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Breast Cancer, Breast Reconstruction

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https://www.readbyqxmd.com/read/29334363/macrophage-membrane-coated-iron-oxide-nanoparticles-for-enhanced-photothermal-tumor-therapy
#1
Qian-Fang Meng, Lang Rao, Minghui Zan, Ming Chen, Guang-Tao Yu, Xiaoyun Wei, Zhuhao Wu, Yue Sun, Shi Shang Guo, Xing-Zhong Zhao, Fu-Bing Wang, Wei Liu
Nanotechnology possesses the potential to revolutionize the diagnosis and treatment of tumors. The ideal nanoparticles used for in vivo cancer therapy should own long blood circulation and active cancer targeting. Additionally, they should be innoxious and invisible to the immune system. Here, we developed a biomimetic nanoplatform with the above properties for cancer therapy. Macrophage membranes were reconstructed into vesicles and then coated onto magnetic iron oxide nanoparticles (Fe3O4 NPs). Inherited from the Fe3O4 core and the macrophage membrane shell, the resulting Fe3O4@MM NPs exhibited good biocompatibility, immune evasion, cancer targeting, and light-to-heat conversion capabilities...
January 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29330268/pelvic-and-buttock-hypoplasia-reconstructed-with-anatomical-breast-implants
#2
Felicity Page, Ayad Harb, Garth Titley
Radiation therapy is used in the management of a number of childhood cancers and can have significant effects on skeletal growth. We present the case of a 35-year-old woman who developed a hypoplastic pelvis and buttocks following radiotherapy for rhabdomyosarcoma of the vagina at the age of 2. At the age of 25, the patient underwent bilateral buttock augmentation with a two-stage reconstruction using tissue expansion followed by definitive augmentation with anatomical breast implant insertion. The patient continues to have a satisfactory outcome 10 years following reconstruction, having undergone a single uplift procedure and exchange of implants through the original incision 9 years postoperatively...
January 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29325808/dutch-breast-reconstruction-guideline
#3
REVIEW
Marc A M Mureau
Treatment of breast cancer is complex and multidisciplinary by nature, with protocols that are updated continuously. During preoperative multidisciplinary team meetings, regularly there is discussion between team members regarding optimal timing and type of breast reconstruction, due to conflicting interests of oncological and reconstructive treatments. Therefore, a multidisciplinary, evidence-based guideline for breast reconstruction in women undergoing breast conserving therapy or mastectomy for breast cancer, or following prophylactic mastectomy was developed by a multidisciplinary working group...
December 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29324933/brachytherapy-in-soft-tissue-tumours-an-interdisciplinary-challenge
#4
Silvanie Volz, Konstantinos Kalousis, Jung In Song, Tobias Kisch, Eike Wenzel, Peter Mailänder
OBJECTIVE: Interdisciplinary work including surgery and additive radiotherapy is often needed for the therapy of tumours. Beneath this, brachytherapy is an important part of the radiotherapy. It was first used over 100 years ago and is in regular use after the development of afterload technology in the early 1970s. Today it is often used in different tumour therapies, for example in soft tissue sarcoma or breast tumours, in order to decrease the risk of local recurrence. Concerning its benefits, higher doses could be used because of the localized effect with equivalent local control rate and less toxicity of treatment...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29320921/benefits-and-risks-with-acellular-dermal-matrix-adm-and-mesh-support-in-immediate-breast-reconstruction-a-systematic-review-and-meta-analysis
#5
Håkan Hallberg, Svanheidur Rafnsdottir, Gennaro Selvaggi, Annika Strandell, Ola Samuelsson, Ida Stadig, Therese Svanberg, Emma Hansson, Richard Lewin
In modern implant-based immediate breast reconstruction, it has become common to use biological acellular dermal and synthetic matrices in combination with a tissue expander or an implant. The aim of this systematic review was to examine differences in recurrence of cancer, impact on oncological treatment, health related quality of life, complications and aesthetic outcome between matrix and no matrix in immediate breast reconstruction. Systematic searches, data extraction and assessment of methodological quality were performed according to predetermined criteria...
January 10, 2018: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/29319579/how-big-is-too-big-pushing-the-obesity-limits-in-microsurgical-breast-reconstruction
#6
Jamie A Spitz, Perry S Bradford, Frank Aguilar, Sergey Y Turin, Marco F Ellis
PURPOSE: Obesity is a major public health concern in the United States, affecting nearly 79 million people. There have been promising results performing microvascular breast reconstruction in patients with obesity; however, the definition of obesity is often poorly defined or does not extend above a body mass index (BMI) of 35. Our goal was to examine outcomes of microvascular breast reconstruction in this questionably more risky population. METHODS: A retrospective review from 2013 to 2016 was performed of 2 surgeons' experience with abdominally based microvascular breast reconstructions...
February 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29318956/improvement-in-existing-chest-wall-irregularities-during-breast-reconstruction
#7
Katherine M Huber, Amanda Zimmerman, Deniz Dayicioglu
Mastectomies for both cancer resection and risk reduction are becoming more common. Existing chest wall irregularities are found in these women presenting for breast reconstruction after mastectomy and can pose reconstructive challenges. Women who desired breast reconstruction after mastectomy were evaluated preoperatively for existing chest wall irregularities. Case reports were selected to highlight common irregularities and methods for improving cosmetic outcome concurrently with breast reconstruction procedures...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29316048/does-response-to-neo-adjuvant-chemotherapy-impact-breast-reconstruction
#8
Michael R Cassidy, Emily C Zabor, Michelle Stempel, Babak Mehrara, Mary L Gemignani
Neo-adjuvant chemotherapy (NAC) is administered in breast cancer treatment for downstaging of disease. Here, we determined the impact of response to NAC on breast reconstruction uptake. A prospective NAC and mastectomy database with or without reconstruction were reviewed with IRB approval. Univariable analyses were conducted using Kruskal-Wallis or Fisher's exact tests. Multivariable logistic regression was used to adjust for potential confounders. We identified 271 patients with unilateral breast cancer receiving NAC and either unilateral or bilateral mastectomy from 9/2013 to 5/2016...
January 8, 2018: Breast Journal
https://www.readbyqxmd.com/read/29305307/role-of-age-tumor-grade-and-radiation-therapy-on-immediate-postmastectomy-breast-reconstruction
#9
Karishma G Reddy, Paula D Strassle, Kandace P McGuire
BACKGROUND: Despite the psychological benefits and oncologic safety of postmastectomy breast reconstruction, most breast cancer patients do not undergo reconstruction. To better understand the patterns of breast reconstruction usage, it is important to identify the clinicopathologic factors associated with immediate breast reconstruction (IBR), and whether modification of the reconstruction incidence when stratified by patient- or cancer-related factors exists in the breast cancer population...
December 7, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29302735/a-new-human-derived-acellular-dermal-matrix-for-breast-reconstruction-available-for-the-european-market-preliminary-results
#10
Secondo Folli, Annalisa Curcio, Davide Melandri, Elena Bondioli, Nicola Rocco, Giuseppe Catanuto, Fabio Falcini, Valeria Purpura, Matteo Mingozzi, Federico Buggi, Francesco Marongiu
INTRODUCTION: The introduction of acellular dermal matrices (ADMs) contributed to the growing diffusion of direct-to-implant breast reconstruction (DTI-BR) following mastectomy for breast cancer. According to specific legislations, European specialists could not benefit from the use of human-derived ADMs, even though most evidence in the literature are available for this kind of device, showed optimal outcomes in breast reconstruction. The Skin Bank of the Bufalini Hospital (Cesena, Italy) obtained in 2009 the approval for the production and distribution of a new human cadaver-donor-derived ADM (named with the Italian acronym, MODA, for matrice omologa dermica acellulata) from the Italian National Transplant Center and National Health Institute...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29302489/enhancing-breast-projection-in-autologous-reconstruction-using-the-st-andrew-s-coning-technique-and-3d-volumetric-analysis
#11
Michael P Chae, Warren Matthew Rozen, Nakul Gamanlal Patel, David J Hunter-Smith, Venkat Ramakrishnan
Background: An increasing number of women undergo mastectomy for breast cancer and post-mastectomy autologous breast reconstruction has been shown to significantly improve the psychosexual wellbeing of the patients. A goal of treatment is to achieve symmetry and projection to match the native breast, and/or the contralateral breast in the case of a unilateral reconstruction. Autologous reconstruction, particularly with the deep inferior epigastric artery perforator (DIEP) flap, is particularly advantageous as it can be manipulated to mimic the shape and turgor of the native breast...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29302486/early-multicentre-experience-of-pre-pectoral-implant-based-immediate-breast-reconstruction-using-braxon%C3%A2
#12
Sadaf Jafferbhoy, Mihir Chandarana, Maria Houlihan, Rishikesh Parmeshwar, Sankaran Narayanan, Soni Soumian, Simon Harries, Lucie Jones, Dayalan Clarke
Background: The last two decades have seen significant changes in surgical management of breast cancer. The offer of immediate breast reconstruction (IBR) following mastectomy is currently standard practice. Skin sparing and nipple sparing mastectomy with implant-based IBR have emerged as oncologically safe treatment options. Prepectoral implant placement and complete coverage of implant with acellular dermal matrix (ADM) eliminates the need to detach the muscle from underlying chest wall in contrast to the subpectoral technique...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29301932/a-post-reconstruction-harmonization-method-for-multicenter-radiomic-studies-in-pet
#13
Fanny Orlhac, Sarah Boughdad, Cathy Philippe, Hugo Stalla-Bourdillon, Christophe Nioche, Laurence Champion, Michaël Soussan, Frédérique Frouin, Vincent Frouin, Irène Buvat
Introduction: Several reports have shown that radiomic feature values are affected by the acquisition and reconstruction parameters, thus hampering multicenter studies. We propose a method to standardize features measured from Positron Emission Tomography (PET) images obtained using different imaging protocols to remove the center effect while preserving patient-specific effects. Methods: Pre-treatment 18F-FDG-PET images of patients with breast cancer were included. In Department A, 63 patients were scanned using a Gemini Time-Of-Flight-PET/Computed-Tomography scanner including 16 triple-negative lesions (TN)...
January 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29287289/-current-german-and-american-guidelines-for-autologous-fat-grafting-a-transatlantic-comparison
#14
G Felix Broelsch, Sören Könneker, Ramin Ipaktchi, Peter M Vogt
CLINICAL PROBLEM: The renewed clinical interest in fat grafting for both reconstructive and aesthetic purposes prompted the American Society of Plastic Surgeons to establish a Fat Graft Task Force (AFGT) in 2009. Moreover, in 2015, the German Society of Plastic, Reconstructive and Aesthetic Surgeons (DGPRÄC), in cooperation with three relevant medical societies (DDG, DGMKG, DGGG), formulated statements on the provision of strategies for patient management and to guide physicians in clinical decision making, on the basis of the scientific literature, clinical experience and current laws...
December 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29286493/twenty-five-years-of-the-national-academy-of-medical-sciences-of-ukraine-progress-and-priorities-for-future-of-radiation-medicine-and-biology
#15
D Bazyka
After the creation of the Academy of Medical Sciences of Ukraine in 1993 the Research Center for Radiation Medicine was among the first institutions to join the Academy (fig. 1). Estab lishing the Academy was among the first steps of the independent Ukrainian government and aimed to provide a high level health care for population. It was extremely needed for the minimization of Chornobyl medical consequences. This choice was related to a growing recognition of the scientific research in fulfilling the Сenter's mission - study of the effects of low dose radiation on human body and radiation protection of the exposed population...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29283514/an-animal-model-of-local-breast-cancer-recurrence-in-the-setting-of-autologous-fat-grafting-for-breast-reconstruction
#16
Wakako Tsuji, Jolene E Valentin, Kacey G Marra, Albert D Donnenberg, Vera S Donnenberg, J Peter Rubin
Autologous fat grafting after breast cancer surgery is commonly performed, but concerns about oncologic risk remain. To model the interaction between fat grafting and breast cancer cells, two approaches were employed. In the first approach, graded numbers of viable MDA-MB-231 or BT-474 cells were admixed directly into human fat grafts and injected subcutaneously into immune-deficient mice to determine if the healing graft is a supportive environment for the tumor. In the second approach, graded doses of MDA-MB-231 cells were suspended in Matrigel and injected into the mammary fat pads of mice...
January 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29283496/quantitative-assessment-of-cancer-cell-morphology-and-motility-using-telecentric-digital-holographic-microscopy-and-machine-learning
#17
Van K Lam, Thanh C Nguyen, Byung M Chung, George Nehmetallah, Christopher B Raub
The noninvasive, fast acquisition of quantitative phase maps using digital holographic microscopy (DHM) allows tracking of rapid cellular motility on transparent substrates. On two-dimensional surfaces in vitro, MDA-MB-231 cancer cells assume several morphologies related to the mode of migration and substrate stiffness, relevant to mechanisms of cancer invasiveness in vivo. The quantitative phase information from DHM may accurately classify adhesive cancer cell subpopulations with clinical relevance. To test this, cells from the invasive breast cancer MDA-MB-231 cell line were cultured on glass, tissue-culture treated polystyrene, and collagen hydrogels, and imaged with DHM followed by epifluorescence microscopy after staining F-actin and nuclei...
December 28, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29280859/outcome-analysis-of-free-flap-salvage-in-outpatients-presenting-with-microvascular-compromise
#18
Rene D Largo, Jesse C Selber, Patrick B Garvey, Edward I Chang, Matthew M Hanasono, Peirong Yu, Charles E Butler, Donald P Baumann
BACKGROUND: Extensive flap salvage attempts are routinely performed in patients with late-onset flap vascular crisis despite low flap survival rates. A knowledge gap exists in management of compromised free flaps in patients who present with perfusion-related complications after hospital discharge. METHODS: A retrospective review of 7443 free flaps used in 7128 cancer patients at a single institution from January of 2001 to March of 2015 was performed. RESULTS: Of 7443 free flap reconstructions, 856 patients (12 percent) were taken back to the operating room...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29260537/diffuse-optical-tomography-using-semiautomated-coregistered-ultrasound-measurements
#19
Atahar Mostafa, Hamed Vavadi, K M Shihab Uddin, Quing Zhu
Diffuse optical tomography (DOT) has demonstrated huge potential in breast cancer diagnosis and treatment monitoring. DOT image reconstruction guided by ultrasound (US) improves the diffused light localization and lesion reconstruction accuracy. However, DOT reconstruction depends on tumor geometry provided by coregistered US. Experienced operators can manually measure these lesion parameters; however, training and measurement time are needed. The wide clinical use of this technique depends on its robustness and faster imaging reconstruction capability...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29259059/protocol-for-the-brecar-study-a-prospective-cohort-follow-up-on-the-impact-of-breast-reconstruction-timing-on-health-related-quality-of-life-in-women-with-breast-cancer
#20
Maria Herrera de la Muela, Enrique García López, Laura Frías Aldeguer, Paloma Gómez-Campelo
INTRODUCTION: The completion of postmastectomy breast reconstruction (BR) in women with breast cancer can last from months to years, and to our knowledge, there is a lack of studies that analyse how the different types and times of reconstruction impact on the patient's quality of life and psychosocial adjustment.The primary aim of the BREast Cancer Reconstruction (BRECAR Study) is twofold. First, to describe health-related quality of life (HRQoL), overall satisfaction with surgery and psychological impact (body image, self-esteem, depression and anxiety) on women who will have undergone a mastectomy with planned BR, considering the varied timing of BR procedures (immediate BR (iBR), delayed BR (dBR) and two-stage BR (2sBR))...
December 19, 2017: BMJ Open
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