keyword
https://read.qxmd.com/read/38421436/the-effects-of-drug-drug-interaction-on-linezolid-pharmacokinetics-a-systematic-review
#21
REVIEW
Qiang Xu, Yanlei Sang, Anna Gao, Lu Li
OBJECTIVES: Linezolid is a commonly used antibiotic in the clinical treatment of gram-positive bacterial infections. The impacts of drug interactions on the pharmacokinetics of linezolid are often overlooked. This manuscript aims to review the medications that affect the pharmacokinetics of linezolid. METHODS: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we queried the PubMed, Embase, and Cochrane Library for publications from database establishment to November 3, 2023, using the search terms: "Linezolid" and "interaction," or "interact," or "drug-drug interaction," or "co-treatment," or "cotreatment," or "combined," or "combination...
February 29, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38416280/amiodarone-and-dronedarone-causes-liver-injury-with-distinctly-different-clinical-presentations
#22
JOURNAL ARTICLE
Alexander Pop, Dina Halegoua-DeMarzio, Huiman Barnhart, David Kleiner, Mark Avigan, Jiezhun Gu, Naga Chalasani, Jawad Ahmad, Robert J Fontana, William Lee, A Sidney Barritt, Francisco Durazo, Paul H Hayashi, Victor J Navarro
OBJECTIVE: To describe hepatotoxicity due to amiodarone and dronedarone from the DILIN and the US FDA's surveillance database. METHODS: Hepatotoxicity due to amiodarone and dronedarone enrolled in the U.S. Drug Induced Liver Injury Network (DILIN) from 2004 to 2020 are described. Dronedarone hepatotoxicity cases associated with liver biopsy results were obtained from the FDA Adverse Event Reporting System (FAERS) from 2009 to 2020. RESULTS: Among DILIN's 10 amiodarone and 3 dronedarone DILIN cases, the latency for amiodarone was longer than with dronedarone (388 vs 119 days, p = 0...
February 28, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38412657/the-priority-of-mesenchymal-stem-cells-treated-with-melatonin-in-ameliorating-thyroid-impairment-induced-by-amiodarone-thorough-look-on-the-apoptotic-pathway
#23
JOURNAL ARTICLE
Ehab A A El-Shaarawy, Soheir H Ahmed, Mogeda M Nasrallah, Ali K Mousa, Shereen Abdel Fattah
Amiodarone treatment has been associated with thyroid alterations. This work was planned to consider therapeutic outcome of MSCs versus MSCs treated with melatonin in minimizing amiodarone -induced deviations in thyroid. We handed-down 50 male Wistar rats, then distributed them into 5 groups; I, II, III, IV, V; control, sham control, amiodarone treated, amiodarone and MSCs treated, and amiodarone, MSCs and melatonin treated groups respectively. Light microscopic examination; levels of T3, T4 and TSH, Oxidative/antioxidative tissue markers, immune-histochemical staining (Bcl2, BAX, iNOS) and real time PCR (IL-6 and VEGF and Caspase 3) were done...
February 17, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38410427/hybrid-allosteric-modulators-of-m1-muscarinic-receptors-enhance-acetylcholine-efficacy-and-decrease-locomotor-activity-and-turning-behaviors-in-zebrafish
#24
Corey J Widman, Sestina Ventresca, Jillian Dietrich, Gwendolynne Elmslie, Hazel Smith, Gina Kaup, Aaron Wesley, Madeline Doenecke, Frederick E Williams, Isaac T Schiefer, John Ellis, William S Messer
Allosteric modulation of muscarinic acetylcholine receptors (mAChR) has been identified as a potential strategy for regulating cholinergic signaling in the treatment of various neurological disorders. Most positive allosteric modulators (PAMs) of mAChR enhance agonist affinity and potency, while very few PAMs selectively enhance G-protein coupling efficacy (e.g., amiodarone). The key structural features of amiodarone responsible for enhancement of mAChR efficacy were examined in CHO cells expressing M 1 receptors...
February 15, 2024: Research Square
https://read.qxmd.com/read/38403765/autopsy-of-drug-induced-lung-injury-with-atypical-diffuse-alveolar-disorder-due-to-amiodarone-a-case-report
#25
JOURNAL ARTICLE
Hikaru Mamizu, Hiroki Kohda, Yuusuke Tomita, Takuma Hatakeyama, Maiko Mamizu, Daisuke Ishikawa, Hidenori Kawakami, Toshiki Furukawa, Takashi Ishida, Tsuyoshi Sakai
Amiodarone, a prominent antiarrhythmic drug, may cause lung injury. We herein report the case of an 87-year-old man who had been taking amiodarone for 5 years and was subsequently referred due to respiratory failure. Chest computed tomography revealed multiple consolidations with air bronchograms in both lungs. Despite administering steroid pulse therapy, his respiratory failure worsened, and he died 3 days later. Autopsy revealed hyaline membrane formation and organic formation with fibrin deposition. Drug-induced lung injury caused by amiodarone was confirmed by autopsy...
February 26, 2024: Internal Medicine
https://read.qxmd.com/read/38392605/developing-a-model-for-quantifying-qtc-prolongation-risk-to-enhance-medication-safety-assessment-a-retrospective-analysis
#26
JOURNAL ARTICLE
Luis Giovannoni, Gerd A Kullak-Ublick, Alexander Jetter
There are currently no established methods to predict quantitatively whether the start of a drug with the potential to prolong the QTc interval poses patients at risk for relevant QTc prolongation. Therefore, this retrospective study aimed to pave the way for the development of models for estimating QTc prolongation in patients newly exposed to medications with QTc-prolonging potential. Data of patients with a documented QTc prolongation after initiation of a QTc-prolonging drug were extracted from hospital charts...
January 31, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38389933/the-phenomenon-of-phototoxicity-and-long-term-risks-of-commonly-prescribed-and-structurally-diverse-drugs
#27
JOURNAL ARTICLE
Anna E Davis, Gabrielle E Kennelley, Tatiana Amaye-Obu, Peter F Jowdy, Sarah Ghadersohi, Mehr Nasir-Moin, Gyorgy Paragh, Harvey A Berman, Wendy J Huss
Photosensitivity to structurally diverse drugs is a common but under-reported adverse cutaneous reaction and can be classified as phototoxic or photoallergic. Phototoxic reactions occur when the skin is exposed to sunlight after administering topical or systemic medications that exhibit photosensitizing activity. These reactions depend on the dose of medication, degree of exposure to ultraviolet light, type of ultraviolet light, and sufficient skin distribution volume. Accurate prediction of the incidence and phototoxic response severity is challenging due to a paucity of literature, suggesting that phototoxicity may be more frequent than reported...
February 2024: Journal of photochemistry and photobiology
https://read.qxmd.com/read/38385529/long-term-outcomes-of-the-pentaspline-pulsed-field-ablation-catheter-for-the-treatment-of-paroxysmal-atrial-fibrillation-results-of-the-prospective-multicenter-fara-freedom-study
#28
JOURNAL ARTICLE
Andreas Metzner, Martin Fiala, Johan Vijgen, Alexandre Ouss, Melanie Gunawardene, Jim Hansen, Josef Kautzner, Boris Schmidt, Mattias Duytschaever, Tobias Reichlin, Yuri Blaauw, Philipp Sommer, Annelies Vanderper, Anitha B Achyutha, Madeline Johnson, Jonathan D Raybuck, Petr Neuzil
INTRODUCTION/OBJECTIVES: Pulmonary vein isolation (PVI) is well-established strategy for the treatment of paroxysmal atrial fibrillation (PAF). Despite randomized controlled trials and real-world data showing the promise of pulsed-field ablation (PFA) for this treatment, long term efficacy and safety data demonstrating single procedure outcomes off antiarrhythmic drugs remain limited. The aim of the FARA-Freedom Study was to evaluate long-term efficacy and safety of PFA using the pentaspline catheter for PAF...
February 22, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/38383272/multidisciplinary-management-of-patients-with-chronic-obstructive-pulmonary-disease-and-cardiovascular-disease
#29
JOURNAL ARTICLE
Javier de Miguel-Díez, Julio Núñez Villota, Salud Santos Pérez, Nicolás Manito Lorite, Bernardino Alcázar Navarrete, Juan Francisco Delgado Jiménez, Juan José Soler-Cataluña, Domingo Pascual Figal, Patricia Sobradillo Ecenarro, Juan José Gómez Doblas
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently coexist, increasing the prevalence of both entities and impacting on symptoms and prognosis. CVD should be suspected in patients with COPD who have high/very high risk scores on validated scales, frequent exacerbations, precordial pain, disproportionate dyspnea, or palpitations. They should be referred to cardiology if they have palpitations of unknown cause or angina pain. COPD should be suspected in patients with CVD if they have recurrent bronchitis, cough and expectoration, or disproportionate dyspnea...
February 1, 2024: Archivos de Bronconeumología
https://read.qxmd.com/read/38372753/use-of-class-ic-antiarrhythmic-drugs-in-patients-with-structural-heart-disease-and-implantable-cardioverter-defibrillator
#30
JOURNAL ARTICLE
Maura M Zylla, Julian Wolfes, Ruben Schleberger, Dennis Lawin, Meinhard Kieser, Florian Reinke, Lars Eckardt, Andreas Rillig, Christoph Stellbrink, Dierk Thomas, Norbert Frey, Patrick Lugenbiel
BACKGROUND: Due to suspected pro-arrhythmic effects and increased mortality associated with class-IC antiarrhythmic drugs (AADs) in previous trials, AAD therapy in structural heart disease (SHD) is mainly restricted to amiodarone. In the presence of diagnostic and therapeutic advancements in cardiovascular medicine, it remains unclear if previous studies adequately reflect contemporary patients. In clinical practice, class-IC-AADs are occasionally used in individual cases, particularly in patients with an implantable cardioverter defibrillator (ICD)...
February 19, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38372622/the-outcomes-of-patients-with-septic-shock-treated-with-propafenone-compared-to-amiodarone-for-supraventricular-arrhythmias-are-related-to-end-systolic-left-atrial-volume
#31
JOURNAL ARTICLE
P Waldauf, M Porizka, J Horejsek, M Otahal, E Svobodova, I Jurisinova, M Maly, T Brozek, J Rulisek, P Trachta, T Tencer, A Krajcova, F Duska, M Balik
BACKGROUND: A recently published trial has shown no differences in outcomes between patients with new-onset supraventricular arrhythmia (SVA) in septic shock treated with either propafenone or amiodarone. However, these outcome data have not been evaluated in relation to the presence or absence of a dilated left atrium (LA). METHODS: Patients with SVA and a left ventricular ejection fraction ≥35% were randomized to receive intravenous propafenone (70mg bolus followed by 400-840mg/24h) or amiodarone (300mg bolus followed by 600-1800mg/24h)...
February 19, 2024: European Heart Journal. Acute Cardiovascular Care
https://read.qxmd.com/read/38361242/preoperative-amiodarone-and-primary-graft-dysfunction-in-heart-transplantation
#32
JOURNAL ARTICLE
Abigail Servais, Scott Lundgren, Stephanie Bowman, Douglas Stoller, Adam Burdorf, Marshall Hyden, Brian Lowes, Ronald Zolty, Don Klepser, Heidi Brink
BACKGROUND: Preoperative amiodarone effects on postorthotopic heart transplant (OHT) outcomes remain controversial. OBJECTIVE: The purpose of this study was to determine the effect of cumulative pre-OHT amiodarone exposure on severe primary graft dysfunction (PGD). METHODS: We retrospectively reviewed adult OHT recipients between August 2012 and June 2018. Primary outcome was severe PGD in patients receiving amiodarone at 3, 6, and 12 months prior to OHT compared with those not receiving amiodarone...
February 15, 2024: Annals of Pharmacotherapy
https://read.qxmd.com/read/38358408/interventions-to-prevent-postoperative-atrial-fibrillation-in-dutch-cardiothoracic-centres-a%C3%A2-survey-study
#33
JOURNAL ARTICLE
Angelique Emiola, Jolanda Kluin, Sulayman El Mathari, Joris R de Groot, Wim-Jan van Boven
INTRODUCTION: Postoperative atrial fibrillation (POAF) is a common phenomenon following cardiac surgery. In this study, we assessed current preventive strategies used by Dutch cardiothoracic centres, identified common views on this matter and related these to international guidelines. METHODS: We developed an online questionnaire and sent it to all cardiothoracic surgery centres in the Netherlands. The questionnaire concerned the management of POAF and the use of pharmaceutical therapies (beta-blockers and calcium antagonists) and non-pharmaceutical methods (posterior left pericardiotomy, pericardial flushing and epicardial botulinum toxin type A injections)...
February 15, 2024: Netherlands Heart Journal
https://read.qxmd.com/read/38353682/relevance-of-mexiletine-in-the-era-of-evolving-antiarrhythmic-therapy-of-ventricular-arrhythmias
#34
REVIEW
Nawar Alhourani, Julian Wolfes, Hilke Könemann, Christian Ellermann, Gerrit Frommeyer, Fatih Güner, Philipp Sebastian Lange, Florian Reinke, Julia Köbe, Lars Eckardt
Despite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias who require antiarrhythmic drug therapy and may, e.g., in otherwise drug and/or ablation refractory situations, benefit from agents known for decades, such as mexiletine. Through its capability of blocking fast sodium channels in cardiomyocytes, it has played a minor to moderate antiarrhythmic role throughout the recent decades. Nevertheless, certain patients with structural heart disease suffering from drug-refractory, i...
February 14, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38331386/using-bedside-spectral-doppler-ultrasound-for-the-assessment-of-patients-with-thyrotoxicosis
#35
JOURNAL ARTICLE
Michael Morkos, Karishma Datla Raju, Katherine Ibrahim
OBJECTIVE: To assess the bedside utility of spectral Doppler ultrasound (SDUS) in the initial evaluation of patients presenting with thyrotoxicosis. METHODS: This is a retrospective cross-sectional study of patients diagnosed with thyrotoxicosis at an academic outpatient endocrinology clinic from August 2019 to November 2022. The thyroid arteries' peak systolic velocities (PSV) were measured bilaterally using SDUS. PSV ≥40 cm/sec in at least a single thyroid artery was considered a reasonable cut-off for Graves' disease, and PSV of peri-nodular artery ≥ 25 cm/sec for toxic adenoma...
February 6, 2024: Endocrine Practice
https://read.qxmd.com/read/38327906/amiodarone-induced-leukocytoclastic-vasculitis-in-a-decompensated-heart-failure-patient-a-case-report
#36
Ummul Asfeen, Rohan Raj, Chinedu J Ezeafulukwe, Omar A Hassan, Deepa Treesa Francis, Sukhmeet S Dhillon, Aadil Khan
Leukocytoclastic vasculitis (LCV) is a small-vessel vasculitis characterized by inflammation and damage to the walls of small blood vessels. It typically presents with palpable purpura and can be associated with various systemic conditions. Although its etiology is diverse, LCV has been associated with systemic diseases, infections, medications, and autoimmune disorders. Here, we present a case of LCV in a patient with decompensated heart failure. A 58-year-old man presented with progressively deteriorating swelling in both his lower limbs and scrotum, a persistent dry cough associated with minor ulcerative lesions on his shins, and a patchy rash with pustules and flat reddish spots...
January 2024: Curēus
https://read.qxmd.com/read/38324103/safety-and-effectiveness-of-antidysrhythmic-drugs-for-pharmacologic-cardioversion-of-recent-onset-atrial-fibrillation-a-systematic-review-and-bayesian-network-meta-analysis
#37
REVIEW
Ian S deSouza, Pragati Shrestha, Robert Allen, Jessica Koos, Henry Thode
PURPOSE: The available evidence to determine which antidysrhythmic drug is superior for pharmacologic cardioversion of recent-onset (onset within 48 h) atrial fibrillation (AF) is uncertain. We aimed to identify the safest and most effective agent for pharmacologic cardioversion of recent-onset AF in the emergency department. METHODS: We searched MEDLINE, Embase, and Web of Science from inception to February 21, 2023 (PROSPERO: CRD42018083781). Eligible studies were randomized controlled trials that enrolled adult participants with AF ≤ 48 h, compared a guideline-recommended antidysrhythmic drug with another antidysrhythmic drug or a different formulation of the same drug or placebo and reported specific adverse events...
February 7, 2024: Cardiovascular Drugs and Therapy
https://read.qxmd.com/read/38321448/molecular-docking-as-a-tool-for-the-discovery-of-novel-insight-about-the-role-of-acid-sphingomyelinase-inhibitors-in-sars-cov-2-infectivity
#38
REVIEW
Samar Sami Alkafaas, Abanoub Mosaad Abdallah, Mai H Hassan, Aya Misbah Hussien, Sara Samy Elkafas, Samah A Loutfy, Abanoub Mikhail, Omnia G Murad, Mohamed I Elsalahaty, Mohamed Hessien, Rami M Elshazli, Fatimah A Alsaeed, Ahmed Ezzat Ahmed, Hani K Kamal, Wael Hafez, Mohamed T El-Saadony, Khaled A El-Tarabily, Soumya Ghosh
Recently, COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, caused > 6 million deaths. Symptoms included respiratory strain and complications, leading to severe pneumonia. SARS-CoV-2 attaches to the ACE-2 receptor of the host cell membrane to enter. Targeting the SARS-CoV-2 entry may effectively inhibit infection. Acid sphingomyelinase (ASMase) is a lysosomal protein that catalyzes the conversion of sphingolipid (sphingomyelin) to ceramide. Ceramide molecules aggregate/assemble on the plasma membrane to form "platforms" that facilitate the viral intake into the cell...
February 6, 2024: BMC Public Health
https://read.qxmd.com/read/38318252/prevalence-of-medication-associated-with-qtc-prolongation-used-among-critically-ill-patients
#39
JOURNAL ARTICLE
Ahmad Al-Azayzih, Walid Al-Qerem, Sayer Al-Azzam, Suhaib Muflih, Belal A Al-Husein, Zelal Kharaba, Roaa J Kanaan, Dania Rahhal
BACKGROUND: Acquired prolonged corrected QT (QTc) interval can lead to life-threatening Torsade de Pointes (TdP) arrhythmia. Multiple risk factors including medications, comorbidities, and electrolyte imbalances contribute significantly to acquired manifestations of the QTc prolongation. Critically ill patients are particularly more vulnerable to TdP due to complex medical conditions, aging, and polypharmacy. OBJECTIVE: This study aimed to assess the prevalence of TdP-associated medication prescribing, identify risk factors for QTc prolongation and TdP, and determine primary predictors of high TdP medication usage in critically ill patients in Jordan...
2024: Vascular Health and Risk Management
https://read.qxmd.com/read/38311991/-type-2-amiodarone-induced-thyrotoxicosis-efficacy-of-glucocorticoid-therapy-a-retrospective-analysis
#40
JOURNAL ARTICLE
A S Ermolaeva, V V Fadeev
BACKGROUND: Type 2 amiodarone-induced thyrotoxicosis remains a significant problem of endocrinology and cardiology. Due to the increase a life expectancy of the population, the prevalence of cardiac arrhythmias and prescribing of amiodarone are increasing. Thyrotoxicosis aggravates the existing cardiovascular disease in patients, leads to the progression of left ventricular dysfunction, relapses of arrhythmias, increasing the risk of adverse outcomes. The tactic of further management of patients is complicated: it is necessary to resolve the issue of canceling or continuing the use of antiarrhythmic drugs necessary for a patient with a history of cardiac arrhythmia, as well as competent therapy of the thyroid pathology that has arisen...
January 24, 2024: Problemy E̊ndokrinologii
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