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https://www.readbyqxmd.com/read/28535658/-value-of-the-endoscopic-diagnosis-on-the-lesions-of-the-skull-base-in-postradiotherapeutic-patients-with-nasopharyngeal-carcinoma
#1
J Y Lyu, F Y Liang, P Han, X M Huang
Objective: To evaluate the diagnostic value of the endoscopic biopsy operation to the lesions of the skull base in the patients with nasopharyngealcarcinoma after radiotherapy. Methods: From February 2006 to February 2010, 84 patients with nasopharyngeal carcinoma suffered from the lesions of the skull base after radiotherapy were included in this study. The relationship between the pathologic results of endoscopic biopsies from the skull base and the imaging results by Magnetic Resonance Imaging(MRI) was compared and discussed...
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28535611/sea-buckthorn-hippophae-rhamnoides-l-leaf-extracts-protect-neuronal-pc-12-cells-from-oxidative-stress
#2
Chi Heung Cho, Ho Lim Jang, Migi Lee, Hee Kang, Ho Jjn Heo, Dae-Ok Kim
The present study was carried out to investigate the antioxidative and neuroprotective effects of sea buckthorn (Hippophae rhamnoides L.) leaves (SBL) harvested at different times. Reversed-phase high-performance liquid chromatography analysis revealed five major phenolic compounds: ellagic acid, gallic acid, isorhamnetin, kaempferol, and quercetin. SBL harvested in August had the highest total phenolic and flavonoid contents and antioxidant capacity. Treatment of neuronal PC-12 cells with the ethyl acetate fraction of SBL harvested in August in increased their viability and membrane integrity and reduced intracellular oxidative stress in a dose-dependent manner...
May 24, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28535506/long-noncoding-rna-afap1-as1-promoted-tumor-growth-and-invasion-in-cholangiocarcinoma
#3
Xu Lu, Chuang Zhou, Renfeng Li, Yilei Deng, Longshuan Zhao, Wenlong Zhai
BACKGROUND: Long non-coding RNAs (lncRNAs) have been shown to play important roles in a wide range of pathophysiological processes, including cancer progression. Our previous study has shown that AFAP1-AS1 was upregulated and acted as an oncogene in hepatocellular carcinoma. However, the expression and biological functions of lncRNA AFAP1-AS1 in intrahepatic cholangiocarcinoma (CCA) remains largely unknown. METHODS: The expression level of AFAP1-AS1 was measured in 56 pairs of human cholangiocarcinoma tumor tissues and corresponding adjacent normal bile duct tissues...
May 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28535473/length-effect-of-methoxy-poly-ethylene-oxide-b-poly-%C3%AE%C2%B5-caprolactone-g-poly-methacrylic-acid-copolymers-on-cisplatin-delivery
#4
Hsuan-Ying Chen, Yu-Lun Lo, Pei-Ling Wu, Pei-Chi Lo, Li-Fang Wang
Novel comb-shaped amphiphilic copolymers based on methoxy poly(ethylene glycol)-b-[poly(ε-caprolactone)-g-poly(methacrylic acid)] (MPCL-g-pMAA), were synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) for drug delivery systems. MPCL-g-pMAAs with various MAA repeating units self-assemble into a core-shell structure in an aqueous solution. Critical aggregation concentrations range within 5.6×10(-3)-7.0×10(-2)mg/mL in double deionized water and 8.9×10(-3)-7.0×10(-2)mg/mL in phosphate buffered saline of pH 7...
May 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28535458/mtor-signaling-in-the-differentiation-and-function-of-regulatory-and-effector-t-cells
#5
REVIEW
Hu Zeng, Hongbo Chi
The mechanistic target of rapamycin (mTOR) signaling pathway integrates environmental signals and cellular metabolism to regulate T cell development, activation and differentiation. Recent studies reveal the importance of exquisite control of mTOR activity for proper T cell function, and detailed molecular mechanisms that regulate mTOR signaling in different T cell subsets. Here, we review the latest advances in our understanding of the mTOR pathway and its regulation in the differentiation and function of regulatory T cells and effector T cells...
May 20, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28535404/placental-inflammation-and-its-relationship-to-cervicovaginal-fetal-fibronectin-in-preterm-birth
#6
Laura van der Krogt, Alexandra E Ridout, Paul T Seed, Andrew H Shennan
OBJECTIVE: Late miscarriage and preterm birth are frequently thought to be associated with inflammation and infection, although in most cases the underlying cause of early delivery remains unknown. The placenta is the organ that links mother and fetus during pregnancy, and postnatal examination may provide useful information about pathophysiology. The relationship between placental pathological lesions and predictive markers of early delivery has not been explored. We sought to characterize preterm deliveries according to placental pathology and relate these to the performance of reliable predictive markers, fetal fibronectin and cervical length...
May 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28535331/computer-and-mobile-technology-interventions-for-self-management-in-chronic-obstructive-pulmonary-disease
#7
REVIEW
Catherine McCabe, Margaret McCann, Anne Marie Brady
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterised by airflow obstruction due to an abnormal inflammatory response of the lungs to noxious particles or gases, for example, cigarette smoke. The pattern of care for people with moderate to very severe COPD often involves regular lengthy hospital admissions, which result in high healthcare costs and an undesirable effect on quality of life. Research over the past decade has focused on innovative methods for developing enabling and assistive technologies that facilitate patient self-management...
May 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28534934/overexpression-of-stromal-interaction-molecule-1-may-promote-epithelial%C3%A2-mesenchymal-transition-and-indicate-poor-prognosis-in-gastric-cancer
#8
Guobin Wu, Yong Li, Bibo Tan, Liqiao Fan, Qun Zhao, Yü Liu, Zhidong Zhang
The aim of the present study was to investigate the prognostic significance of stromal interaction molecule 1 (STIM1) expression in gastric cancer (GC) and examine the association between STIM1 and epithelial‑mesenchymal transition (EMT). Immunohistochemical staining was performed to detect STIM1, E‑cadherin, β‑catenin and matrix metalloproteinase‑9 (MMP‑9) in 170 GC and 35 adjacent healthy gastric tissue samples. Positive staining of STIM1, E‑cadherin, β‑catenin and MMP‑9 in GC tissues was significantly greater compared with adjacent healthy tissues (P<0...
May 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534849/evaluation-and-comparison-of-the-pathogenicity-and-host-immune-responses-induced-by-a-g2b-taiwan-porcine-epidemic-diarrhea-virus-strain-pintung-52-and-its-highly-cell-culture-passaged-strain-in-conventional-5-week-old-pigs
#9
Yen-Chen Chang, Chi-Fei Kao, Chia-Yu Chang, Chian-Ren Jeng, Pei-Shiue Tsai, Victor Fei Pang, Hue-Ying Chiou, Ju-Yi Peng, Ivan-Chen Cheng, Hui-Wen Chang
A genogroup 2b (G2b) porcine epidemic diarrhea virus (PEDV) Taiwan Pintung 52 (PEDVPT) strain was isolated in 2014. The pathogenicity and host antibody responses elicited by low-passage (passage 5; PEDVPT-P5) and high-passage (passage 96; PEDVPT-P96) PEDVPT strains were compared in post-weaning PEDV-seronegative pigs by oral inoculation. PEDVPT-P5-inoculation induced typical diarrhea during 1-9 days post inoculation with fecal viral shedding persisting for 26 days. Compared to PEDVPT-P5, PEDVPT-P96 inoculation induced none-to-mild diarrhea and lower, delayed fecal viral shedding...
May 19, 2017: Viruses
https://www.readbyqxmd.com/read/28534776/globally-consistent-wrinkle-aware-shading-of-line-drawings
#10
Pradeep Kumar Jayaraman, Chi-Wing Fu, Jianmin Zheng, Xueting Liu, Tien-Tsin Wong
Shading is a tedious process for artists involved in 2D cartoon and manga production given the volume of contents that the artists have to prepare regularly over tight schedule. While we can automate shading production with the presence of geometry, it is impractical for artists to model the geometry for every single drawing. In this work, we aim to automate shading generation by analyzing the local shapes, connections, and spatial arrangement of wrinkle strokes in a clean line drawing. By this, artists can focus more on the design rather than the tedious manual editing work, and experiment with different shading effects under different conditions...
May 17, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28534770/boscc-bag-of-spatial-context-correlations-for-spatially-enhanced-3d-shape-representation
#11
Zhizhong Han, Zhenbao Liu, Chi-Man Vong, Yu-Shen Liu, Shuhui Bu, Junwei Han, Philip Chen
Highly discriminative 3D shape representations can be formed by encoding the spatial relationship among virtual words into the Bag of Words (BoW) method. To achieve this challenging task, several unresolved issues in the encoding procedure must be overcome for 3D shapes, including i) arbitrary mesh resolution, ii) irregular vertex topology, iii) orientation ambiguity on the 3D surface and iv) invariance to rigid and non-rigid shape transformations. In this work, a novel spatially enhanced 3D shape representation called Bag of Spatial Context Correlations (BoSCC) is proposed to address all these issues...
May 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28534372/serum-expression-level-of-mir-504-can-differentiate-between-glioblastoma-multiforme-and-solitary-brain-metastasis-of-non-small-cell-lung-carcinoma
#12
Zheng Jin, Ri-Hua Jin, Chi Ma, Hai-Song Li, Hai-Yang Xu
PURPOSE: Gliomas are the most common primary intracranial tumors of the central nervous system (CNS), accounting for about one third of all brain tumors. Glioblastoma multiforme (GBM) is the aggressive grade IV glioma with survival as low as 2-5% in the second year post-diagnosis, hence necessitating efficient diagnostic markers. More than 50% of the non-small cell lung cancer (NSCLC) brain metastases are solitary lesions, often difficult to differentiate from gliomas by conventional imaging diagnostics...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28534281/elder-mistreatment-perpetrators-with-substance-abuse-and-or-mental-health-conditions-results-from-the-national-elder-mistreatment-study
#13
Travis Labrum, Phyllis L Solomon
A large portion of persons who commit elder mistreatment have long been known to have indicators of substance abuse and/or mental health conditions (SAMHC). However, few studies have specifically examined elder mistreatment by persons with SAMHC, preventing the development of specialized intervention strategies. Using results from the National Elder Mistreatment Study, the current article examines victim, perpetrator, and interaction characteristics between cases of emotional and physical elder mistreatment in which the perpetrator is reported to have vs...
May 23, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28534211/associations-between-yoga-practice-and-joint-problems-a-cross-sectional-survey-among-9151-australian-women
#14
Romy Lauche, Dania Schumann, David Sibbritt, Jon Adams, Holger Cramer
Yoga exercises have been associated with joint problems recently, indicating that yoga practice might be potentially dangerous for joint health. This study aimed to analyse whether regular yoga practice is associated with the frequency of joint problems in upper middle-aged Australian women. Women aged 62-67 years from the Australian Longitudinal Study on Women's Health (ALSWH) were questioned in 2013 whether they experienced regular joint pain or problems in the past 12 months and whether they regularly practiced yoga...
May 22, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28534172/the-influence-of-local-therapy-on-the-survival-of-patients-with-metastatic-rectal-cancer-a-population-based-propensity-matched-study
#15
Chi-Hao Zhang, Yuan-Bo Pan, Qing-Wei Zhang, Ou-Min Shi, Lei Zheng, Liang Gui, Meng Luo
PURPOSE: This study was aimed to determine the effect of the local tumor therapy on patients' prognosis in the management of metastatic rectal cancer. METHODS: Patients diagnosed with metastatic rectal cancer from 2004 to 2013 were selected from the SEER (Surveillance, Epidemiology, and End Results) database. Overall survival and cancer-specific survival were compared between the local treatment group and the nonlocal treatment group using Kaplan-Meier methods. Uni- and multivariate analyses were further performed to confirm or deny the results...
May 22, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28534023/sexting-prevalence-predictors-and-associated-sexual-risk-behaviors-among-postsecondary-school-young-people-in-ibadan-nigeria
#16
Oluwatoyin Olatunde, Folusho Balogun
BACKGROUND AND AIMS: Sending and receiving sexually suggestive or explicit images or texts (sexting) have been shown to be associated with health risk behaviors but literature about this phenomenon is scarce in Nigeria. This study looked at the prevalence, predictors, and associated sexual risk behaviors of sexting among postsecondary school young persons in Ibadan, Nigeria. METHODS: This was a cross-sectional study using a self-administered questionnaire. Data were obtained for sociodemographic characteristics and sexual orientation, sexting behavior, personality assessment (using the International Personality Item Pool Big-Five factor markers), indicators for problematic phone use (using Mobile Phone Problem Use Scale), and sexual behavior...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28534008/a-comparison-of-pediatric-vs-adult-patients-with-the-ewing-sarcoma-family-of-tumors
#17
Vivek Verma, Kyle A Denniston, Christopher J Lin, Chi Lin
PURPOSE: This study sought to identify differences in clinical characteristics, outcomes, and treatments between adult and pediatric patients with the Ewing sarcoma family of tumors (ESFT). METHODS: By using the Surveillance, Epidemiology, and End Results database from 1983 to 2013, 1,870 patients were analyzed (n = 976 pediatric, n = 894 adult). Between the two groups, demographic, tumor, and treatment characteristics were collated and compared. The chi-square test determined differences in proportions of the variables between groups...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28533991/multivariable-analysis-of-factors-affecting-length-of-stay-and-hospital-charges-after-atlantoaxial-fusion
#18
Jian Guan, Michael Karsy, Meic Schmidt, Andrew T Dailey, Erica Bisson
BACKGROUND: Atlantoaxial fusion is an effective procedure for treating degenerative, traumatic, and congenital abnormalities that result in upper cervical instability; however, data on which factors affect the length of stay and hospitalization-related charges are limited. The purpose of this study was to evaluate the pre-, intra-, and postoperative variables that affect these healthcare cost factors for patients undergoing posterior atlantoaxial fusion. METHODS: We retrospectively identified from a clinical database 59 patients who underwent isolated posterior atlantoaxial fusion at a single institution from 2010 to 2015...
April 18, 2017: Curēus
https://www.readbyqxmd.com/read/28533980/mitochondrial-complex-i-deficiency-leads-to-the-retardation-of-early-embryonic-development-in-ndufs4-knockout-mice
#19
Mei Wang, Ya-Ping Huang, Han Wu, Ke Song, Cong Wan, A-Ni Chi, Ya-Mei Xiao, Xiao-Yang Zhao
BACKGROUND: The NDUFS4 gene encodes an 18-kD subunit of mitochondria complex I, and mutations in this gene lead to the development of a severe neurodegenerative disease called Leigh syndrome (LS) in humans. To investigate the disease phenotypes and molecular mechanisms of Leigh syndrome, the Ndufs4 knockout (KO) mouse has been widely used as a novel animal model. Because the homozygotes cannot survive beyond child-bearing age, whether Ndufs4 and mitochondrial complex I influence early embryonic development remains unknown...
2017: PeerJ
https://www.readbyqxmd.com/read/28533857/antibiogram-profile-of-uropathogens-isolated-at-bahir-dar-regional-health-research-laboratory-centre-northwest-ethiopia
#20
Awoke Derbie, Derese Hailu, Daniel Mekonnen, Bayeh Abera, Gashaw Yitayew
INTRODUCTION: Antimicrobial resistance among bacteria that cause urinary tract infection (UTI) has been increasing since the introduction of chemotherapy. This study was aimed to assess the types of isolates from patients with UTI and to determine their current antimicrobial susceptibility profile. METHODS: A record based retrospective analysis of bacterial uropathogens processed in the period of January 2012 to December 2014 at Bahir Dar Health Research Laboratory Center (BRHRLC) was determined...
2017: Pan African Medical Journal
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