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https://www.readbyqxmd.com/read/29786883/left-ventricular-aneurysms-in-hypertrophic-cardiomyopathy-with-midventricular-obstruction-a-systematic-review-of-literature
#1
Moustafa O Elsheshtawy, Ahmed N Mahmoud, Mahmoud Abdelghany, Ida H Suen, Adnan Sadiq, Jacob Shani
BACKGROUND: Hypertrophic cardiomyopathy (HCM) with or without left ventricular apical aneurysm (LVA) had been studied in the past. Midventricular obstruction associated with HCM and LVA is a unique entity that has not been distinguished previously as a separate phenotypic disease in HCM patients. METHODS: A systematic review of Pubmed and Google Scholar was conducted from inception until September 2017 for all observational studies conducted on HCM with midventricular obstruction and LVA...
May 22, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29781516/cardiac-autonomic-modulation-and-long-term-use-of-amiodarone-in-patients-with-chronic-chagasic-cardiopathy
#2
Henriette Elana Fortes Silva, Renan Sandoval de Almeida, Danilo Batista Silveira, Maurício Llaguno, Luiz Antônio Pertili Rodrigues Resende, Valdo José Dias da Silva, Dalmo Correia
BACKGROUND: Patients with chronic Chagas cardiopathy (CCC), which may be associated with cardiac arrhythmias, frequently use amiodarone, an anti-arrhythmic drug that, experimentally, appears to modulate the cardiac autonomic function. OBJECTIVE: The present cross-sectional observational study aimed to evaluate autonomic cardiac modulation in patients with CCC undergoing chronic amiodarone therapy. METHODS: Three groups were investigated: Group 1 included patients with CCC not treated with amiodarone (n = 27); Group 2 included patients with CCC with prolonged use (at least 6 months) of amiodarone (n = 16); and Group 3 including non-chagasic control patients (n = 23)...
May 21, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29764755/investigations-on-small-molecule-inhibitors-targeting-the-histone-h3k4-tri-methyllysine-binding-phd-finger-of-jmjc-histone-demethylases
#3
REVIEW
Bhaskar Bhushan, Alexandre Erdmann, Yijia Zhang, Roman Belle, Catrine Johannson, Udo Oppermann, Richard J Hopkinson, Christopher J Schofield, Akane Kawamura
Plant homeodomain (PHD) containing proteins are important epigenetic regulators and are of interest as potential drug targets. Inspired by the amiodarone derivatives reported to inhibit the PHD finger 3 of KDM5A (KDM5A(PHD3)), a set of compounds were synthesised. Amiodarone and its derivatives were observed to weakly disrupt the interactions of a histone H3K4me3 peptide with KDM5A(PHD3). Selected amiodarone derivatives inhibited catalysis of KDM5A, but in a PHD-finger independent manner. Amiodarone derivatives also bind to H3K4me3-binding PHD-fingers from the KDM7 subfamily...
March 19, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29762678/using-statistical-anomaly-detection-models-to-find-clinical-decision-support-malfunctions
#4
Soumi Ray, Dustin S McEvoy, Skye Aaron, Thu-Trang Hickman, Adam Wright
Objective: Malfunctions in Clinical Decision Support (CDS) systems occur due to a multitude of reasons, and often go unnoticed, leading to potentially poor outcomes. Our goal was to identify malfunctions within CDS systems. Methods: We evaluated 6 anomaly detection models: (1) Poisson Changepoint Model, (2) Autoregressive Integrated Moving Average (ARIMA) Model, (3) Hierarchical Divisive Changepoint (HDC) Model, (4) Bayesian Changepoint Model, (5) Seasonal Hybrid Extreme Studentized Deviate (SHESD) Model, and (6) E-Divisive with Median (EDM) Model and characterized their ability to find known anomalies...
May 11, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29753379/the-antiarrhythmic-drug-amiodarone-decreases-akt-activity-and-sensitizes-human-acute-myeloid-leukemia-cells-to-apoptosis-by-abt-263
#5
Corey J Ketchem, Cory Kucera, Aditya Barve, Levi J Beverly
BACKGROUND: Successful treatment of leukemia requires new medications to combat drug resistance, but the development of novel therapies is an arduous and risky endeavor. Repurposing currently approved drugs or those already in clinical development to treat other indications is a more practical approach. Moreover, combinatorial therapeutics are often more efficacious than single agent therapeutics because the former can simultaneously target multiple pathways that mitigate tumor aggressiveness and induce cancer cell death...
May 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29750121/-in-vivo-confocal-microscopic-observations-of-vortex-keratopathy-in-patients-with-amiodarone-induced-keratopathy-and-fabry-disease
#6
Yasuhito Ikegawa, Atsushi Shiraishi, Yasuhito Hayashi, Akiyoshi Ogimoto, Yuichi Ohashi
Purpose: To compare the morphology of two types of vortex keratopathy: amiodarone-induced keratopathy and the Fabry disease-associated keratopathy. Patients and Methods: Eight patients who were receiving oral amiodarone therapy and 3 patients with Fabry disease, a mother and her 2 daughters, were examined by slit-lamp biomicroscopy and in vivo confocal microscopy (IVCM) regularly. Results: Amiodarone-induced keratopathy developed in 7 of the 8 patients, and it was detected as early as 7 days by IVCM and 14 days by slit-lamp biomicroscopy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29748197/minimally-invasive-delivery-of-hydrogel-encapsulated-amiodarone-to-the-epicardium-reduces-atrial-fibrillation
#7
Jose R Garcia, Peter F Campbell, Gautam Kumar, Jonathan J Langberg, Liliana Cesar, Juline N Deppen, Eric Y Shin, Neal K Bhatia, Lanfang Wang, Kai Xu, Frank Schneider, Brian Robinson, Andrés J García, Rebecca D Levit
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Although treatment options for AF exist, many patients cannot be maintained in normal sinus rhythm. Amiodarone is an effective medication for AF but has limited clinical utility because of off-target tissue toxicity. METHODS: Here, we use a pig model of AF to test the efficacy of an amiodarone-containing polyethylene glycol-based hydrogel. The gel is placed directly on the atrial epicardium through the pericardial space in a minimally invasive procedure using a specially designed catheter...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29743186/amiodarone-induced-hepatic-and-pulmonary-toxicity
#8
Li-Ta Keng, Min-Tsun Liao
No abstract text is available yet for this article.
May 9, 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29740314/effect-of-toxicants-on-fatty-acid-metabolism-in-hepg2-cells
#9
David Grünig, Urs Duthaler, Stephan Krähenbühl
Impairment of hepatic fatty acid metabolism can lead to liver steatosis and injury. Testing drugs for interference with hepatic fatty acid metabolism is therefore important. To find out whether HepG2 cells are suitable for this purpose, we investigated the effect of three established fatty acid metabolism inhibitors and of three test compounds on triglyceride accumulation, palmitate metabolism, the acylcarnitine pool and dicarboxylic acid accumulation in the cell supernatant and on ApoB-100 excretion in HepG2 cells...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29736963/biomimetic-synthesis-of-drug-metabolites-in-batch-and-continuous-flow-reactors
#10
Tamás Fődi, Gergő Ignácz, Balázs Decsi, Zoltán Béni, György István Túrós, József Kupai, Diána Balogh-Weiser, István Greiner, Péter Huszthy, György Tibor Balogh
A Medium Throughput Screening (MTS) for iron porphyrin catalyst based biomimetic drug metabolite synthesis is developed. The microplate based method in combination with HPLC-MS analysis was shown to be a useful tool for process development and parameter optimization in the production of targeted metabolites and/or oxidation products of forty-three different drug substances. In case of biomimetic oxidation of amiodarone, quantity and purity of the isolated products enabled detailed HRMS and NMR spectroscopic studies...
May 8, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29736825/bleeding-events-attributable-to-concurrent-use-of-warfarin-and-other-medications-in-high-risk-elderly-meta-analysis-and-italian-population-based-investigation
#11
Rosanna Irene Comoretto, Federico Rea, Ersilia Lucenteforte, Alessandro Mugelli, Gianluca Trifirò, Silvia Cascini, Giuseppe Roberto, Alessandro Chinellato, Amelia Filippelli, Giovanni Corrao
PURPOSE: The aim of this study was to estimate the proportion of bleedings that occurred among warfarin users attributable to the concomitant use of other medications. A general approach for measuring the impact of the prescriptive inappropriateness on drug adverse outcomes at the population level is described. METHODS: A meta-analysis was conducted to obtain summary relative risks of bleeding associated with concurrent use of warfarin and other medications compared to warfarin use alone...
May 7, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29735493/recurrent-blistering-distal-dactylitis-due-to-staphylococcus-aureus-in-an-immunocompetent-elderly-woman
#12
Colin A Hinkamp, Nikhil H Shah, Neal Holland, Ashleigh Wright
An 86-year-old woman presented with marked blistering of her left index fingertip and ulceration of the left middle fingertip, with a 2-year history of recurrent blistering and ulceration of her fingers bilaterally. She denied any preceding finger trauma, although she reported frequent gardening. She denied systemic symptoms. Her medical history was significant for a 2-year history of atrial fibrillation on carvedilol, amiodarone and apixaban, and she was a lifetime non-smoker. On admission, she had elevated inflammatory markers but unremarkable autoantibodies...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29734517/rosuvastatin-induced-rhabdomyolysis-possible-role-of-ticagrelor-and-patients-pharmacogenetic-profile
#13
Majda Vrkić Kirhmajer, Viola Macolić Šarinić, Livija Šimičević, Iva Ladić, Krešimir Putarek, Ljiljana Banfić, Nada Božina
Up to the beginning of 2018, a total of eight cases describing rare but clinically important drug interactions between rosuvastatin and ticagrelor which resulted in rhabdomyolysis have been noted in the Global World Health Organization (WHO) adverse drug reaction (ADR) database (VigiBase) as well as in available literature. There are several possible factors which could contribute to the onset of rhabdomyolysis: old age, initially excessive rosuvastatin dose, drug-drug interactions (DDI) on metabolic enzymes (CYPs and UGTs) and drug transporter levels (ABCB1, ABCG2, OATP1B1) and pharmacogenetic predisposition...
May 7, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29701361/postoperative-atrial-fibrillation-after-coronary-artery-bypass-grafting-surgery
#14
Ana Filipa Ferreira, Francisca A Saraiva, Raquel Moreira, Rui J Cerqueira, Mário J Amorim, Paulo Pinho, André P Lourenço, Adelino F Leite-Moreira
INTRODUCTION: Postoperative atrial fibrillation (PoAF) is the most common arrhythmia following cardiac surgery, which increase the patient's morbidity and mortality. PURPOSE: The aim of this study was to evaluate new onset of atrial fibrillation (AF) after isolated coronary artery bypass grafting (CABG) surgery, its clinical and surgical predictors, and its impact in immediate and long-term outcomes. METHODS: Retrospective study including all CABG surgeries performed in a tertiary centre, between 2004 and 2011...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29699616/propranolol-versus-metoprolol-for-treatment-of-electrical-storm-in-patients-with-implantable-cardioverter-defibrillator
#15
Sofia Chatzidou, Christos Kontogiannis, Diamantis I Tsilimigras, Georgios Georgiopoulos, Marinos Kosmopoulos, Elektra Papadopoulou, Georgios Vasilopoulos, Stylianos Rokas
BACKGROUND: Electrical storm (ES), characterized by unrelenting recurrences of ventricular arrhythmias, is observed in approximately 30% of patients with implantable cardioverter-defibrillators (ICDs) and is associated with high mortality rates. OBJECTIVES: Sympathetic blockade with β-blockers, usually in combination with intravenous (IV) amiodarone, have proved highly effective in the suppression of ES. In this study, we compared the efficacy of a nonselective β-blocker (propranolol) versus a β1 -selective blocker (metoprolol) in the management of ES...
May 1, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29689189/emerging-role-of-amiodarone-and-dronedarone-as-antiarrhythmic-drugs-in-treatment-of-leishmaniasis
#16
REVIEW
A Oryan, E Bemani, S Bahrami
Leishmaniasis is a group of human and animal diseases causing 20,000 to 40,000 annual deaths and its etiological agents belong to the Leishmania genus. The most current treatment against leishmaniasis is chemotherapy. Pentavalent antimonials such as glucantime and pentostam have been administrated as the first-line drugs in treatment of various forms of leishmaniasis. The second-line drugs such as amphotericin B, liposomal amphotericin B, miltefosine, pentamidine, azole drugs and paromomycin are used in resistant cases to pentavalent antimonials...
April 21, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29687867/cryoablation-for-atrial-fibrillation-and-antiarrhythmic-drug-pretreatment-a-single-referral-center-experience
#17
M Spartalis, E Tzatzaki, E Spartalis, D Moris, I Doulamis, A S Triantafyllis, E Livanis, G Theodorakis
OBJECTIVE: Pulmonary vein isolation (PVI) ablation has emerged as the gold standard of ablative strategies to treat medically refractory paroxysmal and persistent atrial fibrillation (AF). Regardless of the superiority of catheter ablation based on PVI over antiarrhythmic drug therapy, recurrence rates of AF remain higher than desired. PVI via cryoablation has rapidly become a mainstream treatment for AF, due to its effectiveness and fast learning curve. Our objective was to assess the safety and efficacy of cryoablation in a single referral center...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29684665/anti-trypanosoma-cruzi-action-of-a-new-benzofuran-derivative-based-on-amiodarone-structure
#18
Andrea Pinto-Martinez, Vanessa Hernández-Rodríguez, Jessica Rodríguez-Durán, Elżbieta Hejchman, Gustavo Benaim
Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi. There is no current effective treatment since the only two available drugs have a limited efficacy and produce side effects. Thus, investigation efforts have been directed to the identification of new drug leads. In this context, Ca2+ regulating mechanisms have been postulated as targets for antiparasitic compounds, since they present paramount differences when compared to host cells. Amiodarone is an antiarrhythmic with demonstrated trypanocidal activity acting through the disruption of the parasite intracellular Ca2+ homeostasis...
April 11, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29675679/adsorption-and-leachable-contamination-of-flucloxacillin-cyclosporin-and-amiodarone-following-delivery-through-an-intravenous-administration-set
#19
Zachary Woodward, Peter Brooks, Bernadette Morris-Smith, Marianne Wallis, Steven M Ogbourne
PURPOSE: Interactions between a pharmaceutical drug and its delivery device can result in changes in drug concentration and leachable contamination. Flucloxacillin, amiodarone and cyclosporin were investigated for drug concentration changes and leachable contamination after delivery through an intravenous administration set. METHODS: Flucloxacillin, amiodarone and cyclosporin were delivered through an intravenous administration set and the eluate analysed by HPLC-UV and HPLC-MS...
April 19, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29668588/a-delayed-diagnosis-of-catecholaminergic-polymorphic-ventricular-tachycardia-with-a-mutant-of-ryr2-at-c-7580t-g-for-6-years-in-a-9-year-old-child
#20
Hongyu Duan, Yongyi Lu, Song Yan, Lina Qiao, Yimin Hua, Yifei Li, Kaiyu Zhou, Chuan Wang
RATIONALE: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but potentially lethal inherited arrhythmia syndrome induced by adrenergic stress. Due to the atypical clinical manifestations in early age, limited recognition and experience of pediatric cardiologists, and low awareness of the significance of genetic diagnosis in some underdeveloped areas in China, a delayed or missed diagnosis of CPVT in children is common and concerning. PATIENT CONCERNS: A 9-year and 3-month male child with recurrent exercise-induced syncope accompanied by convulsion was initially misdiagnosed as epilepsy since the first manifestation at the age of 3 years...
April 2018: Medicine (Baltimore)
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