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https://www.readbyqxmd.com/read/28719957/four-human-cases-of-diphyllobothrium-nihonkaiense-eucestoda-diphyllobothriidae-in-china-with-a-brief-review-of-chinese-cases
#1
Yu-Chun Cai, Shao-Hong Chen, Hiroshi Yamasaki, Jia-Xu Chen, Yan Lu, Yong-Nian Zhang, Hao Li, Lin Ai, Hai-Ning Chen
We described 4 human infection cases of zoonotic fish-tapeworm, Diphyllobothrium nihonkaiense, identified with morphological and molecular characters and briefly reviewed Chinese cases in consideration of it as an emerging parasitic disease in China. The scolex and mature and gravid proglottids of some cases were seen, a rosette-shaped uterus was observed in the middle of the mature and gravid proglottids, and the diphyllobothriid eggs were yellowish-brown in color and displayed a small knob or abopercular protuberance on the opposite end of a lid-like opening...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28719795/estimating-the-direct-medical-economic-burden-of-health-care-associated-infections-in-public-tertiary-hospitals-in-hubei-province-china
#2
Hao Li, Xinliang Liu, Dan Cui, Quan Wang, Zongfu Mao, Liang Fang, Furong Zhang, Ping Yang, Huiling Wu, Nili Ren, Jianyun He, Jing Sun
This study estimated the attributable direct medical economic burden of health care-associated infections (HAIs) in China. Data were extracted from hospitals' information systems. Inpatient cases with HAIs and non-HAIs were grouped by the propensity score matching (PSM) method. Attributable hospitalization expenditures and length of hospital stay were measured to estimate the direct medical economic burden of HAIs. STATA 12.0 was used to conduct descriptive analysis, bivariate χ(2) test, paired Z test, PSM ( r = 0...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28719319/phosphoproteome-of-toxoplasma-gondii-infected-host-cells-reveals-specific-cellular-processes-predominating-in-different-phases-of-infection
#3
Cheng He, Ai-Yuan Chen, Hai-Xia Wei, Xiao-Shuang Feng, Hong-Juan Peng
The invasion of Toxoplasma gondii tachyzoites into the host cell results in extensive host cell signaling activation/deactivation that is usually regulated by the phosphorylation/dephosphorylation. To elucidate how T. gondii regulates host cell signal transduction, the comparative phosphoproteome of stable isotope labeling with amino acids in cell culture-labeled human foreskin fibroblast cells was analyzed. The cells were grouped (Light [L], Medium [M], and Heavy [H] groups) based on the labeling isotope weight and were infected with T...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718957/elevated-levels-of-il-22-and-il-17a-producing-t-helper-cells-in-cholangiocarcinomarelated-to-liver-fluke-infection
#4
Si-Biao Su, Jian-Feng Zhang, Fei-Fei Huang, Yu Cen, Hai-Xing Jiang
Cholangiocarcinoma (CCA) associated with liver fluke infection appears to involve inflammatory and immune processes, but whether these involve the proinflammatory cytokine interleukin-17A (IL-17A) and proliferative cytokine interleukin-22 (IL-22) is unclear.We compared levels of IL-22- or IL-17A-producing T helper cells and cytokine levels in 30 CCA patients with long-term liver fluke infection, 40 patients with liver-fluke infection but not CCA and 16 healthy controls. Analyses were performed using immunohistochemistry, flow cytometry, ELISA and RT-PCR...
July 18, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28717517/knowledge-mapping-visualization-analysis-of-the-military-health-and-medicine-papers-published-in-the-web-of-science-over-the-past-10%C3%A2-years
#5
Xuan-Ming Zhang, Xuan Zhang, Xu Luo, Hai-Tao Guo, Li-Qun Zhang, Ji-Wei Guo
BACKGROUND: Military medicine is a research field that seeks to solve the medical problems that occur in modern war conditions based on public medicine theory. METHODS: We explore the main research topics of military health and medical research in the web of science™ core collection (WoSCC) from 2007 to 2016, and the goal of this work is to serve as a reference for orientation and development in military health and medicine. Based on CiteSpace III, a reference co-citation analysis is performed for 7921 papers published in the WoSCC from 2007 to 2016...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28716418/wheat-rop-proteins-modulate-defense-response-through-lignin-metabolism
#6
Qing-Hu Ma, Hai-Hao Zhu, Jia-Qi Han
ROP is a subfamily of small GTP-binding proteins that uniquely exist in plants. It acts as versatile molecular switches that regulate various developmental processes. Some ROP proteins are also reported to affect defense responses, although their exact mechanism is not fully understood. Herein, ROP members in wheat were mined; the functions of three wheat ROP proteins were studied. RT-PCR results showed that the expression of TaRac1 was rapidly and strongly induced after leaf rust infection. TaRac1 interacted with TaCCR in yeast-hybridization assay...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28712104/do-bacteria-isolated-from-icu-patients-eskape-antibiotic-treatment-in-vitro-susceptibility-of-the-enterobacteriaceae-family-to-tigecycline
#7
Katarzyna Talaga-Ćwiertnia, Paweł Krzyściak, Małgorzata Bulanda
BACKGROUND: Enterobacteriaceae are currently causing the majority of healthcare-associated infections (HAI) and simultaneously expressing increasing levels of antibiotic resistance. The purpose of this study is to assess the in vitro sensitivity of MDR strains from the family Enterobacteriaceae to tigecycline in relation to their origin from patients hospitalized in intensive care units (ICUs) and non-ICUs. METHODS: The study involved 156 clinically-significant strains of the Enterobacteriaceae family isolated from patients with cIAIs and/or cSSSIs hospitalized in ICUs and other surgical departments...
July 16, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/28706391/utility-of-a-novel-chromogenic-medium-as-a-screening-method-in-the-detection-of-carbapenemase-producing-enterobacteriaceae
#8
Anusha Chaturvedi, Gunjiganur Shankarappa Banashankari
INTRODUCTION: With the emergence of multidrug resistant Gram-negative bugs, there is an urgent need for rapid detection of these resistant organisms. AIM: This study was performed to assess the utility of a novel chromogenic medium in the detection of carbapenemase producing Enterobacteriaceae from various clinical specimens. MATERIALS AND METHODS: A total of 202 isolates of Enterobacteriaceae, which were resistant to meropenem (10 μg) disc by standard disc diffusion method, were analyzed over a period of 6 months...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28704656/induction-of-inkit-by-viral-infection-negatively-regulates-antiviral-responses-through-inhibiting-phosphorylation-of-p65-and-irf3
#9
Bin Lu, Yujie Ren, Xueqin Sun, Cuijuan Han, Hongyan Wang, Yuxuan Chen, Qianqian Peng, Yongbo Cheng, Xiaoliang Cheng, Qiyun Zhu, Wenxin Li, Hong-Liang Li, Hai-Ning Du, Bo Zhong, Zan Huang
The transcription factors p65 and IRF3 play key roles in the induction of cellular antiviral responses. Phosphorylation of p65 and IRF3 is required for their activity and constitutes a key checkpoint. Here we report that viral infection induced upregulation of INKIT, an inhibitor for NF-κB and IRF3 that restricted innate antiviral responses by blocking phosphorylation of p65 and IRF3. INKIT overexpression inhibited virus-induced phosphorylation of p65 and IRF3 and expression of downstream genes. In contrast, knockdown or knockout of INKIT had the opposite effect: Inkit(-/-) mice produced elevated levels of type I interferons and proinflammatory cytokines and were more resistant to lethal viral infection compared to wild-type...
July 12, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28703129/precise-inhibitory-microcircuit-assembly-of-developmentally-related-neocortical-interneurons-in-clusters
#10
Xin-Jun Zhang, Zhizhong Li, Zhi Han, Khadeejah T Sultan, Kun Huang, Song-Hai Shi
GABA-ergic interneurons provide diverse inhibitions that are essential for the operation of neuronal circuits in the neocortex. However, the mechanisms that control the functional organization of neocortical interneurons remain largely unknown. Here we show that developmental origins influence fine-scale synapse formation and microcircuit assembly of neocortical interneurons. Spatially clustered neocortical interneurons originating from low-titre retrovirus-infected radial glial progenitors in the embryonic medial ganglionic eminence and preoptic area preferentially develop electrical, but not chemical, synapses with each other...
July 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28703004/sialylglycan-assembled-supra-dots-for-ratiometric-probing-and-blocking-of-human-infecting-influenza-viruses
#11
Chang-Zheng Wang, Hai-Hao Han, Xin-Ying Tang, Dong-Ming Zhou, Changfeng Wu, Guo-Rong Chen, Xiao-Peng He, He Tian
The seasonal outbreak of influenza causes significant morbidity and mortality worldwide because a number of influenza virus (IV) strains have been shown to infect and circulate in humans. Development of effective means to timely monitor as well as block IVs is still a challenging task. Whereas conventional fluorescence probes rely on a fluorimetric change upon recognizing IVs, here we developed simple "Supra-dots" that are formed through the aqueous supramolecular assembly between a blue-emitting polymer dot and red-emitting sialylglycan probes for the ratiometric detection of IVs...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28696611/-prevention-of-health-care-associated-infections-and-bacterial-resistance-guidance-for-good-practice
#12
Alain Kenfak Foguena, Alain Cometta, Laurence Senn
Despite improvement of infection control measures during the last 20 years, incidence of health care associated infections (HAI) remains high. HAI, also known as nosocomial infections, are mainly due to susceptible bacteria. However, resistant bacteria are responsible for some of them. In Switzerland, methicillin resistant Staphylococcus aureus incidence is decreasing but enterobacteriaceae producing extended spectrum beta-lactamase are increasing. In addition, emerging resistance challenges such as vancomycin-resistant enterococci or carbapenemase-producing bacteria were observed occasionally during recent years...
November 23, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28694807/brucella-omp25-upregulates-mir-155-mir-21-5p-and-mir-23b-to-inhibit-interleukin-12-production-via-modulation-of-programmed-death-1-signaling-in-human-monocyte-macrophages
#13
Beibei Cui, Wenli Liu, Xiaoya Wang, Yu Chen, Qian Du, Xiaomin Zhao, Hai Zhang, Shan-Lu Liu, Dewen Tong, Yong Huang
Brucella spp. infection results in compromised Type1 (Th1) cellular immune response. Several reports have described an immunomodulatory function for Brucella major outer membrane protein Omp25. However, the mechanism by which Omp25 modulates macrophage dysfunction has not been defined. Herein, we reported that Omp25-deficient mutant of Brucella suis exhibited an enhanced ability to induce interleukin (IL)-12 whereas ectopic expression of Omp25 protein inhibited TLR agonists-induced IL-12 p70 production through suppression of both IL-12 p40 and p35 subunit expression in THP-1 cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28687324/in%C3%A2-vitro-antiviral-efficacy-of-caffeic-acid-against-canine-distemper-virus
#14
Zong-Mei Wu, Zhen-Jiang Yu, Zhen-Qiang Cui, Lu-Yuan Peng, Hao-Ran Li, Chun-Lei Zhang, Hai-Qing Shen, Peng-Fei Yi, Ben-Dong Fu
Canine distemper (CD) is a highly contagious disease caused by the canine distemper virus (CDV), and mortality can be as high as 100%. However, there is no specific treatment for CD. In this study, the antiviral activity of the caffeic acid against CDV was evaluated in vitro. The results showed that the IC50 of the caffeic acid against CDV at 1 and 2 h post infection (PI) is 23.3 and 32.3 μg/mL, respectively. Consistently, at 1 and 2 h PI, the caffeic acid exhibited a reduced (23.3-57.0% and 37.2-38.1%) viral inhibitory effect in vero cells...
July 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28686629/the-characteristics-of-screening-and-confirmatory-test-results-for-hiv-in-xi-an-china
#15
Linchuan Wang, Kai-Hua Zhou, He-Ping Zhao, Ji-Han Wang, Hai-Chao Zheng, Yan Yu, Wei Chen
OBJECTIVES: Individuals with recent or acute HIV infection are more infectious than those with established infection. Our objective was to analyze the characteristics of detection among HIV infections in Xi'an. METHODS: A 4th-generation kit (Architect HIV Ag/Ab Combo) and three 3rd-generationEIA kits (WanTai, XinChuang and Livzon) were used for HIV screening. Overall, 665 individuals were identified as positive and were tested by western blotting (WB). The characteristics of the screening and confirmatory tests were analyzed, including the band patterns, the early detection performance and the false-positive rates...
2017: PloS One
https://www.readbyqxmd.com/read/28684545/macrolides-protect-against-pseudomonas-aeruginosa-infection-via-inhibition-of-inflammasomes
#16
Li-Chao Fan, Jie-Lu Lin, Jia-Wei Yang, Bei Mao, Hai-Wen Lu, Bao-Xue Ge, Augustine M K Choi, Jinfu Xu
Background Macrolides antibiotics have been used effectively in many chronic diseases, especially with Pseudomonas aeruginosa (P. aeruginosa) infection. The mechanisms underlying the therapeutic effects of macrolides in these diseases remain poorly understood. Methods We established a mouse model of chronic lung infection using P. aeruginosa agar-beads, with azithromycin treatment or placebo. Lung injury, bacterial clearance and inflammasome-related proteins were measured. In vitro, the inflammasomes activation induced by flagellin or ATP were assessed in LPS-primed macrophages with or without macrolides treatment...
July 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28682779/in-vitro-and-in-vivo-studies-of-nematophagous-fungi-arthrobotrys-musiformis-and-arthrobotrys-robusta-against-the-larvae-of-the-trichostrongylides
#17
Kui Zheng Cai, Bo Bo Wang, Qiang Xu, Jun Lin Liu, Kang Ying Wang, Yu Jia Xue, Hai Yan Zhang, Hai Yu Wang, Xin Cao, Zhong Ren Ma
Six isolates of Arthrobotrys musiformis and five isolates of Arthrobotrys robusta were assessed in in vitro test regarding the capacity of prey larvae of the natural mixed trichostrongylides. In 5 isolates of A. robusta, the decrease percentage of infective larvae (L3) of trichostrongylides ranged from 97.71%-99.98% and for the isolates of A. musiformis, 5 isolates ranged from 97.99%-99.95% and only NF015 isolate 60.72%. In the following, the isolate (NPS045) of A. musiformis was selected to assess its excretion time in feces after oral administration of goats...
September 26, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28677216/hygiene-microbial-strategies-to-reduce-pathogens-and-drug-resistance-in-clinical-settings
#18
Elisabetta Caselli
Healthcare-associated infections (HAIs) are a global concern, affecting all western hospitals, and profoundly impairing the clinical outcome of up to 15% of all hospitalized patients. Persistent microbial contamination of hospital surfaces has been suggested to contribute to HAIs onset, representing a reservoir for hospital pathogens. On the other hand, conventional chemicals-based sanitation do not prevent recontamination and can select drug-resistant strains, resulting in over 50% of surfaces persistently contaminated...
July 5, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28671914/assessment-of-automating-safety-surveillance-from-electronic-health-records-analysis-for-the-quality-and-safety-review-system
#19
Allan Fong, Katharine Adams, Anita Samarth, Laura McQueen, Manan Trivedi, Tahleah Chappel, Erin Grace, Susan Terrillion, Raj M Ratwani
BACKGROUND AND OBJECTIVES: In an effort to improve and standardize the collection of adverse event data, the Agency for Healthcare Research and Quality is developing and testing a patient safety surveillance system called the Quality and Safety Review System (QSRS). Its current abstraction from medical records is through manual human coders, taking an average of 75 minutes to complete the review and abstraction tasks for one patient record. With many healthcare systems across the country adopting electronic health record (EHR) technology, there is tremendous potential for more efficient abstraction by automatically populating QSRS...
June 30, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28671616/incidence-of-ventilator-associated-pneumonia-in-critically-ill-children-undergoing-mechanical-ventilation-in-pediatric-intensive-care-unit
#20
Ali Amanati, Abdollah Karimi, Alireza Fahimzad, Ahmad Reza Shamshiri, Fatemeh Fallah, Alireza Mahdavi, Mahshid Talebian
BACKGROUND: Among hospital-acquired infections (HAIs) in children, ventilator-associated pneumonia (VAP) is the most common after blood stream infection (BSI). VAP can prolong length of ventilation and hospitalization, increase mortality rate, and directly change a patient's outcome in Pediatric Intensive Care Units (PICU). OBJECTIVES: The research on VAP in children is limited, especially in Iran; therefore, the identification of VAP incidence and mortality rate will be important for both clinical and epidemiological implications...
July 3, 2017: Children
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