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https://www.readbyqxmd.com/read/28822327/improvements-in-balance-control-in-individuals-with-pcs-detected-following-vestibular-training-a-case-study
#1
Alyssa Prangley, Mathew Aggerholm, Michael Cinelli
Concussed individuals have been found to experience balance deficits in the anterior-posterior (AP) direction as indicated by greater Center of Pressure (COP) displacement and velocity. One possible reason for this change in balance control could be due to damage to the lateral vestibulospinal tract which sends signals to control posterior muscles, specifically ankle extensors leading to compensatory torques about the ankle. The purpose of the study was to quantify balance assessments in individuals experiencing persistent post-concussion symptoms (PCS) to determine balance control changes following a vestibular training intervention...
August 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28818697/kinematic-differences-during-a-jump-cut-maneuver-between-individuals-with-and-without-a-concussion-history
#2
Andrew Lapointe, Luis Nolasco, Aniela Sosnowski, Eva Andrews, Douglas N Martini, Riann M Palmieri-Smith, Deanna H Gates, Steven P Broglio
Recent evidence suggests that athletes are at a higher risk of lower-body injuries in the months and years following a concussion. However, little is known about how people modify their movements post-concussion. This study examined kinematics during a jump cut motion in young adults with a concussion history (n=9; 4 males, 5 females; 3.1years' post-injury) and 10 controls (6 males, 4 females). Peak center of mass and peak knee angles during the landing phase of a jump-cut maneuver were evaluated. Participants with a concussion history demonstrated decreased knee varus (left: Mconc=-0...
August 14, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28817065/evaluation-and-treatment-of-mild-traumatic-brain-injury-the-role-of-neuropsychology
#3
REVIEW
Carolyn Prince, Maya E Bruhns
Awareness of mild traumatic brain injury (mTBI) and persisting post-concussive syndrome (PCS) has increased substantially in the past few decades, with a corresponding increase in research on diagnosis, management, and treatment of patients with mTBI. The purpose of this article is to provide a narrative review of the current literature on behavioral assessment and management of patients presenting with mTBI/PCS, and to detail the potential role of neuropsychologists and rehabilitation psychologists in interdisciplinary care for this population during the acute, subacute, and chronic phases of recovery...
August 17, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28816563/highlighting-the-differences-in-post-traumatic-symptoms-between-patients-with-complicated-and-uncomplicated-mild-traumatic-brain-injury-and-injured-controls
#4
J Julien, S Tinawi, K Anderson, L C Frenette, H Audrit, M C Ferland, M Feyz, E De Guise
OBJECTIVE: The goal of the current study is to explore the difference in acute post-concussive symptoms (PCS), headaches, sleep and mood complaints between groups of patients with complicated and uncomplicated mild traumatic brain injuries (mTBIs) and a comparable group of injured controls. Interactions among the following four factors were studied: presence of (1) PCS; (2) headaches; (3) sleep disorders; and (4) psychological status. METHODS: A total of 198 patients, followed at the outpatient mTBI clinic of the MUHC-MGH, completed questionnaires and a brief neurological assessment two weeks post-trauma...
August 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28816519/the-effects-of-exercise-on-a-choice-reaction-time-task-in-individuals-with-post-concussion-syndrome
#5
Stephanie A Ramautar, Alyssa A Prangley, Michael E Cinelli
PURPOSE: To assess cognitive performance differences pre- and post-exercise in individuals without concussion (non-concussed, NC) and individuals with post-concussion syndrome (PCS). METHODS: A total of 30 participants completed a choice reaction time (CRT) task in the form of an iPad application, measuring each individual's decision-making capabilities, while wearing a head-mounted eye tracker system. Participants completed four blocks of testing; the time interval between the first two blocks of trials and the last two blocks of trials was 10 minutes...
August 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28812290/a-preliminary-report-of-cerebral-white-matter-microstructural-changes-associated-with-adolescent-sports-concussion-acutely-and-subacutely-using-diffusion-tensor-imaging
#6
Trevor Wu, Tricia L Merkley, Elisabeth A Wilde, Amanda Barnes, Xiaoqi Li, Zili David Chu, Stephen R McCauley, Jill V Hunter, Harvey S Levin
Diffusion tensor imaging (DTI) has demonstrated its utility in detecting microscopic post-concussion cerebral white matter structural changes, which are not routinely evident on conventional neuroimaging modalities. In this study, we compared 10 adolescents with sports concussion (SC) to 12 orthopedically-injured (OI) individuals within 96 h and three months post injury to 12 typically-developing (TD) participants using DTI and volumetric analyses. In terms of volume, no group differences were noted between SC, OI and TD groups at both 96 h and three months post concussion...
August 15, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28809606/a-comparative-meta-analysis-of-the-effects-of-concussion-on-a-computerized-neurocognitive-test-and-self-reported-symptoms
#7
Bara Alsalaheen, Kayla Stockdale, Dana Pechumer, Steven P Broglio, Gregory F Marchetti
CONTEXT:   Meta-analyses examining construct-specific cognitive impairment concurrently with self-reported symptoms postconcussion are sparse. OBJECTIVE:   To review the literature on the effects of concussion on construct-specific neurocognitive declines and to compare them with self-reported symptoms before 1 week and between 1 and 3 weeks postconcussion. DATA SOURCES:   Relevant studies in PubMed, CINAHL, and PsycINFO published from January 1, 1999 through November 30, 2015...
August 15, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28797606/plasma-creatine-kinase-b-correlates-with-injury-severity-and-symptoms-in-professional-boxers
#8
Joseph Kilianski, Sophie Peeters, Jeff Debad, Joseph Mohmed, Steven E Wolf, Joseph P Minei, Ramon Diaz-Arrastia, Joshua W Gatson
INTRODUCTION: Each year in the United States, approximately 1.7 million people sustain a traumatic brain injury (TBI). Of these TBI events, about 75 percent are characterized as being mild brain injuries. Immediately following TBI, a secondary brain damage persists for hours, days, and even months. Previously, detection of neuronal and glial biomarkers have proven to be useful to predict neurological outcomes. Here, we hypothesized that creatine kinase, brain (CKBB) is a sensitive biomarker for acute secondary brain injury in professional boxers...
August 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28771032/reliability-of-computerized-neurocognitive-tests-for-concussion-assessment-a-meta-analysis
#9
James L Farnsworth, Lucas Dargo, Brian G Ragan, Minsoo Kang
OBJECTIVE:   Although widely used, computerized neurocognitive tests (CNTs) have been criticized because of low reliability and poor sensitivity. A systematic review was published summarizing the reliability of Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) scores; however, this was limited to a single CNT. Expansion of the previous review to include additional CNTs and a meta-analysis is needed. Therefore, our purpose was to analyze reliability data for CNTs using meta-analysis and examine moderating factors that may influence reliability...
August 3, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28769086/intergenerational-transmission-of-paternal-epigenetic-marks-mechanisms-influencing-susceptibility-to-post-concussion-symptomology-in-a-rodent-model
#10
Harleen Hehar, Irene Ma, Richelle Mychasiuk
Epigenetic transmission of phenotypic variance has been linked to paternal experiences prior to conception and during perinatal development. Previous reports indicate that paternal experiences increase phenotypic heterogeneity and may contribute to offspring susceptibility to post-concussive symptomology. This study sought to determine if epigenetic tags, specifically DNA methylation of promoter regions, are transmitted from rodent fathers to their sons. Using MethyLight, promoter methylation of specific genes involved in recovery from concussion and brain plasticity were analyzed in sperm and brain tissue...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28731886/collegiate-student-athletes-with-history-of-adhd-or-academic-difficulties-are-more-likely-to-produce-an-invalid-protocol-on-baseline-impact-testing
#11
Lisa Manderino, John Gunstad
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) and other academically-relevant diagnoses have been suggested as modifiers of neurocognitive testing in sport-related concussion, such as Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). These preexisting conditions may suppress ImPACT scores to the extent that they are indistinguishable from low scores because of poor effort. The present study hypothesized that student athletes with history of ADHD or academic difficulties produce lower ImPACT composite scores and are more likely to produce invalid protocols than those without such conditions...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28728465/evaluating-the-test-retest-reliability-of-symptom-indices-associated-with-the-impact-post-concussion-symptom-scale-pcss
#12
Victoria C Merritt, Megan L Bradson, Jessica E Meyer, Peter A Arnett
OBJECTIVE: The Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) is a commonly used tool in sports concussion assessment. While test-retest reliabilities have been established for the ImPACT cognitive composites, few studies have evaluated the psychometric properties of the ImPACT's Post-Concussion Symptom Scale (PCSS). The purpose of this study was to establish the test-retest reliability of symptom indices associated with the PCSS. PARTICIPANTS AND METHODS: Participants included 38 undergraduate students (50...
July 20, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28693815/comorbid-mild-traumatic-brain-injury-increases-pain-symptoms-in-patients-suffering-from-an-isolated-limb-fracture
#13
Marianne Jodoin, Dominique M Rouleau, Nadia Gosselin, Benoit Benoit, Stéphane Leduc, Yves Laflamme, Camille Larson-Dupuis, Louis De Beaumont
OBJECTIVES: This study seeks to evaluate the effects of a mild traumatic brain injury (mTBI) on pain in patients with an isolated limb fracture (ILF) when compared to a matched cohort group with no mTBI (control group). PATIENTS AND METHODS: All subjects included in this observational study suffered from an ILF. Groups were matched according to the type of injury, sex, age, and time since the accident. Main outcome measurements were: Standardized semi-structured interviews at follow-up of a Level I Trauma Center, and a questionnaire on fracture-related pain symptoms...
July 1, 2017: Injury
https://www.readbyqxmd.com/read/28693073/-resting-state-fmri-study-of-emotional-network-in-patients-with-postconcussion-syndrome
#14
X Zhang, R B Qian, X M Fu, B Lin, D Zhang, C S Xia, X P Wei, C S Niu, Y H Wang
Objective: To discuss functional connectivity changes in the emotional network of patients with post-concussion syndrome (PCS) and their clinical significance by resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Twenty-seven patients with PCS were recruited from the Department of Neurosurgery of Anhui provincial hospital affiliated to Anhui medical university from October 2015 to April 2016, and 27 healthy subjects were recruited as the controls. The Hamilton Anxiety Scale (HAMA) and The Hamilton Depression Scale (HAMD) were used to evaluate the emotional state of two groups of subjects...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28685977/the-post-therapeutic-effect-of-rapamycin-in-mild-traumatic-brain-injured-rats-ensuing-in-the-upregulation-of-autophagy-and-mitophagy
#15
Changxing Wang, Zhiying Hu, Yang Zou, Mingjun Xiang, Yuting Jiang, Benson O A Botchway, Xue Huo, Xiaoxue Du, Marong Fang
Mild traumatic brain injury (mTBI), common in juveniles, has been reported to be caused by sports-related concussion. Many young children may suffer from post-concussion syndrome. mTBI, in early stages of life, could play a part in neuron apoptosis and degeneration, cognitive and motor coordination impairment, as well as dementia. Our study was aimed at further investigating the post-therapeutic efficacy of rapamycin in the recuperation of mTBI while at the same time investigating the metamorphosis in both autophagy and mitophagy in mTBI...
September 2017: Cell Biology International
https://www.readbyqxmd.com/read/28680725/glioblastoma-multiforme-presenting-with-an-open-ring-pattern-of-enhancement-on-mr-imaging
#16
Merritt D Kinon, Aleka Scoco, Joaquim M Farinhas, Andrew Kobets, Karen M Weidenheim, Reza Yassari, Patrick A Lasala, Jerome Graber
BACKGROUND: Intracerebral ring enhancing lesions can be the presentation of a variety of pathologies, including neoplasia, inflammation, and autoimmune demyelination. Use of a precise diagnostic algorithm is imperative in correctly treating these lesions and minimizing potential adverse treatment effects. CASE DESCRIPTION: A 55-year-old patient presented to the hospital with complaints of a post-concussive syndrome and a non-focal neurologic exam. Imaging revealed a lesion with an open ring enhancement pattern, minimal surrounding vasogenic edema, and minimal mass effect...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28678608/increased-symptom-reporting-in-young-athletes-based-on-history-of-previous-concussions
#17
Rosemarie Scolaro Moser, Philip Schatz
Research documents increased symptoms in adolescents with a history of two or more concussions. This study examined baseline evaluations of 2,526 younger athletes, ages 10 to 14. Between-groups analyses examined Post Concussion Symptom Scale symptoms by concussion history group (None, One, Two+) and clusters of Physical, Cognitive, Emotional, and Sleep symptoms. Healthy younger athletes with a concussion history reported greater physical, emotional, and sleep-related symptoms than those with no history of concussion, with a greater endorsement in physical/sleep symptom clusters...
July 5, 2017: Developmental Neuropsychology
https://www.readbyqxmd.com/read/28676987/white-matter-abnormalities-in-mild-traumatic-brain-injury-with-and-without-post-traumatic-stress-disorder-a-subject-specific-diffusion-tensor-imaging-study
#18
Christian Lepage, Amicie de Pierrefeu, Inga K Koerte, Michael J Coleman, Ofer Pasternak, Gerald Grant, Christine E Marx, Rajendra A Morey, Laura A Flashman, Mark S George, Thomas W McAllister, Norberto Andaluz, Lori Shutter, Raul Coimbra, Ross D Zafonte, Murray B Stein, Martha E Shenton, Sylvain Bouix
Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using conventional neuroimaging tools, despite the fact that diffuse axonal injuries are the most common injury. Diffusion tensor imaging (DTI) is sensitive to diffuse axonal injuries and is thus more likely to detect mTBIs, especially when analyses account for the inter-individual variability of these injuries...
July 5, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28665173/serial-assessment-of-gray-matter-abnormalities-after-sport-related-concussion
#19
Lezlie Y España, Ryan M Lee, Josef M Ling, Andreas Jeromin, Andrew R Mayer, Timothy B Meier
There is an urgent need to characterize the acute physiological effects of sport-related concussion (SRC). We investigated the effects of SRC on gray matter structure and diffusion metrics in collegiate athletes at 1.64 (T1; n = 33), 8.33 (T2; n = 30), and 32.15 days (T3; n = 36) post-concussion, with healthy collegiate contact-sport athletes serving as controls (HA; n = 46). Plasma levels of glial fibrillary acidic protein (GFAP) were assessed in a subset of athletes. We hypothesized that acute SRC would be associated with increased fractional anisotropy (FA), decreased mean diffusivity (MD), and increased GFAP relative to noninjured HA, without acute differences in gray matter volume or cortical thickness...
August 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28664033/decreased-susceptibility-of-major-veins-in-mild-traumatic-brain-injury-is-correlated-with-post-concussive-symptoms-a-quantitative-susceptibility-mapping-study
#20
Chao Chai, Rui Guo, Chao Zuo, Linlin Fan, Saifeng Liu, Tianyi Qian, E Mark Haacke, Shuang Xia, Wen Shen
Cerebral venous oxygen saturation (SvO2) is an important biomarker of brain function. In this study, we aimed to explore the relative changes of regional cerebral SvO2 among axonal injury (AI) patients, non-AI patients and healthy controls (HCs) using quantitative susceptibility mapping (QSM). 48 patients and 32 HCs were enrolled. The patients were divided into two groups depending on the imaging based evidence of AI. QSM was used to measure the susceptibility of major cerebral veins. Nonparametric testing was performed for susceptibility differences among the non-AI patient group, AI patient group and healthy control group...
2017: NeuroImage: Clinical
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