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https://www.readbyqxmd.com/read/28731886/collegiate-student-athletes-with-history-of-adhd-or-academic-difficulties-are-more-likely-to-produce-an-invalid-protocol-on-baseline-impact-testing
#1
Lisa Manderino, John Gunstad
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) and other academically-relevant diagnoses have been suggested as modifiers of neurocognitive testing in sport-related concussion, such as Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT). These preexisting conditions may suppress ImPACT scores to the extent that they are indistinguishable from low scores because of poor effort. The present study hypothesized that student athletes with history of ADHD or academic difficulties produce lower ImPACT composite scores and are more likely to produce invalid protocols than those without such conditions...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28728465/evaluating-the-test-retest-reliability-of-symptom-indices-associated-with-the-impact-post-concussion-symptom-scale-pcss
#2
Victoria C Merritt, Megan L Bradson, Jessica E Meyer, Peter A Arnett
OBJECTIVE: The Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) is a commonly used tool in sports concussion assessment. While test-retest reliabilities have been established for the ImPACT cognitive composites, few studies have evaluated the psychometric properties of the ImPACT's Post-Concussion Symptom Scale (PCSS). The purpose of this study was to establish the test-retest reliability of symptom indices associated with the PCSS. PARTICIPANTS AND METHODS: Participants included 38 undergraduate students (50...
July 20, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28693815/comorbid-mild-traumatic-brain-injury-increases-pain-symptoms-in-patients-suffering-from-an-isolated-limb-fracture
#3
Marianne Jodoin, Dominique M Rouleau, Nadia Gosselin, Benoit Benoit, Stéphane Leduc, Yves Laflamme, Camille Larson-Dupuis, Louis De Beaumont
OBJECTIVES: This study seeks to evaluate the effects of a mild traumatic brain injury (mTBI) on pain in patients with an isolated limb fracture (ILF) when compared to a matched cohort group with no mTBI (control group). PATIENTS AND METHODS: All subjects included in this observational study suffered from an ILF. Groups were matched according to the type of injury, sex, age, and time since the accident. Main outcome measurements were: Standardized semi-structured interviews at follow-up of a Level I Trauma Center, and a questionnaire on fracture-related pain symptoms...
July 1, 2017: Injury
https://www.readbyqxmd.com/read/28693073/-resting-state-fmri-study-of-emotional-network-in-patients-with-postconcussion-syndrome
#4
X Zhang, R B Qian, X M Fu, B Lin, D Zhang, C S Xia, X P Wei, C S Niu, Y H Wang
Objective: To discuss functional connectivity changes in the emotional network of patients with post-concussion syndrome (PCS) and their clinical significance by resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Twenty-seven patients with PCS were recruited from the Department of Neurosurgery of Anhui provincial hospital affiliated to Anhui medical university from October 2015 to April 2016, and 27 healthy subjects were recruited as the controls. The Hamilton Anxiety Scale (HAMA) and The Hamilton Depression Scale (HAMD) were used to evaluate the emotional state of two groups of subjects...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28685977/the-post-therapeutic-effect-of-rapamycin-in-mild-traumatic-brain-injured-rats-ensuing-in-the-upregulation-of-autophagy-and-mitophagy
#5
Changxing Wang, Zhiying Hu, Yang Zou, Mingjun Xiang, Yuting Jiang, Benson O A Botchway, Xue Huo, Xiaoxue Du, Marong Fang
Mild traumatic brain injury (mTBI), common in juveniles, has been reported to be caused by sports-related concussion. Many young children may suffer from post-concussion syndrome. mTBI, in early stages of life, could play a part in neuron apoptosis and degeneration, cognitive and motor coordination impairment, as well as dementia. Our study was aimed at further investigating the post therapeutic efficacy of rapamycin in the recuperation of mTBI whiles at the same time investigating the metamorphosis in both autophagy and mitophagy in mTBI...
July 7, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28680725/glioblastoma-multiforme-presenting-with-an-open-ring-pattern-of-enhancement-on-mr-imaging
#6
Merritt D Kinon, Aleka Scoco, Joaquim M Farinhas, Andrew Kobets, Karen M Weidenheim, Reza Yassari, Patrick A Lasala, Jerome Graber
BACKGROUND: Intracerebral ring enhancing lesions can be the presentation of a variety of pathologies, including neoplasia, inflammation, and autoimmune demyelination. Use of a precise diagnostic algorithm is imperative in correctly treating these lesions and minimizing potential adverse treatment effects. CASE DESCRIPTION: A 55-year-old patient presented to the hospital with complaints of a post-concussive syndrome and a non-focal neurologic exam. Imaging revealed a lesion with an open ring enhancement pattern, minimal surrounding vasogenic edema, and minimal mass effect...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28678608/increased-symptom-reporting-in-young-athletes-based-on-history-of-previous-concussions
#7
Rosemarie Scolaro Moser, Philip Schatz
Research documents increased symptoms in adolescents with a history of two or more concussions. This study examined baseline evaluations of 2,526 younger athletes, ages 10 to 14. Between-groups analyses examined Post Concussion Symptom Scale symptoms by concussion history group (None, One, Two+) and clusters of Physical, Cognitive, Emotional, and Sleep symptoms. Healthy younger athletes with a concussion history reported greater physical, emotional, and sleep-related symptoms than those with no history of concussion, with a greater endorsement in physical/sleep symptom clusters...
July 5, 2017: Developmental Neuropsychology
https://www.readbyqxmd.com/read/28676987/white-matter-abnormalities-in-mild-traumatic-brain-injury-with-and-without-post-traumatic-stress-disorder-a-subject-specific-diffusion-tensor-imaging-study
#8
Christian Lepage, Amicie de Pierrefeu, Inga K Koerte, Michael J Coleman, Ofer Pasternak, Gerald Grant, Christine E Marx, Rajendra A Morey, Laura A Flashman, Mark S George, Thomas W McAllister, Norberto Andaluz, Lori Shutter, Raul Coimbra, Ross D Zafonte, Murray B Stein, Martha E Shenton, Sylvain Bouix
Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using conventional neuroimaging tools, despite the fact that diffuse axonal injuries are the most common injury. Diffusion tensor imaging (DTI) is sensitive to diffuse axonal injuries and is thus more likely to detect mTBIs, especially when analyses account for the inter-individual variability of these injuries...
July 5, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28665173/serial-assessment-of-gray-matter-abnormalities-following-sport-related-concussion
#9
Lezlie Espana, Ryan Lee, Josef Ling, Andreas Jeromin, Andrew Mayer, Timothy Meier
There is an urgent need to characterize the acute physiological effects of sport-related concussion (SRC). We investigated the effects of SRC on gray matter structure and diffusion metrics in collegiate athletes at 1.64 days (T1; n=33), 8.33 days (T2; n=30), and 32.15 days (T3; n=36) post-concussion, with healthy collegiate contact-sport athletes serving as controls (HA; n=46). Plasma levels of GFAP were assessed in a subset of athletes. We hypothesized that acute SRC would be associated with increased fractional anisotropy (FA), decreased mean diffusivity (MD), and increased GFAP relative to non-injured HA, without acute differences in gray matter volume or cortical thickness...
June 30, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28664033/decreased-susceptibility-of-major-veins-in-mild-traumatic-brain-injury-is-correlated-with-post-concussive-symptoms-a-quantitative-susceptibility-mapping-study
#10
Chao Chai, Rui Guo, Chao Zuo, Linlin Fan, Saifeng Liu, Tianyi Qian, E Mark Haacke, Shuang Xia, Wen Shen
Cerebral venous oxygen saturation (SvO2) is an important biomarker of brain function. In this study, we aimed to explore the relative changes of regional cerebral SvO2 among axonal injury (AI) patients, non-AI patients and healthy controls (HCs) using quantitative susceptibility mapping (QSM). 48 patients and 32 HCs were enrolled. The patients were divided into two groups depending on the imaging based evidence of AI. QSM was used to measure the susceptibility of major cerebral veins. Nonparametric testing was performed for susceptibility differences among the non-AI patient group, AI patient group and healthy control group...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28661827/cumulative-effects-of-concussion-history-on-baseline-computerized-neurocognitive-test-scores-systematic-review-and-meta-analysis
#11
Bara Alsalaheen, Kayla Stockdale, Dana Pechumer, Alexander Giessing, Xuming He, Steven P Broglio
CONTEXT: It is unclear whether individuals with a history of single or multiple clinically recovered concussions exhibit worse cognitive performance on baseline testing compared with individuals with no concussion history. OBJECTIVE: To analyze the effects of concussion history on baseline neurocognitive performance using a computerized neurocognitive test. DATA SOURCES: PubMed, CINAHL, and psycINFO were searched in November 2015. The search was supplemented by a hand search of references...
July 2017: Sports Health
https://www.readbyqxmd.com/read/28657363/assessment-of-motor-cortex-excitability-and-inhibition-during-a-cognitive-task-in-individuals-with-concussion
#12
Eli K Edwards, Anita D Christie
PRIMARY OBJECTIVE: To examine the function of the motor cortex during executive function tasks in individuals with concussion, relative to healthy controls. METHODS AND PROCEDURES: Transcranial magnetic stimulation (TMS) was used to assess motor cortex excitability and inhibition acutely, within 72 hours, and over two months, post-concussion in 23 participants, nine individuals with concussion and 14 controls. Participants performed a cognitive task during TMS to determine the impact of cognitive task on the motor cortex...
June 28, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28655191/iatrogenic-effect-cautions-when-utilizing-an-early-health-education-for-post-concussion-symptoms
#13
Chi-Cheng Yang, Hsiao-Chun Chiu, Sheng-Huang Xiao, Yi-Hsin Tsai, Yi-Chien Lee, Yi-Ting Ku, Rong-Syuan Lin, Wei-Chi Lin, Sheng-Jean Huang
Objective: Patients with mild traumatic brain injury (MTBI) usually suffer from the post-concussion symptoms (PCS). PCS could recover by 3 months post-injury, but some patients still persistently complain of those symptoms for years. Accordingly, the Chang-Gung University Brief Intervention for Post-Concussion Symptoms (CGU-BIPCS) was developed to intervene PCS based on the established advantages of health education. This prospective study thus aims to evaluate the effectiveness of CGU-BIPCS for patients with MTBI...
June 26, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28637118/asymptomatic-chiari-type-i-malformation-should-patients-be-advised-against-participation-in-contact-sports
#14
Robert Spencer, Paul Leach
BACKGROUND: Chiari type I malformation (CM-I) is characterised by caudal displacement of the cerebellar tonsils through the foramen magnum, crowding the craniocervical junction. It is being increasingly diagnosed in asymptomatic patients due to the widespread availability of MRI, and there are case reports of these patients suffering sudden death or neurological injury following head or neck trauma, raising the issue of whether they should be prohibited from contact sport participation, given the likelihood of frequent trauma...
March 2, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28631970/computerized-neuropsychological-test-performance-of-youth-football-players-at-different-positions-a-comparison-of-high-and-low-contact-players
#15
William T Tsushima, Hyeong Jun Ahn, Andrea M Siu, Tama Fukuyama, Nathan M Murata
The aim of this study was to examine the effects of head impact frequency on the neuropsychological test results of football players who participate in different positions on the team. Based on the biomechanical measures of head impact frequency reported in high school football, a High Contact group (n = 480) consisting of offensive and defensive linemen was compared with a Low Contact group (n = 640) comprised of receivers and defensive backs. The results revealed that the High Contact group obtained poorer performances on the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) on three Composite scores (Verbal Memory, Visual Motor Speed, Impulse Control) and the Total Symptom score compared to the Low Contact group...
February 28, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28631965/short-term-test-retest-reliability-of-the-impact-in-healthy-young-athletes
#16
Amanda M O'Brien, Joseph E Casey, Rachel M Salmon
The present study examined the short-term test-retest reliability of the Immediate Post-concussion Assessment and Cognitive Testing (ImPACT) variables with healthy 11- to 14-year-old athletes. 53 young athletes (Mage = 12.4 years, 9 female) were administered the ImPACT on two separate occasions two weeks apart. Participants were instructed to complete the Post-Concussion Symptom Scale (PCSS) and the baseline computerized neurocognitive test during both the baseline and retest phases. Intraclass correlation (ICC), standard error of measurement (SEM), and reliable change index (RCI) were used as reliability metrics...
February 22, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28604837/dynamic-changes-in-diffusion-measures-improve-sensitivity-in-identifying-patients-with-mild-traumatic-brain-injury
#17
Alexander W Thomas, Richard Watts, Christopher G Filippi, Joshua P Nickerson, Trevor Andrews, Gregory Lieberman, Magdalena R Naylor, Margaret J Eppstein, Kalev Freeman
The goal of this study was to investigate patterns of axonal injury in the first week after mild traumatic brain injury (mTBI). We performed a prospective cohort study of 20 patients presenting to the emergency department with mTBI, using 3.0T diffusion tensor MRI immediately after injury and again at 1 week post-injury. Corresponding data were acquired from 16 controls over a similar time interval. Fractional anisotropy (FA) and other diffusion measures were calculated from 11 a priori selected axon tracts at each time-point, and the change across time in each region was quantified for each subject...
2017: PloS One
https://www.readbyqxmd.com/read/28583462/decreased-anticipatory-postural-adjustments-during-gait-initiation-acutely-postconcussion
#18
Thomas A Buckley, Jessie R Oldham, Barry A Munkasy, Kelsey M Evans
OBJECTIVE: To investigate anticipatory postural adjustments (APAs) during the transitional movement task of gait initiation (GI) in individuals acutely after a concussion. DESIGN: Cohort study. SETTING: University research center. PARTICIPANTS: A population-based sample of participants (N=84) divided into 2 equal groups of acutely postconcussion and healthy student athletes. INTERVENTION: Participants were tested on 2 occasions: a preinjury baseline test and then the concussion group was retested acutely postconcussion and the healthy student athlete group again at a similar time...
June 3, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28579327/manipulating-cognitive-reserve-pre-injury-environmental-conditions-influence-the-severity-of-concussion-symptomology-gene-expression-and-response-to-melatonin-treatment-in-rats
#19
Glenn R Yamakawa, Sabrina Salberg, Karen M Barlow, Brian L Brooks, Michael J Esser, Keith Owen Yeates, Richelle Mychasiuk
In an effort to understand the factors that contribute to heterogeneity in outcomes often associated with mTBI in youth, this study examined the role of premorbid differences in cognitive reserve on post-concussive symptoms (PCS), molecular markers, and treatment response. Male and female rats matured in one of three environmental conditions (Stress, Enrichment, Control), received a mTBI in adolescence, and were randomized to melatonin or placebo treatment. All animals underwent a behavioural test battery designed to examine PCS...
June 1, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28570092/the-effect-of-physical-exercise-after-a-concussion-a-systematic-review-and-meta-analysis
#20
Avtar Lal, Stephanie A Kolakowsky-Hayner, Jamshid Ghajar, Maya Balamane
BACKGROUND: Data evaluating the role of exercise in patients with a concussion are contradictory. Studies have reported improvement in the Post-Concussion Symptom Scale (PCSS) score, whereas others showed no effect on the PCSS score. PURPOSE: To conduct a systematic review and meta-analysis on the role of physical exercise on different outcomes in patients with a concussion. STUDY DESIGN: Systematic review and meta-analysis. METHODS: A search of 5 databases from the earliest available date to September 30, 2016, and a hand search of a few articles were performed...
June 1, 2017: American Journal of Sports Medicine
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