keyword
https://read.qxmd.com/read/38524088/successful-management-of-heterotopic-cervical-pregnancy-after-in-vitro-fertilization-presenting-with-hyperemesis-gravidarum-a-case-report
#21
Chalent Alexakis, Konstantinos Zacharis, Asimina Paraskevi Barmparousi, Stavros Kravvaritis, Theodoros Charitos
Heterotopic pregnancy, defined by the simultaneous existence of intrauterine and ectopic pregnancy, is a rare pathological condition. In women undergoing assisted reproduction techniques, the frequency is higher. The possibility of the simultaneous existence of an ectopic pregnancy, when the certainty of an endometrial pregnancy has been assured, should always be considered with special care. The case of a patient with heterotopic pregnancy with assisted conception and the only symptom being nausea and vomiting is presented...
February 2024: Curēus
https://read.qxmd.com/read/38523990/a-lung-cancer-patient-presenting-with-gynecomastia-an-uncommon-paraneoplastic-syndrome
#22
Ganesh Sanjan, Saikat Banerjee, Ruchi Dua, Prakhar Sharma
Lung cancer is the most common neoplastic disorder associated with paraneoplastic syndromes. The most common paraneoplastic syndromes are the syndrome of inappropriate release of antidiuretic hormone (SIADH), hypercalcemia of malignancy, ectopic Cushing's syndrome, and various other neurological syndromes. A few case reports have reported gynecomastia as a paraneoplastic syndrome. Recognition of this uncommon presentation can aid in the early detection of associated malignancies, thus potentially improving outcomes...
February 2024: Curēus
https://read.qxmd.com/read/38523852/an-unusual-case-of-hypercalcemia-due-to-graft-versus-host-disease
#23
Paras Fatima, Vincent Czerwinski, Sujata Panthi, Chitra Choudhary
BACKGROUND/OBJECTIVE: Hypercalcemia is a common disorder with a wide differential and is most commonly related to malignancy and hyperparathyroidism. Hypercalcemia is a rarely reported consequence of graft-versus-host disease (GVHD) and may be related to a granulomatous manifestation of the common stem cell transplantation procedure. CASE REPORT: A 67-year-old woman with a history of allogenic stem cell transplantation due to myelodysplastic syndrome presented to the bone marrow transplant clinic with dysphagia, muscle aches, and rash...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38523235/rab18-maintains-homeostasis-of-subcutaneous-adipose-tissue-to-prevent-obesity-induced-metabolic-disorders
#24
JOURNAL ARTICLE
Jiaming Liu, Liangkui Li, Dijin Xu, Yuqi Li, Tao Chen, Yeyang Liu, Yuqian Bao, Yan Wang, Longyan Yang, Peng Li, Li Xu
Metabolically healthy obesity refers to obese individuals who do not develop metabolic disorders. These people store fat in subcutaneous adipose tissue (SAT) rather than in visceral adipose tissue (VAT). However, the molecules participating in this specific scenario remain elusive. Rab18, a lipid droplet (LD)-associated protein, mediates the contact between the endoplasmic reticulum (ER) and LDs to facilitate LD growth and maturation. In the present study, we show that the protein level of Rab18 is specifically upregulated in the SAT of obese people and mice...
March 22, 2024: Science China. Life Sciences
https://read.qxmd.com/read/38522306/interstitial-ectopic-pregnancy-a-rare-case-report
#25
Majd Sabbagh, Nehad Othman, Salah Chaikha, Rehab Sukkar, Amal alToto, Lina alQudsi
INTRODUCTION: Interstitial pregnancies are a rare form of ectopic pregnancy with life threatening consequences. Thus, the aim of this report is to shed light on the importance of early diagnosis for optimal outcomes. CASE PRESENTATION: Herein, we present a case of an interstitial ectopic pregnancy in a 31-year-old Syrian female who presented only with mild non-specific abdominal pain. The ultrasound showed a gestational sac in the right horn of the uterus non-communicating with the endometrial cavity suggesting an interstitial ectopic pregnancy...
March 18, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38521502/upregulation-of-cyr61-by-tgf-%C3%AE-and-yap-signaling-exerts-a-counter-suppression-of-hepatocellular-carcinoma
#26
JOURNAL ARTICLE
Cheng Zhang, Wenjing Wei, Shuo Tu, Bo Liang, Chun Li, Yining Li, Weicheng Luo, Yiqing Wu, Xiaohui Dai, Yi Wang, Lijuan Zheng, Liang Hao, Chunbo Zhang, Zhijun Luo, Ye-Guang Chen, Xiaohua Yan
TGF-β and Hippo signaling are two critical pathways engaged in cancer progression by regulating both oncogenes and tumor suppressors, yet how the two pathways coordinately exert their functions in the development of hepatocellular carcinoma (HCC) remains elusive. In this study, we firstly conducted an integrated analysis of public liver cancer databases and our experimental TGF-β target genes, identifying CYR61 as a pivotal candidate gene relating to HCC development. The expression of CYR61 is downregulated in clinical HCC tissues and cell lines than that in the normal counterparts...
March 21, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38521338/preparation-of-black-phosphorus-sodium-alginate-microspheres-with-bone-matrix-vesicle-structure-via-electrospraying-for-bone-regeneration
#27
JOURNAL ARTICLE
Xuanyu Liu, Xuhong He, Mengjin Chen, Yuhui Wang, Chaiqiong Guo, Hao Zhang, Xin Wang, Yanchao Hao, Yan Wei, Ziwei Liang, Liqin Zhao, Danhong Yan, Di Huang
Bone matrix vesicles are commonly acknowledged as the primary site of biomineralization in human skeletal tissue. Black phosphorus has exhibited favorable properties across various chemical and physical domains. In this investigation, a novel composite microsphere was synthesized through the amalgamation of sodium alginate (ALG) with black phosphorus nanosheets (BP) utilizing the electrospray (ES) technique. These microspheres were tailored to mimic the regulatory function of matrix vesicles (MV) upon exposure to a biomimetic mineralization fluid (SBF) during the biomineralization process...
March 21, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38520868/bioactive-compounds-from-nature-antioxidants-targeting-cellular-transformation-in-response-to-epigenetic-perturbations-induced-by-oxidative-stress
#28
REVIEW
Abdelhakim Bouyahya, Saad Bakrim, Sara Aboulaghras, Kawtar El Kadri, Tarik Aanniz, Asaad Khalid, Ashraf N Abdalla, Ahmed A Abdallah, Chrismawan Ardianto, Long Chiau Ming, Nasreddine El Omari
Oxidative stress results from a persistent imbalance in oxidation levels that promotes oxidants, playing a crucial role in the early and sustained phases of DNA damage and genomic and epigenetic instability, both of which are intricately linked to the development of tumors. The molecular pathways contributing to carcinogenesis in this context, particularly those related to double-strand and single-strand breaks in DNA, serve as indicators of DNA damage due to oxidation in cancer cases, as well as factors contributing to epigenetic instability through ectopic expressions...
March 22, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38520803/endometrial-preparation-protocols-did-not-impact-pregnancy-outcomes-of-patients-with-cured-chronic-endometritis
#29
JOURNAL ARTICLE
Hongzhan Zhang, Han Qiu, Zhiqiang Liu, Shuyi Yu, Cong Chen, Yong Zeng, Yuye Li
RESEARCH QUESTION: Do endometrial preparation protocols have an effect on pregnancy outcomes in patients with cured chronic endometritis? DESIGN: A retrospective study was conducted on 3721 infertile patients from December 2018 to August 2020. Endometrial tissues obtained during the proliferative phase were immunostained for CD138. The presence of CD138-positive cells within the stromal cells indicated chronic endometritis. All patients diagnosed with chronic endometritis received oral antibiotics...
November 27, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38520268/a-rare-ectopic-parathyroid-adenoma-in-the-prevertebral-space
#30
JOURNAL ARTICLE
Alex Tran, Manual Molina-Vega
Ectopic parathyroid adenomas are an uncommon etiology of primary hyperparathyroidism. We present a case of a patient admitted to the hospital with severe hypercalcemia and elevated parathyroid hormone levels, in whom imaging revealed two distinct parathyroid masses in the prevertebral space, representing a rare and atypical location for parathyroid tissue. This case highlights the importance of considering ectopic parathyroid adenomas as a potential cause of hyperparathyroidism and discusses the diagnostic challenges and management strategies associated with such cases...
March 23, 2024: American Surgeon
https://read.qxmd.com/read/38518460/gallstone-ileus-an-unusual-complication-of-cholelithiasis-in-a-42-year-old-female-with-no-comorbidities
#31
Khalil Abuzaina, Sulaiman Fakhouri, Zahra I H Makhamre, Wala' K A Alzatari, Merna A B Hazaza, Leen N Y Jawabreh
INTRODUCTION AND IMPORTANCE: Gallstone ileus is a rare condition, accounting for 0.5 % of mechanical small bowel obstructions. It is a misnomer for mechanical intestinal obstruction caused by one or more gallstones impacted within the gastrointestinal tract lumen, which occurs mostly in the elderly and female population. Treated usually by operative enterolithotomy. Preoperative diagnosis is challenging, but CT, which is investigation of choice, and magnetic resonance imaging (MRI) have made it easier to diagnose...
March 19, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38517960/childhood-cancer-mutagenesis-caused-by-transposase-derived-pgbd5
#32
JOURNAL ARTICLE
Makiko Yamada, Ross R Keller, Rodrigo Lopez Gutierrez, Daniel Cameron, Hiromichi Suzuki, Reeti Sanghrajka, Jake Vaynshteyn, Jeffrey Gerwin, Francesco Maura, William Hooper, Minita Shah, Nicolas Robine, Phillip Demarest, N Sumru Bayin, Luz Jubierre Zapater, Casie Reed, Steven Hébert, Ignas Masilionis, Ronan Chaligne, Nicholas D Socci, Michael D Taylor, Claudia L Kleinman, Alexandra L Joyner, G Praveen Raju, Alex Kentsis
Genomic rearrangements are a hallmark of most childhood tumors, including medulloblastoma, one of the most common brain tumors in children, but their causes remain largely unknown. Here, we show that PiggyBac transposable element derived 5 (Pgbd5) promotes tumor development in multiple developmentally accurate mouse models of Sonic Hedgehog (SHH) medulloblastoma. Most Pgbd5-deficient mice do not develop tumors, while maintaining normal cerebellar development. Ectopic activation of SHH signaling is sufficient to enforce cerebellar granule cell progenitor-like cell states, which exhibit Pgbd5-dependent expression of distinct DNA repair and neurodevelopmental factors...
March 22, 2024: Science Advances
https://read.qxmd.com/read/38517882/images-of-an-ectopic-balloon-expandable-valve-deployed-at-the-aortic-arch-level-following-valve-embolization
#33
JOURNAL ARTICLE
Georgios Chalikias, Soultana Foutzitzi, Dimitrios Stakos, Dimitrios Tziakas
An 83-year-old man with severe aortic stenosis underwent implantation of a 29-mm SAPIEN-3 (Edwards Lifesciences) transcatheter aortic valve (TAV) appropriately sized for an aortic annulus area of 543.6 mm2.
March 19, 2024: Journal of Invasive Cardiology
https://read.qxmd.com/read/38517813/laparoscopic-surgery-for-ectopic-pregnancy-a-comparative-study-on-the-clinical-benefits-and-impact-on-tubal-patency-and-reproductive-outcomes
#34
JOURNAL ARTICLE
Juan Yu, Yan Peng, Liqun Yu, Shutian Shi
BACKGROUND: Ectopic pregnancy is a major contributor to maternal morbidity and mortality across the globe. OBJECTIVE: This study aims to investigate the clinical benefits of laparoscopic surgery in treating ectopic pregnancy, and its impact on tubal patency and reproductive outcomes. METHODS: A clinical study was conducted to compare laparoscopic and medical conservative treatment for ectopic pregnancy. A total of 206 patients were treated for ectopic pregnancy at our hospital from January 2018 to June 2020...
February 29, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38517662/intraoperative-radio-guided-localization-of-parathyroid-adenomas-using-3d-freehand-spect-technology
#35
JOURNAL ARTICLE
Stathis Anesidis, Ioanna Akrida, Marina Michalaki, Dimitrios Apostololpoulos, Nikolaos Papathanasiou, Nikolaos Benetatos, Christina Kalogeropoulou, Konstantinos Panagopoulos, Ioannis Maroulis
Parathyroidectomy for primary hyperparathyroidism (PHPT) could have poor outcomes, even with accurate preoperative localization of the adenomas, because their intraoperative localization can be challenging. Freehand single photon emission computed tomography (fhSPECT) is a new technique for radio-guided intraoperative navigation. Its use during parathyroidectomy could be useful and such data are limited. We herein present our experience on the feasibility of fhSPECT for intraoperative detection of abnormal parathyroid glands...
March 22, 2024: Updates in Surgery
https://read.qxmd.com/read/38517430/primary-cilium-in-neural-crest-cells-crucial-for-anterior-segment-development-and-corneal-avascularity
#36
JOURNAL ARTICLE
Seungwoon Seo, Seong Keun Sonn, Hyae Yon Kweon, Jing Jin, Tsutomu Kume, Je Yeong Ko, Jong Hoon Park, Goo Taeg Oh
PURPOSE: Intraflagellar transport 46 (IFT46) is an integral subunit of the IFT-B complex, playing a key role in the assembly and maintenance of primary cilia responsible for transducing signaling pathways. Despite its predominant expression in the basal body of cilia, the precise role of Ift46 in ocular development remains undetermined. This study aimed to elucidate the impact of neural crest (NC)-specific deletion of Ift46 on ocular development. METHODS: NC-specific conditional knockout mice for Ift46 (NC-Ift46F/F) were generated by crossing Ift46F mice with Wnt1-Cre2 mice, enabling the specific deletion of Ift46 in NC-derived cells (NCCs)...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38517027/high-cd62l-expression-predicts-the-generation-of-chimeric-antigen-receptor-t-cells-with-potent-effector-functions
#37
JOURNAL ARTICLE
Hitomi Kasuya, Haosong Zhang, Yusuke Ito, Toshiaki Yoshikawa, Takahiro Nakashima, Yang Li, Tetsuya Matsukawa, Satoshi Inoue, Yuki Kagoya
Efficient generation of chimeric antigen receptor (CAR) T cells is highly influenced by the quality of apheresed T cells. Healthy donor-derived T cells usually proliferate better than patients-derived T cells and are precious resources to generate off-the-shelf CAR-T cells. However, relatively little is known about the determinants that affect the efficient generation of CAR-T cells from healthy donor-derived peripheral blood mononuclear cells (PBMC) compared with those from the patients' own PBMC. We here examined the efficiency of CAR-T cell generation from multiple healthy donor samples and analyzed its association with the phenotypic features of the starting peripheral blood T cells...
March 22, 2024: International Immunology
https://read.qxmd.com/read/38516730/a-root-knot-nematode-effector-targets-the-arabidopsis-cysteine-protease-rd21a-for-degradation-to-suppress-plant-defense-and-promote-parasitism
#38
JOURNAL ARTICLE
Jiarong Yu, Qing Yuan, Chen Chen, Tianyu Xu, Yuwen Jiang, Wenjun Hu, Aolin Liao, Jiayi Zhang, Xiuhu Le, Hongmei Li, Xuan Wang
Meloidogyne incognita is one of the most widely distributed plant-parasitic nematodes and causes severe economic losses annually. The parasite produces effector proteins that play essential roles in successful parasitism. Here, we identified one such effector named MiCE108, which is exclusively expressed within the nematode subventral esophageal gland cells and is upregulated in the early parasitic stage of M. incognita. A yeast signal sequence trap assay showed that MiCE108 contains a functional signal peptide for secretion...
March 22, 2024: Plant Journal
https://read.qxmd.com/read/38516415/central-hyperthyroidism-due-to-an-ectopic-tsh-secreting-pituitary-tumor-a-case-report-and-literature-review
#39
Chonggui Zhu, Tong Liu, Haonan Yu, Lina Chang, Xiaona Zhang, Jia Yao, Geng Zhang, Qiusong Chen, Qing He, Ming Liu
Ectopic thyroid-stimulating hormone (TSH)-secreting tumors are extremely rare, with only 15 reported cases in the literature. Herein, we described a 60-year-old female patient with thyrotoxicosis and elevated or unsuppressed levels of TSH. Family history and laboratory and genetic tests did not support a diagnosis of resistance to thyroid hormone (RTH). Given the unsuppressed TSH, TSH-secreting tumor was suspected, and magnetic resonance imaging (MRI) of the pituitary gland was performed. Surprisingly, the MRI scans revealed a nodule in the nasopharynx rather than a pituitary tumor in the sella region...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38515631/management-of-ectopic-pregnancy-after-in-vitro-fertilization-intracytoplasmic-sperm-injection-and-embryo-transfer-a-case-series-and-mini-review
#40
JOURNAL ARTICLE
Yang Zhang, Yan Zhai, Danni Qu
BACKGROUND: Ectopic pregnancy (EP), reflecting a fertilized ovum implanted outside the normal uterine cavity, represents a frequent cause of morbidity and possibly mortality in women of reproductive age. OBJECTIVE: To summarize the diagnosis and treatment of EP after in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET). METHODS: The medical records of patients who were diagnosed with EP after embryo transfer from 2017 to 2019, in a tertiary hospital were reviewed...
February 2024: Asian Biomedicine: Research, Reviews and News
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