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https://www.readbyqxmd.com/read/29777957/dual-ph-reduction-responsive-hybrid-polymeric-micelles-for-targeted-chemo-photothermal-combination-therapy
#1
Linhua Zhang, Yu Qin, Zhiming Zhang, Fan Fan, Chenlu Huang, Li Lu, Hai Wang, Xu Jin, Hanxue Zhao, Deling Kong, Chun Wang, Hongfan Sun, Xigang Leng, Dunwan Zhu
The combination of chemotherapy and photothermal therapy in multifunctional nanovesicles has emerged as a promising strategy to improve cancer therapeutic efficacy. Herein, we designed new pH/reduction dual-responsive and folate decorated polymeric micelles (FA Co-PMs) as theranostic nanocarrier to co-encapsulate doxorubicin (DOX) and indocyanine green (ICG) for targeted NIR imaging and chemo-photothermal combination therapy. The Co-PMs exhibited nano-sized structure (∼100 nm) with good monodispersity, high encapsulation efficiency of both ICG and DOX, triggered DOX release in response to acid pH and reduction environment, and excellent temperature conversion with laser irradiation...
May 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29777357/optimizing-the-image-of-fluorescence-cholangiography-using-icg-a-systematic-review-and-ex-vivo-experiments
#2
Jacqueline van den Bos, Fokko P Wieringa, Nicole D Bouvy, Laurents P S Stassen
BACKGROUND: Though often only briefly described in the literature, there are clearly factors that have an influence on the fluorescence intensity, and thereby the usefulness of the technique. This article aims to provide an overview of the factors influencing the fluorescence intensity of fluorescence imaging with Indocyanine green, primarily focussed on NIRF guided cholangiography. METHODS: A systematic search was conducted to gain an overview of currently used methods in NIRF imaging in laparoscopic cholecystectomies...
May 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29777008/multispectral-fluorescence-imaging-as-a-tool-to-separate-healthy-and-disease-related-lymphatic-anatomies-during-robot-assisted-laparoscopic-procedures
#3
Philippa Meershoek, Gijs H KleinJan, Matthias N van Oosterom, Esther M Wit, Danny M van Willigen, Kevin P Bauwens, Erik J van Gennep, Alexandre M Mottrie, Henk G van der Poel, Fijs van Leeuwen
To reduce the invasive nature of extended pelvic lymph node dissections (ePLND) in prostate cancer, we have developed a multicolor fluorescence guidance approach that enables the discrimination between prostate draining lymph nodes (LNs) and lower limb draining LNs. Methods: In five porcine models multispectral-fluorescence guidance was performed using da Vinci Si- and Xi-robot consoles. They received fluorescein into the lower limb(s) and indocyanine green (ICG)-nanocolloid into the prostate. Results: Fluorescein was detected in 29 LNs (average of 3...
May 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29770250/the-usefulness-of-indocyanine-green-during-surgery-for-hypervascular-posterior-fossa-tumors
#4
Takahiro Shinya, Hideki Nagamine, Ken-Ichi Sugawara, Shogo Ishiuchi
Background: Cerebral hemangioblastomas are benign tumors with abundant blood flow that occur mainly in the posterior fossa. Tumor removal en bloc is important in surgical treatment because of the risk of bleeding; however, it is actually rather difficult in practice. Therefore, we propose a surgical strategy for visualizing hypervascular tumors of the posterior fossa utilizing indocyanine green (ICG). Case Description: Case 1 involved a 48-year-old male with a history of von Hippel-Lindau (VHL) disease...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29767944/theranostic-niosomes-for-efficient-sirna-microrna-delivery-and-activatable-near-infrared-fluorescent-tracking-of-stem-cells
#5
Chuanxu Yang, Shan Gao, Ping Song, Frederik Dagnaes-Hansen, Maria Jakobsen, Jørgen Kjems
RNA interference (RNAi) mediated gene regulation in stem cells offers great potential in regenerative medicine. In this study, we developed a theranostic platform for efficient delivery of small RNAs (siRNA/miRNA) to human mesenchymal stem cells (hMSCs) to promote differentiation, and meanwhile, to specifically label the transfected cells for in vivo tracking purpose. We encapsulated indocyanine green (ICG) in a nonionic surfactant vesicle, termed "niosome", that is mainly composed of a nonionic surfactant sorbitan monooleate (Span 80) and a cationic lipid 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29767326/fluorescence-supported-lymphography-and-extended-pelvic-lymph-node-dissection-in-robot-assisted-radical-prostatectomy-a-prospective-randomized-trial
#6
Nina Natascha Harke, Michael Godes, Christian Wagner, Mustapha Addali, Bernhard Fangmeyer, Katarina Urbanova, Boris Hadaschik, Jorn H Witt
PURPOSE: To demonstrate the benefits of fluorescence-supported extended pelvic lymph node dissection (ePLND) compared to regular ePLND in robot-assisted radical prostatectomy. METHODS: 120 patients with intermediate- or high-risk prostate cancer were prospectively randomized (1:1): in the intervention group, indocyanine green (ICG) was injected transrectally into the prostate before docking of the robot. In both groups, ePLND was performed including additional dissection of fluorescent lymph nodes (LN) in the ICG group...
May 16, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29762775/combination-superficial-temporal-artery-middle-cerebral-artery-bypass-and-m2-m2-reanastomosis-with-trapping-of-a-stented-distal-middle-cerebral-artery-aneurysm-3-dimensional-operative-video
#7
Jan-Karl Burkhardt, Sonia Yousef, Halima Tabani, Arnau Benet, Roberto Rodriguez Rubio, Michael T Lawton
Distal middle cerebral artery (MCA) aneurysms often have non-saccular morphology and cannot be clipped, requiring revascularization and trapping instead. Combination bypasses are needed when 2 arteries exit the aneurysm, and extracranial-intracranial and intracranial-intracranial bypasses can be used. This video demonstrates a combination bypass used to treat a previously stented distal MCA aneurysm with both a superficial temporal artery (STA)-to-MCA bypass and an M2-to-M2 reanastomosis. This 56-yr-old man presented with distal left-sided MCA aneurysm 2 years earlier and attempted stent-assisted coiling was aborted after the aneurysm was perforated with stenting alone...
May 12, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29760983/performance-of-optoacoustic-and-fluorescence-imaging-in-detecting-deep-seated-fluorescent-agents
#8
Zhenyue Chen, Xosé Luís Deán-Ben, Sven Gottschalk, Daniel Razansky
Fluorescent contrast agents are widely employed in biomedical research. While many studies have reported deep tissue imaging of fluorescent moieties using either fluorescence-based or absorption-based (optoacoustic) imaging systems, no systematic comparison has been performed regarding the actual performance of these imaging modalities in detecting deep-seated fluorescent agents. Herein, an integrated imager combining epi-fluorescence and volumetric optoacoustic imaging capabilities has been employed in order to evaluate image degradation with depth for several commonly-used near-infrared dyes in both modes...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29758552/downregulation-of-s100a4-alleviates-cardiac-fibrosis-via-wnt-%C3%AE-catenin-pathway-in-mice
#9
LiJun Qian, Jian Hong, YanMei Zhang, MengLin Zhu, XinChun Wang, YanJuan Zhang, Ming Chu, Jing Yao, Di Xu
BACKGROUND/AIMS: Cardiac fibrosis is a pathological change leading to cardiac remodeling during the progression of myocardial ischemic diseases, and its therapeutic strategy remains to be explored. S100A4, a calcium-binding protein, participates in fibrotic diseases with an unclear mechanism. This study aimed to investigate the role of S100A4 in cardiac fibrosis. METHODS: Cardiac fibroblasts from neonatal C57BL/6 mouse hearts were isolated and cultured. Myocardial infarction was induced by ligating the left anterior descending coronary artery (LAD)...
May 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29753852/color-fundus-photography-optical-coherence-tomography-and-fluorescein-angiography-in-diagnosing-polypoidal-choroidal-vasculopathy
#10
Voraporn Chaikitmongkol, Preeyanuch Khunsongkiet, Direk Patikulsila, Mansing Ratanasukon, Nawat Watanachai, Chaisiri Jumroendararasame, Catherine B Mayerle, Ian C Han, Connie J Chen, Pawara Winaikosol, Chutikarn Dejkriengkraikul, Janejit Choovuthayakorn, Paradee Kunavisarut, Neil M Bressler
PURPOSE: To determine sensitivity and specificity of polypoidal choroidal vasculopathy (PCV) diagnosis using color fundus photography (CFP), optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) without indocyanine-green angiography (ICGA). DESIGN: Validity analysis. METHODS: Treatment-naïve eyes with serous/serosanguinous maculopathy undergoing CFP, OCT, FFA and ICGA imaging before treatment at a university-hospital in Thailand (January 2013 to June 2015) were identified...
May 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29747235/pure-laparoscopic-hepatectomy-with-augmented-reality-assisted-indocyanine-green-fluorescence-versus-open-hepatectomy-for-hepatocellular-carcinoma-with-liver-cirrhosis-a-propensity-analysis-at-a-single-center
#11
Tan To Cheung, Ka Wing Ma, Wong Hoi She, Wing Chiu Dai, Simon Hing Yin Tsang, Albert Chi Yan Chan, Kenneth Siu Ho Chok, Chung Mau Lo
INTRODUCTION: Laparoscopic hepatectomy is considered an acceptable treatment of choice in selected patients with primary hepatocellular carcinoma (HCC). Whether indocyanine green (ICG) immunofluorescence, a new technology, may improve surgery outcomes has yet to be tested. The aim of the present study was to investigate and compare the effect of ICG fluorescence imaging on the outcomes of pure laparoscopic hepatectomy and open hepatectomy for primary HCC with background cirrhosis. METHODS: From January 2015 to June 2016, 20 patients with HCC and liver cirrhosis underwent laparoscopic hepatectomy with ICG immunofluorescence...
May 10, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29747142/risk-factors-for-the-failure-of-iliococcygeus-suspension-for-uterine-prolapse
#12
Dong Hoon Suh, Myung Jae Jeon
OBJECTIVES: The objective of this study was to evaluate the risk factors for the failure of iliococcygeus suspension (ICG) for uterine prolapse and estimate its long-term success rates using a clinically relevant criterion. STUDY DESIGN: This retrospective cohort study included 144 women who underwent transvaginal reconstructive surgery including ICG for symptomatic pelvic organ prolapse. Surgical failure was defined as anatomic recurrence (descent of the vaginal apex beyond the halfway point of the vagina or descent of the anterior or posterior vaginal wall beyond the hymen), symptomatic recurrence (vaginal bulge symptoms), or retreatment for prolapse...
May 2, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29745953/targeted-polypyrrole-nanoparticles-for-the-identification-and-treatment-of-hepatocellular-carcinoma
#13
Yushen Jin, Xin Yang, Jie Tian
Early identification and treatment of hepatocellular carcinoma is very important for improving the prognosis and survival rate of the patient. To enhance the visualization and treatment efficiency of HCC, a theranostic agent has been developed that combines photoacoustic/fluorescence imaging with photothermal therapy for cancer. We report the synthesis of multifunctional theranostic SP94-modified polypyrrole (PPy)-BSA-ICG nanoparticles by a simple method. The multifunctional theranostic agent helped to combine two modes of imaging modalities, i...
May 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29745622/noninvasive-assessment-of-cardiac-index-using-impedance-cardiography-during-liver-transplantation-surgery-a-comparison-with-pulmonary-artery-thermodilution
#14
Vlad Suparschi, Eric Le Bihan, Amélie Toussaint, Diana Saptefrat, Heykel Ben Abdallah, Faouzi Gloulou, Farida Aouati, Tobias Gauss, Catherine Paugam-Burtz
BACKGROUND: Liver Transplantation (LT) is a high-risk surgery associated with significant hemodynamic changes requiring advanced hemodynamic monitoring. Pulmonary Artery Catheter (PAC) is still considered as a gold-standard for cardiac index (CI) measurement during LT despite association with an increased risk of complications. Noninvasive impedance cardiography (ICG) could be an interesting alternative tool for CI monitoring. The aim of this study was to compare the precision and trending ability of ICG versus PAC methods during LT...
May 9, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29744752/indocyanine-green-mediated-photobiomodulation-on-human-osteoblast-cells
#15
Gamze Bölükbaşı Ateş, Ayşe Ak, Bora Garipcan, Murat Gülsoy
Photobiomodulation (PBM) and photodynamic therapy (PDT) share similar mechanisms but have opposite aims. Increased levels of reactive oxygen species (ROS) in the target tissue in response to light combined photosensitizer (PS) application may lead to cell proliferation or oxidative damage depending on the ROS amount. The purpose of the present study is to investigate the effect of indocyanine green (ICG)-mediated PBM on osteoblast cells by measuring cell viability, proliferation, alkaline phosphatase (ALP) activity, mineralization, and gene expressions of three phenotypic osteoblast markers...
May 9, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29744048/icg-easily-detects-not-only-the-segmental-plane-but-also-the-course-and-blood-distribution-of-the-bronchial-artery-case-report
#16
Hidetaka Uramoto, Nozomu Motono
Introduction: Sublobar resection has become an acceptable alternative to lobectomy in patients with early-stage lung cancer. Most notable among these approaches is indocyanine green fluorescence (ICG) imaging. Case presentation: Operative finding showed clear green staining of the left upper lobe, S6, superior pulmonary vein, and inferior PV under fluorescence navigation. Soon, the bronchial artery of right lower bronchus showed clear green staining. Next, the whole right lower bronchus is deeply colored green...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29743794/role-of-indocyanine-green-in-predicting-post-transarterial-chemoembolization-liver-failure-in-hepatocellular-carcinoma
#17
Shalimar, Sushil Jain, Shivanand R Gamanagatti, Saurabh Kedia, Bhaskar Thakur, Baibaswata Nayak, Harpreet Kaur, Deepak Gunjan, Shashi B Paul, Subrat K Acharya
Background/aim: Post-Transarterial Chemoembolization (TACE) Liver Failure (LF) is common in patients with Hepatocellular Carcinoma (HCC). No definitive objective parameters predict its occurrence. We assessed the role of Indocyanine Green (ICG) in prediction of post-TACE LF. Methods: Consecutive HCC patients with Child A/B class, categorized as Barcelona Clinic Liver Cancer (BCLC) staging A/B, were included between August 2012 and July 2014. All underwent ICG dynamics: Plasma Disappearance Rate (PDR) was recorded on the day of TACE...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743483/confirmation-of-brain-death-using-optical-methods-based-on-tracking-of-an-optical-contrast-agent-assessment-of-diagnostic-feasibility
#18
Wojciech Weigl, Daniel Milej, Anna Gerega, Beata Toczyłowska, Piotr Sawosz, Michał Kacprzak, Dariusz Janusek, Stanisław Wojtkiewicz, Roman Maniewski, Adam Liebert
We aimed to determine whether optical methods based on bolus tracking of an optical contrast agent are useful for the confirmation of cerebral circulation cessation in patients being evaluated for brain death. Different stages of cerebral perfusion disturbance were compared in three groups of subjects: controls, patients with posttraumatic cerebral edema, and patients with brain death. We used a time-resolved near-infrared spectroscopy setup and indocyanine green (ICG) as an intravascular flow tracer. Orthogonal partial least squares-discriminant analysis (OPLS-DA) was carried out to build statistical models allowing for group separation...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742652/the-use-of-a-honeycomb-technique-combined-with-ultrasonic-aspirators-and-indocyanine-green-fluorescence-angiography-for-a-superthin-anterolateral-thigh-flap-a-pilot-study
#19
Song Fan, Han-Qing Zhang, Qun-Xing Li, Tian Tian, Wei-Xiong Chen, Guo-Kai Pan, Michael Ho-Young Ahn, Sheng Sun, Bing-Hao Wu, Jin-Song Li
BACKGROUND: Harvesting an optimally thinned anterolateral thigh flaps (ALTFs) is a challenge in overweight individuals and in the Western population. Here, we describe a novel honeycomb technique to achieve a superthin ALTF in overweight patients. METHODS: Forty patients with a body mass index(BMI) >25 kg/m who required a thinned ALTF for reconstruction were randomly assigned to a honeycomb technique (HCT) group or a microdissection technique (MDT) group. Patients in the HCT group received cavitron ultrasonic surgical aspiration (CUSA) to thin the flaps, and flap thinning was performed with a conventional MDT in the MDT group...
May 2, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29734009/folic-acid-modified-cell-membrane-capsules-encapsulated-doxorubicin-and-indocyanine-green-for-highly-effective-combinational-therapy-in-vivo
#20
Xiao Li, Xinlian Zhao, Dinesh Pardhi, Qianqian Wu, Yong Zheng, Huihui Zhu, Zhengwei Mao
A combination of chemotherapy and phototherapy has emerged as a promising strategy for cancer treatment. To achieve effective combinational therapy of cancer with reduced toxicity, it is highly desirable to improve the targeting of chemotherapeutic and near-infrared photosensitizers to enhance their accumulation in tumor. Here we report a novel tumor targeting cell membrane capsule (CMC), originate from living cells, to load doxorubicin hydrochloride (DOX) and indocyanine green (ICG), for combinational photo-chemotherapy against cancer...
May 4, 2018: Acta Biomaterialia
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