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Breast Cancer, Breast Reconstruction

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https://www.readbyqxmd.com/read/27911904/dressing-wear-time-after-breast-reconstruction-a-randomized-clinical-trial
#1
Daniela Francescato Veiga, Carlos Américo Veiga Damasceno, Joel Veiga-Filho, Luiz Francisley Paiva, Fernando Elias Martins Fonseca, Isaías Vieira Cabral, Natália Lana Larcher Pinto, Yara Juliano, Lydia Masako Ferreira
BACKGROUND: The evidence to support dressing standards for breast surgery wounds is empiric and scarce. OBJECTIVE: This two-arm randomized clinical trial was designed to assess the effect of dressing wear time on surgical site infection (SSI) rates, skin colonization and patient perceptions. METHODS: A total of 200 breast cancer patients undergoing breast reconstruction were prospectively enrolled. Patients were randomly allocated to group I (dressing removed on the first postoperative day, n = 100) or group II (dressing removed on the sixth postoperative day, n = 100)...
2016: PloS One
https://www.readbyqxmd.com/read/27906762/complications-in-postmastectomy-breast-reconstruction-one-year-outcomes-of-the-mastectomy-reconstruction-outcomes-consortium-mroc-study
#2
Edwin G Wilkins, Jennifer B Hamill, Hyungjin M Kim, John Y Kim, Richard J Greco, Ji Qi, Andrea L Pusic
OBJECTIVE: In postmastectomy reconstruction, procedure choice is heavily influenced by the relative risks of the various options. This study sought to evaluate complications in a large, multicenter patient population. SUMMARY OF BACKGROUND DATA: Previous studies have reported widely varying complication rates, but have been limited by their single center designs and inadequate controlling for confounders in their analyses. METHODS: Eleven sites enrolled women undergoing first time, immediate, or delayed reconstruction following mastectomy for cancer treatment or prophylaxis...
November 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27901048/sparsity-based-multi-height-phase-recovery-in-holographic-microscopy
#3
Yair Rivenson, Yichen Wu, Hongda Wang, Yibo Zhang, Alborz Feizi, Aydogan Ozcan
High-resolution imaging of densely connected samples such as pathology slides using digital in-line holographic microscopy requires the acquisition of several holograms, e.g., at >6-8 different sample-to-sensor distances, to achieve robust phase recovery and coherent imaging of specimen. Reducing the number of these holographic measurements would normally result in reconstruction artifacts and loss of image quality, which would be detrimental especially for biomedical and diagnostics-related applications...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27898602/novel-high-spatiotemporal-resolution-versus-standard-of-care-dynamic-contrast-enhanced-breast-mri-comparison-of-image-quality
#4
Courtney K Morrison, Leah C Henze Bancroft, Wendy B DeMartini, James H Holmes, Kang Wang, Ryan J Bosca, Frank R Korosec, Roberta M Strigel
OBJECTIVE: Currently, dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI) prioritizes spatial resolution over temporal resolution given the limitations of acquisition techniques. The purpose of our intrapatient study was to assess the ability of a novel high spatial and high temporal resolution DCE breast MRI method to maintain image quality compared with the clinical standard-of-care (SOC) MRI. MATERIALS AND METHODS: Thirty patients, each demonstrating a focal area of enhancement (29 benign, 1 cancer) on their SOC MRI, consented to undergo a research DCE breast MRI on a second date...
November 28, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27895339/breast-reconstruction-at-the-aga-khan-university-a-10-year-audit
#5
Samiullah Abdullah, Asif Ahsan, Tahir Shafi Khan
Considering the high incidence of breast cancer and the subsequent need for a mastectomy, the number of patients having breast reconstruction remains relatively low the world over. Most studies from the west show that anywhere between 5% to around 50% of women proceed to reconstruction following a complete mastectomy. There is a great paucity of literature on the subject in Pakistan. Anecdotal and unofficial accounts would suggest that less than a fraction of 1% of women in Pakistan undergo reconstruction following a mastectomy...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27893626/molecular-profiling-using-breast-cancer-subtype-to-plan-for-breast-reconstruction
#6
Lars Johan Sandberg, Mark W Clemens, W F Symmans, Vicente Valero, Abigail S Caudle, Benjamin Smith, Henry M Kuerer, Limin Hsu, Steven J Kronowitz
BACKGROUND: Molecular profiling using breast cancer subtype has an increasing role in the multidisciplinary care of the breast cancer patient. We sought to determine the role of breast cancer subtyping in breast reconstruction and specifically if breast cancer subtyping can determine the need for postmastectomy radiation therapy (PMRT) and predict recurrence-free survival (RFS) to plan for the timing and technique of breast reconstruction. METHODS: We reviewed prospectively collected data from 1931 reconstructed breasts in breast cancer patients who underwent mastectomy between November 1999 and December 2012...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27890331/the-safety-of-same-day-breast-reconstructive-surgery-an-analysis-of-short-term-outcomes
#7
Erin Cordeiro, Toni Zhong, Timothy Jackson, Tulin Cil
BACKGROUND: We sought to examine the safety of same-day breast reconstructive (BR) surgery. METHODS: An analysis of the American College of Surgeons, National Surgical Quality Improvement Program (ACS-NSQIP) files was performed. Patients undergoing BR for breast cancer were examined, excluding those with high-risk co-morbidities or concurrent surgery. A propensity score was calculated and a multivariable logistic regression analysis was used to calculate the difference in 30-day complications between those undergoing SDS versus longer hospital stay...
November 12, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27888350/totally-implantable-vascular-access-device-tivad-placement-a-modified-technique-that-takes-post-procedure-aesthetic-aspects-into-account
#8
Gabriel Liberale
Major progress has been made in breast cancer reconstruction surgery. The standard technique for totally implanted vascular access device (TIVAD) implantation generally requires an incision for port insertion on the anterior part of the thorax that leaves a scar in the middle of the neckline in patients who have undergone mastectomy with complex breast reconstruction. The aim of this technical note is to report our revised surgical technique for TIVAD placement. In patients with breast cancer, we take a lateralized approach, performing an oblique incision on the lowest part of the deltopectoral groove...
November 25, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27887867/evaluation-of-function-and-recovery-of-adipose-derived-stem-cells-after-exposure-to-paclitaxel
#9
William M Harris, Ping Zhang, Michael Plastini, Telisha Ortiz, Nikolas Kappy, Jefferson Benites, Edward Alexeev, Shaohua Chang, Ross Brockunier, Jeffrey P Carpenter, Spencer A Brown
BACKGROUND AIMS: Adipose-derived stem cells (ASCs) are considered to play a positive role in wound healing as evidenced by their increasing use in breast reconstructive procedures. After chemotherapy for breast cancer, poor soft tissue wound healing is a major problem. In the present study, the functional capabilities and recovery of ASCs after exposure to chemotherapeutic agent paclitaxel (PTX) using in vitro and ex vivo models were demonstrated. METHODS: Human ASCs were isolated from periumbilical fat tissue and treated with PTX at various concentrations...
November 22, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27885679/clinical-auditing-as-an-instrument-for-quality-improvement-in-breast-cancer-care-in-the-netherlands-the-national-nabon-breast-cancer-audit
#10
Annelotte C M van Bommel, Pauline E R Spronk, Marie-Jeanne T F D Vrancken Peeters, Agnes Jager, Marc Lobbes, John H Maduro, Marc A M Mureau, Kay Schreuder, Carolien H Smorenburg, Janneke Verloop, Pieter J Westenend, Michel W J M Wouters, Sabine Siesling, Vivianne C G Tjan-Heijnen, Thijs van Dalen
BACKGROUND: In 2011, the NABON Breast Cancer Audit (NBCA) was instituted as a nation-wide audit to address quality of breast cancer care and guideline adherence in the Netherlands. The development of the NBCA and the results of 4 years of auditing are described. METHODS: Clinical and pathological characteristics of patients diagnosed with invasive breast cancer or in situ carcinoma (DCIS) and information regarding diagnosis and treatment are collected in all hospitals (n = 92) in the Netherlands...
November 25, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27885675/intratissue-lymphovenous-communications-in-the-mechanism-of-action-of-vascularized-lymph-node-transfer
#11
María Miranda Garcés, Gemma Pons, Rosa Mirapeix, Jaume Masià
BACKGROUND AND OBJECTIVES: Vascularized lymph node transfer (VLNT) as a surgical treatment for cancer-related lymphedema has shown beneficial effects. The mechanism of action of this procedure involves lymphangiogenesis and lymphovenous communications (LVC) within the lymph nodes. We propose intratissue LVC as an additional element responsible for drainage of lymph to blood in the flap and examine this hypothesis in the current study. METHODS: This prospective study determined the passage of lymph to the venous system via intratissue LVC in 26 free flaps used for breast reconstruction...
November 25, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27876826/bgrmi-a-method-for-inferring-gene-regulatory-networks-from-time-course-gene-expression-data-and-its-application-in-breast-cancer-research
#12
Luis F Iglesias-Martinez, Walter Kolch, Tapesh Santra
Reconstructing gene regulatory networks (GRNs) from gene expression data is a challenging problem. Existing GRN reconstruction algorithms can be broadly divided into model-free and model-based methods. Typically, model-free methods have high accuracy but are computation intensive whereas model-based methods are fast but less accurate. We propose Bayesian Gene Regulation Model Inference (BGRMI), a model-based method for inferring GRNs from time-course gene expression data. BGRMI uses a Bayesian framework to calculate the probability of different models of GRNs and a heuristic search strategy to scan the model space efficiently...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876309/vertical-breast-measurement-in-east-asian-women-a-guide-for-mastopexy-and-reduction-to-form-nonptotic-breasts-in-unilateral-prosthetic-breast-reconstruction
#13
Takashi Fujiwara, Kenji Yano, Yoshio Tanji, Masaya Nomura
BACKGROUND: Following unilateral breast cancer surgery, mastopexy and reduction of the unaffected breast are often performed to obtain symmetrical breasts. The use of implants in breast reconstruction results in a nonptotic breast. To achieve symmetry following the procedure, the unaffected side should be nonptotic too. However, no study has yet reported any indices for the design of mastopexy and reduction in this direction. We present a new method of preoperative design that uses vertical breast measurements to form nonptotic breasts according to individual breast shapes...
October 26, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27873527/numerical-evaluation-of-scar-after-breast-reconstruction-with-abdominal-advancement-flap
#14
M Kovář, L Čapek, L Vítová, M Molitor
BACKGROUND: The treatment of breast cancer has developed a lot during the last decade, nevertheless it still remains a considerable social and economical problem all over the world. The choice of the surgical procedure depends on a patients protocol and the surgeons preferences. The aim of this study is to evaluate the stress on the scar after breast reconstruction. METHODS: Mathematical modeling of the sutured skin flap used for breast implant placement was divided into the following two steps...
2016: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/27867298/prophylactic-bilateral-nipple-sparing-mastectomy-and-a-staged-breast-reconstruction-technique-preliminary-results
#15
Thierry Tondu, Filip Thiessen, Wiebren A A Tjalma
More high-risk women with breast cancer are identified using genetic testing at a younger age. These young women often opt for prophylactic surgery. Most patients are reluctant for extra donor-site scars besides infections and necrosis. In order to reduce these risks, a two-stage breast reconstruction technique is used for high-risk women with large or ptotic breasts. We presume that this procedure will reduce the risk of skin envelope and nipple-areola complex (NAC) necrosis to less than 1%. In the first stage, an inferior pedicle reduction is performed to obtain large volume reduction with maximal safety for the NAC...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27866726/trends-in-mastectomy-and-reconstruction-for-breast-cancer-a-twelve-year-experience-from-a-tertiary-care-center
#16
James M Chang, Heidi E Kosiorek, Amylou C Dueck, William J Casey, Alanna M Rebecca, Raman Mahabir, Samir H Patel, Sameer R Keole, William W Wong, Carlos E Vargas, Michele Y Halyard, Richard J Gray, Nabil Wasif, Chee-Chee H Stucky, Barbara A Pockaj
BACKGROUND: Many surgical options exist for breast cancer, including breast conserving therapy (BCT), mastectomy with reconstruction (MAST+RECON) or without reconstruction (MAST). Long-term results regarding oncologic outcomes are few and primarily retrospective studies. METHODS: A retrospective review of a prospectively collected database of patients undergoing breast surgery for breast cancer from 2002 to 2014 was performed. Patients were separated into 3 time periods for analysis: 2002 to 2005, 2006 to 2009, and 2010 to 2014...
September 29, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27864694/the-effect-on-surgical-complications-of-bevacizumab-added-to-neoadjuvant-chemotherapy-for-breast-cancer-nrg-oncology-nsabp-protocol-b-40
#17
Harry D Bear, Gong Tang, Priya Rastogi, Charles E Geyer, Christine K Zoon, Kelley M Kidwell, André Robidoux, Luis Baez-Diaz, Adam M Brufsky, Rita S Mehta, Louis Fehrenbacher, James A Young, Francis M Senecal, Rakesh Gaur, Richard G Margolese, Paul T Adams, Howard M Gross, Joseph P Costantino, Soonmyung Paik, Sandra M Swain, Eleftherios P Mamounas, Norman Wolmark
BACKGROUND: NRG Oncology/NSABP trial B-40 tested the impact of adding bevacizumab (bev) to neoadjuvant chemotherapy for operable breast cancer. Secondary endpoints included rates of surgical complications after surgery in patients who did or did not receive bev. METHODS: A total of 1206 women with HER2-negative operable breast cancer were randomly assigned to receive one of three different docetaxel-plus-anthracycline-based regimens, without or with bev (15 mg/kg every 3 weeks) for the first 6 of 8 cycles and for 10 doses postoperatively...
November 18, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27863718/the-impact-of-immediate-breast-reconstruction-after-mastectomy-on-time-to-first-adjuvant-treatment-in-women-with-breast-cancer-in-a-community-setting
#18
L R Henry, L L Morris, R Downs, R E Schwarz
BACKGROUND: The impact of immediate breast reconstruction on the time to first adjuvant therapy is controversial. METHODS: Retrospective study design comparing time to first treatment in women undergoing mastectomy with and without immediate reconstruction in a community cancer center. RESULTS: Seventy-six cases fit inclusion criteria of which 44 (58%) underwent mastectomy with immediate reconstruction. Women undergoing immediate reconstruction were younger, had more bilateral mastectomies and had fewer prior breast procedures...
November 8, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27861758/method-of-breast-reconstruction-and-the-development-of-lymphoedema
#19
K-T Lee, S I Bang, J-K Pyon, J H Hwang, G-H Mun
BACKGROUND: Several studies have demonstrated an association between immediate autologous or implant-based breast reconstruction and a reduced incidence of lymphoedema. However, few of these have focused specifically on whether the reconstruction method affects the development of lymphoedema. The study evaluated the potential impact of breast reconstruction modality on the incidence of lymphoedema. METHODS: Outcomes of women with breast cancer who underwent mastectomy and immediate reconstruction using an autologous flap or a tissue expander/implant between 2008 and 2013 were reviewed...
November 14, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27860475/-new-diagnostic-imaging-technique-shear-wave-elastography
#20
M Zemanová
Shear wave elastography (SWE) is a new non-invasive diagnostic imaging technique, that maps the elastic properties of tissues. Nowadays this modality develops increasingly in medicine across its disciplines and opens a new era of high-quality ultrasound examination because it increases the specificity and thus improves diagnostic assurance. This method is similar to manual palpation, shows elastic properties of biological tissues and provides a kind of reconstruction of the internal structure of soft tissues based on measurement of the response of tissue compression...
2016: Ceská a Slovenská Oftalmologie
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