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https://www.readbyqxmd.com/read/29922224/neuroendocrine-abnormalities-following-traumatic-brain-injury-an-important-contributor-to-neuropsychiatric-sequelae
#1
REVIEW
Amir M Molaie, Jamie Maguire
Neuropsychiatric symptoms following traumatic brain injury (TBI) are common and contribute negatively to TBI outcomes by reducing overall quality of life. The development of neurobehavioral sequelae, such as concentration deficits, depression, anxiety, fatigue, and loss of emotional well-being has historically been attributed to an ambiguous "post-concussive syndrome," considered secondary to frank structural injury and axonal damage. However, recent research suggests that neuroendocrine dysfunction, specifically hypopituitarism, plays an important role in the etiology of these symptoms...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29913077/higher-exosomal-tau-amyloid-beta-42-and-il-10-are-associated-with-mild-tbis-and-chronic-symptoms-in-military-personnel
#2
Jessica Gill, Maja Mustapic, Ramon Diaz-Arrastia, Rael Lange, Seema Gulyani, Tom Diehl, Vida Motamedi, Nicole Osier, Robert A Stern, Dimitrios Kapogiannis
OBJECTIVE: Identify biomarkers in peripheral blood that relate to chronic post-concussive and behavioural symptoms following traumatic brain injuries (TBIs) to ultimately improve clinical management. RESEARCH DESIGN: We compared military personnel with mild TBIs (mTBIs) (n = 42) to those without TBIs (n = 22) in concentrations of tau, amyloid-beta (Aβ42) and cytokines (tumour necrosis factor alpha (TNFα, interleukin (IL)-6 and -10) in neuronal-derived exosomes from the peripheral blood...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29911576/symptoms-disabilities-and-life-satisfaction-five-years-after-whiplash-injuries
#3
Johan Styrke, Peter Sojka, Ulf Björnstig, Britt-Marie Stålnacke
Background Chronic whiplash-associated disorders (WADs) are often associated with social functioning problems and decreased ability to perform previous activities. This may lead to decreased life satisfaction, which is insufficiently studied in the context of whiplash injuries. Symptoms included in chronic WAD are similar to symptoms frequently reported by persons who have sustained mild traumatic brain injury (MTBI)/concussion. In cases of MTBI, the severity and number of symptoms have been suggested to have a diagnostic value...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29902070/determining-sensitivity-and-specificity-of-the-sport-concussion-assessment-tool-3-scat3-components-in-university-athletes
#4
Rachel I Downey, Michael G Hutchison, Paul Comper
OBJECTIVE: To examine the clinical utility of the Sport Concussion Assessment Tool-3 (SCAT3) in university athletes with concussion in the absence and presence of baseline data over time. METHODS: Athletes with concussion (n = 23) and uninjured controls (n = 22) were prospectively evaluated at three time-points (baseline, 3-5 days, 3 weeks post-injury) with the SCAT3 components: (1) Post-Concussion Symptom Scale (PCSS); (2) Standardized Assessment of Concussion (SAC); and (3) modified Balance Error Scoring System (m-BESS)...
June 14, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29897861/visual-and-vestibular-involvement-in-postural-deficits-following-concussion
#5
Madeleine K Nowak
Postural assessment is often recommended as a component of post-concussion examination; however, a reliable, objective approach to identify and monitor the recovery of postural deficits is still needed. Degani et al. (2017) suggest that effects of concussion on postural control can be identified at the group level through spatio-temporal, frequency, and dynamic characteristics of balance. In contrast, Wright et al. (2017) propose additional vestibular and oculomotor assessments to identify processing deficits that impair balance following concussion in individuals...
June 13, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29894921/emergency-room-intervention-to-prevent-post-concussion-like-symptoms-and-post-traumatic-stress-disorder-a-pilot-randomized-controlled-study-of-a-brief-eye-movement-desensitization-and-reprocessing-intervention-versus-reassurance-or-usual-care
#6
Cédric Gil-Jardiné, Grégoire Evrard, Samantha Al Joboory, Juliane Tortes Saint Jammes, Françoise Masson, Régis Ribéreau-Gayon, Michel Galinski, Louis-Rachid Salmi, Philippe Revel, Cyril Alexandre Régis, Guillaume Valdenaire, Emmanuel Lagarde
Up to 20% of patients presenting at an emergency room (ER) after a stressful event will for several months suffer from very diverse long-lasting symptoms and a potentially significant decline in quality of life, often described as post concussion-like symptoms (PCLS). The objectives of our randomized open-label single-center study were to assess the feasibility of psychologist-led interventions in the context of the ER and to compare the effect of eye movement desensitization and reprocessing (EMDR) with reassurance and usual care...
May 26, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29889559/higher-exosomal-phosphorylated-tau-and-total-tau-among-veterans-with-combat-related-repetitive-chronic-mild-traumatic-brain-injury
#7
Kimbra Kenney, Bao-Xi Qu, Chen Lai, Christina Devoto, Vida Motamedi, William C Walker, Harvey S Levin, Tracy Nolen, Elisabeth A Wilde, Ramon Diaz-Arrastia, Jessica Gill
OBJECTIVE: The objective of the study is to measure plasma and exosomal levels of tau, phosphorylated tau (p-tau), and amyloid beta (Aβ) in Veterans with historical mild traumatic brain injury (mTBI) and chronic neuropsychological symptoms. METHODS: Tau, p-tau, Aβ40, and Aβ42 were measured by ultrasensitive immunoassay in plasma and exosomes from 195 Veterans enrolled in the Chronic Effects of Neurotrauma Consortium Multicenter Observational Study. Protein biomarkers were compared among groups with and without mTBI with loss of consciousness (LOC) or post-traumatic amnesia (PTA), and also in those with and without repetitive (≥3) mTBI (rTBI) compared to those with 0 (TBI-neg) and 1-2 mTBI...
June 11, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29888387/evidence-brief-hyperbaric-oxygen-therapy-hbot-for-traumatic-brain-injury-and-or-post-traumatic-stress-disorder
#8
EDITORIAL
Michael H Bennett
This report is a product of the VA Evidence-based Synthesis Program. The purpose is to provide "timely and accurate syntheses of targeted healthcare topics …. to improve the health and healthcare of Veterans". The authors have made a comprehensive search and analysis of the literature and make recommendations to assist clinicians in dealing with veterans suffering from either traumatic brain injury (TBI) or post-traumatic stress disorder (PTSD). The report is timely and of great potential impact given the vigorous and lengthy debate among hyperbaric physicians and lay people determined to find an answer for the large numbers of veterans deeply affected with some combination of PTSD and post-concussion dysfunction...
June 30, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29888305/evidence-for-altered-brain-reactivity-to-norepinephrine-in-veterans-with-a-history-of-traumatic-stress
#9
Rebecca C Hendrickson, Murray A Raskind, Steven P Millard, Carl Sikkema, Garth E Terry, Kathleen F Pagulayan, Ge Li, Elaine R Peskind
Background: Increases in the quantity or impact of noradrenergic signaling have been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). This increased signaling may result from increased norepinephrine (NE) release, from altered brain responses to NE, or from a combination of both factors. Here, we tested the hypothesis that Veterans reporting a history of trauma exposure would show an increased association between brain NE and mental health symptoms commonly observed after trauma, as compared to Veterans who did not report a history of trauma exposure, consistent with the possibility of increased brain reactivity to NE after traumatic stress...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29877168/association-between-ondansetron-use-and-symptom-persistence-in-children-with-concussions-a-5p-substudy
#10
Jocelyn Gravel, Kathy Boutis, Ken Tang, Miriam H Beauchamp, Stephen B Freedman, Alexander Sasha Dubrovsky, Isabelle Gagnon, Frank Momoli, Roger Zemek
CLINICIAN'S CAPSULE What is known about the topic? Most children who sustain a concussion suffer from post-concussion symptoms for many weeks following the accident. What did this study ask? Is there an association between ondansetron administration and the presence of persistent post-concussion symptoms at 1 week and 1 month in children? What did this study find? This observational study found that the use of ondansetron among children presenting to the emergency department with an acute concussion was associated with a higher risk of persistent symptoms at 1 month...
June 7, 2018: CJEM
https://www.readbyqxmd.com/read/29874472/the-incidence-of-anosmia-after-traumatic-brain-injury-the-shefbit-cohort
#11
Rajiv Singh, Thomas Humphries, Suzanne Mason, Fiona Lecky, Jeremy Dawson, Saurabh Sinha
BACKGROUND: While anosmia is common after Traumatic Brain Injury(TBI) (prevalence 4%-68%),studies differ in the associations found with other variables. AIMS: To assess the incidence of anosmia within a large, mixed TBI cohort and examine relationships with other injury or demographic features, including depression and global outcome(GOSE). DESIGN, SUBJECTS AND SETTING: 774 consecutive TBI admissions over 2 years, assessed within a specialist neurorehabilitation clinic...
June 6, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29865932/detection-of-symptom-over-reporting-on-the-neurobehavioral-symptom-inventory-in-oef-oif-ond-veterans-with-history-of-mild-tbi
#12
Anjuli S Bodapati, Hannah L Combs, Nicholas J Pastorek, Brian Miller, Maya Troyanskaya, Jennifer Romesser, Anita Sim, John Linck
OBJECTIVE: As part of routine care at Veterans Affairs facilities, veterans with a service-related traumatic brain injury (TBI) are administered a self-report post-concussive symptom measure, the Neurobehavioral Symptom Inventory (NSI). Interpreting the NSI can be problematic given that over-reporting on self-report measures is often found in both civilian and military patient populations. This study investigates embedded scales on the NSI that identify possible and probable symptom exaggeration...
June 5, 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29863894/concordance-of-common-data-elements-for-assessment-of-subjective-cognitive-complaints-after-mild-traumatic-brain-injury-a-track-tbi-pilot-study
#13
Laura B Ngwenya, Raquel C Gardner, John K Yue, John F Burke, Adam R Ferguson, Michael C Huang, Ethan A Winkler, Romain Pirracchio, Gabriela G Satris, Esther L Yuh, Pratik Mukherjee, Alex B Valadka, David O Okonkwo, Geoffrey T Manley
OBJECTIVE: To determine characteristics and concordance of subjective cognitive complaints (SCCs) 6 months following mild-traumatic brain injury (mTBI) as assessed by two different TBI common data elements (CDEs). RESEARCH DESIGN: The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot Study was a prospective observational study that utilized the NIH TBI CDEs, Version 1.0. We examined variables associated with SCC, performance on objective cognitive tests (Wechsler Adult Intelligence Scale, California Verbal Learning Test, and Trail Making Tests A and B), and agreement on self-report of SCCs as assessed by the acute concussion evaluation (ACE) versus the Rivermead Post Concussion Symptoms Questionnaire (RPQ)...
June 4, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29851513/reduced-dual-task-gait-speed-is-associated-with-visual-go-no-go-brain-network-activation-in-children-and-adolescents-with-concussion
#14
David R Howell, William P Meehan, Kim D Barber Foss, Amit Reches, Michal Weiss, Gregory D Myer
OBJECTIVE: To investigate the association between dual-task gait performance and brain network activation (BNA) using an electroencephalography (EEG)-based Go/No-Go paradigm among children and adolescents with concussion. METHODS: Participants with a concussion completed a visual Go/No-Go task with collection of electroencephalogram brain activity. Data were treated with BNA analysis, which involves an algorithmic approach to EEG-ERP activation quantification. Participants also completed a dual-task gait assessment...
May 31, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29850866/the-minnesota-multiphasic-personality-inventory-2-rf-in-treatment-seeking-veterans-with-history-of-mild-traumatic-brain-injury
#15
S M Jurick, L D Crocker, A V Keller, S N Hoffman, J Bomyea, M W Jacobson, A J Jak
Objective: This study examined the Minnesota Multiphasic Personality Inventory-Second Edition-Restructured Form (MMPI-2-RF) to better understand symptom presentation in a sample of treatment-seeking Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans with self-reported history of mild traumatic brain injury (mTBI). Method: Participants underwent a comprehensive clinical neuropsychological battery including performance and symptom validity measures and self-report measures of depressive, posttraumatic, and post-concussive symptomatology...
May 30, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29846269/an-exploration-of-the-impact-of-initial-timing-of-physical-therapy-on-safety-and-outcomes-after-concussion-in-adolescents
#16
Anne Lennon, Jason A Hugentobler, Mary Claire Sroka, Katharine S Nissen, Brad G Kurowski, Isabelle Gagnon, Catherine C Quatman-Yates
BACKGROUND AND PURPOSE: Physical therapy (PT) is a management strategy increasingly recognized to facilitate recovery after concussion. The purpose of this study was to investigate the safety and outcomes of multimodal impairment-based PT at varying time points after injury in youth diagnosed with concussion. METHODS: Data were extracted retrospectively from medical records for patients who received PT for concussion-related impairments. Patient records were categorized into 3 cohorts on the basis of the timing of PT implementation: 0-20 days following injury (early intervention), 21 to 41 days following injury (middle intervention), and 42 or more days following injury (late intervention)...
May 24, 2018: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/29781392/adolescent-athletes-with-learning-disability-display-atypical-maturational-trajectories-on-concussion-baseline-testing-implications-based-on-a-finnish-sample
#17
Kati Peltonen, Matti Vartiainen, Tiina Laitala-Leinonen, Sanna Koskinen, Teemu Luoto, Jon Pertab, Laura Hokkanen
Previous research has reported lower cognitive test scores on baseline testing in athletes reporting multiple previous concussions or a history of learning disability (LD). Age also has an important influence on cognitive performance. While these factors have been considered individually in previous studies, the present study is the first to explore the interaction of age, self-reported LD, and history of concussion on baseline Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT®) in a nationwide study of adolescent athletes...
May 21, 2018: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/29737227/post-concussion-driving-behaviors-and-opinions-a-survey-of-collegiate-student-athletes
#18
Julianne D Schmidt, Robert C Lynall, Landon Bryce Lempke, Michelle L Weber, Hannes Devos
Post-concussion driving restrictions are eminent, but we lack understanding of current behaviors and opinions about driving following concussion among populations at risk of concussion. We aimed to describe post-concussion driving behaviors and opinions among collegiate student-athletes. Student-athletes completed a survey (response rate=45.3%, 223/492) regarding their post-concussion driving behaviors and opinions. Response frequencies and percentages are presented. Student-athletes self-reported a total of 169 lifetime concussions (0...
May 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29734566/hyperbaric-oxygen-for-post-concussive-symptoms-in-united-states-military-service-members-a-randomized-clinical-trial
#19
Lindell K Weaver, Steffanie H Wilson, Anne S Lindblad, Susan Churchill, Kayla Deru, Robert C Price, Chris S Williams, William W Orrison, James M Walker, Anna Meehan, Susan Mirow
Background: In prior military randomized trials, participants with persistent symptoms after mild traumatic brain injury (TBI) reported improvement regardless of receiving hyperbaric oxygen (HBO₂) or sham intervention. This study's objectives were to identify outcomes for future efficacy trials and describe changes by intervention. Methods: This Phase II, randomized, double-blind, sham-controlled trial enrolled military personnel with mild TBI and persistent post-concussive symptoms...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29729683/effects-of-repeated-concussions-and-sex-on-early-processing-of-emotional-facial-expressions-as-revealed-by-electrophysiology
#20
Frédérike Carrier-Toutant, Samuel Guay, Christelle Beaulieu, Édith Léveillé, Alexandre Turcotte-Giroux, Samaël D Papineau, Benoit Brisson, Fabien D'Hondt, Louis De Beaumont
OBJECTIVES: Concussions affect the processing of emotional stimuli. This study aimed to investigate how sex interacts with concussion effects on early event-related brain potentials (ERP) measures (P1, N1) of emotional facial expressions (EFE) processing in asymptomatic, multi-concussion athletes during an EFE identification task. METHODS: Forty control athletes (20 females and 20 males) and 43 multi-concussed athletes (22 females and 21 males), recruited more than 3 months after their last concussion, were tested...
May 6, 2018: Journal of the International Neuropsychological Society: JINS
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