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https://www.readbyqxmd.com/read/28822397/outcomes-after-mastectomy-and-lumpectomy-in-octogenarians-and-nonagenarians-with-early-stage-breast-cancer
#1
Amelia Y Merrill, Doris R Brown, Heidi D Klepin, Edward A Levine, Marissa Howard-Mcnatt
Prospective studies have shown equal outcomes after mastectomy or breast conservation in patients with invasive breast cancer; however, many of these studies excluded elderly patients. We identified patients in their eighties and nineties with clinical stage 0 to II breast cancer undergoing mastectomy or lumpectomy with or without radiation from the prospective sentinel lymph node database at Wake Forest Baptist Health and analyzed their treatment and survival. Of 92 patients, 24 (26.1%) underwent mastectomy, 22 (23...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28821230/seroprevalence-of-herpes-simplex-virus-type-2-hsv-2-among-pregnant-women-who-participated-in-a-national-hiv-surveillance-activity-in-haiti
#2
Jean Wysler Domercant, Frantz Jean Louis, Erin Hulland, Mark Griswold, Jocelyne Andre-Alboth, Tun Ye, Barbara J Marston
BACKGROUND: Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant women in Haiti and HSV-2 test performance in this population. METHODS: Unlinked residual serum specimens from the 2012 National HIV and Syphilis Sentinel Surveillance Survey among pregnant women in Haiti were tested using two commercial kits (Focus HerpeSelect, Kalon) for HSV-2 antibodies...
August 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28819936/introducing-navigation-during-melanoma-related-sentinel-lymph-node-procedures-in-the-head-and-neck-region
#3
Gijs H KleinJan, Baris Karakullukçu, W Martin C Klop, Thijs Engelen, Nynke S van den Berg, Fijs W B van Leeuwen
BACKGROUND: Intraoperative sentinel node (SN) identification in patients with head-and-neck malignancies can be challenging due to unexpected drainage patterns and anatomical complexity. Here, intraoperative navigation-based guidance technologies may provide outcome. In this study, gamma camera-based freehandSPECT was evaluated in combination with the hybrid tracer ICG-(99m)Tc-nanocolloid. MATERIALS AND METHODS: Eight patients with melanoma located in the head-and-neck area were included...
August 17, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28818856/deletion-of-nf-%C3%AE%C2%BAb-rela-in-angiotensin-ii-sensitive-mesenchymal-cells-blocks-aortic-vascular-inflammation-and-abdominal-aortic-aneurysm-formation
#4
Talha Ijaz, Hong Sun, Irina V Pinchuk, Dianna M Milewicz, Ronald G Tilton, Allan R Brasier
OBJECTIVE: Infusion of angiotensin II (Ang II) induces extracellular matrix remodeling and inflammation resulting in abdominal aortic aneurysms (AAAs) in normolipidemic mice. Although Ang II activates mesenchymal cells in the media and adventitia to become fibrogenic, the sentinel role of this mesenchymal population in modulating the inflammatory response and aneurysms is not known. We test the hypothesis that these fibrogenic mesenchymal cells play a critical role in Ang II-induced aortic wall vascular inflammation and AAA formation...
August 17, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28818814/exposure-to-polybrominated-diphenyl-ethers-and-perfluoroalkyl-substances-in-a-remote-population-of-alaska-natives
#5
Samuel Byrne, Samarys Seguinot-Medina, Pamela Miller, Vi Waghiyi, Frank A von Hippel, C Loren Buck, David O Carpenter
BACKGROUND: Many Alaska Native communities rely on a traditional marine diet that contains persistent organic pollutants (POPs). The indoor environment is also a source of POPs. Polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl substances (PFASs) are present both in the traditional diet and the home indoor environment. OBJECTIVES: We assessed exposure to PBDEs and PFASs among residents of two remote Alaska Native villages on St. Lawrence Island. Ninespine stickleback (Pungitious pungitious) and Alaska blackfish (Dallia pectoralis) were used to detect accumulation of these compounds in the local environment...
August 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28818544/trends-in-antimicrobial-resistance-in-bloodstream-infection-isolates-at-a-large-urban-hospital-in-malawi-1998-2016-a-surveillance-study
#6
Patrick Musicha, Jennifer E Cornick, Naor Bar-Zeev, Neil French, Clemens Masesa, Brigitte Denis, Neil Kennedy, Jane Mallewa, Melita A Gordon, Chisomo L Msefula, Robert S Heyderman, Dean B Everett, Nicholas A Feasey
BACKGROUND: Bacterial bloodstream infection is a common cause of morbidity and mortality in sub-Saharan Africa, yet few facilities are able to maintain long-term surveillance. The Malawi-Liverpool-Wellcome Trust Clinical Research Programme has done sentinel surveillance of bacteraemia since 1998. We report long-term trends in bloodstream infection and antimicrobial resistance from this surveillance. METHODS: In this surveillance study, we analysed blood cultures that were routinely taken from adult and paediatric patients with fever or suspicion of sepsis admitted to Queen Elizabeth Central Hospital, Blantyre, Malawi from 1998 to 2016...
August 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28818521/current-approach-of-the-axilla-in-patients-with-early-stage-breast-cancer
#7
REVIEW
Eleftherios P Mamounas, Thorsten Kuehn, Emiel J T Rutgers, Gunter von Minckwitz
The surgical approach of the axilla in patients with early-stage breast cancer has witnessed considerable evolution during the past 25 years. The previously undisputed gold standard of axillary-lymph-node dissection for staging has now been replaced by sentinel-lymph-node biopsy for patients with clinically negative axilla. For selected patients with limited sentinel-lymph-node involvement, completion axillary-lymph-node dissection can be omitted or replaced by axillary radiotherapy, reducing morbidity. The clinical interest of axillary staging after neoadjuvant chemotherapy is increasing and this approach might contribute to morbidity reduction, and to the further tailoring of future systemic and locoregional treatment decisions by response assessment...
August 14, 2017: Lancet
https://www.readbyqxmd.com/read/28818349/fifteen-year-decrease-in-general-surgery-resident-breast-operative-experience-are-we-training-proficient-breast-surgeons
#8
Kelsey E Larson, Stephen R Grobmyer, Mika A B Reschke, Stephanie A Valente
OBJECTIVE: The goal of the study was to evaluate trends in general surgery resident breast cases over the past 15 years. STUDY DESIGN: The Accreditation Council for Graduate Medical Education (ACGME) Case Logs Statistics Reports from 2000 to 2015 were reviewed for average breast-specific case numbers and trends over time. ACGME data were available for all cases and breast-specific cases including the following: excisional biopsy/lumpectomy, simple mastectomy, modified radical mastectomy, and sentinel lymph node excision...
August 14, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28818085/a-rare-case-of-acute-toxoplasmosis-in-a-stray-dog-due-to-infection-of-t-gondii-clonal-type-i-public-health-concern-in-urban-settings-with-stray-animals
#9
Sergio Migliore, Salvatore La Marca, Cristian Stabile, Vincenzo Di Marco Lo Presti, Maria Vitale
BACKGROUND: Typing of Toxoplasma gondii strains is important in epidemiological surveys, to understand the distribution and virulence of different clones of the parasite among human and animal populations. Stray dogs can be consider sentinel animals for contaminated environments playing an important but probably under- evaluated role in the epidemiology of T. gondii. We reported a rare case of acute toxoplasmosis in a stray dog due to clonal type I infection. The clonal type I, sporadic in Europe, is frequently associated with severe toxoplasmosis in humans and the control of its circulation is particularly relevant for public health...
August 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28818077/evaluation-of-piperonyl-butoxide-in-enhancing-the-efficacy-of-pyrethroid-insecticides-against-resistant-anopheles-gambiae-s-l-in-ghana
#10
Samuel K Dadzie, Joseph Chabi, Andy Asafu-Adjaye, Otubea Owusu-Akrofi, Aba Baffoe-Wilmot, Keziah Malm, Constance Bart-Plange, Sylvester Coleman, Maxwell A Appawu, Daniel A Boakye
BACKGROUND: Malaria vector control methods involving the use of pyrethroids remain the strategies being used against malaria vectors in Ghana. These methods include the use of long-lasting insecticidal nets and indoor residual spraying in many areas in Ghana. However, there is evidence that pyrethroid resistance is widespread in many areas in Ghana. Synergists have been shown to be useful in inhibiting the enzymes that are responsible for the development of resistance and hence enhance the insecticide susceptibility of Anopheles gambiae sensu lato (s...
August 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28816649/improving-regional-influenza-surveillance-through-a-combination-of-automated-outbreak-detection-methods-the-2015-16-season-in-france
#11
Camille Pelat, Isabelle Bonmarin, Marc Ruello, Anne Fouillet, Céline Caserio-Schönemann, Daniel Levy-Bruhl, Yann Le Strat
The 2014/15 influenza epidemic caused a work overload for healthcare facilities in France. The French national public health agency announced the start of the epidemic - based on indicators aggregated at the national level - too late for many hospitals to prepare. It was therefore decided to improve the influenza alert procedure through (i) the introduction of a pre-epidemic alert level to better anticipate future outbreaks, (ii) the regionalisation of surveillance so that healthcare structures can be informed of the arrival of epidemics in their region, (iii) the standardised use of data sources and statistical methods across regions...
August 10, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28815981/positive-messages-for-bladder-cancer-management-in-negative-sentinel-lymph-node-study
#12
EDITORIAL
Tim Dudderidge
No abstract text is available yet for this article.
September 2017: BJU International
https://www.readbyqxmd.com/read/28815480/evaluation-of-electronic-healthcare-databases-for-post-marketing-drug-safety-surveillance-and-pharmacoepidemiology-in-china
#13
Yu Yang, Xiaofeng Zhou, Shuangqing Gao, Hongbo Lin, Yanming Xie, Yuji Feng, Kui Huang, Siyan Zhan
INTRODUCTION: Electronic healthcare databases (EHDs) are used increasingly for post-marketing drug safety surveillance and pharmacoepidemiology in Europe and North America. However, few studies have examined the potential of these data sources in China. METHODS: Three major types of EHDs in China (i.e., a regional community-based database, a national claims database, and an electronic medical records [EMR] database) were selected for evaluation. Forty core variables were derived based on the US Mini-Sentinel (MS) Common Data Model (CDM) as well as the data features in China that would be desirable to support drug safety surveillance...
August 16, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28814071/feasibility-of-charcoal-tattooing-of-cytology-proven-metastatic-axillary-lymph-node-at-diagnosis-and-sentinel-lymph-node-biopsy-after-neoadjuvant-chemotherapy-in-breast-cancer-patients
#14
Seho Park, Ja Seung Koo, Gun Min Kim, Joohyuk Sohn, Seung Il Kim, Young Up Cho, Byeong-Woo Park, Vivian Youngjean Park, Jung Hyun Yoon, Hee Jung Moon, Min Jung Kim, Eun-Kyung Kim
Purpose: Sentinel lymph node biopsy (SLNB) can be performed when node-positive disease is converted to node-negative status after neoadjuvant chemotherapy (NCT). Tattooing nodes might improve accuracy but supportive data are limited. This study aimed to investigate the feasibility of charcoal tattooing metastatic axillary lymph node (ALN) at presentation followed by SLNB after NCT in breast cancers. Materials and Methods: Twenty patients with cytology-proven node metastases prospectively underwent charcoal tattooing at diagnosis...
August 17, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28812957/examining-gender-bias-in-the-feedback-shared-with-family-medicine-residents
#15
Chantal Loeppky, Oksana Babenko, Shelley Ross
OBJECTIVES: Competency-based education places increasing emphasis on formative feedback to learners as part of the assessment process. We wished to determine if gender bias was present in the feedback shared with post-graduate medical trainees (residents) in a two-year family medicine residency program at a Canadian university. METHODS: We performed secondary data analyses of documented feedback (FieldNotes) extracted from the Competency-Based Achievement System database...
August 16, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28812547/lung-epithelial-cells-therapeutically-inducible-effectors-of-antimicrobial-defense
#16
REVIEW
M M Leiva-Juárez, J K Kolls, S E Evans
Lung epithelial cells are increasingly recognized to be active effectors of microbial defense, contributing to both innate and adaptive immune function in the lower respiratory tract. As immune sentinels, lung epithelial cells detect diverse pathogens through an ample repertoire of membrane-bound, endosomal, and cytosolic pattern-recognition receptors (PRRs). The highly plastic epithelial barrier responds to detected threats via modulation of paracellular flux, intercellular communications, mucin production, and periciliary fluid composition...
August 16, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28810870/vector-borne-and-zoonotic-diseases-of-dogs-in-north-west-new-south-wales-and-the-northern-territory-australia
#17
Amanda J Shapiro, Graeme Brown, Jacqueline M Norris, Katrina L Bosward, Debbie J Marriot, Nandhakumar Balakrishnan, Edward B Breitschwerdt, Richard Malik
BACKGROUND: Vector-borne diseases of dogs in Australian Aboriginal communities are relatively unexplored. These dogs represent a unique group with variable ecto- and endo-parasitic burdens, nutritional stresses and a general lack of veterinary intervention. We investigated haemoprotozoal and bacterial pathogen prevalences in relation to erythrocyte and platelet numbers in dogs from North-West New South Wales (N-W NSW) and the Northern Territory (NT; Central Australia). METHODS: Real-time PCR (qPCR) amplification of Anaplasma platys, Babesia vogeli, Mycoplasma haemocanis, Candidatus Mycoplasma haematoparvum and Bartonella spp...
August 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28808943/a-logistic-regression-model-predicting-high-axillary-tumour-burden-in-early-breast-cancer-patients
#18
I Barco, M García Font, A García-Fernández, N Giménez, M Fraile, J M Lain, E Vallejo, S González, L Canales, J Deu, M C Vidal, M Rodríguez-Carballeira, A Pessarrodona, C Chabrera
PURPOSE: As elective axillary dissection is loosing ground for early breast cancer (BC) patients both in terms of prognostic and therapeutic power, there is a growing interest in predicting patients with (nodal) high tumour burden (HTB), especially after a positive sentinel node biopsy (SNB) because they would really benefit from further axillary intervention either by complete lymph-node dissection or axillary radiation therapy. METHODS/PATIENTS: Based on an analysis of 1254 BC patients in whom complete axillary clearance was performed, we devised a logistic regression (LR) model to predict those with HTB, as defined by the presence of three or more involved nodes with macrometastasis...
August 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28808843/feasibility-of-preoperative-axillary-lymph-node-marking-with-a-clip-in-breast-cancer-patients-before-neoadjuvant-chemotherapy-a-preliminary-study
#19
Eun Young Kim, Woo Seok Byon, Kwan Ho Lee, Ji-Sup Yun, Yong Lai Park, Chan Heun Park, In Young Youn, Seon Hyeong Choi, Yoon Jung Choi, Shin Ho Kook, Sung-Im Do
BACKGROUND: The aim of this study was to determine the feasibility of image-guided marker-clip placement in axillary lymph nodes (ALNs) for breast cancer upon initial presentation and to assess the reliability of this method with sentinel lymph node biopsy (SLNB) for axillary restaging after neoadjuvant chemotherapy (NAC). METHODS: Between June 2015 and August 2016, a marker clip was placed at a clinically positive ALN under ultrasonography (US) guidance before initiation of NAC in 20 patients...
August 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28807805/laparoscopic-sentinel-node-mapping-in-cervical-and-endometrial-malignancies-a-case-control-study-comparing-two-near-infrared-fluorescence-systems
#20
Alessandro Buda, Giampaolo Di Martino, Elena De Ponti, Paolo Passoni, Federica Sina, Claudio Reato, Francesca Vecchione, Daniela Giuliani
STUDY OBJECTIVE: the goal of this study was to evaluate the intraoperative and perioperative surgical outcomes of two different florescence systems commonly utilized for sentinel lymph node (SLN) mapping in women with early stage cervical cancer or endometrial cancer. DESIGN: Case-control study. DESIGN CLASSIFICATION: Canadian Task-force II-2 SETTING: The study was conducted in the Gynecology Oncology Surgical Unit of the San Gerardo Hospital, Italy...
August 11, 2017: Journal of Minimally Invasive Gynecology
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