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https://www.readbyqxmd.com/read/28811539/intraoperative-parathyroid-localization-with-near-infrared-fluorescence-imaging-using-indocyanine-green-during-total-parathyroidectomy-for-secondary-hyperparathyroidism
#1
Le Cui, Yang Gao, Heping Yu, Min Li, Birong Wang, Tao Zhou, Qinggang Hu
The detection of all glands during total parathyroidectomy (TPTX) in secondary hyperparathyroidism (SHPT) patients is often difficult due to their variability in number and location. The objective of this study was to evaluate the feasibility of near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG) for intraoperative parathyroid gland (PTG) localization in SHPT patients. Twenty-nine patients with SHPT were divided into two groups with or without intraoperative NIRF imaging. ICG was administered in patients undergoing intraoperative imaging, and the fluorescence of PTGs was assessed...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810733/doxorubicin-and-indocyanine-green-loaded-hybrid-bicelles-for-fluorescence-imaging-guided-synergetic-chemo-photothermal-therapy
#2
Li Lin, Xiaolong Liang, Yunxue Xu, Yongbo Yang, Xiaoda Li, Zhifei Dai
Hybrid bicelles have been demonstrated to have great potential for hydrophobic drug delivery. Herein, we report a near-infrared light-driven, temperature-sensitive hybrid bicelles co-encapsulating hydrophobic doxorubicin (DOX) and indocyanine green (ICG) (DOX/ICG@HBs). Encapsulation of ICG into the lipid bilayer membrane of DOX/ICG@HBs results in higher photostability than free ICG. DOX/ICG@HBs exhibited temperature-regulated drug release behavior and significant photothermal cytotoxicity. After tail vein injection, such discotic nanoparticles of DOX/ICG@HBs were found to accumulate selectively at the tumor site and act as an efficient probe to enhance fluorescence imaging greatly...
August 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28810055/impact-of-mir-26b-on-cardiomyocyte-differentiation-in-p19-cells-through-regulating-canonical-non-canonical-wnt-signalling
#3
Duo Wang, Chang Liu, Yumei Wang, Wenjing Wang, Kang Wang, Xiujuan Wu, Zhigang Li, Cuimei Zhao, Li Li, Luying Peng
BACKGROUND AND OBJECTIVES: The control of cardiomyocyte differentiation is tightly linked to microRNAs (miRNAs), which have been emerging as important players in heart development. However, the regulation mechanisms mediated by miRNAs in early heart development remains speculative. Here, we evaluated the impact of miR-26b during the progression of cardiomyocyte differentiation from the P19 cell line. MATERIALS AND METHODS: The overexpression of miR-26b in P19 cells was performed by transduction with lentivirus vector...
August 15, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28807805/laparoscopic-sentinel-node-mapping-in-cervical-and-endometrial-malignancies-a-case-control-study-comparing-two-near-infrared-fluorescence-systems
#4
Alessandro Buda, Giampaolo Di Martino, Elena De Ponti, Paolo Passoni, Federica Sina, Claudio Reato, Francesca Vecchione, Daniela Giuliani
STUDY OBJECTIVE: the goal of this study was to evaluate the intraoperative and perioperative surgical outcomes of two different florescence systems commonly utilized for sentinel lymph node (SLN) mapping in women with early stage cervical cancer or endometrial cancer. DESIGN: Case-control study. DESIGN CLASSIFICATION: Canadian Task-force II-2 SETTING: The study was conducted in the Gynecology Oncology Surgical Unit of the San Gerardo Hospital, Italy...
August 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28801595/spectral-characteristics-of-voltage-sensitive-indocyanine-green-fluorescence-in-the-heart
#5
Regina Mačianskienė, Mantė Almanaitytė, Rimantas Treinys, Antanas Navalinskas, Rimantas Benetis, Jonas Jurevičius
Indocyanine green (ICG) fluorescent dye has been approved by the FDA for use in medical diagnostics. Recently, we demonstrated that ICG dye has voltage-sensitive properties with a dual-component (fast and slow) response in the Langendorff-perfused rabbit heart. Here, we extended our studies by showing the different spectral properties of both components for analysis of the fractional change in ICG fluorescence in response to voltage changes. We used light from four LEDs to obtain excitation; emission was measured using an EMCCD camera with band-pass filters and a spectrometer...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797828/gene-expression-profiling-of-fima-gene-encoding-fimbriae-among-clinical-isolates-of-porphyromonas-gingivalis-in-response-to-photo-activated-disinfection-therapy
#6
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: The endodontic infection therapy majorly aims to eradicate the microbial pathogens. Photo-activated disinfection (PAD), also known as antimicrobial photodynamic therapy, is an alternative antimicrobial modality used to control the microorganisms causing endodontic infections. Notably, microorganisms may be exposed to sub-lethal doses of PAD (sPAD), influencing microbial virulence. The present study assessed the effects of sPAD on expression profiling of the gene associated with the biofilm formation being the most essential virulence factor in Porphyromonas gingivalis strain cells that survive the photodynamic reatment in vivo...
August 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28779958/efficacy-of-indocyanine-green-mediated-sonodynamic-therapy-on-rheumatoid-arthritis-fibroblast-like-synoviocytes
#7
Qin Tang, Shufang Chang, Zhonghua Tian, Jiangchuan Sun, Lan Hao, Zhigang Wang, Shenyin Zhu
Sonodynamic therapy (SDT) has become a new therapeutic method because of its activation of certain sensitizers by ultrasound. Some studies have reported that indocyanine green (ICG) has the characteristics of a sonosensitizer and favorable fluorescence imaging in synovitis of early inflammatory arthritis. In this study, we aimed to investigate the cytotoxic effect of ICG-mediated SDT on MH7A cells in vitro and the potential mechanisms involved. ICG was found to be taken up mainly in cytoplasm, with maximal uptake in 4 h...
August 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28777501/liposome-indocyanine-green-nanoprobes-for-optical-labeling-and-tracking-of-human-mesenchymal-stem-cells-post-transplantation-in-vivo
#8
Mariarosa Mazza, Neus Lozano, Debora Braga Vieira, Maurizio Buggio, Cay Kielty, Kostas Kostarelos
Direct labeling of human mesenchymal stem cells (hMSC) prior to transplantation provides a means to track cells after administration and it is a powerful tool for the assessment of new cell-based therapies. Biocompatible nanoprobes consisting of liposome-indocyanine green hybrid vesicles (liposome-ICG) are used to safely label hMSC. Labeled hMSC recapitulating a 3D cellular environment is transplanted as spheroids subcutaneously and intracranially in athymic nude mice. Cells emit a strong NIR signal used for tracking post-transplantation with the IVIS imaging system up to 2 weeks (subcutaneous) and 1 week (intracranial)...
August 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28766279/spectrum-of-pachychoroid-diseases
#9
REVIEW
Sezen Akkaya
PURPOSE: To perform a systematic review of the literature examining about the pachychoroid diseases spectrum. METHODS: A systematic literature search was performed using the Medline database. A total of four studies directly relevant to our search are reviewed here. RESULTS: A structurally and functionally intact choroid tissue is vitally important for the retina function. While central retinal artery is responsible to supply the 2/3, internal part of the retina, choroidal vein network is responsible for the remaining 1/3 external part...
August 1, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28760628/laparoscopic-minimally-invasive-approach-to-sentinel-lymph-node-mapping-of-the-ovary-using-the-near-infrared-fluorescent-s1-hd-pinpoint-system-with-indocyanine-green-dye
#10
Alessandro Buda, Paolo Passoni, Claudio Reato, Giampaolo Di Martino
STUDY OBJECTIVE: To show a novel minimally invasive approach to sentinel lymph node (SLN) detection of the ovary with the near-infrared guided-surgery using indocyanine green (ICG). DESIGN: step by step description of the technique with video and figures (educational video). SETTING: The standard surgical staging of early stage I-II ovarian cancer include systematic pelvic and aortic lymphadenectomy, even in the absence of clear evidence regarding the survival benefits associated with comprehensive retroperitoneal staging...
July 28, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28755860/dynamic-and-accurate-assessment-of-acetaminophen-induced-hepatotoxicity-by-integrated-photoacoustic-imaging-and-mechanistic-biomarkers-in-vivo
#11
Nathalie Brillant, Mohamed Elmasry, Neal C Burton, Josep Monne Rodriguez, Jack W Sharkey, Stephen Fenwick, Harish Poptani, Neil R Kitteringham, Christopher E Goldring, Anja Kipar, B Kevin Park, Daniel J Antoine
The prediction and understanding of acetaminophen (APAP)-induced liver injury (APAP-ILI) and the response to therapeutic interventions is complex. This is due in part to sensitivity and specificity limitations of currently used assessment techniques. Here we sought to determine the utility of integrating translational non-invasive photoacoustic imaging of liver function with mechanistic circulating biomarkers of hepatotoxicity with histological assessment to facilitate the more accurate and precise characterization of APAP-ILI and the efficacy of therapeutic intervention...
July 26, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28755641/a-visual-guide-to-gene-optothermal-synergy-therapy-nanosystem-using-tungsten-oxide
#12
Bin Zheng, Jingya Wang, Huizhuo Pan, Hongbin Chen, Wanying Ji, Zhenyu Liao, Xiaoqun Gong, Hanjie Wang, Jin Chang
Combination of gene therapy and photothermal therapy (PTT) has drawn much attention in cancer therapy in recent years. However, this joint treatment process lacks fluorescence imaging visualization guidance that limits its clinical applications in oncotherapy. Herein, we report the use of gene therapy and tungsten oxide (W18O49, WO) synthetized with template method for combined PTT of cancer. In this system, a novel nanoplatform, with Bax gene, WO and indocyanine green (ICG) loaded in mesoporous silica nanoparticle had been successfully constructed, which was used as the near-infrared imaging-guided gene/optothermal multi-modal oncotherapy...
July 20, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28748623/photoacoustic-guided-surgery-with-indocyanine-green-coated-superparamagnetic-iron-oxide-nanoparticle-clusters
#13
Jayesh P Thawani, Ahmad Amirshaghaghi, Lesan Yan, Joel M Stein, Jessica Liu, Andrew Tsourkas
A common cause of local tumor recurrence in brain tumor surgery results from incomplete surgical resection. Adjunctive technologies meant to facilitate gross total resection have had limited efficacy to date. Contrast agents used to delineate tumors preoperatively cannot be easily or accurately used in the real-time operative setting. Although multimodal imaging contrast agents are developed to help the surgeon discern tumor from normal tissue in the operating room, these contrast agents are not readily translatable...
July 27, 2017: Small
https://www.readbyqxmd.com/read/28741043/comparison-of-near-infrared-imaging-camera-systems-for-intracranial-tumor-detection
#14
Steve S Cho, Ryan Zeh, John T Pierce, Ryan Salinas, Sunil Singhal, John Y K Lee
PURPOSE: Distinguishing neoplasm from normal brain parenchyma intraoperatively is critical for the neurosurgeon. 5-Aminolevulinic acid (5-ALA) has been shown to improve gross total resection and progression-free survival but has limited availability in the USA. Near-infrared (NIR) fluorescence has advantages over visible light fluorescence with greater tissue penetration and reduced background fluorescence. In order to prepare for the increasing number of NIR fluorophores that may be used in molecular imaging trials, we chose to compare a state-of-the-art, neurosurgical microscope (System 1) to one of the commercially available NIR visualization platforms (System 2)...
July 24, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28740077/footprint-free-human-fetal-foreskin-derived-ipscs-a-tool-for-modeling-hepatogenesis-associated-gene-regulatory-networks
#15
Peggy Matz, Wasco Wruck, Beatrix Fauler, Diran Herebian, Thorsten Mielke, James Adjaye
Induced pluripotent stem cells (iPSCs) are similar to embryonic stem cells and can be generated from somatic cells. We have generated episomal plasmid-based and integration-free iPSCs (E-iPSCs) from human fetal foreskin fibroblast cells (HFF1). We used an E-iPSC-line to model hepatogenesis in vitro. The HLCs were characterized biochemically, i.e. glycogen storage, ICG uptake and release, UREA and bile acid production, as well as CYP3A4 activity. Ultra-structure analysis by electron microscopy revealed the presence of lipid and glycogen storage, tight junctions and bile canaliculi- all typical features of hepatocytes...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28738091/the-second-window-icg-technique-demonstrates-a-broad-plateau-period-for-near-infrared-fluorescence-tumor-contrast-in-glioblastoma
#16
Ryan Zeh, Saad Sheikh, Leilei Xia, John Pierce, Andrew Newton, Jarrod Predina, Steve Cho, MacLean Nasrallah, Sunil Singhal, Jay Dorsey, John Y K Lee
INTRODUCTION: Fluorescence-guided surgery has emerged as a powerful tool to detect, localize and resect tumors in the operative setting. Our laboratory has pioneered a novel way to administer an FDA-approved near-infrared (NIR) contrast agent to help surgeons with this task. This technique, coined Second Window ICG, exploits the natural permeability of tumor vasculature and its poor clearance to deliver high doses of indocyanine green (ICG) to tumors. This technique differs substantially from established ICG video angiography techniques that visualize ICG within minutes of injection...
2017: PloS One
https://www.readbyqxmd.com/read/28732936/oxygen-and-indocyanine-green-loaded-microparticles-for-dual-mode-imaging-and-sonodynamic-treatment-of-cancer-cells
#17
Rong Ma, Qiang Wu, Ting Si, Shufang Chang, Ronald X Xu
Oxygen and Indocyanine Green (ICG) loaded microparticles (OI-MPs) were fabricated by a gas-driven coaxial flow focusing (CFF) process for dual-mode imaging and sonodynamic therapy (SDT). The produced OI-MPs agent showed stable optical properties, superior imaging depth in near infrared (NIR) fluorescence imaging, and enhanced acoustic contrast after ultrasound mediation. We hypothesized that encapsulating ICG and oxygen in microparticles would enhance reactive oxygen species (ROS) production in SDT. This hypothesis was validated in a cell-free environment...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732196/sam68-offers-selectively-aimed-modulation-of-transcription-in-cancer-stem-cells
#18
Kai Fu, Fengyi Wan
In this issue of Cell Chemical Biology,Benoit et al. (2017) report the selective targeting of cancer stem cells (CSCs) by the ICG-001/CWP family of molecules. Their findings reveal that Sam68 is a transcriptional modulator uniquely required for the dysregulated Wnt/β-catenin signaling in CSCs over healthy stem cells.
July 20, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28727323/indocyanine-green-near-infrared-lymphangiography-for-evaluation-of-effectiveness-of-edema-fluid-flow-under-therapeutic-compression
#19
Marzanna T Zaleska, Waldemar L Olszewski
The commonly used modalities for therapy of limb lymphedema are manual lymphatic drainage, manual devices moving edema fluid and intermittent pneumatic compression (IPC). What seems to be necessary for validation of the effect of the compression procedure is imaging of the mobilized moving edema fluid. Picture of edema fluid flow would allow the therapist to use force adjusted to the tissue volume and stiffness differing in various limb regions as well as identify sites of abundant accumulation of fluid requiring more compression...
July 20, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28721307/multispectral-fluorescence-guided-surgery-a-feasibility-study-in-a-phantom-using-a-clinical-grade-laparoscopic-camera-system
#20
Danny M van Willigen, Nynke S van den Berg, Tessa Buckle, Gijs H KleinJan, James C Hardwick, Henk G van der Poel, Fijs Wb van Leeuwen
Although the possibilities in image guided surgery are advancing rapidly, complex surgical procedures such as nerve sparing prostatectomy still lack precision regarding differentiation between diseased and delicate anatomical structures. Here, the use of complementary fluorescent tracers in combination with a dedicated multispectral fluorescence camera system could support differentiation between healthy and diseased tissue. In this study, we provide proof of concept data indicating how a modified clinical-grade fluorescence laparoscope can be used to sensitively detect white light and three fluorescent dyes (fluorescein, Cy5, and ICG) in a sequential fashion...
2017: American Journal of Nuclear Medicine and Molecular Imaging
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