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https://www.readbyqxmd.com/read/28316935/anaphylactic-shock-after-intravenous-administration-of-indocyanine-green-during-robotic-partial-nephrectomy
#1
William Chu, Avinash Chennamsetty, Robert Toroussian, Clayton Lau
Indocyanine Green (ICG) is frequently used during urologic robotic procedures and is generally considered to be safe. However, there are reported cases of severe complications from ICG when used for non-urologic purposes. We present the first case to our knowledge of anaphylactic shock in response to intravenous ICG during a robotic partial nephrectomy.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28315801/use-of-indocyanine-green-fluorescence-endoscopy-to-treat-concurrent-perimedullary-and-dural-arteriovenous-fistulas-in-the-cervical-spine
#2
Akira Ito, Toshiki Endo, Tomoo Inoue, Hidenori Endo, Kenichi Sato, Teiji Tominaga
BACKGROUND: Intraoperative microscopic fluorescence angiography using indocyanine green (ICG) provides visual information on real-time blood flow. However, this method cannot be applied for lesions that are not visible under microscopic imaging because excitation light does not reach the targeted vascular structures. Endoscope-integrated ICG video-angiography has recently been advocated to compensate for this limitation. This is the first reported case of a spinal arteriovenous malformation in which endoscope-integrated ICG video-angiography was successfully used...
March 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28306236/hydrophobic-ir-780-dye-encapsulated-in-crgd-conjugated-solid-lipid-nanoparticles-for-nir-imaging-guided-photothermal-therapy
#3
Ye Kuang, Kunchi Zhang, Yi Cao, Xing Chen, Kewei Wang, Min Liu, Renjun Pei
It is highly demanded to improve the accumulation of NIR theranostic agents in tumor region, which is favorable to the effective phototherapy. IR-780 iodide, a near-infrared (NIR) fluorescence dye, possesses higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG), and can be utilized in imaging-guided photothermal therapy with laser irradiation. However, lipophilicity, short circulation time and lack of targeting specificity limit its applications in cancer imaging and therapy...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28302627/inhibition-of-smooth-muscle-%C3%AE-catenin-hinders-neointima-formation-after-vascular-injury
#4
Dario F Riascos-Bernal, Prameladevi Chinnasamy, Jordana N Gross, Vanessa Almonte, Lander Egaña-Gorroño, Dippal Parikh, Smitha Jayakumar, Liang Guo, Nicholas E S Sibinga
OBJECTIVE: Smooth muscle cells (SMCs) contribute to neointima formation after vascular injury. Although β-catenin expression is induced after injury, whether its function is essential in SMCs for neointimal growth is unknown. Moreover, although inhibitors of β-catenin have been developed, their effects on SMC growth have not been tested. We assessed the requirement for SMC β-catenin in short-term vascular homeostasis and in response to arterial injury and investigated the effects of β-catenin inhibitors on vascular SMC growth...
March 16, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28292878/pneumonia-treatment-by-photodynamic-therapy-with-extracorporeal-illumination-an-experimental-model
#5
Mariana C Geralde, Ilaiáli S Leite, Natalia M Inada, Ana Carolina G Salina, Alexandra I Medeiros, Wolfgang M Kuebler, Cristina Kurachi, Vanderlei S Bagnato
Infectious pneumonia is a major cause of morbidity/mortality, mainly because of the increasing rate of microorganisms resistant to antibiotics. Photodynamic Therapy (PDT) is emerging as a promising approach, as effects are based on oxidative stress, preventing microorganism resistance. In two previous studies, the in vitro inactivation of Streptococcus pneumoniae using indocyanine green (ICG) and infrared light source was a success killing 5 log10 colony-forming units (CFU/mL) with only 10 μmol/L ICG. In this work, a proof-of-principle protocol was designed to treat lung infections by PDT using extracorporeal illumination with a 780 nm laser device and also ICG as photosensitizer...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28292569/indocyanine-green-applications-in-plastic-surgery-a-review-of-the-literature
#6
Pierre Burnier, Jérémy Niddam, Romain Bosc, Barbara Hersant, Jean-Paul Meningaud
INTRODUCTION: Use of indocyanine green (ICG) near-infrared fluorescence as a dye to assess tissue vascularization is now well standardized. The aim of this literature review was to review and resume the most recent recommendations for ICG use in its plastic surgery applications. METHODS: A systematic literature review was performed using Medline, EMBASE, and PubMed databases to obtain the latest recommendations for ICG in plastic surgery. Inclusion criteria were all articles written in English language that evaluated pre-, intra-, or postoperative ICG applications in surgical procedures usually performed by plastic surgeons...
February 20, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28281123/icg-fluorescence-imaging-for-quantitative-evaluation-of-colonic-perfusion-in-laparoscopic-colorectal-surgery
#7
Toshiaki Wada, Kenji Kawada, Ryo Takahashi, Mami Yoshitomi, Koya Hida, Suguru Hasegawa, Yoshiharu Sakai
BACKGROUND: Fluorescence technology with indocyanine green (ICG) provides a real-time assessment of intestinal perfusion. However, a subjective evaluation of fluorescence intensity based on the surgeon's visual judgement is a major limitation. This study evaluated the quantitative assessment of ICG fluorescence imaging in determining the transection line of the proximal colon during laparoscopic colorectal surgery. METHODS: This is a retrospective analysis of a prospectively maintained database of 112 patients who underwent laparoscopic surgery for left-sided colorectal cancers...
March 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28277591/the-role-of-fluorescent-angiography-in-anastomotic-leaks
#8
Sarath Sujatha-Bhaskar, Mehraneh D Jafari, Michael J Stamos
Anastomotic leaks following colorectal anastomosis has substantial implications including increased morbidity, longer hospitalization, and reduced overall survival. The etiology of leaks includes patient factors, technical factors, and anastomotic perfusion. An intact anastomotic blood supply is especially crucial in the physiology of anastomotic healing. To date, no established intraoperative methods have been developed that reliably and reproducibly identify and prevent leak occurrence. Recently, fluorescent angiography (FA) with indocyanine green (ICG) has emerged as an innovative modality for intraoperative perfusion assessment...
March 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28277002/folate-modified-indocyanine-green-loaded-lipid-polymer-hybrid-nanoparticles-for-targeted-delivery-of-cisplatin
#9
Lianshuai Gu, Tianyi Shi, Yu Sun, Chaoqun You, Senlin Wang, Gaoju Wen, Lan Chen, Xiangyang Zhang, Jin Zhu, Baiwang Sun
Cisplatin is a potent antitumor drug, which is widely applied in clinical cancer treatment. However, cisplatin can hardly distinguish between healthy tissue and tumor tissue, resulting in serious toxic side effects. Indocyanine green (ICG) is a FDA-approved near-infrared (NIR) fluorescence dye which has been used in photothermal therapy and optically mediated diagnostic, but the application of ICG is limited by its concentration-dependent aggregation, poor aqueous stability in vitro, lack of target specificity and rapid elimination from the body...
May 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28276723/detection-of-blood-volumes-and-haemoglobin-mass-by-means-of-co-re-breathing-and-indocyanine-green-and-sodium-fluorescein-injections
#10
Stefanie Keiser, Anne-Kristine Meinild-Lundby, Thomas Steiner, Severin Trösch, Sven Rauber, Alexander Krafft, Tilo Burkhardt, Matthias Peter Hilty, Christoph Siebenmann, Jon Peter Wehrlin, Carsten Lundby
The main aim of the present study was to quantify the magnitude of differences introduced when estimating a given blood volume compartment (e.g. plasma volume) through the direct determination of another compartment (e.g. red cell volume) by multiplication of venous haematocrit and/or haemoglobin concentration. However, since whole body haematocrit is higher than venous haematocrit such an approach might comprise certain errors. To test this experimentally, four different methods for detecting blood volumes and haemoglobin mass (Hbmass) were compared, namely the carbon monoxide (CO) re-breathing (for Hbmass), the indocyanine green (ICG; for plasma volume [PV]) and the sodium fluorescein (SoF; for red blood cell volume [RBCV]) methods...
May 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28272929/perfusion-of-the-rotator-cuff-tendon-according-to-the-repair-configuration-using-an-indocyanine-green-fluorescence-arthroscope
#11
Sae Hoon Kim, Won-Sang Cho, Ho-Yun Joung, Young Eun Choi, Minwoong Jung
BACKGROUND: The disturbance of rotator cuff tendon perfusion has been connected with the suture-bridge configuration repair (SBCR) technique; however, in vivo assessments of the tendon blood supply have been problematic with other modalities. An evaluation of tissue perfusion by an indocyanine green (ICG) fluorescence arthroscope has been developed to counteract this difficulty. PURPOSE: To verify the hindrance of perfusion in SBCR, we used an ICG fluorescence camera to compare parallel-type transosseous repair (PTR) and SBCR in rabbits immediately and at 3 days after rotator cuff repair...
March 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28271266/near-infrared-fluorescence-laparoscopy-of-the-cystic-duct-and-cystic-artery-first-experience-with-two-new-preclinical-dyes-in-a-pig-model
#12
Jacqueline van den Bos, Mahdi Al-Taher, Shu Gi Hsien, Nicole D Bouvy, Laurents P S Stassen
BACKGROUND: Imaging techniques that enhance visualisation of the anatomy may help prevent bile duct injury. Near-Infrared Fluorescence Imaging is such a technique. Previous experiments with ICG have shown that illumination of the extra-hepatic bile ducts is feasible. Yet, there is room for improvement in the visualisation of the target as compared to the background. Experiments with IRDye(®) 800CW show promising results. However, this dye is too expensive for routine clinical use. The aim of this study is to test the first applicability of two newly developed preclinical dyes regarding intraoperative imaging of the cystic duct and cystic artery, compared with IRDye(®) 800CW...
March 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28271001/fully-integrated-optical-coherence-tomography-ultrasound-and-indocyanine-green-based-fluorescence-tri-modality-system-for-intravascular-imaging
#13
Yan Li, Joseph Jing, Yueqiao Qu, Yusi Miao, Buyun Zhang, Teng Ma, Mingyue Yu, Qifa Zhou, Zhongping Chen
We present a tri-modality imaging system and fully integrated tri-modality probe for intravascular imaging. The tri-modality imaging system is able to simultaneously acquire optical coherence tomography (OCT), ultrasound (US), and fluorescence imaging. Moreover, for fluorescence imaging, we used the FDA-approved indocyanine green (ICG) dye as the contrast agent to target lipid-loaded macrophages. We conducted imaging from a male New Zealand white rabbit to evaluate the performance of the tri-modality system...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28270983/clinically-compatible-flexible-wide-field-multi-color-fluorescence-endoscopy-with-a-porcine-colon-model
#14
Gyugnseok Oh, Youngrong Park, Su Woong Yoo, Soonjoo Hwang, Alexey V Dan Chin-Yu, Yeon-Mi Ryu, Sang-Yeob Kim, Eun-Ju Do, Ki Hean Kim, Sungjee Kim, Seung-Jae Myung, Euiheon Chung
Early detection of structural or molecular changes in dysplastic epithelial tissues is crucial for cancer screening and surveillance. Multi-targeting molecular endoscopic fluorescence imaging may improve noninvasive detection of precancerous lesions in the colon. Here, we report the first clinically compatible, wide-field-of-view, multi-color fluorescence endoscopy with a leached fiber bundle scope using a porcine model. A porcine colon model that resembles the human colon is used for the detection of surrogate tumors composed of multiple biocompatible fluorophores (FITC, ICG, and heavy metal-free quantum dots (hfQDs))...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28269438/a-novel-wireless-wearable-fluorescence-image-guided-surgery-system
#15
Kunshan He, Yamin Mao, Jinzuo Ye, Yu An, Shixin Jiang, Chongwei Chi, Jie Tian
Segmentectomy using indocyanine green (ICG) has become a primary treatment option to achieve a complete resection and preserve lung function in early-stage lung cancer. However, owing to a lack of appropriate intraoperative imaging systems, it is a huge challenge for surgeons to identify the intersegmental plane during the operation, leading to poor prognosis. Thus, we developed a novel wireless wearable fluorescence image-guided surgery system (LIGHTEN) for fast and accurate identification of intersegmental planes in human patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266528/gd-eob-dtpa-enhanced-mri-for-evaluation-of-liver-function-comparison-between-signal-intensity-based-indices-and-t1-relaxometry
#16
Michael Haimerl, Niklas Verloh, Florian Zeman, Claudia Fellner, Dominik Nickel, Sven A Lang, Andreas Teufel, Christian Stroszczynski, Philipp Wiggermann
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. In this paper we compare the diagnostic performance of Gd-EOB-DTPA-enhanced relaxometry-based and commonly used signal-intensity (SI)-based indices, including the hepatocellular uptake index (HUI) and SI-based indices corrected by spleen or muscle, for evaluation of liver function, determined using the Indocyanin green clearance (ICG) test...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28265777/a-prospective-cohort-study-comparing-colorimetric-and-fluorescent-imaging-for-sentinel-lymph-node-mapping-in-endometrial-cancer
#17
Robert W Holloway, Sarfraz Ahmad, James E Kendrick, Glenn E Bigsby, Lorna A Brudie, Giselle B Ghurani, Nicole M Stavitzski, Jasmine L Gise, Susan B Ingersoll, Julie W Pepe
BACKGROUND: This prospective cohort study aimed to assess sentinel lymph node (SLN) mapping using isosulfan blue (ISB) compared with ISB plus indocyanine green (ICG) and near-infrared imaging (NIR) for patients with endometrial cancer. METHODS: In this study, 200 patients with endometrial cancer underwent SLN assessments and were randomized to ISB + ICG (n = 180) or ISB alone (n = 20). Blue dye determinations were recorded for all 200 cases followed by NIR imaging of ICG for 180 randomized subjects...
March 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28265729/quality-control-of-the-foot-revascularization-using-indocyanine-green-fluorescence-imaging
#18
Nicla Settembre, Petteri Kauhanen, Anders Albäck, Kristyna Spillerova, Maarit Venermo
OBJECTIVES: Critical limb ischemia (CLI) is a clinical diagnosis, confirmed by objective tests, usually ankle-brachial index (ABI), toe pressure (TP) and TcPO2. Furthermore, the anatomical lesions in patients affected by CLI were visualized by ultrasound, angiography, CTA, or MRA. Indocyanine green fluorescence imaging (ICG-FI) is a diagnostic modality for assessing foot perfusion. We aimed to study the usefulness of ICG-FI in the quality control of revascularization. MATERIALS AND METHODS: One hundred and four CLI limbs in 101 patients were studied with ICG-FI using SPY Elite before and after open or endovascular revascularization...
March 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28261693/risk-factors-of-postoperative-ascites-on-hepatic-resection-for-hepatocellular-carcinoma
#19
Seong Woon Choi, Woo Young Shin, Keon Young Lee, Seung Ik Ahn
BACKGROUNDS/AIMS: The aim of this study was to identify the risk factors of the development of large amounts of ascites (LA) after hepatic resection for hepatocellular carcinoma (HCC). METHODS: The medical records of 137 consecutive patients who underwent hepatic resection for HCC from January 2010 to December 2014 were retrospectively reviewed. Patients were divided into two groups: LA group, with ascites drainage >500 cc per day over 3 days (n=37) and control group (n=100)...
November 2016: Ann Hepatobiliary Pancreat Surg
https://www.readbyqxmd.com/read/28258529/human-umbilical-cord-mesenchymal-stem-cells-alleviate-inflammatory-bowel-disease-through-the-regulation-of-15-lox-1-in-macrophages
#20
Fei Mao, Yunbing Wu, Xudong Tang, Juanjuan Wang, Zhaoji Pan, Peng Zhang, Bin Zhang, Yongmin Yan, Xu Zhang, Hui Qian, Wenrong Xu
OBJECTIVE: To investigate the role of human umbilical cord mesenchymal stem cells (hucMSCs) in the treatment of dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD). RESULTS: ICG-hucMSCs homed to colon tissues of IBD mice 12 h after injection. The injection of hucMSCs significantly relieved the IBD symptoms and inflammatory cell infiltration. The expression of IL-10 gene increased while those of 15-LOX-1, TNF-α, IL-6, IL-1β, and IP-10 genes decreased in colon tissues and spleens of hucMSCs-treated mice...
March 3, 2017: Biotechnology Letters
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