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https://www.readbyqxmd.com/read/28316757/antigenotoxic-properties-of-agaricus-blazei-against-hydrogen-peroxide-in-human-peripheral-blood-cells
#1
Lada Živković, Sunčica Borozan, Andrea Čabarkapa, Dijana Topalović, Ummi Ciptasari, Vladan Bajić, Biljana Spremo-Potparević
The ability of Agaricus blazei mushroom in its dried and powdered mycelial form was evaluated for its antigenotoxic properties for the first time. Antigenotoxic effects in human peripheral blood cells against H2O2-induced DNA damage were examined in pretreatment and posttreatment protocol by comet assay. The results showed better antigenotoxic properties of Agaricus blazei on the interventional level, respectively, after treatment. Agaricus blazei in concentration of 250 μg/mL after treatment was most efficient in regard to its action against DNA damage...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28274246/decreased-cytokine-production-by-mononuclear-cells-after-severe-gram-negative-infections-early-clinical-signs-and-association-with-final-outcome
#2
Nikolaos Antonakos, Thomas Tsaganos, Volker Oberle, Iraklis Tsangaris, Malvina Lada, Aikaterini Pistiki, Nikolaos Machairas, Maria Souli, Michael Bauer, Evangelos J Giamarellos-Bourboulis
BACKGROUND: Failure of circulating monocytes for adequate cytokine production is a trait of sepsis-induced immunosuppression; however, its duration and association with final outcome are poorly understood. METHODS: We conducted a substudy of a large randomised clinical trial. Peripheral blood mononuclear cells (PBMCs) were isolated within the first 24 h from the onset of systemic inflammatory response syndrome in 95 patients with microbiologically confirmed or clinically suspected gram-negative infections...
March 9, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28260301/-identification-of-hla-class-%C3%A2-susceptible-alleles-and-genotypes-in-latent-autoimmune-diabetes-in-adults
#3
N N Yin, S M Luo, J Lin, Z G Xie, G Huang, X Li, P L Zheng, J P Wang, Z G Zhou
Objective: To identify human leukocyte antigen (HLA)-DRB1, DQA1 and DQB1 susceptible alleles and genotypes in latent autoimmune diabetes in adults (LADA) patients of Chinese Han nationality. Methods: All subjects including 652 LADA patients and 1 181 healthy controls from 1999 to 2015 in Han nationality region of Hunan province were genotyped with high resolution at HLA-DRB1, DQA1 and DQB1 locus by PCR-sequence based typing (PCR-SBT). Frequencies of genotypes between patients and controls were compared by chi square test...
February 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28244653/traditional-and-complementary-medicine-used-with-curative-intent-in-childhood-cancer-a-systematic-review
#4
Caroline Diorio, Kristen Salena, Elena J Ladas, Catherine G Lam, Glenn M Afungcwhi, Festus Njuguna, Stacey Marjerrison
Traditional and complementary medicine (T&CM) strategies are widely utilized in pediatric oncology, with many families reporting T&CM use with the intention to cure cancer. Study of T&CM agents presents many challenges, as a heterogeneous group of agents and techniques are used for a variety of different purpose in many different oncologic conditions. We present a systematic review of the literature examining published reports in which T&CM agents are used with an intention of cure. Twenty-two reports were identified, with most reports being of poor quality...
February 28, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28198081/latent-autoimmune-diabetes-in-adults-lada-in-asian-and-european-populations
#5
REVIEW
Alok Kumar, Alberto de Leiva
Diabetes mellitus is a chronic disorder caused by relative or absolute insulin deficiency and characterized by chronic hyperglycaemia. It is expected that by year 2025, 80% of all type 2 diabetic patients will be living in developing or low- and middle-income countries. Among Asians, there has been an overall increase in abdominal obesity; however, the risk of diabetes in these populations starts at much lower body mass index as compared to Caucasians. A significant proportion of diabetic patients with adult-onset, initially nonrequiring insulin treatment, have diabetes-associated autoantibodies in their sera...
February 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28176457/predictors-of-acupuncture-use-among-children-and-adolescents-with-cancer
#6
Sagar K Chokshi, Elena J Ladas, Katherine Taromina, Douglas McDaniel, Diane Rooney, Zhezhen Jin, Wei-Chun Hsu, Kara M Kelly
BACKGROUND: Evidence for the application of acupuncture in pediatric oncology is limited. We investigated the acceptance of acupuncture and factors associated with its use among children and adolescents with cancer. METHODS: Ninety acupuncture-naïve children receiving cancer treatment at Columbia University Medical Center (CUMC) provided consent/assent for participation. Participants could choose to receive or refuse integrative services offered at CUMC. Symptoms were collected for a 6-month period with the Memorial Symptom Assessment Scale (MSAS)...
February 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28172665/p279-children-born-to-mothers-with-inflammatory-bowel-disease-is-there-any-risk-for-newborns-complication-and-development-during-the-childhood
#7
K Farkas, K Szántό, N Vass, D Szűcs, A Demcsák, S Lada, T Nyári, A Milassin, M Rutka, R Bor, A Bálint, A Fábián, F Nagy, Z Szepes, A Marik, T Molnár
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28148207/clinical-cancer-advances-2017-annual-report-on-progress-against-cancer-from-the-american-society-of-clinical-oncology
#8
Harold J Burstein, Lada Krilov, Jeanny B Aragon-Ching, Nancy N Baxter, E Gabriela Chiorean, Warren Allen Chow, John Frederick De Groot, Steven Michael Devine, Steven G DuBois, Wafik S El-Deiry, Andrew S Epstein, John Heymach, Joshua Adam Jones, Deborah K Mayer, Rebecca A Miksad, Nathan A Pennell, Michael S Sabel, Richard L Schilsky, Lynn Mara Schuchter, Nadine Tung, Karen Marie Winkfield, Lori J Wirth, Don S Dizon
A MESSAGE FROM ASCO'S PRESIDENT I am pleased to present Clinical Cancer Advances 2017, which highlights the most promising advances in patient-oriented cancer research over the past year. The report gives us an opportunity to reflect on what an exciting time it is for cancer research and how swiftly our understanding of cancer has improved. One year ago, the White House announced the national Cancer Moonshot program to accelerate progress against cancer. This shared vision of progress has reinvigorated the research community, identified new areas of scientific collaboration, and raised our ambitions regarding what may be possible beyond the progress we have already made...
February 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28139970/hemodialysis-refractory-metformin-associated-lactate-acidosis-with-hypoglycemia-hypothermia-and-bradycardia-in-a-diabetic-patient-with-belated-diagnosis-and-chronic-kidney-disease%C3%A2
#9
Lada Zibar, Karin Zibar
Metformin is a first-line oral antidiabetic therapy for patients with type 2 diabetes mellitus. Metformin-associated lactate acidosis (MALA) is a well-known, life-threatening, but rare side effect of metformin therapy. Chronic kidney disease (CKD) patients have a much greater risk of MALA. We report the case of a severe refractory MALA despite hemodialysis (HD) treatment, associated with hypoglycemia, hypothermia, and bradycardia in a neglected and thus untimely-recognized CKD patient with type 2 diabetes mellitus...
January 30, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28114807/inverse-relationship-between-type-1-diabetes-mellitus-and-migraine-data-from-the-nord-tr%C3%A3-ndelag-health-surveys-1995-1997-and-2006-2008
#10
Knut Hagen, Bjørn Olav Åsvold, Kristian Midthjell, Lars Jacob Stovner, John-Anker Zwart, Mattias Linde
Aims The aim of this cross-sectional population-based study was to investigate the associations between migraine and type 1 and type 2 diabetes mellitus (DM). Methods We used data from the second (1995-1997) and third survey (2006-2008) in the Nord-Trøndelag Health Study. Analyses were made for the 26,121 participants (30-97 years of age, median 58.3 years) with known headache and DM status in both surveys, and for the 39,584 participants in the third survey (20-97 years, median 54.1 years). The diagnosis of migraine was given to those who fulfilled the questionnaire-based migraine diagnosis in the second and/or third survey...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28088294/suitability-of-small-diagnostic-peripheral-blood-samples-for-cell-therapy-studies
#11
Coralea Stephanou, Panayiota Papasavva, Myria Zachariou, Petros Patsali, Marilena Epitropou, Petros Ladas, Ruba Al-Abdulla, Soteroulla Christou, Michael N Antoniou, Carsten W Lederer, Marina Kleanthous
BACKGROUND AIMS: Primary hematopoietic stem and progenitor cells (HSPCs) are key components of cell-based therapies for blood disorders and are thus the authentic substrate for related research. We propose that ubiquitous small-volume diagnostic samples represent a readily available and as yet untapped resource of primary patient-derived cells for cell- and gene-therapy studies. METHODS: In the present study we compare isolation and storage methods for HSPCs from normal and thalassemic small-volume blood samples, considering genotype, density-gradient versus lysis-based cell isolation and cryostorage media with different serum contents...
February 2017: Cytotherapy
https://www.readbyqxmd.com/read/28065264/a-new-method-to-determine-the-transmembrane-conformation-of-substrates-in-intramembrane-proteolysis-by-deep-uv-resonance-raman-spectroscopy
#12
J W Cooley, A Abdine, M Brown, J Chavez, B Lada, R D JiJi, I Ubarretxena-Belandia
We present a new method based on deep-UV resonance Raman spectroscopy to determine the backbone conformation of intramembrane protease substrates. The classical amide vibrational modes reporting on the conformation of just the transmembrane region of the substrate can be resolved from solvent exchangeable regions outside the detergent micelle by partial deuteration of the solvent. In the presence of isotopically triple-labeled intramembrane protease, these amide modes can be accurately measured to monitor the transmembrane conformation of the substrate during intramembrane proteolysis...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28052296/clinical-and-biochemical-influence-of-prostatic-stones
#13
Tomislav Soric, Mirnes Selimovic, Lada Bakovic, Tatjana Šimurina, Robert Selthofer, Jerka Dumic
INTRODUCTION: The study aimed to explore clinical influence of prostatic stones on lower urinary tract symptoms (LUTS), seminal plasma cytokines, and serum biomarkers. MATERIALS AND METHODS: A total of 70 men aged ≤50 years with LUTS divided into 2 groups: group with stones (GSt) and group without prostatic stones (GNoSt). All subjects completed the International Prostate Symptom Score (IPSS) questionnaire and National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scoring questionnaire...
January 5, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28051281/genetic-variation-in-leptin-and-leptin-receptor-genes-is-a-risk-factor-for-idiopathic-recurrent-spontaneous-abortion
#14
Andrijana Müller, Jasenka Wagner, Alenka Hodžić, Aleš Maver, Ivana Škrlec, Marija Heffer, Lada Zibar, Borut Peterlin
AIM: To determine whether maternal leptin (LEP) and leptin receptor (LEPR) gene polymorphisms are associated with idiopathic recurrent spontaneous abortion (IRSA). METHODS: This case-control association study conducted from 2010 to 2012 at the Department of Gynecology and Obstetrics, University Hospital Center Osijek and Clinical Institute of Medical Genetics Ljubljana included 178 women with a history of three or more IRSAs before the 22nd week of gestation and 145 women with at least two live births and no history of pathologic pregnancies during reproductive period...
December 31, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/28011361/unexpected-effect-of-dry-olive-leaf-extract-on-the-level-of-dna-damage-in-lymphocytes-of-lead-intoxicated-workers-before-and-after-cana2edta-chelation-therapy
#15
Andrea Čabarkapa, Dragana Dekanski, Lada Živković, Mirjana Milanović-Čabarkapa, Vladan Bajić, Dijana Topalović, Francesca Giampieri, Massimiliano Gasparrini, Maurizio Battino, Biljana Spremo-Potparević
The CaNa2EDTA chelation therapy is often practiced with antioxidant supplementation. Dry olive leaf extract (DOLE) is natural product with antioxidant and DNA protective properties. The effects of DOLE on the levels of DNA damage were investigated ex vivo in peripheral blood lymphocytes (PBLs) of 19 workers occupationally exposed to lead (Pb), before and after CaNa2EDTA chelation therapy. DOLE demonstrated pronounced radical scavenging activity in concentrations ≥1 mg/mL, and showed no genotoxicity per se, in concentrations 0...
December 21, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28005367/size-dependent-structure-relations-between-nanotubes-and-encapsulated-nanocrystals
#16
Andrei A Eliseev, Nikolay S Falaleev, Nikolay I Verbitskiy, Andrei A Volykhov, Lada V Yashina, Andrei S Kumskov, Victoria G Zhigalina, Alexander L Vasiliev, Alexey V Lukashin, Jeremy Sloan, Nikolay A Kiselev
The structural organization of compounds in a confined space of nanometer-scale cavities is of fundamental importance for understanding the basic principles for atomic structure design at the nanolevel. Here, we explore size-dependent structure relations between one-dimensional PbTe nanocrystals and carbon nanotube containers in the diameter range of 2.0-1.25 nm using high-resolution transmission electron microscopy and ab initio calculations. Upon decrease of the confining volume, one-dimensional crystals reveal gradual thinning, with the structure being cut from the bulk in either a <110> or a <100> growth direction until a certain limit of ∼1...
January 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/27984548/capillary-nonperfusion-and-photoreceptor-loss-in-branch-retinal-vein-occlusion-spatial-correlation-and-morphologic-characteristics
#17
Menelaos G Kanakis, Konstantina Giannouli, Konstantinos Andreanos, Dimitrios Papaconstantinou, Chrysanthi Koutsandrea, Ioannis Ladas, Ilias Georgalas, Petros Petrou, Athanasios I Kotsolis
PURPOSE: To evaluate the photoreceptor layer in eyes with branch retinal vein occlusion associated with macular ischemia, using a method of en face optical coherence tomography (OCT) representation of the ellipsoid zone. METHODS: Customized macular OCT scans of 9 patients (10 eyes) with branch retinal vein occlusion and macular ischemia were exported and subsequently postprocessed (removal of vascular and cystic spaces' shadows, segmentation, and alignment to the retinal pigment epithelium)...
December 14, 2016: Retina
https://www.readbyqxmd.com/read/27979625/a-method-to-identify-drivers-of-societal-change-likely-to-affect-natural-assets-in-the-future-illustrated-with-australia-s-native-biodiversity
#18
D A Pepper, Hania Lada, James R Thomson, K Shuvo Bakar, P S Lake, Ralph Mac Nally
Human society has a profound adverse effect on natural assets as human populations increase and as global climate changes. We need to envisage different futures that encompass plausible human responses to threats and change, and become more mindful of their likely impacts on natural assets. We describe a method for developing a set of future scenarios for a natural asset at national scale under ongoing human population growth and climate change. The method involves expansive consideration of potential drivers of societal change, a reduction of these to form a small set of key drivers to which contrasting settings are assigned, which we use to develop a set of different scenarios...
December 13, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27934986/a-unique-copper-ii-assisted-transformation-of-acetylacetone-dioxime-in-acetone-that-leads-to-one-dimensional-quinoxaline-bridged-coordination-polymers
#19
Zoi G Lada, Amaia Soto Beobide, Aikaterini Savvidou, Catherine P Raptopoulou, Vassilis Psycharis, George A Voyiatzis, Mark M Turnbull, Spyros P Perlepes
The reactions of copper(ii) carboxylate sources with acetylacetone dioxime (acacdoH2) in Me2CO have been studied and a novel, metal ion-assisted ligand transformation has been discovered. The reaction of [Cu2(diba)4(dibaH)2] and acacdoH2 (1 : 1.5) in Me2CO has provided access to the complex {[Cu2(diba)4(qunx)]}n (1) in low yield (25-30%), where dibaH is 3,3-dimethylbutyric acid and qunx is quinoxaline. The [Cu2(piv)4(pivH)2]/acacdoH2 (1 : 1.5) reaction system in warm Me2CO, where pivH is pivalic acid, gave the analogous complex {[Cu2(piv)4(qunx)]}n (2) in moderate yield (∼50%)...
December 20, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27931088/sglt2-inhibitors-a-systematic-review-of-diabetic-ketoacidosis-and-related-risk-factors-in-the-primary-literature
#20
Kelly R Burke, Christine A Schumacher, Spencer E Harpe
STUDY OBJECTIVE: Currently only minimal information is available regarding risk factors for the development of sodium glucose cotransporter-2 inhibitor (SGLT2i)-related diabetic ketoacidosis (DKA). We aim to identify individual patient characteristics associated with cases of SGLT2i-related DKA to better describe potential risk factors. DESIGN: Systematic review of primary literature. PATIENTS: Thirty-four case reports of patients with type 1 and type 2 diabetes mellitus who developed DKA while receiving an SGLT2i...
February 2017: Pharmacotherapy
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