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https://www.readbyqxmd.com/read/29150931/microrna-497-accelerates-apoptosis-while-inhibiting-proliferation-migration-and-invasion-through-negative-regulation-of-the-mapk-erk-signaling-pathway-via-raf-1
#1
Ling Tao, Xia Li, Na-Na Han, Qi Zhou, Zhi-Le Liu
The aim of this study is to explore the various modes of action miR-497 has on human cervical cancer (CC) cell behavior. We also speculate that miR-497 achieves its anti-tumor role by governing RAF-1 via MAPK/ERK signaling pathway. CC tissues with corresponding adjacent normal tissues were collected from 168 CC patients. RAF-1-positive cells were identified by means of immunohistochemistry in tissues. A series of inhibitors, mimics and siRNA against RAF-1 were introduced to validate regulatory mechanisms for miR-497 and RAF-1...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150734/the-sirtuin-1-2-inhibitor-tenovin-1-induces-a-nonlinear-apoptosis-inducing-factor-dependent-cell-death-in-a-p53-null-ewing-s-sarcoma-cell-line
#2
Christian Marx, Lisa Marx-Blümel, Nora Lindig, René Thierbach, Doerte Hoelzer, Sabine Becker, Susan Wittig, Roland Lehmann, Hortense Slevogt, Thorsten Heinzel, Zhao-Qi Wang, James F Beck, Jürgen Sonnemann
The sirtuin 1/2 inhibitor tenovin-1 activates p53 and may have potential in the management of cancer. Here, we investigated the responsiveness of Ewing's sarcoma cells to tenovin-1. We examined its effects in two Ewing's sarcoma cell lines with different p53 status, i.e. in p53 wild-type and p53 null cells. Effects were assessed by flow cytometric analyses of cell death, mitochondrial membrane depolarization and reactive oxygen species (ROS) generation, by caspase 3/7 activity measurement, by mRNA expression profiling and by immunoblotting...
November 18, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29150697/a-novel-allele-of-tagw2-a1-is-located-in-a-finely-mapped-qtl-that-increases-grain-weight-but-decreases-grain-number-in-wheat-triticum-aestivum-l
#3
Huijie Zhai, Zhiyu Feng, Xiaofen Du, Yane Song, Xinye Liu, Zhongqi Qi, Long Song, Jiang Li, Linghong Li, Huiru Peng, Zhaorong Hu, Yingyin Yao, Mingming Xin, Shihe Xiao, Qixin Sun, Zhongfu Ni
A novel TaGW2-A1 allele was identified from a stable, robust QTL region, which is pleiotropic for thousand grain weight, grain number per spike, and grain morphometric parameters in wheat. Thousand grain weight (TGW) and grain number per spike (GNS) are two crucial determinants of wheat spike yield, and genetic dissection of their relationships can help to fine-tune these two components and maximize grain yield. By evaluating 191 recombinant inbred lines in 11 field trials, we identified five genomic regions on chromosomes 1B, 3A, 3B, 5B, or 7A that solely influenced either TGW or GNS, and a further region on chromosome 6A that concurrently affected TGW and GNS...
November 17, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29150691/mechanical-regulation-of-organ-asymmetry-in-leaves
#4
Jiyan Qi, Binbin Wu, Shiliang Feng, Shouqin Lü, Chunmei Guan, Xiao Zhang, Dengli Qiu, Yingchun Hu, Yihua Zhou, Chuanyou Li, Mian Long, Yuling Jiao
How appendages, such as plant leaves or animal limbs, develop asymmetric shapes remains a fundamental question in biology. Although ongoing research has revealed the genetic regulation of organ pattern formation, how gene activity ultimately directs organ shape remains unclear. Here, we show that leaf dorsoventral (adaxial-abaxial) polarity signals lead to mechanical heterogeneity of the cell wall, related to the methyl-esterification of cell-wall pectins in tomato and Arabidopsis. Numerical simulations predicate that mechanical heterogeneity is sufficient to produce the asymmetry seen in planar leaves...
September 2017: Nature Plants
https://www.readbyqxmd.com/read/29150655/reverse-engineering-protocols-for-controlling-spin-dynamics
#5
Qi Zhang, Xi Chen, D Guéry-Odelin
We put forward reverse engineering protocols to shape in time the components of the magnetic field to manipulate a single spin, two independent spins with different gyromagnetic factors, and two interacting spins in short amount of times. We also use these techniques to setup protocols robust against the exact knowledge of the gyromagnetic factors for the one spin problem, or to generate entangled states for two or more spins coupled by dipole-dipole interactions.
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150565/the-role-of-macrophages-in-the-response-to-tnf-inhibition-in-experimental-arthritis
#6
Qi-Quan Huang, Robert Birkett, Renee Doyle, Bo Shi, Elyssa L Roberts, Qinwen Mao, Richard M Pope
The reduction of synovial tissue macrophages is a reliable biomarker for clinical improvement in patients with rheumatoid arthritis (RA), and macrophages are reduced in synovial tissue shortly after initiation of TNF inhibitors. The mechanism for this initial response is unclear. These studies were performed to identify the mechanisms responsible for the initial reduction of macrophages following TNF inhibition, positing that efflux to draining lymph nodes was involved. RA synovial tissue and synovial fluid macrophages expressed CCR7, which was increased in control macrophages following incubation with TNF-α...
November 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29150438/a-pip2-derived-amplification-loop-fuels-the-sustained-initiation-of-b-cell-activation
#7
Chenguang Xu, Hengyi Xie, Xingdong Guo, Haipeng Gong, Lei Liu, Hai Qi, Chenqi Xu, Wanli Liu
Lymphocytes have evolved sophisticated signaling amplification mechanisms to efficiently activate downstream signaling after detection of rare ligands in their microenvironment. B cell receptor microscopic clusters (BCR microclusters) are assembled on the plasma membrane and recruit signaling molecules for the initiation of lymphocyte signaling after antigen binding. We identified a signaling amplification loop derived from phosphatidylinositol 4,5-biphosphate (PIP2) for the sustained B cell activation. Upon antigen recognition, PIP2 was depleted by phospholipase C-γ2 (PLC-γ2) within the BCR microclusters and was regenerated by phosphatidic acid-dependent type I phosphatidylinositol 4-phosphate 5-kinase outside the BCR microclusters...
November 17, 2017: Science Immunology
https://www.readbyqxmd.com/read/29150431/the-e3-ubiquitin-ligase-apc-c-c-dh1-degrades-mcph1-after-mcph1-%C3%AE-trcp2-cdc25a-mediated-mitotic-entry-to-ensure-neurogenesis
#8
Xiaoqian Liu, Wen Zong, Tangliang Li, Yujun Wang, Xingzhi Xu, Zhong-Wei Zhou, Zhao-Qi Wang
Mutations of microcephalin (MCPH1) can cause the neurodevelopmental disorder primary microcephaly type 1. We previously showed that MCPH1 deletion in neural stem cells results in early mitotic entry that distracts cell division mode, leading to exhaustion of the progenitor pool. Here, we show that MCPH1 interacts with and promotes the E3 ligase βTrCP2 to degrade Cdc25A independent of DNA damage. Overexpression of βTrCP2 or the knockdown of Cdc25A remedies the high mitotic index and rescues the premature differentiation of Mcph1-deficient neuroprogenitors in vivo MCPH1 itself is degraded by APC/C(C)(dh1), but not APC/C(C)(dc20), in late mitosis and G1 phase...
November 17, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29149799/two-new-sucrose-esters-from-the-rhizome-of-sparganium-stoloniferum-buch-ham
#9
Qi Zong, Ying Xiong, Kezhong Deng
Two new sucrose esters, β-D-(1-O-acetyl-3,6-O-trans-diferuloyl)fructofuranosyl-α-D-2'-O-acetylglucopyranoside (1) and β-D-(1-O-acetyl-3-O-cis-feruloyl-6-O-trans-feruloyl)fructofuranosyl-α-D-2',4',6'-O-triacetylglucopyranoside (2), together with four known sucrose esters (3-6) have been isolated from the rhizome of Sparganium stoloniferum Buch.-Ham. Their structures were elucidated by physical and chemical evidence and spectral analysis.
November 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29149775/lentiviral-vectors-and-adeno-associated-virus-vectors-useful-tools-for-gene-transfer-in-pain-research
#10
REVIEW
Zheng Chen-Xi, Wang Sheng-Ming, Bai Yun-Hu, Luo Ting-Ting, Wang Jia-Qi, Dai Chun-Qiu, Guo Bao-Lin, Luo Shi-Cheng, Wang Dong-Hui, Yang Yan-Ling, Wang Ya-Yun
Pain, especially chronic pain, has always been a heated point in both basic and clinical researches since it puts heavy burdens on both individuals and the whole society. A better understanding of the role of biological molecules and various ionic channels involved in pain can shed light on the mechanism under pain and advocate the development of pain management. Using viral vectors to transfer specific genes at targeted sites is a promising method for both research and clinical applications. Lentiviral vectors and adeno-associated virus (AAV) vectors which allow stable and long-term expression of transgene in non-dividing cells are widely applied in pain research...
November 17, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29149634/patient-participation-in-nursing-bedside-handover-a-systematic-mixed-methods-review
#11
REVIEW
Georgia Tobiano, Tracey Bucknall, Ishtar Sladdin, Jennifer A Whitty, Wendy Chaboyer
BACKGROUND: Numerous reviews of nursing handover have been undertaken, but none have focused on the patients' role. OBJECTIVES: To explore how patient participation in nursing shift-to-shift bedside handover can be enacted. DESIGN: Systematic mixed- methods review. DATA SOURCES: Three search strategies were undertaken in July-August 2016: database searching, backwards citation searching and forward citation searching...
October 24, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29149492/effects-of-tao-hong-si-wu-decoction-on-acute-blood-stasis-in-rats-based-on-a-lc-q-tof-ms-metabolomics-and-network-approach
#12
Qi Ma, Peng-Ling Li, Yong-Li Hua, Peng Ji, Wan-Ling Yao, Xiao-Song Zhang, Li-Jia Zhong, Yan-Ming Wei
A novel approach using metabolomics coupled with a metabolic network was used to investigate the effects of THSWD on the rat model of acute blood stasis syndrome. Acute blood stasis syndrome was induced by placing the rats in ice-cold water following two injections with epinephrine. The hemorheological indicators (WBV and PV), and the blood coagulation indicators (TT, PT, APTT, and FIB) were detected. The nonparametric univariate method and multivariate statistical analysis were performed for determining the potential biomarkers...
November 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29149349/social-exclusion-weakens-storage-capacity-and-attentional-filtering-ability-in-visual-working-memory
#13
Mengsi Xu, Senqing Qi, Zhiai Li, Liuting Diao, Lingxia Fan, Lijie Zhang, Dong Yang
Social exclusion has been found to impair visual working memory (WM), while the underlying neural processes are currently unclear. Using two experiments, we tested whether the poor WM performance caused by exclusion was due to reduced storage capacity, impaired attentional filtering ability, or both. The Cyberball game was used to manipulate social exclusion. Seventy-four female participants performed WM tasks while event-related potentials were recorded. In Experiment 1, participants were made to remember the orientations of red rectangles while ignoring salient green rectangles...
November 15, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29149156/survival-analysis-of-occipital-nerve-stimulator-leads-placed-under-fluoroscopic-guidance-with-and-without-ultrasonography
#14
James H Jones, Alison Brown, Daniel Moyse, Wenjing Qi, Lance Roy
BACKGROUND: Electrical stimulation of the greater occipital nerves is performed to treat pain secondary to chronic daily headaches and occipital neuralgia. The use of fluoroscopy alone to guide the surgical placement of electrodes near the greater occipital nerves disregards the impact of tissue planes on lead stability and stimulation efficacy. OBJECTIVE: We hypothesized that occipital neurostimulator (ONS) leads placed with ultrasonography combined with fluoroscopy would demonstrate increased survival rates and times when compared to ONS leads placed with fluoroscopy alone...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29148707/versatile-supermolecular-inclusion-complex-based-on-host-guest-interaction-for-targeted-gene-delivery
#15
Yunxia Sun, Jingyi Zhu, Wen-Xiu Qiu, Qi Lei, Si Chen, Xian-Zheng Zhang
A facile and targeted gene delivery system was prepared by conjugating β-cyclodextrin modified polyethylenimine (PEI-CD) and adamantyl peptide (AdGRGDS) based on host-guest interaction. With the rational design between PEI-CD and AdGRGDS, PEI-CD/AdGRGDS gene delivery system showed excellent DNA binding capability, and exhibited good ability to compact DNA into uniform spherical nanoparticles. In vitro luciferase assay showed that gene expression transfected by PEI-CD/AdGRGDS was stronger than that by PEI-CD in HeLa cells, whereas, gene expression transfected by PEI-CD/AdGRGDS and PEI-CD was similar to each other in COS7 cells...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148704/electrospun-poly-3-hydroxybutyrate-co-4-hydroxybutyrate-graphene-oxide-scaffold-enhanced-properties-and-promoted-in-vivo-bone-repair-in-rats
#16
Tengfei Zhou, Guo Li, Shiyu Lin, Taoran Tian, Quanquan Ma, Qi Zhang, Sirong Shi, Changyue Xue, Wenjuan Ma, Xiaoxiao Cai, Yunfeng Lin
Bone tissue engineering emerges as an advantageous technique to achieve tissue regeneration. Scaffolds for it must present excellent biomechanical properties where bare polymers poorly perform. Development for new biomaterials with high osteogenic capacity is urgently pursued. In this study, an electrospun poly(3-hydroxybutyrate-co-4-hydroxybutyrate/graphene oxide (P34HB/GO) nanofibrous scaffold is successfully fabricated and characterized. The effects of GO amount on scaffold morphology, biomechanical properties, and cellular behaviors are investigated...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148702/influence-of-particle-geometry-on-gastrointestinal-transit-and-absorption-following-oral-administration
#17
Dong Li, Jie Zhuang, Haisheng He, Sifan Jiang, Amrita Banerjee, Yi Lu, Wei Wu, Samir Mitragotri, Li Gan, Jianping Qi
Geometry has been considered as one of the important parameters in nanoparticle design since it affects cellular uptake, transport across the physiological barriers and in vivo distribution. However, only a few studies have been conducted to elucidate the influence of nanoparticle geometry in their in vivo fate after oral administration. This paper discloses the effect of nanoparticle shape on transport and absorption in gastrointestinal tract (GIT). Nanorods and nanospheres were prepared, and labeled using fluorescence resonance energy transfer (FRET) molecules to track the in vivo fate of intact nanoparticles accurately...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148695/a-high-thermal-and-air-stability-cathode-material-with-concentration-gradient-buffer-for-li-ion-batteries
#18
Ji-Lei Shi, Ran Qi, Xu-Dong Zhang, Peng-Fei Wang, Weigui Fu, Ya-Xia Yin, Jian Xu, Li-Jun Wan, Yu-Guo Guo
Delivery of high-capacity with high thermal and air stability is a great challenge in developing of Ni-rich layered cathodes for commercialized Li-ion batteries (LIBs). Herein we present a surface concentration-gradient spherical particle with varying elemental composition from the outer end LiNi1/3Co1/3Mn1/3O2 (NCM) to the inner end LiNi0.8Co0.15Al0.05O2 (NCA). This cathode material with the merit of NCM concentration-gradient protective buffer and the inner NCA core shows high capacity retention of 99.8% after 200 cycles at 0...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148582/comparative-pharmacokinetics-study-of-orientin-in-rat-plasma-by-uhplc-ms-ms-after-intravenous-administration-of-single-orientin-and-trollius-chinensis-bunge-extract
#19
Nan Zhao, Qi Sun, Yang Song, Lin Wang, Tingjian Zhang, Fanhao Meng
Orientin showed a broad array of biological activities, and it is the major bioactive compound in the Trollius chinensis Bunge. Thus, this paper was conducted to investigate the comparative pharmacokinetics of orientin after intravenous administration of single orientin and Trollius chinensis Bunge extract. Sample preparation involved a simple one-step deproteinization procedure with acetonitrile. Chromatographic separation was achieved on a Waters BEH C18 column with a mobile phase consisting of acetonitrile and water containing 0...
November 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29148556/co2-adsorption-on-anatase-tio2-101-surfaces-a-combination-of-uhv-ftirs-and-first-principles-studies
#20
Yunjun Cao, Min Yu, Shandong Qi, Tingting Wang, Shiming Huang, Zhengfeng Ren, Shishen Yan, Shujun Hu, Mingchun Xu
The CO2 adsorption and dynamic behaviors on single crystal anatase TiO2(101) surfaces were investigated by UHV-FTIRS and first-principles calculations. The IRRAS results at 90 K show that the ν3(OCO) asymmetric stretching vibration of adsorbed CO2 exhibits band splitting at rather low CO2 coverage in p-polarized IR spectra for the IR beam incident along the [101[combining macron]] direction. Co-adsorbed CO can prevent such band splitting. Ab initio molecular dynamics (AIMD) simulations revealed that the adsorbed CO2 at finite temperature does not keep a stationary adsorption state but keeps a certain swing motion: one end of the linear CO2 molecule binds to surface Ti5c sites and the other end swings within the (010) plane with a tilted angle distribution ranging from 10° to 60° relative to the [101[combining macron]] direction...
November 17, 2017: Physical Chemistry Chemical Physics: PCCP
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