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Neurotrophin

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https://www.readbyqxmd.com/read/28719101/neuronal-degeneration-and-regeneration-induced-by-axotomy-in-the-olfactory-epithelium-of-xenopus-laevis
#1
A S Cervino, D A Paz, J L Frontera
The olfactory epithelium (OE) has the remarkable capability to constantly replace olfactory receptor neurons (ORNs) due to the presence of neural stem cells (NSCs). For this reason, the OE provides an excellent model to study neurogenesis and neuronal differentiation. In the present work, we induced neuronal degeneration in the OE of Xenopus laevis larvae by bilateral axotomy of the olfactory nerves. We found that axotomy induces specific- neuronal death through apoptosis between 24 and 48h post-injury. In concordance, there was a progressive decrease of the mature-ORN marker OMP until it was completely absent 72h post-injury...
July 18, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28713816/effect-of-the-camelid-s-seminal-plasma-ovulation-inducing-factor-%C3%AE-ngf-a-kisspeptin-target-hypothesis
#2
REVIEW
Khalid El Allali, Najlae El Bousmaki, Hassan Ainani, Valérie Simonneaux
Female mammals are classified into spontaneous and induced ovulators based on the mechanism eliciting ovulation. Ovulation in spontaneous species (e.g., human, sheep, cattle, horse, pigs, and most rodents) occurs at regular intervals and depends upon the circulating estradiol. However, in induced ovulators (e.g., rabbits, ferrets, cats, and camelids), ovulation is associated with coitus. In the later, various factors have been proposed to trigger ovulation, including auditory, visual, olfactory, and mechanic stimuli...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28713531/the-effects-of-fasting-during-ramadan-on-the-concentration-of-serotonin-dopamine-brain-derived-neurotrophic-factor-and-nerve-growth-factor
#3
Abdolhossein Bastani, Sadegh Rajabi, Fatemeh Kianimarkani
Neurotransmitters and neurotrophic factors are signaling molecules that play a crucial role in cell proliferation, differentiation, survival and functions of neurons. It is believed that caloric restriction could help the health of the nervous system by affecting the synthesis of neurotrophins and neurotransmitter and oxygen radical metabolism. The objective was to investigate the plasma levels of serotonin, dopamine, brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in 29 healthy fasted subjects (22 women and 7 men) during the month of fasting in Ramadan...
June 23, 2017: Neurology International
https://www.readbyqxmd.com/read/28710704/systemic-analysis-of-mirnas-in-pd-stress-condition-mir-5701-modulates-mitochondrial-lysosomal-cross-talk-to-regulate-neuronal-death
#4
Paresh Prajapati, Lakshmi Sripada, Kritarth Singh, Milton Roy, Khyati Bhatelia, Pooja Dalwadi, Rajesh Singh
Parkinson's disease (PD) is complex neurological disorder and is prevalent in the elderly population. This is primarily due to loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) region of the brain. The modulators of the selective loss of dopaminergic neurons in PD are still not well understood. The small non-coding RNAs specifically miRNAs fine-tune the protein levels by post-transcriptional gene regulation. The role of miRNAs in PD pathogenesis is still not well characterized. In the current study, we identified the miRNA expression pattern in 6-OHDA-induced PD stress condition in SH-SY5Y, dopaminergic neuronal cell line...
July 14, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28710695/serum-brain-derived-neurotrophic-factor-levels-in-treatment-na%C3%A3-ve-boys-with-attention-deficit-hyperactivity-disorder-treated-with-methylphenidate-an-8-week-observational-pretest-posttest-study
#5
Aynur Pekcanlar Akay, Halil Resmi, Sevay Alsen Güney, Handan Özek Erkuran, Gonca Özyurt, Enis Sargin, Ahmet Topuzoglu, Ali Evren Tufan
Brain-derived neurotrophic factor (BDNF) is an important neurotrophin in the brain that modulates dopaminergic neurons. In this study, we aimed to investigate the changes in serum BDNF levels of children with attention-deficit/hyperactivity disorder (ADHD) in response to OROS methylphenidate treatment. We also aimed to determine whether there were any pre-post-differences between ADHD subtypes and comorbid psychiatric disorders in serum BDNF levels. Fifty male children with ADHD and 50 male healthy controls within the age range of 6-12 years were recruited to the study...
July 14, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28708822/an-ancient-neurotrophin-receptor-code-a-single-runx-cbf%C3%AE-complex-determines-somatosensory-neuron-fate-specification-in-zebrafish
#6
Philia Gau, Andrew Curtright, Logan Condon, David W Raible, Ajay Dhaka
In terrestrial vertebrates such as birds and mammals, neurotrophin receptor expression is considered fundamental for the specification of distinct somatosensory neuron types where Traka, TrkB and TrkC specify nociceptors, mechanoceptors and proprioceptors/mechanoceptors, respectively. In turn, Runx transcription factors promote neuronal fate specification by regulating neurotrophin receptor and sensory receptor expression where Runx1 mediates TrkA+ nociceptor diversification while Runx3 promotes a TrkC+ proprioceptive/mechanoceptive fate...
July 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28699521/astrocyte-an-innovative-approach-for-alzheimer-s-disease-therapy
#7
Maria Rosanna Bronzuoli, Roberta Facchinetti, Luca Steardo, Caterina Scuderi
Alzheimer's disease is a devastating neurological illness with a heavy economic impact. Further comorbidity in combination with the social impact of this disorder increases the urgency of a clearer comprehension of its etiopathogenesis, allowing the execution of novel therapeutic strategies. Despite astrocytes have been widely described as active participant in the regulation of cerebral circuits, available data are still poor. Even less information is available about their precise role in the pathogenesis of illness...
July 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28698670/urinary-extracellular-domain-of-neurotrophin-receptor-p75-as-a-biomarker-for-amyotrophic-lateral-sclerosis-in-a-chinese-cohort
#8
Rui Jia, Stephanie Shepheard, Jiaoting Jin, Fangfang Hu, Xing Zhao, Li Xue, Li Xiang, Huaguang Qi, Qiumin Qu, Feng Guo, Mary-Louise Rogers, Jingxia Dang
To comprehensively assess whether p75(ECD) in urine could be a candidate biomarker for ALS evaluation. Urine samples were collected from 101 ALS patients, 108 patients with other neurological disease (OND) and 97 healthy controls. 61 ALS patients were followed up with clinical data including ALSFRS-r every 6 to 12 months, 23 ALS patients died and 17 ALS patients lost touch during follow up period. Enzyme-linked immunoassay was employed to determine urine p75(ECD) concentration. The ALSFRS-r was employed to assess the severity of ALS...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28690836/noise-induced-and-age-related-hearing-loss-%C3%A2-new-perspectives-and-potential-therapies
#9
REVIEW
M Charles Liberman
The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view. In noise-induced hearing loss, exposures causing only reversible threshold shifts (and no hair cell loss) nevertheless cause permanent loss of >50% of the synaptic connections between hair cells and the auditory nerve. Similarly, in age-related hearing loss, degeneration of cochlear synapses precedes both hair cell loss and threshold elevation...
2017: F1000Research
https://www.readbyqxmd.com/read/28687505/xiaochaihutang-attenuates-depressive-anxiety-like-behaviors-of-social-isolation-reared-mice-by-regulating-monoaminergic-system-neurogenesis-and-bdnf-expression
#10
Jie Ma, Fang Wang, Jingyu Yang, Yingxu Dong, Guangyue Su, Kuo Zhang, Xing Pan, Ping Ma, Tingshuo Zhou, Chunfu Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Xiaochaihutang (XCHT), as a classical herbal formula for the treatment of "Shaoyang syndrome" has been demonstrated to exert an antidepressant effect in multiple animal models of depression as shown in our previous studies. However, the effects of XCHT on social isolation (SI)-reared mice have not been investigated. This study aims to explore the effects of XCHT on depressive/anxiety-like behaviors of SI-reared mice, and its implicated mechanisms, including alterations in the monoaminergic system, neurogenesis and neurotrophin expression...
July 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28682396/nanoscale-clustering-of-the-neurotrophin-receptor-trkb-revealed-by-super-resolution-sted-microscopy
#11
Borislav Angelov, Angelina Angelova
The nanoscale organization of the tropomyosin-related kinase receptor type B (TrkB), a promising therapeutic target for severe neurodegenerative and psychiatric disorders, is examined by stimulated emission depletion (STED) microscopy using the deconvoluted gated STED option. The performed immunofluorescence nanoscopic subdiffraction imaging of the membrane receptor localization reveals that clusters of oligomeric TrkB states and randomly organized nanodomains are formed in the membranes of differentiated human neuroblastoma SH-SY5Y cells, which are studied as an in vitro model of neurodegeneration...
July 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28680965/a-brain-derived-neurotrophic-factor-based-p75-ntr-peptide-mimetic-ameliorates-experimental-autoimmune-neuritis-induced-axonal-pathology-and-demyelination
#12
David G Gonsalvez, Giang Tran, Jessica L Fletcher, Richard A Hughes, Suzanne Hodgkinson, Rhiannon J Wood, Sang Won Yoo, Mithraka De Silva, Wong W Agnes, Catriona McLean, Paul Kennedy, Trevor J Kilpatrick, Simon S Murray, Junhua Xiao
Axonal damage and demyelination are major determinants of disability in patients with peripheral demyelinating neuropathies. The neurotrophin family of growth factors are essential for the normal development and myelination of the peripheral nervous system (PNS), and as such are potential therapeutic candidates for ameliorating axonal and myelin damage. In particular, BDNF promotes peripheral nerve myelination via p75 neurotrophin receptor (p75(NTR)) receptors. Here, we investigated the therapeutic efficacy of a small structural mimetic of the region of BDNF that binds to p75(NTR) (cyclo-dPAKKR) in experimental autoimmune neuritis (EAN), an established animal model of peripheral demyelinating neuropathy...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28680451/the-proliferation-enhancing-effects-of-salidroside-on-schwann-cells-in-vitro
#13
Hui Liu, Peizhen Lv, Huayu Wu, Kun Zhang, Fuben Xu, Li Zheng, Jinmin Zhao
Derived from Rhodiola rosea L., which is a popular plant in Eastern Europe and Asia, salidroside has pharmacological properties including antiviral, anticancer, hepatoprotective, antidiabetic, and antioxidative effects. Recent studies show that salidroside has neurotrophic and neuroprotective effects. However, the effect of salidroside on Schwann cells (SCs) and the underlying mechanisms of the salidroside-induced neurotrophin secretion have seldom been studied. In this study, the effect of salidroside on the survival, proliferation, and gene expression of Schwann cells lineage (RSC96) was studied through the examinations of the cell viability, proliferation, morphology, and expression of neurotrophic factor related genes including BDNF, GDNF, and CDNF at 2, 4, and 6 days, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28678563/effect-of-brain-derived-neurotrophic-factor-bdnf-on-sperm-quality-of-normozoospermic-men
#14
Hassan Safari, Neda Khanlarkhani, Aligholi Sobhani, Atefeh Najafi, Fardin Amidi
The neurotrophin family of proteins and their receptors act as important proliferative and pro-survival factors in differentiation of nerve cells and are thought to play key roles in the development of reproductive tissues and normal function of spermatozoa. The objective of the present study was to evaluate the effect of Brain-Derived Neurotrophic Factor (BDNF) on the sperm viability and motility, lipid peroxidation (LPO), mitochondrial activity and concentration of leptin, nitric oxide (NO) and insulin in normozoospermic men...
July 5, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28672981/neurotrophic-factor-and-trk-signaling-mechanisms-underlying-the-promotion-of-motor-recovery-after-acute-spinal-cord-injury-in-rats
#15
Hua Fang, Chong Liu, Miao Yang, Huafeng Li, Fangxiang Zhang, Weijing Zhang, Jianping Zhang
Neurotrophic factor (NF) and Trk signaling mechanisms underlying the promotion of motor recovery following acute spinal cord injury (SCI) in rats were investigated. Thirty-six adult Sprague-Dawley rats of both genders were randomly divided into three groups: Sham-operated, model, and NF/Trk. Each group consisted of 12 rats, with four subgroups in each group: 1, 3, 5 and 7 days. Sham-operated rats received a laminectomy without SCI, while in model group rats, SCI was induced using an improved version of the Allen's method...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28659008/pain-mechanisms-in-peritoneal-diseases-might-be-partially-regulated-by-estrogen
#16
Clara Börner, Claudia Scheerer, Rene Buschow, Vito Chiantera, Jalid Sehouli, Sylvia Mechsner
To identify factors influencing the differential pain pathogenesis in peritoneal endometriosis (pEM) and peritoneal carcinomatosis in ovarian cancer (pOC), we undertook an experimental study. Tissue samples of 18 patients with pEM, 15 patients with pOC, and 15 unaffected peritoneums as controls were collected during laparoscopy or laparotomy. Immunohistochemical stainings were conducted to identify nerve fibers and neurotrophins in the tissue samples. Additionally, 23 pEM fluids, 25 pOC ascites fluids, and 20 peritoneal fluids of patients with myoma uteri as controls were collected...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28658664/differential-gene-and-lncrna-expression-in-the-lower-thoracic-spinal-cord-following-ischemia-reperfusion-induced-acute-kidney-injury-in-rats
#17
Qing-Quan Liu, Hui Liu, Zhi-Gang He, Shi-Jie Zhang, Bao-Wen Liu, Le Wang, Wen-Hui Qiu, Qing Xu, Hong-Bing Xiang, Yong-Man Lv
We used high-throughput RNA sequencing to analyze differential gene and lncRNA expression patterns in the lower thoracic spinal cord during ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) in rats. We observed that of 32662 mRNAs, 4296 out were differentially expressed in the T8-12 segments of the spinal cord upon I/R-induced AKI. Among these, 62 were upregulated and 34 were downregulated in response to I/R (FDR < 0.05, |log2FC| > 1). Further, 52 differentially expressed lncRNAs (35 upregulated and 17 downregulated) were identified among 3849 lncRNA transcripts...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654784/generation-and-characterization-of-a-human-oral-squamous-carcinoma-cell-line-scc-9-with-crispr-cas9-mediated-deletion-of-the-p75-neurotrophin-receptor
#18
Ping Huang, Dongdong Tong, Jing Sun, Qing Li, Fenghe Zhang
OBJECTIVE: To investigate the importance of the p75 neurotrophin receptor (p75(NTR)) in human tongue squamous carcinoma cells, we exploited the CRISPR/Cas9 technology to establish a p75(NTR)-knockout SCC-9 cell line and to explore the effect on biological functions. MATERIALS AND METHODS: The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated endonuclease (Cas9) system was used to generate genomic deletion mutants of p75(NTR) in the tongue squamous carcinoma cell lines SCC-9...
June 24, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28654221/high-salt-diet-impairs-memory-related-synaptic-plasticity-via-increased-oxidative-stress-and-suppressed-synaptic-protein-expression
#19
Qian Ge, Zhengjun Wang, Yuwei Wu, Qing Huo, Zhaoqiang Qian, Zhongmin Tian, Wei Ren, Xia Zhang, Jing Han
SCOPE: A high salt (HS) diet is detrimental to cognitive function, in addition to having a role in cardiovascular disorders. However, the method by which a HS diet impairs cognitive functions such as learning and memory remains open. METHODS AND RESULTS: In this study, we found that mice on a 7 week HS diet demonstrated disturbed short-term memory in an object-place recognition task, and both 4 week and 7 week HS treatments impaired long-term memory, as evidenced in a fear conditioning test...
June 27, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28654072/subcutaneous-neurotrophin-4-infusion-using-osmotic-pumps-or-direct-muscular-injection-enhances-aging-rat-laryngeal-muscles
#20
Richard D Andreatta, Joseph C Stemple, Tanya S Seward, Colleen A McMullen
Laryngeal dysfunction in the elderly is a major cause of disability, from voice disorders to dysphagia and loss of airway protective reflexes. Few, if any, therapies exist that target age-related laryngeal muscle dysfunction. Neurotrophins are involved in muscle innervation and differentiation of neuromuscular junctions (NMJs). It is thought that neurotrophins enhance neuromuscular transmission by increasing neurotransmitter release. The neuromuscular junctions (NMJs) become smaller and less abundant in aging rat laryngeal muscles, with evidence of functional denervation...
June 13, 2017: Journal of Visualized Experiments: JoVE
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