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https://www.readbyqxmd.com/read/27924788/effect-of-statins-type-on-incident-prostate-cancer-risk-a-meta-analysis-and-systematic-review
#1
Ping Tan, Chen Zhang, Shi-You Wei, Zhuang Tang, Liang Gao, Lu Yang, Qiang Wei
The aim of this study is to investigate the effect of statins type or even when grouping statins by hydrophilic or hydrophobic nature on prostate cancer risk. A literature search was performed without language restrictions using the databases of PubMed (1984.1-2015.3), MEDLINE (1984.1-2015.3), and EMBASE (1990.1-2015.3). Two independent reviewers appraised eligible studies and extracted data. Weighted averages were reported as relative risk (RR) with 95% confidence intervals (CI). Statistic heterogeneity scores were assessed with the standard Cochran's Q-test and I2 statistic...
December 2, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27923038/comment-on-statin-use-and-all-cancer-survival-prospective-results-from-the-women-s-health-initiative
#2
Luca Mascitelli, Mark R Goldstein
No abstract text is available yet for this article.
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27923034/reply-to-comment-on-statin-use-and-all-cancer-survival-prospective-results-from-the-women-s-health-initiative
#3
Ange Wang, Aaron K Aragaki, Jean Y Tang, Allison W Kurian, JoAnn E Manson, Rowan T Chlebowski, Michael Simon, Pinkal Desai, Sylvia Wassertheil-Smoller, Simin Liu, Stephen Kritchevsky, Heather A Wakelee, Marcia L Stefanick
No abstract text is available yet for this article.
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27891577/statin-use-and-risk-of-endometrial-cancer-a-nationwide-registry-based-case-control-study
#4
Cecilie Dyg Sperling, Freija Verdoodt, Søren Friis, Christian Dehlendorff, Susanne K Kjaer
INTRODUCTION: Laboratory and epidemiological evidence have suggested that statin use may protect against the development of certain cancers, including endometrial cancer. In a nationwide registry-based case-control study, we examined the association between statin use and risk of endometrial cancer. MATERIAL AND METHODS: Cases were female residents of Denmark with a primary diagnosis of endometrial cancer during 2000-2009. For each case, we selected 15 female population controls matched on date of birth (± 1 month) using risk-set sampling...
November 27, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27890326/the-effect-of-metabolic-comorbidities-and-commonly-used-drugs-on-the-prognosis-of-patients-with-ovarian-cancer
#5
Daniel Bar, Ofer Lavie, Nili Stein, Ido Feferkorn, Ayelet Shai
BACKGROUND: Diabetes mellitus is associated with an increased risk of recurrence in patients with ovarian cancer. Retrospective studies suggested that the use of statins, metformin and beta blockers is associated with improved prognosis in these patients. Patients with diabetes often suffer from hypertension and are usually treated concomitantly by several classes of drugs. Our aim was to assess the independent contribution of diabetes mellitus and hypertension and of the use of aspirin, statins, metformin and beta blockers on the risk of ovarian cancer recurrence and mortality...
October 14, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27888870/latest-advances-in-pancreatic-tumours
#6
José Lariño Noia
Pancreatic cancer continues to have a bleak prognosis. Hardly any therapeutic advances have been made in the last few years and consequently most efforts have focused on preventing its development and on diagnosing precursor lesions. In this regard, the use of statins as a preventive factor and the implementation of screening programmes in high-risk patients are gaining ground. In the field of treatment, there is greater focus on the role of neoadjuvant therapy in pancreatic cancer and on a multimodal approach to the disease, with few advances in effective novel therapies...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27885164/relation-of-statin-use-with-non-melanoma-skin-cancer-prospective-results-from-the-women-s-health-initiative
#7
EDITORIAL
Ange Wang, Jean Y Tang, Marcia L Stefanick
No abstract text is available yet for this article.
September 2016: Women's Health
https://www.readbyqxmd.com/read/27875557/socioeconomic-status-and-poor-health-outcome-at-10-years-of-follow-up-in-the-multi-ethnic-study-of-atherosclerosis
#8
Steven Shea, Joao Lima, Ana Diez-Roux, Neal W Jorgensen, Robyn L McClelland
BACKGROUND/OBJECTIVES: Predictors of healthy aging have not been well-studied using longitudinal data with demographic, clinical, subclinical, and genetic information. The objective was to identify predictors of poor health outcome at 10 years of follow-up in the Multi-Ethnic Study of Atherosclerosis (MESA). DESIGN: Prospective cohort study. SETTING: Population-based sample from 6 U.S. communities. PARTICIPANTS: 4,355 participants In the MESA Study...
2016: PloS One
https://www.readbyqxmd.com/read/27872797/lovastatin-lowers-the-risk-of-breast-cancer-a-population-based-study-using-logistic-regression-with-a-random-effects-model
#9
Rimi Murakami, Chiehfeng Chen, Shu-Yu Lyu, Ching-En Lin, Pei-Chuan Tzeng, Tzu-Feng Wang, Juei-Chin Chang, Ying-Hua Shieh, I-Fan Chen, Shihping Kevin Huang, Hui-Wen Lin
BACKGROUND: Laboratory studies have demonstrated statin-induced apoptosis of cancer cells, including breast cancer cells, and evidence is accumulating on the mechanism of statin-induced apoptosis. However, despite numerous epidemiological studies, no consensus has been reached regarding the relationship between statin use and breast cancer risk. METHODS: This retrospective case-control study enrolled 4332 breast cancer patients and 21,660 age-matched controls registered in the National Health Insurance program of Taiwan, which covers approximately 99% of the population...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27869439/immunology-update-long-term-care-of-solid-organ-transplant-recipients
#10
S Paul Starr
Nearly 31,000 US patients received solid organ transplants in 2015 and the number is increasing. Care of transplant recipients includes management of a variety of common posttransplantation issues. Skin cancers are common because of immunosuppression and require skin examinations at intervals. Patients should be educated about the need to report new skin lesions. The rates of other cancers also are increased, including cancers of the head and neck, lung, esophagus, cervix, and urinary tract. Osteoporosis is common in transplant recipients; monitoring and early therapy are important...
November 2016: FP Essentials
https://www.readbyqxmd.com/read/27869438/immunology-update-biologics
#11
S Paul Starr
Biologics are substances made from a living organism or its products. These include genes, proteins (eg, antibodies, receptors, enzymes, inhibitors), recombinant proteins, and fusion proteins. Biologics often are produced using recombinant DNA technology. For example, monoclonal antibodies are produced by inserting human genes into immortalized cell cultures, which then produce the gene product (ie, an antibody) in large quantity. Another approach is to fuse genetic material from nonhuman sources (eg, mice) with human genetic material...
November 2016: FP Essentials
https://www.readbyqxmd.com/read/27867302/current-and-emerging-uses-of-statins-in-clinical-therapeutics-a-review
#12
REVIEW
Jonathan T Davies, Spencer F Delfino, Chad E Feinberg, Meghan F Johnson, Veronica L Nappi, Joshua T Olinger, Anthony P Schwab, Hollie I Swanson
Statins, a class of cholesterol-lowering medications that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, are commonly administered to treat atherosclerotic cardiovascular disease. Statin use may expand considerably given its potential for treating an array of cholesterol-independent diseases. However, the lack of conclusive evidence supporting these emerging therapeutic uses of statins brings to the fore a number of unanswered questions including uncertainties regarding patient-to-patient variability in response to statins, the most appropriate statin to be used for the desired effect, and the efficacy of statins in treating cholesterol-independent diseases...
2016: Lipid Insights
https://www.readbyqxmd.com/read/27864002/gamma-tocotrienol-reverses-multidrug-resistance-of-breast-cancer-cells-with-a-mechanism-distinct-from-that-of-atorvastatin
#13
Yuedi Ding, Ying Peng, Lili Deng, Jun Fan, Biao Huang
In addition to its antioxidant properties, γ-tocotrienol also has the ability to inhibit HMG-CoA reductase, which is the key enzyme in the mevalonate pathway for cholesterol biosynthesis. Statins, the competitive inhibitors of HMG-CoA reductase, display potent anticancer activity and reversal ability of multidrug resistance in a variety of tumor cells, which is believed to be due to their inhibition of HMG-CoA reductase. Here, we determined the role of the mevalonate pathway in γ-tocotrienol-mediated reversal of multidrug resistance in cancer cells...
November 15, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27862098/simvastatin-up-regulates-annexin-a10-that-can-inhibit-the-proliferation-migration-and-invasion-in-androgen-independent-human-prostate-cancer-cells
#14
Yoshiyuki Miyazawa, Yoshitaka Sekine, Haruo Kato, Yosuke Furuya, Hidekazu Koike, Kazuhiro Suzuki
BACKGROUND: Statins have recently been studied for their proapoptotic and antimetastatic effects. However, the exact mechanisms of their anticancer actions remain unclear. Using microarrays, we discovered up-regulation of annexin A10 (ANXA10) in PC-3 cells after simvastatin treatment. ANXA10 reportedly has antitumor effects. In this study, we evaluated the effects of simvastatin on ANXA10 signaling in androgen-independent prostate cancer cells. METHODS: PC-3, LNCaP-LA (which were derived from LNCaP cells and cultured in 10% charcoal-stripped fetal bovine serum for 3 months), and DU145 human prostate cancer cell lines were used...
November 8, 2016: Prostate
https://www.readbyqxmd.com/read/27861855/effect-of-statin-on-hepatocellular-carcinoma-in-patients-with-type-2-diabetes-a-nationwide-nested-case-control-study
#15
Gyuri Kim, Suk-Yong Jang, Eugene Han, Yong-Ho Lee, Se-Young Park, Chung Mo Nam, Eun Seok Kang
Relationship on new statin use and the risk of hepatocellular carcinoma (HCC) in patients with incident type 2 diabetes mellitus (T2DM), who might be at the risk of developing HCC, is uncertained. A nationwide population-based nested case-control study was conducted within the National Health Insurance Service National Sample Cohort 2002-2013 in Korea. Newly prescribed statin after newly diagnosed T2DM was defined as statin use. Controls were matched to case patients on age, sex, follow-up time, and the date of diabetes diagnosis at a five-to-one ratio...
November 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27859151/effects-of-statins-on-cancer-mortality-and-progression-a-systematic-review-and-meta-analysis-of-95-cohorts-including-1111407-individuals
#16
Zubing Mei, Mining Liang, Lezhi Li, Yi Zhang, Qingming Wang, Wei Yang
Statins have been implicated in the regulation of cell proliferation, apoptosis and tumor progression in cancer patients and statin use at the time of cancer diagnosis has been reported to be associated with reduced cancer risk and improved survival, irrespective of concomitant anti-cancer therapy. A systematic literature search of relevant databases through May 2015 was conducted to identify studies assessing the prognostic impact of statin use on prognostic outcomes in cancer patients. Literature search identified 95 cohort studies that met the inclusion criteria...
November 18, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27853392/statins-and-risk-of-breast-cancer-recurrence
#17
Minas Sakellakis, Karolina Akinosoglou, Anastasia Kostaki, Despina Spyropoulou, Angelos Koutras
BACKGROUND: The primary end point of our study was to test whether the concurrent use of a statin is related to a lower risk of recurrence and increased relapse-free survival in patients with early breast cancer. MATERIALS AND METHODS: We reviewed 610 female patients with stage I, II, or III breast cancer who had been surgically treated and who had subsequently received at least adjuvant chemotherapy in order to prevent recurrence. RESULTS: Among the 610 patients with breast cancer, 83 (13...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27836464/apoptotic-effect-of-atorvastatin-in-glioblastoma-spheroids-tumor-cultured-in-fibrin-gel
#18
Neda Bayat, Somayeh Ebrahimi-Barough, Abbas Norouzi-Javidan, Hooshang Saberi, Roksana Tajerian, Mohammad Mehdi Mokhtari Ardakan, Sadegh Shirian, Arman Ai, Jafar Ai
OBJECTIVE: Glioblastoma multiform (GBM) is one of the most common and highly aggressive primary brain tumors that thought to be of glial cells origin. The new available therapy for glioblastoma is based on better understanding of molecular malignant progression in this tumor. It is better to identify key molecular targets stimulating signaling pathways that lead to initiation of apoptosis for treatment of glioblastoma. Tumorigenesis broadly is controlled by tumor microenvironment and design of best biomimetic culture systems dependency on these conditions allow for in vitro and in vivo tumor modeling for studies of cancer cells behavior to drugs...
November 8, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27833018/additive-inhibitory-effects-of-simvastatin-and-enzalutamide-on-androgen-sensitive-lncap-and-vcap-prostate-cancer-cells
#19
Heimo Syvälä, Pasi Pennanen, Merja Bläuer, Teuvo L J Tammela, Teemu J Murtola
We evaluated the effects of simvastatin and antiandrogen enzalutamide on growth and androgen signaling in androgen-sensitive LNCaP and VCaP prostate cancer cells. Simvastatin alone abolished androgen-induced growth in both cell lines but decreased androgen receptor (AR) and prostate-specific antigen protein expression only in LNCaP, indicating that statin-induced growth inhibition is beyond AR transcriptional activity in VCaP. Combination of simvastatin and enzalutamide exerted additive growth inhibition in both cell lines accompanied with strong induction of autophagy in LNCaP...
December 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27826756/characteristics-associated-with-nonadherence-to-medications-for-hypertension-diabetes-and-dyslipidemia-among-breast-cancer-survivors
#20
Gregory S Calip, Joann G Elmore, Denise M Boudreau
OBJECTIVE: Comorbidity among breast cancer survivors is prevalent, and adherence to medication management of comorbidities may be important for both chronic disease and cancer-related outcomes. Our objective was to determine characteristics associated with nonadherence to common chronic medications among breast cancer survivors. METHODS: We conducted a retrospective cohort study of 4216 women in an integrated care system diagnosed with early-stage breast cancer between 1990 and 2008 and alive without recurrence or second primary breast cancer in the second-year following diagnosis...
November 8, 2016: Breast Cancer Research and Treatment
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