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https://www.readbyqxmd.com/read/28592121/inhibition-of-jmjd6-expression-reduces-the-proliferation-migration-and-invasion-of-neuroglioma-stem-cells
#1
D X Zhou, D Zhou, S Q Zhan, P Wang, K Qin, W Gan, X F Lin
Neuroglioma is the most common form of human primary malignant brain tumor, more and more studies recently showed only a small subpopulation of glioma cells which called glioma stem cells have true tumorigenic potential. Meanwhile, it was reported the overexpression of JMJD6 protein is closely involvement with the occurrence and development of multiple tumors, and JMJD6 is required for the differentiation of multiple organ, tissues and cells during embryogenesis. However, the influence of JMJD6 overexpression on neuroglioma development is unclear now...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28587176/bifunctional-enzyme-jmjd6-contributes-to-multiple-disease-pathogenesis-new-twist-on-the-old-story
#2
REVIEW
Shiva Shankar Vangimalla, Murali Ganesan, Kusum K Kharbanda, Natalia A Osna
Jumonji domain-containing protein 6 (JMJD6) is a non-heme Fe(II) 2-oxoglutarate (2OG)-dependent oxygenase with arginine demethylase and lysyl hydroxylase activities. Its initial discovery as a dispensable phosphatidylserine receptor (PSR) in the cell membrane of macrophages for phagocytosis was squashed by newer studies which revealed its nuclear localization and bifunctional enzymatic activity. Though its interaction with several nuclear and cytoplasmic target proteins has been demonstrated, the exact mechanisms and clinical significance of these various biologic interplays are not yet well established...
June 1, 2017: Biomolecules
https://www.readbyqxmd.com/read/28546003/thymic-epithelial-cell-specific-deletion-of-jmjd6-reduces-aire-protein-expression-and-exacerbates-disease-development-in-a-mouse-model-of-autoimmune-diabetes
#3
Toyoshi Yanagihara, Takahiro Tomino, Takehito Uruno, Yoshinori Fukui
Thymic epithelial cells (TECs) establish spatially distinct microenvironments in which developing T cells are selected to mature or die. A unique property of medullary TECs is their expression of thousands of tissue-restricted self-antigens that is largely under the control of the transcriptional regulator Aire. We previously showed that Jmjd6, a lysyl hydroxylase for splicing regulatory proteins, is important for Aire protein expression and that transplantation of Jmjd6-deficient thymic stroma into athymic nude mice resulted in multiorgan autoimmunity...
July 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28364140/insights-into-jumonji-c-domain-containing-protein-6-jmjd6-a-multifactorial-role-in-foot-and-mouth-disease-virus-replication-in-cells
#4
REVIEW
Paul Lawrence, Elizabeth Rieder
The Jumonji C-domain containing protein 6 (JMJD6) has had a convoluted history, and recent reports indicating a multifactorial role in foot-and-mouth disease virus (FMDV) infection have further complicated the functionality of this protein. It was first identified as the phosphatidylserine receptor on the cell surface responsible for recognizing phosphatidylserine on the surface of apoptotic cells resulting in their engulfment by phagocytic cells. Subsequent study revealed a nuclear subcellular localization, where JMJD6 participated in lysine hydroxylation and arginine demethylation of histone proteins and other non-histone proteins...
June 2017: Virus Genes
https://www.readbyqxmd.com/read/28360925/jmjd6-a-jmjc-dioxygenase-with-many-interaction-partners-and-pleiotropic-functions
#5
REVIEW
Janice Kwok, Marie O'Shea, David A Hume, Andreas Lengeling
Lysyl hydroxylation and arginyl demethylation are post-translational events that are important for many cellular processes. The jumonji domain containing protein 6 (JMJD6) has been reported to catalyze both lysyl hydroxylation and arginyl demethylation on diverse protein substrates. It also interacts directly with RNA. This review summarizes knowledge of JMJD6 functions that have emerged in the last 15 years and considers how a single Jumonji C (JmjC) domain-containing enzyme can target so many different substrates...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28351428/erratum-to-jmjd6-is-a-driver-of-cellular-proliferation-and-motility-and-a-marker-of-poor-prognosis-in-breast-cancer
#6
Yi Fang Lee, Lance David Miller, Xiu Bin Chan, Michael A Black, Brendan Pang, Chee Wee Ong, Manuel Salto-Tellez, Edison T Liu, Kartiki V Desai
No abstract text is available yet for this article.
March 28, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27899633/jmjd6-and-u2af65-co-regulate-alternative-splicing-in-both-jmjd6-enzymatic-activity-dependent-and-independent-manner
#7
Jia Yi, Hai-Feng Shen, Jin-Song Qiu, Ming-Feng Huang, Wen-Juan Zhang, Jian-Cheng Ding, Xiao-Yan Zhu, Yu Zhou, Xiang-Dong Fu, Wen Liu
JMJD6, a jumonji C (Jmj C) domain-containing protein demethylase and hydroxylase, has been implicated in an array of biological processes. It has been shown that JMJD6 interacts with and hydroxylates multiple serine/arginine-rich (SR) proteins and SR related proteins, including U2AF65, all of which are known to function in alternative splicing regulation. However, whether JMJD6 is widely involved in alternative splicing and the molecular mechanism underlying JMJD6-regulated alternative splicing have remained incompletely understood...
April 7, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27613418/pcaf-mediated-acetylation-of-transcriptional-factor-hoxb9-suppresses-lung-adenocarcinoma-progression-by-targeting-oncogenic-protein-jmjd6
#8
Junhu Wan, Weizhi Xu, Jun Zhan, Ji Ma, Xueying Li, Yuping Xie, Jiadong Wang, Wei-Guo Zhu, Jianyuan Luo, Hongquan Zhang
HOXB9 is a homeobox domain-containing transcription factor, playing an important role in embryonic development and cancer progression. However, the precise post-translational modifications (PTMs) of HOXB9 and the corresponding roles are unclear. Here, we report that acetyltransferase p300/CBP-associated factor (PCAF) interacts with and acetylates HOXB9 both in vivo and in vitro Conversely, the acetylation of HOXB9 can be reversed by deacetylase SIRT1. Furthermore, we found that HOXB9 is acetylated at lysine 27 (AcK27)...
December 15, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27556302/protein-arginine-methylation-demethylation-and-cancer
#9
REVIEW
Coralie Poulard, Laura Corbo, Muriel Le Romancer
Protein arginine methylation is a common post-translational modification involved in numerous cellular processes including transcription, DNA repair, mRNA splicing and signal transduction. Currently, there are nine known members of the protein arginine methyltransferase (PRMT) family, but only one arginine demethylase has been identified, namely the Jumonji domain-containing 6 (JMJD6). Although its demethylase activity was initially challenged, its dual activity as an arginine demethylase and a lysine hydroxylase is now recognized...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27171244/subsets-of-visceral-adipose-tissue-nuclei-with-distinct-levels-of-5-hydroxymethylcytosine
#10
Ping Yu, Lexiang Ji, Kevin J Lee, Miao Yu, Chuan He, Suresh Ambati, Elizabeth C McKinney, Crystal Jackson, Clifton A Baile, Robert J Schmitz, Richard B Meagher
The reprogramming of cellular memory in specific cell types, and in visceral adipocytes in particular, appears to be a fundamental aspect of obesity and its related negative health outcomes. We explored the hypothesis that adipose tissue contains epigenetically distinct subpopulations of adipocytes that are differentially potentiated to record cellular memories of their environment. Adipocytes are large, fragile, and technically difficult to efficiently isolate and fractionate. We developed fluorescence nuclear cytometry (FNC) and fluorescence activated nuclear sorting (FANS) of cellular nuclei from visceral adipose tissue (VAT) using the levels of the pan-adipocyte protein, peroxisome proliferator-activated receptor gamma-2 (PPARg2), to distinguish classes of PPARg2-Positive (PPARg2-Pos) adipocyte nuclei from PPARg2-Negative (PPARg2-Neg) leukocyte and endothelial cell nuclei...
2016: PloS One
https://www.readbyqxmd.com/read/27081402/the-epigenetic-modifier-jmjd6-is-amplified-in-mammary-tumors-and-cooperates-with-c-myc-to-enhance-cellular-transformation-tumor-progression-and-metastasis
#11
Olga Aprelikova, Kenny Chen, Lara H El Touny, Constance Brignatz-Guittard, Justin Han, Tinghu Qiu, Howard H Yang, Maxwell P Lee, Min Zhu, Jeffrey E Green
BACKGROUND: Oncogene overexpression in primary cells often triggers the induction of a cellular safeguard response promoting senescence or apoptosis. Secondary cooperating genetic events are generally required for oncogene-induced tumorigenesis to overcome these biologic obstacles. We employed comparative genomic hybridization for eight genetically engineered mouse models of mammary cancer to identify loci that might harbor genes that enhance oncogene-induced tumorigenesis. RESULTS: Unlike many other mammary tumor models, the MMTV-Myc tumors displayed few copy number variants except for amplification of distal mouse chromosome 11 in 80 % of the tumors (syntenic to human 17q23-qter often amplified in human breast cancer)...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27071056/global-gene-expression-profiling-of-jmjd6-and-jmjd4-depleted-mouse-nih3t3-fibroblasts
#12
Yu-Jie Hu, Anthony N Imbalzano
Emerging evidence suggests Jumonji domain-containing proteins are epigenetic regulators in diverse biological processes including cellular differentiation and proliferation. RNA interference-based analyses combined with gene expression profiling can effectively characterize the cellular functions of these enzymes. We found that the depletion of Jumonji domain-containing protein 6 (JMJD6) and its paralog protein Jumonji domain-containing protein 4 (JMJD4) individually by small hairpin RNAs (shRNAs) slowed cell proliferation of mouse NIH3T3 fibroblasts...
2016: Scientific Data
https://www.readbyqxmd.com/read/26914509/pathogenesis-and-micro-anatomic-characterization-of-a-cell-adapted-mutant-foot-and-mouth-disease-virus-in-cattle-impact-of-the-jumonji-c-domain-containing-protein-6-jmjd6-and-route-of-inoculation
#13
Paul Lawrence, Juan Pacheco, Carolina Stenfeldt, Jonathan Arzt, Devendra K Rai, Elizabeth Rieder
A companion study reported Jumonji-C domain containing protein 6 (JMJD6) is involved in an integrin- and HS-independent pathway of FMDV infection in CHO cells. JMJD6 localization was investigated in animal tissues from cattle infected with either wild type A24-FMDV (A24-WT) or mutant FMDV (JMJD6-FMDV) carrying E95K/S96L and RGD to KGE mutations in VP1. Additionally, pathogenesis of mutant JMJD6-FMDV was investigated in cattle through aerosol and intraepithelial lingual (IEL) inoculation. Interestingly, JMJD6-FMDV pathogenesis was equivalent to A24-WT administered by IEL route...
May 2016: Virology
https://www.readbyqxmd.com/read/26896934/role-of-jumonji-c-domain-containing-protein-6-jmjd6-in-infectivity-of-foot-and-mouth-disease-virus
#14
Paul Lawrence, Devendra Rai, Joseph S Conderino, Sabena Uddowla, Elizabeth Rieder
Foot-and-mouth disease virus (FMDV) utilizes four integrins (αvβ1, αvβ3, αvβ6, and αvβ8) as its primary cell receptor. During cell culture propagation, FMDV frequently adapts to use heparan sulfate (HS), and rarely utilizes an unidentified third receptor. Capsid mutations acquired by a soluble integrin resistant FMDV cause (i) adaptation to CHO-677 cells (ii) increased affinity to membrane-bound Jumonji C-domain containing protein 6 (JMJD6) (iii) induced JMJD6 re-localization from the cell surface and cytoplasm to the nucleus...
May 2016: Virology
https://www.readbyqxmd.com/read/26819475/jumonji-domain-containing-protein-6-is-decreased-in-human-preeclamptic-placentas-and-regulates-sflt-1-splice-variant-production
#15
Kirsten R Palmer, Stephen Tong, Laura Tuohey, Ping Cannon, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Sebastián E Illanes, Tu'uhevaha J Kaitu'u-Lino
The anti-angiogenic protein, soluble fms-like tyrosine kinase-1 (sFLT-1), plays a central role in preeclamptic pathophysiology. A splice variant of FLT-1 (VEGF receptor 1), sFLT-1 is released in excessive amounts from the preeclamptic placenta into the maternal circulation, where it causes endothelial dysfunction manifesting as end-organ disease. However, the mechanisms regulating its production within the placenta remain poorly understood. Recently it was shown in endothelial cells that Jumonji domain containing protein 6 (JMJD6) hydroxylates U2 small nuclear ribonucleoprotein auxiliary factor 65-kDa subunit (U2AF65, a component of the splicesome)...
March 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/26645717/elevated-expression-of-jmjd6-is-associated-with-oral-carcinogenesis-and-maintains-cancer-stemness-properties
#16
Chang-Ryul Lee, Sung Hee Lee, Nicole Kristina Rigas, Reuben H Kim, Mo K Kang, No-Hee Park, Ki-Hyuk Shin
Cancer stem cells (CSCs) are defined as a small subpopulation of cancer cells within a tumor and responsible for initiation and maintenance of tumor growth. Thus, understanding of molecular regulators of CSCs is of paramount importance for the development of effective cancer therapies. Here, we identified jumonji domain-containing protein 6 (JMJD6) as a novel molecular regulator of oral CSCs. JMJD6 is highly expressed in CSC-enriched populations of human oral squamous cell carcinoma (OSCC) cell lines. Moreover, immunohistochemical staining revealed significantly high level of JMJD6 in OSCC tissues compared to normal human oral epithelia, suggesting that expression of JMJD6 positively correlates with oral carcinogenesis...
February 2016: Carcinogenesis
https://www.readbyqxmd.com/read/26531897/intronic-regulation-of-aire-expression-by-jmjd6-for-self-tolerance-induction-in-the-thymus
#17
Toyoshi Yanagihara, Fumiyuki Sanematsu, Tetsuya Sato, Takehito Uruno, Xuefeng Duan, Takahiro Tomino, Yosuke Harada, Mayuki Watanabe, Yuqing Wang, Yoshihiko Tanaka, Yoichi Nakanishi, Mikita Suyama, Fukui Yoshinori
The thymus has spatially distinct microenvironments, the cortex and the medulla, where the developing T-cells are selected to mature or die through the interaction with thymic stromal cells. To establish the immunological self in the thymus, medullary thymic epithelial cells (mTECs) express diverse sets of tissue-specific self-antigens (TSAs). This ectopic expression of TSAs largely depends on the transcriptional regulator Aire, yet the mechanism controlling Aire expression itself remains unknown. Here, we show that Jmjd6, a dioxygenase that catalyses lysyl hydroxylation of splicing regulatory proteins, is critical for Aire expression...
2015: Nature Communications
https://www.readbyqxmd.com/read/26256758/online-probing-quantum-dots-and-engineered-enzyme-self-assembly-in-a-nanoliter-scale
#18
Jianhao Wang, Jinchen Li, Jianpeng Wang, Cheli Wang, Tiwan Teng, Yao Chen, Jinping Li, Bingyu Dong, Lin Qiu, Pengju Jiang
Nanoparticles provide significantly enhanced binding characteristics. However, fast online probing of the self-assembly process remains hard to achieve in practice. Herein, we report a fluorescence coupled CE method for probing the self-assembly events between quantum dots (QDs) and engineered Jumonji domain-containing protein 6 (Jmjd6) enzyme. QDs and Jmjd6 were sequentially injected into the capillary, where the self-assembly took place in a nanoliter scale. In particular, we showed that the Jmjd6/QD ratio, the interval time, and the injection volume had a great effect on the online self-assembly...
February 2016: Electrophoresis
https://www.readbyqxmd.com/read/26221041/dynamic-arginine-methylation-of-tumor-necrosis-factor-tnf-receptor-associated-factor-6-regulates-toll-like-receptor-signaling
#19
Irina Tikhanovich, Sudhakiranmayi Kuravi, Antonio Artigues, Maria T Villar, Kenneth Dorko, Atta Nawabi, Benjamin Roberts, Steven A Weinman
Arginine methylation is a common post-translational modification, but its role in regulating protein function is poorly understood. This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase involved in innate immune signaling, is regulated by reversible arginine methylation in a range of primary and cultured cells. Under basal conditions, TRAF6 is methylated by the methyltransferase PRMT1, and this inhibits its ubiquitin ligase activity, reducing activation of toll-like receptor signaling...
September 4, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26157142/jmjc-domain-containing-protein-6-jmjd6-derepresses-the-transcriptional-repressor-transcription-factor-7-like-1-tcf7l1-and-is-required-for-body-axis-patterning-during-xenopus-embryogenesis
#20
Xuena Zhang, Yan Gao, Lei Lu, Zan Zhang, Shengchun Gan, Liyang Xu, Anhua Lei, Ying Cao
Tcf7l1 (also known as Tcf3) is a bimodal transcription factor that plays essential roles in embryogenesis and embryonic and adult stem cells. On one hand, Tcf7l1 works as transcriptional repressor via the recruitment of Groucho-related transcriptional corepressors to repress the transcription of Wnt target genes, and, on the other hand, it activates Wnt target genes when Wnt-activated β-catenin interacts with it. However, how its activity is modulated is not well understood. Here we demonstrate that a JmjC-domain containing protein, Jmjd6, interacts with Tcf7l and derepresses Tcf7l...
August 14, 2015: Journal of Biological Chemistry
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