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https://www.readbyqxmd.com/read/29161591/cell-invasion-in%C3%A2-vivo-via-rapid-exocytosis-of-a-transient-lysosome-derived-membrane-domain
#1
Kaleb M Naegeli, Eric Hastie, Aastha Garde, Zheng Wang, Daniel P Keeley, Kacy L Gordon, Ariel M Pani, Laura C Kelley, Meghan A Morrissey, Qiuyi Chi, Bob Goldstein, David R Sherwood
Invasive cells use small invadopodia to breach basement membrane (BM), a dense matrix that encases tissues. Following the breach, a large protrusion forms to clear a path for tissue entry by poorly understood mechanisms. Using RNAi screening for defects in Caenorhabditis elegans anchor cell (AC) invasion, we found that UNC-6(netrin)/UNC-40(DCC) signaling at the BM breach site directs exocytosis of lysosomes using the exocyst and SNARE SNAP-29 to form a large protrusion that invades vulval tissue. Live-cell imaging revealed that the protrusion is enriched in the matrix metalloprotease ZMP-1 and transiently expands AC volume by more than 20%, displacing surrounding BM and vulval epithelium...
November 20, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29161381/dynamic-change-in-left-ventricular-apical-back-rotation-a-marker-of-diastolic-suction-with-exercise
#2
Sung-Jin Hong, Chi Young Shim, Darae Kim, In-Jeong Cho, Geu-Ru Hong, Sun-Ha Moon, Hyun-Jin Lee, Jin-Kyung Lee, Donghoon Choi, Yangsoo Jang, Jong-Won Ha
Aims: We hypothesized that the absence of a decrease in minimal left ventricular (LV) pressure during exercise would be associated with impaired LV apical back rotation during exercise. Methods and results: A total of 21 patients (59 ± 10 years) underwent invasive LV pressure measurements and simultaneous echocardiography at rest and during submaximal supine bicycle exercise. Patients were classified according to the changes in minimal LV pressure from rest to maximal exercise (Δminimal LVP); Group 1 (n = 8) had a decrease in minimal LV pressure with exercise, whereas Group 2 (n = 13) had an increase in minimal LV pressure...
November 17, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29160940/morphological-transformation-of-hbmsc-from-2d-monolayer-to-3d-microtissue-on-low-crystallinity-sf-pcl-patch-with-promotion-of-cardiomyogenesis
#3
Hsin-Yu Lo, An-Li Huang, Pei-Chi Lee, Tze-Wen Chung, Shoei-Shen Wang
The effects of the stiffness of substrates on the cell behaviors of hBMSC have been investigated but the effects of the secondary structures of proteins in the substrates on the morphological transformation and differentiation of hBMSC have yet been elucidated. To investigate these issues, SP cardiac patches of poly(ε-caprolactone) (P), on which is grafted by silk (SF) with various β-sheet contents (or crystallinity) to provide various degrees of stiffness, were produced to examine the in-vitro behaviors of hBMSC during proliferation, and cardiomyogenesis on the SP patches...
November 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29160719/geographical-proximity-and-depressive-symptoms-among-adult-child-caregivers-social-support-as-a-moderator
#4
Mengting Li, Weiyu Mao, Iris Chi, Vivian W Q Lou
OBJECTIVES: This study examined whether geographical proximity is a predictor of depressive symptoms, and whether family and friend support can moderate the relationship between geographical proximity and depressive symptoms. METHOD: A survey of 557 adult child primary caregivers was conducted in Shanghai, China in 2013. Geographical proximity was measured as a categorical variable: coresidence, short distance (less than 30 minutes' travel time), and long distance (more than 30 minutes' travel time)...
November 21, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29160718/social-and-leisure-activity-profiles-and-well-being-among-the-older-adults-a-longitudinal-study
#5
Joulain Michèle, Martinent Guillaume, Taliercio Alain, Bailly Nathalie, Ferrand Claude, Gana Kamel
OBJECTIVES: Studies highlight the beneficial effects of social and leisure activities on the well-being of aging people. Our aims were: to investigate activity profiles among older adults living in their own homes, to highlight potential changes in profiles over a period of five years and to examine effects of differences between these profiles on well-being variables. METHODS: Three waves were considered in this longitudinal study, with 550, 410 and 374 people (76, 79, 82 years on average), respectively...
November 21, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29160601/metalated-chromene-and-chromone-complexes-ph-switchable-metal-carbon-bonding-interaction-photo-triggerable-chromone-delivery-application-and-antioxidative-activity
#6
Sze-Wing Ng, Lai-Hon Chung, Chi-Fung Yeung, Hoi-Shing Lo, Hau-Lam Shek, Tian-Shu Kang, Chung-Hang Leung, Chun-Yuen Wong
The two families of Ru(II)-chromene and -chromone complexes isolated in this work represent the first examples of metalated chromene and chromone complexes synthesized through transition-metal mediated cyclization of phenol-tethered ynone. These unprecedented metalated heterocyclic compounds exhibit remarkable features, such as pH-switchable metal-carbon bonding interactions, photo-triggerable release of organic chromone upon visible-light irradiation, and superior antioxidative property to their organic analog (1,4-benzopyrone)...
November 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29160486/influence-of-therapeutic-play-on-the-anxiety-of-hospitalized-school-age-children-clinical-trial
#7
Sabrina Gisele Tobias da Silva, Maiara Aurichio Santos, Claudia Maria de Freitas Floriano, Elaine Buchhorn Cintra Damião, Fernanda Vieira de Campos, Lisabelle Mariano Rossato
OBJECTIVE: To evaluate the effects of Dramatic Therapeutic Play (DTP) technique on the degree of anxiety in hospitalized school-age children. METHOD: Randomized clinical trial performed in two hospitals ofSão Paulo, between May and October 2015. The intervention consisted of the application of DTP and the outcome was evaluated through the Child Drawing: Hospital (CD: H) instrument. The Wilcoxon-Mann Whitney, Corrected t, Fisher's exact and Chi-square tests were used in the analysis...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29160465/patient-satisfaction-with-pharmaceutical-services-in-brazilian-primary-health-care
#8
Orlando Mario Soeiro, Noêmia Urruth Leão Tavares, José Miguel do Nascimento, Augusto Afonso Guerra, Ediná Alves Costa, Francisco de Assis Acurcio, Ione Aquemi Guibu, Juliana Álvares, Margô Gomes de Oliveira Karnikowski, Silvana Nair Leite, Karen Sarmento Costa
OBJECTIVE: To evaluate patient satisfaction with pharmaceutical services in Brazilian primary health care. METHODS: This is a cross-sectional, exploratory, and evaluative study on a representative sample from the five Brazilian geopolitical regions resulting from the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015)...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160464/use-of-medicines-by-patients-of-the-primary-health-care-of-the-brazilian-unified-health-system
#9
Clarisse Melo Franco Neves Costa, Micheline Rosa Silveira, Francisco de Assis Acurcio, Augusto Afonso Guerra, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite, Ediná Alves Costa, Renata Cristina Rezende Macedo do Nascimento, Vânia Eloísa de Araújo, Juliana Álvares
OBJECTIVE: To characterize the use of medicines by patients of the primary health care of the Brazilian Unified Health System (SUS). METHODS: This is a cross-sectional, exploratory, and descriptive study, part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). Interviews were carried out with patients present in the services by semi-structured questionnaires...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160462/access-to-medicines-relations-with-the-institutionalization-of-pharmaceutical-services
#10
Rafael Damasceno de Barros, Ediná Alves Costa, Djanilson Barbosa Dos Santos, Gisélia Santana Souza, Juliana Álvares, Augusto Afonso Guerra, Francisco de Assis Acurcio, Ione Aquemi Guibu, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite
OBJETIVE: To analyze the relationship between access to medicines by the population and the institutionalization of pharmaceutical services in Brazilian primary health care. METHODS: This study is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services 2015), a cross-sectional, exploratory, and evaluative study composed of an information survey in a representative sample of cities, stratified by Brazilian regions...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160460/polypharmacy-a-challenge-for-the-primary-health-care-of-the-brazilian-unified-health-system
#11
Renata Cristina Rezende Macedo do Nascimento, Juliana Álvares, Augusto Afonso Guerra, Isabel Cristina Gomes, Micheline Rosa Silveira, Ediná Alves Costa, Silvana Nair Leite, Karen Sarmento Costa, Orlando Mario Soeiro, Ione Aquemi Guibu, Margô Gomes de Oliveira Karnikowski, Francisco de Assis Acurcio
OBJECTIVE: To characterize the polypharmacy in primary health care patients and to identify its associated factors. METHODS: This is a cross-sectional, exploratory, and evaluative study, part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). The variable of interest was polypharmacy, defined as the use of five or more medicines...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160459/characterization-of-the-institutionalization-of-pharmaceutical-services-in-brazilian-primary-health-care
#12
Gisélia Santana Souza, Ediná Alves Costa, Rafael Damasceno de Barros, Marcelo Tavares Pereira, Joslene Lacerda Barreto, Augusto Afonso Guerra, Francisco de Assis Acurcio, Ione Aquemi Guibu, Juliana Álvares, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite
OBJECTIVE: To characterize the current stage of the institutionalization of pharmaceutical services in Brazilian cities. METHODS: This study is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines), a cross-sectional, exploratory, and evaluative study composed by an information survey in a representative sample of cities, stratified by Brazilian regions...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160450/characterization-of-the-selection-of-medicines-for-the-brazilian-primary-health-care
#13
Margô Gomes de Oliveira Karnikowski, Dayani Galato, Micheline Marie Milward de Azevedo Meiners, Emília Vitória da Silva, Letícia Farias Gerlack, Ângelo José Gonçalves Bós, Silvana Nair Leite, Juliana Álvares, Ione Aquemi Guibu, Orlando Mario Soeiro, Karen Sarmento Costa, Ediná Alves Costa, Augusto Afonso Guerra, Francisco de Assis Acurcio
OBJECTIVE: To characterize the process of selection of medicines for primary health care in the Brazilian regions. METHODS: This article is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015), a cross-sectional study that consisted of an information gathering in a sample of cities in the five regions of Brazil...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160448/availability-of-essential-medicines-in-primary-health-care-of-the-brazilian-unified-health-system
#14
Renata Cristina Rezende Macedo do Nascimento, Juliana Álvares, Augusto Afonso Guerra, Isabel Cristina Gomes, Ediná Alves Costa, Silvana Nair Leite, Karen Sarmento Costa, Orlando Mario Soeiro, Ione Aquemi Guibu, Margô Gomes de Oliveira Karnikowski, Francisco de Assis Acurcio
OBJECTIVE: To characterize the availability of tracer medicines in pharmaceutical services in primary health care of the Brazilian Unified Health System (SUS). METHODS: This is a cross-sectional and evaluative study, part of the Pesquisa Nacional Sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015). To analyze the availability of medicines, we verified 50 items selected from the Relação Nacional de Medicamentos Essenciais (Rename - National List of Essential Medicines) of 2012...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160436/use-of-injected-heroin-and-risk-of-hepatitis-c-in-three-cities-in-colombia
#15
Dedsy Yajaira Berbesi-Fernández, Angela Maria Segura-Cardona, Liliana Patricia Montoya-Velez, Alexandra Ángel Santamaría
INTRODUCTION: Hepatitis C is one of the most neglected diseases by governments internationally. OBJECTIVE: Identify the prevalence of hepatitis C and associated injection drug users in three cities of factors Colombia. METHODS: Cross-sectional study of 668 injecting drug users recruited through respondent-driven sampling, inquired about demographic characteristics and risk behaviors. Laboratory testing was used on filter paper and cases of hepatitis C viral load tests with RNA were confirmed...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29160395/tooth-loss-in-patients-under-periodontal-maintenance-in-a-private-practice-a-retrospective-study
#16
Amanda Finger Stadler, Marina Mendez, Rui Vicente Oppermann, Sabrina Carvalho Gomes
The aim of the present study was to evaluate the incidence and causes of tooth loss in periodontal subjects from a private practice in Brazil. Two trained examiners extracted data from the records of subjects who sought periodontal treatment from 1980 to 2013. Only records of patients who completed the non-surgical periodontal treatment and had at least one visit for maintenance were included. Data were analyzed by chi-square test, Student's t-test, Kaplan-Meier survival curve and Cox regression. A total of 3,319 records were reviewed and 737 records included (58...
July 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29160383/epidemiological-trends-of-allergic-diseases-in-adolescents
#17
Silvia de Souza Campos Fernandes, Cláudia Ribeiro de Andrade, Cristina Gonçalves Alvim, Paulo Augusto Moreira Camargos, Cássio da Cunha Ibiapina
OBJECTIVE: To assess the prevalences of asthma, allergic rhinitis, and allergic rhinoconjunctivitis in adolescents in the city of Belo Horizonte, Brazil, in 2012 by administering the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, as well as to compare the observed prevalences with those found in studies performed 10 years earlier and employing the same methodology used here. METHODS: This was a cross-sectional study conducted between May and December of 2012 and involving adolescents in the 13- to 14-year age bracket...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29160231/hydrothermal-synthesis-of-stable-metallic-1t-phase-ws2-nanosheets-for-thermoelectric-application
#18
Mingxing Piao, Jin Chu, Xiao Wang, Yao Chi, Heng Zhang, Chaolong Li, Haofei Shi, Min-Kyu Joo
Two-dimensional (2D) materials have gained great attention as a promising thermoelectric (TE) material due to their unique density of state with confined electrons and holes. Here, we synthesized 1T phase tungsten disulfide (WS2) nanosheets with high TE performance via hydrothermal method. Flexible WS2 nanosheets restacked thin films were fabricated by employing vacuum filtration technique. The measured electrical conductivity was 45 S/cm with Seebeck coefficient of +30 μV/K at room temperature, indicating a p-type characteristic...
November 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29160004/urological-dysfunction-in-young-women-an-inheritance-of-childhood
#19
Elisabetta Costantini, Ester Illiano, Konstantinos Giannitsas, Marco Prestipino, Antonio Luigi Pastore, Antonio Carbone, Giovanni Palleschi, Raffaele Balsamo, Franca Natale, Donata Villari, Vittorio Bini, Serena Maruccia, Maria-Teresa Filocamo, Alessandro Zucchi
OBJECTIVE: To investigate the correlation of a history of lower urinary tract symptomatology during childhood to lower urinary tract dysfunction in young adult women. SUBJECTS/PATIENTS AND METHODS: This was a multicenter, prospective, case-control study conducted from April 2013 to November 2015. The trial was registered in ClinicalTrials. gov (NCT02185287). Three-hundred women, 18 to 40 years old, participated. Cases were women attending urogynecology clinics for various lower urinary tract complaints and controls were recruited from a healthy population...
November 21, 2017: BJU International
https://www.readbyqxmd.com/read/29159384/in-patients-with-proteinuric-iga-nephropathy-benefits-of-methylprednisolone-were-offset-by-harms
#20
Chi-Yuan Hsu
No abstract text is available yet for this article.
November 21, 2017: Annals of Internal Medicine
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