estimated glomerular filtration rate [eGFR] of 20 to 120 mL/min/1...
August 1, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28762875/acedwardsiella-tarda-induced-mirnas-in-a-teleost-host-global-profile-and-role-in-bacterial-infection-as-revealed-by-integrative-mirna-mrna-analysis
#17
Yong-Hua Hu, Bao-Cun Zhang, Hai-Zheng Zhou, Xiao-Lu Guan, Li Sun
No abstract text is available yet for this article.
August 1, 2017: Virulence
https://www.readbyqxmd.com/read/28760901/synthetic-porcine-hepcidin-exerts-opposite-roles-in-escherichia-coli-and-salmonella-infections
#18
Dan Liu, Zhen-Shun Gan, Wan Ma, Hai-Tao Xiong, Yun-Qing Li, Yi-Zhen Wang, Hua-Hua Du
Hepcidin, an antimicrobial peptide, was discovered to integrate diverse signals from iron status and infection threat and orchestrate a series of host protective responses. There have been several studies investigating the antimicrobial role of hepcidin but controversial. Here, we aim to examine the role of hepcidin in bacterial adherence and invasion in vitro We found that porcine hepcidin could decrease the amount of extracellular pathogen enterotoxigenic Escherichia coli (ETEC) K88 that adhered to cells by aggregating bacteria...
July 31, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28759568/cannabinoid-receptor-2-63-rr-variant-is-independently-associated-with-severe-necroinflammation-in-hiv-hcv-coinfected-patients
#19
Caterina Sagnelli, Caterina Uberti-Foppa, Hamid Hasson, Giulia Bellini, Carmine Minichini, Stefania Salpietro, Emanuela Messina, Diletta Barbanotti, Marco Merli, Francesca Punzo, Nicola Coppola, Adriano Lazzarin, Evangelista Sagnelli, Francesca Rossi
OBJECTIVE: This is the first study to analyze the impact of the rs35761398 variant of the CNR2 gene leading to the substitution of GLN (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with ARG (R) on the clinical presentation of chronic hepatitis in HIV/HCV coinfected patients. METHODS: Enrolled in this study were 166 consecutive HIV/HCV coinfected patients, naïve for HCV treatment. A pathologist unaware of the patients' condition graded liver fibrosis, necroinflammation (Ishak) and steatosis...
2017: PloS One
https://www.readbyqxmd.com/read/28758756/-current-possibilities-to-influence-surgical-site-infection
#20
F Bělina
Infections associated with surgical procedures, also referred to as surgical site infections (SSIs), are the most common nosocomial infections (HAIs - Health Care-Associated Infections) in surgery departments. Although effectively preventable in most cases, they are still associated with significant morbidity and mortality, prolonged or repeated hospitalizations and increased treatment costs. Therefore, compliance with applicable procedures and guidelines is essential for SSI prevention, which was also shown in numerous EBM studies...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
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