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https://www.readbyqxmd.com/read/28109658/intra-articular-ectopic-ossification-associated-with-denosumab-administration-for-giant-cell-tumor-of-bone-with-intra-articular-pathological-fracture
#1
Eiji Osaka, Yuki Okamura, Yukihiro Yoshida, Masahiko Sugitani, Yasuaki Tokuhashi
No abstract text is available yet for this article.
January 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28109288/long-intergenic-non-coding-rna-00152-promotes-lung-adenocarcinoma-proliferation-via-interacting-with-ezh2-and-repressing-il24-expression
#2
Qin-Nan Chen, Xin Chen, Zhen-Yao Chen, Feng-Qi Nie, Chen-Chen Wei, Hong-Wei Ma, Li Wan, Shuai Yan, Sheng-Nan Ren, Zhao-Xia Wang
BACKGROUND: Numerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such as cell proliferation, apoptosis, migration, and invasion. LINC00152 is located on chromosome 2p11.2, and has a transcript length of 828 nucleotides. The biological role of LINC00152 in LAD(lung adenocarcinoma) remains unknown. METHODS: Quantitative reverse transcription PCR(qRT-PCR) was used to detect LINC00152 expression in 60 human LAD tissues and paired normal tissues...
January 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28109114/-renal-artery-embolization-with-exploratory-laparotomy-for-management-of-massive-colonic-hemorrhage-after-renal-biopsy-a-case-report
#3
Lian-Zi Ma, Zheng-Rong Liu
We report a case of massive colonic hemorrhage after renal biopsy managed by renal artery embolization combined with exploratory laparotomy. Clinicians must be alert for such rare anatomical abnormalities as ectopic colon behind the kidney and the risk of colonic hemorrhage following renal biopsy. In this case, artery embolization combined with exploratory laparotomy successfully and quickly stopped the bleeding and avoided possible organ resection.
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28107780/myb12-and-myb22-play-essential-roles-in-proanthocyanidin-and-flavonol-synthesis-in-red-fleshed-apple-malus-sieversii-f-niedzwetzkyana
#4
Nan Wang, Haifeng Xu, Shenghui Jiang, Zongying Zhang, Ninglin Lu, Huarong Qiu, Changzhi Qu, Yicheng Wang, Shujing Wu, Xuesen Chen
Flavonoids are major polyphenol compounds in plant secondary metabolism. Compared with cultivated apples, wild red-fleshed apples (Malus sieversii f. niedzwetzkyana) are excellent resources because of their high flavonoid content. In this work, R6R6, R6R1 and R1R1 genotypes were identified in an F1 segregating population of M. sieversii f. niedzwetzkyana. Significant differences in flavonoid compositions and contents were detected among the three genotypes by UPLC-ESI-TOF/MS analysis. Furthermore, two putative flavonoid-related genes encoding R2R3-MYB transcription factors, designated MYB12 and MYB22, were cloned and characterized...
January 20, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28107519/cudraflavone-c-induces-tumor-specific-apoptosis-in-colorectal-cancer-cells-through-inhibition-of-the-phosphoinositide-3-kinase-pi3k-akt-pathway
#5
Hsien-Chuen Soo, Felicia Fei-Lei Chung, Kuan-Hon Lim, Veronica Alicia Yap, Tracey D Bradshaw, Ling-Wei Hii, Si-Hoey Tan, Sze-Jia See, Yuen-Fen Tan, Chee-Onn Leong, Chun-Wai Mai
Cudraflavone C (Cud C) is a naturally-occurring flavonol with reported anti-proliferative activities. However, the mechanisms by which Cud C induced cytotoxicity have yet to be fully elucidated. Here, we investigated the effects of Cud C on cell proliferation, caspase activation andapoptosis induction in colorectal cancer cells (CRC). We show that Cud C inhibits cell proliferation in KM12, Caco-2, HT29, HCC2998, HCT116 and SW48 CRC but not in the non-transformed colorectal epithelial cells, CCD CoN 841. Cud C induces tumor-selective apoptosis via mitochondrial depolarization and activation of the intrinsic caspase pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28107238/roles-of-the-endoplasmic-reticulum-stress-transducer-oasis-in-ossification-of-the-posterior-longitudinal-ligament
#6
Yu Chen, Haisong Yang, Jinhao Miao, Xiaowei Liu, Xinwei Wang, Deyu Chen
STUDY DESIGN: In vitro molecular research on the posterior longitudinal ligament fibroblasts. OBJECTIVE: To investigate different expression of old astrocyte specifically induced substance (OASIS) between spinal ligament fibroblasts from the patients with ossification of the posterior longitudinal ligament (OPLL) and from non-OPLL patients and demonstrate knockdown of OASIS protein expression by RNA interference inhibiting expression of type I collagen (COL I) in OPLL cells...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28106911/positron-emission-tomography-computed-tomography-imaging-of-adrenocorticotropic-hormone-producing-small-cell-neuroendocrine-carcinoma-of-the-cervix
#7
Vien X Nguyen, Ba D Nguyen, Dora M Lam-Himlin
Ectopic ACTH-dependent Cushing syndrome-inducing small-cell neuroendocrine carcinoma of the cervix, undiagnosed by computed tomography and whole-body octreotide scintigraphy, was identified using F-18 FDG PET/CT imaging. This article is protected by copyright. All rights reserved.
January 20, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28106818/potential-benefits-and-harms-of-intermittent-energy-restriction-and-intermittent-fasting-amongst-obese-overweight-and-normal-weight-subjects-a-narrative-review-of-human-and-animal-evidence
#8
REVIEW
Michelle Harvie, Anthony Howell
Intermittent energy restriction (IER) has become popular as a means of weight control amongst people who are overweight and obese, and is also undertaken by normal weight people hoping spells of marked energy restriction will optimise their health. This review summarises randomised comparisons of intermittent and isoenergetic continuous energy restriction for weight loss to manage overweight and obesity. It also summarises the potential beneficial or adverse effects of IER on body composition, adipose stores and metabolic effects from human studies, including studies amongst normal weight subjects and relevant animal experimentation...
January 19, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28106301/uxt-is-a-lox-pp-interacting-protein-that-modulates-estrogen-receptor-alpha-activity-in-breast-cancer-cells
#9
Nuria Sánchez-Morgan, Kathrin H Kirsch, Philip C Trackman, Gail E Sonenshein
The lysyl oxidase proenzyme propeptide region (LOX-PP) is a tumor suppressor protein whose mechanism of action is not completely understood. Here, the Ubiquitously eXpressed Transcript (UXT) was identified in a yeast two-hybrid assay with LOX-PP as bait and confirmed as a novel LOX-PP associating protein. UXT, a prefoldin-like protein, is ubiquitous in human and mouse. Since UXT modulates androgen receptor transcriptional activity in prostate cancer, we studied its role in breast cancer. Breast tumors and derived cell lines overexpressed UXT...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28106124/effect-of-myocyte-fibroblast-coupling-on-the-onset-of-pathological-dynamics-in-a-model-of-ventricular-tissue
#10
S Sridhar, Nele Vandersickel, Alexander V Panfilov
Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence it is very important to understand the factors underlying such arrhythmias. While early afterdepolarizations (EAD) of cardiac cells is known to be one such arrhythmogenic factor, the mechanisms underlying the emergence of tissue level arrhythmias from cellular level EADs is not fully understood. Another known arrhythmogenic condition is fibrosis of cardiac tissue that occurs both due to aging and in many types of heart diseases...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105850/next-generation-tau-models-in-alzheimer-s%C3%A2-disease-research-virus-based-gene-delivery-systems
#11
V Cubinková, B Valachová, V Brezovaková, R Szabó, I Zimová, Z Kostecká, S Jadhav
Alzheimer's disease (AD) the most common form of dementia is characterized by cognitive decline and progressive loss of neurons in the central nervous system. Despite huge scientific progress, there are only few animal models that recapitulate at least majority of the AD pathology and related symptomatology. Therefore, alternative methods to develop animal models for neurodegenerative diseases are constantly explored. Recently, recombinant adeno-associated viruses (AAVs) are widely used viral vectors in development of novel models for neurodegenerative diseases...
January 19, 2017: Acta Virologica
https://www.readbyqxmd.com/read/28105244/her2-overexpression-reverses-the-relative-resistance-of-egfr-mutant-h1975-cell-line-to-gefitinib
#12
Jing Xu, Li Shen, Bi-Cheng Zhang, Wen-Hong Xu, Shu-Qin Ruan, Chi Pan, Qi-Chun Wei
Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) that has been demonstrated to be clinically useful for the treatment of patients with non-small cell lung cancer (NSCLC). However, ~50% of patients do not respond to EGFR TKI treatment through the emergence of mutations, such as T790M. Therefore, it is important to determine which patients are eligible for treatment with gefitinib. As a preferred dimerization partner for EGFR, the role of EGFR 2 (HER2) in mediating sensitivity to gefitinib is poorly understood...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105222/curcumin-suppresses-the-proliferation-of-gastric-cancer-cells-by-downregulating-h19
#13
Gao Liu, Tian Xiang, Quan-Feng Wu, Wei-Xing Wang
Curcumin, a major phytochemical in turmeric, inhibits the proliferation of many types of solid cancer cells by enhancing p53 expression. However, the long non-coding RNA H19 directly inhibits p53 activation and thus promotes gastric cancer progression. The aim of this study was to assess the role of H19 in curcumin-induced proliferative inhibition of gastric cancer. The gastric cancer cell line SGC-7901 was treated with curcumin at different concentrations and time points. The effect of curcumin on proliferation was assessed using cell counting kit-8 assays and flow cytometry with Ki67 staining...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105209/upregulated-microrna-143-inhibits-cell-proliferation-in-human-nasopharyngeal-carcinoma
#14
Benfu He, Zhe Xu, Jinzhang Chen, Dayong Zheng, Aimin Li, Luo-Sheng Zhang
The aim of the present study was to investigate the possible functions and mechanism of microRNA (miR)-143 in cell proliferation of human nasopharyngeal carcinoma (NPC). The expression of miR-143 in NPC cells and tissues was investigated using reverse transcription-quantitative polymerase chain reaction. Cell viability assay, colony formation assay and flow cytometry were used to examine the cell proliferative ability and tumorigenicity. The expression levels of p21(Cip1), p27(Kip1), cyclin D1, phosphorylated (p)-retinoblastoma protein (Rb), Rb and cyclin-dependent kinase (CDK) 6 were determined by western blotting...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105198/a-circulating-tumor-cell-cluster-based-model-for-tumor-metastasis-hypothesis
#15
Yupeng Hong, Ziduo Li, Qi Zhang
Metastasis is the major cause of mortality in patients with malignancies; however, the mechanisms of tumor cell dissemination and metastasis formation are obscure. Circulating tumor cells (CTCs) are believed to be a critical step for distant metastasis and are associated with a poor patient prognosis. The precise processes of metastasis formation from CTCs are vague. In the present study, we hypothesize that two CTC cluster-based mechanisms of tumor cell inoculation in ectopic organs may be viable: i) Formation of a micro-cancer embolus due to interception of CTC clusters by small vessels; and ii) formation of micrometastasis in an extravasation-dependent or -independent manner...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105154/upregulation-of-microrna-181b-inhibits-ccl18-induced-breast-cancer-cell-metastasis-and-invasion-via-the-nf-%C3%AE%C2%BAb-signaling-pathway
#16
Lei Wang, Yu-Xia Wang, Li-Ping Chen, Ming-Li Ji
The purpose of the present study was to investigate the effects of upregulating microRNA (miR)-181b expression in tumor-associated macrophages regarding breast cancer cell metastasis and to identify the target gene. Ectopic miR-181b was transfected into MDA-MB-231 and MCF-7 breast cancer cell lines with or without chemokine ligand 18 (CCL18) stimulation. Cell proliferation, migration/invasion and apoptosis rate were investigated. The binding effects of miR-181b to the 3'-untranslated region (UTR) of the nuclear factor (NF)-κB gene were detected with the dual luciferase reporter system...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105107/long-time-vs-short-time-insemination-of-sibling-eggs
#17
Jing Liu, Xiao Zhang, Yue Yang, Junliang Zhao, Dayong Hao, Jianrui Zhang, Yanli Liu, Wenbin Wu, Xingling Wang
This study aimed to evaluate the impact of a short insemination procedure on embryo development, assess the reliability of a fertilization check prior to the appearance of pronuclei and elucidate the role of rescue intracytoplasmic sperm injection (R-ICSI). Patients who had ≥9 eggs, were aged <38 years and had normal semen samples were included. The sibling eggs of each patient were divided into two groups; one half for conventional in vitro fertilization (IVF; insemination time, 20 h) and the other half for short insemination (insemination time, 5 h)...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28105096/nocardiosis-in-ectopic-acth-syndrome-a-case-report-and-review-of-11-cases-from-the-literature
#18
Lichen Xu, Qiaomai Xu, Meifang Yang, Hainv Gao, Mingzhi Xu, Weihang Ma
Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) associated with nocardiosis is rare, and little information is available regarding its clinical characteristics. In this study, the case of a 35-year-old male patient who showed significant cushingoid features and had a cough with yellow phlegm for 1 month is described. Pulmonary computed tomography (CT) scanning and (18)F-fluorodeoxyglucose positron emission tomography combined with CT identified two different lesions in the mediastinum and pulmonary region, respectively...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28104809/gpnmb-promotes-proliferation-of-developing-eosinophils
#19
Sae Mi Hwang, Jin Hyun Kang, Bo Kyum Kim, Tae Gi Uhm, Hye Jung Kim, Hyune-Hwan Lee, Bert Binas, Il Yup Chung
Glycoprotein non-metastatic melanoma protein B (GPNMB) is a type I transmembrane protein that is expressed in a wide variety of cell types, including hematopoietic lineages. We previously demonstrated that GPNMB is one of the most highly expressed genes at an early and intermediate stage of eosinophil development. We herein examined GPNMB expression and its possible functional effect using cord blood (CB) CD34(+) hematopoietic stem cells differentiating toward eosinophils during a 24-day culture period. Western blot and confocal microscopy analyses showed that GPNMB reached its highest levels at day 12 with most GPNMB-positive cells also expressing major basic protein 1 (MBP1), an eosinophil granule protein...
January 18, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28104634/structural-connectivity-analysis-in-children-with-segmental-callosal-agenesis
#20
M Severino, D Tortora, B Toselli, S Uccella, M Traverso, G Morana, V Capra, E Veneselli, M M Fato, A Rossi
BACKGROUND AND PURPOSE: Segmental callosal agenesis is characterized by the absence of the intermediate callosal portion. We aimed to evaluate the structural connectivity of segmental callosal agenesis by using constrained spherical deconvolution tractography and connectome analysis. MATERIALS AND METHODS: We reviewed the clinical-radiologic features of 8 patients (5 males; mean age, 3.9 years). Spherical deconvolution and probabilistic tractography were performed on diffusion data...
January 19, 2017: AJNR. American Journal of Neuroradiology
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