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https://www.readbyqxmd.com/read/28733984/implant-treatment-in-pharmacologically-immunosuppressed-liver-transplant-patients-a-prospective-controlled-study
#1
Víctor Paredes, Rosa María López-Pintor, Jesús Torres, Juan Carlos de Vicente, Mariano Sanz, Gonzalo Hernández
OBJECTIVES: The main objective of this prospective study was to evaluate the long-term outcome of implant therapy in liver transplant patients (LTP). The secondary goal was to assess several implant- and patient-dependent variables, such as peri-implantitis (PI), peri-implant mucositis (PIM), bone loss (BL), and immediate postoperative complications. MATERIAL AND METHODS: Two groups, including 16 pharmacologically immunosuppressed LTP and 16 matched controls, received 52 and 54 implants, respectively, between 1999 and 2008...
July 21, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28721992/comparative-evaluation-of-effectiveness-of-intra-pocket-anesthetic-gel-and-injected-local-anesthesia-during-scaling-and-root-planing-a-split-mouth-clinical-trial
#2
Kalyan Chintala, Sandhya Pavan Kumar, K Raja V Murthy
BACKGROUND AND AIM: Pain control is an important outcome measure for successful periodontal therapy. Injected local anesthesia has been used to secure anesthesia for scaling and root planing (SRP) and continues to be the anesthetic of choice for pain control. Alternatively, intra-pocket anesthetic gel has been used as an anesthetic during SRP. Hence, this clinical trial was done to compare the effectiveness of intra-pocket anesthetic gel and injected local anesthesia during SRP and also to assess the influence of intra-pocket anesthetic gel on treatment outcomes in chronic periodontitis patients...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28719833/in-silico-search-of-inhibitors-of-streptococcus-mutans-for-the-control-of-dental-plaque
#3
Rodrigo Ochoa, María Cecilia Martínez-Pabón, María Adelaida Arismendi-Echeverri, Willer Leandro Rendón-Osorio, Carlos Enrique Muskus-López
Biofilm is an extremely complex microbial community arranged in a matrix of polysaccharides and attached to a substrate. Its development is crucial in the pathophysiology of oral infections like dental caries, as well as in periodontal, pulp, and periapical diseases. Streptococcus mutans is one of the most effective microorganisms in lactic acid production of the dental biofilm. Identifying essential Streptococcus mutans proteins using bioinformatics methods helps to search for alternative therapies. To this end, the bacterial genomes of several Streptococcus mutans strains and representative strains of other cariogenic and non-cariogenic bacteria were analysed by identifying pathogenicity islands and alignments with other bacteria, and by detecting the exclusive genes of cariogenic species in comparison to the non-pathogenic ones...
July 1, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28717879/comparison-of-the-effect-of-activated-or-non-activated-prp-in-various-concentrations-on-osteoblast-and-fibroblast-cell-line-proliferation
#4
Surena Vahabi, Zahra Yadegari, Hossein Mohammad-Rahimi
Platelet-rich plasma (PRP) contains growth factors which positively affect cell proliferation, cell differentiation, chemotaxis and intracellular matrix synthesis. All these processes are involved in wound healing and tissue regeneration; thus, PRP as a source of growth factors can be used in periodontal regenerative therapies. The purpose of the present study was to assess the effect of various concentrations of activated and non-activated PRP on proliferation of osteoblasts and fibroblasts in vitro. PRP was obtained from three healthy volunteers...
July 17, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28706787/effect-of-scaling-root-planing-on-the-activity-of-alp-in-gcf-serum-of-patients-with-gingivitis-chronic-and-aggressive-periodontitis-a-comparative-study
#5
Nishi Singh, Siddhartha Chandel, Harmurti Singh, Amiya Agrawal, A N Savitha
INTRODUCTION: Host response and environmental factors are known to modify periodontal status adversely. Presently serum, saliva, and GCF are being investigated for its biochemical constituents. GCF contains array of biochemical factors, offering potential use as a diagnostic or prognostic biomarker of the biologic state of the periodontium in health and disease. Alkaline phosphatase is produced locally in the periodontium and shows positive correlation with disease activity and PD. Present study was designed to analyze the levels of ALP in GCF and serum of patients with gingivitis, chronic & aggressive periodontitis before and after SRP & to compare the difference within the study groups...
May 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28701797/antimicrobial-effect-of-blue-light-using-porphyromonas-gingivalis-pigment
#6
Ayaka Yoshida, Haruka Sasaki, Toshizo Toyama, Mitsunori Araki, Jun Fujioka, Koichi Tsukiyama, Nobushiro Hamada, Fumihiko Yoshino
The development of antibiotics cannot keep up with the speed of resistance acquired by microorganisms. Recently, the development of antimicrobial photodynamic therapy (aPDT) has been a necessary antimicrobial strategy against antibiotic resistance. Among the wide variety of bacteria found in the oral flora, Porphyromonas gingivalis (P. gingivalis) is one of the etiological agents of periodontal disease. aPDT has been studied for periodontal disease, but has risks of cytotoxicity to normal stained tissue. In this study, we performed aPDT using protoporphyrin IX (PpIX), an intracellular pigment of P...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699678/the-effect-of-furcation-involvement-on-tooth-loss-in-a-population-without-regular-periodontal-therapy
#7
Luigi Nibali, Anna Krajewski, Nikos Donos, Henry Völzke, Christiane Pink, Thomas Kocher, Birte Holtfreter
AIM: We aimed to assess the association between furcation involvement (FI) and tooth loss for subjects not undergoing regular periodontal treatment. MATERIALS AND METHODS: Data from 2333 subjects participating in the baseline and 11-year follow-up of the Study of Health in Pomerania (SHIP) were used. All subjects had half-mouth periodontal examinations, including FI in one upper and one lower molar, at baseline. A total of 1897 subjects and 3267 molars were included in the final analysis...
July 12, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28698305/periodontitis-a-global-disease-and-the-primary-care-provider-s-role
#8
REVIEW
Martin S Lipsky, Keith Trevor Paskett, Andrew Jacob Gross, Val Joseph Cheever
Individuals who regularly visit a primary care provider (PCP) may not see a dentist, creating opportunities for PCPs to improve oral health. However, a lack of expertise among PCPs may limit their impact to improve public oral health. Using a non-systematic literature review, this article summarises the relevant literature about periodontitis. Periodontitis affects 10% to -15% of the world's population. Caused by bacterial inflammation in gingival pockets, periodontal disease can destroy tissues surrounding the teeth...
July 11, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28693688/effects-of-aging-on-the-proliferation-and-differentiation-capacity-of-human-periodontal-ligament-stem-cells-%C3%A2
#9
Du Tingting, Liu Na, Gu Bin, Li Ying, Yuan Yifang, Zhang Wei, Zhang Tong
Objective The aim of this study is to investigate the proliferation, differentiation and apoptosis of periodontal ligament stem cells (PDLSC) derived from different aged donors, and to evaluate the effects of aging on the biological characteristics of PDLSC.Methods Periodontal ligament tissues were obtained from 24 surgically extracted human premolars during orthodontics therapy. The specimens were divided into three groups according to the donor's age. Group A: 18-20 years, group B: 30-35 years, group C: 45-50 years...
June 10, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28692925/role-of-the-adjunctive-antimicrobial-photodynamic-therapy-to-periodontal-treatment-at-plasmatic-oxidative-stress-and-vascular-behavior
#10
L M Barin, R C S Barcelos, L T Vey, F M Pillusky, V M Palma, K Z Kantorski, M E Bürger, R M Maciel, C C Danesi
BACKGROUND: To evaluate for the first time in vivo the effects of methylene blue (MB) photosensitizer dissolved in ethanol in antimicrobial photodynamic therapy (aPDT) as adjuvant periodontal treatment, at plasmatic oxidative stress and vascular behavior in rat model. METHODS: Wistar rats were divided into negative control (NC, no periodontitis) and positive control (PC, with periodontitis, without any treatment). The other groups had periodontitis and were treated with scaling and root planing (SRP); SRP+aPDT+MB dissolved in water (aPDT I); SRP+aPDT+MB dissolved in ethanol (aPDT II)...
June 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28691886/salivary-levels-of-nlrp3-inflammasome-related-proteins-as-potential-biomarkers-of-periodontal-clinical-status
#11
Diana M Isaza-Guzmán, Verónica M Medina-Piedrahíta, Carolina Gutiérrez-Henao, Sergio I Tobón-Arroyave
BACKGROUND: Emerging evidence suggests that the activation of inflammasomes plays a central mechanism in the pathogenesis of periodontitis. This study aimed to compare the salivary levels of nod-like receptor family pyrin domain containing protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cysteine aspartase-1 (caspase-1), and interleukin-1 beta (IL-1β) from individuals with aggressive (AgP) or chronic periodontitis (CP) and healthy controls (HC), as well as elucidate its association with the periodontal clinical status...
July 10, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28690099/electrospun-polymeric-nanofibers-new-horizons-in-drug-delivery
#12
REVIEW
Shreya Thakkar, Manju Misra
Nanofibers obtained using electrospinning technique are being used since ages especially in fields of textile industry, sensors, filters, protective clothing and tissue engineering. Their use as drug delivery system is an emerging platform in the field of pharmaceuticals and now-a-days formulation scientists are paying great attention to the technology due to several advantages prime being easy modulation of drug release profile depending upon the properties of polymer/polymeric blends/other materials used...
July 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28688510/insufficient-evidence-to-claim-that%C3%A2-photodynamic-therapy-as-an%C3%A2-adjunct-to-scaling-and-root-planing-improves-periodontal-parameters-compared-with-adjunctive%C3%A2-antibiotics
#13
Tahira Devji
No abstract text is available yet for this article.
June 23, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28687322/chemically-modified-tetracyclines-an-emerging-host-modulator-in-chronic-periodontitis-patients-a-randomized-double-blind-placebo-controlled-clinical-trial
#14
Abdullah A Alyousef, Darshan Devang Divakar, Muzaheed, Abdulaziz Abdullah Al Kheraif
Although periodontal diseases are caused by some of the specific pathogens, most of the tissue damage is caused by the host reaction to disease and not actually by the infections. Therefore, host modulatory therapy (HMT) has advanced benefit for the treatment of periodontitis, which works basically by reducing tissue destruction and regeneration in periodontium by altering the critical aspects of host response regulation and up regulating defensive regenerative responses. The present study was conducted with the goal to test an innovative therapeutic option using chemically modified tetracycline in patients affected with generalized, moderate and severe chronic periodontitis...
July 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28683765/periodontal-regenerative-therapy-with-enamel-matrix-derivative-in-the-treatment-of-intrabony-defects-a-prospective-2-year-study
#15
Fumi Seshima, Hideto Aoki, Takahiro Takeuchi, Eiichi Suzuki, Daisuke Irokawa, Asako Makino-Oi, Hiroki Sugito, Sachiyo Tomita, Atsushi Saito
OBJECTIVE: To date, enamel matrix derivative (EMD) has been considered to be one of the few biomaterials for clinical use capable of demonstrating true periodontal regeneration. The aim of this two-center prospective clinical study was to evaluate 2-year outcome of periodontal regenerative therapy using EMD in the treatment of intrabony defects, performed as an 'advanced medical treatment' under the national healthcare system in Japan. RESULTS: Patients with chronic periodontitis who have completed initial periodontal therapy at either of the two dental school clinics were enrolled...
July 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28680555/long-term-evaluations-of-teeth-and-dental-implants-during-dental-maintenance-period
#16
Da-Le Yoon, Yong-Gun Kim, Jin-Hyun Cho, Jae-Mok Lee, Sang-Kyu Lee
PURPOSE: This study was designed to evaluate the teeth and dental implants during dental maintenance therapy over 3 years in different conditions after periodontal and dental prosthetic treatment. MATERIALS AND METHODS: 166 patients received maintenance therapy. 59 patients were treated with 2% minocycline-HCl ointment as local drug delivery (LDD) (L group) and 107 patients were treated without LDD (NL group). Clinical data was collected in maintenance period for evaluation...
June 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28678975/antibiotic-therapy-as-an-adjunct-to-scaling-and-root-planing-in-smokers-a-systematic-review-and-meta-analysis
#17
Naida Zanini Assem, Márcio Luiz Ferro Alves, Alessandra Barreto Lopes, Erivan Clementino Gualberto, Valdir Gouveia Garcia, Letícia Helena Theodoro
The aim of this study was to perform a systematic review and meta-analysis to examine the effect of systemic antibiotics in the periodontal treatment of smokers. The selection criteria were as follows: controlled randomized clinical trials; studies published in English; studies with smoker patients diagnosed with chronic periodontitis; patients without systemic diseases; studies that used systemic antibiotic therapy associated with periodontal treatment; studies that presented results for the test and control groups and assessments of clinical periodontal parameters, such as probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL)...
July 3, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28678950/effect-of-1-sodium-alendronate-in-the-non-surgical-treatment-of-periodontal-intraosseous-defects-a-6-month-clinical-trial
#18
Bernardo Carvalho Dutra, Alcione Maria Soares Dutra Oliveira, Peterson Antônio Dutra Oliveira, Flavio Ricardo Manzi, Sheila Cavalca Cortelli, Luís Otávio de Miranda Cota, Fernando Oliveira Costa
Background and objectives: Few studies have evaluated the effect of the topical application of sodium alendronate (ALN) on the treatment of intrabuccal bone defects, especially those caused by periodontitis. This 6-month randomized placebo controlled clinical trial aimed at evaluating the effect of non-surgical periodontal treatment associated with the use of 1% ALN, through clinical evaluations and cone-beam computed tomography (CBCT). Material and Methods: Twenty individuals with chronic periodontitis underwent periodontal examination at the baseline as well as 3 and 6 months after periodontal treatment, registering clinical attachment level (CAL), periodontal probing depth (PPD), and bleeding on probing (BOP) as the clinical outcomes...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28678942/role-of-1-alendronate-gel-as-adjunct-to-mechanical-therapy-in-the-treatment-of-chronic-periodontitis-among-smokers
#19
Anuj Sharma, Achala Raman, Avani Raju Pradeep
Objective: Alendronate (ALN) inhibits osteoclastic bone resorption and triggers osteostimulative properties both in vivo and in vitro, as shown by increase in matrix formation. This study aimed to explore the efficacy of 1% ALN gel as local drug delivery (LDD) in adjunct to scaling and root planing (SRP) for the treatment of chronic periodontitis among smokers. Material and Methods: 75 intrabony defects were treated in 46 male smokers either with 1% ALN gel or placebo gel...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28677765/expression-and-antimicrobial-character-of-cells-transfected-with-human-%C3%AE-%C3%A2-defensin%C3%A2-3-against-periodontitis%C3%A2-associated-microbiota-in-vitro
#20
Minwen Zhu, Bo Miao, Jianhua Zhu, Haiyan Wang, Zengtong Zhou
Periodontitis is an oral chronic inflammatory disease induced by microorganisms that can destroy tooth‑supporting structures. Human β‑defensin‑3 (HBD‑3) is a type of endogenous antimicrobial peptide that inhibits a broad spectrum of microorganisms. The objectives of the present study were to transfect human periodontal ligament cells (HPDLCs) and human bone marrow stromal cells (HBMSCs) with lentivirus containing the HBD‑3 gene, determine the transfection efficiency, and investigate the antimicrobial activity of the experimental cells against periodontal pathogens...
July 4, 2017: Molecular Medicine Reports
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