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Periodontal therapy

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https://www.readbyqxmd.com/read/29229075/does-periodontal-inflammation-affect-glycosylated-haemoglobin-level-in-otherwise-systemically-healthy-individuals-a-hospital-based-study
#1
Rosamma Joseph Vadakkekuttical, Priyanka Chand Kaushik, Jerry Mammen, Joseraj Manaloor George
BACKGROUND AND OBJECTIVES: Microbial biofilm and host susceptibility play an important role in the initiation and progression of periodontitis. Periodontitis is considered the sixth complication of diabetes mellitus and a bidirectional relationship exists between diabetes and periodontitis. This cross-sectional observational study was undertaken to evaluate the glycosylated haemoglobin (HbA1c) level in chronic periodontitis. METHODS: The study involved 100 subjects...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29229072/the-role-of-subepithelial-connective-tissue-graft-for-reconstruction-of-interdental-papilla-clinical-study
#2
Ena Sharma, Anuj Sharma, Kamaljit Singh
BACKGROUND: The ideal goal of periodontal therapy is regeneration of the lost periodontium. However regeneration of the lost interdental papilla has been elusive. Therefore the ability of rebuilding lost papillae in the maxillary segment has become one of the major challenges in periodontal plastic surgery. OBJECTIVES OF THE STUDY: To evaluate the success and predictability of surgical technique using a sub epithelial connective tissue graft interposed in a coronally displaced flap to reconstruct the lost interdental papillae...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29226955/stem-cells-rescue-cardiomyopathy-induced-by-p-gingivalis-lps-via-mir-181b
#3
Tung-Sheng Chen, Sarnai Battsengel, Chia-Hua Kuo, Lung-Fa Pan, Yueh-Min Lin, Chun-Hsu Yao, Yueh-Sheng Chen, Feng-Huei Lin, Wei-Wen Kuo, Chih-Yang Huang
Systemic inflammation induced by bacterial infection is one of several causative agents for cardiovascular disorders in patients with periodontal disease. Experimental results indicate that miRNAs play important roles in systemic inflammation induced by endotoxins. Further evidence states that stem cell based therapy shows potential in the treatment of inflammatory responses induced by sepsis. This study investigates if stem cells show protective effects on cardiomyocyte damage induced by porphyromonas gingivalis-LPS (Pg-LPS) through regulating miRNAs...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29219193/the-effect-of-horizontal-and-vertical-furcation-involvement-on-molar-survival-a-retrospective-study
#4
L Nibali, C Sun, A Akcalı, Y C Yeh, Y K Tu, N Donos
BACKGROUND: Periodontal involvement of the furcation area (furcation involvement, FI) has been reported to confer to molars a higher risk of tooth loss. AIMS: The aim of this retrospective analysis was to assess the effect of FI on disease progression and tooth loss in molars of patients with chronic periodontitis undergoing supportive periodontal therapy (SPT) in a UK private practice setting. MATERIALS AND METHODS: Six-hundred and thirty-three molars were analysed in 100 chronic periodontitis patients treated with active periodontal therapy (APT) and followed up in SPT for at least 5 years...
December 8, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29218774/impact-of-antiinfective-periodontal-therapy-on-parameters-of-vascular-health
#5
Yvonne Jockel-Schneider, Markus Bechtold, Imme Haubitz, Stefan Störk, Stefan Fickl, Inga Harks, Martin Eigenthaler, Oliver Vollrath, Johannes Baulmann, Ulrich Schlagenhauf
AIM: This study assessed the impact of antiinfective periodontal therapy on the status of vascular health. MATERIALS AND METHODS: Periodontal and vascular health of 55 patients with severe untreated chronic periodontitis was evaluated before and 12 months after antiinfective periodontal therapy. Observed parameters were bleeding on probing (BoP), pocket probing depth (PPD), periodontal inflamed surface area index (PISA), pulse wave velocity (PWV), augmentation index (AIx), central pulse pressure (PPao), and peripheral systolic pressure (RRsys)...
December 8, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29217959/periodontal-therapy-with-0-25-lemongrass-oil-mouthwash-in-reducing-risk-of-cardiovascular-diseases-a-3-arm-prospective-parallel-experimental-study
#6
Dany S Subha, Tangde Pradeep
Background: Periodontal disease is associated with cardiovascular diseases because of its role in host immune-inflammatory response. Serum lipids are the commonest risk factors between periodontal disease and cardiovascular diseases. Materials and Method: A double blinded randomised clinical trial was carried out among 45 subjects with generalised severe periodontitis. They were divided into 3-groups of 15 subjects each. Group A: 0.25% lemongrass oil mouthwash, Group B: 0...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29213288/microrna-214-suppresses-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells-by-targeting-atf4
#7
Siqi Yao, Wei Zhao, Qianmin Ou, Lanchen Liang, Xuefeng Lin, Yan Wang
Periodontitis is the main cause of adult tooth loss. Stem cell-based tissue engineering has become a promising therapy for periodontitis treatment. To date, human periodontal ligament stem cells (hPDLSCs) have been shown to be a favorable source for tissue engineering, but modulatory mechanisms of hPDLSCs remain unclear. Approximately 60% of mammalian genes are the targets of over 2000 miRNAs in multiple human cell types, and miRNAs are able to influence various biological processes in the human body, including bone formation...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29211309/statins-in-nonsurgical-and-surgical-periodontal-therapy-a-systematic-review-and-meta-analysis-of-preclinical-in-vivo-trials
#8
REVIEW
K Bertl, I Steiner, N Pandis, K Buhlin, B Klinge, A Stavropoulos
The cholesterol-lowering drugs, statins, possess anti-inflammatory, antimicrobial and pro-osteogenic properties, and thus have been tested as an adjunct to periodontal treatment. The present systematic review aimed to answer the following focused research question: What is the effect of local and/or systemic statin use on periodontal tissues in preclinical in vivo studies of experimentally induced periodontitis (EIP) and/or acute/chronified periodontal defect (ACP) models? A literature search (of Medline/PubMed, Embase/Ovid, CENTRAL/Ovid) using the following main eligibility criteria was performed: (i) English or German language; (ii) controlled preclinical in vivo trials; (iii) local and/or systemic statin use in EIP and/or ACP models; and (iv) quantitative evaluation of periodontal tissues (i...
December 6, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29211121/evolution-of-periodontal-disease-immune-response-and-rank-rankl-opg-system
#9
Fabrício Gibertoni, Meire Ellen Ligia Sommer, Marcelo Augusto Marretto Esquisatto, Maria Esméria Corezola do Amaral, Camila Andrea de Oliveira, Thiago Antônio Moretti de Andrade, Fernanda Aparecida Sampaio Mendonça, Milton Santamaria-Jr, Maíra Felonato
The aim of this study was to evaluate markers of bone loss and immune response present in evolution of periodontal disease. One hundred and two Wistar rats were divided into three animals groups: PD0, without ligation and PD15 days and PD60 days, submitted to ligation placement with a sterile 3-0 silk cord in the cervical region of the upper first molar on both sides. Samples were obtained from the gingival tissue for histomorphometric analysis, immunohistochemical analysis of RANK, RANKL, OPG, characterization of the inflammatory infiltrate, quantification of nitric oxide, MCP-1, RANTES, IP10 chemokines, and expression of the TGF-b1, VEG, and bFGF...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29208508/scientific-evidence-on-the-links-between-periodontal-diseases-and-diabetes-consensus-report-and-guidelines-of-the-joint-workshop-on-periodontal-diseases-and-by-the-international-diabetes-federation-and-the-european-federation-of-periodontology
#10
Mariano Sanz, Antonio Ceriello, Martin Buysschaert, Iain Chapple, Ryan T Demmer, Filippo Graziani, David Herrera, Søren Jepsen, Luca Lione, Phoebus Madianos, Manu Mathur, Eduard Montanya, Lior Shapira, Maurizio Tonetti, Daniel Vegh
BACKGROUND: Diabetes and periodontitis are chronic non-communicable diseases independently associated with mortality and have a bidirectional relationship. AIMS: To update the evidence for their epidemiological and mechanistic associations and re-examine the impact of effective periodontal therapy upon metabolic control (glycated haemoglobin, HbA1C). EPIDEMIOLOGY: There is strong evidence that people with periodontitis have elevated risk for dysglycaemia and insulin resistance...
December 2, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29207843/biosynthesis-characterization-and-antibacterial-efficacy-of-silver-nanoparticles-derived-from-endophytic-fungi-against-p-gingivalis
#11
Kiran Rahul Halkai, Jayashree A Mudda, Vasundhara Shivanna, Vandana Rathod, Rahul S Halkai
Introduction: Microbial resistance to existing antimicrobial agents in periodontal therapy is a growing problem. Therefore, there is a need for development of new antimicrobial agents. Aim: To biosynthesize and characterize Silver Nanoparticles (AgNPs) using endophytic fungi and to evaluate the antibacterial efficacy against P. gingivalis. Materials and Methods: Cut leaf segments of Withania Somnifera (Ashwagandha) were used to isolate the fungi...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204304/langerhans-cell-histiocytosis-a-diagnostic-challenge-in-the-oral-cavity
#12
Mehmet Ali Altay, Alper Sindel, Öznur Özalp, Burak Kocabalkan, İrem Hicran Özbudak, Ramazan Erdem, Ozan Salim, Dale A Baur
Background: Langerhans cell histiocytosis (LCH) is a rare disorder of the reticuloendothelial system with unknown etiology. This report aims to present a case of LCH with diffuse involvement of the oral cavity and to raise awareness of the distinguishing features of this diagnostically challenging entity. Case Report: A 26-year-old male patient presented with complaints of teeth mobility, intense pain, and difficulty in chewing. Intraoral and radiological examinations revealed generalized gingival hyperplasia and severe teeth mobility with widespread alveolar bone loss...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/29201598/use-of-probiotics-and-oral-health
#13
REVIEW
Robert P Allaker, Abish S Stephen
Purpose of Review: The purpose of this study is to critically assess recent studies concerning the use of probiotics to control periodontal diseases, dental caries and halitosis (oral malodour). Recent Findings: Clinical studies have shown that probiotics when allied to conventional periodontal treatment can ameliorate microbial dysbiosis and produce significant improvement in clinical indicators of disease. However, this effect is often not maintained by the host after the end of probiotic use...
2017: Current Oral Health Reports
https://www.readbyqxmd.com/read/29201597/current-concepts-of-epigenetics-and-its-role-in-periodontitis
#14
REVIEW
Lena Larsson
Purpose: The focus of this review is to provide an overview of the recent findings on the role of epigenetic mechanisms in periodontal disease, including disease susceptibility, progression, and as potential treatment options. Recent Findings: The findings on the influence of oral pathogens on epigenetic regulation of pathogen recognition receptors, such as Toll-like receptors, as well as pro-inflammatory cytokines suggest an important role for epigenetics in the regulation of the host immune response...
2017: Current Oral Health Reports
https://www.readbyqxmd.com/read/29197435/gap-analysis-of-older-adults-with-type-2-diabetes-receiving-nonsurgical-periodontal-therapy
#15
REVIEW
Enihomo Obadan-Udoh, Samantha Jordan, Olubukola Mudah, Wenche Borgnakke, Mary Tavares
OBJECTIVE: Twenty percent of the elderly US population is diagnosed with diabetes. The elderly are at a higher risk of developing serious complications from diabetes. Regular professional dental care may help control blood glucose levels and thereby diabetes complications. Since such potential benefits could play a clinically significant role in diabetes management, our aim was to identify and review relevant evidence among the older population. MATERIALS AND METHODS: Electronic databases were searched for periodontal intervention studies using modified search terms from previous systematic reviews...
December 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/29197129/patient-self-care-of-periodontal-pocket-infections
#16
REVIEW
Nicole Birgit Arweiler, Thorsten M Auschill, Anton Sculean
Treatment of periodontitis aims to control the infection caused by the periodontal pathogenic flora and includes mechanical debridement of root surfaces to disrupt the supragingival and subgingival biofilm. As periodontal pockets of ≤ 5 mm can be perform in a stable condition and may not need additional therapy, the ability and the willingness of the patient to perform good oral hygiene on a long-term basis are of utmost importance for ensuring long-term success of periodontal treatment. In this context, the aim of all home-care measures must be the optimal control of plaque biofilm in order to prevent or treat gingival inflammation as a primary stage of periodontitis...
December 1, 2017: Periodontology 2000
https://www.readbyqxmd.com/read/29196831/laser-for-bone-healing-after-oral-surgery-systematic-review
#17
REVIEW
Claudio Noba, Anna Carolina Volpi Mello-Moura, Thais Gimenez, Tamara Kerber Tedesco, Cacio Moura-Netto
The purpose of this study is to perform a systematic review on the use of lasers in oral surgery for bone healing. Selection of articles was carried out by two evaluators in Pubmed and Web of Science databases for published articles and OpenGray for gray literature. Search strategy was developed based on the PICO Question "Does the use of lasers after oral surgery improve bone healing?". Eligibility criteria were: being on laser; evaluate bone healing; involve oral surgery; do not be about implant, periodontics, orthodontics, osteonecrosis or radiotherapy, nor revisions, clinical cases, etc...
December 1, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29194795/description-of-the-periodontal-pocket-in-preclinical-models-limitations-and-considerations
#18
REVIEW
Nikolaos Donos, Jung-Chul Park, André Vajgel, Bruna de Carvalho Farias, Xanthippi Dereka
Establishment of periodontal health and regeneration of the lost periodontal tissues are always the ultimate goal of periodontal treatment. The development of new therapeutic approaches raises the necessity for appropriate experimental models that present periodontal structures and healing capability comparable to humans. Preclinical research and extrapolation of the data to human conditions remains a stage of great importance before the clinical application of the new biomaterials and techniques. Periodontal pockets/defects in preclinical models can be induced experimentally through acute or chronic or a combination of both (induced) modalities...
November 30, 2017: Periodontology 2000
https://www.readbyqxmd.com/read/29194794/the-periodontal-pocket
#19
REVIEW
Nikolaos Donos
Periodontal disease is synonymous with the presence of periodontal pockets, and very often the clinical success of periodontal therapy is based on periodontal pocket depth reduction. Therefore, in the fields of periodontology and implant dentistry, significant research effort has been placed on the etiopathogenesis, diagnosis and treatment of periodontal/peri-implant disease and as a consequence on pocket pathology. In this volume of Periodontology 2000, the in-depth reviews include topics ranging from preclinical models, anatomy and structure of tissues, and molecular and bacterial components, to treatments of pockets around teeth and implants...
November 30, 2017: Periodontology 2000
https://www.readbyqxmd.com/read/29193859/comparative-evaluation-of-salivary-hepatocyte-growth-factor-in-smokers-and-non-smokers-with-chronic-periodontitis
#20
Sanjeela Guru, Sheena Elizabeth Sam, Sukanya Rajan, Shyam Padmanabhan
AIM: Hepatocyte growth factor (HGF) is a multifunctional cytokine with a wide range of actions, and plays a role in periodontal disease (PD) progression. Smoking significantly increases the risk for PD progression. Thus, aim of the present study was to estimate salivary HGF levels of non-smokers and smokers with chronic periodontitis (CP) and to compare its levels before and after therapy. METHODS: A total of 75 participants were recruited and divided into three groups: group 1 included 25 healthy participants, group 2 included 25 non-smokers with CP, and group 3 included 25 smokers with CP...
November 29, 2017: Journal of Investigative and Clinical Dentistry
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