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DNMT3B

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https://www.readbyqxmd.com/read/28192769/disorganization-at-the-stage-of-schizophrenia-clinical-outcome-clinical-biological-study
#1
A Nestsiarovich, V Obyedkov, H Kandratsenka, M Siniauskaya, I Goloenko, N Waszkiewicz
BACKGROUND: According to the multidimensional model of schizophrenia, three basic psychopathological dimensions constitute its clinical structure: positive symptoms, negative symptoms and disorganization. The latter one is the newest and the least studied. Our aim was to discriminate disorganization in schizophrenia clinical picture and to identify its distinctive biological and socio-psychological particularities and associated genetic and environmental factors. METHODS: We used SAPS/SANS psychometrical scales, scales for the assessment of patient's compliance, insight, social functioning, life quality...
December 30, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28177119/downregulation-of-methyltransferase-dnmt2-results-in-condition-dependent-telomere-shortening-and-senescence-or-apoptosis-in-mouse-fibroblasts
#2
Anna Lewinska, Jagoda Adamczyk-Grochala, Ewa Kwasniewicz, Maciej Wnuk
Dnmt2 is a highly conserved methyltransferase of uncertain biological function(s). As Dnmt2 was considered as a driver of fruit fly longevity and a modulator of stress response, we decided to evaluate the role of Dnmt2 during stress-induced premature senescence in NIH3T3 mouse fibroblasts. Stable knockdown of Dnmt2 resulted in hydrogen peroxide-mediated sensitivity and apoptosis, whereas in the control conditions, senescence was induced. Cellular senescence was accompanied by elevated levels of p53 and p21, decreased telomere length and telomerase activity, increased production of reactive oxygen species and protein carbonylation, and DNA damage...
February 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28161170/maternal-supplementation-with-rumen-protected-methionine-increases-prepartal-plasma-methionine-concentration-and-alters-hepatic-mrna-abundance-of-1-carbon-methionine-and-transsulfuration-pathways-in-neonatal-holstein-calves
#3
C B Jacometo, Z Zhou, D Luchini, M N Corrêa, J J Loor
An important mechanism of nutritional "programming" induced by supplementation with methyl donors during pregnancy is the alteration of mRNA abundance in the offspring. We investigated the effects of rumen-protected Met (RPM) on abundance of 17 genes in the 1-carbon, Met, and transsulfuration pathways in calf liver from cows fed the same basal diet without (control, CON) or with RPM at 0.08% of diet dry matter/d (MET) from -21 through +30 d around calving. Biopsies (n = 8 calves per diet) were harvested on d 4, 14, 28, and 50 of age...
February 1, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28160561/an-association-between-overexpression-of-dna-methyltransferase-3b4-and-clear-cell-renal-cell-carcinoma
#4
You Liu, Liantao Sun, Peter Fong, Jie Yang, Zhuxia Zhang, Shuihui Yin, Shuyuan Jiang, Xiaolei Liu, Hongge Ju, Lihua Huang, Jing Bai, Kerui Gong, Shaochun Yan, Chunyang Zhang, Guo Shao
It is well known that abnormal DNA methylations occur frequently in kidney cancer. However, it remains unclear exactly which types of DNA methyltransferases (DNMT) contribute to the pathologies of kidney cancers. In order to determine the functions of DNA methyltransferase in kidney tumorigenesis on the molecular level, we examined the mRNA expression levels of DNMT1, DNMT3A, DNMT3B, and DNMT3B variants in renal cell carcinoma tissue. Both mRNA and protein levels of DNMT3B4, a splice variant of DNMT3B, were increased in renal cell carcinoma tissue compared with adjacent control tissues...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28128455/expanding-the-mutation-spectrum-in-icf-syndrome-evidence-for-a-gender-bias-in-icf2
#5
Marlinde L van Boogaard, Peter E Thijssen, Caner Aytekin, Francesco Licciardi, Ayça A Kıykım, Lucia Spossito, Virgil A S H Dalm, Gertjan J Driessen, Rogier Kersseboom, Femke de Vries, Monique M van Ostaijen-Ten Dam, Aydan Ikinciogullari, Figen Dogu, Matias Oleastro, Edgardo Bailardo, Lucia Daxinger, Ercan Nain, Safa Baris, Maarten J D van Tol, Corry Weemaes, Silvère M van der Maarel
Immunodeficiency, centromere instability and facial anomalies (ICF) syndrome is a rare, genetically heterogeneous, autosomal recessive disorder. Patients suffer from recurrent infections caused by reduced levels or absence of serum immunoglobulins. Genetically, four subtypes of ICF syndrome have been identified to date: ICF1 (DNMT3B mutations), ICF2 (ZBTB24 mutations), ICF3 (CDCA7 mutations) and ICF4 (HELLS mutations). In this study we describe seven ICF1 patients and six novel missense mutations in DNMT3B, affecting highly conserved residues in the catalytic domain...
January 27, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28127428/dna-methyltransferases-and-their-roles-in-tumorigenesis
#6
REVIEW
Wu Zhang, Jie Xu
DNA methylation plays an important role in gene expression, chromatin stability, and genetic imprinting. In mammals, DNA methylation patterns are written and regulated by DNA methyltransferases (DNMTs), including DNMT1, DNMT3A and DNMT3B. Recent emerging evidence shows that defects in DNMTs are involved in tumor transformation and progression, thus indicating that epigenetic disruptions caused by DNMT abnormalities are associated with tumorigenesis. Herein, we review the latest findings related to DNMT alterations in cancer cells and discuss the contributions of these effects to oncogenic phenotypes...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28123849/dnmt3b-modulates-the-expression-of-cancer-related-genes-and-downregulates-the-expression-of-the-gene-vav3-via-methylation
#7
Irlanda Peralta-Arrieta, Daniel Hernández-Sotelo, Yaneth Castro-Coronel, Marco Antonio Leyva-Vázquez, Berenice Illades-Aguiar
Altered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair genes and its overexpression contributes to oncogenic processes and tumorigenesis in vivo. The purpose of this study was to assess the effect of the overexpression of DNMT3B in HaCaT cells on global gene expression and on the methylation of selected genes to the identification of genes that can be target of DNMT3B...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28111737/expression-of-dna-methylation-related-proteins-in-invasive-lobular-carcinoma-of-breast-comparison-to-invasive-ductal-carcinoma
#8
Yoon Jin Cha, Hye Min Kim, Ja Seung Koo
PURPOSE: We aimed to compare the expression of DNA methylation-related proteins in invasive lobular carcinoma (ILC) of breast with those of invasive ductal carcinoma (IDC) of breast and to assess its potential clinical application. METHODS: Immunohistochemical staining of DNS methylation-related proteins (5-meC, DNMT1, DNMT3B and ISL-1) was applied to tissue microarrays generated from 108 ILCs and 203 IDCs. Protein expression and its correlation with clinicopatholgic variables were statistically analyzed...
January 23, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28107582/immunoexpression-of-hdac1-hdac2-and-hat1-in-actinic-cheilitis-and-lip-squamous-cell-carcinoma
#9
Emanuely da Silva Chrun, Filipe Modolo, Daniella Serafim Couto Vieira, Álvaro Luiz Socorro Borges, Renata Goulart Castro, Filipe Ivan Daniel
BACKGROUND: Acetylation/deacetylation are the most studied covalent histone modifications resulting in transcriptional regulation with histone deacetylases (HDAC) and histone acetyltransferases (HAT) as the main associated enzymes. These enzymes overexpression induces abnormal transcription of key genes that regulate important cellular functions, such as proliferation, cell cycle regulation, and apoptosis. Thus, the expression of different HATs and HDACs has been evaluated in various cancers...
January 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28106784/microrna-29a-alleviates-bile-duct-ligation-exacerbation-of-hepatic-fibrosis-in-mice-through-epigenetic-control-of-methyltransferases
#10
Ya-Ling Yang, Feng-Sheng Wang, Sung-Chou Li, Mao-Meng Tiao, Ying-Hsien Huang
MicroRNA-29 (miR-29) is found to modulate hepatic stellate cells' (HSCs) activation and, thereby, reduces liver fibrosis pathogenesis. Histone methyltransferase regulation of epigenetic reactions reportedly participates in hepatic fibrosis. This study is undertaken to investigate the miR-29a regulation of the methyltransferase signaling and epigenetic program in hepatic fibrosis progression. miR-29a transgenic mice (miR-29aTg mice) and wild-type littermates were subjected to bile duct-ligation (BDL) to develop cholestatic liver fibrosis...
January 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28103274/prenatal-exposure-to-lipopolysaccharide-alters-renal-dna-methyltransferase-expression-in-rat-offspring
#11
Jing Wang, Jinghong Cui, Rui Chen, Youcai Deng, Xi Liao, Yanling Wei, Xiaohui Li, Min Su, Jianhua Yu, Ping Yi
Prenatal exposure to inflammation results in hypertension during adulthood but the mechanisms are not well understood. Maternal exposure to lipopolysaccharide (LPS) alters interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in the fetal environment. As reported in many recent studies, IL-6 regulates DNA methyltransferases (DNMTs) through the transcription factor friend leukemia virus integration 1 (Fli-1). The present study explores the role of intrarenal DNMTs during development of hypertension induced by prenatal exposure to LPS...
2017: PloS One
https://www.readbyqxmd.com/read/28100749/promoted-interaction-of-c-ebp%C3%AE-with-demethylated-cxcr3-gene-promoter-contributes-to-neuropathic-pain-in-mice
#12
Bao-Chun Jiang, Li-Na He, Xiao-Bo Wu, Hui Shi, Wen-Wen Zhang, Zhi-Jun Zhang, De-Li Cao, Chun-Hua Li, Jun Gu, Yong-Jing Gao
: DNA methylation has been implicated in the pathogenesis of chronic pain. However, the specific genes regulated by DNA methylation under neuropathic pain condition remain largely unknown. Here we investigated how chemokine receptor CXCR3 is regulated by DNA methylation and how it contributes to neuropathic pain induced by spinal nerve ligation (SNL) in mice. SNL increased Cxcr3 mRNA and protein expression in the neurons of the spinal cord. Meanwhile, the CpG (5'-cytosine-phosphate-guanine-3') island in the Cxcr3 gene promoter region was demethylated, and the expression of DNA methyltransferase 3b (DNMT3b) was decreased...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28098901/effect-of-evodiamine-and-berberine-on-the-interaction-between-dnmts-and-target-micrornas-during-malignant-transformation-of-the-colon-by-tgf-%C3%AE-1
#13
Chao Huang, Hong Liu, Xiu-Li Gong, Li-Yun Wu, Bin Wen
The tissue microenvironment functions as a crucial player in carcinogenesis, and transforming growth factor-β1 (TGF-β1) within the microenvironment stimulates the formation of neoplasms. Using an in vitro model of malignancy induced by TGF-β1, we assessed the effect of evodiamine and berberine on the interaction between DNA methyltransferases (DNMTs) and target microRNAs (miRNAs) in the model. Colon tissues from neonatal rats 7 days of age were cultured and malignancy was induced by TGF-β1 in vitro for 48 h, and then the tissues were respectively treated with evodiamine and berberine for 24 h...
January 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28093267/interleukin-6-induces-cell-proliferation-of-clear-cell-renal-cell-carcinoma-by-suppressing-hepacam-via-the-stat3-dependent-up-regulation-of-dnmt1-or-dnmt3b
#14
Zhen Quan, Yunfeng He, Chunli Luo, Yang Xia, Yan Zhao, Nanjing Liu, Xiaohou Wu
Interleukin 6 (IL-6), a tumor promoting cytokine, has been largely implicated in the development of renal cell carcinoma (RCC). Hepatocyte cell adhesion molecule (hepaCAM) is a novel tumor suppressor, which is lost or down-regulated in many cancer types including RCC. In the present study, we intensively investigated the connection between IL-6 and hepaCAM in RCC. Our analysis of RCC tissues, adjacent tissues and paired serum samples from RCC patients revealed that IL-6 was elevated in patient serum and RCC tissue, whereas hepaCAM was completely lost or significantly down-regulated...
January 16, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28090275/induction-of-epigenetic-alteration-by-cpuk02-an-ent-kaurenoid-derivative-of-stevioside
#15
Pooneh Mokarram, Zeinab Mohammadi, Saeid Khazayel, Zhang Dayong
BACKGROUND: Dietary polyphenols, such as those found in green tea and red wine, are linked to antitumor activity. They are known to influence many signaling pathways epigenetically within the human body. In this regard, CPUK02 (15-Oxosteviol benzyl ester) is a new ent-kaurenoid derivative of stevioside and exhibits strong anti-cancer activity in vitro and in vivo. Nowadays, the role of epigenetics in cancer has been the subject of intensive study and DNA methylation targeting represents a relevant strategy for cancer treatment...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28052028/establishment-and-characterization-of-hypomethylating-agent-resistant-cell-lines-molm-aza-1-and-molm-dec-5
#16
Eun-Hye Hur, Seung-Hyun Jung, Bon-Kwan Goo, Juhyun Moon, Yunsuk Choi, Dae Ro Choi, Yeun-Jun Chung, Je-Hwan Lee
Two hypomethylating agents (HMAs), azacitidine and decitabine, have demonstrated clinical activities in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML); however, potential problems include development of acquired resistance. HMA-resistant patients have very poor prognosis and this cohort of patients constitutes an important area of research. To understand the mechanisms underlying HMA-resistance and to overcome it, we established an azacitidine-resistant cell line, MOLM/AZA-1 and a decitabine-resistant cell line, MOLM/DEC-5 using MOLM-13...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28043331/avermectin-induced-global-dna-hypomethylation-and-over-expression-of-heat-shock-proteins-in-cardiac-tissues-of-pigeon
#17
Ci Liu, Ye Cao, Shuo Zhou, Pervez Ahmed Khoso, Shu Li
Despite increasing evidences pointing to residues of avermectin (AVM) pose toxic effects on non-target organisms in environment, but the data in pigeon is insufficient. The alteration of global DNA methylation and response of heat shock proteins (Hsps) are important for assessing the AVM toxicity in cardiac tissues of pigeon (Columba livia). To investigate the effects of AVM exposure in cardiac tissues of pigeon, we detected the expression levels of DNA methyltransferases (Dnmts), methylated DNA-binding domain protein 2 (MBD2), and Hsp 60, 70 and 90...
January 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28041964/association-between-dna-methyltransferase-gene-polymorphism-and-parkinson-s-disease
#18
Julio Carlos Pezzi, Cintia Monique Boschmann Ens de Bem, Tatiane Jacobsen da Rocha, Artur F Schumacher-Schuh, Marcia Lorena Fagundes Chaves, Carlos Roberto Rieder, Mara H Hutz, Marilu Fiegenbaum, Ana Luiza Camozzato
Parkinson's disease (PD) is a common and complex neurodegenerative disorder, the second most prevalent, only behind Alzheimer's disease. Recent studies suggest that environmental factors may contribute for neurodegeneration through induction of epigenetic modifications, such as DNA methylation, that is carried out by enzymes, such as DNMT1 and DNMT3B. This present study targeted to investigate the association among DNMT1 and DNMT3B polymorphisms with PD. Five hundred and twenty-two participants (214 PD patients following UK Brain Bank criteria and 308 healthy individuals) were evaluated...
February 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28038969/corrigendum-to-an-association-of-dnmt3b-protein-expression-with-p16ink4a-promoter-hypermethylation-in-non-smoking-female-lung-cancer-with-human-papillomavirus-infection-cancer-lett-226-1-2005-aug-8-77-84
#19
Torng-Sen Lin, Huei Lee, Ruei-A Chen, Ming-Lin Ho, Chia-Yu Lin, Ya-Hui Chen, Yi-Yu Tsai, Ming-Chih Chou, Ya-Wen Cheng
No abstract text is available yet for this article.
December 27, 2016: Cancer Letters
https://www.readbyqxmd.com/read/28007692/micrornas-are-stored-in-human-mii-oocyte-and-their-expression-profile-changes-in-reproductive-aging
#20
Rosalia Battaglia, Maria Elena Vento, Marco Ragusa, Davide Barbagallo, Alessandro La Ferlita, Giovanna Di Emidio, Placido Borzí, Paolo Giovanni Artini, Paolo Scollo, Carla Tatone, Michele Purrello, Cinzia Di Pietro
Maternal RNAs are synthesized by the oocyte during its growth; some of them are utilized for oocyte-specific processes and metabolism, others are stored and used during early development before embryonic genome activation. The appropriate expression of complex sets of genes is needed for oocyte maturation and early embryo development. In spite of the basic role of noncoding RNAs in the regulation of gene expression, few studies have analyzed their role in human oocytes. In this study, we identified the microRNAs (miRNAs) expressed in human metaphase II stage oocytes, and found that some of them are able to control pluripotency, chromatin remodeling, and early embryo development...
December 2016: Biology of Reproduction
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