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https://www.readbyqxmd.com/read/28298170/concussion-induces-hippocampal-circuitry-disruption-in-swine
#1
John A Wolf, Brian N Johnson, Victoria E Johnson, Mary E Putt, Kevin D Browne, Constance J Mietus, Daniel P Brown, Kathryn L Wofford, Douglas H Smith, M Sean Grady, Akiva S Cohen, D Kacy Cullen
Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI), however the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following TBI using a model of head rotational acceleration that closely replicates the biomechanics and neuropathology of closed-head TBI in humans. We examined neurophysiological changes using a novel ex vivo hippocampal slice paradigm with extracellular stimulation and recording in the dentate gyrus and CA1 occurring at 7 days following non-impact inertial TBI in swine...
March 16, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28296510/multidisciplinary-outpatient-treatment-in-patients-with-mild-traumatic-brain-injury-a-randomised-controlled-intervention-study
#2
Eirik Vikane, Torgeir Hellstrøm, Cecilie Røe, Erik Bautz-Holter, Jörg Aßmus, Jan Sture Skouen
OBJECTIVE: To evaluate the efficacy of a multidisciplinary outpatient follow-up programme compared to follow-up by a general practitioner for patients being at-risk or sick-listed with persistent post-concussion symptoms two months after a mild traumatic brain injury. DESIGN: Randomised controlled trial. PATIENTS: One hundred fifty-one patients, 16-56 years. METHODS: Multidisciplinary outpatient rehabilitation with individual contacts and a psycho-educational group intervention at two outpatient rehabilitation clinics compared to follow-up by a general practitioner after the multidisciplinary examination...
March 15, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28293983/trajectories-and-risk-factors-for-posttraumatic-stress-symptoms-following-pediatric-concussion
#3
Katherine Truss, Celia Godfrey, Michael Takagi, Franz Babl, Silvia Bressan, Stephen J C Hearps, Cathriona Clarke, Kevin Dunne, Vicki Anderson
A substantial minority of children experience posttraumatic stress symptoms (PTSS) following injury. Research indicates variation in the trajectory of PTSS following pediatric injury, but investigation of PTSS following concussion has assumed homogeneity. This study aimed to identify differential trajectories of PTSS following pediatric concussion and to investigate risk-factors, including acute post-concussive symptoms (PCS), associated with these trajectories. 120 children aged 8-18 years reported PTSS for 3 months following concussion diagnosis using the Child PTSD Symptom Scale, with a score of 16 or above indicating probable PTSD diagnosis...
March 15, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28292694/asb-clinical-biomechanics-award-winner-2016-assessment-of-gaze-stability-within-24-48hours-post-concussion
#4
Nicholas G Murray, Nathan R D'Amico, Douglas Powell, Megan E Mormile, Katelyn E Grimes, Barry A Munkasy, Russell K Gore, Rebecca J Reed-Jones
BACKGROUND: Approximately 90% of athletes with concussion experience a certain degree of visual system dysfunction immediately post-concussion. Of these abnormalities, gaze stability deficits are denoted as among the most common. Little research quantitatively explores these variables post-concussion. As such, the purpose of this study was to investigate and compare gaze stability between a control group of healthy non-injured athletes and a group of athletes with concussions 24-48hours post-injury...
March 6, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28285252/anxiety-sensitivity-mediates-gender-differences-in-post-concussive-symptoms-in-a-clinical-sample
#5
Brian J Albanese, Joseph W Boffa, Richard J Macatee, Norman B Schmidt
Traumatic brain injury (TBI) is both prevalent and potentially disabling. Extant literature has demonstrated women to report greater post-concussive symptoms (PCS) compared to men, highlighting the necessity of investigations into malleable, gender-linked risk factors for PCS that hold promise for reducing this gender disparity. Anxiety Sensitivity (AS) and Distress Tolerance (DT) are gender-linked risk factors that may be related to PCS. Despite a breadth of research supporting elevated AS and reduced DT in women, no study to date has investigated whether AS and DT mediate gender differences in PCS...
March 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28283595/astroglial-activation-and-altered-amyloid-metabolism-in-human-repetitive-concussion
#6
Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kina Höglund, Erik Portelius, David L Brody, Kaj Blennow, Henrik Zetterberg
OBJECTIVE: To determine whether postconcussion syndrome (PCS) due to repetitive concussive traumatic brain injury (rcTBI) is associated with CSF biomarker evidence of astroglial activation, amyloid deposition, and blood-brain barrier (BBB) impairment. METHODS: A total of 47 participants (28 professional athletes with PCS and 19 controls) were assessed with lumbar puncture (median 1.5 years, range 0.25-12 years after last concussion), standard MRI of the brain, and Rivermead Post-Concussion Symptoms Questionnaire (RPQ)...
March 10, 2017: Neurology
https://www.readbyqxmd.com/read/28268276/preliminary-results-of-residual-deficits-observed-in-athletes-with-concussion-history-combined-eeg-and-cognitive-study
#7
Tamanna T K Munia, Jeffrey L Gendreau, Ajay K Verma, Benjamin D Johnson, Mark Romanick, Kouhyar Tavakolian, Reza Fazel-Rezai
Assessment, treatment, and management of sport-related concussions are a widely recognized public health issue. Although several neuropsychological and motor assessment tools have been developed and implemented for sports teams at various levels and ages, the sensitivity of these tests has yet to be validated with more objective measures to make return-to-play (RTP) decisions more confidently. The present study sought to analyze the residual effect of concussions on a sample of adolescent athletes who sustained one or more previous concussions compared to those who had no concussion history...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262355/the-importance-of-a-neck-exam-in-sport-related-concussion-cervical-schwannoma-in-post-concussion-syndrome
#8
David M Langelier, Kathryn J Schneider, John Hurlbert, Chantel T Debert
OBJECTIVE: Few cases of cervical schwannoma have been reported following head trauma. The present case, involves a schwannoma of the C2 spinal nerve mimicking post-concussion symptoms following a sport-related concussion (SRC). DESIGN: Case study. SETTING: University of Calgary, Sport Medicine Clinic, Calgary, Alberta, Canada. RESULTS: We report a 28 year old, athlete who developed headache, dizziness, photophobia, and neck pain following a cycling accident...
January 17, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28259770/a-prospective-investigation-of-changes-in-the-sensorimotor-system-following-sports-concussion-an-exploratory-study
#9
Julie A Hides, Melinda M Franettovich Smith, M Dilani Mendis, Nigel A Smith, Andrew J Cooper, Julia Treleaven, Felix Leung, Andrew J Gardner, Paul McCrory, Nancy L Low Choy
BACKGROUND: Sports concussion is a risk for players involved in high impact, collision sports. Post-concussion, the majority of symptoms subside within 7-10 days, but can persist in 10-20% of athletes. Understanding the effects of sports concussion on sensorimotor systems could inform physiotherapy treatment. OBJECTIVE: To explore changes in sensorimotor function in the acute phase following sports concussion. DESIGN: Prospective cohort study...
February 24, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28250556/cascade-of-traumatic-brain-injury-a-correlational-study-of-cognition-postconcussion-symptoms-and-quality-of-life
#10
Rajakumari Pampa Reddy, Jamuna Rajeswaran, B Indira Devi, Thennarasu Kandavel
INTRODUCTION: Traumatic brain injury (TBI) constitutes a significant burden on health care resources in India. TBI is a dynamic process which involves damage to the brain thus leading to behavior cognitive and emotional consequences. AIM: To study the cognitive profile, post-concussion symptoms (PCS), quality of life (QOL), and their correlation. METHODS: A total of 60 patients with TBI were recruited and assessed for neuropsychological profile, PCS, and QOL, the correlation among the variables were analyzed...
January 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28228043/impact-of-exercise-on-clinical-symptom-report-and-neurocognition-after-concussion-in-children-and-adolescents
#11
Vicky Manikas, Franz E Babl, Stephen Hearps, Julian Dooley, Vicki Anderson
Recovery from concussion in childhood is poorly understood, despite its importance in decisions regarding return to normal activity. Resolution of post-concussive symptoms (PCS) is widely employed as a marker of recovery in clinical practice; however, it is unclear whether subtle impairments persist only to re-emerge in the context of increased physical or cognitive demands. This study aimed to examine the effect of strenuous exercise on clinical symptom report and neurocognition in children and adolescents after PCS resolution after concussion...
March 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28226433/preliminary-results-of-residual-deficits-observed-in-athletes-with-concussion-history-combined-eeg-and-cognitive-study
#12
Tamanna T K Munia, Jeffrey L Gendreau, Ajay K Verma, Benjamin D Johnson, Mark Romanick, Kouhyar Tavakolian, Reza Fazel-Rezai, Tamanna T K Munia, Jeffrey L Gendreau, Ajay K Verma, Benjamin D Johnson, Mark Romanick, Kouhyar Tavakolian, Reza Fazel-Rezai, Reza Fazel-Rezai, Jeffrey L Gendreau, Benjamin D Johnson, Tamanna T K Munia, Ajay K Verma, Kouhyar Tavakolian, Mark Romanick
Assessment, treatment, and management of sport-related concussions are a widely recognized public health issue. Although several neuropsychological and motor assessment tools have been developed and implemented for sports teams at various levels and ages, the sensitivity of these tests has yet to be validated with more objective measures to make return-to-play (RTP) decisions more confidently. The present study sought to analyze the residual effect of concussions on a sample of adolescent athletes who sustained one or more previous concussions compared to those who had no concussion history...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28211600/feasibility-of-early-physical-therapy-for-dizziness-after-a-sports-related-concussion-a-randomized-clinical-trial
#13
J C Reneker, A Hassen, R S Phillips, M C Moughiman, M Donaldson, J Moughiman
The purpose of this study was to (a) assess the feasibility of recruitment/retention of participants, protocol/resource management, and participant safety, and (b) estimate the size of the effect between the experimental and control groups. This was a feasibility study conducted as a prospective pilot double-blind randomized clinical trial. Subjects aged 10-23 years old with acute concussion and dizziness were enrolled from sports medicine centers. Forty-one participants were randomized into treatment and were seen for physical therapy beginning at 10 days post-concussion...
February 17, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28192036/using-acute-performance-on-a-comprehensive-neurocognitive-vestibular-and-ocular-motor-assessment-battery-to-predict-recovery-duration-after-sport-related-concussions
#14
Alicia M Sufrinko, Gregory F Marchetti, Paul E Cohen, R J Elbin, Valentina Re, Anthony P Kontos
BACKGROUND: A sport-related concussion (SRC) is a heterogeneous injury that requires a multifaceted and comprehensive approach for diagnosis and management, including symptom reports, vestibular/ocular motor assessments, and neurocognitive testing. PURPOSE: To determine which acute (eg, within 7 days) vestibular, ocular motor, neurocognitive, and symptom impairments predict the duration of recovery after an SRC. STUDY DESIGN: Cohort study (prognosis); Level of evidence, 2...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28188778/work-limitations-four-years-following-mild-traumatic-brain-injury-a-cohort-study
#15
Alice Theadom, Suzanne Barker-Collo, Kelly Jones, Michael Kahan, Braden Te Ao, Kathryn McPherson, Nicola Starkey, Valery Feigin
OBJECTIVE: To explore employment status, work limitations and productivity loss following mild traumatic brain injury (TBI). STUDY DESIGN: Inception cohort study over four years. SETTING: General community. PARTICIPANTS: 245 Adults (>16 years at the time of injury), who experienced a mild TBI and who were employed prior to their injury. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: Details of the injury, demographic information and pre-injury employment status were collected from medical records and self-report...
February 7, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28170134/mild-traumatic-brain-injury-is-something-missing-when-comparing-cognitive-rest-and-graduated-return-to-usual-activities-versus-usual-care
#16
Vaitsa Giannouli
I read with great interest the article by Varner et al.(1) which aims to determine in a simple, concise, and neat way if mild traumatic brain injury (MTBI) patients randomized to graduated return to usual activity discharge instructions have a decrease in their Post Concussion Symptom Score (PCSS) two weeks after MTBI, compared to patients who receive usual care MTBI discharge instructions. This article is protected by copyright. All rights reserved.
February 7, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28169147/single-task-and-dual-task-tandem-gait-test-performance-after-concussion
#17
David R Howell, Louis R Osternig, Li-Shan Chou
OBJECTIVES: To compare single-task and dual-task tandem gait test performance between athletes after concussion with controls on observer-timed, spatio-temporal, and center-of-mass (COM) balance control measurements. DESIGN: Ten participants (19.0±5.5years) were prospectively identified and completed a tandem gait test protocol within 72h of concussion and again 1 week, 2 weeks, 1 month, and 2 months post-injury. Seven uninjured controls (20.0±4.5years) completed the same protocol in similar time increments...
January 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28167303/psychological-and-lifestyle-factors-that-influence-the-serial%C3%A2-reporting-of-postconcussion-like-symptoms-in-a-nonconcussed-population
#18
Arun Prasad Balasundaram, Josie Athens, Anthony Gerard Schneiders, Paul McCrory, Stephen John Sullivan
BACKGROUND: Symptoms related to concussion are generally found to be nonspecific in nature, as they are also reported by nonconcussed individuals. What is currently not known is whether the symptoms vary over time, and whether they are also influenced by a multitude of factors. OBJECTIVE: The aim of this study was to investigate the potential influence of psychological, lifestyle, and situational factors on the change in postconcussion-like symptoms reported over 7 consecutive days in a cohort of normal individuals...
February 4, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28162097/is-age-associated-with-the-severity-of-post-mild-traumatic-brain-injury-symptoms
#19
Tina Hu, Cindy Hunt, Donna Ouchterlony
BACKGROUND: Mild traumatic brain injury (mTBI) is a significant public health concern. Research has shown that mTBI is associated with persistent physical, cognitive, and behavioural symptoms, leading to significant direct and indirect medical costs. Our objective was to determine if age impacts the type and severity of post-mTBI symptoms experienced. METHODS: Retrospective analysis of prospectively collected data at a level 1 tertiary care outpatient head injury clinic...
February 6, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28153668/prevalence-of-hearing-loss-and-tinnitus-in-iraq-and-afghanistan-veterans-a-chronic-effects-of-neurotrauma-consortium-study
#20
A A Swan, J T Nelson, B Swiger, C A Jaramillo, B C Eapen, M Packer, M J Pugh
The purpose of this study was to describe the prevalence of hearing loss and tinnitus in a cohort of Iraq and Afghanistan Veterans (IAV) with common post-deployment conditions, including traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), and other typical post-concussive conditions such as headaches and vertigo/dizziness. This retrospective observational study used data from the national Veterans Health Administration (VA) data repository from fiscal years 2001-2014. Veteran data was included if there were at least three years of VA care, with one or more years of care in 2007 or after...
January 31, 2017: Hearing Research
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