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Periodontal therapy

F-Z Matos, A-M-F Aranha, Á-H Borges, F-L-M Pedro, S-A Raslan, F Hamida, K Veiga, A-N Porto
BACKGROUND: The aim of study was to evaluate the oral health status, salivary flow and halitosis among individuals diagnosed with leprosy as compared with healthy subjects. MATERIAL AND METHODS: A sample of 160 individuals was allocated into four groups, as follows: (G1) individuals with complete leprosy treatment; (G2) individuals diagnosed with leprosy and under multi-drug therapy; (G3) individuals diagnosed with leprosy not yet under treatment; and (G4) healthy individuals...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
T Ruggiero, R Pol, D Camisassa, S Simiele, L Giaccone, S Carossa
The purpose of the study is to evaluate the clinical effects of Mucosamin® (a spray preparation containing sodium hyaluronate combined with a pool of amino acids of precursor collagen, including L-Proline, L-Leucine, L-Lysine and glycine) on wound healing and pain management of oral mucositis after hematopoietic stem cell transplantation. The importance of professional dental hygiene by dental hygienist in reducing the severity of oral mucositis as unique therapy or in addition to therapy with Mucosamin® was also evaluated...
May 2018: Journal of Biological Regulators and Homeostatic Agents
A B Segarra, I Prieto, M Martinez-Canamero, F Vargas, M De Gasparo, P Vanderheyden, S Zorad, M Ramirez-Sanchez
Stem cells constitute a non-specialised cell pool able for proliferation, self-renewal and differentiation into progeny constantly replacing used up tissue and/or organ fragments. They have been observed to be present in many tissue reservoirs, including stomatognathic system. Oral cavity seems to be a particularly attractive stem cells' source as these cells are richly present and easily accessible in dental and periodontal tissues and they can be used for therapeutic purposes. Their application is also morally and ethically non-controversial...
April 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Sarah K Sonnenschein, Carlota Betzler, Rebecca Kohnen, Johannes Krisam, Ti-Sun Kim
OBJECTIVE: To assess the oral health-related quality of life (OH-QoL) in patients under supportive periodontal therapy (SPT) and the influence of the individual periodontal risk as well as different degrees of adherence during SPT on OH-QoL. MATERIALS AND METHODS: 309 patients with at least 5 years of SPT were re-examined. Periodontal risk profile (according to Lang and Tonetti) was assessed and the adherence to SPT-appointments within the last 30(±6) months was reviewed for each patient (fully adherent: adherence to all appointments ±6 weeks, partially adherent: SPT-interval not extended more than half of the recommended interval, insufficiently adherent: SPT-interval extended more than half of the recommended interval, non-adherent: recommended SPT-interval interruption ≥12 months)...
June 19, 2018: Acta Odontologica Scandinavica
Beatriz Hernández-Monjaraz, Edelmiro Santiago-Osorio, Edgar Ledesma-Martínez, Andrés Alcauter-Zavala, Víctor Manuel Mendoza-Núñez
Objective To report a case of successful allogeneic grafting of mesenchymal dental pulp stem cells (DPSCs) as preliminary findings in a patient with periodontal disease enrolled into clinical trial ISRCTN12831118. Methods Mesenchymal stem cells from the dental pulp of a deciduous tooth from a 7-year-old donor were separated from the pulp chamber and processed via enzymatic digestion and centrifugation. DPSCs were passaged and cultured on a 35 × 13 mm culture dish in minimum essential medium-alpha, without supplementation...
January 1, 2018: Journal of International Medical Research
István Gera
Data from epidemiological and clinical studies published in the past two decades indicate certain association between periodontal disease and increased risk for preterm birth or low birth weight. Although the strength of those observed associations is weak, periodontitis today is considered as one of the potentially modifiable risk factors for adverse pregnancy outcomes. The aims of the publication are to summarize the epidemiological and clinical evidence for the impact of periodontal disease on adverse pregnancy outcomes and to make an attempt to overview the potential biological mechanism behind this association...
June 2018: Orvosi Hetilap
Letizia Romeo, Francesca Diomede, Agnese Gugliandolo, Domenico Scionti, Fabrizio Lo Giudice, Veronica Lanza Cariccio, Renato Iori, Placido Bramanti, Oriana Trubiani, Emanuela Mazzon
The therapeutic strategies for neurodegenerative diseases still represent a vast research field because of the lack of targeted, effective and resolutive treatment for neurodegenerative diseases. The use of stem cell-based therapy is an alternative approach that could lead to the replacement of damaged neuronal tissue. For this purpose, adult mesenchymal stem cells (MSC), including periodontal ligament stem cells (PDLSCs), could be very useful for their differentiation capacity, easy isolation and the ability to perform an autologous implant...
June 14, 2018: Scientific Reports
Chinta Sumadhura, Jammula Surya Prasanna, Chinta Sindhura, Parupalli Karunakar
Context: : The influence of sex steroid hormones on periodontium can be lowered with good plaque control. Aims: The aim of the present study was to evaluate periodontal status in pre- and post-menopausal women with periodontitis following nonsurgical therapy. Settings and Design: Interventional pre-post clinical trial. Subjects and Methods: Periodontal status was measured by periodontal index (PRI), and oral hygiene status was measured by plaque index (PI)...
May 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
C N Guruprasad, A R Pradeep
Background: Interleukin-34 (IL-34) is a recently identified alternative ligand for colony-stimulating factor-1 receptor plays an important role in osteoclastogenesis. The aim of this study was to evaluate the IL-34 levels in gingival crevicular fluid (GCF) and plasma in subjects with chronic periodontitis and to evaluate the effect of nonsurgical periodontal therapy on the GCF and plasma IL-34 levels. Materials and Methods: Thirty individuals (age range: 30-56 years) were selected and divided into groups based on the gingival index, probing pocket depth, clinical attachment level, and radiologic parameters (bone loss): Group I (15 individuals with healthy periodontium), Group II (15 individuals with chronic generalized periodontitis) while Group II patients after 8 weeks of the treatment (scaling and root planning) constituted Group III...
May 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Y A Guzman, D Sakellari, K Papadimitriou, C A Floudas
BACKGROUND AND OBJECTIVE: Untargeted, high-throughput proteomics methodologies have great potential to aid in identifying biomarkers for the diagnosis of periodontal disease. The application of such methods to the discovery of candidate biomarkers for the resolution of periodontal inflammation after periodontal therapy has been investigated. MATERIAL AND METHODS: Gingival crevicular fluid samples were collected from 10 patients diagnosed with chronic periodontitis at baseline and 1, 5, 9 and 13 weeks after completion of mechanical periodontal treatment...
June 14, 2018: Journal of Periodontal Research
Vishnu Jayakumar Sunandhakumari, Arun Sadasivan, Elizabeth Koshi, Aswathy Krishna, Aneesh Alim, Aneesh Sebastian
For years the pathogenesis of periodontitis was under an immunological Th1/Th2 paradigm. Th1 cells are considered to afford protection against the intracellular pathogens. These cells produce the interferons (IFN) that are involved in macrophage activation, which, in turn, plays an important role in phagocytosis, complement fixation, and opsonization. Th2 cells are thought to have evolved as a form of protection against parasitic helminthes. Th17 subset of CD4Not Necessary+ T cells was identified in the year 2005, which added greater complexity to Th function and are pro inflammatory in nature...
June 13, 2018: Dentistry journal
Jardel Francisco Mazzi-Chaves, Igor Bassi Ferreira Petean, Isadora Mello Vilarinho Soares, Alessandro Guimarães Salles, Lívia Azeredo Alves Antunes, Raquel Assed Bezerra Segato, Léa Assed Bezerra da Silva, Erika Calvano Küchler, Leonardo Santos Antunes, Manoel Damião Sousa-Neto
Persistent apical periodontitis (AP) is a situation involving an inflammatory and immune response caused mainly by anaerobic polymicrobial infection of the root canal system and the outcome and follow-up of the root canal treatment has been reported as intimately related to host response. The apical periodontitis repair might be associated with genetic polymorphisms. This study aimed to evaluate the association between HIF1A genetic polymorphisms (rs2301113 and rs2057482) with PAP in Brazilian patients. Subjects with at least 1 year of follow-up after root canal therapy (RCT) were recalled...
March 2018: Brazilian Dental Journal
Rajan Gupta, Satwinder Kaur, Parveen Dahiya, Mukesh Kumar
The treatment of periodontitis primarily consists of mechanical debridement carried out by means of thorough scaling and root planing that might sometimes be a painful procedure which requires the administration of some form of local anesthesia. The present study comparatively evaluates the anesthetic effect of three such forms, viz; eutectic mixture of 25 mg/g lignocaine plus 25 mg/g prilocaine (EMLA) and needleless jet anesthesia during SRP. 30 patients with probing depth of 5 mm or more and visual analog scale (VAS) score of ≥30 mm on probing were selected and asked to assess the pain by VAS and verbal rating scale (VRS) during SRP after application of the two agents...
May 2018: Journal of Oral Biology and Craniofacial Research
Stuti Gupta, Shivjot Chhina, Sachit Anand Arora
The objective of the study was to conduct a systematic review of the literature so as to evaluate and summarize the diagnostic and prognostic potential of GCF. Included studies were systematically analyzed based on PRISMA (Preferred Reporting Items For Systematic Reviews and Meta Analyses) and studies were identified based on the-PICO (Glossary of evidence based terms 2007): 1)Patients with chronic periodontitis.2)Intervention- NSPT (Non-SurgicalPeriodontal therapy); NSPT + Chemotherapeutics.3)Comparison between treated v/s non treated sites...
May 2018: Journal of Oral Biology and Craniofacial Research
C-H Lee, Y-W Chen, Y-K Tu, Y-C Wu, P-C Chang
BACKGROUND AND OBJECTIVE: The response to nonsurgical periodontal treatment varied among patients. This study assessed the potential of salivary biomarkers for predicting the sensitivity and monitoring the response to nonsurgical periodontal therapy. MATERIAL AND METHODS: This study recruited 34 participants with severe chronic periodontitis (the test group) and 20 participants without periodontal destruction in any teeth (the control group) from September 6, 2013 to August 25, 2017...
June 7, 2018: Journal of Periodontal Research
Alexander E Tun, Leontine Benedicenti, Evelyn M Galban
Pasteurella multocida can cause meningoencephalomyelitis in canine patients with severe periodontal disease. Fever and neutrophilic pleocytosis in the cerebrospinal fluid are likely, and blood culture and/or empiric antibiotic therapy are indicated.
June 2018: Clinical Case Reports
Subash Chandra Raj, Subhashree Manaswini Panda, Muktikesh Dash, Kaushik Patnaik, Devapratim Mohanty, Neelima Katti, Annuroopa Mahapatra, Debasish Mishra, Kamdev Praharaj
Background: Innovating newer methods to diagnose a multifactorial disease such as periodontitis is always challenging for a clinician. Gingival crevicular fluid (GCF) which is closely associated with the periodontal tissue environment has been used a viable alternative to saliva for the diagnosis of periodontitis. Aim: The aim of the present study was to estimate and compare the interleukin-35 (IL-35) levels in GCF and serum among healthy, gingivitis, and chronic periodontitis (CP) individuals as well as to evaluate the effect of nonsurgical periodontal treatment (NSPT) on IL-35 level among patients with CP...
April 2018: Contemporary Clinical Dentistry
Jeffy Ann Jose, Sanju Somaiah, Sunil Muddaiah, Balakrishna Shetty, Goutham Reddy, S Roopa
Background and Objectives: Orthodontic forces are known to produce mechanical damage and inflammatory mediators such as prostaglandins (PGs) and interleukin (IL)-1, in the periodontium and dental pulp. Low-level laser therapy (LLLT) is a stimulator of the on-going biological process in tissue and found to be effective in modulating cell activity, which is involved in orthodontic tooth movement. Here, a humble effort has been made to study two such cytokines, namely IL-1 β and PG E2 (PGE2) which are partially responsible for bone turnover...
April 2018: Contemporary Clinical Dentistry
Bharathi Devi Jonnalagadda, Sruthima N V S Gottumukkala, C D Dwarakanath, Suneetha Koneru
Background and Objectives: Lasers have been widely used because of several potential benefits such as antibacterial effect and stimulation of wound healing. In addition, lasers help in hemostasis and delaying epithelial migration which may facilitate the outcome of flap surgery. Hence, this study is aimed to investigate the adjunctive effect of diode laser irradiation on conventional access flap surgery in the treatment of periodontal disease. Materials and Methods: A total of 23 patients requiring periodontal flap surgery in two sextants with probing pocket depth ≥5 mm in at least three teeth post-phase I therapy were selected for a split-mouth study...
April 2018: Contemporary Clinical Dentistry
Marco Aurelio L Saffi, Eneida R Rabelo-Silva, Carisi A Polanczyk, Mariana V Furtado, Marlon M Montenegro, Ingrid W J Ribeiro, Cassio Kampits, Cassiano K Rösing, Alex N Haas
OBJECTIVE: To assess the effects of periodontal treatment on endothelial function in patients with coronary artery disease. MATERIALS AND METHODS: A randomized controlled trial was conducted with 69 patients with stable coronary disease and severe periodontitis. The test group received non-surgical periodontal therapy consisting of personalized oral hygiene instructions, subgingival scaling and root planing per quadrant, whereas the control group received equal treatment after the study period...
June 6, 2018: Oral Diseases
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