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https://www.readbyqxmd.com/read/27911694/seroprevalence-of-babesia-microti-in-individuals-with-lyme-disease
#1
Sabino R Curcio, Laurel P Tria, Azad L Gucwa
INTRODUCTION: Babesiosis is an emerging tick-borne disease (TBD) caused by Babesia microti, an intracellular parasite of red blood cells. Currently, it is the highest ranked pathogen transmitted by blood transfusion. Most healthy individuals infected with B. microti are asymptomatic, but may be at risk for chronic infection. Similar to Lyme disease transmitted by Borrelia burgdorferi, B. microti is spread by Ixodes scapularis ticks. The rate of coinfection with these TBDs in humans is unclear as most studies have focused their prevalence in ticks or rodent reservoirs...
December 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27910154/interferon-free-regimens-improve-portal-hypertension-and-histological-necroinflammation-in-hiv-hcv-patients-with-advanced-liver-disease
#2
P Schwabl, M Mandorfer, S Steiner, B Scheiner, D Chromy, M Herac, T Bucsics, H Hayden, K Grabmeier-Pfistershammer, A Ferlitsch, G Oberhuber, M Trauner, M Peck-Radosavljevic, T Reiberger
BACKGROUND: HIV/HCV co-infected patients show accelerated fibrosis progression and higher risk for complications of portal hypertension (PHT). AIM: To assess the effects of interferon-free therapy on portal pressure, liver histology and plasma biomarkers in HIV/HCV-coinfected patients with PHT. METHODS: Twenty-two patients with paired hepatic venous pressure gradient (HVPG) measurements prior and after successful treatment (SVR) with interferon-free regimens were included...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27906011/prevalence-of-hiv-and-hepatitis-b-coinfection-in-ghana-a-systematic-review-and-meta-analysis
#3
REVIEW
Akosua Adom Agyeman, Richard Ofori-Asenso
BACKGROUND: Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) coinfection has been associated with higher morbidity and mortality and may impact significantly on healthcare resource utilization. However, in Ghana, accurate estimates of the prevalence of HIV/HBV coinfection needed to inform policy decisions and the design of public health interventions are currently lacking. In this study, our aim was to determine the HIV/HBV coinfection prevalence rate in Ghana. METHODS: Primary studies reporting prevalence of HIV/HBV coinfection in Ghana were retrieved through searches conducted in PubMed, science direct, Google scholar and Africa journals online (AJOL) databases...
May 17, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905632/-co-infection-by-chikungunya-virus-chik-v-and-dengue-virus-den-v-during-a-recent-outbreak-in-cali-colombia-report-of-a-fatal-case
#4
Fernando Rosso, Robinson Pacheco, Sarita Rodríguez, Diego Bautista
The recent outbreaks of Chikungunya (CHIK-V) virus in endemic areas of dengue (DEN-V) could increase the risk of co-infection. CHIK infection has been considered not severe and with very unusual mortality, however DEN is associated with severe manifestations and increased mortality. Little is known about coinfection. It is possible that co-infection could generate severe cases. We present a case report of co-infection DEN-V -3 and CHIK-V in an elderly patient who developed acute renal failure, dengue shock syndrome (DSS), progresses to multiple organ failure and died...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27903948/characterizing-patients-with-very-low-level-hiv-viremia-a-community-based-study
#5
Elie Helou, Sheela Shenoi, Tassos Kyriakides, Marie-Louise Landry, Michael Kozal, Lydia Aoun Barakat
OBJECTIVE: Very-low-level viremia (VLLV) is a relatively new concept in the realm of human immunodeficiency virus (HIV) care. Newer generation assays are now able to detect plasma HIV RNA Viral Load (VL) levels as low as 20 copies/mL. The authors characterized patients with VLLV (VL between 20 and 50 copies/mL) in order to identify possible risk factors associated with virologic failure and poor clinical outcomes. METHODS: The authors reviewed 119 consecutive charts of patients with VLLV...
November 30, 2016: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/27902903/characterization-of-thai-mycoplasma-synoviae-isolates-by-sequence-analysis-of-partial-vlha-gene
#6
Kriengwich Limpavithayakul, Jiroj Sasipreeyajan, Somsak Pakpinyo
Mycoplasma synoviae (MS), a remarkable pathogen in poultry, causes subclinical infection of the upper respiratory tract and an infectious synovitis, especially in the tendon sheaths and synovial membranes of joints. Because the specific detection of MS 16S rRNA gene-based PCR was unsuitable for strain differentiation, vlhA gene-based PCR was designed to differentiate the MS strains. The vlhA gene of MS encodes for hemagglutinin and other immunodominant membrane proteins involved in colonization, antigenic variations, and virulence...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27898593/coinfection-with-hiv-and-hepatitis-c-virus-in-229-children-and-young-adults-living-in-europe
#7
(no author information available yet)
OBJECTIVE: To characterize children, adolescents and young adults infected with HIV/hepatitis C virus (HCV) vertically or before age of 18 years and living in Europe regarding mode of acquisition, HCV genotype, clinical status and treatment. DESIGN: Retrospective, cross-sectional study using pooled data from 11 European paediatric HIV cohorts. METHODS: Patients aged more than 18 months and less than 25 years, with HIV/HCV acquired vertically or in childhood, were included...
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27898592/the-hepatitis-c-virus-nonstructural-protein-3-q80k-polymorphism-is-frequently-detected-and-transmitted-among-hiv-infected-msm-in-the-netherlands
#8
Astrid M Newsum, Cynthia K Y Ho, Faydra I Lieveld, Thijs J W van de Laar, Sylvie M Koekkoek, Sjoerd P Rebers, Jan T M van der Meer, Anne M J Wensing, Greet J Boland, Joop E Arends, Karel J van Erpecum, Maria Prins, Richard Molenkamp, Janke Schinkel
OBJECTIVES: The Q80K polymorphism is a naturally occurring resistance-associated variant in the hepatitis C virus (HCV) nonstructural protein 3 (NS3) region and is likely transmissible between hosts. This study describes the Q80K origin and prevalence among HCV risk groups in the Netherlands and examines whether Q80K is linked to specific transmission networks. DESIGN AND METHODS: Stored blood samples from HCV genotype 1a-infected patients were used for PCR and sequencing to reconstruct the NS3 maximum likelihood phylogeny...
January 2, 2017: AIDS
https://www.readbyqxmd.com/read/27898577/decline-in-herpes-simplex-virus-type-2-among-non-injecting-heroin-and-cocaine-users-in-new-york-city-2005-to-2014-prospects-for-avoiding-a-resurgence-of-human-immunodeficiency-virus
#9
Don C Des Jarlais, Kamyar Arasteh, Jonathan Feelemyer, Courtney McKnight, Susan Tross, David C Perlman, Aimee N C Campbell, Holly Hagan, Hannah L F Cooper
BACKGROUND: Herpes simplex virus type 2 (HSV-2) infection increases both susceptibility to and transmissibility of human immunodeficiency virus (HIV), and HSV-2 and HIV are often strongly associated in HIV epidemics. We assessed trends in HSV-2 prevalence among non-injecting drug users (NIDUs) when HIV prevalence declined from 16% to 8% among NIDUs in New York City. METHODS: Subjects were current non-injecting users of heroin and/or cocaine and who had never injected illicit drugs...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27898525/characterization-of-hcv-ns3-protease-variants-in-hcv-hiv-coinfected-patients-by-ultra-deep-sequence-analysis-relationship-to-hepatic-fibrosis
#10
Enass A Abdel-Hameed, Susan D Rouster, Xiang Zhang, Jing Chen, Mario Medvedovic, Zachary D Goodman, Kenneth E Sherman
BACKGROUND: Treatment of HCV/HIV coinfection is now largely based upon utilization of direct acting agents. Pre-treatment viral resistant-associated variants (RAVs) and host liver condition may affect the sustained virological response. In this study, we explored relative prevalence of protease resistance-associated mutations, the evolution of those RAVs following 12 weeks of pegylated interferon alfa exposure, and the role hepatic fibrosis might have on RAV display. METHODS: Thirty nonresponder HCV/ HIV coinfected subjects were evaluated pre- and post- 12 weeks of pegIFN treatment...
November 25, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27895845/a-trial-of-a-7-valent-pneumococcal-conjugate-vaccine-in-hiv-infected-adults
#11
Neil French, Stephen B Gordon, Thandie Mwalukomo, Sarah A White, Gershom Mwafulirwa, Herbert Longwe, Martin Mwaiponya, Eduard E Zijlstra, Malcolm E Molyneux, Charles F Gilks
BACKGROUND: Streptococcus pneumoniae is a leading and serious coinfection in adults with human immunodeficiency virus (HIV) infection, particularly in Africa. Prevention of this disease by vaccination with the current 23-valent polysaccharide vaccine is suboptimal. Protein conjugate vaccines offer a further option for protection, but data on their clinical efficacy in adults are needed. METHODS: In this double-blind, randomized, placebo-controlled clinical efficacy trial, we studied the efficacy of a 7-valent conjugate pneumococcal vaccine in predominantly HIV-infected Malawian adolescents and adults who had recovered from documented invasive pneumococcal disease...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27895272/dengue-infection-in-a-human-immunodeficiency-virus-1-positive-patient-chronically-infected-with-hepatitis-b-virus-in-western-mexico
#12
Iván Delgado-Enciso, Francisco Espinoza-Gómez, Rodolfo Ochoa-Jiménez, Salvador Valle-Reyes, Clemente Vásquez, Uriel A López-Lemus
Human immunodeficiency virus (HIV) and dengue coinfection has not been extensively studied. We report herein a case of dengue serotype 1 infection in an HIV-1-positive patient coinfected with hepatitis B virus (HBV) in Colima State, Mexico. CD4(+) cells and HIV-1 viremia remained at normal levels, and no severe complications were observed during this multiple viral infection. The alanine transaminase and aspartate transaminase AST values were elevated before and during dengue infection. Surprisingly, these parameters were significantly reduced 2 months later...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27895127/the-pathogenic-potential-of-proteus-mirabilis-is-enhanced-by-other-uropathogens-during-polymicrobial-urinary-tract-infection
#13
Chelsie E Armbruster, Sara N Smith, Alexandra O Johnson, Valerie DeOrnellas, Kathryn A Eaton, Alejandra Yep, Lona Mody, Weisheng Wu, Harry L T Mobley
Urinary catheter use is prevalent in health care settings, and polymicrobial colonization by urease-positive organisms, such as Proteus mirabilis and Providencia stuartii, commonly occurs with long-term catheterization. We previously demonstrated that coinfection with P. mirabilis and P. stuartii increased overall urease activity in vitro and disease severity in a model of urinary tract infection (UTI). In this study, we expanded these findings to a murine model of catheter-associated UTI (CAUTI), delineated the contribution of enhanced urease activity to coinfection pathogenesis, and screened for enhanced urease activity with other common CAUTI pathogens...
November 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27885762/esophageal-tuberculosis-with-coexisting-opportunistic-infections-in-a-renal-allograft-transplant-recipient
#14
Sunil Kumar, Mukut Minz, Saroj K Sinha, Kim Vaiphei, Ashish Sharma, Sarbpreet Singh, Deepesh B Kenwar
We report a renal allograft transplant recipient with esophageal tuberculosis (TB) coinfected with herpes simplex virus (HSV) and Candida. The patient presented with oropharyngeal candidiasis and was started on fluconazole. Upper gastrointestinal endoscopy showed whitish patches with mucosal ulcers in the esophagus. Histopathological examination confirmed TB and HSV infection. The patient recovered after antiviral, antifungal, and anti-tubercular therapy with reduction in immunosuppression. In a TB-endemic zone, TB can coexist with opportunistic infections in an immunocompromised host...
November 25, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27885757/role-of-primary-t-cell-immunodeficiency-and-hepatitis-b-coinfection-on-spontaneous-clearance-of-hepatitis-c-the-bc-hepatitis-testers-cohort
#15
N Islam, M Krajden, M Gilbert, P Gustafson, A Yu, M Kuo, M Chong, M Alvarez, J Wong, M W Tyndall, N Z Janjua
T-cell host immune response against hepatitis C virus (HCV) has been suggested to play an important role in determining HCV infection outcome. However, data from human studies are not available. This study examined the effect of primary T-cell deficiency along with other factors on the spontaneous clearance of HCV in a large population-based cohort in British Columbia, Canada. The BC Hepatitis Testers Cohort includes all individuals tested for HCV in BC in 1990-2013 linked with data on their medical visits, hospitalizations and prescription drugs...
November 25, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27883411/acute-liver-failure-during-treatment-of-interferon-alpha-2a-chronic-hepatitis-b-and-coinfection-of-parvovirus-b19
#16
Barbara Sobala-Szczygieł, Anna Boroń-Kaczmarska, Lucjan Kępa, Barbara Oczko-Grzesik, Damian Piotrowski, Wojciech Stolarz
Parvovirus B19 infection is associated with a broad spectrum of clinical manifestations among which some are well known but others remain controversial. The role of this infection as a cause of acute hepatitis or exacerbation of chronic liver disease requires discussion regarding its significance in a strategy of prevention and treatment of patients with chronic hepatitis. Clinical importance of this infection in patients with chronic hepatitis B treated with pegylated interferon alpha 2a is still unclear but exactly in this population significant complications during treatment may arise...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27883410/acute-liver-failure-during-treatment-of-interferon-alpha-2a-chronic-hepatitis-b-and-coinfection-of-parvovirus-b19
#17
Barbara Sobala-Szczygieł, Anna Boroń-Kaczmarska, Lucjan Kępa, Barbara Oczko-Grzesik, Damian Piotrowski, Wojciech Stolarz
No abstract text is available yet for this article.
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27883373/clinical-impact-of-mixed-respiratory-viral-infection-in-children-with-adenoviral-infection
#18
Hyun Jun Lee, Young Eun Seo, Seung Beom Han, Dae Chul Jeong, Jin Han Kang
BACKGROUND: Although adenovirus (ADV) infection occurs steadily all year round in Korea and the identification of respiratory viral coinfections has been increasing following the introduction of multiplex real-time polymerase chain reaction tests, the clinical impact of viral coinfection in children with ADV infection has rarely been reported. MATERIALS AND METHODS: Medical records of children diagnosed with ADV infection were retrospectively reviewed. The enrolled children were divided into two groups based on the identified respiratory viruses: ADV group and coinfection group...
November 21, 2016: Infection & Chemotherapy
https://www.readbyqxmd.com/read/27882759/-management-of-care-of-hiv-positive-pregnant-women-in-the-period-1996-2014
#19
M Mojhová, I Mikysková, M Halaška, M Staňková, H Rozsypal, J Šrámek, J Záhumenský, M Malý
OBJECTIVE: The evaluation of multidisplinary care about HIV positive pregnant women in the Czech Republic. DESIGN: Review. SETTINGS: Gynekologicko-porodnická klinika 1. LF UK a Nemocnice na Bulovce, Praha. METHODS: The vertical transmission of HIV infection from mother to fetus occurs most often during birth, still 1-2% of HIV-positive pregnant women will transfer the virus transplacenta. Due to careful screening for HIV during pregnancy, counselling, combination antiretroviral (cART) therapy, childbirth planning and its performance by C-section there appears a significant decrease of the virus transmission to the fetus, its occurrence is around 2%...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27882706/high-frequency-of-potential-interactions-between-direct-acting-antivirals-and-concomitant-therapy-in-hiv-hepatitis-c-virus-coinfected-patients-in-clinical-practice
#20
J Macías, P Monge, M Mancebo, N Merchante, K Neukam, L M Real, J A Pineda
OBJECTIVES: The aim of the study was to analyse the frequency and degree of potential drug-drug interactions (DDIs) between direct-acting antivirals (DAAs) and concomitant medication used by HIV/hepatitis C virus (HCV)-coinfected patients, including antiretroviral therapy (ART) and other drugs. METHODS: All patients with HIV infection and viraemic HCV genotype 1, 3 or 4 coinfection attending a tertiary care centre in Spain (November 2014 to November 2015) were included in the study...
November 24, 2016: HIV Medicine
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