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https://www.readbyqxmd.com/read/28222600/a-rapid-immunoassay-for-detection-of-infliximab-in-whole-blood-using-a-fiber-optic-spr-biosensor
#1
Jiadi Lu, Dragana Spasic, Filip Delport, Thomas Van Stappen, Iris Detrez, Devin Daems, Séverine Vermeire, Ann Gils, Jeroen Lammertyn
Monitoring the concentration of a therapeutic drug antibody, infliximab (IFX), is recommended for enhancing its efficacy in patients with inflammatory bowel disease (IBD). However, IFX concentrations are currently determined in patients' serum/plasma, which requires sample preparation from blood, hence hampering the turnaround time. In this paper, we present a short immunoassay (10 minutes) using fiber-optic SPR (FO-SPR) biosensor for detection of IFX spiked in 100-fold diluted serum, plasma and whole blood...
February 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28220598/applicability-of-99m-tc-labeled-human-serum-albumin-scintigraphy-in-dogs-with-protein-losing-enteropathy
#2
Nina Engelmann, Nele Ondreka, Kerstin von Pückler, Sabrina Mohrs, Julia Sicken, Reto Neiger
BACKGROUND: Diagnosis of protein loss into the gastrointestinal tract using noninvasive techniques is challenging. In people, scintigraphy not only is a sensitive tool to confirm protein-losing enteropathy (PLE), but it also allows for localization of protein loss. HYPOTHESIS/OBJECTIVES: To investigate the feasibility of (99m) Tc-labeled human serum albumin (HSA) scintigraphy in dogs with PLE in comparison with control dogs. ANIMALS: A total of 8 clinically healthy control research dogs and 7 client-owned dogs with gastrointestinal clinical signs and hypoalbuminemia (serum albumin concentration <2...
February 21, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28219690/factors-associated-with-shorter-colonoscopy-surveillance-intervals-for-patients-with-low-risk-colorectal-adenomas-and-effects-on-outcome
#3
Joseph C Anderson, John A Baron, Dennis J Ahnen, Elizabeth L Barry, Roberd M Bostick, Carol A Burke, Robert S Bresalier, Timothy R Church, Bernard F Cole, Marcia Cruz-Correa, Adam S Kim, Leila A Mott, Robert S Sandler, Douglas J Robertson
BACKGROUND & AIMS: Endoscopists do not routinely follow guidelines to survey individuals with low-risk adenomas (LRAs, 1-2 small tubular adenomas, less than 1 cm) every 5-10 years for colorectal cancer (CRC)-many endoscopists recommend shorter surveillance intervals for these individuals. We aimed to identify reasons that endoscopists recommend shorter surveillance intervals for some individuals with LRAs and determine whether timing affects outcomes at follow-up examinations. METHODS: We collected data from 1560 individuals (45-75 years old) who participated in a prospective chemoprevention trial (of vitamin D and calcium) from 2004 through 2008...
February 17, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28214970/optimal-bowel-cleansing-for-colonoscopy-in-the-elderly-patient
#4
Samuel B Ho, Rita Hovsepians, Samir Gupta
Colonoscopy is an important diagnostic and screening tool for colorectal cancer detection and prevention, and adequate bowel preparation is critical for successful colonoscopy. Complications related to colonoscopy, either directly or indirectly related to the procedure, are increased in elderly patients, and the risks and benefits of colonoscopy procedures need to be carefully considered in these patients. Recent studies have shown that 4 L polyethylene glycol with a split preparation is safe and effective for elderly patients, and is the preferred preparation for patients with medical comorbidities...
February 18, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28197054/hyperchloremic-metabolic-acidosis-following-total-gut-irrigation-with-normal-saline-in-pediatric-patients-a-rare-occurrence
#5
Indu Bala, Deepak Dwivedi, Divya Jain, Jai Kumar Mahajan
Use of 0.9% sodium chloride for total gut irrigation (TGI) through nasogastric route is an effective method of bowel preparation in children undergoing colorectal surgeries. TGI with normal saline (NS) can result in nausea, vomiting, abdominal distension, and mild electrolyte imbalance; however, hyperchloremic metabolic acidosis has not been documented. We report two cases of hyperchloremic metabolic acidosis in children posted for colorectal surgery following TGI with NS who were successfully managed.
January 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28195229/international-spinal-cord-injury-bowel-function-basic-data-set-version-2-0
#6
K Krogh, A Emmanuel, B Perrouin-Verbe, M A Korsten, M J Mulcahey, F Biering-Sørensen
STUDY DESIGN: International expert working group. OBJECTIVES: To revise the International Spinal Cord Injury (SCI) Bowel Function Basic Data Set as a standardized format for the collecting and reporting of a minimal amount of information on bowel function in clinical practice and research. SETTING: Working group appointed by the American Spinal injury association (ASIA) and the International Spinal Cord Society (ISCoS). METHODS: The draft prepared by the working group was reviewed by the International SCI Data Set Committee and later by members of the ISCoS Executive and Scientific Committees and the ASIA board...
February 14, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28195032/ph-responsive-carriers-for-oral-drug-delivery-challenges-and-opportunities-of-current-platforms
#7
Lin Liu, WenDong Yao, YueFeng Rao, XiaoYang Lu, JianQing Gao
Oral administration is a desirable alternative of parenteral administration due to the convenience and increased compliance to patients, especially for chronic diseases that require frequent administration. The oral drug delivery is a dynamic research field despite the numerous challenges limiting their effective delivery, such as enzyme degradation, hydrolysis and low permeability of intestinal epithelium in the gastrointestinal (GI) tract. pH-Responsive carriers offer excellent potential as oral therapeutic systems due to enhancing the stability of drug delivery in stomach and achieving controlled release in intestines...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28191706/g-protein-coupled-estrogen-receptor-and-estrogen-receptor-ligands-regulate-colonic-motility-and-visceral-pain
#8
M Zielińska, J Fichna, M Bashashati, S Habibi, A Sibaev, J-P Timmermans, M Storr
BACKGROUND: Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional gastrointestinal (GI) disorder, which occurs more frequently in women than men. The aim of our study was to determine the role of activation of classical estrogen receptors (ER) and novel membrane receptor, G protein-coupled estrogen receptor (GPER) in human and mouse tissue and to assess the possible cross talk between these receptors in the GI tract. METHODS: Immunohistochemistry was used to determine the expression of GPER in human and mouse intestines...
February 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28188978/split-dose-bowel-preparation-with-polyethylene-glycol-for-colonoscopy-performed-under-propofol-sedation-is-there-an-optimal-timing
#9
Alaa Alghamry, Sureshkumar K Ponnuswamy, Aditya Agarwal, Hadi Moattar, Stephanie T Yerkovich, Ann E Vandeleur, James Thomas, John Croese, Tony Rahman, Ruth Hodgson
AIM: Aspiration risk, especially with propofol sedation, remains a concern with split-dose bowel preparation using polyethylene glycol, which involves up to one liter of preparation intake close to the procedure time. We aim to identify the ideal timing of bowel preparation that achieves optimal colon cleansing with no increased risk of aspiration in all patients undergoing combined esophagogastroduodenoscopy (EGD) and colonoscopy with propofol sedation. METHODS: We prospectively recruited 892 consecutive patients undergoing simultaneous EGD and colonoscopy...
February 11, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28188722/prevalence-of-hypokalemia-before-and-after-bowel-preparation-for-colonoscopy-in-high-risk-patients
#10
Ankie Reumkens, Ad A M Masclee, Bjorn Winkens, Cees T van Deursen, Silvia Sanduleanu, C Minke Bakker
BACKGROUND AND AIMS: Bowel preparation for colonoscopy should not cause significant shifts in systemic electrolyte concentrations. We recently encountered 2 cases of severe postcolonoscopy hypokalemia with fatal consequences, prompting us to conduct a study to explore the magnitude of and risk factors for hypokalemia associated with bowel preparation. We paid specific attention to higher risk subgroups, in particular diuretic users, hospitalized patients and patients estimated at to be high risk by the gastroenterologist...
February 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28187404/potentized-estrogen-in-homeopathic-treatment-of-endometriosis-associated-pelvic-pain-a-24-week-randomized-double-blind-placebo-controlled-study
#11
Marcus Zulian Teixeira, Sérgio Podgaec, Edmund Chada Baracat
OBJECTIVE: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). STUDY DESIGN: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score≥5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain...
January 25, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28173768/-bowel-prep-hyponatremia-a-state-of-acute-water-intoxication-facilitated-by-low-dietary-solute-intake-case-report-and-literature-review
#12
Martin Windpessl, Christoph Schwarz, Manfred Wallner
BACKGROUND: Symptomatic hyponatremia is considered a rare complication of oral bowel preparation for colonoscopy. The pathophysiology underlying this phenomenon has been widely regarded as a mere sequela of excessive arginine vasopressin (AVP) release. CASE PRESENTATION: This case describes a 61-year old woman who developed acute hyponatremic encephalopathy when preparing for elective outpatient lower endoscopy. She had had negligible oral solute intake for two days and ingested four liters of clear fluid within two hours...
February 7, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28160390/angiotensin-ii-type-ii-receptors-and-colonic-dysmotility-in-2-4-dinitrofluorobenzenesulfonic-acid-induced-colitis-in-rats
#13
M G Zizzo, M Auteri, A Amato, G Caldara, D Nuzzo, M Di Carlo, R Serio
BACKGROUND: Angiotensin II (Ang II), the main peptide of the renin-angiotensin system (RAS), has been suggested to be involved in inflammatory bowel diseases. Since RAS has emerged as gut motility regulator, and dysmotility is associated with intestinal inflammation, our objective was to investigate in rat 2,4-dinitrobenzenesulfonic acid (DNBS)-induced colitis the functionality of RAS and its contribution to colonic motor alterations. METHODS: The effects of Ang II on the longitudinal colonic muscular contractility of control and DNBS-treated rats were characterized in vitro...
February 3, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28153961/novel-insight-into-the-role-of-microbiota-in-colorectal-surgery
#14
REVIEW
Radu Bachmann, Daniel Leonard, Nathalie Delzenne, Alex Kartheuser, Patrice D Cani
Recent literature undeniably supports the idea that the microbiota has a strong influence on the healing process of an intestinal anastomosis. Understanding the mechanisms by which the bacterial community of the gut influences intestinal healing could open the door for new preventive and therapeutic approaches. Among the different mechanisms, data have shown that the production of specific reactive oxygen species (ROS) and the activation of specific formyl peptide receptors (FPRs) regulate intestinal wound healing...
February 2, 2017: Gut
https://www.readbyqxmd.com/read/28153604/ectopic-expression-of-sigirr-in-the-colon-ameliorates-colitis-in-mice-by-downregulating-tlr4-nf-%C3%AE%C2%BAb-overactivation
#15
Jinlin Liu, Yanxia Chen, Dongsheng Liu, Wei Liu, Sijun Hu, Nanjin Zhou, Yong Xie
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by uncontrolled immune responses in inflamed mucosa, especially the TLR (Toll-like receptor) signaling pathway. Single Ig domain containing IL-1 receptor-related molecule (SIGIRR), a negative regulator of the TLR signaling pathway, whether had a therapeutic effect in a mouse model of IBD, and the underlying mechanism has not been investigated. METHODS: Coacervation was used to prepare chitosan/pUNO-SIGIRR nanoparticles...
January 30, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28151800/comparative-effectiveness-and-risks-of-bowel-preparation-before-elective-colorectal-surgery
#16
Sarah E Koller, Katherine W Bauer, Brian L Egleston, Radhika Smith, Matthew M Philp, Howard M Ross, Nestor F Esnaola
OBJECTIVE: The objective of this study was to determine the relationship between bowel preparation and surgical site infections (SSIs), and also other postoperative complications, after elective colorectal surgery. BACKGROUND: SSI is a major source of postoperative morbidity/costs after colorectal surgery. The value of preoperative bowel preparation to prevent SSI remains controversial. METHODS: We analyzed 32,359 patients who underwent elective colorectal resections in the American College of Surgeons National Surgery Quality Improvement Program database from 2012 to 2014...
February 1, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28147395/bowel-preparation-for-colonoscopy-in-diabetic-patients
#17
Marco Antonio Alvarez-Gonzalez, Juana A Flores-Le Roux
No abstract text is available yet for this article.
February 2017: Endoscopy
https://www.readbyqxmd.com/read/28147394/bowel-preparation-in-diabetic-patients-undergoing-colonoscopy
#18
Alba Panarese
No abstract text is available yet for this article.
February 2017: Endoscopy
https://www.readbyqxmd.com/read/28147380/promises-and-dangers-of-combination-therapy
#19
REVIEW
Wolfgang Kruis, Phuong G Nguyen, Julia Morgenstern
The efficiency of the existing methods of treating inflammatory bowel disease (IBD) is limited. There are 2 ways to address this problem - either create new treatment modalities or optimize current therapies. Optimisation may be accomplished by using combinations of established therapeutic strategies. With regard to topically acting compounds such as 5-aminosalicylic acid, combining oral and rectal preparations is a commonly used method. Another commonly used combination is anti-tumor necrosis factor (TNF)-α antibody modalities together with immunosuppressants (thiopurines, methotrexate)...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28147356/infliximab-biosimilar-remsima%C3%A2-in-therapy-of-inflammatory-bowel-diseases-patients-experience-from-one-tertiary-inflammatory-bowel-diseases-centre
#20
M Kolar, D Duricova, M Bortlik, V Hruba, N Machkova, K Mitrova, K Malickova, M Lukas, Milan Lukas
BACKGROUND: The evidence on the efficacy and safety of biosimilar infliximab (IFX) in patients with inflammatory bowel diseases (IBD) is sparse. METHODS: Consecutive IBD patients visiting our centre were included. One cohort composed of prospectively followed patients who were switched from original to biosimilar IFX between January and March 2015. The second cohort included retrospectively assessed anti-tumor necrosis factor α-naïve patients who started therapy between January 2015 and January 2016...
2017: Digestive Diseases
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