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https://www.readbyqxmd.com/read/29148972/rapid-dna-replication-origin-licensing-protects-stem-cell-pluripotency
#1
Jacob Peter Matson, Raluca Dumitru, Philip Coryell, Ryan M Baxley, Weili Chen, Kirk Twaroski, Beau R Webber, Jakub Tolar, Anja-Katrin Bielinsky, Jeremy E Purvis, Jeanette Gowen Cook
Complete and robust human genome duplication requires loading MCM helicase complexes at many DNA replication origins, an essential process termed origin licensing. Licensing is restricted to G1 phase of the cell cycle, but G1 length varies widely among cell types. Using quantitative single cell analyses we found that pluripotent stem cells with naturally short G1 phases load MCM much faster than their isogenic differentiated counterparts with long G1 phases. During the earliest stages of differentiation towards all lineages, MCM loading slows concurrently with G1 lengthening, revealing developmental control of MCM loading...
November 17, 2017: ELife
https://www.readbyqxmd.com/read/29148642/rare-co-existence-of-coronary-anomalies-anomaly-of-origin-and-distribution-together-with-anomaly-of-intrinsic-coronary-artery-anomaly
#2
Abraha Hailu, Diana Chin, Carmine Musto, Rosario Fiorilli, Roberto Violini
We describe a 63 year old Romanian female patient admitted to our institution with complaints of typical angina and a diagnosis of non ST-elevation myocardial infarction. Coronary arteriography unveiled anomalous origin of a left circumflex coronary artery from the right coronary sinus of Valsalva near the right coronary ostium and a hyperdominant left anterior descending coronary artery giving off a posterior descending coronary artery with small distal-posterolateral left ventricular branch. The co-existence of a left circumflex coronary artery originating ectopically from the right sinus of Valsalva together with a posterior descending coronary artery originating from the distal end of the anterior descending artery is important to keep in mind especially by those doing coronary angiography in the cardiac catheterization laboratory...
January 2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/29148196/umbilicus-and-its-extensive-clinical-repertoire
#3
Spencer W Beasley
The umbilicus is involved in a wide range of abnormalities in infants and children. The most severe are evident at birth and include exomphalos (omphalocele) and gastroschisis, both of which can be life-threatening but are easy to diagnose. Exomphalos is often associated with other congenital abnormalities, whereas the associated problems in gastroschisis are largely confined to the gut. Infection of the umbilicus in the neonate presents as omphalitis. The causes of a moist umbilicus following separation of the umbilical stump are multiple, from the relatively minor umbilical granuloma or ectopic bowel mucosa to the more significant patent urachus that leaks urine...
November 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29147816/development-of-pseudoaneurysm-in-cesarean-section-scar-pregnancy-a-case-report-and-literature-review
#4
Shunki Kiyokawa, Tatsuyuki Chiyoda, Kazunori Ueno, Keiko Saotome, Seon-Hye Kim, Sakura Nakada
Cesarean scar pregnancy (CSP) is a rare type of ectopic pregnancy. It is becoming more common, but it can lead to uterine rupture and severe hemorrhage. Here, we report a case of a 37-year-old woman with CSP complicated with pseudoaneurysm. The pseudoaneurysm emerged following focal injection of methotrexate (MTX) and potassium chloride with systemic MTX treatment. Due to a risk of sudden bleeding, uterine artery embolization (UAE) was recommended, but the patient hoped to avoid this if possible. Because the serum human chorionic gonadotropin level and the gestational sac were still persistent, dilation and curettage were performed with interventional radiologists on standby...
November 16, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29147786/risk-factors-for-development-of-ectopic-atrial-tachycardia-in-post-operative-congenital-heart-disease
#5
Bradley C Clark, John T Berger, Charles I Berul, Richard A Jonas, Jonathan R Kaltman, Julianne Lapsa, Dilip S Nath, Elizabeth D Sherwin, Pranava Sinha, David Zurakowski, Jeffrey P Moak
Ectopic atrial tachycardia (EAT) is common in surgically repaired congenital heart disease (CHD) and carries the potential for significant hemodynamic compromise. Our objective was to determine the incidence, and risk factors of EAT after CHD surgery. Prospective study of patients that underwent surgery for CHD from February to October 2016 was performed. Demographic, perioperative and electrophysiologic data were collected. Sustained EAT (> 30 s) was documented by telemetry or electrocardiogram and confirmed by a pediatric electrophysiologist...
November 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29147713/variation-of-the-bone-forming-ability-with-the-physicochemical-properties-of-calcium-phosphate-bone-substitutes
#6
Rongquan Duan, Davide Barbieri, Xiaoman Luo, Jie Weng, Chongyun Bao, Joost D de Bruijn, Huipin Yuan
Because of their bioactive properties and chemical similarity to the inorganic component of bone, calcium phosphate (CaP) materials are widely used for bone regeneration. Six commercially available CaP bone substitutes (Bio-Oss, Actifuse, Bi-Ostetic, MBCP, Vitoss and chronOs) as well as two tricalcium phosphate (TCP) ceramics with either a micron-scale (TCP-B) or submicron-scale (TCP-S) surface structure are characterized and their bone forming potential is evaluated in a canine ectopic implantation model. After 12 weeks of implantation in the paraspinal muscle of four beagles, sporadic bone (0...
November 17, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29147488/the-downregulation-of-atg4b-mediated-by-microrna-34a-34c-5p-suppresses-rapamycin-induced-autophagy
#7
Yaran Wu, Xufang Dai, Zhenhong Ni, Xiaojing Yan, Fengtian He, Jiqin Lian
Objectives: Autophagy-related 4B (ATG4B) plays an important role in the process of autophagy induction. However, the molecular events that govern the expression of ATG4B in this process are not well known. Materials and Methods: Human ATG4B 3'-UTR region (1377 nt) containing miR-34a/miR-34c-5p binding site was amplified by PCR. Luciferase assay was used to assess the activity of reporter genes. Real-time PCR was used to detect the levels of miR-34a and miR-34c-5p...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29147031/metabolic-disease-ectopic-olfactory-receptor-activation-reverses-obesity
#8
Sarah Crunkhorn
No abstract text is available yet for this article.
November 17, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/29147008/the-transcription-factor-batf3-inhibits-the-differentiation-of-regulatory-t-cells-in-the-periphery
#9
Wonyong Lee, Hyeong Su Kim, Soo Seok Hwang, Gap Ryol Lee
Naive CD4 T cells activated by antigen-presenting cells (APCs) undergo terminal differentiation in the periphery. Multiple mechanisms determine their fates, that is, whether they differentiate into conventional T (Tconv) cells or regulatory T (Treg) cells. The key event during Treg generation is expression of the transcription factor Foxp3, which is the lineage-determining regulator for Treg differentiation and function. Here we show that the transcription factor Batf3 acts as a fate-decision factor with respect to Tconv versus Tregs by restraining Treg differentiation...
November 17, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29146875/risk-of-stroke-in-patients-with-short-run-atrial-tachyarrhythmia
#10
Shinya Yamada, Chin-Yu Lin, Shih-Lin Chang, Tze-Fan Chao, Yenn-Jiang Lin, Li-Wei Lo, Fa-Po Chung, Yu-Feng Hu, Ta-Chuan Tuan, Jo-Nan Liao, Abigail Louise D Te, Yao-Ting Chang, Ting-Yung Chang, Cheng-I Wu, Satoshi Higa, Shih-Ann Chen
BACKGROUND AND PURPOSE: The risk of stroke in patients with short-run atrial tachyarrhythmia (AT) remains unclear. This study aimed to investigate the relationship between short-run AT and the stroke and the use of the CHA2DS2-VASc score for the risk stratification. METHODS: From the registry of 24-hour Holter monitoring, 5342 subjects without known atrial fibrillation or stroke were enrolled. Short-run AT was defined as episodes of supraventricular ectopic beats <5 seconds...
November 16, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29146275/beat-to-beat-variations-in-activation-recovery-interval-derived-from-the-right-ventricular-electrogram-can-monitor-arrhythmic-risk-under-anesthetic-and-awake-conditions-in-the-canine-chronic-atrioventricular-block-model
#11
Sofieke C Wijers, David J Sprenkeler, Alexandre Bossu, Albert Dunnink, Jet D M Beekman, Rosanne Varkevisser, Alfonso Aranda Hernández, Mathias Meine, Marc A Vos
BACKGROUND: In the chronic atrioventricular block (CAVB) dog model, beat-to-beat variation of repolarization in the left ventricle (LV) quantified as short-term variability of the left monophasic action potential duration (STVLVMAPD) increases abruptly upon challenge with a pro arrhythmic drug. This increase occurs before the first ectopic beat (EB), specifically in subjects that demonstrate subsequent repetitive Torsade de Pointes arrhythmias (TdP). OBJECTIVE: Demonstrate that STV is feasible to monitor arrhythmic risk through the use of the intracardiac electrogram (EGM) derived from the right ventricle (RV) lead from pacemakers or implantable cardioverter defibrillators (ICD)...
November 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29146062/three-cases-of-adrenocortical-tumors-mistaken-for-hepatocellular-carcinomas-diagnostic-pitfalls-and-differential-diagnosis
#12
Won Young Park, Hyung Il Seo, Kyung Un Choi, Ahrong Kim, Young Keum Kim, So Jeong Lee, Chang Hun Lee, Gi Yeong Huh, Do Youn Park
Adrenocortical adenomas and carcinomas in other parenchyma are extremely rare, with few cases reported and because of the rarity of these tumors, they occasionally cause problems during diagnosis. Adrenal cortical neoplasms in liver parenchyma can be present in 3 forms, including direct invasion or adhesion to liver parenchyma, tumors arising in adrenohepatic fusion tissue or in ectopic adrenal gland tissue. We report 3 cases of adrenal cortical tumors that were misdiagnosed as hepatocellular carcinoma in the preoperative state...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29146023/longitudinal-associations-of-pericardial-and-intrathoracic-fat-with-progression-of-coronary-artery-calcium-from-the-framingham-heart-study
#13
Jane J Lee, Alison Pedley, Udo Hoffmann, Joseph M Massaro, Christopher J O'Donnell, Emelia J Benjamin, Michelle T Long
Cross-sectional studies have shown that pericardial fat is associated with atherosclerotic burden above and beyond generalized and central adiposity. Whether pericardial fat is longitudinally associated with coronary artery calcium (CAC) has not been firmly established. We examined the associations between cardiac ectopic fat including pericardial and intrathoracic fat with CAC progression and incidence in a community-based study setting. Study participants were from the Framingham Heart Study Offspring and Third Generation Cohorts who underwent multidetector computed tomography at 2 consecutive examinations (2002 to 2005 and 2008 to 2011) for the assessment of CAC...
October 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29145393/estimating-the-probabilities-of-rare-arrhythmic-events-in-multiscale-computational-models-of-cardiac-cells-and-tissue
#14
Mark A Walker, Viatcheslav Gurev, John J Rice, Joseph L Greenstein, Raimond L Winslow
Ectopic heartbeats can trigger reentrant arrhythmias, leading to ventricular fibrillation and sudden cardiac death. Such events have been attributed to perturbed Ca2+ handling in cardiac myocytes leading to spontaneous Ca2+ release and delayed afterdepolarizations (DADs). However, the ways in which perturbation of specific molecular mechanisms alters the probability of ectopic beats is not understood. We present a multiscale model of cardiac tissue incorporating a biophysically detailed three-dimensional model of the ventricular myocyte...
November 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29145324/a-rare-case-of-merkel-cell-carcinoma-presenting-as-a-giant-intra-thoracic-mass-a-case-report-and-review-of-the-literature
#15
Feng-Wei Kong, Miao Zhang, Heng Wang, Cun-Tao Lu, Wen-Bin Wu, Yuan-Yuan Liu
RATIONALE: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine-derived cutaneous cancer. Ectopic or single metastatic MCC located in thorax is extremely rare; meanwhile, its definite management has not been elucidated yet. PATIENT CONCERNS: A 64-year-old female patient with a giant mass located in her left thorax was presented for stuffy pain of left chest for 6 months and fever for half a month. She underwent radical resection of vulvar MCC 10 years ago...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145128/microgravity-simulation-activates-cdc42-via-rap1gds1-to-promote-vascular-branch-morphogenesis-during-vasculogenesis
#16
Shouli Wang, Zhao Yin, Bei Zhao, Yanmei Qi, Jie Liu, Saum A Rahimi, Leonard Y Lee, Shaohua Li
Gravity plays an important role in normal tissue maintenance. The ability of stem cells to repair tissue loss in space through regeneration and differentiation remains largely unknown. To investigate the impact of microgravity on blood vessel formation from pluripotent stem cells, we employed the embryoid body (EB) model for vasculogenesis and simulated microgravity by clinorotation. We first differentiated mouse embryonic stem cells into cystic EBs containing two germ layers and then analyzed vessel formation under clinorotation...
November 7, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29144629/single-perineal-incision-placement-of-artificial-urinary-sphincter-with-cadaveric-correlation-of-sub-dartos-pump-placement
#17
Cooper R Benson, Hajar I Ayoub, O Lenaine Westney
PURPOSE: We present a novel AUS implantation technique using a single perineal incision for single device placement or in combination with an inflatable penile prosthesis (IPP). Urinary and sexual dysfunction following the management of prostate cancer has a significant impact on the quality of life of our patients. While there are marginal changes in the prosthetic devices, we strive to reduce post-operative morbidity while maximizing efficacy. MATERIALS AND METHODS: We retrospectively reviewed the outcomes of 6 patients who underwent single perineal incision placement of a virgin AUS in 2014, 3 with simultaneous IPP placement...
November 19, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29143993/how-to-measure-size-of-tubal-ectopic-pregnancy-on-ultrasound-scan
#18
K Rajah, V Goodhart, K P Zamora, T Amin, E Jauniaux, D Jurkovic
OBJECTIVE: To identify the preoperative ultrasound measurements for assessing the size of tubal ectopic pregnancy which correlate best with the findings at surgery. METHODS: We conducted a prospective study of all women with a conclusive transvaginal ultrasound diagnosis of tubal ectopic pregnancy over a 10-month period. In each case, we measured the total size of the ectopic pregnancy by placing the calipers on the outer edges of the visible trophoblastic tissue...
November 16, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29143545/taz-responds-to-fluid-shear-stress-to-regulate-the-cell-cycle
#19
Hyun Jung Lee, Adesuwa Ewere, Miguel F Diaz, Pamela L Wenzel
Physical forces associated with tumor growth and drainage alter cancer cell invasiveness and metastatic potential. We previously showed that fluid frictional force, or shear stress, typical of lymphatic flow induces YAP1/TAZ activation in prostate cancer cells to promote motility dependent upon YAP1 but not TAZ. Here, we show that shear stress elevates TAZ protein levels and promotes TAZ nuclear localization. Increased TAZ activity drives increased DNA synthesis and induces AMOTL2, ANKRD1, and CTGF gene transcription independently of YAP1...
November 16, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29143349/growth-rate-rather-than-growth-duration-drives-growth-heterosis-in-maize-b104-hybrids
#20
Kim Feys, Kirin Demuynck, Jolien De Block, Anchal Bisht, Alex De Vliegher, Dirk Inzé, Hilde Nelissen
Research in maize is often performed using inbred lines which can be readily transformed, such as B104. However, B104 flowers late so that the kernels not always mature before the end of the growing season, hampering routine seed yield evaluations of biotech traits introduced in B104 at many geographical locations. Therefore, we generated five hybrids by crossing B104 with the early-flowering inbred lines CML91, F7, H99, Mo17 and W153R and showed in three consecutive years that the hybrid lines proved to be suitable to evaluate seed yield under field conditions in a temperate climate...
November 16, 2017: Plant, Cell & Environment
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