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https://www.readbyqxmd.com/read/28822764/effect-of-nitric-oxide-releasing-derivative-of-indomethacin-on-prevotella-intermedia-lipopolysaccharide-induced-production-of-proinflammatory-mediators-in-murine-macrophages
#1
So-Hui Choe, Eun-Young Choi, Jin-Yi Hyeon, In Soon Choi, Sung-Jo Kim
The purpose of this study was to investigate the influences of NCX 2121, a nitric oxide (NO)-releasing derivative of indomethacin, upon the generation of proinflammatory mediators using murine macrophages activated by lipopolysaccharide (LPS) isolated from Prevotella intermedia, which is one of the pathogens implicated in periodontal diseases. Inducible NO synthase (iNOS)-derived NO, IL-1β and IL-6 as well as their relevant mRNA were significantly attenuated by NCX 2121 in RAW264.7 cells activated by P. intermedia LPS...
August 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28822567/classification-and-clinical-management-of-retrograde-peri-implantitis-associated-with-apical-periodontitis-a-proposed-classification-system-and-case-report
#2
Nima D Sarmast, Howard H Wang, Ali S Sajadi, Nikola Angelov, Samuel O Dorn
Biological complications involving dental implants include peri-implant diseases such as peri-implant mucositis and peri-implantitis. The latter presents with progressive bone loss from the alveolar crest in a coronal apical direction. However, a separate disease entity termed retrograde peri-implantitis (RPI), which presents with progressive bone loss at the periapex of the implant, also exists and may be of particular interest to endodontists because it typically presents with periapical pathology of both the implant and adjacent tooth or at a site that previously housed an endodontically treated tooth...
August 16, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28820323/non-surgical-model-for-alveolar-bone-regeneration-by-bone-morphogenetic-protein-2-7-gene-therapy
#3
Mariko Kawai, Yo-Hei Kataoka, Junya Sonobe, Hiromitsu Yamamoto, Masakazu Inubushi, Takuya Ishimoto, Takayoshi Nakano, Hiroki Maruyama, Jun-Ichi Miyazaki, Toshio Yamamoto, Kazuhisa Bessho, Kiyoshi Ohura
BACKGROUND: Alveolar bone is a critical tissue for tooth retention; however, once alveolar bone is lost, it may not spontaneously regenerate. Currently, bone grafts or artificial bone are commonly used for alveolar bone regeneration therapy. However, these therapies require surgical procedures, which present risks, particularly in aged patients. Therefore, the development of alveolar bone regeneration techniques that do not require surgical procedures is critical. It is well known that stem cells present in the periosteal and periodontal ligament may be induced to differentiate into osteogenic cells...
August 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28820321/non-surgical-therapy-reduces-presence-of-jp2-clone-in-localized-aggressive-periodontitis
#4
Danielle K Burgess, Hong Huang, Peter Harrison, Theodora Kompotiati, Ikramuddin Aukhil, Luciana M Shaddox
BACKGROUND: Previous studies have provided substantial evidence on the association of Aggregatibacter actinomycetemcomitans (Aa), and its highly leukotoxic JP2 genotype, with localized aggressive periodontitis (LAP). The present study aims to evaluate the presence of JP2 in LAP individuals following periodontal treatment. METHODS: Sixty African American LAP patients between ages 5 and 25 years were examined. At baseline, pocket depth (PD), clinical attachment level (CAL), bleeding on probing (BoP) and plaque index were measured and subgingival plaque was collected from both LAP diseased sites and healthy sites for each participant...
August 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28817127/ten-year-nonsurgical-periodontal-treatment-protocol-with-adjunctive-use-of-diode-laser-monitoring-clinical-outcomes-in-%C3%A2-6-mm-pockets-a-retrospective-controlled-case-series
#5
Marisa Roncati, Annalisa Roncati, Cinzia Barbieri, Paolo Vescovi
The clinical effects of treatment with 808- and 980-nm diode lasers as an adjunct to a uniform and consistent nonsurgical periodontal treatment protocol (NSPTP) for initial probing pockets ≥ 6 mm with a 10-year follow-up were evaluated. In total, 24 patients (16 test cases and 8 control cases) were treated with the NSPTP. The control group (CG) was treated only with nonsurgical conventional therapy, while the test group (TG) received treatment with thermal diode lasers (wavelength of 808 or 980 nm). All patients had recall visits every 3 months and were reevaluated at 1 year after NSPTP...
September 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28816300/-combination-of-periodontal-orthodontic-and-endodontic-therapy-in-upper-anterior-teeth-with-hopeless-prognosis-and-long-time-follow-up-a-case-report
#6
Y Li, L Xu, Y H Zhou, X Y Ouyang, T Cao
It is complicated to decide the treatment plan of hopeless anterior teeth in esthetic zone due to severe periodontitis, periodontal-endodontic combined lesion or teeth trauma. The optional treatment plan for this kind of teeth includes retention after periodontal treatment, extraction and implant treatment, extraction and prosthodontic treatment and so on. To make an appropriate treatment plan, patients' periodontal conditions, periodontal biotype, local anatomy, esthetic demand, economic condition and social psychological status should be comprehensively considered...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28815256/-comparison-of-the-differences-in-pain-and-the-effect-of-ibuprofen-in-reducing-endodontic-flare-up-after-single-visit-root-canal-therapy-between-uyghur-and-han-patients-with-chronic-apical-periodontitis
#7
Lei Yan, Xin-Ying Wang, Na Wan, Pei-Ling Wu
PURPOSE: To compare the incidence of postoperative pain of chronic periapical periodontitis patients with root canal therapy between Han and Uygur, and the effect of ibuprofen in reducing endodontic flare-up after single-visit root canal therapy between Uyghur and Han patients with chronic apical periodontitis, in order to provide a basis for clinical administration. METHODS: Two hundred and fifty Uyghur and 250 Han patients with chronic apical periodontitis in their incisor, canine and premolar were collected, and randomly divided into 2 groups: experimental group and control group...
April 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28805207/periodontal-diseases
#8
REVIEW
Denis F Kinane, Panagiota G Stathopoulou, Panos N Papapanou
Periodontal diseases comprise a wide range of inflammatory conditions that affect the supporting structures of the teeth (the gingiva, bone and periodontal ligament), which could lead to tooth loss and contribute to systemic inflammation. Chronic periodontitis predominantly affects adults, but aggressive periodontitis may occasionally occur in children. Periodontal disease initiation and propagation is through a dysbiosis of the commensal oral microbiota (dental plaque), which then interacts with the immune defences of the host, leading to inflammation and disease...
June 22, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28804997/does-dental-hygienist-professional-education-meet-the-needs-of-working-life-educators-views
#9
T-L Jokiaho, P Kaakinen, J I Virtanen
OBJECTIVE: The aim of this study was to describe the compatibility of dental hygienist education with working life from the perspective of their educators. METHODS: We conducted a qualitative study among principal educators of dental hygienists in Finland in 2012-2013. The participants were leading educators of dental hygienists (n = 13) from the four Finnish education units. We used semi-structured interviews based on previous Nordic studies to collect the data and analysed them using inductive content analysis...
August 14, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28803745/further-development-of-the-mronj-minipig-large-animal-model
#10
Sven Otto, Christoph Pautke, Olga Martin Jurado, Dirk Nehrbass, Martin J Stoddart, Michael Ehrenfeld, Stephan Zeiter
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious and potentially severe side effect of antiresorptive therapy with bisphosphonates or denosumab. Recently, a large animal minipig MRONJ model was introduced which led to early necrotic lesions in the majority of extraction sites after bisphosphonate administration. The aim of this project was to modify the preoperative cumulative bisphosphonate dose (zoledronate) and hereby firstly to demonstrate the reliability and reproducibility of the established model...
July 18, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28800151/cost-comparison-of-prediction-based-decision-making-for-periodontally-affected-molars
#11
Falk Schwendicke, Michael Stolpe, Christian Graetz
AIM: Tooth loss prediction could improve decision-making for periodontally-affected molars. We analyzed the costs of removing all, none or only those molars predicted to be at-risk for extraction during supportive periodontal therapy (SPT). METHODS: This is a model-based study using a German private-payer-perspective. Building mainly on cost and effectiveness data from 2039 molars (301 patients) which received long-term SPT, five (exemplary) prediction/decision strategies were compared: Retaining all molars, removing molars with furcation-involvement (FI) ≥I/≥II/III, or removing all molars...
August 11, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28796888/a-double-masked-rct-comparing-four-periodontitis-treatment-strategies-5-year-clinical-results
#12
Hans R Preus, Per Gjermo, Vibeke Baelum
AIM: To test the hypothesis of no difference in the 5-year clinical outcome of therapy between groups of patients treated with conventional over-weeks scaling and root planing or same-day full-mouth-disinfection, with or without adjunctive metronidazole. MATERIALS AND METHODS: Following a three-month oral hygiene phase, 184 periodontitis patients were randomly allocated to one of four treatment regimens 1) full mouth disinfection+metronidazole, 2) full mouth disinfection+placebo, 3) scaling and root planing+metronidazole, 4) scaling and root planing+placebo...
August 10, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28774432/automatic-methods-for-alveolar-bone-loss-degree-measurement-in-periodontitis-periapical-radiographs
#13
P L Lin, P Y Huang, P W Huang
BACKGROUND AND OBJECTIVE: Periodontitis involves progressive loss of alveolar bone around the teeth. Hence, automatic alveolar bone loss measurement in periapical radiographs can assist dentists in diagnosing such disease. In this paper, we propose an automatic length-based alveolar bone loss measurement system with emphasis on a cementoenamel junction (CEJ) localization method: CEJ_LG. METHOD: The bone loss measurement system first adopts the methods TSLS and ABLifBm, which we presented previously, to extract teeth contours and bone loss areas from periodontitis radiograph images...
September 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28772932/cerium-chloride-application-promotes-wound-healing-and-cell-proliferation-in-human-foreskin-fibroblasts
#14
Liza L Ramenzoni, Franz E Weber, Thomas Attin, Patrick R Schmidlin
This study investigated the effect of cerium chloride (CeCl₃) on cell migration and gene expression of human foreskin fibroblasts (HFF). HFF were exposed to three different CeCl₃ solutions (1%, 5% and 10%, w/v %) for three different time durations (1, 5 and 10 min). 72 h after exposure to CeCl₃, cell viability was assessed by MTT test. A scratch-wounded assay determined the cell migration and the width of the wound, measured at 24 h. Gene expression patterns for cyclins B1, D1 and E1 were analyzed by RT-PCR (p < 0...
May 24, 2017: Materials
https://www.readbyqxmd.com/read/28768511/german-dentists-websites-on-periodontitis-have-low-quality-of-information
#15
Falk Schwendicke, Jörg Stange, Claudia Stange, Christian Graetz
BACKGROUND: The internet is an increasingly relevant source of health information. We aimed to assess the quality of German dentists' websites on periodontitis, hypothesizing that it was significantly associated with a number of practice-specific parameters. METHODS: We searched four electronic search engines and included pages which were freely accessible, posted by a dental practice in Germany, and mentioned periodontal disease/therapy. Websites were assessed for (1) technical and functional aspects, (2) generic quality and risk of bias, (3) disease-specific information...
August 2, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28767915/evaluation-of-periodontal-condition-and-risk-in-patients-with-chronic-kidney-disease-on-hemodialysis
#16
Yeon Jung Kim, Luciana Martins de Moura, Christiane Peres Caldas, Caroline Perozini, Gilson Fernandes Ruivo, Debora Pallos
Objective: To establish a profile of periodontal conditions in chronic kidney disease patients on hemodialysis and their periodontal risk. Methods: We included 115 patients on hemodialysis. Clinical periodontal parameters assessed were: plaque index, gingival index, probing depth and clinical attachment level. Patients were classified according to presence/absence and severity of periodontal disease and periodontal risk. Results: In 107 dentate patients (93%) the plaque index was 1...
April 2017: Einstein
https://www.readbyqxmd.com/read/28761379/effects-of-nonsurgical-periodontal-therapy-in-patients-with-moderately-controlled-type-2-diabetes-mellitus-and-chronic-periodontitis-in-nepalese-population
#17
Khushboo Goel, Shaili Pradhan, Madhur Dev Bhattarai
OBJECTIVES: Despite several investigations, evidence is still controversial regarding the effect of periodontal treatment on diabetes. This study evaluates and compares the effect on glycemic control and periodontal status with or without nonsurgical periodontal therapy in patients with type 2 diabetes mellitus and chronic periodontitis in a Nepalese population. MATERIALS AND METHODS: A total of 82 patients attending the diabetes clinic and fulfilling enrollment criteria with moderate to severe periodontitis were selected...
2017: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/28758304/subgingival-debridement-end-point-methods-and-how-often
#18
REVIEW
Isabelle Laleman, Simone Cortellini, Senne De Winter, Esteban Rodriguez Herrero, Christel Dekeyser, Marc Quirynen, Wim Teughels
Subgingival debridement is the part of nonsurgical therapy which aims to remove the biofilm without intentionally removing the cementum or subgingival calculus. The objective of this review was to describe the end point of this therapy, the different methods used and how often it should be carried out. The literature shows that several methods are currently available for subgingival debridement, namely hand instrumentation, (ultra)sonic instrumentation, laser, photodynamic therapy and air-polishing. None of these methods seems superior to any other regarding clinical benefits or microbiological differences...
October 2017: Periodontology 2000
https://www.readbyqxmd.com/read/28758297/what-exactly-distinguishes-aggressive-from-chronic-periodontitis-is-it-mainly-a-difference-in-the-degree-of-bacterial-invasiveness
#19
REVIEW
Ubele Van der Velden
At the International Workshop for Classification of Periodontal Diseases and Conditions in 1999, the classification of aggressive and chronic periodontitis that is presently used was introduced. A literature review of papers published in 2015 and having aggressive periodontitis in the title revealed that most studies use this terminology but it is questionable whether all established criteria were really applied correctly. Review of the literature showed no qualitative differences between aggressive and chronic periodontitis regarding bacterial and viral aspects...
October 2017: Periodontology 2000
https://www.readbyqxmd.com/read/28758295/lasers-and-the-treatment-of-periodontitis-the-essence-and-the-noise
#20
REVIEW
Charles M Cobb
The dental literature contains 25 years of accumulated reports and clinical studies addressing the utility of lasers in the treatment of periodontitis, both as a monotherapy or as an adjunct to surgical and nonsurgical therapy. Yet, the evidence from the 118 human clinical studies cited in this narrative review remains conflicted and insufficient to suggest that integration of a laser in a periodontal treatment protocol will provide antimicrobial and healing outcomes superior to those achieved by traditional therapy...
October 2017: Periodontology 2000
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