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Sarcoma retroperitoneal

Jeong Il Yu, Do Hoon Lim, Hee Chul Park, Heerim Nam, Bo Kyoung Kim, Sung-Joo Kim, Jae Berm Park
We investigated the efficacy and safety of a tissue expander (TE) for adjuvant radiotherapy (RT) of resected retroperitoneal sarcoma (RPS).This study was conducted with 37 patients with RPS who received resection with or without TE insertion followed by RT from August 2006 to June 2012 at Samsung Medical Center. Among the 37 patients, TE was inserted in 19. The quality of TE insertion was evaluated according to the correlation of clinical target volume and retroperitoneal surface volume covered by TE and was defined as follows: excellent, ≥85%; good, 70% to 85%; fair, 50% to 70%; and poor, <50%...
July 2016: Medicine (Baltimore)
Imen Ben Salha, Shane Zaidi, Jonathan Noujaim, Aisha B Miah, Cyril Fisher, Robin L Jones, Khin Thway
Dedifferentiated liposarcoma (DDL) is a histologically pleomorphic sarcoma, traditionally defined as well-differentiated liposarcoma with abrupt transition to high grade, non-lipogenic sarcoma. It can occur as part of recurrent well-differentiated liposarcoma, or may arise de novo. DDL most frequently occurs within the retroperitoneum, and while it is prone to local recurrence, it usually has a lower rate of metastasis than other pleomorphic sarcomas. We describe a case of retroperitoneal dedifferentiated liposarcoma in a 63-year-old male, who showed MDM2 amplification with fluorescence in situ hybridization, which displayed unusually aggressive behavior, with brain, lung and subcutaneous soft tissue metastases...
September 5, 2016: Rare Tumors
Hong Seok Lee, Jeong Il Yu, Do Hoon Lim, Sung Joo Kim
PURPOSE: To evaluate the benefit of adjuvant radiation therapy (RT) for retroperitoneal liposarcoma (RPLS) following gross tumor removal. MATERIALS AND METHODS: We reviewed 77 patients with primary RPLS surgically treated between January 2000 and December 2013. Cases with gross residual disease were excluded. Tumor grade was evaluated according to the French Federation of Cancer Centers Sarcoma Group (FNCLCC) system. Adjuvant RT was delivered to 32 patients (42%) using external beam RT alone...
September 2016: Radiation Oncology Journal
B L Ecker, M G Peters, M T McMillan, A J Sinnamon, P J Zhang, D L Fraker, W P Levin, R E Roses, G C Karakousis
BACKGROUND: Histological subtype influences both prognosis and patterns of treatment failure in retroperitoneal sarcoma. Previous studies on the efficacy of neoadjuvant radiotherapy (NRT) have incorporated multiple histological types with heterogeneous tumour biology. The survival impact of NRT specifically for patients with retroperitoneal liposarcoma is poorly defined. METHODS: Patients who underwent resection with curative intent for retroperitoneal liposarcoma and who received NRT or surgery alone were identified in the US National Cancer Data Base (2004-2013)...
September 29, 2016: British Journal of Surgery
T F DeLaney, Y L E Chen, J A Adams, S Hickey, D Wang, E H Baldini, K Bernstein, B Y Yeap, S M Hahn, G P Nielsen, E Choy, J T Mullen, S S Yoon
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
P Wong, Z Kassam, C Swallow, R Gladdy, P Chung, B O'Sullivan, J G Ringash, C N Catton
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
P Cosper, B VanTine, T A DeWees, J R Olsen, I Zoberi
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Shelly Loewenstein, Nir Lubezky, Eran Nizri, Meir Zemel, Yishai Levin, Alon Savidor, Osnat Sher, Joseph M Klausner, Guy Lahat
: Previous data demonstrated that high retroperitoneal visceral fat (VF) content increases retroperitoneal soft-tissue sarcoma (RSTS) local recurrence and patients mortality. Most RSTS tumors initiate and recur within VF. The objective of the current study was to evaluate potential paracrine effects of VF on RSTS. A xenograft model was used to evaluate in vivo effects of human VF on STS growth. Tissue explants were prepared from VF, and their conditioned medium (CM) was utilized for various in vitro experiments designed to evaluate growth, survival, migration and invasion of STS and endothelial cells...
September 12, 2016: Molecular Cancer Research: MCR
Wen-Zhe Fan, Li-Zhi Niu, Yu Wang, Xue-Hua Yao, Ying-Qiang Zhang, Guo-Sheng Tan, Jian-Yong Yang, Jia-Ping Li
PURPOSE: To evaluate the pain-alleviating effect of computed tomography (CT)-guided percutaneous cryoablation for recurrent retroperitoneal soft-tissue sarcomas (RPSs). MATERIALS AND METHODS: Data from 19 men and 20 women (median age, 50.3 y) with recurrent malignant RPS who underwent percutaneous cryoablation were reviewed retrospectively. A total of 50 tumors were treated by cryoablation, including a single tumor in 29 patients, 2 tumors in 9, and 3 tumors in 1...
September 8, 2016: Journal of Vascular and Interventional Radiology: JVIR
Ben Hazen, Andrei Cocieru
Retroperitoneal sarcomas are rare tumors, having an annual incidence of 0.3 to 0.4 new cases per 100,000 occupants. R0 resection is the cornerstone of therapy, with local control being integral for a favorable prognosis. We present a case of giant retroperitoneal liposarcoma treated with complete surgical resection.
September 9, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Guillaume Oldrini, Agnès Leroux, Guillaume Vogin, Maria Rios, Frédéric Marchal, François Sirveaux, Jean-Luc Verhaeghe, Sophie Renard-Oldrini, Grégory Lesanne, Julia Salleron, Philippe Henrot
INTRODUCTION: Suspicious lesions of sarcoma require preoperative biopsies. If surgical biopsies remain the gold standard, radioguided percutaneous microbiopsies are gaining an increasing importance. The purpose of this study was to compare histopathological results of percutaneous biopsies of soft tissues, trunk and retroperitoneal tumors with the histopathological results of operative specimens. METHODS: This is a retrospective study including 84 patients treated in our institution...
September 2, 2016: La Presse Médicale
Jürgen Dunst
No abstract text is available yet for this article.
September 5, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Aleksandr A Reznichenko
Background. The concomitant occurrence of a renal cell carcinoma and retroperitoneal sarcoma is extremely rare with only few cases being reported. Methods. We present a case of simultaneous renal cell carcinoma and exceptionally large size retroperitoneal sarcoma involving small intestine. Surgical resection of retroperitoneal sarcoma and simultaneous right nephrectomy were performed. Results. Patient developed recurrent and metastatic disease and underwent debulking surgery following by chemotherapy. Despite aggressive behavior of the retroperitoneal sarcomas, patient is currently (7 years after simultaneous resection and nephrectomy) recurrence-free...
2016: Case Reports in Surgery
Nicole A Larrier, Brian G Czito, David G Kirsch
Soft tissue sarcomas are rare mesenchymal cancers that pose a treatment challenge. Although small superficial soft tissue sarcomas can be managed by surgery alone, adjuvant radiotherapy in addition to limb-sparing surgery substantially increases local control of extremity sarcomas. Compared with postoperative radiotherapy, preoperative radiotherapy doubles the risk of a wound complication, but decreases the risk for late effects, which are generally irreversible. For retroperitoneal sarcomas, intraoperative radiotherapy can be used to safely escalate the radiation dose to the tumor bed...
October 2016: Surgical Oncology Clinics of North America
Rebecca A Gladdy, Abha Gupta, Charles N Catton
After diagnosis of retroperitoneal sarcoma (RPS), detailed imaging and multidisciplinary discussion should guide treatment including surgical resection and in select cases, neoadjuvant therapy. Local recurrence is common in RPS and is associated with grade, histologic subtype, completeness of resection, and size. As guidelines to standardize RPS patient management emerge, expert pathologic assessment and management in centers of excellence are benchmarks of quality of care. The efficacy of current chemotherapy is limited and there is a critical need to understand the molecular basis of sarcoma so that new drug therapies are developed...
October 2016: Surgical Oncology Clinics of North America
P Sargos, E Stoeckle, B Henriques de Figueiredo, M Antoine, M Delannes, A Mervoyer, G Kantor
The management of retroperitoneal sarcoma can be very challenging, and the quality of initial treatment strategy appears to be a crucial prognostic factor. En bloc surgery is currently the standard of care for these rare tumours and perioperative treatments such as chemotherapy or radiotherapy have not been validated yet. However, local-regional relapse constitutes the most common disease course. While adjuvant radiotherapy is less and less common due to gastrointestinal toxicities, preoperative radiation therapy offers numerous advantages and is being evaluated as part of a national multicentre phase II study (TOMOREP trial) and is the subject of a European randomized phase III study (STRASS trial)...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Vivek Verma, Steven H Lin, Charles B Simone, Minesh P Mehta
BACKGROUND: Proton beam radiotherapy (PBT) is frequently shown to be dosimetrically superior to photon radiotherapy (RT), though supporting data for clinical benefit are severely limited. Because of the potential for toxicity reduction in gastrointestinal (GI) malignancies, we systematically reviewed the literature on clinical outcomes (survival/toxicity) of PBT. METHODS: A systematic search of PubMed, EMBASE, abstracts from meetings of the American Society for Radiation Oncology, Particle Therapy Co-Operative Group, and American Society of Clinical Oncology was conducted for publications from 2000-2015...
August 2016: Journal of Gastrointestinal Oncology
Vicky Pham, Evita Henderson-Jackson, Matthew P Doepker, Jamie T Caracciolo, Ricardo J Gonzalez, Mihaela Druta, Yi Ding, Marilyn M Bui
BACKGROUND: Retroperitoneal sarcoma is rare. Using initial specimens on biopsy, a definitive diagnosis of histological subtypes is ideal but not always achievable. METHODS: A retrospective institutional review was performed for all cases of adult retroperitoneal sarcoma from 1996 to 2015. A review of the literature was also performed related to the distribution of retroperitoneal sarcoma subtypes. A meta-analysis was performed. RESULTS: Liposarcoma is the most common subtype (45%), followed by leiomyosarcoma (21%), not otherwise specified (8%), and undifferentiated pleomorphic sarcoma (6%) by literature review...
July 2016: Cancer Control: Journal of the Moffitt Cancer Center
Trevor D Hamilton, Amanda J Cannell, Minji Kim, Charles N Catton, Martin E Blackstein, Brendan C Dickson, Rebecca A Gladdy, Carol J Swallow
BACKGROUND: Local recurrence after resection of retroperitoneal sarcoma (RPS) is a common and difficult problem. Gross residual disease after incomplete resection is a particular challenge. The authors reviewed their experience with patients referred for management of recurrent or residual RPS. METHODS: Patients seen at the authors' center from 1996 to 2013 who had undergone resection at an outside institution were identified from a prospective database. Kaplan-Meier survival curves were generated and compared by log-rank analysis...
August 23, 2016: Annals of Surgical Oncology
Andrea S Porpiglia, Sanjay S Reddy, Jeffrey M Farma
Retroperitoneal sarcomas are rare tumors, representing only 15% of all sarcomas. The mainstay of therapy is surgical resection with negative margins. However, this is challenging because of the late presentation of many of these tumors and involvement with adjacent structures. Decisions on radiation therapy and chemotherapy should be made in a multidisciplinary setting at a tertiary referral center.
October 2016: Surgical Clinics of North America
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