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https://www.readbyqxmd.com/read/29916714/quantitative-proteomics-and-phosphoproteomics-analysis-revealed-different-regulatory-mechanisms-of-halothane-and-rendement-napole-genes-in-porcine-muscle-metabolism
#1
Honggang Huang, Tracy L Scheffler, David E Gerrard, Martin R Larsen, Rene Lametsch
Pigs with the Halothane (HAL) and/or Rendement Napole (RN) gene mutations demonstrate abnormal muscle energy metabolism patterns and produce meat with poor quality, classified as pale, soft and exudative (PSE) meat, but it is not well understood how HAL and RN mutations regulate glucose and energy metabolism in porcine muscle. In order to investigate the potential signaling pathways and phosphorylation events related to these mutations, muscle samples were collected from four genotypes of pigs: wildtype, RN, HAL and RN-HAL double mutations and subjected to quantitative proteomic and phosphoproteomic analysis using the TiO2 enrichment strategy...
June 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29916398/feasibility-study-for-a-glutamate-driven-subretinal-prosthesis-local-subretinal-application-of-glutamate-on-blind-retina-evoke-network-mediated-responses-in-different-types-of-ganglion-cells
#2
Wadood Haq, Johannes Dietter, Sylvia Bolz, Eberhart Zrenner
OBJECTIVE: A feasibility study for a transmitter based subretinal prosthesis, generating visual responses in blind mouse retina is presented. APPROACH: Degenerated rd1 mouse retina were stimulated in subretinal configuration by local glutamate (Glu) or NMDA application via micropipettes (~1.5 μm) and thereby the outer retinal activity was recorded by calcium-imaging or the ganglion cell (GC) activity was recorded by the multi-electrode array system. The network mediated activation of GC via bipolar cells was approved by the administration of Glu receptor blockers...
June 19, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29916137/high-serum-osteopontin-levels-are-associated-with-prevalent-fractures-and-worse-lipid-profile-in-post-menopausal-women-with-type-2-diabetes
#3
T Filardi, V Carnevale, R Massoud, C Russo, L Nieddu, F Tavaglione, I Turinese, A Lenzi, E Romagnoli, S Morano
PURPOSE: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM. METHODS: Sixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3...
June 18, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29915850/a-descriptive-study-of-vitamin-d-and-other-nutritional-factors-in-breast-cancer-patients-in-saudi-arabia
#4
Nora A AlFaris, Nora M ALkehayez, Fatema I AlMushawah, AbdulRhman N Al Naeem, Nadia D Al-Amri, Ebtisam S Almudawah
OBJECTIVES: To assess the role of serum vitamin D and other nutritional factors in women with breast cancer in Saudi. METHODS: A total of 500 women (250 patients with breast cancer and 250 controls) aged 30-60 years were recruited from King Saud Medical City and King Fahad Medical City, Riyadh, Saudi Arabia,  between May 2015 and June 2016. In this cross-sectional study, blood pressure, plasma concentrations of vitamin D, and calcium levels were evaluated. A 3-day dietary record was used to assess dietary intake...
June 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29914556/occurrence-of-health-compromising-protozoan-and-helminth-infections-in-tortoises-kept-as-pet-animals-in-germany
#5
Malek J Hallinger, Anja Taubert, Carlos Hermosilla, Frank Mutschmann
BACKGROUND: Exotic reptiles such as tortoises, have become increasingly common domestic pets worldwide and are known to host different gastrointestinal parasites. Some of these parasites bear zoonotic potential. In the present survey, we parasitologically examined tortoise faecal samples (n = 1005) from 19 different species held as pets in private German households and German zoological gardens. METHODS: Saline faecal smears were used to generate prevalence data for potentially health-compromising gastrointestinal parasites...
June 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29914160/-bordetella-pertussis-adenylate-cyclase-toxin-does-not-possess-a-phospholipase-a-activity-serine-606-and-aspartate-1079-residues-are-not-involved-in-target-cell-delivery-of-the-adenylyl-cyclase-enzyme-domain
#6
Ladislav Bumba, Jiri Masin, Adriana Osickova, Radim Osicka, Peter Sebo
The adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) plays a crucial role in virulence and airway colonization capacity of the whooping cough agent Bordetella pertussis . The toxin penetrates target cell membranes and exhibits three distinct biological activities. A population of CyaA conformers forms small cation-selective pores that permeabilize the cell membrane for potassium efflux, which can provoke colloid-osmotic (oncotic) cell lysis. The other two activities are due to CyaA conformers that transiently form calcium influx conduits in the target cell membrane and translocate the adenylate cyclase (AC) enzyme into cytosol of cells...
June 16, 2018: Toxins
https://www.readbyqxmd.com/read/29914106/annexins-in-translational-research-hidden-treasures-to-be-found
#7
REVIEW
Sebastian Schloer, Denise Pajonczyk, Ursula Rescher
The vertebrate annexin superfamily (AnxA) consists of 12 members of a calcium (Ca2+ ) and phospholipid binding protein family which share a high structural homology. In keeping with this hallmark feature, annexins have been implicated in the Ca2+ -controlled regulation of a broad range of membrane events. In this review, we identify and discuss several themes of annexin actions that hold a potential therapeutic value, namely, the regulation of the immune response and the control of tissue homeostasis, and that repeatedly surface in the annexin activity profile...
June 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29914013/high-doses-of-erythropoietin-stimulating-agents-may-be-a-risk-factor-for-av-fistula-stenosis
#8
Anna Wärme, Ursula Hadimeri, Henrik Hadimeri, Salmir Nasic, Bernd Stegmayr
BACKGROUND: A native AV-fistula (AVF) for access in hemodialysis (HD) is preferable. Stenosis, a major hurdle, is associated with older age and diabetes mellitus. PURPOSE: This case-control study aimed to clarify if any medical and/or laboratory factors, that can be altered, could be associated to AVF stenosis. METHODS: 33 patients with a patent AVF without need of intervention during a two year period (Controls) were matched by diagnosis and age with 33 patients (Cases), that had at least one radiological invasive examination/intervention due to suspected AVF malfunction (case-control mode 2:1)...
June 9, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29913186/blockade-of-t-type-calcium-channels-by-6-prenylnaringenin-a-hop-component-alleviates-neuropathic-and-visceral-pain-in-mice
#9
Fumiko Sekiguchi, Tomoyo Fujita, Takahiro Deguchi, Sakura Yamaoka, Ken Tomochika, Maho Tsubota, Sumire Ono, Yamato Horaguchi, Maki Ichii, Mio Ichikawa, Yumiko Ueno, Nene Koike, Tadatoshi Tanino, Huy Du Nguyen, Takuya Okada, Hiroyuki Nishikawa, Shigeru Yoshida, Tsuyako Ohkubo, Naoki Toyooka, Kazuya Murata, Hideaki Matsuda, Atsufumi Kawabata
Since Cav 3.2 T-type Ca2+ channels (T-channels) expressed in the primary afferents and CNS contribute to intractable pain, we explored T-channel-blocking components in distinct herbal extracts using a whole-cell patch-clamp technique in HEK293 cells stably expressing Cav 3.2 or Cav 3.1, and purified and identified sophoraflavanone G (SG) as an active compound from SOPHORAE RADIX (SR). Interestingly, hop-derived SG analogues, (2S)-6-prenylnaringenin (6-PNG) and (2S)-8-PNG, but not naringenin, also blocked T-channels; IC50 (μM) of SG, (2S)-6-PNG and (2S)-8-PNG was 0...
June 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29912988/severe-secondary-hyperparathyroidism-in-patients-on-haemodialysis-is-associated-with-a-high-initial-serum-parathyroid-hormone-and-beta-crosslaps-level-results-from-an-incident-cohort
#10
Guillaume Jean, Marie Hélène Lafage-Proust, Jean Claude Souberbielle, Sylvain Lechevallier, Patrik Deleaval, Christie Lorriaux, Jean Marc Hurot, Brice Mayor, Manolie Mehdi, Charles Chazot
BACKGROUND: Secondary hyperparathyroidism (SHPT) is a frequent complication of renal disease and most commonly occurs in patients on haemodialysis (HD) with metabolic, vascular, endocrine, and bone complications. The aim of this study was to analyze the evolution of mineral metabolism parameters during the first 36 months of HD treatment and identify the initial factors associated with severe SHPT. METHODS: Serum parathyroid hormone (PTH), calcium and phosphate levels were measured monthly; bone-specific alkaline phosphatase (b-ALP) and beta-CrossLaps (CTX) were measured biannually...
2018: PloS One
https://www.readbyqxmd.com/read/29912941/structural-definition-of-hsp-d-recognition-of-salmonella-enterica-lps-inner-core-oligosaccharides-reveals-alternative-binding-modes-for-the-same-lps
#11
Jamie R Littlejohn, Ruben F da Silva, William A Neale, Carrie C Smallcombe, Howard W Clark, Rose-Marie A Mackay, Alastair S Watson, Jens Madsen, Derek W Hood, Ian Burns, Trevor J Greenhough, Annette K Shrive
The crystal structures of a biologically and therapeutically active recombinant homotrimeric fragment of native human SP-D (hSP-D) complexed with the inner core oligosaccharide of the Salmonella enterica sv Minnesota rough strains R5 and R7 (rough mutant chemotypes Rc and Rd1) have been determined. The structures reveal that hSP-D specifically and preferentially targets the LPS inner core via the innermost conserved Hep-Kdo pair with the flexibility for alternative recognition when this preferred epitope is not available for binding...
2018: PloS One
https://www.readbyqxmd.com/read/29912414/peroxiredoxin-6-is-the-primary-antioxidant-enzyme-for-the-maintenance-of-viability-and-dna-integrity-in-human-spermatozoa
#12
Maria C Fernandez, Cristian O'Flaherty
STUDY QUESTION: Are all components of the peroxiredoxins (PRDXs) system important to control the levels of reactive oxygen species (ROS) to maintain viability and DNA integrity in spermatozoa? SUMMARY ANSWER: PRDX6 is the primary player of the PRDXs system for maintaining viability and DNA integrity in human spermatozoa. WHAT IS KNOWN ALREADY: Mammalian spermatozoa are sensitive to high levels of ROS and PRDXs are antioxidant enzymes proven to control the levels of ROS generated during sperm capacitation to avoid oxidative damage in the spermatozoon...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29910739/effects-of-dietary-phosphorus-level-on-the-expression-of-calcium-and-phosphorus-transporters-in-laying-hens
#13
Peng Li, Rongmei Wang, Hongchao Jiao, Xiaojuan Wang, Jingpeng Zhao, Hai Lin
The transport of calcium and phosphorus is mainly relied on their corresponding transporters. The aim of this study was to determine the effect of dietary phosphorus level on the expression of the relevant calcium and phosphorus transporters in laying hens, which has a large amount of calcium and phosphorus input from intestine and output from kidney and eggshell gland. Thirty-six 25-week-old Hy-line Brown hens were fed diets with different available phosphorus level (AP, 0.15, 0.41, and 0.82%), respectively...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29910405/energy-expenditure-availability-and-dietary-intake-assessment-in-competitive-female-dragon-boat-athletes
#14
Jun Liang Ong, Iain A Brownlee
Dragon boat racing requires high physical activity levels during competition and training. The female athletic triad refers to a number of negative health consequences (e.g., amenorrhoea, low bone mineral density, and low energy availability) that may result from high physical activity in female athletes in parallel with inadequate dietary intake. This study aimed to estimate energy expenditure and dietary adequacy in female competitive dragon boat athletes. Following ethical approval, energy expenditure was assessed by use of SensewearTM armbands (which measure movement as well as galvanic heat loss) on nine dragon boat athletes preparing for the Southeast Asian Games 2013...
June 21, 2017: Sports
https://www.readbyqxmd.com/read/29910073/activity-dependent-actin-remodeling-at-the-base-of-dendritic-spines-promotes-microtubule-entry
#15
Philipp Schätzle, Marta Esteves da Silva, Roderick P Tas, Eugene A Katrukha, Hai Yin Hu, Corette J Wierenga, Lukas C Kapitein, Casper C Hoogenraad
In neurons, microtubules form dense bundles and run along the length of axons and dendrites. Occasionally, dendritic microtubules can grow from the shaft directly into dendritic spines. Microtubules target dendritic spines that are undergoing activity-dependent changes, but the mechanism by which microtubules enter spines has remained poorly understood. Using live-cell imaging, high-resolution microscopy, and local glutamate uncaging, we show that local actin remodeling at the base of a spine promotes microtubule spine targeting...
June 5, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29909574/the-possible-antidiabetic-effects-of-vitamin-d-receptors-agonist-in-rat-model-of-type-2-diabetes
#16
Wafaa M Abdel-Rehim, Rasha A El-Tahan, Mennatullah A El-Tarawy, Rowaida R Shehata, Maher A Kamel
Vitamin D3 deficiency was found to be tightly linked to many health problems including metabolic syndrome, cancer, cardiovascular diseases, and type 2 diabetes mellitus. In our study, we tested the possible antidiabetic effects of one of vitamin D3 analogs, alfacalcidol, solely or in a combination with metformin on type 2 diabetic rats. Type 2 diabetic model rats were induced by feeding high-fat diet for 4 weeks followed by intraperitoneal injection of streptozotocin. In addition to the control group, the diabetic rats were divided into four groups: untreated, metformin-treated, alfacalcidol-treated, and combination-treated group (metformin + alfacalcidol) for 4 weeks...
June 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29909404/aortic-arch-width-and-cardiovascular-disease-in-men-and-women-in-the-community
#17
Michael L Chuang, Philimon N Gona, Saadia Qazi, Rebecca M Musgrave, Caroline S Fox, Joseph M Massaro, Udo Hoffmann, Christopher J O'Donnell
BACKGROUND: We sought to determine whether increased aortic arch width (AAW) adds to standard Framingham risk factors and coronary artery calcium (CAC) for prediction of incident adverse cardiovascular disease (CVD) events in community-dwelling adults. METHODS AND RESULTS: A total of 3026 Framingham Heart Study Offspring and Third Generation cohort participants underwent noncontrast multidetector computed tomography from 2002 to 2005 to quantify CAC. We measured AAW as the distance between the centroids of the ascending and descending thoracic aorta, at the level of main pulmonary artery bifurcation or the right pulmonary artery...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909312/icariin-loaded-electrospun-pcl-gelatin-nanofiber-membrane-as-potential-artificial-periosteum
#18
Min Gong, Cheng Chi, Jingjing Ye, Meihong Liao, Wenqi Xie, Chengai Wu, Rui Shi, Liqun Zhang
Due to the significant role of the periosteum in bone regeneration, we hypothesised that using a specially engineered artificial periosteum could lead to an enhancement in osteogenesis in bone grafts. Herein, we describe our work aimed at fabricating an electrospun fibrous membrane as an artificial periosteum that exhibits flexibility, permeability and osteoinduction. This membrane was designed to cover the complex surface of bone grafts to facilitate and accelerate bone regeneration. The traditional Chinese medicine icariin (ICA) was subsequently introduced into poly (ε-caprolactone) (PCL) /gelatin nanofibers to fabricate an artificial periosteum for the first time...
June 14, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29908962/targeting-orai1-mediated-store-operated-calcium-entry-by-rp4010-for-anti-tumor-activity-in-esophagus-squamous-cell-carcinoma
#19
Chaochu Cui, Yan Chang, Xiaoli Zhang, Sangyong Choi, Henry Tran, Kumar V Penmetsa, Srikant Viswanadha, Liwu Fu, Zui Pan
Esophageal cancer (EC) is the 6 t h leading cause of cancer mortality worldwide with poor prognosis, hence more effective chemotherapeutic drugs for this deadly disease are urgently needed. We previously reported that high expression of Orai1, a store-operated Ca2+ entry (SOCE) channel was associated with poor survival rate in EC patients and Orai1-mediated intracellular Ca2+ oscillations regulated cancer cell proliferation. Previous studies suggested that Orai1-mediated SOCE is a promising target for EC chemotherapy...
June 14, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29908490/identification-characterization-and-expression-analysis-of-calmodulin-and-calmodulin-like-genes-in-grapevine-vitis-vinifera-reveal-likely-roles-in-stress-responses
#20
Elodie Vandelle, Alessandro Vannozzi, Darren Wong, Davide Danzi, Anne-Marie Digby, Silvia Dal Santo, Alessandra Astegno
Calcium (Ca2+ ) is an ubiquitous key second messenger in plants, where it modulates many developmental and adaptive processes in response to various stimuli. Several proteins containing Ca2+ binding domain have been identified in plants, including calmodulin (CaM) and calmodulin-like (CML) proteins, which play critical roles in translating Ca2+ signals into proper cellular responses. In this work, a genome-wide analysis conducted in Vitis vinifera identified three CaM- and 62 CML-encoding genes. We assigned gene family nomenclature, analyzed gene structure, chromosomal location and gene duplication, as well as protein motif organization...
June 4, 2018: Plant Physiology and Biochemistry: PPB
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