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https://www.readbyqxmd.com/read/29045717/interaction-between-calcium-and-potassium-modulates-elongation-rate-in-cotton-fiber-cells
#1
Kai Guo, Lili Tu, Yonghui He, Jinwu Deng, Maojun Wang, Hui Huang, Zhonghua Li, Xianlong Zhang, Miriam Gifford
Calcium (Ca2+) is necessary for fiber cell development in cotton (Gossypium hirsutum), both as a cell wall structural component and for environmental signaling responses. It is also known that potassium (K+) plays a critical role in cotton fiber cell elongation. However, it is unclear whether Ca2+ integrates its activities with K+ to regulate fiber elongation. Here, we report the novel discovery that Ca2+ deficiency, when integrated with K+ signaling, promotes fiber elongation. Using inductively coupled plasma-mass spectrometry (ICP-MS), we determined dynamic profiles of the ionome in ovules and fibers at different developmental stages, and found that a high accumulation of macro-elements, but not Ca2+, was associated with longer fibers...
October 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29045341/effect-of-antihypertensive-treatment-on-24-h-blood-pressure-variability-pooled-individual-data-analysis-of-ambulatory-blood-pressure-monitoring-studies-based-on-olmesartan-mono-or-combination-treatment
#2
Stefano Omboni, Kazuomi Kario, George Bakris, Gianfranco Parati
OBJECTIVE: To evaluate the impact of olmesartan alone or combined with one to three antihypertensive drugs on 24-h blood pressure variability (BPV) and on distribution of BP reduction in a pooled individual data analysis of 10 double-blind, randomized, ambulatory BP monitoring (ABPM) studies. METHODS: ABPMs were performed before and after 6-12 weeks of treatment with placebo (n = 119), active control monotherapy [n = 1195, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), dihydropyridine calcium channel blockers (DCCBs)], or DCCBs), olmesartan monotherapy (n = 1410), active control dual combination [n = 79, DCCB + thiazide diuretic (TD)], olmesartan dual combination (n = 637, DCCB or TD), and triple combination therapy (n = 102, DCCB+TD)...
October 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29045156/probing-the-interaction-mechanism-between-air-bubbles-and-bitumen-surfaces-in-aqueous-media-using-bubble-probe-afm
#3
Lei Xie, Chen Shi, Xin Cui, Jun Huang, Jingyi Wang, Qi Liu, Hongbo Zeng
Surface interactions involving deformable air bubbles have attracted tremendous interest in a wide range of engineering applications, such as mineral flotation and bitumen extraction. In this work, for the first time, the interaction forces between air bubbles and bitumen surfaces in complex aqueous media of varying pH, salinity and salts were directly measured using a bubble probe atomic force microscope (AFM) technique. The AFM topographic imaging reveals that bitumen surface tends to be rougher and form distinct domains at high NaCl concentration or under strongly alkaline environment...
October 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29045067/reconnectable-fiberscopes-for-chronic-in-vivo-deep-brain-imaging
#4
M S Pochechuev, I V Fedotov, O I Ivashkina, M A Roshchina, D V Meshchankin, D A Sidorov-Biryukov, A B Fedotov, K V Anokhin, A M Zheltikov
Reconnectable bundles consisting of thousands of optical fibers are shown to enable high-quality image transmission, offering a platform for the creation of implantable fiberscopes for minimally invasive in vivo brain imaging. Experiments on various lines of transgenic mice verify the performance of this fiberscope as a powerful tool for chronic in vivo neuroimaging using genetically encoded calcium indicators, neuronal activity markers, as well as axon growth regulators and brain-specific protein drivers in deep regions of live brain...
October 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29044948/intracellular-pathway-and-subsequent-transformation-of-hydroxyapatite-nanoparticles-in-the-saos-2-osteoblast-cell-line
#5
André L Rossi, Mariana M Longuinho, Marcelo N Tanaka, Marcos Farina, Radovan Borojevic, Alexandre M Rossi
Internalization of hydroxyapatite nanoparticles in SAOS-2 osteoblasts for 2 and 24 h was investigated in vitro using 5 and 50 µg/mL nanoparticles in culture medium. No cytotoxic effects were observed in a PrestoBlue viability assay. Focused ion beam-scanning electron microscopy and transmission electron microscopy were used to study nanoparticle trafficking inside cells and to characterize the physicochemical properties of the remodeled nanoparticles. Nanoparticles were actively internalized by cells and maintained in intracellular membrane-bound compartments...
October 17, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29043388/isolation-and-potential-biocementation-of-calcite-precipitation-inducing-bacteria-from-colombian-buildings
#6
Sandra M Montaño-Salazar, Juan Lizarazo-Marriaga, Pedro F B Brandão
Microbiological induced calcium carbonate or calcite precipitation (MICP) has become a highly researched issue due to its multiple applications in the construction industry, being a promising alternative with a great biotechnological importance. In this work, potential calcite precipitation inducing bacteria were isolated from mortar and concrete samples of different buildings at the National University of Colombia. Eighteen crystal-precipitating strains were recovered in Urea-CaCl2 solid medium. The 16S rRNA gene sequencing identified isolates as Arthrobacter, Psychrobacillus and Rhodococcus genera...
October 17, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29043222/production-of-fermented-kale-juices-with-lactobacillus-strains-and-nutritional-composition
#7
Seong Yeong Kim
Fermented kale juices using four types of lactobacilli were produced in the present study. After 48 h of fermentation time, viable cell counts of all ferments reached an above 10(9) CFU/mL. The viability of the ferments after cold storage in the refrigerator for 4 weeks showed 10(8) CFU/mL in all ferments. Among four types of fermented kale juices, the ferment of Lactobacillus acidophilus IFO 3025 indicated a good nutritional composition, including neutral sugar (1,909.76 μg/mL), reducing sugar (564.00 μg/mL, P<0...
September 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29042719/a-novel-conservative-approach-combining-sealbio-and-surgical-fenestration-for-healing-of-large-periapical-cystic-lesions-of-endodontic-origin-a-pilot-study
#8
Naseem Shah
OBJECTIVES: To evaluate the treatment outcome of large periapical cystic lesions treated by combining two novel, conservative approaches, "SealBio" and "Surgical Fenestration". MATERIALS AND METHODS: Five cases (4M:1F, age range 14-38 years, mean age 24.5 years) of large periapical cystic lesions, diagnosed on clinical and radiographic examination, were included in the study. After informed consent, endodontic treatment was initiated; chemo-mechanical preparation and intra-canal dressing of calcium hydroxide was given...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042501/plasmodium-falciparum-calcium-dependent-protein-kinase-2-is-critical-for-male-gametocyte-exflagellation-but-not-essential-for-asexual-proliferation
#9
Abhisheka Bansal, Alvaro Molina-Cruz, Joseph Brzostowski, Jianbing Mu, Louis H Miller
Drug development efforts have focused mostly on the asexual blood stages of the malaria parasite Plasmodium falciparum Except for primaquine, which has its own limitations, there are no available drugs that target the transmission of the parasite to mosquitoes. Therefore, there is a need to validate new parasite proteins that can be targeted for blocking transmission. P. falciparum calcium-dependent protein kinases (PfCDPKs) play critical roles at various stages of the parasite life cycle and, importantly, are absent in the human host...
October 17, 2017: MBio
https://www.readbyqxmd.com/read/29042322/activation-of-parvalbumin-neurons-in-the-rostro-dorsal-sector-of-the-thalamic-reticular-nucleus-promotes-sensitivity-to-pain-in-mice
#10
Jing Liu, Meng-Qi Zhang, Xu Wu, Michael Lazarus, Yoan Cherasse, Mao-Yun Yuan, Zhi-Li Huang, Rui-Xi Li
The calcium-binding protein, parvalbumin (PV), is highly expressed in thalamic reticular nucleus (TRN) GABAergic neurons, which receive input from the cerebral cortex and thalamus and send inhibitory output to the thalamic relay nucleus. Previous studies suggest that the TRN is involved in pain regulation as an important relay nucleus of the ascending pain pathway. However, little is known about its functional role in pain regulation and interconnectivity. In our study, the role of rostro-dorsal sector of TRN (TRNrd) PV-positive neurons in pain regulation was studied using chemogenetics based on designer receptors exclusively activated by designer drugs (DREADD)...
October 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/29042288/mast-cell-degranulation-and-calcium-influx-are-inhibited-by-an-echinacea-purpurea-extract-and-the-alkylamide-dodeca-2e-4e-dienoic-acid-isobutylamide
#11
Travis V Gulledge, Nicholas M Collette, Emily Mackey, Stephanie E Johnstone, Yasamin Moazami, Daniel A Todd, Adam J Moeser, Joshua G Pierce, Nadja B Cech, Scott M Laster
ETHNOPHARMACOLOGICAL RELEVANCE: Native Americans used plants from the genus Echinacea to treat a variety of different inflammatory conditions including swollen gums, sore throats, skin inflammation, and gastrointestinal disorders. Echinacea spp. produce many fatty acid amides referred to as alkylamides, which can inhibit cytokine, chemokine, and prostaglandin production from macrophages and T cells. Alkylamides are thought to contribute to the anti-inflammatory activity of E. purpurea extracts by inhibiting production of inflammatory mediators...
October 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29042253/calcium-uptake-and-cytochrome-c-release-from-normal-and-ischemic-brain-mitochondria
#12
Alexander Andreyev, Pratistha Tamrakar, Robert E Rosenthal, Gary Fiskum
At abnormally elevated levels of intracellular Ca(2+), mitochondrial Ca(2+) uptake may compromise mitochondrial electron transport activities and trigger membrane permeability changes that allow for release of cytochrome c and other mitochondrial apoptotic proteins into the cytosol. In this study, a clinically relevant canine cardiac arrest model was used to assess the effects of global cerebral ischemia and reperfusion on mitochondrial Ca(2+) uptake capacity, Ca(2+) uptake-mediated inhibition of respiration, and Ca(2+)-induced cytochrome c release, as measured in vitro in a K(+)-based medium in the presence of Mg(2+), ATP, and NADH-linked oxidizable substrates...
October 14, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29041879/-adherence-to-therapy-in-the-outpatient-setting-the-ability-to-identify-and-assess-the-effectiveness-of-therapy
#13
T F Ageev, D M Smirnova, D A Deev, V T Fofanova
AIM: To assess adherence of patients to antihypertensive therapy, to determine the role of various factors affecting adherence to treatment by outpatients, and to assess clinical efficacy of a calcium antagonist felodipine. MATERIAL AND METHODS: We examined 5 474 women and men aged >18 years who at visit to a local internist had office systolic arterial pressure (AP) 140-179 and diastolic AP up to 100 mm Hg both on and without hypotensive therapy. Examination included registration of risk factors and concomitant therapy...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29040737/calcium-driven-dna-synthesis-by-a-high-fidelity-dna-polymerase
#14
Céline Ralec, Etienne Henry, Mélanie Lemor, Tom Killelea, Ghislaine Henneke
Divalent metal ions, usually Mg2+, are required for both DNA synthesis and proofreading functions by DNA polymerases (DNA Pol). Although used as a non-reactive cofactor substitute for binding and crystallographic studies, Ca2+ supports DNA polymerization by only one DNA Pol, Dpo4. Here, we explore whether Ca2+-driven catalysis might apply to high-fidelity (HiFi) family B DNA Pols. The consequences of replacing Mg2+ by Ca2+ on base pairing at the polymerase active site as well as the editing of terminal nucleotides at the exonuclease active site of the archaeal Pyrococcus abyssi DNA Pol (PabPolB) are characterized and compared to other (families B, A, Y, X, D) DNA Pols...
October 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040452/assessment-of-vegetable-and-fruit-substrates-as-potential-rearing-media-for-hermetia-illucens-diptera-stratiomyidae-larvae
#15
Costanza Jucker, Daniela Erba, Maria Giovanna Leonardi, Daniela Lupi, Sara Savoldelli
Hermetia illucens (L.) (Diptera: Stratiomyidae) is able to consume a wide range of organic matter and is of particular interest for waste management. The nutritional value of preimaginal stages, in particular the protein content, makes this species a valid candidate for use as feed for other organisms. Vegetables and fruits are promising rearing substrates for insects produced for this purpose according to the EU regulation. In order to examine the effects of diets on insect performance and chemical composition, larvae were reared on the following substrates: 1) fruit (apple, pear, and orange); 2) vegetable (lettuce, green beans, and cabbage); and 3) mixed fruits and vegetables...
October 13, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29040219/effect-of-2-years-of-endurance-and-high-impact-training-on-preventing-osteoporosis-in-postmenopausal-women-randomized-clinical-trial
#16
Carmen García-Gomáriz, José M Blasco, Cecili Macián-Romero, Elías Guillem-Hernández, Celedonia Igual-Camacho
OBJECTIVE: The aim of the study was to analyze the effects of endurance and high-impact training oriented toward preventing osteoporosis in postmenopausal women with calcium and vitamin D supplementation. METHODS: This study was a randomized clinical trial. Thirty-six postmenopausal women were randomized to the control and experimental groups. Thirty-four women completed the 2-year interventions. The control group training involved walking at an intense pace. The experimental group conducted high-impact training specifically oriented to prevent osteoporosis...
October 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29039523/analysis-of-men1-c-482g-a-p-gly161asp-mutation-in-a-pedigree-with-familial-multiple-endocrine-neoplasia-type-1
#17
Yuanyuan Luo, Yongxiang Sun, Xiaofan Zhu, Xialian Li
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the development of neuroendocrine tumors, which in turn are caused by mutations in the MEN1 gene. In the present study, a case of a 46‑year‑old woman who was clinically diagnosed with MEN1 based on the presence of prolactinoma and bilateral parathyroid adenoma was reported. The patient's serum prolactin (PRL) levels were successfully controlled via bromocriptine therapy, and the serum levels of calcium and intact parathyroid hormone (PTH) reduced one day following parathyroidectomy...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039485/calcium-dobesilate-may-alleviate-diabetes%C3%A2-induced-endothelial-dysfunction-and-inflammation
#18
Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni
Diabetic kidney disease (DKD) is a leading cause of end‑stage renal disease. However, the pathogenesis of DKD remains unclear, and no effective treatments for the disease are available. Thus, there is an urgent need to elucidate the pathogenic mechanisms of DKD and to develop more effective therapies for this disease. Human umbilical vein endothelial cells (HUVECs) were cultured using different D‑glucose concentrations to determine the effect of high glucose (HG) on the cells. Alternatively, HUVECs were incubated with 100 µmol/l calcium dobesilate (CaD) to detect its effects...
October 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039452/molecular-analysis-of-keratocystic-odontogenic-tumor-cell-lines-derived-from-sporadic-and-basal-cell-nevus-syndrome-patients
#19
Kazuma Noguchi, Keiko Wakai, Tohru Kiyono, Mutsuki Kawabe, Kyohei Yoshikawa, Tomoko Hashimoto-Tamaoki, Hiromitsu Kishimoto, Yoshiro Nakano
Keratocystic odontogenic tumor (KCOT) is a benign tumor often associated with basal cell nevus syndrome (BCNS). Mutations in Patched 1 (PTCH1), the Hedgehog (Hh) receptor, are responsible for BCNS. BCNS is distinguished by morphological anomalies and predisposition to benign and malignant tumors, including medulloblastoma, basal cell carcinoma, KCOT and ovarian fibromas. Among these tumors, KCOT is the least well studied because a suitable model system is not available for its investigation. To enable KCOT to be studied, we established two KCOT cell lines, one from a BCNS case (designated as iKCOT1) and one from a sporadic KCOT case (designated as sKCOT1)...
October 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29038707/prevalence-of-idiopathic-hypercalciuria-in-children-with-urinary-system-related-symptoms-attending-a-pediatric-hospital-in-bandar-abbas-in-2014
#20
Maryam Esteghamati, Kambiz Ghasemi, Marie Nami
BACKGROUND: Idiopathic hypercalciuria is a group of diseases which can be manifested with urinary symptoms. Its importance is due to high prevalence, recurrent infections, and stone formations which are often asymptomatic. OBJECTIVE: The objective of this study was to determine the prevalence of idiopathic hypercalciuria in children with urinary system related symptoms in Bandar Abbas in 2014. METHODS: This descriptive cross-sectional study was done in 2014 in a children's hospital in Bandar Abbas (southern Iran) on 321 children who were between 2 months to 14 years old...
September 2017: Electronic Physician
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