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Breast Cancer, Breast Reconstruction

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https://www.readbyqxmd.com/read/28927044/isolation-and-characterization-of-adult-mammary-stem-cells-from-breast-cancer-adjacent-tissues
#1
Ai-Ping Shi, Zhi-Min Fan, Ke-Wei Ma, Yan-Fang Jiang, Lei Wang, Ke-Wei Zhang, Shi-Bo Fu, Ning Xu, Zhi-Ru Zhang
Normal adult mammary stem cells (AMSCs) are promising sources for breast reconstruction, particularly following the resection of breast tumors. However, carcinogenic events can potentially convert normal AMSCs to cancer stem cells, posing a safety concern for the use of AMSCs for clinical tissue regeneration. In the present study, AMSCs and autologous primary breast cancer cells were isolated and compared for their ability to differentiate, their gene expression profile, and their potential to form tumors in vivo...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28923310/factors-associated-with-specific-diagnostic-and-statistical-manual-of-mental-disorders-fourth-edition-sexual-dysfunctions-in-breast-cancer-survivors-a-study-of-patients-and-their-partners
#2
Susanna B Hummel, Daniela E E Hahn, Jacques J D M van Lankveld, Hester S A Oldenburg, Eva Broomans, Neil K Aaronson
BACKGROUND: Many women develop sexual problems after breast cancer (BC) treatment. Little is known about BC survivors with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) sexual dysfunction and their partners, and the factors associated with their sexual functioning. AIM: To evaluate (i) patient-related and clinical factors associated with (a) specific DSM-IV sexual dysfunctions and (b) level of sexual functioning and sexual distress as reported by BC survivors and (ii) the association between the sexual functioning of BC survivors and that of their partners...
September 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28922321/-patient-reported-outcomes-following-breast-conservation-therapy-and-barriers-to-referral-for-partial-breast-reconstruction
#3
Sebastian Q Vrouwe, Ron B Somogyi, Laura Snell, Catherine McMillan, Danny Vesprini, Joan E Lipa
BACKGROUND: The purpose of this study was to evaluate the self-reported aesthetic outcome of breast conservation therapy (BCT) in a generalized sample of patients, and to describe potential barriers to referral for partial breast reconstruction. METHODS: Consecutive BCT patients completing radiotherapy over a one-year period at a regional cancer centre were identified. Eligible patients were contacted via mail/email and invited to participate. Participants completed the BREAST-Q BCT module along with a questionnaire examining feelings about breast reconstruction...
September 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28918997/tolerance-of-latissimus-dorsi-in-immediate-breast-reconstruction-without-implant-to-radiotherapy
#4
G Berthet, C Faure, M A Dammacco, C Vermesch, E Delay, C Ho Quoc, N Carrabin
INTRODUCTION: Immediate breast reconstruction (IBR) improves the quality of life of patients who undergo mastectomy. The latissimus dorsi flap (LDF) method provides particularly good aesthetic results, but its tolerance to subsequent radiotherapy remains unclear. We thus sought to assess tolerance and esthetic results and satisfaction, as reported by patients who underwent IBR by LDF with or without subsequent radiotherapy. MATERIALS AND METHODS: We performed a retrospective case-control study in a population of women who were diagnosed with breast cancer between January 1999 and January 2014 and who had mastectomies with IBR by LDF without prostheses...
August 18, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28918365/review-of-breast-augmentation-and-reconstruction-for-the-radiologist-with-emphasis-on-mri
#5
REVIEW
Lauren A Green, Jillian A Karow, Jordan E Toman, Antonella Lostumbo, Karen Xie
It is imperative to continue screening for breast cancer and/or detect tumor recurrence in patients after they have undergone breast augmentation or reconstruction. As there is an increasing role for both screening and diagnostic imaging of the post-operative breast, it is important for the radiologist to be familiar with the commonly performed surgical techniques in breast augmentation and reconstruction. Imaging of the augmented and reconstructed breast, as well as complications, will be reviewed with a focus on Magnetic Resonance Imaging (MRI)...
August 25, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28917935/trends-in-post-mastectomy-breast-reconstruction-types-at-a-breast-cancer-tertiary-referral-centre-before-and-after-introduction-of-acellular-dermal-matrices
#6
Hadyn K N Kankam, George J M Hourston, Laura J Fopp, John R Benson, Sarah L Benyon, Michael S Irwin, Amit Agrawal, Parto Forouhi, Charles M Malata
BACKGROUND: Reconstructive breast surgery has continued to evolve over the last decade with a key change being the adoption of acellular dermal matrices (ADMs) as an adjunct for implant-based procedures. This retrospective observational study assesses the effect of ADMs on post-mastectomy reconstructive practice performed in a single institution. METHODS: We conducted a review of all patients undergoing breast reconstruction at a University Teaching Hospital for an 18-month period before and after adopting ADMs...
August 31, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28894930/oncological-safety-and-technical-feasibility-of-nipple-sparing-mastectomy-for-breast-cancer-the-hong-kong-experience
#7
Yolanda Ho-Yan Chan, Wai-Ming Yau, Polly Suk-Yee Cheung
BACKGROUND: Nipple-sparing mastectomy (NSM) has gained widespread popularity in recent years. Nonetheless, patient selection, technical consideration and oncological safety of its extension to breast cancer treatment remain uncertain. Few publications have reviewed the application of NSM in Asian populations. METHODS: We retrospectively reviewed 91 women with malignant breast tumours, who underwent 97 NSM in Hong Kong Sanatorium and Hospital from 2009 to 2015. Breast cancer patients who required mastectomy and opted for immediate reconstruction were considered for NSM if they showed no obvious nipple involvement clinically...
September 11, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28894848/risk-reduction-strategies-in-breast-cancer-prevention
#8
REVIEW
Mauricio Costa, Paula Saldanha
Evaluating the risk of breast cancer makes it possible to identify women with a high risk of developing breast cancer in the future. Adopting a healthier lifestyle, involving diet and exercise, is one way of reducing this risk-but there are other, non-modifiable risk factors, such as family history, genetics and diagnosis of premalignant lesions. In this high-risk population, the tracking must be rigorous and involve the participation of the patient herself, earlier and more frequent clinical assessment, and the use of imaging screening...
July 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/28894513/diagnostic-methods-risk-factors-prevention-and-management-of-breast-cancer-related-lymphedema-past-present-and-future-directions
#9
Hoda E Sayegh, Maria S Asdourian, Meyha N Swaroop, Cheryl L Brunelle, Melissa N Skolny, Laura Salama, Alphonse G Taghian
PURPOSE OF REVIEW: Breast cancer-related lymphedema (BCRL) is a chronic, adverse, and much feared complication of breast cancer treatment, which affects approximately 20% of patients following breast cancer treatment. BCRL has a tremendous impact on breast cancer survivors, including physical impairments and significant psychological consequences. The intent of this review is to discuss recent studies and analyses regarding the risk factors, diagnosis, prevention through early screening and intervention, and management of BCRL...
June 2017: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/28886199/quantitative-analysis-and-comparison-of-3d-morphology-between-viable-and-apoptotic-mcf-7-breast-cancer-cells-and-characterization-of-nuclear-fragmentation
#10
Yuhua Wen, Zhan Chen, Jianfen Lu, Elizabeth Ables, Jean-Luc Scemama, Li V Yang, Jun Q Lu, Xin-Hua Hu
Morphological changes in apoptotic cells provide essential markers for defining and detection of apoptosis as a fundamental mechanism of cell death. Among these changes, the nuclear fragmentation and condensation have been regarded as the important markers but quantitative characterization of these changes is yet to be achieved. We have acquired confocal image stacks of 206 viable and apoptotic MCF-7 cells stained by three fluorescent dyes. Three-dimensional (3D) parameters were extracted to quantify and compare their differences in morphology...
2017: PloS One
https://www.readbyqxmd.com/read/28878901/breast-reconstruction-in-pregnancy-a-case-report-of-multidisciplinary-team-approach-in-immediate-autologous-flap-reconstruction-for-pregnancy-associated-breast-cancer
#11
Prakasit Chirappapha, Panya Thaweepworadej, Nuttapong Ngamphaiboon, Matchuporn Sukprasert, Thongchai Sukarayothin, Monchai Leesombatpaiboon
This report presents the results of immediate breast reconstruction with autologous flap in Pregnancy-associated breast cancer (PABC). There was no obstetrics and surgical complications in our report. Immediate breast reconstruction can be performed in PABC after a careful selection. Multidisciplinary team approach is the key in managing these groups of patients.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28876635/the-surgical-management-of-central-breast-tumours-at-a-specialist-breast-unit-in-johannesburg-south-africa
#12
L Van Schalkwyk, C A Benn, K Bergstrom
BACKGROUND: Central breast tumours are defined as tumours in the retroareolar area, or within 1.5-2.0 cm from the areolar edge. In the past, breast conservation therapy (BCT) for central breast tumours was considered controversial due to concerns regarding oncologic safety and cosmesis. Recent evidence does however suggest that oncoplastic techniques offer a cosmetically acceptable and safe alternative to mastectomy in these tumours. METHOD: Patients with central breast tumours (invasive and in situ) were identified from a breast cancer database of 431 patients who presented to the Netcare Breast Care Centre in Johannesburg over a one-year period (June 2015-June 2016)...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876589/reconstruction-in-locally-advance-breast-cancer-who-what-and-when
#13
L Van Schalkwyk, C Benn, K Bergstrom
BACKGROUND: Locally advanced breast cancer (LABC) is defined as the most advanced stage of non-metastatic breast cancer. While breast reconstruction is not contraindicated in this subset of patients, the decision-making process is influenced by several considerations, including recurrence risk and the need for and timing of adjuvant therapy such as radiotherapy. This retrospective analysis investigates the reconstructive procedures performed on women presenting with locally advanced breast cancer at the Netcare Breast Care Centre (NCBC) in Johannesburg...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28871582/pyoderma-gangrenosum-after-breast-mastectomy-and-primary-rectus-abdominis-flap-reconstruction
#14
Yasuhiro Suzuki, Kozue Yokoyama, Mayako Terao, Toru Morioka, Banri Tsuda, Naoki Niikura, Takuho Okamura, Eri Yamada, Kotaro Imagawa, Tadashi Akamatsu, Yutaka Tokuda, Nobue Kumaki
Pyoderma gangrenosum is an intractable disease of unknown cause involving recurrent ulcerative lesions on the skin, and may accompany ulcerative colitis, rheumatoid arthritis, leukemia, systemic lupus erythematosus, and other conditions. Here, we report a rare case of pyoderma gangrenosum in the thoracic abdomen following post-mastectomy reconstructive surgery. A 39-year-old presented at the hospital with a complaint of left papilla erosion. Skin biopsy at the site revealed invasive skin cancer, with Paget-like progression in the cancerous nipple and suspected malignancy of skin appendages...
September 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/28870056/-application-of-autologous-fat-grafting-in-breast-reconstruction
#15
L Cai, X F Han, B Q Wang, F C Li
Objective: To observe the outcome of breast reconstruction with autologous fat grafting in the patients following treatment for breast cancer. Methods: The clinical data of 22 patients after breast cancer modified radical mastectomy with fat grafting for breast reconstruction from January 2012 to March 2015 at Department of Body Contouring and Liposuction Center of Plastic Surgery, Hospital of Peking Union Medical College were analyzed retrospectively. The age of 22 patients (all female) was 28 to 54 years...
September 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28864887/patients-experience-of-breast-reconstruction-after-mastectomy-and-its-influence-on-postoperative-satisfaction
#16
Jana L Schmidt, Cordula M Wetzel, Klaus W Lange, Norbert Heine, Olaf Ortmann
PURPOSE: Breast cancer patients have the option to choose a breast reconstruction after mastectomy. A range of studies have postulated that patients' individually appraised significance of their breast is an important factor in the decision for or against breast reconstruction. This study explored the individually perceived significance of the breast among patients with and without breast reconstruction and its correlation with postoperative satisfaction. METHODS: Ten patients without breast reconstruction, and ten patients with immediate breast reconstruction after mastectomy participated in the study...
September 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28862115/new-language-and-old-problems-in-breast-cancer-radiotherapy
#17
Ion Christian Chiricuţă
New developments in breast cancer radiotherapy make possible new standards in treatment recommandations based on international guidelines. Developments in radiotherapy irradiation techniques from 2D to 3D-Conformal RT and to IMRT (Intensity Modulated Arc Therapy) make possible to reduce the usual side effects on the organs at risk as: skin, lung, miocard, bone, esophagus and brahial plexus. Dispite of all these progresses acute and late side effects are present. Side effects are as old as the radiotherapy was used...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28862114/immediate-delayed-autologous-ideal-breast-reconstruction-with-the-diep-flap
#18
Sonia Fertsch, Beatrix Munder, Mazen Hagouan, Tino Schulz, Oliver Thamm, Peter Stambera, Alina Abu-Ghazaleh, Julia Schaberick, Christoph Andree
Background: The most common cancer worldwide in women is breast cancer. The increasing number of cases each year, requires a novel curative approach that can combine oncological treatments and breast reconstruction yielding a pleasing and aesthetic breast that is a definitive and long lasting solution. Thus, the Immediate-DElayed AutoLogous (IDEAL) breast reconstruction principle was created to hold up to the standards of the needs of contemporary women. METHOD: The IDEAL protocol for breast reconstruction was developed in our department in cooperation with our breast surgery unit and describes a two-stage approach that implicates neoadjuvant radio-/ chemotherapy treatment regimes and tumor staging before the mastectomy in order to avoid post-mastectomy radiation...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28862113/immediate-versus-delayed-breast-reconstruction-for-postmastectomy-patients-controversies-and-solutions
#19
Cristina Iulia Filip, Cristian Radu Jecan, Laura Raducu, Tiberiu Paul Neagu, Ioan Petre Florescu
When considering breast reconstruction, two main decisions have to be made: optimal timing and appropriate reconstruction technique,that would best suit each patient, while also taking into consideration the complications and risks that these decisions might lead to. By careful patient selection and individualized breast reconstruction approach, the risks and complications of the procedure can be minimized, while attaining successful aesthetic outcomes and high patient satisfaction. Breast reconstruction can be performed in three different settings: immediate reconstruction - at the time of mastectomy; delayed reconstruction " after the completion of the adjuvant treatment and in a delayed-immediate setting that uses both previous methods" includes tissue expansion at the time of mastectomy and definitive reconstruction performed after completion of the adjuvant treatment...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28862112/indications-of-the-magnetic-resonance-method-in-breast-pathology
#20
Adina Chiriţă
The high incidence of breast cancer is a known fact. The 5-year survival rate for women with correctly treated breast cancer is 90% around the world, and 50% in Romania, respectively. Correct diagnostic evaluation of the breasts allows for a competent therapeutic management. The primary diagnosis of breast cancer includes clinical examination of the breasts, breast ultrasound and mammography. Magnetic resonance imaging (MRI) examination is not a first line type of investigation, but targeted to selected patient groups...
July 2017: Chirurgia
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