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https://www.readbyqxmd.com/read/29678403/tick-borne-encephalitis-virus-borrelia-burgdorferi-sensu-lato-borrelia-miyamotoi-anaplasma-phagocytophilum-and-candidatus-neoehrlichia-mikurensis-in-ixodes-ricinus-ticks-collected-from-recreational-islands-in-southern-norway
#1
Vivian Kjelland, Katrine M Paulsen, Rikke Rollum, Andrew Jenkins, Snorre Stuen, Arnulf Soleng, Kristin S Edgar, Heidi H Lindstedt, Kirsti Vaino, Moustafa Gibory, Åshild K Andreassen
The aim of this study was to determine the occurrence of tick-borne pathogens of medical importance in questing ticks collected from five recreationally used islands along the Norwegian coastline. Furthermore, since coinfection may affect the disease severity, this study aimed to determine the extent of coinfection in individual ticks or co-localization of tick-borne pathogens. In all, 4158 questing Ixodes ricinus ticks were analyzed. For detection of tick-borne encephalitis virus (TBEV), nymphs (3690) were analyzed in pools of ten...
April 12, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29677205/anemia-in-tuberculosis-cases-and-household-controls-from-tanzania-contribution-of-disease-coinfections-and-the-role-of-hepcidin
#2
Jerry Hella, Colin I Cercamondi, Francis Mhimbira, Mohamed Sasamalo, Nicole Stoffel, Marcel Zwahlen, Thomas Bodmer, Sebastien Gagneux, Klaus Reither, Michael B Zimmermann, Lorenz Risch, Lukas Fenner
BACKGROUND: Tuberculosis (TB) induces a systemic inflammatory state affecting iron homeostasis. Patients with TB often have additional comorbidities such as anemia which can result in poorer treat outcomes. We studied the contribution of anemia and the role of the iron regulatory hormone hepcidin among TB patients and household contacts. METHODS: We analyzed serum samples from 102 TB cases and 98 controls without TB, matched by age/sex, for hepcidin, iron, and inflammation parameters...
2018: PloS One
https://www.readbyqxmd.com/read/29676935/current-and-emerging-two-drug-approaches-for-hiv-1-therapy-in-art-na%C3%A3-ve-and-art-experienced-virologically-suppressed-patients
#3
Barbara Rossetti, Francesca Montagnani, Andrea De Luca
Current guidelines recommend a 2-drug antiretroviral regimen as an alternative to triple antiretroviral therapy (ART) in selected patients to reduce long-term toxicity and costs. Areas covered: This review is intended to provide insight into the efficacy, safety and tolerability of 2-drug versus 3-drug ART in naïve and in treatment-experienced virologically-suppressed patients. Expert opinion: Dual therapy regimens are not feasible in HBV-coinfected individuals and should not be applied during pregnancy. Positive data on 2-drug ART in drug naïve patients are still limited, while, in virologically-suppressed individuals, several regimens have shown non-inferiority as compared to 3-drug regimens...
April 20, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29673810/a-systematic-review-of-emerging-respiratory-viruses-at-the-hajj-and-possible-coinfection-with-streptococcus-pneumoniae
#4
REVIEW
Jaffar A Al-Tawfiq, Samir Benkouiten, Ziad A Memish
BACKGROUND: The annual Hajj to the Kingdom of Saudi Arabia attracts millions of pilgrims from around the world. International health community's attention goes towards this mass gathering and the possibility of the development of any respiratory tract infections due to the high risk of acquisition of respiratory viruses. METHOD: We searched MEDLINE/PubMed and Scopus databases for relevant papers describing the prevalence of respiratory viruses among Hajj pilgrims...
April 16, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29670780/syphilis-related-eye-disease-presenting-as-bilateral-papilledema-retinal-nerve-fiber-layer-hemorrhage-and-anterior-uveitis-in-a-penicillin-allergic-patient
#5
Jamie Dietze, Shane Havens
Purpose . Treponema pallidum is known as the "great masquerader" for its many presentations and ocular findings in patients who are infected and develop secondary and tertiary stage of syphilis. Syphilitic ocular manifestations include uveitis, chorioretinitis, retinitis, vasculitis, vitritis, and panuveitis all with or without decreased visual acuity. Human immunodeficiency virus (HIV) is known to expedite the progression of syphilis when patients are coinfected, thus compounding the potential ophthalmic presentations...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29668109/coevolution-of-virulence-and-immunosuppression-in-multiple-infections
#6
Tsukushi Kamiya, Nicole Mideo, Samuel Alizon
Many components of host-parasite interactions have been shown to affect the way virulence (i.e., parasite-induced harm to the host) evolves. However, coevolution of multiple parasite traits is often neglected. We explore how an immunosuppressive mechanism of parasites affects and coevolves with virulence through multiple infections. Applying the adaptive dynamics framework to epidemiological models with coinfection, we show that immunosuppression is a double-edgedsword for the evolution of virulence. On one hand, it amplifies the adaptive benefit of virulence by increasing the abundance of coinfections through epidemiological feedbacks...
April 18, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29668077/jc-and-bk-virus-dna-detection-in-archival-slides-of-urine-cytospin-from-renal-transplant-patients
#7
Patricia Assis, Carlos Eduardo Carvalho, Marcelo Soares Silva, Bruna Ribeiro, Maria da Gloria Carvalho
BACKGROUND: Although identifying cytological viral inclusions (decoy cells) in the urine is relatively easy, distinguishing between Polyomaviruses BKV and JCV is not possible. Few studies have been published regarding JCV detection in kidney transplant recipients. OBJECTIVE: To evaluate the incidence of BKV and JCV DNA in archival slides of urine cytospin material from renal transplant patients. METHODS: A total of 44 urine specimens were evaluated cytologically for the presence of viral inclusions (decoy cells) and by nested polymerase chain reaction to differentiate between JCV and BKV in DNA isolated from archival slides of urine cytospin material...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29666702/an-evaluation-of-treatment-outcomes-in-a-cohort-of-clients-on-the-dots-strategy-2012-2016
#8
Ato Kwamena Tetteh, Edward Agyarko, Joseph Otchere, Langbong Bimi, Irene Ayi
We present, for the first time, an evaluation of treatment outcomes in a cohort at a TB referral centre in the Central Region of Ghana. Of the 213 clients placed on DOTS, 59.2% (126/213) were sputum smear-positive. An overall cure rate of 90.2% (51.6% cured + 37.6% completed) and a death rate of 8.5% (18/213) were estimated. Of the number of clients who died, 5.7% (12/213) were males ( χ 2 = 2.891, p = 0.699; LR = 3.004, p = 0.699). Deaths were only recorded among clients who were > 19 years old ( χ 2 = 40...
2018: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/29666698/prevalence-of-intestinal-parasites-and-associated-factors-among-pulmonary-tuberculosis-suspected-patients-attending-university-of-gondar-hospital-gondar-northwest-ethiopia
#9
Yalewayker Tegegne, Tadelo Wondmagegn, Ligabaw Worku, Ayalew Jejaw Zeleke
Introduction: Intestinal parasitic infections are among the major public health problems in developing countries. Hence, it is significant to explore coinfection with intestinal parasites and pulmonary tuberculosis because coinfection increases the complexity of control and prevention of pulmonary tuberculosis and parasitic diseases. Objective: To assess the prevalence of intestinal parasites among pulmonary tuberculosis suspected patients. Method: Institutional based cross-sectional study was conducted at University of Gondar Hospital from March to May, 2017...
2018: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29665069/generic-velpatasvir-plus-sofosbuvir-for-hepatitis-c-virus-infection-in-patients-with-or-without-human-immunodeficiency-virus-coinfection
#10
C-H Liu, H-Y Sun, C-J Liu, W-H Sheng, S-M Hsieh, Y-C Lo, W-C Liu, T-H Su, H-C Yang, C-M Hong, T-C Tseng, P-J Chen, D-S Chen, C-C Hung, J-H Kao
BACKGROUND: Data are limited regarding the effectiveness and safety of generic velpatasvir plus sofosbuvir (VEL/SOF) for hepatitis C virus (HCV) in patients with or without human immunodeficiency virus (HIV) coinfection. AIM: To evaluate the effectiveness and safety of generic VEL/SOF-based therapy for HCV infection in patients with or without HIV coinfection in Taiwan. METHODS: Sixty-nine HIV/HCV-coinfected and 159 HCV-monoinfected patients receiving 12 weeks of generic VEL/SOF with or without ribavirin (RBV) for HCV were prospectively enrolled...
April 17, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29664990/schistosomiasis-and-hydration-status-schistosoma-haematobium-but-not-schistosoma-mansoni-increases-urine-specific-gravity-among-rural-tanzanian-women
#11
Asher Y Rosinger, Sera L Young, Shalean M Collins, Syeda Razia Haider, Pallavi Mishra, Honest T Nagai, Mnyeshi Petro, Jennifer A Downs
OBJECTIVES: Schistosome infections can damage organs important for water homeostasis, especially the kidneys. Urogenital schistosomiasis (caused by Schistosoma haematobium) increases protein and blood in urine and intestinal schistosomiasis (caused by S. mansoni) affects total body water. However, no data exist on how different schistosome species affect urine specific gravity (USG), a hydration biomarker. Therefore, we assessed the relationship between S. haematobium- and S. mansoni-infected and uninfected women and USG in rural Tanzania...
April 17, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29664772/adenovirus-ocular-infections-prevalence-pathology-pitfalls-and-practical-pointers
#12
Debora Garcia-Zalisnak, Christopher Rapuano, John D Sheppard, Andrew R Davis
Adenoviral conjunctivitis comprises a large number of physician office visits in the United States and places a great financial burden on health care. It is estimated that the incidence of adenovirus infection to be as high as 20 million cases per year in the United States. There are multiple adenovirus serotypes, each associated with different types and severity of infection. Ocular manifestations of adenovirus include epidemic keratoconjunctivitis, pharyngoconjunctival fever, and nonspecific conjunctivitis...
April 13, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29663447/evolution-of-hbv-s-gene-in-the-backdrop-of-hdv-co-infection
#13
Samina Baig, Syed H Abidi, Zahid Azam, Shahid Majid, Saeed Khan, Muhammad R Khanani, Syed Ali
BACKGROUND: HBV-HDV co-infected people have a higher chance of developing cirrhosis, fulminant hepatitis, and hepatocellular carcinoma (HCC) compared to those infected only with HBV. OBJECTIVE: The present study was conducted to investigate HBV genotypes and phylogeny among HBV mono-infected and HBV-HDV co-infected patients, as well as analyze mutations in the surface gene of HBV in mono-infected and co-infected patients. METHODS: A total of 100 blood samples (50 co-infected with HBV and HDV, and 50 mono-infected with HBV only) were collected for this study...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29660249/shorter-hbig-administration-is-not-associated-to-hbv-recurrence-when-receiving-combined-prophylaxis-after-liver-transplantation
#14
Sabela Lens, María García-Eliz, Inmaculada Fernández, Lluis Castells, Martin Bonacci, Antoni Mas, Gonzalo Crespo, María Buti, Martín Prieto, Xavier Forns
BACKGROUND AND AIM: The combination of hepatitis B immunoglobulin (HBIG) and a nucleos(t)ide analogs (NA) has markedly reduced the rate of hepatitis B (HBV) recurrence after liver transplantation (LT); however, the optimal duration of HBIG has not been clarified. This lack of consensus perpetuates the use of different strategies. The aim of this study was to evaluate the risk factors associated to HBV recurrence after LT in a large cohort of patients under different HBIG regimens. METHODS: Retrospective multicenter analysis of HBV-related LT recipients receiving combined prophylaxis (HBIG+NA)...
April 16, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29659904/coinfection-with-zika-and-dengue-viruses-results-in-preferential-zika-transmission-by-vector-bite-to-vertebrate-host
#15
Barbara Aparecida Chaves, Alessandra Silva Orfano, Paula Monalisa Nogueira, Nilton Barnabe Rodrigues, Thais Bonifácio Campolina, Rafael Nacif-Pimenta, Ana Clara Araújo Machado Pires, Ademir Bentes Vieira Júnior, Andréia da Costa Paz, Evelyn Beatriz da Costa Vaz, Maria das Graças Vale Barbosa Guerra, Breno Melo Silva, Fabrício Freire de Melo, Douglas Eric Norris, Marcus Vinícius Guimarães de Lacerda, Paulo Filemon Paolucci Pimenta, Nágila Francinete Costa Secundino
Background: Several tropical cities are permissive to Aedes aegypti and DENV endemicity, and have allowed for invasion and circulation of ZIKV in the same areas. People living in endemic regions have been simultaneously infected with two or more arboviruses. Methods: Ae. aegypti mosquitoes from Manaus, capital city of the Amazonas State, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results: Ae...
April 6, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29659859/seroprevalence-of-toxoplasma-gondii-and-neospora-caninum-infection-in-sheep-goats-and-fallow-deer-farmed-on-the-same-area
#16
Bozena Moskwa, Aleksandra Kornacka, Aleksandra Cybulska, Wladyslaw Cabaj, Katarina Reiterova, Marek Bogdaszewski, Zaneta Steiner-Bogdaszewska, Justyna Bien
Toxoplasma gondii and Neospora caninum are coccidian parasites with a global distribution that cause reproductive failure and production losses in livestock. The seroprevalence of both parasite species in ruminants and Cervidae has been investigated worldwide and found to vary greatly.Studies carried out on mixed flocks with three ruminant species (sheep, goats and fallow deer) living under the same conditions are excellent models for identifying any differences in the rate of infection with the two parasites between the animal species...
April 6, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29659605/chronic-kidney-disease-in-the-global-adult-hiv-infected-population-a-systematic-review-and-meta-analysis
#17
Udeme E Ekrikpo, Andre P Kengne, Aminu K Bello, Emmanuel E Effa, Jean Jacques Noubiap, Babatunde L Salako, Brian L Rayner, Giuseppe Remuzzi, Ikechi G Okpechi
INTRODUCTION: The widespread use of antiretroviral therapies (ART) has increased life expectancy in HIV patients, predisposing them to chronic non-communicable diseases including Chronic Kidney Disease (CKD). We performed a systematic review and meta-analysis (PROSPERO registration number CRD42016036246) to determine the global and regional prevalence of CKD in HIV patients. METHODS: We searched PubMed, Web of Science, EBSCO and AJOL for articles published between January 1982 and May 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29657373/severe-varicella-pneumonia-in-adults-seven-years-single-center-experience-from-india
#18
Akashdeep Singh, Siddharth Parkash, Sunil K Gupta, R K Soni
Context: Varicella pneumonia is a rare but a serious complication of chickenpox in adults. There is paucity of data on varicella pneumonia from India. Aims: The aim of this study is to describe the clinical manifestations, hospital course, treatment, and outcome of adult patients with severe varicella pneumonia. Settings and Design: This was a retrospective, observational study of patients with severe varicella pneumonia attending a tertiary care teaching hospital...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29652971/-factors-associated-to-survival-in-patients-with-hiv-tb-in-the-department-of-infectious-diseases-of-the-arzobispo-loayza-national-hospital-per%C3%A3%C2%BA-since-2004-to-2012
#19
Brenda Gamboa-Acuña, Rayza Guillén-Zambrano, Grecia Lizzetti-Mendoza, Alonso Soto, Aldo Lucchetti-Rodríguez
Background The main cause of death in HIV patients is tuberculosis (TB). However, few Latin American studies have evaluated the prognosis of patients with coinfection. Aim To determine the factors associated with survival in patients with HIV-TB coinfection treated at a Peruvian referral hospital. Methods A retrospective cohort study was performed based on clinical records of patients treated at the Department of Infectious Diseases in the Arzobispo Loayza National Hospital from 2004 to 2012. Survival was assessed using the Kaplan-Meier estimator and Cox Proportional Hazard Model...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29652804/cerebrospinal-fluid-concentrations-of-biogenic-amines-potential-biomarkers-for-diagnosis-of-bacterial-and-viral-meningitis
#20
Aneela Taj, Nusrat Jamil
Catecholamine and serotonin are biogenic amines (BAs) that serve as neurotransmitters and play an important role in the regulation of cardinal functions that are mainly altered during central nervous system (CNS) infections. A total 92 samples of cerebrospinal fluid (CSF) were classified into 4 groups based on their etiology. In these samples, BAs/neurotransmitters i.e., dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5HIAA) were detected and quantified by high performance liquid chromatography with electrochemical detection (HPLC-EC) to determine the neurophysiology of the CNS infections by bacteria ( Listeria monocytogenes (Lm) and Neisseria meningitidis (Nm)) and herpes simplex virus (HSV)...
April 13, 2018: Pathogens
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