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https://www.readbyqxmd.com/read/29342861/rational-management-of-iron-deficiency-anaemia-in-inflammatory-bowel-disease
#1
REVIEW
Ole Haagen Nielsen, Christoffer Soendergaard, Malene Elbaek Vikner, Günter Weiss
Anaemia is the most frequent, though often neglected, comorbidity of inflammatory bowel disease (IBD). Here we want to briefly present (1) the burden of anaemia in IBD, (2) its pathophysiology, which mostly arises from bleeding-associated iron deficiency, followed by (3) diagnostic evaluation of anaemia, (4) a balanced overview of the different modes of iron replacement therapy, (5) evidence for their therapeutic efficacy and subsequently, (6) an updated recommendation for the practical management of anaemia in IBD...
January 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29341151/gut-microbiome-influences-on-anastomotic-leak-and-recurrence-rates-following-colorectal-cancer-surgery
#2
REVIEW
S Gaines, C Shao, N Hyman, J C Alverdy
BACKGROUND: The pathogenesis of colorectal cancer recurrence after a curative resection remains poorly understood. A yet-to-be accounted for variable is the composition and function of the microbiome adjacent to the tumour and its influence on the margins of resection following surgery. METHODS: PubMed was searched for historical as well as current manuscripts dated between 1970 and 2017 using the following keywords: 'colorectal cancer recurrence', 'microbiome', 'anastomotic leak', 'anastomotic failure' and 'mechanical bowel preparation'...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29340756/differential-effect-of-a-patient-education-transition-intervention-in-adolescents-with-ibd-vs-diabetes
#3
Silke Schmidt, Henriette Markwart, Franziska Bomba, Holger Muehlan, Annette Findeisen, Martina Kohl, Ingo Menrath, Ute Thyen
Patient education programs (PEPs) to improve disease management are part of standard and regular treatment in adolescents with diabetes. In Germany, youth with inflammatory bowel disease (IBD) receive individual counseling but not PEPs in group settings. Generic PEPs have been developed in order to improve transition from child-centered to adolescent health services. The aim of the study was to investigate the effects of a transition-oriented PEP on quality of life (QoL) and self-management in young patients with IBD (PEP naive), compared to patients with diabetes (familiar with PEPs)...
January 16, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29337786/mechanical-bowel-preparation-before-colorectal-surgery-in-enhanced-recovery-programs-discrepancy-between-the-american-and-european-guidelines
#4
Karem Slim, Alex Kartheuser
No abstract text is available yet for this article.
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337780/efficacy-and-safety-of-sodium-picosulfate-magnesium-citrate-for-bowel-preparation-in-a-physically-disabled-outpatient-population-a-randomized-endoscopist-blinded-comparison-with-ascorbic-acid-enriched-polyethylene-glycol-solution-plus-bisacodyl-the-pico-movi
#5
Elisabeth M H Mathus-Vliegen, Karin van der Vliet, Inge J Wignand-van der Storm, John S Stadwijk
BACKGROUND: Because of its volume, adequate bowel preparation remains problematic in physically unfit patients. OBJECTIVE: This study aimed to compare a small-volume sodium picosulfate/magnesium citrate preparation with a 2-L ascorbic acid-enriched polyethylene glycol solution plus bisacodyl. DESIGN: This study has a noninferiority design, assuming that ascorbic acid-enriched polyethylene glycol solution plus bisacodyl is 70% efficacious in achieving an Ottawa score ≤7 and accepting a difference in success rate of <15% with a target enrollment of 146 patients per group...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29336759/robotic-rectopexy-for-rectal-prolapse-in-pediatric-patients
#6
David J Hiller, Jaime L Bohl, Kristen A Zeller
Rectal prolapse is the protrusion of the rectum out of the anus. Surgical correction can be accomplished via open and minimally invasive abdominal approaches, as well as from the perineum. Robotic rectopexy is an option for minimally invasive treatment of rectal prolapse. There are no studies that have established the efficacy of robotic rectopexy for rectal prolapse in the pediatric population. The aim of this study was to review the experience of robotic rectopexy at a single institution. This is a retrospective review of our pediatric robotic rectopexy experience from 2012 to 2015...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29332407/nutritional-deficiency-during-colonoscopy-preparation-the-forgotten-iatrogeny
#7
Gonçalo Nunes, Ana Teresa Barata, Carla Adriana Santos, Marta Patita, Jorge Fonseca
BACKGROUND AND AIMS: Bowel preparation for colonoscopy induces a semi-fasting state, with a potential negative impact on fragile patients. The present study aims to quantify nutritional deficiency during colonoscopy preparation. METHODS: This was an observational and cross-sectional study. A convenience sample was obtained that included adults that underwent colonoscopy after bowel preparation with Klean-Prep® according to the center protocol. Anthropometric evaluation was performed and nutritional deficiency was calculated via the quantification of energy and protein intake during the 48 hours prior to the examination which was compared with the individuals' needs...
January 15, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29332165/factors-associated-with-anxiety-about-colonoscopy-the-preparation-the-procedure-and-the-anticipated-findings
#8
L A Shafer, J R Walker, C Waldman, C Yang, V Michaud, C N Bernstein, L Hathout, J Park, J Sisler, G Restall, K Wittmeier, H Singh
BACKGROUND: Previous research has assessed anxiety around colonoscopy procedures, but has not considered anxiety related to different aspects related to the colonoscopy process. AIMS: Before colonoscopy, we assessed anxiety about: bowel preparation, the procedure, and the anticipated results. We evaluated associations between patient characteristics and anxiety in each area. METHODS: An anonymous survey was distributed to patients immediately prior to their outpatient colonoscopy in six hospitals and two ambulatory care centers in Winnipeg, Canada...
January 13, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29330098/missed-opportunities-in-colorectal-cancer-prevention-in-patients-with-inadequate-bowel-preparations
#9
Rachel B Issaka, Maneesh H Singh, Carly Rachocki, Lukejohn W Day, Claire Horton, Ma Somsouk
No abstract text is available yet for this article.
January 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29329996/to-prep-or-not-to-prep-that-is-the-question-a-randomized-trial-on-the-use-of-antiflatulent-medication-as-part-of-bowel-preparation-for-patients-having-image-guided-external-beam-radiation-therapy-to-the-prostate
#10
Merrylee McGuffin, Naila Devji, Lyann Kehoe, Anne Carty, Steve Russell, Lisa Di Prospero, Carlo DeAngelis, Alex Kiss, Danny Vesprini, Andrew Loblaw, Laura D'Alimonte
INTRODUCTION: Radiation therapy is a standard treatment option for prostate cancer. With growing use of escalated doses and tighter margins, procedures to limit rectal size variation are needed to reduce prostate motion, increase treatment accuracy, and minimize rectal toxicity. This prospective study was done to determine whether the introduction of an antiflatulent medication would decrease rectal distention at computed tomography (CT) simulation and throughout a course of radiation therapy...
November 4, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29328042/dynamics-of-changes-in-indices-of-endogenous-intoxication-in-patients-with-acute-small-intestinal-obstruction-in-case-of-reamberin-use-in-the-comprehensive-treatment
#11
V Skrypko, A Kovalenko, E Talikova
The objective of this research was to study changes in parameters, characterizing endogenous intoxication in patients with acute small bowel obstruction with Reamberin included into therapy scheme. Full physical examination and surgical treatment of 202 patients with acute small bowel obstruction were conducted. The control group included 30 healthy individuals. Dynamics of such clinical biochemical parameters as medium mass molecules (MMM), malondialdehyde (MDA), diene conjugates (DC) in blood serum were analyzed in preoperative period and on the 1st, 5th and 14th day of postoperative period...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29302876/improving-the-quality-of-inpatient-bowel-preparation-for-colonoscopies
#12
Sarah K Argyropoulos, S Kashif Mahmood, Emily J Campbell, James M Richter
BACKGROUND: Hospitalized patients completing bowel preparation for colonoscopy typically have preparations of poorer quality when compared to outpatient populations. AIMS: Our study aimed to evaluate the effectiveness of a performance improvement program in improving colonoscopy preparation for an inpatient population. METHODS: We identified a cohort of adult patients (n = 641) undergoing an inpatient colonoscopy during a 12-month period at an academic medical center and compared a multifactor intervention group to a historical baseline group...
January 4, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29289528/cystic-fibrosis-colorectal-cancer-screening-consensus-recommendations
#13
Denis Hadjiliadis, Alexander Khoruts, Ann G Zauber, Sarah E Hempstead, Patrick Maisonneuve, Albert B Lowenfels
BACKGROUND & AIMS: Improved therapy has substantially increased survival of persons with cystic fibrosis (CF). But the risk of colorectal cancer (CRC) in adults with CF is 5-10 times greater compared to the general population, and 25-30 times greater in CF patients after an organ transplantation. To address this risk, the CF Foundation convened a multi-stakeholder task force to develop CRC screening recommendations. METHODS: The 18-member task force consisted of experts including pulmonologists, gastroenterologists, a social worker, nurse coordinator, surgeon, epidemiologist, statistician, CF adult, and a parent...
December 28, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29288776/predictive-factors-for-early-onset-and-late-onset-surgical-site-infections-in-patients-undergoing-elective-colorectal-surgery-a-multicentre-prospective-cohort-study
#14
Aina Gomila, Jordi Carratalà, Sebastiano Biondo, Josep MaBadia, Doménico Fraccalvieri, Evelyn Shaw, Vicens Diaz-Brito, Lurdes Pagespetit, Núria Freixas, Montserrat Brugués, Laura Mora, Rafel Perez, Camilo Sanz, Nares Arroyo, Simona Iftimie, Enric Limón, Francesc Gudiol, Miquel Pujol
BACKGROUND: Surgical site infections (SSI) are the leading cause of healthcare-associated infections in acute care hospitals in Europe. However, the risk factors for the development of early- (EO) and late-onset (LO) SSI have not been elucidated. AIM: This study investigated the predictive factors for EO-SSI and LO-SSI in a large cohort of patients undergoing colorectal surgery. METHODS: We prospectively followed-up adult patients undergoing elective colorectal surgery in 10 hospitals (2011-2014)...
December 27, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29282575/factors-influencing-discharge-disposition-after-colectomy
#15
Ahmed M Al-Mazrou, Codruta Chiuzan, Ravi P Kiran
BACKGROUND: Factors associated with discharge destination after colectomy despite accounting for surgical morbidity have not previously been well characterized. This study aims to evaluate perioperative predictors for extended care after complicated and uncomplicated colectomy. METHODS: Patients admitted from home for elective colectomy were identified from the American College of Surgeons, National Surgical Quality Improvement Program, 2012-2013 general and colectomy-targeted datasets...
December 27, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29279076/symptomatic-hyponatremia-after-bowel-preparation-report-of-two-cases-and-literature-review
#16
Juliana Moura Costa, João Bruno Soares
INTRODUCTION: Bowel preparation for colonoscopy and/or colorectal surgery can cause electrolyte imbalances. The risk of electrolyte imbalances seems to be related to the type of bowel cleansing solution, age of patients and comorbidities. CASE REPORT: We report two cases of symptomatic hyponatremia (focal neurological signs and coma) after bowel preparation with sodium picosulfate/magnesium citrate for colonoscopy. In both cases, symptoms related to hyponatremia rapidly disappeared after sodium level correction with intravenous administration of hypertonic saline (3% NaCl)...
November 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29278000/capsule-endoscopy-with-pillcamsb2-versus-pillcamsb3-has-the-improvement-in-technology-resulted-in-a-step-forward
#17
Sofia Xavier, Sara Monteiro, Joana Magalhães, Bruno Rosa, Maria João Moreira, José Cotter
AIM: To compare the findings and completion rate of PillCam® SB2 and SB3. METHODS: This was a retrospective single-center study that included 357 consecutive small bowel capsule endoscopies (SBCE), 173 SB2 and 184 SB3. The data collected included age, gender, capsule type (PillCam® SB2 or SB3), quality of bowel preparation, completion of the examination, gastric and small bowel transit time, small bowel findings, findings in segments other than the small bowel and the detection of specific anatomical markers, such as the Z line and papilla...
December 26, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29276748/extracellular-matrix-bioscaffolds-for-building-gastrointestinal-tissue
#18
REVIEW
George S Hussey, Madeline C Cramer, Stephen F Badylak
Regenerative medicine is a rapidly advancing field that uses principles of tissue engineering, developmental biology, stem cell biology, immunology, and bioengineering to reconstruct diseased or damaged tissues. Biologic scaffolds composed of extracellular matrix have shown great promise as an inductive substrate to facilitate the constructive remodeling of gastrointestinal (GI) tissue damaged by neoplasia, inflammatory bowel disease, and congenital or acquired defects. The present review summarizes the preparation and use of extracellular matrix scaffolds for bioengineering of the GI tract, identifies significant advances made in regenerative medicine for the reconstruction of functional GI tissue, and describes an emerging therapeutic approach...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29274690/colonic-mucosal-bacteria-are-associated-with-inter-individual-variability-in-serum-carotenoid-concentrations
#19
Zora Djuric, Christine M Bassis, Melissa A Plegue, Jianwei Ren, Rena Chan, ElKhansa Sidahmed, D Kim Turgeon, Mack T Ruffin, Ikuko Kato, Ananda Sen
BACKGROUND: Relatively high serum carotenoid levels are associated with reduced risks of chronic diseases, but inter-individual variability in serum carotenoid concentrations is modestly explained by diet. The bacterial community in the colon could contribute to the bioaccessibility of carotenoids by completing digestion of plant cells walls and by modulating intestinal permeability. OBJECTIVE: To evaluate whether colonic bacterial composition is associated with serum and colon carotenoid concentrations...
December 21, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29260916/eudragit-s100-coated-microsponges-for-colon-targeting-of-prednisolone
#20
Amrita Kumari, Ankit Jain, Pooja Hurkat, Ankita Tiwari, Sanjay K Jain
CONTEXT: Microsponge is a novel approach for targeting the drug to the colon for the management of colon ailments such as inflammatory bowel disease. OBJECTIVE: Prednisolone loaded microsponges (PLMs) were prepared and coated with Eudragit S 100 (ES) and evaluated for colon specific drug delivery. MATERIALS AND METHODS: PLMs were prepared using quasi emulsion solvent diffusion technique using ethyl cellulose, triethylcitrate (1% v/v, plasticizer) and polyvinyl alcohol (Mol...
December 20, 2017: Drug Development and Industrial Pharmacy
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