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Hongli Sun, Qian Su, Huifang Zhang, Weimin Liu, Huiping Zhang, Ding Ding, Zhongliang Zhu, Hui Li
PURPOSE: To clarify the alterations of proliferation and differentiation of hippocampal cells in prenatally stressed rats. METHODS: We investigated the impact of prenatal restraint stress on the hipocampal cell proliferation in the progeny with 5-bromo-2'-deoxyuridine (BrdU), which is a marker of proliferating cells and their progeny. In addition, we observed the differentiation of neural stem cells (NSCs) with double labeling of BrdU/neurofilament (NF), BrdU/glial fibrillary acidic protein (GFAP) in the hipocampus...
June 2015: Brain & Development
Y Lu, F Zhong, X Wang, H Li, Z Zhu, X Kong, J Zhao, Q Wu
OBJECTIVE: The effects of motilin on voltage-dependent K+ currents in hippocampal neurons with the addition of L-arginine (L-AA), D-arginine (D-AA) and N-nitro-L-arginine methyl ester (L-NAME) were investigated in this study. METHODS: Mice (1-3 days old) were randomly assigned to different groups according to the addition of motilin, L-AA, D-AA, and L-NAME. The K+ current signals were detected by the whole-cell patch-clamp technique. RESULTS: Compared with the control group, the transient outward voltage-dependent K+ current was significantly inhibited by motilin added with L-AA...
January 22, 2015: Neuroscience
Luis H Llano López, Fernando Caif, Miriam Fraile, Belén Tinnirello, Adriana I Landa de Gargiulo, José V Lafuente, Gustavo C Baiardi, Pascual A Gargiulo
BACKGROUND: The effect of the agonism on γ-aminobutyric acid (GABA) receptors was studied within medial prefrontal cortex (mPFC), amygdala (AMY) and ventral hipocampus (VH) in the plus-maze test in male rats bilaterally cannulated. These structures send glutamatergic projections to the nucleus accumbens septi (NAS), in which interaction and integration between these afferent pathways has been described. In a previous study of our group, blockade of glutamatergic transmission within NAS induced an anxiolytic like effect...
2013: Pharmacological Reports: PR
Nazan Uysal, Basak Baykara, Muge Kiray, Ferihan Cetin, Ilkay Aksu, Ayfer Dayi, Tugba Gurpinar, Durgul Ozdemir, M Nuri Arda
AIM: It is well known that head trauma results in damage in hippocampal and cortical areas of the brain and impairs cognitive functions. The aim of this study is to explore the neuroprotective effect of combination therapy with magnesium sulphate (MgSO4) and progesterone in the 7-days-old rat pups subjected to contusion injury. MATERIAL AND METHODS: Progesterone (8 mg/kg) and MgSO4 (150 mg/kg) were injected intraperitoneally immediately after induction of traumatic brain injury...
2013: Turkish Neurosurgery
Thiago L N Lazaroni, Ana Cláudia S Raslan, Walkiria R P Fontes, Marilene L de Oliveira, Michael Bader, Natalia Alenina, Márcio F D Moraes, Robson A Dos Santos, Grace S Pereira
It has been shown that the brain has its own intrinsic renin-angiotensin system (RAS) and angiotensin-(1-7) (Ang-(1-7)) is particularly interesting, because it appears to counterbalance most of the Ang II effects. Ang-(1-7) exerts its biological function through activation of the G-protein-coupled receptor Mas. Interestingly, hippocampus is one of the regions with higher expression of Mas. However, the role of Ang-(1-7)/Mas axis in hippocampus-dependent memories is still poorly understood. Here we demonstrated that Mas ablation, as well as the blockade of Mas in the CA1-hippocampus, impaired object recognition memory (ORM)...
January 2012: Neurobiology of Learning and Memory
N Li, Z L Yu, L Wang, Y T Zheng, J X Jia, Q Wang, M J Zhu, X L Liu, X Xia, W J Li
The aim of this study was to investigate the effects of maternal lead exposure on the learning and memory ability and expression of tau protein phosphorylation (P-tau) and beta amyloid protein (Abeta) in hippocampus of mice offspring. Pb exposure initiated from beginning of gestation to weaning. Pb acetate administered in drinking solutions was dissolved in distilled deionized water at the concentrations of 0.1%, 0.5% and 1% groups. On the 21 th of postnatal day, the learning and memory ability of the mouse pups was tested by Water Maze test and the Pb levels in blood and hippocampus of the offspring were also determined...
June 2010: Acta Biologica Hungarica
Przemysław Nowak, Lukasz Noras, Jerzy Jochem, Ryszard Szkilnik, Halina Brus, Eva Körossy, Jacek Drab, Richard M Kostrzewa, Ryszard Brus
Rats lesioned shortly after birth with 6-OHDA have been proposed to be a near-ideal model of severe Parkinson's disease, because of non-lethality of the procedure, near-total destruction of nigrostriatal dopaminergic fibers, and near-total dopamine (DA) denervation of striatum. There are scarce data that in Parkinson's disease, activity of the central histaminergic system is increased. Therefore, the aim of this study was to determine histamine content in the brain and the effect of histamine receptor antagonists on behavior of adult rats...
April 2009: Neurotoxicity Research
V N Babichev
The paper provides a generalization of data and the results of own experiments on influence ovarian steroids on the hypothalamus and other brain areas related to reproduction. Ovarian hormones have widespread effects throughout the brain: on catecholaminergic neurons and serotonergic pathways and the basal forebrain cholinergic system, as well as the hipocampus, spinal cord, nigrostriatal and mesolimbic system, in addition to glial cells and blood-brain barrier. The widespread influences of these various neuronal systems ovarian steroids have measurable effects on mood and affect as well as on cognition, with implications for dementia...
January 2005: Uspekhi Fiziologicheskikh Nauk
Glenda Alquicer, Adriana B Silva-Gómez, Fernando Peralta, Gonzalo Flores
The neonatal ventral Hippocampus (nVH) lesion in rats has been used as a model to test the hypothesis that early neurodevelopmental abnormalities lead to behavioral changes putatively linked to schizophrenia. The schizophrenic patients tend to social isolation. In addition, considerable evidence from behavioral and neurochemistry studies strongly implicate the dopamine (DA) system and the medial part of the prefrontal cortex (mPFC) in the pathophysiology of the social isolation syndrome. In order to assess effects of the postweaning social isolation (pwSI) on the DA system of the nVH lesions, we investigated the DA content and its metabolite, DOPAC in different limbic subregions in rats postpubertally at postnatal day (P) 78 following nVH lesions at P7 with and without pwSI for 8 weeks...
April 2004: International Journal of Developmental Neuroscience
Ramona R. Hicks, Arden Boggs, Denise Leider, Philip Kraemer, Russell Brown, Stephen W. Scheff, Kim B. Seroogy
Previous studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in memory and learning, and may be neuroprotective following various brain insults. Exercise has been found to increase BDNF mRNA levels in various brain regions, including specific subpopulations of hippocampal neurons. In the present study, we were interested in whether following traumatic brain injury, exercise could increase BDNF mRNA expression, attenuate neuropathology, and improve cognitive and neuromoter performance...
1998: Restorative Neurology and Neuroscience
J A Abreu Reyes, M Gonzalez de la Rosa, M Sanchez Mendez, C G Mesa Moreno, R Santos Barrera
An evaluation was carried out comparing Oculokinetic Perimetry (O.K.P.) with Automatic Perimetry of Thresholds (Hipocampus Perimeter) for ocular hypertension and glaucoma studying 145 eyes. The O.K.P. shows a sensitivity between 35.65 and 38.54%, a specificity of 76.67-79.59%, a + predictive value of 78.72-85.42%, and a-predictive value of 23.71-39.80%.
September 1992: International Ophthalmology
A Iu Budantsev, A D Gur'ianova
The hippocampal formation (the hippocampus and the dentate fascia) of the rabbit was studied by histochemical fluorescent method of Falk to determine localization of monoaminergic terminals containing biogenic amines: noradrenalin, dophamine and serotonin. It was shown that monoaminenergic terminals in the hippocampus were in two zones of afferent terminations: in the zone of ending of the perforating way (str. lacunosum-moleculare of fields CA1 and CA2; str. moleculare of the dentate fascia) and in the subgranular zone of the hilum where a part of septofimbrial way terminated on granular neurons of the dentate fascia, the main cellular elements of the hipocampus (pyramidal, granular and basket cells of the hippocampus) did not contain biogenic amines...
June 1975: Arkhiv Anatomii, Gistologii i émbriologii
J Wenzel, H David, W Pohle, I Marx, H Matthies
The ribosomes of the CA1 and CA3 pyramidal cells of hipocampus were investigated by morphometric methods after the acquisition of a shock-motivated brightness discrimination in rats. A significant increase in the total number of ribosomes was observed in CA1 cells of trained animals and in CA3 cells of both active controls and trained rats. A significant increase in membrane-bound ribosomes was obtained in CA1 and CA3 cells after training only. The results confirm the suggestion of an increased protein synthesis in hippocampal neurons during and after the acquisition of a brightness discrimination, as we have concluded from out previous investigations on the incorporation of labeled amino acids under identical experimental conditions...
January 24, 1975: Brain Research
J David, R S Grewal
Qualitative and quantitative aspects of chronic carbamazepine (Tegretol) medication on focal seizures and associated interictal EEG abnormalities in Rhesus monkeys with alumina-induced foci in either the sensorimotor cortex or the hipocampus was investigated. In both groups of animals, carbamazepine produced qualitative control of visible seizures and reduced intracortical spike propagation, but did not cause complete normalization of the background EEG; quantitative indices, such as spike density and amount of paroxysmal discharge representative of abnormal EEG activity, were significantly reduced with respect to predrug values during medication and after cessation as well...
December 1976: Epilepsia
J Deroo, G B Gerber
A method is described to measure regional blood flow in different structures of the rat brain. Microspheres (15 micron) are injected, the brain is sectioned, stained for myeline, radioautographs are prepared and the microspheres in the different structures are counted. The values obtained for different brain structures are counted. The values obtained for different brain regions (cortex, corpus callosum, thalamus hipocampus, hypothalamic region, colliculi, cerebellum, pons, medulla) compare well with those published by others on larger animals...
1976: Comptes Rendus des Séances de la Société de Biologie et de Ses Filiales
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