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https://www.readbyqxmd.com/read/27912817/molecular-mechanisms-of-apical-periodontitis-emerging-role-of-epigenetic-regulators
#1
REVIEW
Shebli Mehrazarin, Abdullah Alshaikh, Mo K Kang
Conventional root canal therapies yield high success rates. The treatment outcomes are negatively affected by the presence of apical periodontitis (AP), which reflects active root canal infection and inflammatory responses. Also, cross-sectional studies revealed surprisingly high prevalence of AP in the general population, especially in those with prior endodontic treatments. Hence, AP is an ongoing disease entity in endodontics that needs further understanding of the pathogenesis and disease progression. The current Chapter will discuss the basic mechanisms of AP with emphasis on emerging role of epigenetic regulators in regulation of inflammatory mediators...
January 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/27912814/biological-molecules-for-the-regeneration-of-the-pulp-dentin-complex
#2
REVIEW
Sahng G Kim
Regenerative endodontic treatment has yielded excellent clinical outcomes, but only several animal studies have shown the robust regeneration of the pulp-dentin complex. The biological molecules, if properly delivered, can enkindle regeneration of dental pulp and dentin rather than repair with tissues of periodontal origin. This review details the biological significance of regenerating the pulp-dentin complex, the effects of biological cues in pulp regeneration, and the delivery strategies of biological molecules to enhance the outcomes of regenerative endodontic therapy...
January 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/27909894/antimicrobial-photodynamic-therapy-vs-local-minocycline-in-addition-to-non-surgical-therapy-of-deep-periodontal-pockets-a-controlled-randomized-clinical-trial
#3
Laura Tabenski, Daniel Moder, Fabian Cieplik, Frederike Schenke, Karl-Anton Hiller, Wolfgang Buchalla, Gottfried Schmalz, Michael Christgau
OBJECTIVES: To investigate the additional influence of either antimicrobial photodynamic therapy (aPDT; Helbo® Photodynamic Systems) or local application of minocycline microspheres (MC; Arestin, OraPharma) on clinical and microbiological healing results in deep periodontal pockets (PPD ≥6 mm) following non-surgical periodontal therapy (SRP). MATERIALS AND METHODS: Forty-five patients with chronic periodontitis were evaluated: test group aPDT + SRP (n = 15), positive control group MC + SRP (n = 15), and negative control group SRP-alone (n = 15)...
December 1, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27903250/effectiveness-of-bovine-derived-xenograft-versus-bioactive-glass-with-periodontally-accelerated-osteogenic-orthodontics-in-adults-a-randomized-controlled-clinical-trial
#4
Maha A Bahammam
BACKGROUND: Periodontally accelerated osteogenic orthodontics (PAOO) combines periodontal therapy with orthodontic therapy, which minimises treatment time. This study compared the effectiveness of a bovine-derived xenograft with that of bioactive glass when combined with PAOO for the treatment of adult patients with moderate crowding of the teeth. METHODS: In this prospective, single-masked clinical trial, 33 orthodontic patients (20 women, 13 men; mean age 21.2 ± 1...
November 30, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27901209/effect-of-resveratrol-on-periodontal-pathogens-during-experimental-periodontitis-in-rats
#5
Fabiano Ribeiro Cirano, Renato Correa Viana Casarin, Fernanda Vieira Ribeiro, Marcio Zaffalon Casati, Suzana Peres Pimentel, Tiago Taiete, Maria Martha Bernardi
The objective of this study was to investigate the antibacterial effect of resveratrol against putative periodontal pathogens during the progression of experimental periodontitis in rats. Periodontitis was induced in rats in one of the first molars chosen to receive a ligature. Animals were assigned to one of two groups: daily administration of the placebo solution (control group, n = 12) or 10 mg/Kg of resveratrol (RESV group, n = 12). The therapies were administered systemically for 30 days, for 19 days before periodontitis induction and then for another 11 days...
November 28, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27900246/siga-peroxidase-and-collagenase-in-saliva-of-smokers-aggressive-periodontal-patients
#6
Myriam A Koss, Cecilia E Castro, Agustina M Gramajo, María E López
BACKGROUND: Tobacco smoking is strongly associated with destructive periodontal disease, alveolar bone loss and poor response to periodontal therapy. The aim of this study was to investigate the effect of smoking on antimicrobials and destructive proteins in the saliva of patients with generalized aggressive periodontal disease. MATERIAL AND METHODS: The study group consisted of 55 adult subjects. They were classified according to their clinical diagnoses either as having generalized aggressive periodontitis (n = 27; 13 smokers and 14 non-smokers) or as periodontitis-free control group (n = 28; 14 smokers and 14 non-smokers)...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27893154/withdrawn-occlusal-interventions-for-periodontitis-in-adults
#7
REVIEW
Paul Weston, Yuhaniz A Yaziz, David R Moles, Ian Needleman
BACKGROUND: Occlusal interventions may be used in adults with periodontitis. At present there is little consensus regarding the indications and effectiveness of occlusal interventions in periodontal patients. OBJECTIVES: To identify and analyse the evidence for the effect of occlusal interventions on adults who have periodontitis in relation to tooth loss, probing depths, clinical attachment level, adverse effects and patient-centred outcomes. SEARCH METHODS: The search was last conducted in April 2008...
November 28, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27891455/unmasking-the-effect-of-analgesics-on-endodontic-diagnosis-using-a-novel-bite-force-sensor-device-a-prospective-randomized-clinical-trial
#8
Sushil Kishnani, Suparna Ganguly Saha, Anuj Bhardwaj, Sandeep Dubey, Mainak Saha, Shubham Kala, Sohini Jain, Shweta Narwani
INTRODUCTION: A definitive diagnosis is of primary importance before initiating any endodontic treatment; yet, there are occasions when the dental professional is unable to accurately reproduce the patient's chief complaint, as it can pose a dilemma and may require consideration of multiple variables in order to reach an accurate diagnosis. So to overcome this problem, a methodical approach in providing endodontic treatment should be implemented which includes diagnosis, definitive dental treatment and adjunctive drug therapy, known as the "3D" strategy...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891261/perioprosthetic-and-implant-supported-rehabilitation-of-complex-cases-clinical-management-and-timing-strategy
#9
Luca Landi, Stefano Piccinelli, Roberto Raia, Fabio Marinotti, Paolo Francesco Manicone
Treatment of complex perioprosthetic cases is one of the clinical challenges of everyday practice. Only a complete and thorough diagnostic setup may allow the clinician to formulate a realistic prognosis to select the abutments to support prosthetic rehabilitation. Clinical, radiographic, or laboratory parameters used separately are useless to correctly assign a reliable prognosis to single teeth except in the case of a clearly hopeless tooth. Therefore, it is crucial to gather the greatest quantity of data to determine the role that every single element can play in the prosthetic rehabilitation of the case...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27890003/biofilm-mediated-antibiotic-resistant-oral-bacterial
#10
Indu Lata Kanwar, Abhishek Kumar Sah, Preeti K Suresh
Oral diseases like dental caries and periodontal disease are directly associated with the capability of bacteria to form biofilm. Periodontal diseases have been associated to anaerobic Gram-negative bacteria forming a subgingival plaque (Porphyromonas gingivalis, Actinobacillus, Prevotella and Fusobacterium). Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. Biofilm communities are the causative agents of biological developments such as dental caries, periodontitis, and peri-implantitis, and causing periodontal tissue breakdown...
November 24, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27888165/clinical-effectiveness-of-adjunctive-antimicrobial-photodynamic-therapy-for-residual-pockets-during-supportive-periodontal-therapy-a-systematic-review-and-meta-analysis
#11
Dong Xue, Ying Zhao
PURPOSE: To evaluate the clinical efficacy of antimicrobial photodynamic therapy (aPDT) adjunctive to scaling and root planing (SRP) in the treatment of residual pockets for chronic periodontitis patients on supportive periodontal therapy (SPT). METHOD: Bibliographic databases of MEDLINE and Cochrane Library were thoroughly searched up to July 2016 for eligible randomized controlled trials (RCTs). Mean differences (MD) and the corresponding 95% confidence intervals (CI) were synthesized for probing depth (PD) reduction and clinical attachment level (CAL) gain...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27888163/antimicrobial-photodynamic-therapy-adjuvant-to-non-surgical-periodontal-therapy-in-patients-with-diabetes-mellitus-a-meta-analysis
#12
REVIEW
Tariq Abduljabbar, Fahim Vohra, Fawad Javed, Zohaib Akram
BACKGROUND: To determine whether treatment with antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) improves periodontal clinical and glycemic outcomes in chronic periodontitis patients (CP) with type 2 diabetes mellitus (DM). METHODS: Databases (MEDLINE via PubMed; EMBASE; Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases) were searched up to and including October 2016. The addressed PICO question was: "What are the effects aPDT as an adjunct to SRP in terms of periodontal and glycemic outcomes as compared to SRP alone in individuals with DM?" RESULTS: Four randomized clinical trials were included in the present review...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27883212/a-retrospective-study-on-periodontal-disease-progression-in-private-practice
#13
Luigi Nibali, Chuanming Sun, Aliye Akcalı, Xsuan Meng, Yu-Kang Tu, Nikos Donos
BACKGROUND: Only a handful of studies have assessed tooth loss risk in chronic periodontitis patients following active therapy and factors associated with it. AIMS: The aim of this retrospective study was to assess tooth loss in a cohort of chronic periodontitis patients undergoing maintenance care in a UK private practice setting. MATERIALS AND METHODS: One hundred chronic periodontitis patients treated with active periodontal therapy (APT) were followed up in supportive periodontal therapy (SPT) for at least 5 years...
November 24, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27883202/the-role-of-platelets-in-inflammatory-immune-responses-in-generalized-aggressive-periodontitis
#14
Yalin Zhan, Ruifang Lu, Huanxin Meng, Xian'e Wang, Xiaojun Sun, Jianxia Hou
AIM: To investigate the relationship between inflammatory markers and platelet size in generalized aggressive periodontitis (GAgP). MATERIAL AND METHODS: Periodontal, inflammatory, and platelet indices were compared between 59 GAgP patients and 59 healthy subjects. Gingival biopsies from 5 patients and 5 healthy subjects were examined by immunohistochemistry and electron microscopy. Changes in patient periodontal and platelet indices were re-evaluated at 3 months after periodontal therapy...
November 24, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27871617/management-of-cannabis-induced-periodontitis-via-resective-surgical-therapy-a-clinical-report
#15
Fatemeh Momen-Heravi, Philip Kang
BACKGROUND AND OVERVIEW: There is a lack of clinical research on the potential effect of cannabis use on the periodontium as well as its effect on treatment outcomes. The aim of this case report is to illustrate the clinical presentation of periodontal disease in a young woman who was a chronic cannabis user, as well as successful treatment involving motivating the patient to quit cannabis use and undergo nonsurgical and surgical therapy. CASE DESCRIPTION: A 23-year-old woman sought care at the dental clinic for periodontal treatment...
November 18, 2016: Journal of the American Dental Association
https://www.readbyqxmd.com/read/27868202/the-potential-risks-of-orthodontic-therapy-a-critical-review-and-conceptual-framework
#16
REVIEW
Morgan Wishney
The review examines some of the potential risks of orthodontic therapy along with their evidence base. The risks of orthodontic treatment include periodontal damage, pain, root resorption, tooth devitalisation, temporomandibular disorder, caries, speech problems and enamel damage. These risks can be understood to arise from a synergy between treatment and patient factors. In general terms, treatment factors that can influence risk include appliance type, force vectors and duration of treatment whilst relevant patient factors are both biological and behavioral...
November 21, 2016: Australian Dental Journal
https://www.readbyqxmd.com/read/27861820/periodontal-disease-and-the-metabolic-syndrome
#17
REVIEW
Ira B Lamster, Michael Pagan
The metabolic syndrome (MetS) is a spectrum of conditions that increase the risk of cardiovascular disease and diabetes mellitus. The components of MetS include dysglycemia, visceral obesity, atherogenic dyslipidemia (elevated triglycerides and low levels of high-density lipoprotein) and hypertension. An association of periodontal disease and MetS has been suggested. This association is believed to be the result of systemic oxidative stress and an exuberant inflammatory response. When examined individually, the components of the MetS that are most closely related to the risk of periodontitis are dysglycemia and obesity, with lesser contributions by atherogenic dyslipidemia and hypertension...
November 9, 2016: International Dental Journal
https://www.readbyqxmd.com/read/27860247/preservation-of-root-cementum-a-comparative-evaluation-of-power-driven-versus-hand-instruments
#18
E Bozbay, F Dominici, A Y Gokbuget, S Cintan, L Guida, M S Aydin, A Mariotti, A Pilloni
OBJECTIVES: The purpose of this study was to evaluate the effects of three distinct periodontal treatment methods in comparison with hand instrumentation on residual cementum of periodontal diseased teeth. Cementum can influence the activities of periodontal cells and may play an important regulatory role in periodontal treatment. The ideal method for periodontal therapy involves removal of biofilm, calculus and endotoxin while preserving root cementum. MATERIAL AND METHODS: Forty-eight caries free, single-rooted teeth in patients diagnosed with severe chronic periodontitis were treated using four different methods prior to extraction...
November 16, 2016: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/27858072/-analysis-of-minocycline-hydrochloride-combined-with-vitapex-in-treating-senile-chronic-periodontal-endodontic-combined-lesions
#19
Zhen-Yu Liu, Jing-Dong Zhang, Lin Zhang, Jian Yang, Xiang-Hui Liu
PURPOSE: To investigate the effect of minocycline hydrochloride combined with Vitapex in treating senile chronic periodontal-endodontic combined lesions. METHODS: One hundred twenty patients with senile chronic periodontitis and endodontic lesions patients treated in our hospital between Jun.2012 to Jun.2014 were selected. They were divided into experimental group (n=60) and control group (n=60). Patients in the control group were given conventional root canal therapy, while patients in the experimental group were given Vitapex and minocycline hydrochloride...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27857093/rheumatoid-arthritis-an-update-for-general-dental-practitioners
#20
S de Souza, R K Bansal, J Galloway
Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disorder which significantly impacts patients' lives and can lead to permanent disability. Inflammation in RA not only affects joints; but can affect organs including the heart and lungs. Early diagnosis, initiation of intensive drug therapy, and a multidisciplinary care approach have vastly improved the long-term prognosis for those living with the condition. However, RA patients often present with co-morbidities which add to the complexity of clinical management...
November 18, 2016: British Dental Journal
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