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https://www.readbyqxmd.com/read/28929327/possible-long-term-efficacy-of-sitagliptin-a-dipeptidyl-peptidase-4-inhibitor-for-slowly-progressive-type-1-diabetes-spiddm-in-the-stage-of-non-insulin-dependency-an-open-label-randomized-controlled-pilot-trial-span-s
#1
Takuya Awata, Akira Shimada, Taro Maruyama, Yoichi Oikawa, Nobuyuki Yasukawa, Susumu Kurihara, Yumi Miyashita, Masako Hatano, Yuichi Ikegami, Masafumi Matsuda, Masataka Niwa, Youichiro Kazama, Shoichiro Tanaka, Tetsuro Kobayashi
INTRODUCTION: We tested the hypothesis that dipeptidyl peptidase-4 (DPP-4) inhibitors are effective in preserving the β-cell function for long-term periods in patients with slowly progressive type 1 diabetes (SPIDDM) or latent autoimmune diabetes in adults (LADA). METHODS: In the present open-label, randomized, controlled trial, 14 non-insulin-requiring diabetic patients with glutamic acid decarboxylase autoantibodies (GADAb) were randomly assigned to receive either sitagliptin (S group) or pioglitazone (P group)...
September 19, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28928286/hpv-integration-in-hnscc-correlates-with-survival-outcomes-immune-response-signatures-and-candidate-drivers
#2
Lada A Koneva, Yanxiao Zhang, Shama Virani, Pelle B Hall, Jonathan B McHugh, Douglas B Chepeha, Gregory Wolf, Thomas E Carey, Laura S Rozek, Maureen A Sartor
The incidence of human papillomavirus (HPV)-related oropharynx cancer has steadily increased over the past two decades, and now represents a majority of oropharyngeal cancer cases. Integration of the HPV genome into the host genome is a common event during carcinogenesis that has clinically-relevant effects if the viral early genes are transcribed. Understanding the impact of HPV integration on clinical outcomes of head and neck squamous cell carcinoma (HNSCC) is critical for implementing de-escalated treatment approaches for HPV-positive HNSCC patients...
September 19, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28923382/synthesis-and-biological-evaluation-of-new-substituted-thioglycolurils-their-analogues-and-derivatives
#3
Galina A Gazieva, Lada V Anikina, Tatyana V Nechaeva, Sergey A Pukhov, Tatyana B Karpova, Sergey V Popkov, Yulia V Nelyubina, Natalya G Kolotyrkina, Angelina N Kravchenko
A novel series of substituted N-aminothioglycolurils was synthesized by tandem hydrazone formation - ring contraction reaction of 3-thioxoperhydroimidazo[4,5-e]-1,2,4-triazin-6-ones with (E)-3-phenyl(furan-2-yl)acrylaldehyde derivatives. S-Alkyl substituted N-aminothioglycolurils were prepared through alkylation of corresponding thioglycolurils with iodoalkane or 4-chlorobenzylchloride. Methylthio group in S-methyl derivatives can be substituted with hydroxyl group in acid medium to give N-aminoglycolurils...
September 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28906277/effect-of-cytomegalovirus-and-epstein-barr-virus-replication-on-intestinal-mucosal-gene-expression-and-microbiome-composition-of-hiv-infected-and-uninfected-individuals
#4
Sara Gianella, Antoine Chaillon, Ece A Mutlu, Phillip A Engen, Robin M Voigt, Ali Keshavarzian, John Losurdo, Prachi Chakradeo, Steven M Lada, Masato Nakazawa, Alan L Landay
BACKGROUND: HIV-infection is associated with dramatic changes in the intestinal mucosa. The impact of other viral pathogens is unclear. METHODS: One hundred and eight (108) biopsies from left and right colon (n = 79) and terminal ileum (n = 29) were collected from 19 HIV-infected and 22 HIV-uninfected participants. Levels of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNA were measured by droplet digital PCR. Mucosal gene expression was measured via multiplex-assay...
September 24, 2017: AIDS
https://www.readbyqxmd.com/read/28885622/adult-onset-autoimmune-diabetes-current-knowledge-and-implications-for-management
#5
REVIEW
Raffaella Buzzetti, Simona Zampetti, Ernesto Maddaloni
Adult-onset autoimmune diabetes is a heterogeneous disease that is characterized by a reduced genetic load, a less intensive autoimmune process and a mild metabolic decompensation at onset compared with young-onset type 1 diabetes mellitus (T1DM). The majority of patients with adult-onset autoimmune diabetes do not require insulin treatment for at least 6 months after diagnosis. Such patients are defined as having latent autoimmune diabetes in adults (LADA), which is distinct from classic adult-onset T1DM. The extensive heterogeneity of adult-onset autoimmune diabetes is apparent beyond the distinction between classic adult-onset T1DM and LADA...
September 8, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28884366/weather-conditions-a-neglected-factor-in-human-salivary-cortisol-research
#6
Goran Milas, Daniela Šupe-Domić, Irena Drmić-Hofman, Lada Rumora, Irena Martinović Klarić
There is ample evidence that environmental stressors such as extreme weather conditions affect animal behavior and that this process is in part mediated through the elevated activity of the hypothalamic pituitary adrenal axis which results in an increase in cortisol secretion. This relationship has not been extensively researched in humans, and weather conditions have not been analyzed as a potential confounder in human studies of stress. Consequently, the goal of this paper was to assess the relationship between salivary cortisol and weather conditions in the course of everyday life and to test a possible moderating effect of two weather-related variables, the climate region and timing of exposure to outdoors conditions...
September 7, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28869413/severe-oesophageal-disease-and-its-associations-with-systemic-sclerosis
#7
Georgios P Karamanolis, Konstantinos Denaxas, Stylianos Panopoulos, Kalliopi-Vasiliki Bournia, Alexandra Zorbala, Dimitrios Kamberoglou, Dimitrios Schizas, Spiros D Ladas, Petros P Sfikakis
OBJECTIVES: Severe oesophageal disease in patients with systemic sclerosis (SSc), referred as scleroderma oesophagus, is characterised by ineffective or absent peristalsis along with hypotensive oesophagogastric junction (hEGJ). The associations between scleroderma oesophagus and different clinical and laboratory manifestations of SSc is still controversial. In this study we aimed to assess associations between scleroderma oesophagus, diagnosed by high resolution manometry (HRM), and other manifestations of disease...
August 30, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28857443/metabolic-and-stress-responses-of-acinetobacter-oleivorans-dr1-during-long-chain-alkane-degradation
#8
Chulwoo Park, Bora Shin, Jaejoon Jung, Yunho Lee, Woojun Park
Acinetobacter oleivorans DR1 can utilize C12 -C30 alkanes as a sole carbon source but not short-chain alkanes (C6 , C10 ). Two copies of each alkB-, almA- and ladA-type alkane hydroxylase (AH) are present in the genome of DR1 cells. Expression and mutational analyses of AHs showed that alkB1 and alkB2 are the major AH-encoding genes under C12 -C30 , and the roles of other almA- and ladA genes are negligible. Our data suggested that AlkB1 is responsible for long-chain alkane utilization (C24 -C26 ), and AlkB2 is important for medium-chain alkane (C12 -C16 ) metabolism...
August 31, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28830607/partnership-of-the-sociedade-brasileira-de-oncologia-pedi%C3%A3-trica-and-international-society-of-pediatric-oncology-to-improve-nutritional-care-for-children-with-cancer-in-brazil
#9
Karina Viani, Vicente Odone Filho, Sima Ferman, Teresa Cristina Cardoso Fonseca, Vanessa da Cunha Oliveira, Priscila Dos Santos Maia Lemos, Ronald D Barr, Elena J Ladas
The authors present a proposal of a partnership between the Sociedade Brasileira de Oncologia Pediátrica (SOBOPE) and the International Society of Pediatric Oncology (SIOP) to promote the standardization and improvement of nutritional care of kids under cancer treatment in Brazil. The results of the first meeting in Brazil as well as plans for future meetings are described.
July 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28816728/lipid-deposition-on-contact-lenses-when-using-contemporary-care-solutions
#10
RANDOMIZED CONTROLLED TRIAL
Negar Babaei Omali, Mark Lada, Carol Lakkis, Philip B Morgan, Jason J Nichols, Lakshman N Subbaraman, Lyndon W Jones
SIGNIFICANCE: There remains only a small amount of data from human studies demonstrating the effect of contact lens/lens care solution combinations on the deposition of lipids. Therefore, information on the degree to which modern materials deposit lipids when used with contemporary care solutions would be valuable. PURPOSE: The present study aims to determine the effect of lens care system combinations on levels of total lipid, cholesterol, and cholesteryl esters extracted from three different contact lenses (CLs) when used with four contemporary care systems...
September 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28813492/point-prevalence-survey-of-healthcare-facility-onset-healthcare-associated-clostridium-difficile-infection-in-greek-hospitals-outside-the-intensive-care-unit-the-c-define-study
#11
Athanasios Skoutelis, Angelos Pefanis, Sotirios Tsiodras, Nikolaos V Sipsas, Moyssis Lelekis, Marios C Lazanas, Panagiotis Gargalianos, George N Dalekos, Emmanuel Roilides, George Samonis, Efstratios Maltezos, Dimitrios Hatzigeorgiou, Malvina Lada, Symeon Metallidis, Athena Stoupis, Georgios Chrysos, Lazaros Karnesis, Styliani Symbardi, Chariclia V Loupa, Helen Giamarellou, Ioannis Kioumis, Helen Sambatakou, Epameinondas Tsianos, Maria Kotsopoulou, Areti Georgopali, Klairi Liakou, Stavroula Perlorentzou, Stamatina Levidiotou, Marina Giotsa-Toutouza, Helen Tsorlini-Christoforidou, Ilias Karaiskos, Georgia Kouppari, Eleftheria Trikka-Graphakos, Maria-Anna Ntrivala, Kate Themeli-Digalaki, Anastasia Pangalis, Melina Kachrimanidou, Maria Martsoukou, Stergios Karapsias, Maria Panopoulou, Sofia Maraki, Anagnostina Orfanou, Efthymia Petinaki, Maria Orfanidou, Vasiliki Baka, Antonios Stylianakis, Iris Spiliopoulou, Stavroula Smilakou, Loukia Zerva, Evangelos Vogiatzakis, Eleni Belesiotou, Charalambos A Gogos
BACKGROUND: The correlation of Clostridium difficile infection (CDI) with in-hospital morbidity is important in hospital settings where broad-spectrum antimicrobial agents are routinely used, such as in Greece. The C. DEFINE study aimed to assess point-prevalence of CDI in Greece during two study periods in 2013. METHODS: There were two study periods consisting of a single day in March and another in October 2013. Stool samples from all patients hospitalized outside the ICU aged ≥18 years old with diarrhea on each day in 21 and 25 hospitals, respectively, were tested for CDI...
2017: PloS One
https://www.readbyqxmd.com/read/28808034/feedback-amplification-loop-drives-malignant-growth-in-epithelial-tissues
#12
Mariana Muzzopappa, Lada Murcia, Marco Milán
Interactions between cells bearing oncogenic mutations and the surrounding microenvironment, and cooperation between clonally distinct cell populations, can contribute to the growth and malignancy of epithelial tumors. The genetic techniques available in Drosophila have contributed to identify important roles of the TNF-α ligand Eiger and mitogenic molecules in mediating these interactions during the early steps of tumor formation. Here we unravel the existence of a tumor-intrinsic-and microenvironment-independent-self-reinforcement mechanism that drives tumor initiation and growth in an Eiger-independent manner...
August 29, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28795821/fast-hole-tunneling-times-in-germanium-hut-wires-probed-by-single-shot-reflectometry
#13
Lada Vukušić, Josip Kukučka, Hannes Watzinger, Georgios Katsaros
Heavy holes confined in quantum dots are predicted to be promising candidates for the realization of spin qubits with long coherence times. Here we focus on such heavy-hole states confined in germanium hut wires. By tuning the growth density of the latter we can realize a T-like structure between two neighboring wires. Such a structure allows the realization of a charge sensor, which is electrostatically and tunnel coupled to a quantum dot, with charge-transfer signals as high as 0.3 e. By integrating the T-like structure into a radiofrequency reflectometry setup, single-shot measurements allowing the extraction of hole tunneling times are performed...
September 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28783541/increasing-frequency-of-non-smoking-lung-cancer-presentation-of-patients-with-early-disease-to-a-tertiary-institution-in-the-uk
#14
Maria Elena Cufari, Chiara Proli, Paulo De Sousa, Hilgardt Raubenheimer, May Al Sahaf, Hema Chavan, Lynn Shedden, Zakiyah Niwaz, Maria Leung, Andrew G Nicholson, Vladimir Anikin, Emma Beddow, Niall McGonigle, Michael E Dusmet, Simon Jordan, George Ladas, Eric Lim
BACKGROUND: Never-smokers with lung cancer often present late as there are no established aetiological risk factors. The aim of the study is to define the frequency over time and characterise clinical features of never-smokers presenting sufficiently early to determine if it is possible to identify patients at risk. METHODS: We retrospectively analysed data from a prospectively collected database of patients who underwent surgery. The frequency was defined as number of never-smokers versus current and ex-smokers by year...
August 3, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28761648/education-immigration-and-income-as-risk-factors-for-hemoglobin-a1c-70-mmol-mol-when-diagnosed-with-type-2-diabetes-or-latent-autoimmune-diabetes-in-adult-a-population-based-cohort-study
#15
Mats Martinell, Ronnie Pingel, Johan Hallqvist, Mozhgan Dorkhan, Leif Groop, Anders Rosengren, Petter Storm, Jan Stålhammar
OBJECTIVES: The aim of this research is to study education, income and immigration as risk factors for high hemoglobin A1c (HbA1c >70 mmol/mol (8.6%)) when diagnosed with type 2 diabetes (T2D) or latent autoimmune diabetes in the adult (LADA). RESEARCH DESIGN AND METHODS: Patients were included from the All New Diabetics in Scania study (2008-2013). Level of education, disposable income and immigration year were retrieved from the longitudinal integrated database for labour market research (LISA) register compiled by Statistics Sweden...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28750634/preclinical-carotid-atherosclerosis-in-patients-with-latent-autoimmune-diabetes-in-adults-lada-type-2-diabetes-and-classical-type-1-diabetes
#16
Marta Hernández, Carolina López, Jordi Real, Joan Valls, Emilio Ortega-Martinez de Victoria, Federico Vázquez, Esther Rubinat, Minerva Granado-Casas, Nuria Alonso, Teresa Molí, Angels Betriu, Albert Lecube, Elvira Fernández, Richard David Leslie, Dídac Mauricio
BACKGROUND: LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes. METHODS: Patients with LADA were matched for age and gender in different proportions to patients with type 2 diabetes, and classic type 1 diabetes...
July 28, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28694083/impact-of-surface-functionalization-on-the-uptake-mechanism-and-toxicity-effects-of-silver-nanoparticles-in-hepg2-cells
#17
Lada Brkić Ahmed, Mirta Milić, Igor M Pongrac, Ana Marija Marjanović, Hrvoje Mlinarić, Ivan Pavičić, Srećko Gajović, Ivana Vinković Vrček
Safe and successful bioapplications of metallic nanoparticles depend on their physicochemical characteristics, in particular their surface properties. This study aimed to investigate how different surface functionalization of silver nanoparticles (AgNP) affect their interaction with mammalian liver cells with regard to cytotoxicity, genotoxicity and mechanism of cellular uptake. Differentially coated AgNP were prepared by surface functionalization using sodium bis(2-ethylhexyl)-sulfosuccinate (AOTAgNP), cetyltrimethylammonium bromide (CTABAgNP), poly(vinylpyrrolidone) (PVPAgNP), poly-l-lysine (PLLAgNP), and bovine serum albumin (BSAAgNP)...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28692535/effect-of-cmv-and-ebv-replication-on-intestinal-mucosal-gene-expression-and-microbiome-composition-of-hiv-infected-and-uninfected-individuals
#18
Sara Gianella, Antoine Chaillon, Ece A Mutlu, Phillip A Engen, Robin M Voigt, Ali Keshavarzian, John Losurdo, Prachi Chakradeo, Steven M Lada, Masato Nakazawa, Alan L Landay
BACKGROUND: HIV-infection is associated with dramatic changes in the intestinal mucosa. The impact of other viral pathogens is unclear. METHODS: Eighty biopsies from left and right colon (n=63) and terminal ileum (n = 17) were collected from 19 HIV-infected and 22 HIV-uninfected subjects. Levels of cytomegalovirus (CMV) and Epstein Barr Virus (EBV) DNA were measured by droplet-digital (dd)PCR. Mucosal gene expression was measured via multiplex-assay. Microbiome analysis was performed using bacterial 16S-rDNA-pyrosequencing...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28688977/prevalence-of-drug-resistance-among-hiv-1-treatment-naive-patients-in-greece-during-2003-2015-transmitted-drug-resistance-is-due-to-onward-transmissions
#19
D Paraskevis, E Kostaki, G Magiorkinis, P Gargalianos, G Xylomenos, E Magiorkinis, M Lazanas, M Chini, G Nikolopoulos, A Skoutelis, V Papastamopoulos, A Antoniadou, A Papadopoulos, M Psichogiou, G L Daikos, M Oikonomopoulou, A Zavitsanou, G Chrysos, V Paparizos, S Kourkounti, H Sambatakou, N V Sipsas, M Lada, P Panagopoulos, E Maltezos, S Drimis, A Hatzakis
BACKGROUND: The prevalence of HIV-1 drug resistance among treatment-naïve patients ranges between 8.3% and 15% in Europe and North America. Previous studies showed that subtypes A and B were the most prevalent in the Greek HIV-1 epidemic. Our aim was to estimate the prevalence of resistance among drug naïve patients in Greece and to investigate the levels of transmission networking among those carrying resistant strains. METHODS: HIV-1 sequences were determined from 3428 drug naïve HIV-1 patients, in Greece sampled during 01/01/2003-30/6/2015...
July 5, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28679646/multiplexed-elimination-of-wild-type-dna-and-high-resolution-melting-prior-to-targeted-resequencing-of-liquid-biopsies
#20
Ioannis Ladas, Mariana Fitarelli-Kiehl, Chen Song, Viktor A Adalsteinsson, Heather A Parsons, Nancy U Lin, Nikhil Wagle, G Mike Makrigiorgos
BACKGROUND: The use of clinical samples and circulating cell-free DNA (cfDNA) collected from liquid biopsies for diagnostic and prognostic applications in cancer is burgeoning, and improved methods that reduce the influence of excess wild-type (WT) portion of the sample are desirable. Here we present enrichment of mutation-containing sequences using enzymatic degradation of WT DNA. Mutation enrichment is combined with high-resolution melting (HRM) performed in multiplexed closed-tube reactions as a rapid, cost-effective screening tool before targeted resequencing...
July 5, 2017: Clinical Chemistry
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