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https://www.readbyqxmd.com/read/28106247/validation-of-the-nccn-ipi-for-diffuse-large-b-cell-lymphoma-dlbcl-the-addition-of-%C3%AE-2-microglobulin-yields-a-more-accurate-geltamo-ipi
#1
Carlos Montalbán, Antonio Díaz-López, Ivan Dlouhy, Jordina Rovira, Armando Lopez-Guillermo, Sara Alonso, Alejandro Martín, Juan M Sancho, Olga García, Jose M Sánchez, Mario Rodríguez, Silvana Novelli, Antonio Salar, Antonio Gutiérrez, Maria J Rodríguez-Salazar, Mariana Bastos, Juan F Domínguez, Rubén Fernández, Sonia Gonzalez de Villambrosia, José A Queizan, Raul Córdoba, Raquel de Oña, Andrés López-Hernandez, Julian M Freue, Heidys Garrote, Lourdes López, Ana M Martin-Moreno, Jose Rodriguez, Víctor Abraira, Juan F García
The study included 1848 diffuse large B-cell lymphoma (DLBCL)patients treated with chemotherapy/rituximab. The aims were to validate the National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI) and explore the effect of adding high Beta-2 microglobulin (β2M), primary extranodal presentation and intense treatment to the NCCN-IPI variables in order to develop an improved index. Comparing survival curves, NCCN-IPI discriminated better than IPI, separating four risk groups with 5-year overall survival rates of 93%, 83%, 67% and 49%, but failing to identify a true high-risk population...
January 20, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28104808/training-mid-career-internists-to-perform-high-quality-colonoscopy-a-pilot-training-programme-to-meet-increasing-demands-for-colonoscopy
#2
Nicole K Shah-Ghassemzadeh, Christian S Jackson, David Juma, Richard M Strong
BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer deaths in the USA. Despite a recent rise in CRC screening there remains an increasing demand for colonoscopy, yet a limited supply of gastroenterologists who can meet this need. OBJECTIVE: To determine if a mid-career general internist (GIN) could be trained to perform high-quality colonoscopes via an intensive training programme. DESIGN: A GIN trained 2-3 days/week, 4-5 hours/day, for 7 months with an experienced gastroenterologist...
January 19, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28102113/comparison-of-the-effects-on-dynamic-balance-and-aerobic-capacity-between-objective-and-subjective-methods-of-high-intensity-robot-assisted-gait-training-in-chronic-stroke-patients-a-randomized-controlled-trial
#3
Young-Hyeon Bae, Suck Min Lee, Mansoo Ko
BACKGROUND: Robot-assisted gait training (RAGT) is effective for improving dynamic balance and aerobic capacity, but previous RAGT method does not set suitable training intensity. Recently, high-intensity treadmill gait training at 70% of heart rate reserve (HRR) was used for improving aerobic capacity and dynamic balance. PURPOSE: This study was designed to compare the effectiveness between objective and subjective methods of high-intensity RAGT for improving dynamic balance and aerobic capacity in chronic stroke...
January 19, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28100032/sequential-learning-during-contextual-fear-conditioning-guides-the-rate-of-systems-consolidation-implications-for-consolidation-of-multiple-memory-traces
#4
Lizeth K Pedraza, Rodrigo O Sierra, Ana P Crestani, Jorge A Quillfeldt, Lucas de Oliveira Alvares
Systems consolidation has been described as a time-dependent reorganization process involving the neocortical and hippocampal networks underlying memory storage and retrieval. Previous studies of our lab were able to demonstrate that systems consolidation is a dynamic process, rather than a merely passive, time-dependent phenomenon. Here, we studied the influence of sequential learning in contextual fear conditioning (CFC) with different training intensities in the time-course of hippocampal dependency and contextual specificity...
January 18, 2017: Hippocampus
https://www.readbyqxmd.com/read/28099398/utilizing-a-novel-mobile-health-selfie-application-to-improve-compliance-to-iron-chelation-in-pediatric-patients-receiving-chronic-transfusions
#5
Sarah Leonard, Lindsay M Anderson, Jude Jonassaint, Charles Jonassaint, Nirmish Shah
Iron chelation therapy can prevent iron overload for pediatric patients with sickle cell disease and β-thalassemia major; however, adherence is suboptimal. Therefore, we developed an intensive training program (ITP), to improve medication management and disease knowledge. The objectives were to determine feasibility of the ITP and its preliminary impact on adherence, disease knowledge, and health outcomes. Pediatric patients were recruited to participate in the ITP over a 90-day period and were followed for 6 months...
January 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28097842/in-hospital-capacity-building-in-research-and-management-for-pediatric-professionals
#6
Graciela Demirdjian, Susana Rodríguez, Juan C Vassallo, Vilma Irazola, Josefa Rodríguez
We describe an educational strategy aimed at capacity-building of hospital health care professionals in research and management initiated at a pediatric hospital in 2006, and the results obtained eight years after its implementation. Research and Management in Pediatrics (GIP) is an annual 250-hour course combining meetings and off-site assignments delivered through the Hospital's on-line campus. It provides students with practical tools for research (epidemiology, methodology, bibliographic search, evidencebased medicine, biostatistics) and management (strategic planning, management programs, health services research, quality improvement, health economics)...
1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28096648/identification-of-genetic-and-epigenetic-variants-associated-with-breast-cancer-prognosis-by-integrative-bioinformatics-analysis
#7
Arunima Shilpi, Yingtao Bi, Segun Jung, Samir K Patra, Ramana V Davuluri
INTRODUCTION: Breast cancer being a multifaceted disease constitutes a wide spectrum of histological and molecular variability in tumors. However, the task for the identification of these variances is complicated by the interplay between inherited genetic and epigenetic aberrations. Therefore, this study provides an extrapolate outlook to the sinister partnership between DNA methylation and single-nucleotide polymorphisms (SNPs) in relevance to the identification of prognostic markers in breast cancer...
2017: Cancer Informatics
https://www.readbyqxmd.com/read/28095952/neck-and-shoulder-muscle-activation-among-experienced-and-inexperienced-pilots-in-gz-exposure
#8
Tuomas Honkanen, Juha Oksa, Matti J Mäntysaari, Heikki Kyröläinen, Janne Avela
BACKGROUND: The aim of the present study was to compare differences in electromyography (EMG) activation of the neck and shoulder muscles between groups of inexperienced and experienced pilots during controlled +Gz exposure in a centrifuge. METHODS: The subjects were volunteer cadets (inexperienced group) and lieutenants (experienced group) undergoing their first centrifuge training. The first group did not have any high performance aircraft (HPA) experience, while the latter one had a 1-yr experience of intense flying of HPA...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28095070/player-responses-to-match-and-training-demands-during-an-intensified-fixture-schedule-in-professional-rugby-league-a-case-study
#9
Craig Twist, Jamie Highton, Matthew Daniels, Nathan Mill, Graeme Close
Player loads and fatigue responses were reported in 15 professional rugby league players (24.3 ± 3.8 y) during a period of intensified fixtures. Repeated measures of internal and external loads, perceived wellbeing and jump flight time were recorded across 22 days, comprising nine training sessions and matches on days 5, 12, 15 and 21 (player exposure: 3.6 ± 0.6 matches). Mean training load (session RPE x duration) between matches was 1177, 1083, 103, and 650 AU, respectively. Relative distance in Match 1 (82 m/min) and Match 4 (79 m/min) was very likely lower in Match 2 (76 m/min) and likely higher in Match 3 (86 m/min)...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28095069/the-evolution-of-champion-cross-country-skier-training-from-lumberjacks-to-professional-athletes
#10
Øyvind Sandbakk
Competitive cross-country (XC) skiing has traditions extending back to the mid-19th century, and was included as a men's event in the first Winter Games in 1924. Since then, tremendous improvements in equipment, track preparation, and knowledge about training have prompted greater increases in XC skiing speeds than in any other Olympic sport. In response, this commentary focuses on how the training of successful XC skiers has evolved, with interviews and training data from surviving Norwegian world and Olympic XC champions as primary sources...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28094408/large-area-tungsten-disulfide-for-ultrafast-photonics
#11
Peiguang Yan, Hao Chen, Jinde Yin, Zihan Xu, Jiarong Li, Zike Jiang, Wenfei Zhang, Jinzhang Wang, Irene Ling Li, Zhipei Sun, Shuangchen Ruan
Two-dimensional (2D) layered transition metal dichalcogenides (TMDs) have attracted significant interest in various optoelectronic applications due to their excellent nonlinear optical properties. One of the most important applications of TMDs is to be employed as an extraordinary optical modulation material (e.g., the saturable absorber (SA)) in ultrafast photonics. The main challenge arises while embedding TMDs into fiber laser systems to generate ultrafast pulse trains and thus constraints their practical applications...
January 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28093194/effects-of-neuromuscular-electrical-stimulation-during-hemodialysis-on-peripheral-muscle-strength-and-exercise-capacity-a-randomized-clinical-trial
#12
Ana Karla Vieira Brüggemann, Carolina Luana Mello, Tarcila Dal Pont, Deborah de Camargo Hizume Kunzler, Daniel Fernandes Martins, Franciane Bobinski, Wellington Pereira Yamaguti, Elaine Paulin
OBJECTIVE: To evaluate the effects of neuromuscular electrical stimulation of high and low frequency and intensity, performed during hemodialysis (HD), on physical function and inflammation markers in patients with chronic kidney disease (CKD). DESIGN: Randomized clinical trial SETTING: Hemodialysis clinic. PARTICIPANTS: 51 CKD patients were randomized into blocks of four by means of opaque envelopes. They were divided into a group of high frequency and intensity neuromuscular electrical stimulation (HG) and a group of low frequency and intensity neuromuscular electrical stimulation (LG)...
January 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28090600/learning-based-3t-brain-mri-segmentation-with-guidance-from-7t-mri-labeling
#13
Renping Yu, Minghui Deng, Pew-Thian Yap, Zhihui Wei, Li Wang, Dinggang Shen
Brain magnetic resonance image segmentation is one of the most important tasks in medical image analysis and has considerable importance to the effective use of medical imagery in clinical and surgical setting. In particular, the tissue segmentation of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is crucial for brain measurement and disease diagnosis. A variety of studies have shown that the learning-based techniques are efficient and effective in brain tissue segmentation. However, the learning-based segmentation methods depend largely on the availability of good training labels...
October 2016: Machine Learning in Medical Imaging
https://www.readbyqxmd.com/read/28089898/exercise-guidelines-to-promote-cardiometabolic-health-in-spinal-cord-injured-humans-time-to-raise-the-intensity
#14
Tom E Nightingale, Richard S Metcalfe, Niels Bj Vollaard, James L J Bilzon
Spinal cord injury (SCI) is a life changing event that, as a result of paralysis, negatively influences habitual levels of physical activity and hence cardiometabolic health. Performing regular structured exercise therefore appears extremely important in persons with SCI. However, exercise options are mainly limited to the upper-body, which involves a smaller activated muscle mass compared to the mainly leg-based activities commonly performed by non-disabled individuals. Current exercise guidelines for SCI focus predominantly on relative short durations of moderate-intensity aerobic arm cranking exercise, yet contemporary evidence suggests this is not sufficient to induce meaningful improvements in risk factors for the prevention of cardiometabolic disease in this population...
January 12, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28089456/protective-effects-of-exercise-training-on-endothelial-dysfunction-induced-by-total-sleep-deprivation-in-healthy-subjects
#15
Fabien Sauvet, Pierrick J Arnal, Pierre Emmanuel Tardo-Dino, Catherine Drogou, Pascal Van Beers, Clément Bougard, Arnaud Rabat, Garance Dispersyn, Alexandra Malgoyre, Damien Leger, Danielle Gomez-Merino, Mounir Chennaoui
BACKGROUND: Sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction. AIMS: To determine if 7weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men. METHODS: 16 subjects were examined during 40-h TSD, both before and after 7weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) and pulse wave velocity (PWV), blood pressure and heart rate (HR) were assessed before TSD (controlday), during TSD, and after one night of sleep recovery...
January 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28081223/high-intensity-jump-training-is-tolerated-during-60-days-of-bed-rest-and-is-very-effective-in-preserving-leg-power-and-lean-body-mass-an-overview-of-the-cologne-rsl-study
#16
Andreas Kramer, Jakob Kümmel, Edwin Mulder, Albert Gollhofer, Petra Frings-Meuthen, Markus Gruber
PURPOSE: Space agencies are looking for effective and efficient countermeasures for the degrading effects of weightlessness on the human body. The aim of this study was to assess the effects of a novel jump exercise countermeasure during bed rest on vitals, body mass, body composition, and jump performance. METHODS: 23 male participants (29±6 years, 181±6 cm, 77±7 kg) were confined to a bed rest facility for 90 days: a 15-day ambulatory measurement phase, a 60-day six-degree head-down-tilt bed rest phase (HDT), and a 15-day ambulatory recovery phase...
2017: PloS One
https://www.readbyqxmd.com/read/28081033/performance-aspects-and-physiological-responses-in-male-amateur-boxing-competitions-a-brief-review
#17
Maamer Slimani, Helmi Chaabène, Philip Davis, Emerson Franchini, Karim Chamari
Boxing is one of the most popular striking combat sports in the world. The aim of this review was to present data concerning performance analysis (time-motion and technical/tactical analysis) and physiological responses (i.e., blood lactate concentration [BLC], heart rate and/or oxygen consumption) during novice and elite male simulated and official amateur boxing competitions in any age category. The present review shows that boxing competition is a high-intensity intermittent striking combat sport. Typically, the activity-to-rest ratio was higher in elite (18:1) than novice (9:1) boxers and significant differences were observed between rounds (1 round=16:1, 2 round=8:1, and 3 round=6:1) in novice boxers...
January 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28081017/lattice-parameters-guide-superconductivity-in-iron-arsenides
#18
Lance M N Konzen, Athena S Sefat
The discovery of superconducting materials has led to their use in technological marvels such as magnetic-field sensors in MRI machines, powerful research magnets, short transmission cables, and high-speed trains. Despite such applications, the uses of superconductors are not widespread because they function much below room-temperature, hence the costly cooling. Since the discovery of Cu- and Fe-based high-temperature superconductors (HTS), much intense effort has tried to explain and understand the superconducting phenomenon...
January 12, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28080323/oral-adenosine-5-triphosphate-atp-administration-increases-postexercise-atp-levels-muscle-excitability-and-athletic-performance-following-a-repeated-sprint-bout
#19
Martin Purpura, John A Rathmacher, Matthew H Sharp, Ryan P Lowery, Kevin A Shields, Jeremy M Partl, Jacob M Wilson, Ralf Jäger
OBJECTIVE: Oral adenosine-5'-triphosphate (ATP) administration has failed to increase plasma ATP levels; however, chronic supplementation with ATP has shown to increase power, strength, lean body mass, and blood flow in trained athletes. The purpose of this study was to investigate the effects of ATP supplementation on postexercise ATP levels and on muscle activation and excitability and power following a repeated sprint bout. METHODS: In a double-blind, placebo-controlled, randomized design, 42 healthy male individuals were given either 400 mg of ATP as disodium salt or placebo for 2 weeks prior to an exercise bout...
January 12, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28079702/radiomic-analysis-reveals-prognostic-information-in-t1-weighted-baseline-magnetic-resonance-imaging-in-patients-with-glioblastoma
#20
Michael Ingrisch, Moritz Jörg Schneider, Dominik Nörenberg, Giovanna Negrao de Figueiredo, Klaus Maier-Hein, Bogdana Suchorska, Ulrich Schüller, Nathalie Albert, Hartmut Brückmann, Maximilian Reiser, Jörg-Christian Tonn, Birgit Ertl-Wagner
OBJECTIVES: The aim of this study was to investigate whether radiomic analysis with random survival forests (RSFs) can predict overall survival from T1-weighted contrast-enhanced baseline magnetic resonance imaging (MRI) scans in a cohort of glioblastoma multiforme (GBM) patients with uniform treatment. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and informed consent was waived. The MRI scans from 66 patients with newly diagnosed GBM from a previous prospective study were analyzed...
January 9, 2017: Investigative Radiology
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