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Growth factors and sepsis

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https://www.readbyqxmd.com/read/29764503/bacteriological-profile-of-neonatal-sepsis-and-antibiotic-susceptibility-pattern-of-isolates-admitted-at-kanti-children-s-hospital-kathmandu-nepal
#1
Nikita Singh Yadav, Saroj Sharma, Dhiraj Kumar Chaudhary, Prabhat Panthi, Pankaj Pokhrel, Anil Shrestha, Pappu Kumar Mandal
OBJECTIVE: Neonatal sepsis is a major cause of morbidity and mortality of newborns (< 1 month of age). Septicemia and drug resistance is a predominant issue for neonatal death in Nepal. This study is intended to find bacteriological profile of neonatal sepsis and antibiotic susceptibility pattern of the isolates from neonates at Kanti Children's Hospital, Kathmandu, Nepal. RESULTS: Out of 350 suspected cases of neonatal sepsis, 59 (16.9%) cases showed positive blood culture...
May 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29686180/chromobacterium-violaceum-the-deadly-sepsis
#2
Guntur Darmawan, R N Yasmin Kusumawardhani, Bachti Alisjahbana, Trinugroho Heri Fadjari
Chromobacterium violaceum is a Gram-negative facultatively anaerobic, oxidase-positive bacterium producing a dark violet antioxidant pigment called violacein. It is an opportunistic pathogen and has an ubiquitous distribution, mainly resides in water and soil of tropical and subtropical regions.An-18-year-old man referred to the emergency room with a 5-day history of progressively worsening swelling of the right cheek. He sought consult and hospitalized at another institution for three days prior this admission; however, his condition deteriorated...
January 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29681903/inflammatory-mediator-profiles-differ-in-sepsis-patients-with-and-without-bacteremia
#3
Knut Anders Mosevoll, Steinar Skrede, Dagfinn Lunde Markussen, Hans Rune Fanebust, Hans Kristian Flaatten, Jörg Aßmus, Håkon Reikvam, Øystein Bruserud
Systemic levels of cytokines are altered during infection and sepsis. This prospective observational study aimed to investigate whether plasma levels of multiple inflammatory mediators differed between sepsis patients with and those without bacteremia during the initial phase of hospitalization. A total of 80 sepsis patients with proven bacterial infection and no immunosuppression were included in the study. Plasma samples were collected within 24 h of hospitalization, and Luminex® analysis was performed on 35 mediators: 16 cytokines, six growth factors, four adhesion molecules, and nine matrix metalloproteases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29666026/cervical-cancer-state-of-the-science-from-angiogenesis-blockade-to-checkpoint-inhibition
#4
REVIEW
Lindsey E Minion, Krishnansu S Tewari
Vascular endothelial growth factor (VEGF) has emerged as a therapeutic target in several malignancies, including cervical cancer. Chemotherapy doublets combined with the fully humanized monoclonal antibody, bevacizumab, now constitute first-line therapy for women struggling with recurrent/metastatic cervical carcinoma. Regulatory approval for this indication was based on the phase III randomized trial, GOG 240, which demonstrated a statistically significant and clinically meaningful improvement in overall survival when bevacizumab was added to chemotherapy: 17...
March 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29660161/the-fgf-23-klotho-axis-and-its-relationship-with-phosphorus-calcium-vitamin-d-pth-aldosterone-severity-of-disease-and-outcome-in-hospitalised-foals
#5
A M Kamr, K A Dembek, B E Hildreth, P R Morresey, R A Rathgeber, T A Burns, A A Zaghawa, R E Toribio
BACKGROUND: Fibroblast growth factor-23 (FGF-23) and klotho are key regulators of vitamin D and parathyroid hormone (PTH) synthesis as well as phosphorus and calcium homeostasis; however, information on the FGF-23/klotho axis in healthy and hospitalised foals is lacking. OBJECTIVES: The aims of this study were to measure serum FGF-23 and klotho concentrations and determine their association with serum phosphorus, total calcium (TCa), vitamin D metabolite [25(OH)D, 1,25(OH)2 D], PTH, and aldosterone concentrations, disease severity, and mortality in hospitalised foals...
April 16, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29601599/vcam-1-expression-is-upregulated-by-cd34-cd133-stem-cells-derived-from-septic-patients
#6
Christian Patry, Christoph Remmé, Christian Betzen, Burkhard Tönshoff, Benito A Yard, Grietje Beck, Neysan Rafat
CD34+/CD133+- cells are a bone marrow derived stem cell population, which presumably contain vascular progenitor cells and are associated with improved vascular repair. In this study, we investigated whether the adhesion molecules ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), E-selectin und L-selectin, which are involved in homing of vascular stem cells, are upregulated by CD34+/CD133+-stem cells from septic patients and would be associated with improved clinical outcome...
2018: PloS One
https://www.readbyqxmd.com/read/29599842/therapeutic-effects-of-simvastatin-combined-with-kallistatin-treatment-for-pediatric-burn-patients-with-sepsis
#7
Yefeng Dai, Xufei Zhao
The aim of the present study was to examine the combined efficacy of simvastatin and kallistatin treatment for pediatric burn sepsis. A total of 72 pediatric patients with burn sepsis were recruited and randomly divided into 3 groups, receiving simvastatin (40 mg/day), kallistatin (20 mg/day) or combined treatment. ELISA, reverse transcription-quantitative polymerase chain reaction, western blotting and flow cytometry were used to analyze the therapeutic effects of simvastatin and kallistatin. The results revealed that combined treatment in pediatric burn sepsis patients decreased the inflammatory cytokine tumor necrosis factor α and interleukin (IL)-1β serum levels, whereas it increased IL-10 and human leukocyte antigen-D related levels...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29566694/4-acetylantroquinonol-b-inhibits-lipopolysaccharide-induced-cytokine-release-and-alleviates-sepsis-through-of-mapk-and-nf%C3%AE%C2%BAb-suppression
#8
Chien-Hsin Chang, Chun-Chieh Hsu, An-Sheng Lee, Shih-Wei Wang, Kung-Tin Lin, Wei-Luen Chang, Hui-Chin Peng, Wen-Chiung Huang, Ching-Hu Chung
BACKGROUND: Antrodia cinnamomea is an indigenous medicinal mushroom in Taiwan, commonly used for the treatment of cancers and inflammatory disorders. 4-acetylantroquinonol B (4AAQB) is one of the active component isolated from the mycelium of A. cinnamomea. However, whether 4AAQB exhibits anti-inflammatory effect is not clear. METHODS: The anti-inflammatory activity of 4AAQB was examined by ELISA to measure the pro-inflammatory cytokines production in lipopolysaccharide (LPS)-simulated RAW264...
March 23, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29523274/an-sflt-1-plgf-ratio-of-655-is-not-a-reliable-cut-off-value-for-predicting-perinatal-outcomes-in-women-with-preeclampsia
#9
Myriam Stolz, Harald Zeisler, Florian Heinzl, Julia Binder, Alex Farr
OBJECTIVES: The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is increased in preeclampsia. This study evaluated perinatal outcomes in cases with an sFlt-1:PlGF ratio above 655. STUDY DESIGN: We retrospectively analyzed data from all consecutive women with singleton pregnancies who presented with clinically manifest preeclampsia and underwent immediate sFlt-1:PlGF assessment. Cases with an sFlt-1:PlGF ratio ≥ 655 were matched 1:1 for gestational age to controls with a ratio < 655...
January 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29491858/characterization-of-asymptomatic-bacteriuria-escherichia-coli-isolates-in-search-of-alternative-strains-for-efficient-bacterial-interference-against-uropathogens
#10
Christoph Stork, Beáta Kovács, Barnabás Rózsai, Johannes Putze, Matthias Kiel, Ágnes Dorn, Judit Kovács, Szilvia Melegh, Andreas Leimbach, Tamás Kovács, György Schneider, Monika Kerényi, Levente Emödy, Ulrich Dobrindt
Asymptomatic bacterial colonization of the urinary bladder (asymptomatic bacteriuria, ABU) can prevent bladder colonization by uropathogens and thus symptomatic urinary tract infection (UTI). Deliberate bladder colonization with Escherichia coli ABU isolate 83972 has been shown to outcompete uropathogens and prevent symptomatic UTI by bacterial interference. Many ABU isolates evolved from uropathogenic ancestors and, although attenuated, may still be able to express virulence-associated factors. Our aim was to screen for efficient and safe candidate strains that could be used as alternatives to E...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29471109/extensively-drug-resistant-acinetobacter-baumannii-bacteremias-in-a-multidisciplinary-intensive-care-unit-during-a-6-year-period-risk-factors-for-fulminant-sepsis
#11
M Katsiari, A Mavroidi, E D Platsouka, C Nikolaou
OBJECTIVES: The aim of the present study was to determine potential host-, pathogen-, infection- and treatment-related risk factors that might predict a fulminant, fatal course of bacteremia caused extensively drug-resistant A. baumannii (XDR Aba). METHODS: Eighty-seven patients with monomicrobial growth of XDR Aba in blood cultures within a 6-year period were studied. Patients were divided into three groups, according to ICU outcome. Group A (n=40) consisted of patients who survived, Group B (n=10) included patients with fulminant sepsis that died early (<48h), whereas Group C (n=37) included patients that died later (> 48h) after the onset of bacteremia...
February 19, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29415278/protease-activated-receptor-2-facilitates-bacterial-dissemination-in-pneumococcal-pneumonia
#12
Florry E van den Boogaard, Xanthe Brands, JanWillem Duitman, Sacha F de Stoppelaar, Keren S Borensztajn, Joris J T H Roelofs, Morley D Hollenberg, C Arnold Spek, Marcus J Schultz, Cornelis van 't Veer, Tom van der Poll
Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. Protease-activated receptor 2 (PAR2) is expressed by different cell types in the lungs and can mediate inflammatory responses. We sought to determine the role of PAR2 during pneumococcal pneumonia. Pneumococcal pneumonia or sepsis was induced in wild-type and PAR2 knock-out (Par2-/-) mice by infection with viable S. pneumoniae. Par2-/- mice demonstrated improved host defense, a largely preserved lung barrier integrity, and reduced mortality during pneumococcal pneumonia...
April 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29395333/erythropoietin-induces-bone-marrow-and-plasma-fibroblast-growth-factor-23-during-acute-kidney-injury
#13
Luis Toro, Víctor Barrientos, Pablo León, Macarena Rojas, Magdalena Gonzalez, Alvaro González-Ibáñez, Sebastián Illanes, Keigo Sugikawa, Néstor Abarzúa, César Bascuñán, Katherine Arcos, Carlos Fuentealba, Ana María Tong, Alvaro A Elorza, María Eugenia Pinto, Rodrigo Alzamora, Carlos Romero, Luis Michea
It is accepted that osteoblasts/osteocytes are the major source for circulating fibroblast growth factor 23 (FGF23). However, erythropoietic cells of bone marrow also express FGF23. The modulation of FGF23 expression in bone marrow and potential contribution to circulating FGF23 has not been well studied. Moreover, recent studies show that plasma FGF23 may increase early during acute kidney injury (AKI). Erythropoietin, a kidney-derived hormone that targets erythropoietic cells, increases in AKI. Here we tested whether an acute increase of plasma erythropoietin induces FGF23 expression in erythropoietic cells of bone marrow thereby contributing to the increase of circulating FGF23 in AKI...
May 2018: Kidney International
https://www.readbyqxmd.com/read/29391357/prostatic-abscess-a-rare-complication-of-staghorn-calculi
#14
Mohammed Kamil Quraishi, Yih Chyn Phan, Wael Asaad, Naing Lynn
A staghorn calculus is a calculus accommodating the majority of a renal calyx extending into the renal pelvis. A conservative approach to its treatment may lead to high morbidity and mortality rates. Such morbidity usually manifests with renal failure, obstructed upper urinary tractand/or life-threatening sepsis. Prostatic abscesses have never been associated with staghorn calculi in the literature. We report a case of a 70-year-old man who presented with sepsis, which was found to originate from a complex prostatic abscess...
February 1, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29363724/effect-of-bone-marrow-mesenchymal-stem-cells-on-the-polarization-of-macrophages
#15
Yuan Hua Zheng, Yi Yu Deng, Wen Lai, Shao Yi Zheng, Hui Ning Bian, Zu An Liu, Zhi Feng Huang, Chuan Wei Sun, Han Hua Li, Hong Min Luo, Liang Hua Ma, Han Xi Chen, Bing Xiong
Inflammation is a defensive response in the living tissue of the vascular system that acts against damage factors and involves various types of immune cells, including macrophages, neutrophils, endothelial cells and other associated immune molecules. If the release of inflammatory mediators is excessive, systemic inflammatory response syndrome may develop. Sepsis is the most common complication of severe burns and is a systemic inflammatory response syndrome that is caused by infectious factors and is capable of leading to multiple organ dysfunction and potentially death...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29324627/effects-of-the-humanized-anti-adrenomedullin-antibody-adrecizumab-ham8101-on-vascular-barrier-function-and-survival-in-rodent-models-of-systemic-inflammation-and-sepsis
#16
Christopher Geven, Esther Peters, Mathias Schroedter, Joachim Struck, Andreas Bergmann, Oscar McCook, Peter Radermacher, Matthijs Kox, Peter Pickkers
PURPOSE: Adrenomedullin (ADM) is an important regulator of endothelial barrier function during sepsis. Administration of a murine antibody targeted against the N-terminus of ADM (HAM1101) resulted in improved outcome in models of murine sepsis. We studied the effects of a humanized form of this antibody (HAM8101, also known as Adrecizumab) on vascular barrier dysfunction and survival in rodent models of systemic inflammation and sepsis. METHODS: Rats (n=48) received different dosages of HAM8101 or placebo (n = 8 per group), directly followed by administration of lipopolysaccharide (5 mg/kg)...
January 10, 2018: Shock
https://www.readbyqxmd.com/read/29300996/factors-associated-with-time-to-full-feeds-in-preterm-very-low-birth-weight-infants
#17
Gaurav Patwardhan, Ankit Soni, Nitin Rachwani, Sandeep Kadam, Sanjay Patole, Anand Pandit
Background: Feeding intolerance prolongs time to full feeds (TFFs) in preterm infants. We studied factors associated with TFF in preterm infants on standardized feeding regimen (SFR) and routine probiotic supplementation (RPS). Methods: This is a prospective cohort study of preterm infants ≤1500 g. Pearson's correlation, Mann-Whitney test and multivariate analysis were used. Results: In total, 37 of 304 admitted infants died before reaching full feeds...
December 28, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29245072/phloretin-attenuates-mucus-hypersecretion-and-airway-inflammation-induced-by-cigarette-smoke
#18
Hao Wang, Ting Yang, Tao Wang, Nanya Hao, Yongchun Shen, Yanqiu Wu, Zhicheng Yuan, Lei Chen, Fuqiang Wen
BACKGROUNDS: Cigarette smoke (CS)-induced airway mucus hypersecretion and inflammation are the prominent features of chronic obstructive pulmonary disease (COPD). As an anti-inflammatory flavonoid, phloretin was found to be involved in various inflammatory disorders such as sepsis. In this study, the effects of phloretin on CS-induced airway mucin secretion and inflammation were investigated in vivo and in vitro. METHODS: Phloretin dissolved in 1% DMSO was daily injected intraperitoneally to mice, which were then exposed to CS for four weeks...
February 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29208882/thrombocytopenia-in-late-onset-neonatal-sepsis-and-its-relationship-with-specific-organism-in-a-tertiary-care-hospital
#19
F Ahmed, A Y Raj, L N Begum
Late onset neonatal sepsis (LONS) is a common complication in the Neonatal Intensive Care Unit (NICU) especially in premature infants, in whom the clinical presentation can be subtle and nonspecific. Thrombocytopenia is an important complication of sepsis. The objective of the present study was to identify the organism-speci?c platelet response in neonate with culture proven LONS. In this retrospective study all the infants with blood culture positive LONS in the neonatal intensive care unit (NICU) at Square Hospitals Ltd...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29203193/fructose-1-6-bisphosphatase-deficiency-as-a-cause-of-recurrent-hypoglycemia-and-metabolic-acidosis-clinical-and-molecular-findings-in-malaysian-patients
#20
Lip Hen Moey, Nor Azimah Abdul Azize, Yusnita Yakob, Huey Yin Leong, Wee Teik Keng, Bee Chin Chen, Lock Hock Ngu
BACKGROUND: Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare autosomal recessive inborn error of gluconeogenesis. We reported the clinical findings and molecular genetic data in seven Malaysian patients with FBPase deficiency. METHODS: All patients diagnosed with FBPase deficiency from 2010 to 2015 were included in this study. Their clinical and laboratory data were collected retrospectively. RESULTS: All the patients presented with recurrent episodes of hypoglycemia, metabolic acidosis, hyperlactacidemia and hepatomegaly...
November 13, 2017: Pediatrics and Neonatology
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