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N Biglia, V E Bounous, M Gallo, L Fuso, L G Sgro, F Maggiorotto, R Ponzone
OBJECTIVES: To investigate the role and feasibility of sentinel lymph node biopsy (SLNB) in breast cancer patients with a local recurrence and no clinically positive axillary lymph nodes. MATERIALS AND METHODS: A total of 71 patients underwent SLNB for breast cancer recurrence. At first surgery, they had received SLNB (46.5%), axillary lymph node dissection (ALND) (36.6%) or no axillary surgery (16.9%). RESULTS: Lymphatic migration was successful in 53 out of 71 patients (74...
June 7, 2018: Breast: Official Journal of the European Society of Mastology
David H Smith, Susan Shetterly, James Flory, Kevin Haynes, Christine Y Lu, Joshua J Gagne, Lisa Herrinton, Carsie Nyirenda, Elisabetta Patorno, Azadeh Shoaibi, Marsha A Raebel
PURPOSE: In this report, we use data from FDA's Sentinel System to focus on how augmenting a diagnosis-based chronic kidney disease cohort with patients identified through laboratory results impacts cohort characteristics and outcomes. METHODS: We used data from 2 Data Partners. Patients were eligible if they were health plan members on January 1, 2012. We classified chronic kidney disease patients into mutually exclusive categories according to the hierarchy of (1) ICD-9-CM diagnosis (DXGroup), or (2) two estimated glomerular filtration rates <60 mL/min/1...
June 22, 2018: Pharmacoepidemiology and Drug Safety
Huan-Cheng Zeng, Jia-Lin Hu, Jing-Wen Bai, Guo-Jun Zhang
Optical molecular imaging, a highly sensitive and noninvasive technique which is simple to operate, inexpensive, and has the real-time capability, is increasingly being used in the diagnosis and treatment of carcinomas. The near-infrared fluorescence dye indocyanine green (ICG) is widely used in optical imaging for the dynamic detection of sentinel lymph nodes (SLNs) in real time improving the detection rate and accuracy. ICG has the advantages of low scattering in tissue absorbance, low auto-fluorescence, and high signal-to-background ratio...
June 21, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Brian Rha, Rebecca M Dahl, Jocelyn Moyes, Alison M Binder, Stefano Tempia, Sibongile Walaza, Daoling Bi, Michelle J Groome, Ebrahim Variava, Fathima Naby, Kathleen Kahn, Florette Treurnicht, Adam L Cohen, Susan I Gerber, Shabir A Madhi, Cheryl Cohen
Background: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection (ALRTI) in young children, but data on surveillance case definition performance in estimating burdens have been limited. Methods: We enrolled children aged <5 years hospitalized for ALRTI (or neonatal sepsis in young infants) through active prospective surveillance at 5 sentinel hospitals in South Africa and collected nasopharyngeal aspirates from them for RSV molecular diagnostic testing between 2009 and 2014...
June 21, 2018: Journal of the Pediatric Infectious Diseases Society
Lisa M Rogers, Jennifer A Gaddy, Shannon D Manning, David M Aronoff
Background: Group B Streptococcus (GBS) is an encapsulated Gram-positive coccus that is an important cause of infections in adults with chronic medical conditions, pregnant women, and neonates. GBS causes a range of clinical syndromes, from asymptomatic colonization to deep-seated invasive and highly lethal infections. Macrophages are important sentinels of innate immunity, protecting host tissues from infection when bacteria advance beyond cutaneous or mucosal barriers. We hypothesized that the capacity for macrophages to phagocytose unopsonized GBS would vary across distinct clinical strains, and such differences would reflect serotype diversity...
2018: Pathogens & Immunity
J de Boniface, J Frisell, L Bergkvist, Y Andersson
BACKGROUND: The prognostic equivalence between mastectomy and breast-conserving surgery (BCS) followed by radiotherapy was shown in pivotal trials conducted decades ago. Since then, detection and treatment of breast cancer have improved substantially and recent retrospective analyses point towards a survival benefit for less extensive breast surgery. Evidence for the association of such survival data with locoregional recurrence rates is largely lacking. METHODS: The Swedish Multicentre Cohort Study prospectively included clinically node-negative patients with breast cancer who had planned sentinel node biopsy between 2000 and 2004...
June 21, 2018: British Journal of Surgery
Anne-Floor W Pouwer, Roel D M Mus, Joanna IntHout, Ate G J van der Zee, Johan Bulten, Leon F A G Massuger, Joanne A de Hullu
OBJECTIVE: To determine the efficacy of the addition of an ultrasound of the groins in routine follow-up of patients with vulvar squamous cell carcinoma (SCC) after a negative sentinel lymph node (SLN). DESIGN: Prospective single center study. SETTING: A tertiary expert oncology center for the treatment of vulvar cancer. POPULATION: All vulvar SCC patients with a negative SLN, treated between 2006 and 2014. METHODS: We prospectively collected data of 139 vulvar SCC patients treated with a SLN procedure...
June 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Tariane Friedrich Foiato, Bruno Rafael Kunz Bereza, Marcos Flávio Montenegro, Marina Riedi Guilherme, Larissa Beatriz Volski, Juliano Camargo Rebolho
BACKGROUND: Melanoma is one of the conditions with greater increase in incidence worldwide in recent decades. It is a skin cancer with potential high lethality and predominates in Caucasian adults. Treatment of primary cutaneous melanoma is essentially surgical and search for sentinel lymph node can modify the aggressiveness of the treatment. OBJECTIVE: To analyze the epidemiological profile of patients diagnosed with primary cutaneous melanoma, histopathological features and compare with literature data...
June 2018: Anais Brasileiros de Dermatologia
Linn Woelber, Simon A Joosse, Donata Grimm, Sabrina Mathey, Sven Mahner, Eike Burandt, Susanne Klutmann, Barbara Schmalfeldt, Katharina Prieske
OBJECTIVE: Sentinel node biopsy (SNB) has become standard of care in early stage vulvar cancer. As the correlation of isotope count with the presence of metastases remains unclear, often several active nodes are excised per groin. This can result in increased morbidity in node-negative disease despite of SNB. In the current analysis, we assess whether resection of the hottest node could be sufficient to detect sentinel lymph node (SLN) metastasis. METHODS: Patients with primary vulvar cancer receiving an SNB with radioactive tracer at the University Medical Center Hamburg-Eppendorf between 2008 and 2015 were evaluated...
June 19, 2018: International Journal of Gynecological Cancer
Bhavna Sangal, Pradeep Kumar, Neeraj Dhingra
We aim to describe trends in antenatal HIV prevalence in India, at a national and regional level from consistent sentinel surveillance sites (2003-2015) among Antenatal Clinic (ANC) attendees. Data were analyzed from a total of 1,885,207 ANC attendees recruited at ANC sites. The consistent sites were grouped by years of initiation (Group 1: 2003-2005 and Group 2: 2006-2008) and according to six regions. Chi-square test for linear trend was applied to test the statistical significance of the trend. Nationally, at Group 1 sites, HIV prevalence was 0...
April 2018: Indian Journal of Public Health
S G Keohane, C M Proby, C Newlands, R J Motley, I Nasr, M F Mohd Mustapa, D N Slater
The 8th edition of TNM (Tumour, Node and Metastasis) has numerous and important changes compared to the 7th edition. Public Health England (PHE) and the Royal College of Pathologists, United Kingdom (RCPath) have adopted the 8th edition of TNM (TNM8) published by the Union for International Cancer Control (UICC) for skin cancer staging. These changes will have an impact on the management of both non-melanoma and melanoma skin cancer by all members of the skin cancer multidisciplinary team. These will also need to be highlighted to commissioners and managers for appropriate service planning...
June 19, 2018: British Journal of Dermatology
D Kowalczyk, K Szymański, K Cieślak, E Hallmann-Szelińska, L B Brydak
Influenza viruses cause respiratory infections every epidemic season regardless of the patient's age. The aim of this study was to determine the activity of respiratory viruses in the epidemic season 2016/2017 in Poland, with particular emphasis on influenza viruses among people aged over 14. There were 2982 clinical samples taken from patients from four age groups: 15-25, 26-44, 45-64, and ≥ 65 years tested under the Sentinel and non-Sentinel surveillance programs. The presence of influenza viruses was confirmed in more than 40% of cases, the predominant type was influenza A virus unsubtyped, followed by subtype A/H3N2/...
June 20, 2018: Advances in Experimental Medicine and Biology
Shi Guo, Dan Lin, Li-Li Wang, Hong Hu
Background: To investigate the epidemiologic distribution of foodborne diseases in Wenzhou City from 2014-2015, we analyzed the characteristics and main pathogens of foodborne disease outbreaks to provide a reference for the prevention, control, and early warning of foodborne diseases. Methods: A total of 9139 patients with foodborne diseases were included in the database of active monitoring from sentinel hospitals in Wenzhou City, China. Salmonella , Shigella , Vibrio parahaemolyticus , enteropathogenic Escherichia coli, and norovirus in the stool samples collected from patients with foodborne diseases were detected according to national standards...
May 2018: Iranian Journal of Public Health
Heather Burke, Agnieszka Boron, Jung-Hyun Lee, Kudrit Riana Kahlon
Transcatheter aortic valve replacement (TAVR) is a newer alternative to surgical aortic valve replacement (SAVR) for patients with severe aortic stenosis. Clinical trials have investigated TAVR's safety and effectiveness. Cerebral embolization is a common complication leading to stroke after TAVR and SAVR; different cerebral protection methods have been studied to prevent this. This paper evaluates the rate of post-procedural stroke rates between TAVR and SAVR and investigates the effect of cerebral protective methods on the stroke risk post-TAVR...
April 17, 2018: Curēus
Miguel J Xavier, Lisa A Mitchell, Kristen E McEwan, Rodney Scott, Robert John Aitken
The Big Blue® λSelect-cII selection system has been employed along with whole-exome sequencing, to examine the susceptibility of the male germ line to mutation in two challenging situations: (i) exposure to a chemotherapeutic regime including bleomycin, etoposide and cis-platinum (BEP) and (ii) the ageing process. A 3-week exposure to BEP induced complete azoospermia associated with a loss of developing germ cells and extensive vacuolization of Sertoli cell cytoplasm. Following cessation of treatment, spermatozoa first appeared in the caput epididymis after 6 weeks and by 12 weeks motile spermatozoa could be recovered from the cauda, although the count (P < 0...
June 19, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Deborah Saraggi, Roberto Salmaso, Carolina Zamuner, Giada Munari, Cristiano Lanza, Mauro Salvatore Alaibac, Franco Bassetto, Massimo Rugge, Maria Cristina Montesco, Lorenzo Cerroni, Matteo Fassan
BACKGROUND: ALK gene rearrangements have been described in spitzoid lesions with plexiform growth pattern. OBJECTIVE: To investigate the prevalence of ALK alterations in a large series of spitzoid lesions. METHODS: ALK immunohistochemical and FISH analyses on 78 spitzoid plexiform lesions: 41 Spitz nevi (SN), 29 atypical Spitz tumors (ASTs), and 8 spitzoid melanomas (SMs). RESULTS: ALK immunohistochemical staining was observed in 14...
June 16, 2018: Journal of the American Academy of Dermatology
Ruggero Andrisano-Ruggieri, Pietro Crescenzo, Mario Capunzo, Francesco De Caro, Riccardo Savastano, Manuela Pennisi, Giovanni Boccia
OBJECTIVES: According to Legislative Decree n. 81/08 and Ministerial Circular of 18/11/2010, this paper proposes to verify the relationship between the sources of risk of stress, sentinel events and gender. METHODS: Sentinel events and their variations are mapped for three years. Successively, a self-reported OPRA (Organizational and Psychosocial Risk Assessment) questionnaire was administered. The sample was not probabilistic and balanced for two categories: Inside Sentinel Event and Outside Sentinel Event...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Liulu Zhang, Yijie Huang, Ciqiu Yang, Teng Zhu, Yufeng Lin, Hongfei Gao, Mei Yang, Minyi Cheng, Kun Wang
BACKGROUND: To stage axillary lymph nodes in women with early-stage breast cancer, sentinel lymph node biopsy (SLNB), rather than axillary lymph node dissection (ALND), has been employed. Moreover, different tracer methods have various advantages and disadvantages. In recent years, carbon nanoparticle suspensions (CNSs) have been used as lymph node tracers during surgeries for thyroid cancer, gastric cancer, and colorectal cancer. The study retrospectively analyzed the feasibility and accuracy of CNS for sentinel lymph node (SLN) mapping in patients with early breast cancer...
June 19, 2018: World Journal of Surgical Oncology
F Frappart, S Biancamaria, C Normandin, F Blarel, L Bourrel, M Aumont, P Azemar, P-L Vu, T Le Toan, B Lubac, J Darrozes
Lakes and reservoirs have been identified as sentinels of climate change. Tonle Sap is the largest lake in both the Mekong Basin and Southeast Asia and because of the importance of its ecosystem, it is has been described as the "heart of the lower Mekong". Its seasonal cycle depends on the annual flood pulse governed by the flow of the Mekong River. This study provides an impact analysis of recent climatic events from El Niño 1997/1998 to El Niño 2015/2016 on surface storage variations in the Tonle Sap watershed determined by combining remotely sensed observations, multispectral images and radar altimetry from 1993 to 2017...
September 15, 2018: Science of the Total Environment
Matthew G Crowson, Hillary Mulder, Derek D Cyr, Alan W Langman, Walter T Lee, Kourosh Parham, Melissa A Pynnonen, Kristine Schulz, Jennifer J Shin, David Witsell, Andrea Vambutas
OBJECTIVE: Given ongoing debate about the suggested association, the primary objective was to determine if idiopathic sudden sensorineural hearing loss (ISSNHL) was a sentinel event for acute myocardial infarction (AMI) in adults. STUDY DESIGN: Case-control study. SETTING: United States MarketScan administrative health claims database. PATIENTS: Aged 18 years or older, had a diagnosis of ISSNHL on or after January 1st, 2011 and had sufficient follow-up data available to assess for AMI occurrence...
June 15, 2018: Otology & Neurotology
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